Detailed information for compound 44665

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 407.914 | Formula: C20H28ClN4O3-
  • H donors: 1 H acceptors: 3 LogP: 3.94 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC(=O)C1CCN(CC1)c1nc(N)c2c(n1)cc(c(c2)OC)OC.[Cl-]
  • InChi: 1S/C20H28N4O3.ClH/c1-4-5-6-16(25)13-7-9-24(10-8-13)20-22-15-12-18(27-3)17(26-2)11-14(15)19(21)23-20;/h11-13H,4-10H2,1-3H3,(H2,21,22,23);1H/p-1
  • InChiKey: BHFFTAOFOBYFPX-UHFFFAOYSA-M  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus beta LACTamase domain containing family member 0.0147 0.0199 0.0478
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0011 0.0026
Schistosoma mansoni ocrl type II inositol 5-phosphatase 0.0016 0.0003 0.0007
Echinococcus multilocularis muscleblind protein 0.0302 0.0432 0.1035
Plasmodium falciparum DEAD/DEAH box helicase, putative 0.0021 0.0011 0.0036
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0035 0.0032 0.0106
Loa Loa (eye worm) hypothetical protein 0.0031 0.0027 0.0298
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0003 0.0011
Onchocerca volvulus 0.0147 0.0199 0.0198
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0037 0.0089
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0022 0.007
Brugia malayi ecdysteroid receptor 0.0021 0.0011 0.0011
Brugia malayi ImpB/MucB/SamB family protein 0.0116 0.0154 0.0207
Echinococcus multilocularis geminin 0.0866 0.1278 0.3063
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0037 0.0089
Brugia malayi jmjC domain containing protein 0.0103 0.0134 0.018
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0024 0.0029
Loa Loa (eye worm) doublecortin family protein 0.002 0.001 0.0112
Loa Loa (eye worm) hypothetical protein 0.0302 0.0432 0.4866
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Brugia malayi Pyruvate kinase, muscle isozyme 0.0033 0.0029 0.0036
Entamoeba histolytica hypothetical protein 0.011 0.0144 0.0925
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0035 0.0032 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0061 0.0214
Loa Loa (eye worm) hypothetical protein 0.004 0.004 0.0449
Echinococcus multilocularis expressed protein 0.0035 0.0032 0.0077
Toxoplasma gondii RNA-directed DNA polymerase 0.1826 0.2717 1
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Trypanosoma brucei hypothetical protein, conserved 0.0147 0.0199 0.0723
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.0096 0.0341
Brugia malayi PHD-finger family protein 0.0019 0.0009 0.0008
Onchocerca volvulus 0.0016 0.0003 0.0002
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0097 0.035
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0362 0.0868
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.0027
Trichomonas vaginalis set domain proteins, putative 0.0248 0.0352 0.4201
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0031 0.0101
Mycobacterium ulcerans hypothetical protein 0.0028 0.0022 0.02
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0029 0.0095
Mycobacterium ulcerans lipase LipD 0.0147 0.0199 0.2342
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0032
Echinococcus multilocularis Chromo domain 0.0023 0.0015 0.0036
Echinococcus multilocularis flap endonuclease 1 0.0078 0.0097 0.0232
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0025 0.0018 0.0053
Echinococcus multilocularis BRK domain containing protein 0.0023 0.0015 0.0036
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0147 0.0199 0.027
Echinococcus multilocularis peregrin 0.0049 0.0054 0.0129
Echinococcus granulosus cpg binding protein 0.0133 0.0179 0.043
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0011 0.0026
Leishmania major DNA polymerase eta, putative 0.0116 0.0154 0.0555
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0155 0.0561
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0016 0.0004 0.0001
Giardia lamblia DNA repair protein RAD52 0.1043 0.1543 0.5675
Leishmania major hypothetical protein, conserved 0.0016 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0032
Brugia malayi Muscleblind-like protein 0.0302 0.0432 0.0591
Loa Loa (eye worm) hypothetical protein 0.0033 0.0029 0.0323
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.0096 0.109
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0046 0.0049 0.0118
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0049 0.0118
Echinococcus granulosus polybromo 1 0.0014 0 0.0001
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0194 0.027 0.3045
Echinococcus multilocularis traf and tnf receptor associated protein 0.0016 0.0003 0.0008
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0005 0.0011
Brugia malayi F/Y-rich N-terminus family protein 0.0044 0.0045 0.0058
Echinococcus granulosus pyruvate kinase 0.0017 0.0005 0.0012
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0018 0.002
Brugia malayi PHD-finger family protein 0.0061 0.0072 0.0094
Giardia lamblia Kinase, PLK 0.0194 0.027 0.0985
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family member 0.0016 0.0004 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Plasmodium vivax pyruvate kinase, putative 0.0033 0.0029 0.0095
Giardia lamblia Pyruvate kinase 0.0033 0.0029 0.0095
Giardia lamblia Telomerase catalytic subunit 0.1826 0.2717 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0194 0.027 0.0985
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.002 0.0047
Brugia malayi follicle stimulating hormone receptor 0.0233 0.0329 0.0448
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0322 0.0463 0.5216
Brugia malayi steroid hormone receptor 0.0021 0.0011 0.0011
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0034 0.008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0121
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.001 0.0025
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0037 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0106
Mycobacterium tuberculosis Conserved protein 0.0147 0.0199 0.1422
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0016 0.0039
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0053 0.0059 0.0207
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0049 0.0551
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0014 0.0082
Echinococcus granulosus RUN 0.002 0.001 0.0025
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0362 0.0868
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0011
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0025 0.008
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0022 0.007
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0096 0.1116
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0155 0.181
Brugia malayi TAR-binding protein 0.0255 0.0362 0.0495
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0144 0.0345
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0016 0.0039
Giardia lamblia Flap structure-specific endonuclease 0.0078 0.0097 0.0345
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0011 0.0026
Entamoeba histolytica hypothetical protein 0.0297 0.0425 0.2744
Loa Loa (eye worm) hypothetical protein 0.0149 0.0203 0.229
Echinococcus multilocularis Protein lozenge 0.0054 0.0061 0.0146
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.1043 0.1543 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0037 0.0125
Toxoplasma gondii DNA methyltransferase 2, putative 0.0021 0.0011 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0005 0.0005
Brugia malayi MH2 domain containing protein 0.0018 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0059
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Loa Loa (eye worm) beta-lactamase 0.0147 0.0199 0.2243
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0037 0.0409
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0011 0.0027
Echinococcus granulosus snurportin 1 0.0322 0.0463 0.111
Brugia malayi mbt repeat family protein 0.0046 0.0049 0.0063
Entamoeba histolytica deoxycytidyl transferase, putative 0.0091 0.0116 0.0744
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0194 0.027 0.0648
Echinococcus multilocularis muscleblind protein 1 0.0302 0.0432 0.1035
