Detailed information for compound 993029

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 310.296 | Formula: C15H16F2N2O3
  • H donors: 1 H acceptors: 1 LogP: 1.74 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1coc(n1)[C@H]([C@@H]1CNCCO1)Oc1c(F)cccc1F
  • InChi: 1S/C15H16F2N2O3/c1-9-8-21-15(19-9)14(12-7-18-5-6-20-12)22-13-10(16)3-2-4-11(13)17/h2-4,8,12,14,18H,5-7H2,1H3/t12-,14-/m0/s1
  • InChiKey: GPVPGABIUWQWLB-JSGCOSHPSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi MH2 domain containing protein 0.0101 0.057 0.057
Mycobacterium tuberculosis Probable dehydrogenase 0.0079 0.0431 0.1227
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0016 0.0017 0.0226
Mycobacterium tuberculosis Probable hydrolase 0.0086 0.0478 0.1363
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0089 0.0251
Loa Loa (eye worm) hypothetical protein 0.008 0.0434 0.0434
Brugia malayi phospholipase C homolog 0.0017 0.0027 0.0027
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.012 0.0176
Echinococcus granulosus bloom syndrome protein 0.0056 0.0281 0.0581
Leishmania major cyclic nucleotide-binding protein-like protein 0.0031 0.012 0.0492
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Onchocerca volvulus 0.0069 0.0366 0.0373
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0132 0.0772 0.101
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.012 0.0156
Echinococcus granulosus ral guanine nucleotide dissociation 0.0017 0.0027 0.0057
Loa Loa (eye worm) hypothetical protein 0.1553 1 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0095 0.1778
Echinococcus granulosus segment polarity protein dishevelled 0.0071 0.0379 0.0784
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0013 0.0001 0.0014
Echinococcus granulosus thioredoxin glutathione reductase 0.0035 0.0142 0.0293
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0071 0.0379 0.0379
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0034 0.0136 0.2786
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0089 0.0089
Echinococcus granulosus cAMP dependent protein kinase type I beta 0.0031 0.012 0.0247
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0089 0.1857
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0031 0.012 0.0156
Echinococcus granulosus mothers against decapentaplegic 6 0.0045 0.0209 0.0431
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.1563
Schistosoma mansoni glycosyltransferase-related 0.0051 0.0249 0.0366
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0051 0.0247 0.051
Schistosoma mansoni camp-dependent protein kinase type II regulatory subunit 0.0031 0.012 0.0176
Leishmania major protein kinase, putative 0.0031 0.012 0.0492
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.0778 0.0778
Schistosoma mansoni ran 0.0016 0.0018 0.0026
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Loa Loa (eye worm) hypothetical protein 0.0086 0.0478 0.0478
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0086 0.0478 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 0.562
Echinococcus multilocularis regulator of G protein signaling 7 0.0071 0.0379 0.0496
Mycobacterium leprae Conserved hypothetical protein 0.0031 0.012 0.2439
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0089 0.0089
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0054 0.027 0.0768
Mycobacterium leprae conserved hypothetical protein 0.0086 0.0478 0.9795
Echinococcus granulosus Smad4 0.0101 0.057 0.1178
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0434 0.0567
Trypanosoma brucei trypanothione reductase 0.0035 0.0142 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0231
Echinococcus multilocularis segment polarity protein dishevelled 0.0071 0.0379 0.0496
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0017 0.0027 0.0036
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0028 0.0244
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0031 0.012 0.0247
Brugia malayi Probable isocitrate dehydrogenase 0.0016 0.002 0.002
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0013 0.0001 0.0014
Echinococcus granulosus cAMP dependent protein kinase regulatory 0.0031 0.012 0.0247
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0016 0.0018 0.0229
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.005 0.0239 0.0312
Leishmania major cathepsin L-like protease 0.0046 0.0212 0.0872
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.012 0.0176
Trypanosoma cruzi hypothetical protein 0.0051 0.0247 0.1014
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0054 0.0632
Trichomonas vaginalis ras GTP exchange factor, putative 0.0017 0.0027 0.0231
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0016 0.0018 0.0207
Loa Loa (eye worm) thioredoxin reductase 0.0035 0.0142 0.0142
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0032 0.0122 0.1585
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0215 0.0281
