Detailed information for compound 823682

Basic information

Technical information
  • TDR Targets ID: 823682
  • Name: N-(4-ethylphenyl)-2-(8-methyl-4-oxochromeno[3 ,4-d]pyrazol-1-yl)-N-propylacetamide
  • MW: 403.474 | Formula: C24H25N3O3
  • H donors: 0 H acceptors: 3 LogP: 4.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)Cn1ncc2c1c1cc(C)ccc1oc2=O)c1ccc(cc1)CC
  • InChi: 1S/C24H25N3O3/c1-4-12-26(18-9-7-17(5-2)8-10-18)22(28)15-27-23-19-13-16(3)6-11-21(19)30-24(29)20(23)14-25-27/h6-11,13-14H,4-5,12,15H2,1-3H3
  • InChiKey: LVVBMHLMHUNUPY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethylphenyl)-2-(8-methyl-4-oxo-chromeno[3,4-d]pyrazol-1-yl)-N-propyl-acetamide
  • N-(4-ethylphenyl)-2-(8-methyl-4-oxo-1-chromeno[3,4-d]pyrazolyl)-N-propylacetamide
  • N-(4-ethylphenyl)-2-(4-keto-8-methyl-chromeno[3,4-d]pyrazol-1-yl)-N-propyl-acetamide
  • N-(4-ethylphenyl)-2-(8-methyl-4-oxo-chromeno[3,4-d]pyrazol-1-yl)-N-propyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0037 0.0741
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0037 0.001
Brugia malayi Retinol dehydrogenase 12 0.0042 0.0144 0.0144
Brugia malayi nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0037 0.0037
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Echinococcus granulosus hypothetical protein 0.0042 0.0144 0.0144
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0006 0.0006
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi Cytochrome P450 family protein 0.0023 0.0062 0.0062
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0058 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0075 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0012 0.0012
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0037 0.0037
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Echinococcus multilocularis oxidoreductase 0.0042 0.0144 0.0144
Echinococcus multilocularis pyruvate kinase 0.0036 0.0122 0.0122
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0042 0.0144 1
Leishmania major short chain dehydrogenase-like protein 0.0042 0.0144 0.0139
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0075
Brugia malayi Cytochrome P450 family protein 0.0023 0.0062 0.0062
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0122 0.7917
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Brugia malayi hypothetical protein 0.0134 0.0552 0.0552
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0042 0.0144 1
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0042 0.0144 0.0137
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0042 0.0144 0.0144
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.0007
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0122 0.0112
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0248 0.0248
Brugia malayi hypothetical protein 0.0042 0.0144 0.0144
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.0007
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0122 0.0112
Echinococcus granulosus vesicular acetylcholine transporter 0.2274 1 1
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0007 0.0007
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0042 0.0144 1
Mycobacterium ulcerans ketoacyl reductase 0.0042 0.0144 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0075 0.4043
Brugia malayi hypothetical protein 0.0042 0.0144 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0075 0.4043
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0058 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0075 0.4043
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0122 0.8071
Onchocerca volvulus 0.0042 0.0144 0.0137
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0007 0.0007
Giardia lamblia Pyruvate kinase 0.0036 0.0122 0.7785
Brugia malayi ecdysone receptor 0.001 0.0007 0.0007
Echinococcus granulosus hypothetical protein 0.0042 0.0144 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Echinococcus granulosus retinol dehydrogenase 11 0.0042 0.0144 0.0144
Echinococcus multilocularis steroid dehydrogenase 0.0042 0.0144 0.0144
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0058 0.0052
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0042 0.0144 0.0144
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0007 0.0007
Mycobacterium ulcerans oxidoreductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0552 0.0552
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0058 0.0058
Onchocerca volvulus 0.0042 0.0144 0.0137
Plasmodium vivax steroid dehydrogenase, putative 0.0042 0.0144 1
Giardia lamblia Short-chain dehydrogenase, putative 0.0042 0.0144 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0037 0.0741
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0042 0.0144 1
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2274 1 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0062 0.0062
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0007
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0058 0.0058
Trichomonas vaginalis steroid dehydrogenase, putative 0.0042 0.0144 1
Brugia malayi Cytochrome P450 family protein 0.0065 0.0248 0.0248
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0007 0.0007
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0537 0.0537
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0042 0.0144 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0042 0.0144 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0122 0.3881
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0042 0.0144 1
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0043 0.0596
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 0.0139
Leishmania major short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Onchocerca volvulus 0.0042 0.0144 0.0137
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0042 0.0144 1
Echinococcus granulosus GPCR family 2 0.0017 0.0037 0.0037
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0075 0.0302
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0042 0.0144 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0118 0.0118
Brugia malayi oxidoreductase 0.0042 0.0144 0.0144
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0058 0.0058
