Detailed information for compound 68923

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 323.814 | Formula: C17H22ClNO3
  • H donors: 0 H acceptors: 1 LogP: 4.06 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(Oc1cccc(c1)Cl)C)OC1CC2CCC(C1)N2C
  • InChi: 1S/C17H22ClNO3/c1-11(21-15-5-3-4-12(18)8-15)17(20)22-16-9-13-6-7-14(10-16)19(13)2/h3-5,8,11,13-14,16H,6-7,9-10H2,1-2H3
  • InChiKey: FLWSYAAWZPXTAN-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0089 0.0057 0.0552
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0083 0.0051 0.1258
Echinococcus granulosus protein will die slowly 0.0205 0.0179 0.0179
Schistosoma mansoni hypothetical protein 0.0112 0.0081 0.0081
Mycobacterium tuberculosis Probable thioesterase TesA 0.0072 0.0039 0.0955
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0752 0.0753 1
Schistosoma mansoni inhibitor of apoptosis protein 0.0112 0.0081 0.0081
Echinococcus multilocularis integrin beta 2 0.2662 0.276 0.3449
Brugia malayi neuroendocrine convertase 1 precursor 0.6037 0.6305 0.6304
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.008 0.008
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0157 0.0129 0.0207
Mycobacterium ulcerans dehydrogenase 0.012 0.009 0.1804
Loa Loa (eye worm) hypothetical protein 0.0045 0.0011 0.0011
Loa Loa (eye worm) AMP-binding enzyme family protein 0.008 0.0048 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Loa Loa (eye worm) hypothetical protein 0.0097 0.0066 0.0066
Trypanosoma cruzi UDP-galactopyranose mutase 0.012 0.009 0.0471
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0246 0.0222 0.2374
Mycobacterium ulcerans polyketide synthase 0.0088 0.0056 0.0939
Brugia malayi ADAMTS-like protease 0.0052 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5842 0.6099 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0111 0.008 0.008
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.005 0.0016 0.0016
Schistosoma mansoni protein kinase 0.014 0.011 0.011
Giardia lamblia Tenascin-like 0.0092 0.006 0.012
Giardia lamblia Tenascin-X 0.0092 0.006 0.012
Echinococcus granulosus fibrillin 2 0.0092 0.006 0.006
Echinococcus multilocularis growth factor receptor bound protein 2 0.0127 0.0097 0.0121
Plasmodium vivax subtilisin-like serine protease, putative 0.042 0.0405 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0092 0.006 0.006
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0051 0.0017 0.0421
Giardia lamblia Hypothetical protein 0.0752 0.0753 0.2024
Giardia lamblia Neurogenic locus Notch protein precursor 0.0092 0.006 0.012
Schistosoma mansoni site-1 peptidase (S08 family) 0.042 0.0405 0.0405
Schistosoma mansoni furin-1 (S08 family) 0.4134 0.4306 0.4306
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Onchocerca volvulus 0.0037 0.0002 0.0036
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0157 0.0129 0.3179
Brugia malayi Subtilase family protein 0.042 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.005 0.0016 0.0016
Toxoplasma gondii bicoid-interacting protein BIN3 0.0089 0.0057 0.1396
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.012 0.009 0.2207
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.005 0.0016 0.002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5842 0.6099 0.7623
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0752 0.0753 0.1231
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0125 0.0095 0.2349
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.0017 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Loa Loa (eye worm) hypothetical protein 0.012 0.009 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Echinococcus multilocularis integrin alpha 3 0.0347 0.0328 0.041
Brugia malayi Protein arginine N-methyltransferase 0.0089 0.0057 0.0057
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.0092 0.006 0.0094
Schistosoma mansoni hypothetical protein 0.0095 0.0063 0.0063
Brugia malayi transcriptional regulator, Sir2 family protein 0.0111 0.008 0.008
Toxoplasma gondii subtilisin SUB10 0.042 0.0405 1
Echinococcus granulosus glutamate receptor 2 0.005 0.0016 0.0016
Toxoplasma gondii subtilisin SUB2 0.042 0.0405 1
Echinococcus multilocularis Furin 1 0.2323 0.2404 0.3004
Brugia malayi hypothetical protein 0.012 0.009 0.0089
Giardia lamblia High cysteine membrane protein Group 2 0.3518 0.3659 1
Brugia malayi Integrin alpha pat-2 precursor 0.0453 0.0439 0.0439
Schistosoma mansoni protein arginine n-methyltransferase 0.0089 0.0057 0.0057
Echinococcus multilocularis fibrillin 2 0.0092 0.006 0.0075
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0051 0.0017 0.0021
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0002 0.0056
Toxoplasma gondii hypothetical protein 0.0092 0.006 0.1473
Echinococcus granulosus integrin alpha ps 0.0097 0.0066 0.0066
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0246 0.0222 0.2795
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0054 0.002 0.0076
Mycobacterium ulcerans monoamine oxidase 0.012 0.009 0.1804