Echinococcus granulosus GPCR family 2 0.0491 0.3107 0.6422
Treponema pallidum cyclic nucleotide binding protein 0.0031 0.012 0.2378
Trichomonas vaginalis ras GTP exchange factor, putative 0.0017 0.0027 0.0231
Loa Loa (eye worm) DIX domain-containing protein 0.0071 0.0379 0.0379
Brugia malayi jmjC domain containing protein 0.0034 0.0139 0.0139
Schistosoma mansoni jumonji domain containing protein 0.0128 0.075 0.1101
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.012 0.0176
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.012 0.2229
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0051 0.0249 0.5098
Schistosoma mansoni hypothetical protein 0.1062 0.681 1
Loa Loa (eye worm) hypothetical protein 0.0387 0.243 0.243
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.0461 0.2909 0.2909
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.012 0.012
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0045 0.0209 0.0204
Loa Loa (eye worm) MH1 domain-containing protein 0.0045 0.0209 0.0209
Plasmodium falciparum importin beta, putative 0.0021 0.0054 0.0699
Onchocerca volvulus 0.0056 0.0278 0.0278
Onchocerca volvulus 0.0031 0.012 0.0108
Trichomonas vaginalis D-aminoacylase, putative 0.0086 0.0478 1
Loa Loa (eye worm) hypothetical protein 0.1449 0.9322 0.9322
Schistosoma mansoni phosphatidylserine receptor 0.0034 0.0139 0.0204
Echinococcus multilocularis mothers against decapentaplegic 6 0.0045 0.0209 0.0273
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0434 0.562
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0051 0.0247 0.0362
Toxoplasma gondii hypothetical protein 0.0071 0.0379 0.4442
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.002
Brugia malayi RasGEF domain containing protein 0.0051 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0491 0.3107 0.4563
Loa Loa (eye worm) hypothetical protein 0.0032 0.0122 0.0122
Brugia malayi AMP-binding enzyme family protein 0.0056 0.0278 0.0278
Trypanosoma brucei protein kinase A regulatory subunit 0.0031 0.012 0.0492
Loa Loa (eye worm) MH2 domain-containing protein 0.1477 0.9508 0.9508
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.012 0.2229
Mycobacterium ulcerans beta-lactamase 0.0086 0.0478 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0051 0.0249 0.0709
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.012 0.2229
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.007 0.0091
Brugia malayi N-terminal motif family protein 0.1449 0.9322 0.9322
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Echinococcus multilocularis Smad4 0.0101 0.057 0.0745
Mycobacterium ulcerans esterase/lipase LipP 0.0086 0.0478 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0079 0.0431 0.8823
Schistosoma mansoni jumonji/arid domain-containing protein 0.0133 0.0778 0.1142
Brugia malayi Bloom's syndrome protein homolog 0.0056 0.0281 0.0281
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0031 0.012 0.0176
Plasmodium falciparum cGMP-dependent protein kinase 0.0031 0.012 0.1548
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.1563
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0079 0.0431 0.1227
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0054
Echinococcus granulosus vesicular acetylcholine transporter 0.0461 0.2909 0.6014
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0097 0.0547 0.0547
Mycobacterium ulcerans hypothetical protein 0.0027 0.0089 0.1857
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0017 0.0027 0.0057
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0155 0.0638
Loa Loa (eye worm) hypothetical protein 0.0071 0.0379 0.0379
Echinococcus granulosus Pleckstrin G protein interacting region 0.0071 0.0379 0.0784
Treponema pallidum catabolite gene activator 0.0031 0.012 0.2378
Schistosoma mansoni hypothetical protein 0.0031 0.012 0.0176
Mycobacterium ulcerans thioesterase 0.0043 0.0194 0.4052
Loa Loa (eye worm) hypothetical protein 0.0198 0.1201 0.1201
Mycobacterium tuberculosis Probable esterase LipL 0.0086 0.0478 0.1363
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.012
Toxoplasma gondii hypothetical protein 0.0027 0.0095 0.1109
Schistosoma mansoni importin beta-1 0.0021 0.0054 0.0079
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.0461 0.2909 0.3107
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0212 0.0872
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0086 0.0478 0.1363
Schistosoma mansoni hypothetical protein 0.026 0.1606 0.2358
Loa Loa (eye worm) MH1 domain-containing protein 0.0101 0.057 0.057
Plasmodium vivax rap guanine nucleotide exchange factor, putative 0.0031 0.012 0.1548
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.012 0.0693 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.1062 0.681 0.681
Schistosoma mansoni methyltransferase-related 0.0015 0.0017 0.0025
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 0.9077
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.012 0.0176
