Detailed information for compound 823765

Basic information

Technical information
  • TDR Targets ID: 823765
  • Name: 2-(8-methyl-4-oxochromeno[3,4-d]pyrazol-1-yl) -N-(4-propan-2-ylphenyl)-N-propylacetamide
  • MW: 417.5 | Formula: C25H27N3O3
  • H donors: 0 H acceptors: 3 LogP: 4.95 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCN(C(=O)Cn1ncc2c1c1cc(C)ccc1oc2=O)c1ccc(cc1)C(C)C
  • InChi: 1S/C25H27N3O3/c1-5-12-27(19-9-7-18(8-10-19)16(2)3)23(29)15-28-24-20-13-17(4)6-11-22(20)31-25(30)21(24)14-26-28/h6-11,13-14,16H,5,12,15H2,1-4H3
  • InChiKey: KWTQHGKNNJBKNV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-isopropylphenyl)-2-(8-methyl-4-oxo-chromeno[3,4-d]pyrazol-1-yl)-N-propyl-acetamide
  • N-(4-isopropylphenyl)-2-(8-methyl-4-oxo-1-chromeno[3,4-d]pyrazolyl)-N-propylacetamide
  • N-(4-isopropylphenyl)-2-(4-keto-8-methyl-chromeno[3,4-d]pyrazol-1-yl)-N-propyl-acetamide
  • 2-(8-methyl-4-oxo-chromeno[3,4-d]pyrazol-1-yl)-N-(4-propan-2-ylphenyl)-N-propyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0075 0.0075
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.0043
Onchocerca volvulus 0.0042 0.0144 0.0137
Leishmania major short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0201 0.0201
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0037 0.0037
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Onchocerca volvulus 0.0022 0.0058 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Brugia malayi nuclear receptor NHR-88 0.0022 0.0058 0.0058
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0075 0.4043
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0011 0.0009 0.0009
Schistosoma mansoni carbonyl reductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.028 0.1198 0.1198
Mycobacterium ulcerans ketoacyl reductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0042 0.0144 1
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0058 0.0058
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0118 0.0118
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0042 0.0144 1
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0134 0.0552 0.0552
Onchocerca volvulus Huntingtin homolog 0.0134 0.0552 0.0546
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0058
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0042 0.0144 0.0144
Mycobacterium ulcerans oxidoreductase 0.0042 0.0144 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.001 0.0007 0.0007
Brugia malayi Pyruvate kinase, muscle isozyme 0.0036 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0036 0.0122 0.0122
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0043
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0132 0.0132
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0042 0.0144 1
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Leishmania major oxidoreductase-like protein 0.0042 0.0144 0.0139
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0058
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni pyruvate kinase 0.0036 0.0122 0.0122
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Brugia malayi nuclear receptor NHR-67 0.001 0.0007 0.0007
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0058 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0058 0.0058
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Onchocerca volvulus 0.0042 0.0144 0.0137
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0144 1
Echinococcus multilocularis pyruvate kinase 0.0036 0.0122 0.0122
Leishmania major pteridine reductase 1 0.0042 0.0144 0.0139
Brugia malayi dehydrogenases, short chain protein 9 0.0042 0.0144 0.0144
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Mycobacterium tuberculosis Possible oxidoreductase 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0058 0.0058
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Mycobacterium leprae Probable oxidoreductase 0.0042 0.0144 1
Brugia malayi isocitrate dehydrogenase 0.0017 0.0037 0.0037
Brugia malayi Pyruvate kinase, M2 isozyme 0.0036 0.0122 0.0122
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0122 0.0115
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Echinococcus multilocularis vesicular acetylcholine transporter 0.2274 1 1
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0058 0.0058
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0122 0.0122
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0062 0.0062
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Leishmania major short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0012 0.0012 0.0012
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0043
Brugia malayi Cytochrome P450 family protein 0.0015 0.0028 0.0028
Trypanosoma brucei cytochrome P450, putative 0.0023 0.0062 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0075
Echinococcus multilocularis transient receptor potential cation channel 0.0042 0.0144 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0042 0.0144 0.0139
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0075 0.0056
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0058
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Echinococcus granulosus voltage gated potassium channel 0.001 0.0006 0.0006
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0058
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0042 0.0144 0.5
Brugia malayi nuclear receptor NHR-88 0.001 0.0007 0.0007
Onchocerca volvulus 0.0042 0.0144 0.0137
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0042 0.0144 0.0144
Echinococcus multilocularis conserved hypothetical protein 0.0042 0.0144 0.0144
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.001 0.0007 0.0007
Schistosoma mansoni nuclear hormone receptor 0.001 0.0007 0.0007
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Schistosoma mansoni carbonyl reductase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0036 0.0122 0.8071