Leishmania major sir2-family protein-like protein 0.0111 0.008 0.0335
Brugia malayi amine oxidase, flavin-containing family protein 0.017 0.0142 0.0142
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0017 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus multilocularis epidermal growth factor receptor 0.0625 0.062 0.0774
Brugia malayi Pepsin A precursor 0.0037 0.0002 0.0002
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0051 0.0017 0.0017
Toxoplasma gondii subtilisin SUB12 0.042 0.0405 1
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0157 0.0129 0.0129
Schistosoma mansoni amine oxidase 0.012 0.009 0.0089
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0009 0.0009
Brugia malayi angiogenesis inhibito 0.0052 0.0018 0.0018
Brugia malayi hypothetical protein 0.0037 0.0002 0.0002
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.012 0.009 0.2207
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.012 0.009 0.1867
Echinococcus granulosus MAM 0.0095 0.0063 0.0063
Trichomonas vaginalis WD repeat domain, putative 0.0205 0.0179 0.029
Echinococcus multilocularis chromatin regulatory protein sir2 0.0752 0.0753 0.0941
Giardia lamblia hypothetical protein 0.0092 0.006 0.012
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Loa Loa (eye worm) fatty acid synthase 0.0085 0.0053 0.0052
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.0023 0.0023
Mycobacterium tuberculosis Conserved hypothetical protein 0.012 0.009 0.2209
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.042 0.0405 0.0405
Schistosoma mansoni hypothetical protein 0.0205 0.0179 0.0179
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.005 0.0016 0.002
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.042 0.0405 1
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0112 0.0081 0.0081
Echinococcus granulosus chromatin regulatory protein sir2 0.0752 0.0753 0.0753
Brugia malayi hypothetical protein 0.0246 0.0222 0.0222
Schistosoma mansoni SWI/SNF complex-related 0.005 0.0016 0.0016
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1903 0.1962 0.3214
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.042 0.0405 0.0506
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0066 0.0033 0.0336
Echinococcus granulosus protein kinase c epsilon type 0.0182 0.0155 0.0155
Mycobacterium leprae Polyketide synthase Pks13 0.0125 0.0095 0.2013
Schistosoma mansoni apoptosis regulator bax 0.0056 0.0023 0.0023
Echinococcus granulosus growth factor receptor bound protein 2 0.0127 0.0097 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.042 0.0405 0.0661
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0182 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0112 0.0081 0.0081
Mycobacterium ulcerans protoporphyrinogen oxidase 0.012 0.009 0.1804
Mycobacterium ulcerans thioesterase 0.0072 0.0039 0.0485
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0089 0.0057 0.0071
Onchocerca volvulus 0.0037 0.0003 0.0038
Loa Loa (eye worm) hypothetical protein 0.0037 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Trichomonas vaginalis conserved hypothetical protein 0.042 0.0405 0.0661
Loa Loa (eye worm) subtilase 0.042 0.0405 0.0405
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0089 0.0057 0.0071
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0044 0.0009 0.0009
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0089 0.0057 0.1396
Brugia malayi transcriptional regulator, Sir2 family protein 0.0111 0.008 0.008
Giardia lamblia Neurogenic locus notch-like protein 0.0092 0.006 0.012
Onchocerca volvulus 0.0092 0.006 0.0938
Loa Loa (eye worm) hypothetical protein 0.0039 0.0005 0.0005
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0089 0.0057 0.0057
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0002 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Toxoplasma gondii subtilisin SUB7 0.042 0.0405 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0016 0.0016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0016 0.002
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0049 0.0015 0.0365
Echinococcus granulosus lysine specific histone demethylase 1A 0.059 0.0583 0.0583
Entamoeba histolytica PH domain containing protein kinase, putative 0.0149 0.012 0.1407
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0017 0.0418
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0157 0.0129 0.0207
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.042 0.0405 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.042 0.0405 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0089 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0246 0.0222 0.0222
Mycobacterium ulcerans polyketide synthase 0.0083 0.0051 0.0793
Echinococcus granulosus inhibitor of apoptosis protein 0.0112 0.0081 0.0081
Schistosoma mansoni site-1 peptidase (S08 family) 0.042 0.0405 0.0405
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0088 0.0056 0.1386
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0017 0.0021