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0007
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0037 0.001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Onchocerca volvulus 0.0042 0.0144 0.0137
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0006 0.0006
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Echinococcus granulosus retinol dehydrogenase 11 0.0042 0.0144 0.0144
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Echinococcus granulosus WW domain containing oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0042 0.0144 1
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Echinococcus multilocularis 0.0015 0.0028 0.0028
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0144
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0122 0.0112
Brugia malayi steroid hormone receptor 0.0022 0.0058 0.0058
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0075 0.0302
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0042 0.0144 1
Echinococcus multilocularis retinol dehydrogenase 11 0.0042 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0058
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) DR-78 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.1898 0.834 0.834
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0058
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0201 0.0201
Onchocerca volvulus 0.0042 0.0144 0.0137
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0037 0.001
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0042 0.0144 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Brugia malayi MH2 domain containing protein 0.0131 0.0537 0.0537
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis GPCR, family 2 0.0017 0.0037 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Leishmania major dehydrogenase-like protein 0.0042 0.0144 0.0139
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0046 0.0864
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0006 0.0006
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0007 0.0007
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0122 0.3881
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0037 0.0741
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0037 0.0037
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) STAT protein 0.0173 0.0723 0.0723
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0062 0.004
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0042 0.0144 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Mycobacterium ulcerans dehydrogenase/reductase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Brugia malayi hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0037 0.0037
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0007 0.0007
Brugia malayi dehydrogenases, short chain protein 2 0.0042 0.0144 0.0144
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0062 0.2899
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0007 0.0007
Echinococcus granulosus pyruvate kinase 0.0036 0.0122 0.0122
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0058
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0007 0.0007
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0043 0.1293
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0075 0.4043
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0058
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0042 0.0144 1
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0012 0.0012
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0122 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0125 0.0125
Brugia malayi conserved hypotetical protein 0.001 0.0007 0.0007
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0118 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0042 0.0144 0.0144
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0042 0.0144 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0058 0.0058
Schistosoma mansoni retinal dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0144 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0075 0.4043
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0075 0.4043
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0058 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0075 0.0075
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0073 0.0073
Mycobacterium ulcerans short-chain type oxidoreductase 0.0042 0.0144 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0075 0.4043
Brugia malayi nuclear receptor RXR 0.0012 0.0012 0.0012
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0062 0.004
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0075
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0042 0.0144 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0037 0.0037
Giardia lamblia Hypothetical protein 0.0042 0.0144 1
Brugia malayi nuclear receptor RXR 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0042 0.0144 1
Schistosoma mansoni pyruvate kinase 0.0019 0.0043 0.0043
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0118 0.0118
Leishmania major 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Entamoeba histolytica short chain dehydrogenase family protein 0.0042 0.0144 1
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0042 0.0144 0.0144
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0028 0.0028
Plasmodium falciparum steroid dehydrogenase, putative 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis steroid dehydrogenase 0.0042 0.0144 0.0144
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0058 0.0058
Schistosoma mansoni vesicular acetylcholine transporter 0.2274 1 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0042 0.0144 0.0144
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Schistosoma mansoni zinc finger protein 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0058
Echinococcus multilocularis retinol dehydrogenase 13 0.0042 0.0144 0.0144
Trypanosoma cruzi short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Toxoplasma gondii oxidoreductase, putative 0.0042 0.0144 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0037 0.0037
Echinococcus multilocularis retinol dehydrogenase 11 0.0042 0.0144 0.0144