Trypanosoma cruzi short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Onchocerca volvulus 0.0042 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0042 0.0144 0.0144
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0037 0.001
Schistosoma mansoni carbonyl reductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0017 0.0037 0.0037
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0062 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0122 0.0115
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Toxoplasma gondii carbonyl reductase 1, putative 0.0042 0.0144 1
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0042 0.0144 0.0144
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Brugia malayi nuclear hormone receptor 0.001 0.0007 0.0007
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0055 0.0201 0.0201
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0031 0.0097 0.0097
Loa Loa (eye worm) dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0058
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0042 0.0144 0.0144
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0006 0.0006
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Entamoeba histolytica hypothetical protein 0.0042 0.0144 1
Leishmania major short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Trypanosoma brucei pyruvate kinase 1 0.0036 0.0122 0.0112
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Onchocerca volvulus Sepiapterin reductase homolog 0.0042 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Brugia malayi ecdysteroid receptor 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0042 0.0144 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2274 1 1
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0144 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Loa Loa (eye worm) nuclear receptor nhr-7B 0.001 0.0007 0.0007
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0042 0.0144 0.0144
Trypanosoma brucei oxidoreductase-like protein 0.0042 0.0144 0.0139
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0075 0.4043
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0037 0.0037
Schistosoma mansoni voltage-gated potassium channel 0.001 0.0006 0.0006
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0058
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0042 0.0144 1
Loa Loa (eye worm) cytochrome P450 0.0015 0.0028 0.0028
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0042 0.0144 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0037 0.001
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Entamoeba histolytica short chain dehydrogenase family protein 0.0042 0.0144 1
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus multilocularis voltage gated potassium channel 0.001 0.0006 0.0006
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0042 0.0144 0.0137
Loa Loa (eye worm) dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni coup transcription factor 0.0022 0.0058 0.0058
Schistosoma mansoni hypothetical protein 0.0037 0.0125 0.0125
Brugia malayi hypothetical protein 0.001 0.0007 0.0007
Leishmania major pyruvate kinase 0.0036 0.0122 0.0112
Plasmodium falciparum pyruvate kinase 0.0036 0.0122 0.7917
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) MH2 domain-containing protein 0.0131 0.0537 0.0537
Schistosoma mansoni nuclear receptor nhr-48 0.001 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Onchocerca volvulus Pyruvate kinase homolog 0.0036 0.0122 0.0115
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Brugia malayi tailless protein 0.001 0.0007 0.0007
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0058
Schistosoma mansoni cytochrome P450 0.0015 0.0028 0.0028
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi Dehydrogenases, short chain protein 30 0.0042 0.0144 0.0144
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0132 0.0132
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0046 0.154
Loa Loa (eye worm) hypothetical protein 0.097 0.4244 0.4244
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0042 0.0144 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0042 0.0144 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0046 0.154
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0075 0.4043
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0075 0.0056
Onchocerca volvulus 0.0049 0.0178 0.0171
Onchocerca volvulus 0.0042 0.0144 0.0137
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus granulosus pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0075 0.4043
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0058 0.0058
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0042 0.0144 0.0144
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1898 0.834 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0125
Plasmodium falciparum acyl-CoA synthetase 0.0019 0.0046 0.0864
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1898 0.834 0.834
Schistosoma mansoni hypothetical protein 0.0017 0.0037 0.0037
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0042 0.0144 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0058 0.0058
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Leishmania major C-8 sterol isomerase-like protein 0.1898 0.834 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0042 0.0144 1
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus granulosus pyruvate kinase 0.0019 0.0043 0.0043
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0042 0.0144 0.0139
Onchocerca volvulus 0.0042 0.0144 0.0137
Leishmania major cytochrome p450-like protein 0.0023 0.0062 0.004
Mycobacterium ulcerans carveol-like dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Onchocerca volvulus 0.0026 0.0075 0.0069
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0006
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.001 0.0007 0.0007
Brugia malayi nuclear hormone receptor family member odr-7 0.001 0.0007 0.0007
