Detailed information for compound 61482

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 247.333 | Formula: C15H21NO2
  • H donors: 0 H acceptors: 0 LogP: 2.21 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCOC2[C@H]1CCc1c2cc(cc1)OC
  • InChi: 1S/C15H21NO2/c1-3-16-8-9-18-15-13-10-12(17-2)6-4-11(13)5-7-14(15)16/h4,6,10,14-15H,3,5,7-9H2,1-2H3/t14-,15?/m1/s1
  • InChiKey: OAKLFHJAYUJWKR-GICMACPYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine receptor Starlite/ChEMBL References
Rattus norvegicus Adrenergic receptor alpha-2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 467 aa 25.1 %
Echinococcus granulosus alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 476 aa 21.0 %
Loa Loa (eye worm) TYRA-2 protein Adrenergic receptor alpha-2   450 aa 488 aa 23.8 %
Onchocerca volvulus Adrenergic receptor alpha-2   450 aa 420 aa 19.8 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Adrenergic receptor alpha-2   450 aa 473 aa 24.1 %
Echinococcus granulosus biogenic amine 5HT receptor Adrenergic receptor alpha-2   450 aa 423 aa 31.7 %
Echinococcus multilocularis fmrfamide receptor Adrenergic receptor alpha-2   450 aa 366 aa 19.9 %
Schistosoma mansoni amine GPCR Adrenergic receptor alpha-2   450 aa 439 aa 29.2 %
Schistosoma mansoni biogenic amine (5HT) receptor Adrenergic receptor alpha-2   450 aa 433 aa 27.9 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Dopamine receptor   475 aa 405 aa 33.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Adrenergic receptor alpha-2   450 aa 378 aa 20.9 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Dopamine receptor   475 aa 398 aa 34.2 %
Echinococcus multilocularis alpha 1A adrenergic receptor Adrenergic receptor alpha-2   450 aa 478 aa 20.7 %
Echinococcus multilocularis serotonin receptor Adrenergic receptor alpha-2   450 aa 426 aa 31.9 %
Echinococcus multilocularis neuropeptides capa receptor Adrenergic receptor alpha-2   450 aa 486 aa 20.6 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamyl-tRNA(Gln) amidotransferase subunit A 0.0014 0.0012 0.0035
Echinococcus granulosus cathepsin L 0.0012 0.0004 0.0012
Echinococcus multilocularis rab protein 3 0.002 0.0039 0.0109
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Brugia malayi Papain family cysteine protease containing protein 0.0048 0.0159 0.0315
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0069 0.025 0.0246
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.0014 0.003
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0057 0.0158
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0016 0.002 0.0049
Brugia malayi neuropeptide F receptor 0.0017 0.0023 0.0038
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0017 0.0023 0.0068
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.079 0.3365 1
Brugia malayi mbt repeat family protein 0.0103 0.0397 0.0797
Loa Loa (eye worm) hypothetical protein 0.0036 0.0107 0.0103
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0128 0.038
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Echinococcus granulosus g protein coupled receptor 0.0017 0.0023 0.0068
Echinococcus granulosus smad 0.0016 0.0022 0.0065
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0067 0.0187
Brugia malayi steroid hormone receptor 0.0021 0.0042 0.0076
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0067 0.0199
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0042 0.0124
Onchocerca volvulus 0.0048 0.0159 0.0159
Trypanosoma cruzi ISWI complex protein 0.0034 0.0099 0.0282
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0036 0.0107 0.0317
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0023 0.0064
Echinococcus multilocularis para nitrobenzyl esterase 0.0051 0.017 0.0475
Trypanosoma cruzi amidase, putative 0.0014 0.0012 0.0024
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0023 0.0068
Onchocerca volvulus 0.002 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0034 0.0096 0.0092
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0159 0.0462
Loa Loa (eye worm) TYRA-2 protein 0.0017 0.0023 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0116 0.0344
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0023 0.0068
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.025 0.0742
Giardia lamblia Cathepsin B precursor 0.0053 0.018 0.0523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis dro:myosuppressin receptor 0.0017 0.0023 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Schistosoma mansoni hypothetical protein 0.002 0.0039 0.0116
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis dnaJ subfamily B 0.0423 0.178 0.4977
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0038 0.0116 0.0324
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0023 0.0068
Brugia malayi Dopamine receptor protein 2 0.0017 0.0023 0.0038
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.079 0.3365 1
Onchocerca volvulus 0.0017 0.0023 0.0022
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0048 0.0159 0.0155
Loa Loa (eye worm) transcriptional regulator 0.0016 0.002 0.0016
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0068
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0103 0.0397 0.0397
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0017 0.0023 0.0068
Echinococcus multilocularis allatostatin A receptor 0.0017 0.0023 0.0064
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0057 0.0135
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0051 0.017 0.0475
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0012 0.0004 0.0012
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0117 0.0454 0.1271
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Brugia malayi Serotonin receptor 0.0017 0.0023 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0042 0.0076
Brugia malayi hypothetical protein 0.0016 0.0021 0.0035
Leishmania major hypothetical protein, conserved 0.002 0.0039 0.0081
Echinococcus granulosus dro:myosuppressin receptor 0.0017 0.0023 0.0068
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0068
Echinococcus granulosus eukaryotic initiation factor 4A 0.079 0.3365 1
Schistosoma mansoni cathepsin S (C01 family) 0.0012 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0159 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.006 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0039 0.0104
Echinococcus granulosus polycomb protein SCMH1 0.0103 0.0397 0.1181
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0016 0.002 0.0025
Mycobacterium ulcerans Sir2-like regulatory protein 0.0016 0.002 0.0067
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0057 0.4651
Echinococcus multilocularis geminin 0.0173 0.0696 0.1947
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0144 0.0573 0.1701
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Brugia malayi Amidase family protein 0.0014 0.0012 0.0016
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0042 0.0038
Schistosoma mansoni histamine h1 receptor 0.0017 0.0023 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.025 0.0742
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0026 0.0042