Onchocerca volvulus Huntingtin homolog 0.0134 0.0552 0.0546
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0058
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.0043
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0037 0.0037
Chlamydia trachomatis pyruvate kinase 0.0036 0.0122 1
Leishmania major pyruvate kinase 0.0036 0.0122 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0042 0.0144 0.0139
Brugia malayi STAT protein, DNA binding domain containing protein 0.0173 0.0723 0.0723
Mycobacterium ulcerans dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni hypothetical protein 0.0015 0.0028 0.0028
Mycobacterium ulcerans ketoacyl reductase 0.0042 0.0144 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0042 0.0144 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0058 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0144 1
Onchocerca volvulus 0.0042 0.0144 0.0137
Leishmania major pteridine reductase 1 0.0042 0.0144 0.0139
Echinococcus multilocularis pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi dehydrogenases, short chain protein 9 0.0042 0.0144 0.0144
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0058 0.0058
Brugia malayi nuclear receptor NHR-67 0.001 0.0007 0.0007
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0132 0.0132
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0043
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0042 0.0144 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Leishmania major oxidoreductase-like protein 0.0042 0.0144 0.0139
Schistosoma mansoni pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0058
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0058
Onchocerca volvulus Huntingtin homolog 0.0134 0.0552 0.0546
Loa Loa (eye worm) hypothetical protein 0.0134 0.0552 0.0552
Mycobacterium ulcerans oxidoreductase 0.0042 0.0144 1
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0042 0.0144 0.0144
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0122
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0007 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0118 0.0118
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0042 0.0144 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0058 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0075 0.0075
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0042 0.0144 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0058
Onchocerca volvulus 0.0022 0.0058 0.0052
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans ketoacyl reductase 0.0042 0.0144 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0075 0.4043
Loa Loa (eye worm) hypothetical protein 0.028 0.1198 0.1198
Schistosoma mansoni carbonyl reductase 0.0042 0.0144 0.0144
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0009 0.0009
Brugia malayi nuclear receptor NHR-88 0.0022 0.0058 0.0058
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0037 0.0037
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0201 0.0201
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0058
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Echinococcus granulosus oxidoreductase 0.0042 0.0144 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.0043
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0075 0.0075
Leishmania major short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Onchocerca volvulus 0.0042 0.0144 0.0137
Loa Loa (eye worm) dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0097
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0055 0.0201 0.0201
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0042 0.0144 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0006 0.0006
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0122 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Toxoplasma gondii carbonyl reductase 1, putative 0.0042 0.0144 1
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0042 0.0144 0.0139
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.0043
Brugia malayi nuclear hormone receptor 0.001 0.0007 0.0007
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0042 0.0144 0.0144
Onchocerca volvulus 0.0042 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Trypanosoma cruzi short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0122 0.8071
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni carbonyl reductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0037
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0037 0.001
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0062 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0042 0.0144 0.5
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Onchocerca volvulus 0.0042 0.0144 0.0137
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0144 0.0144
Echinococcus multilocularis conserved hypothetical protein 0.0042 0.0144 0.0144
Brugia malayi nuclear receptor NHR-88 0.001 0.0007 0.0007
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0007 0.0007
Schistosoma mansoni carbonyl reductase 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0042 0.0144 0.0139
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0058
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0075 0.0056
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0042 0.0144 1
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Echinococcus granulosus voltage gated potassium channel 0.001 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0075
Brugia malayi Cytochrome P450 family protein 0.0015 0.0028 0.0028
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0062 0.004
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0144 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0062 0.0062
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0012 0.0012
Leishmania major short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0043
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi isocitrate dehydrogenase 0.0017 0.0037 0.0037
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0122 0.0122
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium leprae Probable oxidoreductase 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0058