Mycobacterium tuberculosis Probable lipase LipD 0.0147 0.0199 0.1422
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0233 0.0329 0.3701
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0155 0.0561
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0041 0.0042 0.01
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0003 0.0011
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0078 0.0097 0.0345
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.0656 0.1573
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0059 0.0656
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0037 0.0089
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1826 0.2717 1
Brugia malayi mbt repeat family protein 0.0046 0.0049 0.0063
Trypanosoma brucei ISWI complex protein 0.0032 0.0028 0.0092
Loa Loa (eye worm) TAR-binding protein 0.0255 0.0362 0.4083
Brugia malayi Pre-SET motif family protein 0.0218 0.0307 0.0419
Plasmodium falciparum phd finger protein, putative 0.0031 0.0027 0.0093
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0021 0.0011 0.0026
Echinococcus granulosus mothers against decapentaplegic 2 0.0018 0.0007 0.0018
Echinococcus granulosus importin subunit beta 1 0.003 0.0025 0.006
Brugia malayi MAP kinase sur-1 0.0053 0.0059 0.0076
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.001 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0022 0.007
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Schistosoma mansoni helicase 0.0141 0.0191 0.0456
Leishmania major importin beta-1 subunit, putative 0.0024 0.0016 0.0049
Schistosoma mansoni Smad4 0.0018 0.0007 0.0017
Schistosoma mansoni loxhd1 0.002 0.001 0.0024
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0011 0.0027
Brugia malayi Smad1 0.0041 0.0042 0.0053
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0029 0.0312
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0059 0.014
Schistosoma mansoni myst-related protein 0.0015 0.0002 0.0003
Plasmodium falciparum flap endonuclease 1 0.0078 0.0097 0.0351
Toxoplasma gondii ABC1 family protein 0.0147 0.0199 0.0723
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0011 0.0011
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0147 0.0199 0.1422
Mycobacterium ulcerans esterase/lipase LipP 0.0147 0.0199 0.2342
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0059 0.0204
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0011 0.0026
Echinococcus granulosus Smad4 0.0041 0.0042 0.01
Brugia malayi Bromodomain containing protein 0.0084 0.0106 0.0142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0121
Schistosoma mansoni pyruvate kinase 0.0017 0.0005 0.0011
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0548
Onchocerca volvulus 0.0021 0.0011 0.001
Schistosoma mansoni hypothetical protein 0.0127 0.017 0.0407
Plasmodium vivax hypothetical protein, conserved 0.0147 0.0199 0.0723
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0005 0.0011
Brugia malayi Importin beta-1 subunit 0.003 0.0025 0.003
Schistosoma mansoni myst-related protein 0.0015 0.0002 0.0003
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0005 0.0005
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0045 0.0108
Toxoplasma gondii hypothetical protein 0.0051 0.0056 0.0195
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.0096 0.5
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0059
Loa Loa (eye worm) CXXC zinc finger family protein 0.0124 0.0166 0.1863
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0031 0.0101
Schistosoma mansoni rotamase 0.0035 0.0032 0.0076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.005 0.012
Echinococcus granulosus muscleblind protein 0.0302 0.0432 0.1035
Onchocerca volvulus 0.0248 0.0352 0.035
Trypanosoma cruzi pantothenate kinase subunit, putative 0.0017 0.0005 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0059 0.0204
Echinococcus granulosus dna polymerase eta 0.0116 0.0154 0.0368
Loa Loa (eye worm) RNA binding protein 0.0255 0.0362 0.4083
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0063 0.0701
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0144 0.0345
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0011 0.0026
Onchocerca volvulus 0.0055 0.0063 0.0061
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0003 0.0011
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0243 0.0242
Trichomonas vaginalis pyruvate kinase, putative 0.0033 0.0029 0.0312
Brugia malayi hypothetical protein 0.002 0.001 0.001
Brugia malayi hypothetical protein 0.0078 0.0097 0.0129
Echinococcus multilocularis zinc finger protein 0.005 0.0055 0.0131
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0096 0.0347
Echinococcus granulosus global transcription activator snf2l2 0.0141 0.0191 0.0457
Onchocerca volvulus 0.002 0.001 0.0009
Echinococcus granulosus exonuclease 1 0.0016 0.0004 0.0009
Loa Loa (eye worm) glutaminase 2 0.0569 0.0833 0.9388
Echinococcus multilocularis DNA repair protein complementing XP G cells 0.0016 0.0004 0.0009
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0046 0.0159
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0103 0.0134 0.0321
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0025 0.0018 0.0104
Loa Loa (eye worm) XPG I-region family protein 0.0016 0.0004 0.0036
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0004 0.0001
Schistosoma mansoni hypothetical protein 0.0035 0.0032 0.0076
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.0454 0.166
Schistosoma mansoni hypothetical protein 0.0031 0.0027 0.0064
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0031 0.0101
Onchocerca volvulus 0.0431 0.0625 0.0624
Giardia lamblia Exonuclease 1 0.0016 0.0004 0.0001
Trypanosoma cruzi polo-like protein kinase, putative 0.0194 0.027 0.0985
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0011 0.0011
Entamoeba histolytica endonuclease/exonuclease/phosphatase domain containing protein 0.0016 0.0003 0.0011
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0127 0.017 0.0407
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0004 0.0001
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0003 0.0032
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0014 0.0081
Echinococcus granulosus tar DNA binding protein 0.0255 0.0362 0.0869
Trichomonas vaginalis DNA helicase recq1, putative 0.0085 0.0106 0.1244
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Schistosoma mansoni neutral sphingomyelinase 0.0016 0.0003 0.0007
Echinococcus multilocularis BRK domain containing protein 0.0023 0.0015 0.0036
Schistosoma mansoni hypothetical protein 0.0023 0.0015 0.0035
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0003 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.0027
Echinococcus multilocularis lamin dm0 0.0055 0.0063 0.015
Schistosoma mansoni exonuclease 0.0016 0.0004 0.0008
Loa Loa (eye worm) helicase DNA-binding protein 0.0023 0.0015 0.0164
Entamoeba histolytica inositol polyphosphate 5-phosphatase, putative 0.0016 0.0003 0.0011
Mycobacterium ulcerans hypothetical protein 0.0147 0.0199 0.2342
Loa Loa (eye worm) Smad1 0.0041 0.0042 0.0465
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0032
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0084 0.0296
Brugia malayi PHD-finger family protein 0.0031 0.0027 0.0032
Onchocerca volvulus Putative neutral sphingomyelinase 0.0016 0.0003 0.0002
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0046 0.0159
Mycobacterium ulcerans hypothetical protein 0.0023 0.0014 0.0106
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0254 0.0609
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0401 0.058 0.0795
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0059 0.0141
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0127 0.017 0.0407
Leishmania major hypothetical protein, conserved 0.0078 0.0097 0.0344
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0032 0.004
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0005 0.0011
Echinococcus multilocularis global transcription activator snf2l2 0.0141 0.0191 0.0457
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0037 0.0047
Schistosoma mansoni synaptojanin 0.0016 0.0003 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.0027