Echinococcus granulosus glutamyl tRNAGln amidotransferase subunit A 0.0014 0.0012 0.0035
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0068
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0022 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0036 0.0107 0.0208
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0017 0.0023 0.0038
Brugia malayi Bromodomain containing protein 0.0169 0.0682 0.1374
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0057 0.0355
Echinococcus granulosus somatostatin receptor 0.0017 0.0023 0.0068
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Brugia malayi Bromodomain containing protein 0.0086 0.0321 0.0642
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.03 0.1246 0.1242
Onchocerca volvulus 0.0012 0.0004 0.0003
Echinococcus granulosus tachykinin peptides receptor 99D 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0078 0.0287 0.0283
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0012 0.0004 0.0012
Trypanosoma cruzi cruzipain precursor, putative 0.0015 0.0014 0.003
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0042 0.0076
Onchocerca volvulus 0.0103 0.0397 0.0397
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Loa Loa (eye worm) hypothetical protein 0.0025 0.006 0.0056
Echinococcus granulosus acetylcholinesterase 0.03 0.1246 0.3702
Onchocerca volvulus 0.003 0.008 0.0079
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0004 0.0012
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0023 0.0064
Entamoeba histolytica hypothetical protein, conserved 0.0016 0.002 0.0049
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0057 0.0108
Brugia malayi Cathepsin L-like precursor 0.0048 0.0159 0.0315
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus multilocularis cysteine protease 0.0048 0.0159 0.0446
Schistosoma mansoni biogenic amine receptor 0.0017 0.0023 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0042 0.0124
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0144 0.0573 0.1692
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0004 0.0012
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Plasmodium vivax SET domain protein, putative 0.0031 0.0085 0.0242
Echinococcus multilocularis g-protein coupled receptor 0.0017 0.0023 0.0064
Echinococcus granulosus carboxylesterase 5A 0.03 0.1246 0.3702
Leishmania major hypothetical protein, conserved 0.0025 0.006 0.0143
Echinococcus multilocularis zinc finger protein 0.0045 0.0147 0.0412
Entamoeba histolytica hypothetical protein 0.002 0.0039 0.0104
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Trypanosoma brucei SIR2-like protein 4, putative 0.0016 0.002 0.0025
Brugia malayi Carboxylesterase family protein 0.03 0.1246 0.2516
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0476 0.2007 0.2004
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0109 0.042 0.1239
Schistosoma mansoni cpg binding protein 0.003 0.008 0.0237
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0057 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0017 0.0023 0.0038
Onchocerca volvulus 0.0017 0.0023 0.0022
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0582 0.1731
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0159 0.0462
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0109 0.042 0.1239
Schistosoma mansoni hypothetical protein 0.0423 0.178 0.529
Echinococcus multilocularis ras-related protein rab-5 0.002 0.0039 0.0109
Schistosoma mansoni amidase 0.0117 0.0454 0.1351
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0017 0.0023 0.0068
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0109 0.042 0.1175
Echinococcus multilocularis cathepsin L 0.0012 0.0004 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0067 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0067 0.0187
Mycobacterium ulcerans hypothetical protein 0.0025 0.0057 0.0355
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0048 0.0159 0.0155
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0053
Schistosoma mansoni methyl-cpg binding protein mbd 0.0038 0.0116 0.0344
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0067 0.0164
Brugia malayi Dopamine receptor protein 1 0.0017 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.001
Echinococcus granulosus para nitrobenzyl esterase 0.0051 0.017 0.0505
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0057 0.0135
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0223 0.0651
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0023 0.0068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0027 0.0067 0.0164
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0128 1
Onchocerca volvulus 0.0051 0.017 0.0169
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Onchocerca volvulus 0.0048 0.0159 0.0159
Trypanosoma cruzi Rab-like 5, small G protein 0.002 0.0039 0.0104
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0068
Onchocerca volvulus 0.0017 0.0023 0.0022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0004 0.0012
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0034 0.0096 0.0275
Plasmodium falciparum glutamyl-tRNA(Gln) amidotransferase subunit A 0.0014 0.0012 0.0024
Loa Loa (eye worm) amidase 0.0014 0.0012 0.0008
Loa Loa (eye worm) cysteine protease 0.0048 0.0159 0.0155
Brugia malayi Carboxylesterase family protein 0.0051 0.017 0.0336
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0027 0.0067 0.0187
Plasmodium vivax glutamyl-tRNA(Gln) amidotransferase subunit A, putative 0.0014 0.0012 0.0024
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0128 0.0369
Loa Loa (eye worm) amidase 0.0014 0.0012 0.0008
Onchocerca volvulus 0.0017 0.0023 0.0022
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0014 0.002
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.003 1
Brugia malayi Cathepsin L-like precursor 0.0048 0.0159 0.0315
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0017 0.0023 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0223 0.0662
Echinococcus granulosus allatostatin A receptor 0.0017 0.0023 0.0068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0223 0.1652
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0057 0.0355
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0023 0.0064
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.002 0.0061
Echinococcus multilocularis neuropeptide s receptor 0.056 0.2371 0.6628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0067 0.0187
Echinococcus multilocularis chromatin regulatory protein sir2 0.0109 0.042 0.1175
Echinococcus granulosus cathepsin L 0.0027 0.0067 0.0199
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0159 0.0462
Trypanosoma brucei Rab-like 5, small G protein 0.002 0.0039 0.0081
Toxoplasma gondii cathepsin B 0.0053 0.018 0.0523
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0128 0.0369
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0128 0.0357
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.003 0.0055
Onchocerca volvulus 0.0051 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0128 0.0346
Echinococcus granulosus cathepsin L cysteine protease 0.0027 0.0067 0.0199