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0089 0.1857
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0016 0.0018 0.009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0139 0.0571
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0031 0.012 0.0492
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0089 0.1056
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0089 0.0089
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0039 0.0082
Plasmodium falciparum thioredoxin reductase 0.0035 0.0142 0.1838
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0128 0.075 0.1549
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0089
Brugia malayi glutathione reductase 0.0035 0.0142 0.0142
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.0189 0.0536
Brugia malayi AT16019p 0.0013 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Toxoplasma gondii ABC1 family protein 0.0086 0.0478 0.5596
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0013 0.0001 0.0014
Echinococcus granulosus mothers against decapentaplegic 5 0.0101 0.057 0.1178
Schistosoma mansoni blooms syndrome DNA helicase 0.0016 0.0021 0.0031
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0139
Echinococcus multilocularis isocitrate dehydrogenase 0.0132 0.0772 0.101
Trichomonas vaginalis helicase, putative 0.0017 0.0029 0.0259
Echinococcus multilocularis smad 0.0101 0.057 0.0745
Leishmania major trypanothione reductase 0.0035 0.0142 0.0584
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0249 0.5212
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0095 0.1228
Trichomonas vaginalis DNA helicase recq1, putative 0.0056 0.0281 0.5726
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0212 0.0872
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.1563
Treponema pallidum cyclic nucleotide binding protein 0.0031 0.012 0.2378
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0016 0.0018 0.0018
Echinococcus multilocularis cAMP dependent protein kinase type I beta 0.0031 0.012 0.0156
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Echinococcus multilocularis lysosomal alpha glucosidase 0.012 0.0693 0.0906
Loa Loa (eye worm) hypothetical protein 0.0056 0.0278 0.0278
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0132 0.0772 0.1596
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0018 0.0073
Echinococcus granulosus GTP binding nuclear protein Ran 0.0016 0.0018 0.0037
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0016 0.002 0.0427
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0039 0.0167 0.0345
Mycobacterium ulcerans hypothetical protein 0.0031 0.012 0.2501
Mycobacterium tuberculosis Probable 3-isopropylmalate dehydrogenase LeuB (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH) 0.0016 0.002 0.0056
Trichomonas vaginalis ras guanine nucleotide exchange factor, slime mold, putative 0.0017 0.0027 0.0231
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0051 0.0247 0.1014
Echinococcus multilocularis vesicular acetylcholine transporter 0.0461 0.2909 0.3805
Mycobacterium tuberculosis Probable conserved transmembrane transport protein 0.0032 0.0122 0.0347
Echinococcus multilocularis ral guanine nucleotide dissociation 0.0017 0.0027 0.0036
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0139
Echinococcus multilocularis beta LACTamase domain containing family member 0.0086 0.0478 0.0625
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.007 0.0144
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0434 0.508
Schistosoma mansoni DNA helicase recq1 0.0032 0.0122 0.018
Brugia malayi Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative 0.0031 0.012 0.012
Echinococcus multilocularis mothers against decapentaplegic 5 0.0101 0.057 0.0745
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1191 0.7647 1
Mycobacterium tuberculosis Conserved protein 0.0031 0.012 0.0339
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Leishmania major isocitrate dehydrogenase, putative 0.0016 0.002 0.0084
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 1
Loa Loa (eye worm) glutathione reductase 0.0035 0.0142 0.0142
Mycobacterium tuberculosis Probable glutamine-transport ATP-binding protein ABC transporter GlnQ 0.0031 0.012 0.0339
Loa Loa (eye worm) hypothetical protein 0.0034 0.0139 0.0139
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0387 0.243 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0491 0.3107 0.6422
Trypanosoma cruzi cyclic nucleotide-binding domain containing protein, putative 0.0031 0.012 0.0492
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0259
Schistosoma mansoni hypothetical protein 0.0491 0.3107 0.4563
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0101 0.057 0.0837
Schistosoma mansoni tar DNA-binding protein 0.0453 0.286 0.42
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.027 0.0768
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0086 0.0478 0.1363