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0005 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0002 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0014 0.0081
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0316 0.0454 0.166
Mycobacterium ulcerans pyruvate kinase 0.0033 0.0029 0.0283
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0037 0.0088
Schistosoma mansoni hypothetical protein 0.0044 0.0045 0.0107
Brugia malayi RNA binding protein 0.0255 0.0362 0.0495
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0006 0.0009
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0059 0.0204
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0112
Echinococcus granulosus CCR4 NOT transcription complex subunit 6 0.0016 0.0003 0.0008
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0036 0.0034 0.0081
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.0096 0.023
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0011
Echinococcus granulosus methyl CpG binding domain protein 2 0.0036 0.0034 0.0081
Loa Loa (eye worm) hypothetical protein 0.0099 0.0128 0.1435
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0059 0.014
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Echinococcus multilocularis musashi 0.0055 0.0063 0.015
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0011
Echinococcus multilocularis microtubule associated protein 2 0.2797 0.4171 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0201
Leishmania major DNA damage repair protein, putative 0.0028 0.0022 0.007
Schistosoma mansoni carbon catabolite repressor protein 0.0016 0.0003 0.0007
Loa Loa (eye worm) hypothetical protein 0.007 0.0085 0.0949
Schistosoma mansoni methyl-cpg binding protein mbd 0.0036 0.0034 0.008
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0011 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0031 0.0073
Loa Loa (eye worm) flap endonuclease-1 0.0078 0.0097 0.1088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Loa Loa (eye worm) latrophilin receptor protein 2 0.0127 0.017 0.1911
Brugia malayi MH1 domain containing protein 0.0041 0.0042 0.0053
Echinococcus multilocularis bloom syndrome protein 0.0085 0.0106 0.0255
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0191 0.0266 0.0636
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0121
Loa Loa (eye worm) hypothetical protein 0.0078 0.0097 0.1085
Trypanosoma brucei protein kinase, putative 0.0053 0.0059 0.0204
Loa Loa (eye worm) hypothetical protein 0.0127 0.017 0.1911
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0059 0.0141
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0362 0.0868
Brugia malayi hypothetical protein 0.005 0.0055 0.0072
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0016 0.0049
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0401 0.058 0.6541
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0199 0.0723
Leishmania major T-complex protein 1, beta subunit, putative 0.0025 0.0018 0.0053
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.0096 0.1075
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0024
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0037 0.0125
Echinococcus multilocularis deoxyribonuclease 1 2 0.0016 0.0003 0.0008
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0127 0.017 0.0407
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0005 0.0002
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0032 0.0075
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0005 0.0005
Plasmodium falciparum endonuclease/exonuclease/phosphatase family protein, putative 0.0016 0.0003 0.0006
Plasmodium falciparum DNA repair protein REV1, putative 0.0028 0.0022 0.0076
Echinococcus granulosus neutral sphingomyelinase 0.0016 0.0003 0.0008
Plasmodium falciparum T-complex protein 1 subunit beta 0.0025 0.0018 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0011
Echinococcus granulosus inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0003 0.0008
Echinococcus granulosus TGF beta signal transducer SmadC 0.0041 0.0042 0.01
Echinococcus multilocularis cpg binding protein 0.0133 0.0179 0.043
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0011
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0078 0.0097 0.0345
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0003 0.0032
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0011 0.006
Brugia malayi N-terminal motif family protein 0.0176 0.0243 0.033
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0063 0.0082
Schistosoma mansoni hypothetical protein 0.1266 0.1877 0.45
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0003 0.0011
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0004 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0011
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0254 0.0609
Echinococcus multilocularis tar DNA binding protein 0.0255 0.0362 0.0869
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0011 0.0011
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.0027
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0059 0.0204
Leishmania major pyruvate kinase 0.0033 0.0029 0.0095
Loa Loa (eye worm) MH2 domain-containing protein 0.0041 0.0042 0.0465
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.005 0.0563
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0003 0.0011
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0052 0.0124
Brugia malayi nuclear hormone receptor 0.0021 0.0011 0.0011
Schistosoma mansoni bromodomain containing protein 0.0142 0.0193 0.0462
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0053 0.006 0.0208
Plasmodium falciparum ataxin-2 like protein, putative 0.0078 0.0097 0.035
Echinococcus granulosus fetal alzheimer antigen falz 0.0053 0.0059 0.0141
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0061 0.0213
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0049 0.0169
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Schistosoma mansoni terminal deoxycytidyl transferase 0.0091 0.0116 0.0278
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0063 0.0701
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0016 0.0039
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0199 0.2364
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0605 0.0887 1
Trichomonas vaginalis DNA helicase recq, putative 0.0054 0.0061 0.0696
Echinococcus multilocularis exonuclease 1 0.0016 0.0004 0.0009
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0059 0.0204
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0316 0.0454 0.166
Echinococcus multilocularis pyruvate kinase 0.0033 0.0029 0.007
Echinococcus multilocularis CCR4 NOT transcription complex subunit 6 0.0016 0.0003 0.0008
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.0307 0.3459
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0059
Onchocerca volvulus 0.0124 0.0166 0.0164
Loa Loa (eye worm) hypothetical protein 0.0053 0.0059 0.066
Trichomonas vaginalis rotamase, putative 0.0034 0.0031 0.0332
Echinococcus multilocularis BRK domain containing protein 0.0023 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Echinococcus multilocularis pyruvate kinase 0.0017 0.0005 0.0012
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0199 0.2364
Trichomonas vaginalis chaperonin, putative 0.0025 0.0018 0.0174
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0014 0.0106
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0016 0.0003 0.0006
Schistosoma mansoni zinc finger protein 0.0032 0.0028 0.0067
Leishmania major DNA polymerase eta, putative 0.0053 0.006 0.0208
Schistosoma mansoni xp-G/rad2 DNA repair endonuclease family 0.0016 0.0004 0.0008
Entamoeba histolytica hypothetical protein 0.0024 0.0016 0.0097
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0049 0.0118
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Brugia malayi MH2 domain containing protein 0.0605 0.0887 0.1218
Echinococcus multilocularis dnaJ subfamily B 0.1266 0.1877 0.45
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0011 0.0026
Schistosoma mansoni phd finger protein 0.0018 0.0007 0.0015