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0017 0.0023 0.0038
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0023 0.0064
Echinococcus granulosus chromatin regulatory protein sir2 0.0109 0.042 0.1249
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0017 0.0023 0.0068
Entamoeba histolytica cysteine proteinase, putative 0.0027 0.0067 0.0187
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0017 0.0023 0.0019
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0016 0.002 0.0057
Loa Loa (eye worm) MBCTL1 0.0118 0.0459 0.0455
Echinococcus granulosus BC026374 protein S09 family 0.0051 0.017 0.0505
Echinococcus granulosus neuropeptide s receptor 0.056 0.2371 0.7045
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0023 0.0064
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0015 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus granulosus hypothetical protein 0.0017 0.0023 0.0068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.025 0.0742
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0159 0.0159
Trichomonas vaginalis GTP binding protein rare7l, putative 0.002 0.0039 0.0104
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0023 0.0064
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0223 0.0623
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Onchocerca volvulus 0.0017 0.0023 0.0022
Schistosoma mansoni cpg binding protein 0.0036 0.0105 0.0313
Brugia malayi putative neuropeptide receptor NPR1 0.0017 0.0023 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Echinococcus multilocularis cathepsin L cysteine protease 0.0048 0.0159 0.0446
Brugia malayi Pre-SET motif family protein 0.0031 0.0085 0.0165
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0085 0.0254
Brugia malayi Melatonin receptor type 1A 0.0017 0.0023 0.0038
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0085 0.0254
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0118 0.0459 0.1284
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0016 0.002 0.0057
Echinococcus multilocularis cathepsin L 0.0027 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis neuropeptides capa receptor 0.0017 0.0023 0.0064
Giardia lamblia Sirtuin type 2 0.0016 0.002 0.0049
Brugia malayi ecdysteroid receptor 0.0021 0.0042 0.0076
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0048 0.0159 0.0462
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0397 0.1181
Loa Loa (eye worm) hypothetical protein 0.0117 0.0454 0.0451
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0051 0.017 0.0471
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0064
Brugia malayi ORL1-like opioid receptor 0.0017 0.0023 0.0038
Echinococcus multilocularis g protein coupled receptor 0.0017 0.0023 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0042 0.0116
Echinococcus multilocularis SAM and MBT domain containing protein 0.0103 0.0397 0.1111
Entamoeba histolytica cysteine proteinase, putative 0.0048 0.0159 0.0462
Schistosoma mansoni cathepsin F (C01 family) 0.0048 0.0159 0.0474
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.008 0.0076
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0109 0.042 0.1239
Plasmodium vivax NAD-dependent deacetylase, putative 0.0016 0.002 0.0049
Loa Loa (eye worm) hypothetical protein 0.0103 0.0397 0.0394
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0042 0.0076
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0223 0.1652
Onchocerca volvulus 0.0051 0.017 0.0169
Brugia malayi GnHR receptor homolog 0.0017 0.0023 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Echinococcus granulosus acetylcholinesterase 0.03 0.1246 0.3702
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0035
Mycobacterium tuberculosis Carboxylesterase LipT 0.0051 0.017 0.0471
Echinococcus granulosus cysteine protease 0.0027 0.0067 0.0199
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.002 0.0033
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Onchocerca volvulus 0.0017 0.0023 0.0022
Brugia malayi Cathepsin L-like precursor 0.0048 0.0159 0.0315
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0057 0.0158
Loa Loa (eye worm) inositol-1 0.0041 0.0128 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0042 0.0076
Brugia malayi cathepsin B-like cysteine proteinase 0.0144 0.0573 0.1152
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0023 0.0064
Schistosoma mansoni neuropeptide f receptor 76f 0.0017 0.0023 0.0068
Mycobacterium tuberculosis Probable oxidoreductase 0.0309 0.1288 0.3804
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Brugia malayi putative amidase 0.0014 0.0012 0.0016
Brugia malayi MH1 domain containing protein 0.0016 0.0022 0.0036
Onchocerca volvulus 0.0048 0.0159 0.0159
Brugia malayi mbt repeat family protein 0.0103 0.0397 0.0797
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0109 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0042 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0042 0.0124
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Brugia malayi Smad1 0.0016 0.0022 0.0036
Loa Loa (eye worm) sirtuin 4 0.0016 0.002 0.0016
Schistosoma mansoni fatty-acid amide hydrolase 0.0117 0.0454 0.1351
Echinococcus multilocularis cathepsin L cysteine protease 0.0048 0.0159 0.0446
Schistosoma mansoni adenoreceptor 0.0017 0.0023 0.0068
Echinococcus granulosus neuropeptide FF receptor 2 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Loa Loa (eye worm) mbt repeat family protein 0.0103 0.0397 0.0394
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0057 0.0355
Loa Loa (eye worm) hypothetical protein 0.0158 0.0633 0.063
Entamoeba histolytica cysteine proteinase 2 0.0027 0.0067 0.0187
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.017 0.0505
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0057 0.0135
Giardia lamblia Cathepsin B precursor 0.0053 0.018 0.0523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni hypothetical protein 0.0036 0.0107 0.0317
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.079 0.3365 0.3364
Echinococcus multilocularis histone acetyltransferase MYST2 0.0118 0.0459 0.1284
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0068
Trichomonas vaginalis spcc417.12 protein, putative 0.0051 0.017 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0128 0.0369
Onchocerca volvulus 0.0017 0.0023 0.0022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0023 0.0064
Loa Loa (eye worm) transcriptional regulator 0.0016 0.002 0.0016
Loa Loa (eye worm) cathepsin B 0.0053 0.018 0.0176
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0042 0.0124
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0042 0.0076
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0042 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0042 0.0038
Echinococcus granulosus cathepsin l cysteine peptidase 0.0048 0.0159 0.0474
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0065
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0016 0.002 0.0061
Mycobacterium ulcerans NAD-dependent deacetylase 0.0016 0.002 0.0067
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0167