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Giardia lamblia Reductase, putative 0.0042 0.0144 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0042 0.0144 0.0144
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0042 0.0144 0.0144
Mycobacterium ulcerans pyruvate kinase 0.0036 0.0122 0.8071
Echinococcus granulosus nuclear receptor nhr 48 0.001 0.0007 0.0007
Brugia malayi photoreceptor-specific nuclear receptor 0.028 0.1198 0.1198
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0042 0.0144 0.0139
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Echinococcus multilocularis thyroid hormone receptor alpha 0.0022 0.0058 0.0058
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0058
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0037 0.0037
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0058 0.0058
Mycobacterium ulcerans hypothetical protein 0.0026 0.0075 0.4043
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Onchocerca volvulus Protein ultraspiracle homolog 0.0022 0.0058 0.0052
Schistosoma mansoni pyruvate kinase 0.0036 0.0122 0.0122
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0042 0.0144 1
Echinococcus multilocularis pyruvate kinase 0.0029 0.0088 0.0088
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0058 0.0058
Onchocerca volvulus 0.0042 0.0144 0.0137
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0042 0.0144 0.0144
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0042 0.0144 0.0137
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0075 0.0302
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Toxoplasma gondii oxidoreductase, putative 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Mycobacterium leprae Probable pyruvate kinase PykA 0.0036 0.0122 0.8071
Brugia malayi cytochrome P450 0.0015 0.0028 0.0028
Trypanosoma brucei C-8 sterol isomerase, putative 0.1898 0.834 1
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0043 0.0596
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0201 0.0201
Echinococcus granulosus steroid dehydrogenase 0.0042 0.0144 0.0144
Onchocerca volvulus Bile acid receptor homolog 0.0022 0.0058 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0058 0.0058
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0042 0.0144 0.0139
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0075 0.4043
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0075 0.4043
Brugia malayi hypothetical protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Toxoplasma gondii pyruvate kinase PyK1 0.0036 0.0122 0.8071
Onchocerca volvulus 0.0042 0.0144 0.0137
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0075 0.4043
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0058 0.0058
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Echinococcus multilocularis nuclear receptor nhr 48 0.001 0.0007 0.0007
Echinococcus granulosus vesicular acetylcholine transporter 0.2274 1 1
Trypanosoma brucei pyruvate kinase 1, putative 0.0036 0.0122 0.0112
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.0007
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0042 0.0144 1
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0058 0.0058
Mycobacterium ulcerans ketoacyl reductase 0.0042 0.0144 1
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0042 0.0144 0.0144
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Schistosoma mansoni nuclear receptor 0.001 0.0007 0.0007
Brugia malayi hypothetical protein 0.0042 0.0144 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0065 0.0248 0.0248
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0122 0.0112
Echinococcus multilocularis carbonyl reductase 1 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0042 0.0144 1
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Brugia malayi hypothetical protein 0.0134 0.0552 0.0552
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0042 0.0144 0.0137
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Leishmania major short chain dehydrogenase-like protein 0.0042 0.0144 0.0139
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0042 0.0144 1
Brugia malayi Cytochrome P450 family protein 0.0023 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0075
Plasmodium vivax pyruvate kinase, putative 0.0036 0.0122 0.7917
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0037 0.0037
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Echinococcus multilocularis pyruvate kinase 0.0036 0.0122 0.0122
Echinococcus multilocularis oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0037 0.0037
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.001 0.0006 0.0006
Echinococcus granulosus hypothetical protein 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0026 0.0075 0.0056
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0012 0.0012
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0058 0.0058
Brugia malayi Cytochrome P450 family protein 0.0023 0.0062 0.0062
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0037 0.001
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0037 0.0741
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0042 0.0144 1
Brugia malayi nuclear hormone receptor 0.0022 0.0058 0.0058
Brugia malayi Retinol dehydrogenase 12 0.0042 0.0144 0.0144
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0058 0.0058
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 1
Echinococcus granulosus GPCR family 2 0.0017 0.0037 0.0037
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0075 0.0302
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0042 0.0144 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase 0.0042 0.0144 0.0144
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0058 0.0058
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0118 0.0118
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0042 0.0144 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0122 0.3881
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0043 0.0596