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Brugia malayi Bromodomain containing protein 0.0167 0.023 0.0312
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0183 0.0254 0.0609
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0135 0.0182 0.0435
Echinococcus granulosus bloom syndrome protein 0.0085 0.0106 0.0255
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0025 0.0018 0.0053
Loa Loa (eye worm) hypothetical protein 0.0431 0.0625 0.7047
Schistosoma mansoni ap endonuclease 0.0077 0.0096 0.0229
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0046 0.0049 0.0548
Schistosoma mansoni hypothetical protein 0.0866 0.1278 0.3063
Leishmania major hypothetical protein, conserved 0.0147 0.0199 0.0723
Leishmania major DNA polymerase kappa, putative 0.0098 0.0126 0.0452
Schistosoma mansoni zinc finger protein 0.005 0.0055 0.013
Loa Loa (eye worm) CCR4-NOT transcription complex subunit 6 family protein 0.0016 0.0003 0.0032
Echinococcus granulosus pyruvate kinase 0.0033 0.0029 0.007
Plasmodium falciparum telomerase reverse transcriptase 0.1826 0.2717 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0031 0.0101
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0014 0.0041
Entamoeba histolytica recQ family helicase, putative 0.0023 0.0014 0.0079
Schistosoma mansoni ap endonuclease 0.0077 0.0096 0.0229
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0015 0.0044
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0198 0.0277 0.0664
Loa Loa (eye worm) hypothetical protein 0.0027 0.002 0.0218
Brugia malayi Disco-interacting protein 2 homolog 0.004 0.004 0.0051
Toxoplasma gondii exonuclease III APE 0.0077 0.0096 0.0341
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.0096 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0046 0.0049 0.0118
Schistosoma mansoni hypothetical protein 0.0298 0.0426 0.102
Schistosoma mansoni cpg binding protein 0.0133 0.0179 0.0429
Mycobacterium ulcerans beta-lactamase 0.0147 0.0199 0.2342
Echinococcus granulosus expressed protein 0.0035 0.0032 0.0077
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0046 0.0049 0.0175
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0147 0.0199 0.2243
Brugia malayi MH2 domain containing protein 0.0041 0.0042 0.0053
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0021 0.0011 0.0028
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.0096 0.0341
Brugia malayi Pyruvate kinase, M2 isozyme 0.0033 0.0029 0.0036
Brugia malayi hypothetical protein 0.0431 0.0625 0.0857
Toxoplasma gondii hypothetical protein 0.0089 0.0113 0.0403
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0022 0.007
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0005 0.0047
Echinococcus granulosus DNA methyltransferase 2, putative 0.0021 0.0011 0.0026
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0098 0.0126 0.0452
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0005 0.0005
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0198 0.0277 0.0664
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.0027
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0049 0.0063
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0059 0.0204
Mycobacterium ulcerans glutaminase 0.0569 0.0833 1
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0005 0.0007
Brugia malayi hypothetical protein 0.011 0.0144 0.0194
Brugia malayi isocitrate dehydrogenase 0.0017 0.0005 0.0002
Brugia malayi T-complex protein 1, beta subunit 0.0025 0.0018 0.002
Loa Loa (eye worm) hypothetical protein 0.0018 0.0006 0.0066
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0059 0.0668
Echinococcus multilocularis neutral sphingomyelinase 0.0016 0.0003 0.0008
Trypanosoma brucei DNA repair protein RAD2, putative 0.0016 0.0004 0.0001
Schistosoma mansoni cpg binding protein 0.0124 0.0166 0.0396
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0045 0.0108
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0162 0.0222 0.2499
Brugia malayi glutaminase DH11.1 0.0569 0.0833 0.1143
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0157
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0005 0.0013
Echinococcus granulosus BRK domain containing protein 0.0023 0.0015 0.0036
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0059 0.0204
Mycobacterium tuberculosis Probable lipase LipE 0.0147 0.0199 0.1422
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0011 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Brugia malayi mothers against decapentaplegic homolog 3 0.0018 0.0007 0.0006
Brugia malayi CXXC zinc finger family protein 0.0124 0.0166 0.0224
Entamoeba histolytica sphingomyelinase C precursor, putative 0.0016 0.0003 0.0011
Schistosoma mansoni rab6-interacting 0.002 0.001 0.0024
Plasmodium falciparum exodeoxyribonuclease III, putative 0.0016 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0147 0.0199 0.2243
Brugia malayi hypothetical protein 0.002 0.001 0.001
Trichomonas vaginalis exonuclease%2C+putative 0.0016 0.0004 0.0005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0037 0.0125
Loa Loa (eye worm) hypothetical protein 0.0054 0.006 0.0676
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.0065 0.0157
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0103 0.0134 0.0321
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0004 0.0001
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0046 0.0159
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0041 0.0042 0.0099
Loa Loa (eye worm) histone methyltransferase 0.003 0.0024 0.027
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0061 0.0213
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0003 0.0032
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0021 0.0011 0.0028
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.003 0.0024 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0015
Leishmania major mitochondrial DNA polymerase beta 0.0316 0.0454 0.166
Schistosoma mansoni hypothetical protein 0.0127 0.017 0.0407
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0022 0.007
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Loa Loa (eye worm) hypothetical protein 0.0176 0.0243 0.2734
Schistosoma mansoni lipoxygenase 0.002 0.001 0.0024
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.0027
Loa Loa (eye worm) hypothetical protein 0.0302 0.0432 0.4866
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0019 0.0009 0.0021
Echinococcus granulosus pyruvate kinase 0.0017 0.0005 0.0012
Echinococcus granulosus flap endonuclease 1 0.0078 0.0097 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0059 0.0668
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.001 0.0026
Leishmania major DNA polymerase kappa, putative 0.0028 0.0022 0.007
Loa Loa (eye worm) hypothetical protein 0.0046 0.0049 0.0551
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.005 0.0121
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0194 0.027 0.0985
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0004 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0362 0.0868
Echinococcus multilocularis BRK domain containing protein 0.0023 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0019 0.0009 0.0095
Loa Loa (eye worm) glutaminase 0.0569 0.0833 0.9388
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Brugia malayi MH1 domain containing protein 0.0023 0.0014 0.0015
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0121
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0147 0.0199 0.1422
Leishmania major telomerase reverse transcriptase, putative 0.1826 0.2717 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0116 0.0154 0.0555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0085 0.0202
Schistosoma mansoni DNA polymerase IV / kappa 0.0028 0.0022 0.0052
Plasmodium vivax ataxin-2 like protein, putative 0.0078 0.0097 0.0344
Schistosoma mansoni polycystin 1-related 0.002 0.001 0.0024
Toxoplasma gondii histone lysine methyltransferase SET1 0.0179 0.0248 0.0903
Schistosoma mansoni importin beta-1 0.003 0.0025 0.0059
Echinococcus multilocularis mothers against decapentaplegic 2 0.0018 0.0007 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.0027