Schistosoma mansoni opsin-like receptor 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis fmrfamide receptor 0.0017 0.0023 0.0064
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Loa Loa (eye worm) melatonin receptor type 1A 0.0017 0.0023 0.0019
Brugia malayi Amidase family protein 0.0014 0.0012 0.0016
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0022 0.0065
Brugia malayi G-protein coupled receptor 0.0017 0.0023 0.0038
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0128 0.0369
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.017 0.0505
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0052 0.0176 0.0492
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0096 0.0275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0096 0.0275
Loa Loa (eye worm) hypothetical protein 0.079 0.3365 0.3362
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0042 0.0041
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0057 0.0355
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0023 0.0068
Onchocerca volvulus Neuropeptide F receptor homolog 0.0017 0.0023 0.0022
Echinococcus granulosus sex peptide receptor 0.0017 0.0023 0.0068
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0042 0.0124
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Loa Loa (eye worm) carboxylesterase 0.0051 0.017 0.0166
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.006 0.0167
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0053 0.018 0.0534
Schistosoma mansoni myelin transcription factor 1 myt1 0.0118 0.0459 0.1365
Brugia malayi G-protein coupled receptor 0.0017 0.0023 0.0038
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0085 0.0239
Schistosoma mansoni cathepsin B (C01 family) 0.0012 0.0004 0.0012
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0085 0.0242
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Schistosoma mansoni zinc finger protein 0.0045 0.0147 0.0438
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0042 0.0076
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0109 1
Echinococcus multilocularis eukaryotic initiation factor 4A 0.079 0.3365 0.9407
Onchocerca volvulus 0.0017 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0068
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0016 0.002 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0042 0.0076
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0042 0.0124
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0135 0.0534 0.1588
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0042 0.0076
Brugia malayi neuropeptide F receptor 0.0017 0.0023 0.0038
Brugia malayi Serotonin receptor 0.0017 0.0023 0.0038
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0017 0.0023 0.0019
Echinococcus multilocularis cysteine protease 0.0048 0.0159 0.0446
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0053 0.018 0.0523
Plasmodium falciparum cysteine proteinase falcipain 3 0.0048 0.0159 0.0462
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0042 0.0038
Schistosoma mansoni biogenic amine receptor 0.0017 0.0023 0.0068
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0582 0.1628
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Echinococcus granulosus Smad4 0.0016 0.0022 0.0065
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0004 0.0012
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Onchocerca volvulus 0.0017 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0017 0.0023 0.0064
Schistosoma mansoni sex comb on midleg homolog 0.0103 0.0397 0.1181
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0042 0.0124
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0027 0.0067 0.0187
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.0988 0.0984
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0223 0.0629
Echinococcus multilocularis G protein coupled receptor 139 0.0017 0.0023 0.0064
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0042 0.0116
Onchocerca volvulus 0.0017 0.0023 0.0022
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0039 0.0104
Onchocerca volvulus 0.0017 0.0023 0.0022
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0023 0.0019
Echinococcus multilocularis neuropeptide receptor 0.0017 0.0023 0.0064
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.042 0.1249
Schistosoma mansoni neuroligin 3 (S09 family) 0.0051 0.017 0.0505
Echinococcus multilocularis acetylcholinesterase 0.03 0.1246 0.3483
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Onchocerca volvulus 0.0242 0.0996 0.0995
Trypanosoma cruzi ISWI complex protein 0.0034 0.0099 0.0282
Echinococcus granulosus neuropeptide receptor 0.0017 0.0023 0.0068
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0023 0.0068
Echinococcus granulosus SAM and MBT domain containing protein 0.0103 0.0397 0.1181
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0016 0.002 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0042 0.0116
Toxoplasma gondii cathepsin CPL 0.0048 0.0159 0.0462
Schistosoma mansoni neuropeptide F-like receptor 0.0017 0.0023 0.0068
Echinococcus granulosus fatty acid amide hydrolase 1 0.0117 0.0454 0.1351
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0017 0.0023 0.0064
Loa Loa (eye worm) carboxylesterase 0.03 0.1246 0.1242
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0004 0.0012
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Brugia malayi Protein kinase domain containing protein 0.0476 0.2007 0.4058
Trypanosoma cruzi cruzipain precursor, putative 0.0048 0.0159 0.0462
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0048 0.0159 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0479 0.2021 0.6006
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0839 0.3577 1
Schistosoma mansoni acetylcholinesterase 0.0051 0.017 0.0505
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0017 0.0023 0.0068
Onchocerca volvulus 0.0048 0.0159 0.0159
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0068
Schistosoma mansoni alpha-1 adrenergic receptor 0.0017 0.0023 0.0068
Brugia malayi MH2 domain containing protein 0.024 0.0988 0.1994
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0042 0.0124
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0118 0.0459 0.1365
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0012 0.0004 0.0012
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0067 0.0199
Plasmodium vivax ras-related protein Rab-5A, putative 0.002 0.0039 0.0104
Echinococcus multilocularis GTP binding protein Parf 0.002 0.0039 0.0109
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0167
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0057 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0048 0.0159 0.0159
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0068
Schistosoma mansoni hypothetical protein 0.0036 0.0107 0.0317
Brugia malayi Carboxylesterase family protein 0.0051 0.017 0.0336
Schistosoma mansoni bromodomain containing protein 0.0143 0.0569 0.1691
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0067 0.0187
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Leishmania major sir2-family protein-like protein 0.0016 0.002 0.0025