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0017 0.0017
Schistosoma mansoni hypothetical protein 0.0089 0.0057 0.0057
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0092 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Plasmodium falciparum plasmepsin III 0.0037 0.0002 0.0056
Schistosoma mansoni hypothetical protein 0.1903 0.1962 0.1962
Mycobacterium ulcerans NAD-dependent deacetylase 0.0111 0.008 0.1558
Loa Loa (eye worm) reprolysin 0.0089 0.0057 0.0057
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0246 0.0222 0.2374
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus multilocularis 0.7653 0.8001 1
Brugia malayi hypothetical protein 0.0117 0.0086 0.0086
Brugia malayi proprotein convertase 2 0.6037 0.6305 0.6304
Plasmodium falciparum plasmepsin I 0.0037 0.0002 0.0056
Toxoplasma gondii subtilisin SUB9 0.042 0.0405 1
Schistosoma mansoni integrin alpha-ps 0.0203 0.0177 0.0177
Giardia lamblia Tenascin-37 0.0092 0.006 0.012
Onchocerca volvulus 0.0112 0.0081 0.1272
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Trichomonas vaginalis hypothetical protein 0.0092 0.006 0.0094
Loa Loa (eye worm) hypothetical protein 0.0116 0.0085 0.0085
Echinococcus multilocularis discoidin domain receptor 0.0051 0.0017 0.0021
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0002 0.0002
Echinococcus multilocularis integrin alpha ps 0.0203 0.0177 0.0221
Schistosoma mansoni hypothetical protein 0.0095 0.0063 0.0063
Onchocerca volvulus 0.0095 0.0063 0.0987
Schistosoma mansoni hypothetical protein 0.0051 0.0017 0.0017
Onchocerca volvulus 0.0095 0.0063 0.0987
Schistosoma mansoni discoidin domain receptor 0.0051 0.0017 0.0017
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0002 0.0002
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0073 0.004 0.004
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0627 0.0622 0.0622
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Echinococcus granulosus adam 17 protease 0.0037 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0092 0.006 0.006
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0016 0.0022
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0017 0.0418
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.0023 0.0028
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.042 0.0405 1
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0085 0.0052 0.1293
Plasmodium vivax aspartyl protease, putative 0.0037 0.0002 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0066 0.0033 0.0409
Giardia lamblia Sirtuin type 2 0.0111 0.008 0.0176
Echinococcus multilocularis lysine specific histone demethylase 1A 0.059 0.0583 0.0729
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0111 0.008 0.0335
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0111 0.008 0.008
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0002 0.0056
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0002 0.0003
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0111 0.008 0.0869
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0016 0.002
Brugia malayi Furin-like cysteine rich region family protein 0.0625 0.062 0.062
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.012 0.009 0.2207
Schistosoma mansoni hypothetical protein 0.0056 0.0023 0.0023
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0088 0.0056 0.1008
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.012 0.009 0.1804
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0051 0.0017 0.0024
Plasmodium vivax plasmepsin V, putative 0.0416 0.0401 0.9894
Echinococcus multilocularis fibrillin 1 0.0094 0.0062 0.0078
Onchocerca volvulus 0.064 0.0636 1
Brugia malayi SWIRM domain containing protein 0.005 0.0016 0.0016
Brugia malayi Sex muscle abnormal protein 5 0.0127 0.0097 0.0097
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0002 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1332 0.1363 0.1363
Schistosoma mansoni serine/threonine protein kinase 0.0182 0.0155 0.0155
Plasmodium vivax LCCL domain-containing protein 0.0051 0.0017 0.0418
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.9556 1 1
Leishmania major subtilisin-like serine peptidase 0.042 0.0405 0.5003
Loa Loa (eye worm) hypothetical protein 0.0095 0.0063 0.0063
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.042 0.0405 0.0405
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0056 0.1386
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Leishmania major UDP-galactopyranose mutase 0.012 0.009 0.0471
Loa Loa (eye worm) hypothetical protein 0.0044 0.001 0.0009
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0111 0.008 0.1973
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0051 0.0017 0.0024
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0089 0.0057 0.0057
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Schistosoma mansoni chromatin regulatory protein sir2 0.0752 0.0753 0.0753
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0111 0.008 0.0335