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0018 0.0042
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0059 0.0204
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0297 0.0425 0.2744
Brugia malayi beta-lactamase family protein 0.0147 0.0199 0.027
Trypanosoma brucei unspecified product 0.0111 0.0146 0.0525
Trypanosoma brucei unspecified product 0.0063 0.0074 0.026
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0024 0.0058
Echinococcus multilocularis beta LACTamase domain containing family member 0.0147 0.0199 0.0478
Schistosoma mansoni flap endonuclease-1 0.0071 0.0086 0.0205
Brugia malayi Latrophilin receptor protein 2 0.0127 0.017 0.023
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0155 0.181
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0014 0.0106
Brugia malayi BRM protein 0.0141 0.0191 0.0258
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0059 0.0668
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0011
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0035 0.0032 0.0077
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.1826 0.2717 1
Trypanosoma cruzi ISWI complex protein 0.0032 0.0028 0.0092
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0011
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0201
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0021 0.0011 0.0034
Echinococcus granulosus flap endonuclease GEN 1 0.0016 0.0004 0.0009
Loa Loa (eye worm) BRM protein 0.0075 0.0092 0.1037
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0077 0.0095 0.0343
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0059
Loa Loa (eye worm) hypothetical protein 0.0147 0.0199 0.2243
Onchocerca volvulus Alhambra homolog 0.0031 0.0027 0.0025
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0014 0.0155
Entamoeba histolytica hypothetical protein 0.011 0.0144 0.0925
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0059 0.014
Echinococcus multilocularis snurportin 1 0.0322 0.0463 0.111
Loa Loa (eye worm) hypothetical protein 0.0054 0.0061 0.0686
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0046 0.0049 0.0118
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0153
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0014 0.0041
Schistosoma mansoni synaptojanin 0.0016 0.0003 0.0007
Schistosoma mansoni Smad4 0.0018 0.0007 0.0017
Schistosoma mansoni hypothetical protein 0.0274 0.039 0.0935
Onchocerca volvulus 0.004 0.004 0.0039
Trypanosoma brucei DNA polymerase IV, putative 0.0111 0.0146 0.0525
Schistosoma mansoni lozenge 0.0054 0.0061 0.0145
Giardia lamblia DINP protein human, muc B family 0.0098 0.0126 0.0452
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0003 0.0032
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0024 0.0058
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0025 0.008
Plasmodium vivax importin-beta 2, putative 0.003 0.0025 0.008
Giardia lamblia DNA damage repair protein 0.0028 0.0022 0.007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.0096 0.0341
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0255 0.0362 0.4083
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.006 0.0208
Trypanosoma brucei telomerase reverse transcriptase 0.1826 0.2717 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0097 0.0344
Loa Loa (eye worm) hypothetical protein 0.0055 0.0063 0.0701
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0059 0.0141
Leishmania major pyruvate kinase 0.0033 0.0029 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0011
Trichomonas vaginalis glutaminase, putative 0.0569 0.0833 1
Trypanosoma cruzi DNA damage repair protein, putative 0.0028 0.0022 0.007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0199 0.0477
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0049 0.0118
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0093 0.0224
Schistosoma mansoni pyruvate kinase 0.0033 0.0029 0.0069
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0024 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Echinococcus multilocularis pyruvate kinase 0.0017 0.0005 0.0012
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0147 0.0199 0.2342
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0078 0.0097 0.0345
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0049 0.0048
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0011
Echinococcus multilocularis pyruvate kinase 0.0017 0.0005 0.0012
Brugia malayi Pre-SET motif family protein 0.0034 0.0031 0.0038
Echinococcus granulosus geminin 0.0866 0.1278 0.3063
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0124 0.1456
Onchocerca volvulus 0.0147 0.0199 0.0198
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0021 0.0011 0.0028
Entamoeba histolytica inositol polyphosphate-5-phosphatase, putative 0.0016 0.0003 0.0011
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0006 0.0017
Schistosoma mansoni jumonji domain containing protein 0.0082 0.0102 0.0244
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0183 0.0254 0.0346
Loa Loa (eye worm) hypothetical protein 0.0038 0.0037 0.0414
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0078 0.0097 0.0345
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0049 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Entamoeba histolytica recQ family helicase, putative 0.0054 0.0061 0.0385
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0254 0.0609
Loa Loa (eye worm) hypothetical protein 0.0054 0.0061 0.0684
Onchocerca volvulus 0.0147 0.0199 0.0198
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0004 0.0001
Loa Loa (eye worm) hypothetical protein 0.0116 0.0154 0.1729
Echinococcus multilocularis flap endonuclease GEN 1 0.0016 0.0004 0.0009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Trichomonas vaginalis penicillin-binding protein, putative 0.0147 0.0199 0.2364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0031 0.0073
Echinococcus multilocularis Smad4 0.0041 0.0042 0.01
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0183 0.0254 0.2861
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0016 0.016
Plasmodium vivax DNA repair protein RAD2, putative 0.0016 0.0004 0.0001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0014 0.0083
Echinococcus granulosus mothers against decapentaplegic 5 0.0041 0.0042 0.01
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0098 0.0126 0.089
Trypanosoma cruzi PAB1-binding protein , putative 0.0078 0.0097 0.0344
Echinococcus granulosus pyruvate kinase 0.0033 0.0029 0.007
Echinococcus multilocularis dna polymerase eta 0.0116 0.0154 0.0368
Schistosoma mansoni blooms syndrome DNA helicase 0.0061 0.0071 0.017
Trypanosoma cruzi DNA repair protein RAD2, putative 0.0016 0.0004 0.0001
Schistosoma mansoni smad1 5 8 and 0.0041 0.0042 0.0099
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0006 0.0015
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0011 0.0026
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.0656 0.1573
Brugia malayi RNA, U transporter 1 0.0086 0.0108 0.0145
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0037 0.0088
Brugia malayi Telomerase reverse transcriptase 0.486 0.7263 1
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0005 0.0007
Loa Loa (eye worm) PHD-finger family protein 0.0031 0.0027 0.0298
Echinococcus granulosus dna polymerase kappa 0.0117 0.0155 0.0372
Echinococcus multilocularis polybromo 1 0.0014 0 0.0001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0011
Brugia malayi Flap endonuclease-1 0.0078 0.0097 0.0129
Schistosoma mansoni hypothetical protein 0.0032 0.0028 0.0067
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.007 0.0085 0.0203
Schistosoma mansoni microtubule-associated protein tau 0.2797 0.4171 1
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0038 0.0037 0.0231
Plasmodium falciparum pyruvate kinase 0.0033 0.0029 0.0101
Schistosoma mansoni hypothetical protein 0.011 0.0144 0.0345
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.002 0.0047
Brugia malayi SET domain containing protein 0.0018 0.0007 0.0005
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0014 0.0041
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0015 0.0044