Brugia malayi Cathepsin L-like precursor 0.0034 0.0096 0.0187
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.002 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0057 0.0108
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Onchocerca volvulus 0.0051 0.017 0.0169
Loa Loa (eye worm) hypothetical protein 0.0118 0.0459 0.0455
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0128 0.0369
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0067 0.0128
Brugia malayi hypothetical protein 0.0025 0.006 0.0113
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.006 0.0167
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0017 0.0023 0.0068
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0057 0.0108
Echinococcus granulosus serotonin receptor 0.0017 0.0023 0.0068
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.008 0.0298 0.0885
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0023 0.0064
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0042 0.0124
Schistosoma mansoni hypothetical protein 0.0173 0.0696 0.207
Plasmodium falciparum cysteine proteinase falcipain 1 0.0027 0.0067 0.0187
Schistosoma mansoni inositol monophosphatase 0.0041 0.0128 0.038
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0023 0.0068
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.079 0.3365 1
Onchocerca volvulus 0.0017 0.0023 0.0022
Entamoeba histolytica cysteine proteinase 1, putative 0.0027 0.0067 0.0187
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0016 0.002 0.0057
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.0016
Brugia malayi follicle stimulating hormone receptor 0.0017 0.0023 0.0038
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0042 0.0116
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0476 0.2007 0.5611
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0027 0.0067 0.0199
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0023 0.0068
Brugia malayi Papain family cysteine protease containing protein 0.0027 0.0067 0.0128
Echinococcus multilocularis serotonin receptor 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0109 0.042 0.1249
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0128 0.0369
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0036 0.0107 0.0317
Trichomonas vaginalis set domain proteins, putative 0.0242 0.0996 0.2951
Loa Loa (eye worm) transcriptional regulator 0.0109 0.042 0.0416
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0017 0.0023 0.0064
Onchocerca volvulus 0.0021 0.0042 0.0041
Loa Loa (eye worm) carboxylesterase 0.0051 0.017 0.0166
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0016 0.002 0.0049
Leishmania major eukaryotic initiation factor 4a, putative 0.079 0.3365 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0057 0.0355
Plasmodium falciparum ras-related protein Rab-5A 0.002 0.0039 0.0104
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.079 0.3365 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus granulosus methyl CpG binding domain protein 2 0.0038 0.0116 0.0344
Brugia malayi Latrophilin receptor protein 2 0.0036 0.0107 0.0208
Brugia malayi Dopamine receptor 0.0017 0.0023 0.0038
Loa Loa (eye worm) Smad1 0.0016 0.0022 0.0018
Schistosoma mansoni opsin-like receptor 0.0017 0.0023 0.0068
Trypanosoma cruzi amidase, putative 0.0014 0.0012 0.0024
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0016 0.002 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Onchocerca volvulus 0.0048 0.0159 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0042 0.0076
Plasmodium vivax vivapain-3 0.0027 0.0067 0.0187
Echinococcus granulosus histone acetyltransferase MYST2 0.0118 0.0459 0.1365
Loa Loa (eye worm) ctsf protein 0.0048 0.0159 0.0155
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0042 0.0038
Schistosoma mansoni hypothetical protein 0.0036 0.0107 0.0317
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.0988 0.0984
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0096 0.0286
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0053 0.018 0.0501
Brugia malayi eukaryotic initiation factor 4A 0.079 0.3365 0.6809
Onchocerca volvulus 0.0017 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Echinococcus multilocularis glutamyl tRNA(Gln) amidotransferase subunit A 0.0014 0.0012 0.0033
Brugia malayi Calcitonin receptor-like protein seb-1 0.0114 0.0443 0.0889
Leishmania major cysteine peptidase A (CPA) 0.0048 0.0159 0.044
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.079 0.3365 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0057 0.0135
Echinococcus granulosus geminin 0.0173 0.0696 0.207
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.079 0.3365 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0582 0.1731
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis serotonin receptor 0.0017 0.0023 0.0064
Echinococcus granulosus G protein coupled receptor 139 0.0017 0.0023 0.0068
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0042 0.0116
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Schistosoma mansoni hypothetical protein 0.0078 0.0287 0.0854
Brugia malayi nuclear hormone receptor 0.0021 0.0042 0.0076
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0022 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Echinococcus granulosus g protein coupled receptor 0.0017 0.0023 0.0068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.079 0.3365 1
Toxoplasma gondii histone deacetylase SIR2 0.0016 0.002 0.0049
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0042 0.0076
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0042 0.0038
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Echinococcus multilocularis neuroligin 0.0051 0.017 0.0475
Schistosoma mansoni coup transcription factor 0.0021 0.0042 0.0124
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0023 0.0019
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0017 0.0023 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0091 0.0344 0.034
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0042 0.0116
Schistosoma mansoni gliotactin 0.0051 0.017 0.0505
Brugia malayi Inositol-1 0.0041 0.0128 0.0251
Echinococcus multilocularis BC026374 protein (S09 family) 0.0051 0.017 0.0475
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0223 0.1652
Trypanosoma brucei ISWI complex protein 0.0034 0.0099 0.0259
Echinococcus multilocularis cathepsin b 0.0144 0.0573 0.1601
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0053
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0096 0.0275
Echinococcus granulosus orexin receptor type 2 0.0017 0.0023 0.0068
Echinococcus granulosus 7TM GPCR rhodopsin 0.0017 0.0023 0.0068
Echinococcus granulosus neuropeptide receptor 0.0017 0.0023 0.0068
Brugia malayi Carboxylesterase family protein 0.03 0.1246 0.2516
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0014 0.0012 0.0033
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.002 0.0039 0.0038
Echinococcus multilocularis neuropeptide receptor A26 0.056 0.2371 0.6628
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Leishmania major hypothetical protein, conserved 0.002 0.0039 0.0081