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.014 0.011 0.0138
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0002 0.0002
Echinococcus granulosus sodium:myo inositol cotransporter 0.0146 0.0116 0.0116
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Plasmodium vivax hypothetical protein, conserved 0.012 0.009 0.2207
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0083 0.0051 0.0864
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0002 0.0002
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0083 0.0051 0.0864
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0089 0.0057 0.1396
Onchocerca volvulus 0.0149 0.0121 0.1894
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5842 0.6099 0.6099
Schistosoma mansoni amine oxidase 0.012 0.009 0.0089
Echinococcus granulosus integrin alpha 3 0.0347 0.0328 0.0328
Loa Loa (eye worm) endoprotease bli-4 0.9556 1 1
Schistosoma mansoni hypothetical protein 0.0056 0.0023 0.0023
Brugia malayi EGF-like domain containing protein 0.0092 0.006 0.006
Echinococcus multilocularis integrin alpha ps 0.0203 0.0177 0.0221
Plasmodium falciparum plasmepsin VII 0.0037 0.0002 0.0056
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2323 0.2404 0.3939
Schistosoma mansoni tyrosine kinase 0.0625 0.062 0.062
Echinococcus granulosus lysine specific histone demethylase 1A 0.012 0.009 0.0089
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0111 0.008 0.008
Plasmodium vivax aspartyl protease, putative 0.0037 0.0002 0.0056
Loa Loa (eye worm) hypothetical protein 0.3714 0.3864 0.3864
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.008 0.008
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0278 0.0256 0.032
Echinococcus granulosus discoidin domain receptor 0.0051 0.0017 0.0017
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0146 0.0116 0.0145
Onchocerca volvulus 0.0051 0.0017 0.0266
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0111 0.008 0.0869
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0157 0.0129 0.0129
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0157 0.0129 0.0207
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0088 0.0056 0.0939
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0111 0.008 0.01
Toxoplasma gondii subtilisin SUB6 0.042 0.0405 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0083 0.0051 0.1248
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0067 0.0034 0.0842
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0002 0.0002
Mycobacterium ulcerans oxidoreductase 0.012 0.009 0.1804
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0246 0.0222 0.2374
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0003 0.0003
Echinococcus multilocularis membrane bound transcription factor site 1 0.042 0.0405 0.0506
Schistosoma mansoni integrin alpha-ps 0.0106 0.0075 0.0074
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.016 0.0131 0.0131
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0088 0.0056 0.0939
Onchocerca volvulus 0.0037 0.0002 0.0036
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0089 0.0057 0.0089
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0089 0.0057 0.0057
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0451 0.0437 0.5458
Echinococcus multilocularis serine:threonine protein kinase N2 0.0167 0.0138 0.0173
Loa Loa (eye worm) hypothetical protein 0.0551 0.0543 0.0542
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0003 0.0002
Schistosoma mansoni glutamate receptor NMDA 0.005 0.0016 0.0016
Schistosoma mansoni glutamate receptor NMDA 0.0278 0.0256 0.0256
Echinococcus multilocularis nmda type glutamate receptor 0.0118 0.0087 0.0109
Leishmania major silent information regulator 2, putative 0.0752 0.0753 1
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0002 0.0056
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0157 0.0129 0.3179
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0072 0.0039 0.0558
Toxoplasma gondii aspartyl protease ASP5 0.0379 0.0362 0.8934
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Plasmodium falciparum plasmepsin V 0.0416 0.0401 0.9894
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Echinococcus multilocularis adam 0.0209 0.0183 0.0228
Plasmodium falciparum plasmepsin X 0.0037 0.0002 0.0056
Loa Loa (eye worm) TK/ALK protein kinase 0.0095 0.0063 0.0063
Mycobacterium leprae Possible secreted protease 0.042 0.0405 1
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0242 0.0218 0.0218
Echinococcus granulosus serine:threonine protein kinase N2 0.0149 0.012 0.012
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0111 0.008 0.0176
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Brugia malayi EGF-like domain containing protein 0.0092 0.006 0.006
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0085 0.0052 0.5
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0752 0.0753 0.0753
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.008 0.0048 0.118
Giardia lamblia Furin precursor putative serine protease 0.1903 0.1962 0.5342