Loa Loa (eye worm) hypothetical protein 0.0048 0.0052 0.058
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0005 0.001
Mycobacterium tuberculosis Conserved protein 0.0147 0.0199 0.1422
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0059 0.014
Loa Loa (eye worm) MH1 domain-containing protein 0.0041 0.0042 0.0465
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0018 0.0042
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0147 0.0199 0.0477
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0007 0.0079
Entamoeba histolytica hypothetical protein 0.011 0.0144 0.0925
Echinococcus multilocularis RUN 0.002 0.001 0.0025
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0084 0.0296
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0124 0.1456
Echinococcus multilocularis BRK domain containing protein 0.0023 0.0015 0.0036
Brugia malayi beta-lactamase 0.0147 0.0199 0.027
Echinococcus multilocularis pyruvate kinase 0.0033 0.0029 0.007
Mycobacterium leprae Probable lipase LipE 0.0147 0.0199 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0016 0.016
Echinococcus multilocularis pyruvate kinase 0.0026 0.0019 0.0045
Schistosoma mansoni hypothetical protein 0.0866 0.1278 0.3063
Brugia malayi Doublecortin family protein 0.002 0.001 0.001
Brugia malayi MH1 domain containing protein 0.0023 0.0014 0.0015
Echinococcus granulosus PHD finger protein rhinoceros 0.0031 0.0027 0.0064
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0004 0.0005
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0037 0.0089
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0204 0.074
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0025 0.0018 0.0174
Trichomonas vaginalis helicase, putative 0.002 0.001 0.0082
Plasmodium falciparum DNA repair protein RAD2, putative 0.0016 0.0004 0.0008
Schistosoma mansoni glutaminase 0.0569 0.0833 0.1996
Loa Loa (eye worm) jmjC domain-containing protein 0.0065 0.0077 0.0862
Echinococcus granulosus smad 0.0041 0.0042 0.01
Plasmodium falciparum LCCL domain-containing protein 0.002 0.001 0.0032
Trypanosoma brucei exonuclease, putative 0.0016 0.0004 0.0001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0121
Trichomonas vaginalis DNA polymerase eta, putative 0.0117 0.0155 0.1834
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0003 0.0006
Echinococcus granulosus pyruvate kinase 0.0017 0.0005 0.0012
Brugia malayi MH1 domain containing protein 0.0041 0.0042 0.0053
Trypanosoma brucei pyruvate kinase 1 0.0033 0.0029 0.0095
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0053 0.0059 0.014
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0011 0.0027
Mycobacterium ulcerans hypothetical protein 0.0167 0.0229 0.2706
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0011 0.0121
Trichomonas vaginalis DNA helicase recq, putative 0.0085 0.0106 0.1244
Echinococcus granulosus synaptojanin 1 0.0016 0.0003 0.0008
Entamoeba histolytica DNA-repair protein, putative 0.0016 0.0004 0.0013
Plasmodium vivax SET domain protein, putative 0.0034 0.0031 0.0101
Echinococcus granulosus intermediate filament protein 0.0055 0.0063 0.015
Loa Loa (eye worm) hypothetical protein 0.009 0.0114 0.1281
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Onchocerca volvulus 0.0034 0.0031 0.0029
Plasmodium vivax DEAD/DEAH helicase, putative 0.0021 0.0011 0.003
Brugia malayi RNA recognition motif domain containing protein 0.0255 0.0362 0.0495
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0037 0.0089
Entamoeba histolytica Flap nuclease, putative 0.0078 0.0097 0.0619
Schistosoma mansoni intermediate filament proteins 0.0055 0.0063 0.0149
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0127 0.017 0.023
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0091 0.0116 0.0278
Loa Loa (eye worm) hypothetical protein 0.0431 0.0625 0.7047
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0014 0.0083
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Brugia malayi latrophilin 2 splice variant baaae 0.0274 0.039 0.0533
Schistosoma mansoni tar DNA-binding protein 0.0255 0.0362 0.0868
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Echinococcus multilocularis importin subunit beta 1 0.003 0.0025 0.006
Loa Loa (eye worm) hypothetical protein 0.0401 0.058 0.6541
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0016 0.016
Echinococcus multilocularis chromodomain helicase DNA binding protein 7 0.0023 0.0015 0.0036
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0147 0.0199 0.2243
Schistosoma mansoni serine/threonine protein kinase 0.0194 0.027 0.0648
Loa Loa (eye worm) T-complex protein 1 0.0025 0.0018 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0117 0.0155 0.1834
Echinococcus granulosus DNA repair protein complementing XP G cells 0.0016 0.0004 0.0009
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0029 0.0323
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0089 0.0113 0.0409
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0023 0.0014 0.0039
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0054 0.0061 0.0212
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0091 0.0116 0.1306
Entamoeba histolytica exonuclease, putative 0.0016 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0036
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0015 0.0016
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0004 0.0005
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.015 0.0204 0.074
Mycobacterium tuberculosis Conserved protein 0.0147 0.0199 0.1422
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0059 0.014
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0024 0.0015 0.0044
Echinococcus granulosus neuropeptide s receptor 0.0451 0.0656 0.1573
Echinococcus granulosus dnaJ subfamily B 0.1266 0.1877 0.45
Schistosoma mansoni smad1 5 8 and 0.0041 0.0042 0.0099
Giardia lamblia PHD finger protein 15 0.0031 0.0027 0.0087
Loa Loa (eye worm) hypothetical protein 0.0017 0.0006 0.0059
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.001 0.0025
Trichomonas vaginalis flap endonuclease-1, putative 0.0016 0.0004 0.0005
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0037 0.0409
Onchocerca volvulus Serine\/threonine kinase homolog 0.0194 0.027 0.0269
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0049 0.0118
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0005 0.0011
Echinococcus multilocularis BRK domain 0.0023 0.0015 0.0036
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0014 0.0083
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0027 0.0087
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0037 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0037 0.0409
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0011 0.0027
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.0656 0.1573
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0049 0.0118
Trichomonas vaginalis lymphoid specific helicase, putative 0.003 0.0024 0.0254
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.007 0.0085 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0022 0.007
Trichomonas vaginalis esterase, putative 0.0147 0.0199 0.2364
Brugia malayi jmjC domain containing protein 0.0047 0.005 0.0065
Leishmania major pantothenate kinase subunit, putative 0.0017 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0033 0.0029 0.0068
Echinococcus granulosus mothers against decapentaplegic 6 0.0018 0.0007 0.0018
Trypanosoma brucei unspecified product 0.0063 0.0074 0.026
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0035 0.0033 0.0078
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0005 0.0005
Echinococcus granulosus zinc finger protein 0.005 0.0055 0.0131
Brugia malayi intermediate filament protein 0.0055 0.0063 0.0082
Plasmodium falciparum importin beta, putative 0.003 0.0025 0.0087
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0059 0.0141
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0036
Toxoplasma gondii LsmAD domain-containing protein 0.0078 0.0097 0.0344
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0025 0.0018 0.0053
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0007