Trypanosoma cruzi cysteine protease, putative 0.0027 0.0067 0.0187
Brugia malayi larval opioid receptor 0.0017 0.0023 0.0038
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0057 0.0355
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Brugia malayi AKH receptor 0.0017 0.0023 0.0038
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0017 0.0023 0.0019
Mycobacterium ulcerans short chain dehydrogenase 0.0309 0.1288 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0144 0.0573 0.1701
Mycobacterium ulcerans carboxylesterase, LipT 0.0051 0.017 0.1239
Loa Loa (eye worm) latrophilin receptor protein 2 0.0036 0.0107 0.0103
Schistosoma mansoni hypothetical protein 0.0046 0.015 0.0447
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0109 0.042 0.1218
Loa Loa (eye worm) fibroinase 0.0048 0.0159 0.0155
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0109 0.042 0.1239
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0022 0.0061
Entamoeba histolytica cysteine protease, putative 0.0048 0.0159 0.0462
Echinococcus granulosus g-protein coupled receptor 0.0017 0.0023 0.0068
Trypanosoma cruzi cysteine peptidase, putative 0.0027 0.0067 0.0187
Giardia lamblia Cathepsin B precursor 0.0053 0.018 0.0523
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0017 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0144 0.0573 0.0569
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.008 0.0298 0.0833
Giardia lamblia Translation initiation factor eIF-4A, putative 0.079 0.3365 1
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0122 0.0118
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Echinococcus granulosus g protein coupled receptor 0.0017 0.0023 0.0068
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0582 0.1731
Echinococcus granulosus GPCR family 2 0.0036 0.0107 0.0317
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0017 0.0023 0.0068
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0048 0.0159 0.0462
Plasmodium vivax hypothetical protein, conserved 0.0016 0.002 0.0049
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0146 0.0582 0.1172
Echinococcus granulosus cathepsin b 0.0144 0.0573 0.1701
Plasmodium falciparum eukaryotic initiation factor 4A 0.079 0.3365 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0017 0.0023 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0042 0.0076
Leishmania major silent information regulator 2, putative 0.0109 0.042 0.1218
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0023 0.0068
Plasmodium vivax vivapain-2 0.0048 0.0159 0.0462
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Echinococcus multilocularis neuropeptide Y receptor 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.042 0.1249
Loa Loa (eye worm) PHD-finger family protein 0.0046 0.015 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Brugia malayi PHD-finger family protein 0.0057 0.0199 0.0395
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0144 0.0573 0.1701
Echinococcus granulosus biogenic amine 5HT receptor 0.0017 0.0023 0.0068
Echinococcus granulosus fatty acid amide hydrolase 1 0.0117 0.0454 0.1351
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.003 0.0079
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0017 0.0023 0.0019
Onchocerca volvulus Cathepsin F homolog 0.0048 0.0159 0.0159
Echinococcus granulosus fetal alzheimer antigen falz 0.0052 0.0176 0.0523
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Echinococcus granulosus neuroligin 0.0051 0.017 0.0505
Brugia malayi Ras-related protein ypt4 0.002 0.0039 0.0071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0228 0.0679
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0015 0.0014 0.001
Brugia malayi Cathepsin L-like precursor 0.0015 0.0014 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.002 0.0049
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0042 0.0124
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0068
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0017 0.0023 0.0038
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0042 0.0124
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0042 0.0041
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.079 0.3365 1
Brugia malayi MH2 domain containing protein 0.0016 0.0022 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0026 0.0042
Echinococcus multilocularis polycomb protein SCMH1 0.0103 0.0397 0.1111
Schistosoma mansoni amine GPCR 0.0017 0.0023 0.0068
Echinococcus multilocularis neuropeptide FF receptor 2 0.0017 0.0023 0.0064
Schistosoma mansoni cathepsin F (C01 family) 0.0048 0.0159 0.0474
Schistosoma mansoni hypothetical protein 0.0017 0.0023 0.0068
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0078 0.0231
Plasmodium vivax vivapain-1 0.0027 0.0067 0.0187
Leishmania major hypothetical protein, conserved 0.0034 0.0099 0.0259
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Loa Loa (eye worm) hypothetical protein 0.0048 0.0159 0.0155
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0022 0.0065
Echinococcus granulosus cathepsin b 0.0144 0.0573 0.1701
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Treponema pallidum ATP-dependent RNA helicase 0.079 0.3365 1
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.006 0.0143
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0042 0.0124
Schistosoma mansoni biogenic amine (5HT) receptor 0.0017 0.0023 0.0068
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.025 0.0698
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0042 0.0124
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0048 0.0159 0.0446
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Onchocerca volvulus 0.0017 0.0023 0.0022
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0036 0.0107 0.0299
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0068
Brugia malayi Cathepsin L-like precursor 0.0034 0.0096 0.0187
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0042 0.0124
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0223 0.0629
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.001
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0042 0.0124
Brugia malayi transcriptional regulator, Sir2 family protein 0.0016 0.002 0.0033
Echinococcus granulosus rab protein 3 0.002 0.0039 0.0116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0057 0.0135
Toxoplasma gondii histone lysine methyltransferase SET1 0.0063 0.0222 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0042 0.0076
Brugia malayi Pre-SET motif family protein 0.0213 0.0869 0.1753
Loa Loa (eye worm) hypothetical protein 0.0097 0.037 0.0366
Echinococcus multilocularis carboxylesterase 5A 0.03 0.1246 0.3483
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0042 0.0038
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.079 0.3365 1
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.003 0.0079
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0114 0.0443 0.0889