Loa Loa (eye worm) hypothetical protein 0.9556 1 1
Echinococcus granulosus neuroendocrine convertase 2 0.6037 0.6305 0.6304
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Mycobacterium ulcerans Sir2-like regulatory protein 0.0111 0.008 0.1558
Echinococcus granulosus integrin alpha ps 0.0203 0.0177 0.0177
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0125 0.0095 0.2349
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0226 0.0201 0.0201
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1903 0.1962 0.3214
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0122 0.0092 0.0091
Loa Loa (eye worm) transcriptional regulator 0.0111 0.008 0.008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Loa Loa (eye worm) hypothetical protein 0.0056 0.0023 0.0023
Toxoplasma gondii subtilisin SUB11 0.042 0.0405 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0752 0.0753 0.0753
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0002 0.0056
Toxoplasma gondii subtilisin SUB8 0.042 0.0405 1
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0088 0.0056 0.1386
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.042 0.0405 0.0405
Brugia malayi ADAM-TS Spacer 1 family protein 0.0052 0.0018 0.0018
Brugia malayi Stress-activated protein kinase jnk-1 0.0226 0.0201 0.0201
Onchocerca volvulus Fatty acid synthase homolog 0.0155 0.0126 0.1982
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0706 0.0705 0.0881
Echinococcus granulosus protein arginine N methyltransferase 7 0.0089 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0062 0.0028 0.0699
Toxoplasma gondii SWIRM domain-containing protein 0.005 0.0016 0.0391
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.042 0.0405 0.5003
Echinococcus granulosus sodium:glucose cotransporter 2 0.0146 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.017 0.0142 0.0142
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Brugia malayi Angiotensin-converting enzyme family protein 0.0627 0.0622 0.0622
Trichomonas vaginalis hypothetical protein 0.0051 0.0017 0.0024
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0057 0.0057
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0016 0.0016
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0051 0.1248
Loa Loa (eye worm) hypothetical protein 0.064 0.0636 0.0636
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0051 0.0017 0.0021
Plasmodium vivax NAD-dependent deacetylase, putative 0.0111 0.008 0.1973
Entamoeba histolytica hypothetical protein, conserved 0.0111 0.008 0.0869
Brugia malayi GH02984p 0.0037 0.0003 0.0002
Echinococcus multilocularis neuroendocrine convertase 2 0.6037 0.6305 0.7879
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.014 0.011 0.011
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0002 0.0056
Schistosoma mansoni inositol transporter 0.0146 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.0089 0.0057 0.0057
Trypanosoma cruzi UDP-galactopyranose mutase 0.012 0.009 0.0471
Loa Loa (eye worm) hypothetical protein 0.025 0.0226 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.042 0.0405 1
Trichomonas vaginalis conserved hypothetical protein 0.042 0.0405 0.0661
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0112 0.0081 0.0081
Toxoplasma gondii aspartyl protease 0.0037 0.0002 0.0056
Loa Loa (eye worm) acyl carrier protein 0.0039 0.0005 0.0005
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0117 0.0086 0.0086
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0111 0.008 0.01
Echinococcus multilocularis high affinity choline transporter 1 0.0037 0.0003 0.0003
Brugia malayi Kelch motif family protein 0.0581 0.0574 0.0574
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0706 0.0705 0.0705
Echinococcus granulosus Furin 1 0.2323 0.2404 0.2404
Echinococcus granulosus sodium:glucose cotransporter 0.0146 0.0116 0.0116
Trichomonas vaginalis conserved hypothetical protein 0.042 0.0405 0.0661
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0088 0.0056 0.1008
Trypanosoma brucei SIR2-like protein 4, putative 0.0111 0.008 0.0335
Schistosoma mansoni integrin beta subunit 0.2111 0.2181 0.2181
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0085 0.0052 0.0841
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0112 0.0081 0.0081
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0752 0.0753 1
Loa Loa (eye worm) proprotein convertase 2 0.2323 0.2404 0.2404
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0051 0.0793
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Plasmodium falciparum plasmepsin II 0.0037 0.0002 0.0056
Onchocerca volvulus Putative cubilin 0.0039 0.0005 0.0072
Plasmodium vivax subtilisin-like protease 2, putative 0.042 0.0405 1
Echinococcus granulosus fibrillin 1 0.0094 0.0062 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Plasmodium falciparum plasmepsin IX 0.0037 0.0002 0.0056
Toxoplasma gondii histone deacetylase SIR2 0.0111 0.008 0.1973