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0042 0.0144 1
Leishmania major short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 0.0139
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0042 0.0144 1
Onchocerca volvulus 0.0042 0.0144 0.0137
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0007 0.0007
Brugia malayi Cytochrome P450 family protein 0.0065 0.0248 0.0248
Trichomonas vaginalis steroid dehydrogenase, putative 0.0042 0.0144 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0007
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.001 0.0007 0.0007
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) transcription factor SMAD2 0.0131 0.0537 0.0537
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0062 0.0062
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2274 1 1
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0042 0.0144 1
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Echinococcus multilocularis Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0037 0.0741
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0134 0.0552 0.0552
Mycobacterium ulcerans oxidoreductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0058 0.0058
Giardia lamblia Short-chain dehydrogenase, putative 0.0042 0.0144 1
Plasmodium vivax steroid dehydrogenase, putative 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0058 0.0058
Onchocerca volvulus 0.0042 0.0144 0.0137
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0042 0.0144 0.0139
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Echinococcus granulosus retinol dehydrogenase 11 0.0042 0.0144 0.0144
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0042 0.0144 0.0144
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0058 0.0058
Echinococcus multilocularis steroid dehydrogenase 0.0042 0.0144 0.0144
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0022 0.0058 0.0052
Echinococcus granulosus thyroid hormone receptor alpha 0.001 0.0007 0.0007
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Mycobacterium ulcerans short-chain dehydrogenase 0.0042 0.0144 1
Giardia lamblia Pyruvate kinase 0.0036 0.0122 0.7785
Brugia malayi nuclear hormone receptor family member nhr-6 0.001 0.0007 0.0007
Echinococcus granulosus hypothetical protein 0.0042 0.0144 0.0144
Brugia malayi ecdysone receptor 0.001 0.0007 0.0007
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0042 0.0144 0.0139
Echinococcus granulosus pyruvate kinase 0.0036 0.0122 0.0122
Loa Loa (eye worm) nuclear hormone receptor 0.001 0.0007 0.0007
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0043 0.1293
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.001 0.0007 0.0007
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0058 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0058
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0144 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0075 0.4043
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Brugia malayi hypothetical protein 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0042 0.0144 1
Mycobacterium ulcerans dehydrogenase/reductase 0.0042 0.0144 1
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Loa Loa (eye worm) oxidoreductase 0.0042 0.0144 0.0144
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0037 0.0037
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0023 0.0062 0.2899
Brugia malayi dehydrogenases, short chain protein 2 0.0042 0.0144 0.0144
Brugia malayi orphan nuclear receptor NR2E1 0.001 0.0007 0.0007
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.001 0.0007 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0037 0.0037
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0037 0.0741
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Trichomonas vaginalis pyruvate kinase, putative 0.0036 0.0122 0.3881
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0062 0.004
Loa Loa (eye worm) STAT protein 0.0173 0.0723 0.0723
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Echinococcus multilocularis GPCR, family 2 0.0017 0.0037 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Schistosoma mansoni thyroid hormone receptor 0.0022 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.001 0.0006 0.0006
Plasmodium vivax acyl-CoA synthetase, putative 0.0019 0.0046 0.0864
Leishmania major dehydrogenase-like protein 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0201 0.0201
Echinococcus granulosus carbonyl reductase 1 0.0042 0.0144 0.0144
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Onchocerca volvulus 0.0042 0.0144 0.0137
Brugia malayi MH2 domain containing protein 0.0131 0.0537 0.0537
Echinococcus granulosus Nuclear hormone receptor HR96 0.001 0.0007 0.0007
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0042 0.0144 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0037 0.001
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Brugia malayi steroid hormone receptor 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0144
Trypanosoma cruzi pyruvate kinase 2, putative 0.0036 0.0122 0.0112
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Echinococcus multilocularis 0.0015 0.0028 0.0028
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0075 0.0302
Loa Loa (eye worm) DR-78 0.001 0.0007 0.0007
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Brugia malayi hypothetical protein 0.0012 0.0012 0.0012
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0058 0.0058
Echinococcus multilocularis retinol dehydrogenase 11 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Schistosoma mansoni steroid dehydrogenase 0.0042 0.0144 0.0144
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.1898 0.834 0.834
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus granulosus retinol dehydrogenase 11 0.0042 0.0144 0.0144
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0042 0.0144 1
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Echinococcus granulosus WW domain containing oxidoreductase 0.0042 0.0144 0.0144