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0048 0.0159 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Brugia malayi cathepsin F-like cysteine proteinase 0.0015 0.0014 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Onchocerca volvulus 0.0034 0.0096 0.0096
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0034 0.0096 0.0092
Loa Loa (eye worm) hypothetical protein 0.0086 0.0321 0.0317
Onchocerca volvulus 0.0051 0.017 0.0169
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0017 0.0023 0.0064
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0146 0.0582 0.1628
Echinococcus granulosus GTP binding protein Parf 0.002 0.0039 0.0116
Onchocerca volvulus Epoxide hydrolase 1 homolog 0.2326 1 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Brugia malayi CXXC zinc finger family protein 0.003 0.008 0.0153
Schistosoma mansoni growth hormone secretagogue receptor 0.0017 0.0023 0.0068
Entamoeba histolytica hypothetical protein 0.002 0.0039 0.0104
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0017 0.0023 0.0068
Schistosoma mansoni cpg binding protein 0.0036 0.0105 0.0313
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.03 0.1246 0.3702
Schistosoma mansoni Smad4 0.0016 0.0022 0.0065
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0042 0.0076
Echinococcus multilocularis G-protein coupled receptor, putative 0.0017 0.0023 0.0064
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0159 0.0462
Brugia malayi Carboxylesterase family protein 0.0051 0.017 0.0336
Echinococcus granulosus neuropeptides capa receptor 0.0017 0.0023 0.0068
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0017 0.0023 0.0068
Leishmania major eukaryotic initiation factor 4a, putative 0.079 0.3365 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0042 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni neuropeptide receptor 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Schistosoma mansoni hypothetical protein 0.0628 0.2664 0.7916
Trypanosoma cruzi hypothetical protein, conserved 0.002 0.0039 0.0104
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0051 0.017 0.0494
Giardia lamblia Hypothetical protein 0.0109 0.042 0.1239
Onchocerca volvulus 0.0017 0.0023 0.0022
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0016 0.002 0.0061
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0053
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0019
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0051 0.017 0.0471
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Plasmodium vivax unspecified product 0.0015 0.0014 0.003
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus granulosus fatty acid amide hydrolase 1 0.0014 0.0012 0.0035
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Echinococcus multilocularis somatostatin receptor 0.0017 0.0023 0.0064
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0146 0.0582 0.1731
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0017 0.0023 0.0068
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0407 0.171 0.5081
Echinococcus granulosus cathepsin l1 0.0048 0.0159 0.0474
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0017 0.0023 0.0068
Schistosoma mansoni BC026374 protein (S09 family) 0.0051 0.017 0.0505
Brugia malayi sulfakinin receptor protein 0.0017 0.0023 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0213 0.0869 0.0866
Echinococcus granulosus 7tm_1 domain containing protein 0.0017 0.0023 0.0068
Plasmodium vivax vivapain-2 0.0048 0.0159 0.0462
Brugia malayi latrophilin 2 splice variant baaae 0.0078 0.0287 0.0574
Onchocerca volvulus 0.0025 0.0057 0.0056
Schistosoma mansoni smad1 5 8 and 0.0016 0.0022 0.0065
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0036 0.0107 0.0299
Brugia malayi NAD-dependent deacetylase SIRT1 0.0016 0.002 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0223 0.0662
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0053 0.018 0.0523
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0042 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0022 0.0018
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.042 0.1239
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0052 0.0176 0.0523
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0042 0.0038
Echinococcus granulosus fmrfamide receptor 0.0017 0.0023 0.0068
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0407 0.171 0.478
Echinococcus granulosus cathepsin L cysteine proteinase 0.0048 0.0159 0.0474
Onchocerca volvulus 0.0048 0.0159 0.0159
Brugia malayi hypothetical protein 0.0051 0.017 0.0336
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0035
Onchocerca volvulus 0.0017 0.0023 0.0022
Brugia malayi transcriptional regulator, Sir2 family protein 0.0109 0.042 0.0843
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0128 0.0369
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0103 0.0397 0.1181
Brugia malayi cathepsin L-like precursor 0.0034 0.0096 0.0187
Brugia malayi amidase 0.0117 0.0454 0.0913
Echinococcus granulosus dnaJ subfamily B 0.0423 0.178 0.529
Plasmodium vivax RNA helicase-1, putative 0.079 0.3365 1
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0016 0.002 0.0049
Echinococcus granulosus eukaryotic initiation factor 4A III 0.079 0.3365 1
Echinococcus multilocularis cathepsin b 0.0144 0.0573 0.1601
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0017 0.0023 0.0038
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0118 0.0459 0.0922
Giardia lamblia Transcriptional regulator, Sir2 family 0.0016 0.002 0.0049
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0057 0.4651
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0223 0.0662
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.003 0.0145
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0016 0.002 0.0049
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0146 0.0582 0.0579
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0017 0.0023 0.0068
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Echinococcus multilocularis orexin receptor type 2 0.0017 0.0023 0.0064
Echinococcus multilocularis sex peptide receptor 0.0017 0.0023 0.0064
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Brugia malayi Cathepsin L-like precursor 0.0048 0.0159 0.0315
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0042 0.0124
Onchocerca volvulus 0.0017 0.0023 0.0022
Entamoeba histolytica cysteine protease, putative 0.0027 0.0067 0.0187
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.079 0.3365 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus multilocularis GPCR, family 2 0.0036 0.0107 0.0299
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0051 0.017 0.0505
Trypanosoma brucei cysteine peptidase C (CPC) 0.0053 0.018 0.0501
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0048 0.0159 0.0462
Echinococcus multilocularis smad 0.0016 0.0022 0.0061
Brugia malayi Cathepsin L-like precursor 0.0048 0.0159 0.0315
Plasmodium vivax unspecified product 0.0027 0.0067 0.0187
Loa Loa (eye worm) hypothetical protein 0.0021 0.0042 0.0038
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0146 0.0582 0.1731
Brugia malayi hydrolase, alpha/beta fold family protein 0.1155 0.494 1
Echinococcus granulosus cpg binding protein 0.0036 0.0105 0.0313