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Echinococcus granulosus membrane bound transcription factor site 1 0.042 0.0405 0.0405
Loa Loa (eye worm) hypothetical protein 0.0112 0.0081 0.0081
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0083 0.0051 0.1258
Loa Loa (eye worm) integrin alpha pat-2 0.0698 0.0697 0.0696
Plasmodium vivax subtilisin-like protease 1 0.042 0.0405 1
Schistosoma mansoni inositol transporter 0.0146 0.0116 0.0116
Trichomonas vaginalis hypothetical protein 0.1903 0.1962 0.3214
Schistosoma mansoni serine/threonine protein kinase 0.0226 0.0201 0.0201
Toxoplasma gondii histone deacetylase SIR2-like 0.0111 0.008 0.1973
Schistosoma mansoni protein kinase 0.014 0.011 0.011
Schistosoma mansoni chromatin regulatory protein sir2 0.0752 0.0753 0.0753
Schistosoma mansoni hypothetical protein 0.0097 0.0066 0.0066
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2323 0.2404 0.3939
Loa Loa (eye worm) hypothetical protein 0.059 0.0583 0.0583
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0157 0.0129 0.0161
Onchocerca volvulus 0.042 0.0405 0.637
Plasmodium falciparum subtilisin-like protease 3 0.042 0.0405 1
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0111 0.008 0.1973
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0122 0.0092 0.0091
Brugia malayi AMP-binding enzyme family protein 0.008 0.0048 0.0048
Schistosoma mansoni growth factor receptor-bound protein 0.0127 0.0097 0.0097
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0752 0.0753 1
Schistosoma mansoni septate junction protein 0.006 0.0027 0.0026
Plasmodium vivax hypothetical protein, conserved 0.012 0.009 0.2207
Loa Loa (eye worm) hypothetical protein 0.0342 0.0323 0.0323
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0016 0.0022
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0017 0.0021
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.0017 0.0418
Loa Loa (eye worm) hypothetical protein 0.012 0.009 0.0089
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0342 0.0323 0.0323
Echinococcus multilocularis solute carrier family 5 0.0146 0.0116 0.0145
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0752 0.0753 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0083 0.0051 0.1248
Echinococcus multilocularis protein arginine methyltransferase 0.0157 0.0129 0.0161
Schistosoma mansoni growth factor receptor-bound protein 0.0127 0.0097 0.0097
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0112 0.0081 0.0081
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0089 0.0057 0.0057
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0002 0.0056
Loa Loa (eye worm) hypothetical protein 0.0111 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0002 0.0002
Plasmodium vivax LCCL domain-containing protein 0.0051 0.0017 0.0418
Brugia malayi Protein kinase domain containing protein 0.0095 0.0063 0.0063
Plasmodium falciparum protoporphyrinogen oxidase 0.012 0.009 0.2207
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.042 0.0405 1
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0085 0.0052 0.5
Echinococcus granulosus glutamate NMDA receptor subunit 0.0278 0.0256 0.0256
Schistosoma mansoni btb and poz domain-containing protein 0.0051 0.0017 0.0017
Loa Loa (eye worm) Carm1-pending protein 0.0089 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Brugia malayi Disintegrin family protein 0.0037 0.0002 0.0002
Giardia lamblia High cysteine protein 0.0092 0.006 0.012
Onchocerca volvulus Deterin homolog 0.0112 0.0081 0.1272
Loa Loa (eye worm) integrin beta-2 0.3603 0.3748 0.3748
Echinococcus granulosus epidermal growth factor receptor 0.0625 0.062 0.062
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.0023 0.0023
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Plasmodium falciparum subtilisin-like protease 2 0.042 0.0405 1
Schistosoma mansoni hypothetical protein 0.0056 0.0023 0.0023
Brugia malayi Will die slowly protein 0.0205 0.0179 0.0179
Plasmodium falciparum LCCL domain-containing protein 0.0051 0.0017 0.0418
Plasmodium vivax protoporphyrinogen oxidase, putative 0.012 0.009 0.2207
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Loa Loa (eye worm) WD40 repeat protein 0.0205 0.0179 0.0179
Echinococcus granulosus high affinity choline transporter 1 0.0037 0.0003 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Echinococcus multilocularis discoidin domain containing receptor 2 0.0051 0.0017 0.0021
Echinococcus granulosus protein arginine N methyltransferase 8 0.0157 0.0129 0.0129
Toxoplasma gondii subtilisin SUB1 0.042 0.0405 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0127 0.0097 0.0097
Loa Loa (eye worm) transcriptional regulator 0.0111 0.008 0.008
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.042 0.0405 0.0405
Mycobacterium ulcerans polyketide synthase Pks13 0.0125 0.0095 0.1952
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0752 0.0753 1
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.012 0.009 0.0089
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2323 0.2404 0.3939