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0122 0.0115
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0122 0.0122
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus multilocularis vesicular acetylcholine transporter 0.2274 1 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Onchocerca volvulus 0.0049 0.0178 0.0171
Onchocerca volvulus 0.0042 0.0144 0.0137
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1898 0.834 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0075 0.4043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0058 0.0058
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0042 0.0144 0.0144
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1898 0.834 0.834
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0046 0.0864
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0042 0.0144 1
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi Dehydrogenases, short chain protein 30 0.0042 0.0144 0.0144
Schistosoma mansoni cytochrome P450 0.0015 0.0028 0.0028
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0046 0.154
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.097 0.4244 0.4244
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0046 0.154
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0144 1
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0042 0.0144 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0075 0.0056
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0075 0.4043
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0122 0.0115
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0007 0.0007
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0537 0.0537
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Brugia malayi tailless protein 0.001 0.0007 0.0007
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0058
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0042 0.0144 0.0137
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0006 0.0006
Schistosoma mansoni coup transcription factor 0.0022 0.0058 0.0058
Loa Loa (eye worm) dehydrogenase 0.0042 0.0144 0.0144
Leishmania major pyruvate kinase 0.0036 0.0122 0.0112
Plasmodium falciparum pyruvate kinase 0.0036 0.0122 0.7917
Brugia malayi hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni hypothetical protein 0.0037 0.0125 0.0125
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0042 0.0144 1
Loa Loa (eye worm) cytochrome P450 0.0015 0.0028 0.0028
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0037 0.001
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0042 0.0144 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0042 0.0144 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi ecdysteroid receptor 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0042 0.0144 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0144 1
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2274 1 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0075 0.4043
Trypanosoma brucei oxidoreductase-like protein 0.0042 0.0144 0.0139
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0042 0.0144 0.0144
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0007 0.0007
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0058
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0006 0.0006
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0037 0.0037
Entamoeba histolytica hypothetical protein 0.0042 0.0144 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Leishmania major short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Onchocerca volvulus Sepiapterin reductase homolog 0.0042 0.0144 0.0137
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0122 0.0112
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trypanosoma brucei C-8 sterol isomerase, putative 0.1898 0.834 1
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0122 0.8071
Brugia malayi cytochrome P450 0.0015 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0042 0.0144 0.0139
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0043 0.0596
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0058 0.0052
Echinococcus granulosus steroid dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0201 0.0201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0058
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0075 0.0302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Toxoplasma gondii oxidoreductase, putative 0.0042 0.0144 1
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0088 0.0088
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0042 0.0144 0.0144
Onchocerca volvulus 0.0042 0.0144 0.0137
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0042 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0037 0.0037
Mycobacterium ulcerans hypothetical protein 0.0026 0.0075 0.4043
Schistosoma mansoni pyruvate kinase 0.0036 0.0122 0.0122
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0058 0.0052
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0042 0.0144 1
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0058 0.0058
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi photoreceptor-specific nuclear receptor 0.028 0.1198 0.1198
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0037 0.0037
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0006
Onchocerca volvulus 0.0026 0.0075 0.0069
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0042 0.0144 0.0144
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0122 0.8071
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0042 0.0144 0.0144
Giardia lamblia Reductase, putative 0.0042 0.0144 1
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0007 0.0007
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0043
Leishmania major cytochrome p450-like protein 0.0023 0.0062 0.004
Onchocerca volvulus 0.0042 0.0144 0.0137
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0042 0.0144 0.0139
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans carveol-like dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Leishmania major C-8 sterol isomerase-like protein 0.1898 0.834 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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