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0026 0.0042
Loa Loa (eye worm) acetylcholinesterase 1 0.03 0.1246 0.1242
Brugia malayi MH1 domain containing protein 0.0016 0.0022 0.0036
Schistosoma mansoni cathepsin C 0.0012 0.0004 0.0012
Schistosoma mansoni chromatin regulatory protein sir2 0.0109 0.042 0.1249
Echinococcus granulosus alpha 1A adrenergic receptor 0.0017 0.0023 0.0068
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0012 0.0004 0.0012
Echinococcus multilocularis fatty acid amide hydrolase 1 0.0117 0.0454 0.1271
Brugia malayi RAB, member of RAS oncogene family-like 5 0.002 0.0039 0.0071
Brugia malayi G protein-coupled receptor F59B2.13 0.0017 0.0023 0.0038
Echinococcus granulosus zinc finger protein 0.0045 0.0147 0.0438
Brugia malayi G protein-coupled receptor 0.0017 0.0023 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0159 0.044
Schistosoma mansoni hypothetical protein 0.0036 0.0107 0.0317
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0128 0.0909
Loa Loa (eye worm) hypothetical protein 0.0114 0.0443 0.0439
Schistosoma mansoni cathepsin s 0.0015 0.0014 0.0042
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.079 0.3365 1
Schistosoma mansoni biogenic amine receptor 0.0017 0.0023 0.0068
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0042 0.0116
Onchocerca volvulus 0.0048 0.0159 0.0159
Brugia malayi RE15519p 0.0017 0.0023 0.0038
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.079 0.3365 0.9407
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0042 0.0124
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.006 0.0167
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.03 0.1246 0.1242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0048 0.0159 0.0462
Schistosoma mansoni hypothetical protein 0.0034 0.0099 0.0294
Toxoplasma gondii histone deacetylase SIR2-like 0.0016 0.002 0.0049
Brugia malayi Cathepsin L-like cysteine proteinase 0.0034 0.0096 0.0187
Echinococcus granulosus rhodopsin orphan GPCR 0.0017 0.0023 0.0068
Brugia malayi MH2 domain containing protein 0.0016 0.0022 0.0036
Brugia malayi hypothetical protein 0.002 0.0039 0.0071
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0128 0.0346
Echinococcus granulosus tm gpcr rhodopsin 0.0017 0.0023 0.0068
Echinococcus multilocularis cpg binding protein 0.0036 0.0105 0.0295
Echinococcus multilocularis rhodopsin orphan GPCR 0.0017 0.0023 0.0064
Loa Loa (eye worm) hypothetical protein 0.0034 0.0096 0.0092
Brugia malayi putative neuropeptide receptor 0.0017 0.0023 0.0038
Brugia malayi Cathepsin L-like precursor 0.0048 0.0159 0.0315
Leishmania major cathepsin L-like protease 0.0048 0.0159 0.044
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0039 0.0104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0017 0.0023 0.0068
Echinococcus granulosus peptide allatostatin:somatostatin 0.0017 0.0023 0.0068
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0042 0.0124
Trichomonas vaginalis hypothetical protein 0.002 0.0039 0.0104
Echinococcus multilocularis Smad4 0.0016 0.0022 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0042 0.0076
Brugia malayi nuclear receptor NHR-88 0.0021 0.0042 0.0076
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0026 0.0042
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0051 0.017 0.0505
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0026
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0016 0.002 0.0061
Schistosoma mansoni fatty-acid amide hydrolase 0.0014 0.0012 0.0035
Schistosoma mansoni myosin xvIII 0.0017 0.0023 0.0068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0048 0.0159 0.0446
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0016 0.002 0.0049
Brugia malayi Carboxylesterase family protein 0.0051 0.017 0.0336
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0042 0.0076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0042 0.0124
Schistosoma mansoni smad 0.0016 0.0022 0.0065
Loa Loa (eye worm) G-protein coupled receptor 0.0017 0.0023 0.0019
Onchocerca volvulus Cathepsin L homolog 0.0012 0.0004 0.0003
Schistosoma mansoni zinc finger protein 0.0034 0.0099 0.0294
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0017 0.0023 0.0064
Echinococcus granulosus cathepsin l1 0.0034 0.0096 0.0286
Brugia malayi Tachykinin-like peptides receptor 99D 0.0017 0.0023 0.0038
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0042 0.0124
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.002 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.0017 0.0023 0.0019
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0016 0.002 0.0049
Brugia malayi hypothetical protein 0.0017 0.0023 0.0038
Echinococcus granulosus neuropeptide Y receptor 0.0017 0.0023 0.0068
Onchocerca volvulus 0.0031 0.0085 0.0085
Schistosoma mansoni hypothetical protein 0.0173 0.0696 0.207
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0114 0.0443 0.0439
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0135 0.0534 0.1494
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0017 0.0023 0.0019
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0144 0.0573 0.1701
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0109 0.042 0.1239
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0022 0.0018
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0042 0.0116
Schistosoma mansoni opsin-like receptor 0.0017 0.0023 0.0068
Loa Loa (eye worm) hypothetical protein 0.0051 0.017 0.0166
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0042 0.0116
Schistosoma mansoni inositol monophosphatase 0.0041 0.0128 0.038
Echinococcus multilocularis acetylcholinesterase 0.03 0.1246 0.3483
Schistosoma mansoni chromatin regulatory protein sir2 0.0016 0.002 0.0061
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0035
Echinococcus granulosus neuropeptide receptor A26 0.056 0.2371 0.7045
Trypanosoma cruzi cysteine proteinase, putative 0.0027 0.0067 0.0187

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.16 mg kg-1 Determination of ED50 for induction of turning contralateral in 6-hydroxydopamine (6-OHDA) lesioned rats by ip administration ChEMBL. 6094811
ED50 (functional) = 0.16 mg kg-1 Determination of ED50 for induction of turning contralateral in 6-hydroxydopamine (6-OHDA) lesioned rats by ip administration ChEMBL. 6094811
IC50 (binding) = 200 nM Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]-clonidine from specific binding sites on rat striatal membranes ChEMBL. 6094811
IC50 (binding) = 200 nM Alpha-2 adrenergic receptor activity assessed in vitro for displacement of [3H]-clonidine from specific binding sites on rat striatal membranes ChEMBL. 6094811
IC50 (binding) = 1242 nM Dopaminergic activity assessed in vitro for displacement of [3H]-apomorphine from specific binding sites on rat striatal membranes ChEMBL. 6094811
IC50 (binding) = 1242 nM Dopaminergic activity assessed in vitro for displacement of [3H]-apomorphine from specific binding sites on rat striatal membranes ChEMBL. 6094811

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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