Brugia malayi SWIRM domain containing protein 0.064 0.0636 0.0636
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.005 0.0016 0.002
Entamoeba histolytica hypothetical protein 0.0246 0.0222 0.2795
Schistosoma mansoni sodium/solute symporter 0.0037 0.0003 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2323 0.2404 0.3939
Onchocerca volvulus 0.0051 0.0017 0.0266
Giardia lamblia Transcriptional regulator, Sir2 family 0.0111 0.008 0.0176
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.042 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.042 0.0405 0.0405
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0089 0.0057 0.0072
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0002 0.0002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0002 0.0002
Trypanosoma cruzi subtilisin peptidase 0.042 0.0405 0.5003
Onchocerca volvulus 0.008 0.0048 0.075
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0157 0.0129 0.0129
Loa Loa (eye worm) hypothetical protein 0.0095 0.0063 0.0063
Echinococcus granulosus integrin beta 2 0.2662 0.276 0.276
Plasmodium falciparum subtilisin-like protease 1 0.042 0.0405 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0111 0.008 0.008
Toxoplasma gondii PA14 domain-containing protein 0.0051 0.0017 0.0418
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0111 0.008 0.01
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Brugia malayi Reprolysin 0.0052 0.0018 0.0018
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0002 0.0002
Echinococcus multilocularis glutamate receptor 2 0.005 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0355 0.0337 0.0337
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.012 0.009 0.2207
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0226 0.0201 0.0251
Schistosoma mansoni protein kinase 0.014 0.011 0.011
Mycobacterium leprae Probable polyketide synthase Pks1 0.0088 0.0056 0.1008
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0083 0.0051 0.0793
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.005 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0051 0.0017 0.0017
Echinococcus granulosus furin 0.9556 1 1
Trypanosoma brucei subtilisin peptidase 0.042 0.0405 0.5003
Echinococcus multilocularis protoporphyrinogen oxidase 0.012 0.009 0.0112
Brugia malayi Integrin beta pat-3 precursor 0.3603 0.3748 0.3748
Mycobacterium ulcerans thioesterase TesA 0.0072 0.0039 0.0485
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.0023 0.0023
Schistosoma mansoni high-affinity choline transporter 0.0037 0.0003 0.0002
Plasmodium vivax aspartyl protease, putative 0.0037 0.0002 0.0056
Leishmania major arginine N-methyltransferase-like protein 0.0157 0.0129 0.1037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0003 0.0002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Brugia malayi GCC2 and GCC3 family protein 0.0044 0.001 0.0009
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0002 0.0002
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1903 0.1962 0.3214
Schistosoma mansoni Lysine-specific histone demethylase 1 0.059 0.0583 0.0583
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0111 0.008 0.0127
Echinococcus granulosus discoidin domain containing receptor 2 0.0051 0.0017 0.0017
Onchocerca volvulus 0.0171 0.0143 0.2254
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.012 0.009 0.1804
Schistosoma mansoni discoidin domain receptor 0.0051 0.0017 0.0017
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0002 0.0056
Echinococcus multilocularis protein jagged 2 0.0092 0.006 0.0075
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0451 0.0437 0.5458
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0111 0.008 0.1973
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Echinococcus multilocularis integrin alpha ps 0.0097 0.0066 0.0082
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Mycobacterium tuberculosis Possible oxidoreductase 0.012 0.009 0.2209
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.0023 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.1903 0.1962 0.3214
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5842 0.6099 1
Brugia malayi hypothetical protein 0.0095 0.0063 0.0063
Echinococcus multilocularis protein kinase c epsilon type 0.0182 0.0155 0.0193
Echinococcus multilocularis 0.012 0.009 0.0112
Loa Loa (eye worm) hypothetical protein 0.0092 0.006 0.006
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0066 0.0033 0.0336
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0005 0.0005
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.005 0.0016 0.0016
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.042 0.0405 0.0405
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0056 0.0022 0.0541
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0146 0.0116 0.0145
Loa Loa (eye worm) hypothetical protein 0.0052 0.0018 0.0018
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2323 0.2404 0.3939
Brugia malayi protein kinase C II. 0.0182 0.0155 0.0155