Leishmania major hypothetical protein, conserved 0.0042 0.0144 0.0139
Brugia malayi Nuclear hormone receptor E75 0.001 0.0007 0.0007
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0037 0.001
Echinococcus granulosus potassium voltage gated channel subfamily H 0.001 0.0006 0.0006
Onchocerca volvulus 0.0042 0.0144 0.0137
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0012
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0012 0.0012 0.0012
Brugia malayi STAT protein, DNA binding domain containing protein 0.0173 0.0723 0.0723
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0042 0.0144 0.0139
Schistosoma mansoni hypothetical protein 0.0015 0.0028 0.0028
Mycobacterium ulcerans ketoacyl reductase 0.0042 0.0144 1
Mycobacterium ulcerans dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni short chain dehydrogenase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0058 0.0058
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0042 0.0144 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0037 0.0037
Onchocerca volvulus Huntingtin homolog 0.0134 0.0552 0.0546
Echinococcus multilocularis retinol dehydrogenase 11 0.0042 0.0144 0.0144
Toxoplasma gondii oxidoreductase, putative 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0058 0.0058
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Chlamydia trachomatis pyruvate kinase 0.0036 0.0122 1
Leishmania major pyruvate kinase 0.0036 0.0122 0.0112
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0037 0.0037
Echinococcus multilocularis pyruvate kinase 0.0019 0.0043 0.0043
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0042 0.0144 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0073 0.0073
Schistosoma mansoni zinc finger protein 0.001 0.0007 0.0007
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Trypanosoma cruzi short chain dehydrogenase, putative 0.0042 0.0144 0.0139
Echinococcus multilocularis retinol dehydrogenase 13 0.0042 0.0144 0.0144
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0058 0.0058
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0037 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus granulosus cytochrome P450 2K1 0.0015 0.0028 0.0028
Plasmodium falciparum steroid dehydrogenase, putative 0.0042 0.0144 1
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0012 0.0012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0042 0.0144 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0019 0.0046 0.0046
Echinococcus multilocularis steroid dehydrogenase 0.0042 0.0144 0.0144
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0042 0.0144 0.0144
Trypanosoma brucei short-chain dehydrogenase, putative 0.0042 0.0144 0.0139
Schistosoma mansoni vesicular acetylcholine transporter 0.2274 1 1
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.001 0.0007 0.0007
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0042 0.0144 0.0139
Loa Loa (eye worm) hypothetical protein 0.0042 0.0144 0.0144
Leishmania major 3-keto-dihydrosphingosine reductase 0.0042 0.0144 0.0139
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0118 0.0118
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0042 0.0144 0.0144
Leishmania major quinonoid dihydropteridine reductase 0.0042 0.0144 0.0139
Entamoeba histolytica short chain dehydrogenase family protein 0.0042 0.0144 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0058 0.0058
Brugia malayi nuclear receptor RXR 0.0012 0.0012 0.0012
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0026 0.0075 0.4043
Mycobacterium ulcerans short-chain type oxidoreductase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0042 0.0144 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0037 0.0037
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0062 0.004
Loa Loa (eye worm) hypothetical protein 0.0026 0.0075 0.0075
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0058 0.0058
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0042 0.0144 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0042 0.1137
Brugia malayi nuclear receptor RXR 0.001 0.0007 0.0007
Giardia lamblia Hypothetical protein 0.0042 0.0144 1
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0144 0.0139
Schistosoma mansoni pyruvate kinase 0.0019 0.0043 0.0043
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Schistosoma mansoni retinal dehydrogenase 0.0042 0.0144 0.0144
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0058 0.0058
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0042 0.0144 0.0144
Entamoeba histolytica hypothetical protein, conserved 0.0042 0.0144 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0075 0.4043
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0037 0.0037
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0058 0.0058
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0075 0.4043
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0075 0.0075
Loa Loa (eye worm) pyruvate kinase-PB 0.0025 0.0073 0.0073
Loa Loa (eye worm) pyruvate kinase 0.0036 0.0122 0.0122
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0012 0.0012 0.0012
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0042 0.0144 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0125 0.0125
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0118 0.0118
Mycobacterium tuberculosis Probable oxidoreductase 0.0042 0.0144 1
Brugia malayi Dehydrogenases, short chain protein 2 0.0042 0.0144 0.0144
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0042 0.0144 1
Brugia malayi conserved hypotetical protein 0.001 0.0007 0.0007
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0042 0.0144 0.0144
Mycobacterium ulcerans short chain dehydrogenase 0.0042 0.0144 1
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0042 0.0144 0.0139

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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