Schistosoma mansoni hypothetical protein 0.0322 0.0463 0.1109
Loa Loa (eye worm) RecQ helicase 0.0085 0.0106 0.1196
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0011 0.0026
Trypanosoma brucei DNA polymerase kappa, putative 0.0098 0.0126 0.0452
Plasmodium falciparum DNase I-like protein, putative 0.0016 0.0003 0.0006
Brugia malayi MH2 domain containing protein 0.0041 0.0042 0.0053
Echinococcus multilocularis mothers against decapentaplegic 6 0.0018 0.0007 0.0018
Echinococcus granulosus traf and tnf receptor associated protein 0.0016 0.0003 0.0008
Echinococcus granulosus Chromo domain 0.0023 0.0015 0.0036
Trypanosoma brucei chrX additional, unordered contigs 0.0028 0.0022 0.007
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0019 0.0009 0.0021
Toxoplasma gondii XPG N-terminal domain-containing protein 0.0016 0.0004 0.0001
Onchocerca volvulus 0.002 0.001 0.0009
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0254 0.0609
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0014 0.0106
Toxoplasma gondii pyruvate kinase PyK1 0.0033 0.0029 0.0095
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0011 0.0121
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0014 0.0106
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0025 0.0018 0.0042
Echinococcus multilocularis GPCR, family 2 0.0127 0.017 0.0407
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0011 0.0027
Loa Loa (eye worm) MBCTL1 0.0053 0.0059 0.066
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0003 0.0011
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0049 0.0118
Schistosoma mansoni kinase 0.0099 0.0128 0.0306
Brugia malayi polk-prov protein 0.0054 0.0061 0.008
Brugia malayi ImpB/MucB/SamB family protein 0.0091 0.0116 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0011
Treponema pallidum ATP-dependent DNA helicase 0.0024 0.0015 0.1283
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.0096 0.0341
Mycobacterium tuberculosis Conserved hypothetical protein 0.0091 0.0116 0.082
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0135 0.0182 0.0435
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0007 0.0079
Schistosoma mansoni SET domain protein 0.0035 0.0033 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0061 0.0214
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0059 0.0668
Loa Loa (eye worm) bromodomain containing protein 0.0041 0.0041 0.0458
Brugia malayi nuclear receptor NHR-88 0.0021 0.0011 0.0011
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0091 0.0116 0.0279
Echinococcus granulosus GPCR family 2 0.0127 0.017 0.0407
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.005 0.012
Plasmodium falciparum carbon catabolite repressor protein 4, putative 0.0016 0.0003 0.0006
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.0096 0.0611
Mycobacterium tuberculosis Probable hydrolase 0.0147 0.0199 0.1422
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0199 0.2364
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0035 0.0033 0.0078
Entamoeba histolytica exonuclease, putative 0.0016 0.0004 0.0013
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.001 0.0025
Loa Loa (eye worm) hypothetical protein 0.0147 0.0199 0.2243
Trypanosoma cruzi hypothetical protein, conserved 0.0147 0.0199 0.0723
Loa Loa (eye worm) nuclear factor I 0.0023 0.0014 0.0153
Leishmania major modification methylase-like protein 0.0021 0.0011 0.0028
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0046 0.0159
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0147 0.0199 0.1422
Echinococcus multilocularis dna polymerase kappa 0.0117 0.0155 0.0372
Onchocerca volvulus 0.0046 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0157
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.001 0.0025
Loa Loa (eye worm) PHD-finger family protein 0.0044 0.0045 0.0504
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.0096 0.0341
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.0096 0.1116
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.1238 0.2967
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.0065 0.0157
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Plasmodium vivax exonuclease I, putative 0.0016 0.0004 0.0001
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0011 0.001
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0155 0.0561
Loa Loa (eye worm) BRM protein 0.0087 0.011 0.1231
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.015 0.0204 0.074
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0144 0.0345
Plasmodium vivax telomerase reverse transcriptase, putative 0.1826 0.2717 1
Trypanosoma brucei polo-like protein kinase 0.0194 0.027 0.0985
Schistosoma mansoni DNA helicase recq1 0.0046 0.0049 0.0117
Giardia lamblia Pyruvate kinase 0.0017 0.0005 0.0007
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0183 0.0254 0.0609
Loa Loa (eye worm) hypothetical protein 0.003 0.0025 0.0278
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.001 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0401 0.058 0.0795
Onchocerca volvulus 0.0023 0.0014 0.0013
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0029 0.0323
Loa Loa (eye worm) hypothetical protein 0.002 0.001 0.0112
Trypanosoma brucei DNA polymerase kappa, putative 0.0069 0.0084 0.0296
Onchocerca volvulus 0.0055 0.0063 0.0061
Echinococcus multilocularis lamin 0.0055 0.0063 0.015
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0029 0.0028
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0031 0.0189
Brugia malayi XPG I-region family protein 0.0016 0.0004 0.0001
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0053 0.0059 0.0141
Loa Loa (eye worm) hypothetical protein 0.0274 0.039 0.4398
Trypanosoma brucei pyruvate kinase 1, putative 0.0033 0.0029 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0015 0.0166
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0011 0.001
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0106
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0059 0.0204
Trichomonas vaginalis rotamase, putative 0.0035 0.0032 0.0347
Loa Loa (eye worm) runx1 0.0054 0.0061 0.0681
Brugia malayi beta-lactamase family protein 0.0147 0.0199 0.027
Schistosoma mansoni hypothetical protein 0.0127 0.017 0.0407
Loa Loa (eye worm) hypothetical protein 0.0081 0.0101 0.1136
Mycobacterium leprae conserved hypothetical protein 0.0147 0.0199 1
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0025 0.008
Trypanosoma brucei DNA polymerase eta, putative 0.0116 0.0154 0.0555
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0024 0.0268
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0031 0.0101
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0018 0.0007 0.0006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0011 0.0027
Giardia lamblia TCP-1 chaperonin subunit beta 0.0025 0.0018 0.0053
Schistosoma mansoni coup transcription factor 0.0021 0.0011 0.0026
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0046 0.0049 0.0118
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0004 0.0007
Echinococcus granulosus lamin 0.0055 0.0063 0.015
Trypanosoma brucei DNA damage repair protein, putative 0.0028 0.0022 0.007
Chlamydia trachomatis pyruvate kinase 0.0033 0.0029 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0078 0.0097 0.1129
Onchocerca volvulus 0.0016 0.0003 0.0002
Loa Loa (eye worm) transcription factor SMAD2 0.0605 0.0887 1
Echinococcus granulosus tumor protein p63 0.0328 0.0472 0.1131
Entamoeba histolytica serine/threonine protein kinase, putative 0.0194 0.027 0.1744
Echinococcus multilocularis inositol polyphosphate 5 phosphatase OCRL 1 0.0016 0.0003 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0011 0.0027
Toxoplasma gondii t-complex protein beta subunit 0.0025 0.0018 0.0053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.0027
Giardia lamblia hypothetical protein 0.0016 0.0004 0.0001
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0194 0.027 0.0648
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0059 0.0077
Echinococcus granulosus microtubule associated protein 2 0.2797 0.4171 1
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.001 0.0025