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0157 0.0129 0.3179
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0028 0.0682
Brugia malayi hypothetical protein 0.0037 0.0002 0.0002
Giardia lamblia High cysteine protein 0.0092 0.006 0.012
Brugia malayi transcriptional regulator, Sir2 family protein 0.0752 0.0753 0.0753
Echinococcus multilocularis inhibitor of apoptosis protein 0.0112 0.0081 0.0101
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0112 0.0081 0.0101
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.042 0.0405 1
Loa Loa (eye worm) hypothetical protein 0.0095 0.0063 0.0063
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0752 0.0753 0.0941
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0043 0.0009 0.0222
Brugia malayi EGF-like domain containing protein 0.0092 0.006 0.006
Loa Loa (eye worm) hypothetical protein 0.0141 0.0112 0.0112
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0451 0.0437 0.5458
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0002 0.0002
Loa Loa (eye worm) TK/EGFR protein kinase 0.0625 0.062 0.062
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0111 0.008 0.1975
Loa Loa (eye worm) hypothetical protein 0.0051 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0106 0.0075 0.0074
Loa Loa (eye worm) sirtuin 4 0.0111 0.008 0.008
Brugia malayi EGF-like domain containing protein 0.0092 0.006 0.006
Onchocerca volvulus 0.0205 0.0179 0.2812
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0003 0.0059
Toxoplasma gondii subtilisin SUB5 0.042 0.0405 1
Schistosoma mansoni dock 0.0051 0.0017 0.0017
Brugia malayi celfurPC protein 0.7653 0.8001 0.8001
Echinococcus granulosus protein arginine methyltransferase 0.0157 0.0129 0.0129
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0051 0.0793
Brugia malayi NAD-dependent deacetylase SIRT1 0.0111 0.008 0.008
Echinococcus granulosus solute carrier family 5 0.0146 0.0116 0.0116
Loa Loa (eye worm) hypothetical protein 0.059 0.0583 0.0583
Mycobacterium ulcerans Type I modular polyketide synthase 0.0083 0.0051 0.0793
Echinococcus granulosus c-Jun N-terminal kinases 0.0226 0.0201 0.0201
Schistosoma mansoni integrin alpha 0.0453 0.0439 0.0439
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2323 0.2404 0.3939
Plasmodium falciparum plasmepsin IV 0.0037 0.0002 0.0056
Toxoplasma gondii histone lysine-specific demethylase 0.012 0.009 0.2207
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2323 0.2404 0.2404
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0002 0.0056
Toxoplasma gondii F5/8 type C domain-containing protein 0.0051 0.0017 0.0418
Plasmodium falciparum plasmepsin VI 0.0037 0.0002 0.0056
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0581 0.0574 0.0574
Toxoplasma gondii subtilisin SUB4 0.042 0.0405 1
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0089 0.0057 0.0089
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0118 0.0087 0.0109
Giardia lamblia Tenascin precursor 0.0092 0.006 0.012
Brugia malayi hypothetical protein 0.0551 0.0543 0.0542
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.042 0.0405 1
Brugia malayi Protein kinase domain containing protein 0.0051 0.0017 0.0017
Toxoplasma gondii type I fatty acid synthase, putative 0.0088 0.0056 0.1384
Brugia malayi Carm1-pending protein 0.0089 0.0057 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.042 0.0405 0.0661
Echinococcus granulosus adam 0.0209 0.0183 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Echinococcus granulosus methyltransferase protein 5 0.0089 0.0057 0.0057
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0752 0.0753 0.1231
Echinococcus granulosus nmda type glutamate receptor 0.0118 0.0087 0.0087
Chlamydia trachomatis protoporphyrinogen oxidase 0.012 0.009 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0017 0.0024
Loa Loa (eye worm) transcriptional regulator 0.0752 0.0753 0.0753
Echinococcus multilocularis protein will die slowly 0.0205 0.0179 0.0223
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.042 0.0405 0.0661
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0111 0.008 0.0335
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0083 0.0051 0.005
Echinococcus multilocularis MAM 0.0095 0.0063 0.0078
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0111 0.008 0.0335
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0003 0.0002

Activities

Activity type Activity value Assay description Source Reference
Analgesic activity (functional) = 62 Analgesic activity in male albino Swiss-Webster mice in hot-plate test ChEMBL. 8201606
ED50 (functional) = 26 mg kg-1 Analgesic potency of the compound was evaluated as effective dose after subcutaneous administration. ChEMBL. 8201606
ED50 (functional) = 26 mg kg-1 Analgesic potency of the compound was evaluated as effective dose after subcutaneous administration. ChEMBL. 8201606

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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