Schistosoma mansoni rab6-interacting 0.002 0.001 0.0024
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0049 0.0169
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0021 0.0011 0.0025
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0121
Trichomonas vaginalis conserved hypothetical protein 0.002 0.001 0.0082
Echinococcus multilocularis BRK domain containing protein 0.0023 0.0015 0.0036
Echinococcus granulosus peregrin 0.0049 0.0054 0.0129
Trichomonas vaginalis D-aminoacylase, putative 0.0147 0.0199 0.2364
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0025 0.0018 0.0042
Mycobacterium tuberculosis Conserved hypothetical protein 0.0167 0.0229 0.164
Echinococcus multilocularis tumor protein p63 0.0328 0.0472 0.1131
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0037 0.0125
Echinococcus multilocularis smad 0.0041 0.0042 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0032 0.0347
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0093 0.0224
Brugia malayi Bloom's syndrome protein homolog 0.0085 0.0106 0.0142
Brugia malayi serine/threonine-protein kinase plk-2 0.0194 0.027 0.0368
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0011 0.0026
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0041 0.0042 0.0099
Schistosoma mansoni cpg binding protein 0.0133 0.0179 0.0429
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0011 0.0026
Trypanosoma cruzi ISWI complex protein 0.0032 0.0028 0.0092
Toxoplasma gondii PHD-finger domain-containing protein 0.0031 0.0027 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0014 0.0106
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0147 0.0199 0.2243
Entamoeba histolytica endonuclease/exonuclease/phosphatase family protein 0.0016 0.0003 0.0011
Echinococcus granulosus lamin dm0 0.0055 0.0063 0.015
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0011
Schistosoma mansoni blooms syndrome DNA helicase 0.0024 0.0015 0.0035
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0183 0.0254 0.0609
Schistosoma mansoni SET domain protein 0.0023 0.0014 0.0032
Echinococcus granulosus disco interacting protein 2 0.0041 0.0042 0.01
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0005 0.0005
Giardia lamblia Sgs1 DNA helicase, putative 0.0046 0.0049 0.0169
Brugia malayi Bromodomain containing protein 0.004 0.004 0.005
Plasmodium vivax flap endonuclease 1, putative 0.0078 0.0097 0.0345
Entamoeba histolytica hypothetical protein 0.011 0.0144 0.0925
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0029 0.0028
Echinococcus granulosus histone lysine methyltransferase setb 0.007 0.0085 0.0203
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.0027
Mycobacterium leprae Probable pyruvate kinase PykA 0.0033 0.0029 0.0795
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0059 0.0141
Schistosoma mansoni nocturnin 0.0016 0.0003 0.0007
Trypanosoma brucei PAB1-binding protein , putative 0.0078 0.0097 0.0344
Schistosoma mansoni lamin 0.0055 0.0063 0.0149
Loa Loa (eye worm) pyruvate kinase 0.0033 0.0029 0.0323
Plasmodium vivax hypothetical protein, conserved 0.0031 0.0027 0.0087
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.0096 0.0341
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0054 0.0061 0.0213
Onchocerca volvulus Pyruvate kinase homolog 0.0033 0.0029 0.0028
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0016 0.0039
Schistosoma mansoni smad 0.0018 0.0007 0.0017
Schistosoma mansoni smad 0.0041 0.0042 0.0099
Echinococcus multilocularis mothers against decapentaplegic 5 0.0041 0.0042 0.01
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.0096 0.0671
Schistosoma mansoni DNA helicase recq5 0.0046 0.0049 0.0117
Onchocerca volvulus 0.0048 0.0052 0.005
Schistosoma mansoni smad1 5 8 and 0.0041 0.0042 0.0099
Schistosoma mansoni bromodomain containing protein 0.0018 0.0006 0.0014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0011 0.0026
Echinococcus multilocularis disco interacting protein 2 0.0041 0.0042 0.01
Schistosoma mansoni lipoxygenase 0.0057 0.0065 0.0156
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0049 0.0118
Toxoplasma gondii SWI2/SNF2 Brahma-like putative 0.0021 0.0011 0.003
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0028 0.0022 0.007
Echinococcus multilocularis synaptojanin 1 0.0016 0.0003 0.0008
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0054 0.0061 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.0194 0.027 0.3221
Schistosoma mansoni pyruvate kinase 0.0033 0.0029 0.0069
Loa Loa (eye worm) hypothetical protein 0.0147 0.0199 0.2243
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0031 0.0027 0.0064
Schistosoma mansoni cript-related 0.0016 0.0003 0.0007
Trypanosoma cruzi pyruvate kinase 2, putative 0.0033 0.0029 0.0095
Plasmodium vivax DNA repair protein REV1, putative 0.0028 0.0022 0.007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0121
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0127 0.017 0.0407
Leishmania major hypothetical protein, conserved 0.0032 0.0028 0.0092
Schistosoma mansoni hypothetical protein 0.0127 0.017 0.0407
Loa Loa (eye worm) endonuclease/Exonuclease/phosphatase 0.0016 0.0003 0.0032
Echinococcus multilocularis PHD finger protein rhinoceros 0.0031 0.0027 0.0064
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0025 0.0018 0.0042
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0031 0.0101
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0936 0.1382 1
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.0096 0.0127
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0015
Schistosoma mansoni DNA polymerase eta 0.0116 0.0154 0.0368
Mycobacterium tuberculosis Probable esterase LipL 0.0147 0.0199 0.1422
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0023 0.0014 0.0155
Loa Loa (eye worm) hypothetical protein 0.0018 0.0007 0.0079
Entamoeba histolytica recQ family DNA helicase 0.0024 0.0015 0.0088
Schistosoma mansoni lamin 0.0055 0.0063 0.0149
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0031 0.0073
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.001 0.0082
Plasmodium falciparum exonuclease I, putative 0.0016 0.0004 0.0008
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0033 0.0029 0.0187
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0091 0.0116 0.0279
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0011 0.0026
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.0096 0.023
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0032 0.0356
Schistosoma mansoni Smad4 0.0041 0.0042 0.0099

Activities

Activity type Activity value Assay description Source Reference
Decrease in SBP (functional) NA 0 mmHg Antihypertensive activity as fall in systolic blood pressure after 5 h of 1 umol/kg po dosing in Spontaneously hypertensive rats;NS means nonsignificant change in blood pressure. ChEMBL. 6620302
Decrease in SBP (functional) = 13 mmHg Antihypertensive activity as fall in systolic blood pressure after 1 h of 1 umol/kg po dosing in Spontaneously hypertensive rats. ChEMBL. 6620302
Decrease in SBP (functional) = 14 mmHg Antihypertensive activity as fall in systolic blood pressure after 3 h of 1 umol/kg po dosing in Spontaneously hypertensive rats. ChEMBL. 6620302
Decrease in SBP (functional) = 27 mmHg Antihypertensive activity as fall in systolic blood pressure after 5 h of 10 uM/kg po dosing in Spontaneously hypertensive rats. ChEMBL. 6620302
Decrease in SBP (functional) = 36 mmHg Antihypertensive activity as fall in systolic blood pressure after 3 h of 10 uM/kg po dosing in Spontaneously hypertensive rats. ChEMBL. 6620302
Decrease in SBP (functional) = 40 mmHg Antihypertensive activity as fall in systolic blood pressure after 1 h of 10 uM/kg po dosing in Spontaneously hypertensive rats. ChEMBL. 6620302
ED30 (functional) = 0.03 uM kg-1 Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure ChEMBL. 6620302
ED30 (functional) = 0.06 uM kg-1 Hypotensive activity in anesthetized rats, dose that produced a 30% fall in mean blood pressure after 30 minutes ChEMBL. 6620302

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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