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Trichomonas vaginalis cAMP-dependent protein kinase regulatory subunit, putative 0.0031 0.012 0.2229
Entamoeba histolytica RasGEF domain containing protein 0.0017 0.0027 0.0147
Echinococcus granulosus mothers against decapentaplegic 2 0.0045 0.0209 0.0431
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0028 0.0115
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0089 0.0365
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0071 0.0379 0.0379
Plasmodium vivax importin-beta 2, putative 0.0021 0.0054 0.0699
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0231
Echinococcus multilocularis cAMP dependent protein kinase regulatory 0.0031 0.012 0.0156
Schistosoma mansoni hypothetical protein 0.0491 0.3107 0.4563
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0054 0.0222
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0031 0.012 0.0492
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0045 0.0586
Brugia malayi jmjC domain containing protein 0.0034 0.0139 0.0139
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0132 0.0772 0.3177
Loa Loa (eye worm) hypothetical protein 0.0029 0.0103 0.0103
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0034 0.0139 0.0571
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0122 0.1433
Loa Loa (eye worm) MH2 domain-containing protein 0.0101 0.057 0.057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0039 0.0052
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.012 0.0247
Schistosoma mansoni Smad4 0.0045 0.0209 0.0306
Brugia malayi latrophilin 2 splice variant baaae 0.1062 0.681 0.681
Schistosoma mansoni tar DNA-binding protein 0.0453 0.286 0.42
Giardia lamblia Sgs1 DNA helicase, putative 0.0032 0.0122 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0086 0.0478 0.0988
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0259
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Echinococcus granulosus cpg binding protein 0.0081 0.044 0.0909
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0034 0.0139 0.1623
Schistosoma mansoni jumonji/arid domain-containing protein 0.0133 0.0778 0.1142
Echinococcus multilocularis lysine specific demethylase 6a 0.0034 0.0139 0.0181
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0029 0.0259
Loa Loa (eye worm) MH2 domain-containing protein 0.0045 0.0209 0.0209
Leishmania major hypothetical protein, conserved 0.0031 0.012 0.0492
Mycobacterium tuberculosis Conserved protein 0.0086 0.0478 0.1363
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0478 0.1967
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0231
Trypanosoma cruzi hypothetical protein, conserved 0.0086 0.0478 0.1967
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0132 0.0772 0.3177
Brugia malayi Importin beta-1 subunit 0.0021 0.0054 0.0054
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0016 0.0019 0.0052
Echinococcus multilocularis jumonji domain containing 1A 0.0034 0.0139 0.0181
Echinococcus granulosus TGF beta signal transducer SmadC 0.0101 0.057 0.1178
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0491 0.3107 0.6422
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0553 0.3504 1
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.005 0.0239 0.0312
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0051 0.0247 0.0362
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0027 0.0095 0.1931
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.012 0.0176
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Schistosoma mansoni hypothetical protein 0.026 0.1606 0.2358
Echinococcus multilocularis bloom syndrome protein 0.0056 0.0281 0.0367
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0089 0.0251
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0021 0.0088
Onchocerca volvulus 0.0086 0.0478 0.0493
Brugia malayi Glycosyl transferase family 8 protein 0.0051 0.0249 0.0249
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0031 0.012 0.012
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0051 0.0247 0.0362
Echinococcus granulosus phd:f box containing protein 0.0034 0.0139 0.0287
Onchocerca volvulus Fatty acid synthase homolog 0.0092 0.0516 0.0534
Brugia malayi beta-lactamase family protein 0.0086 0.0478 0.0478
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0071 0.0379 0.0496
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0034 0.0139 0.0204
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0016 0.0018 0.0018
Trichomonas vaginalis cAMP-dependent protein kinase type I-beta regulatory subunit, putative 0.0031 0.012 0.2229
Brugia malayi isocitrate dehydrogenase 0.0132 0.0772 0.0772
Schistosoma mansoni alpha glucosidase 0.0027 0.0089 0.013
Brugia malayi beta-lactamase 0.0086 0.0478 0.0478
Echinococcus granulosus geminin 0.026 0.1606 0.332
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0035 0.0143 0.1676
Trypanosoma cruzi cysteine peptidase, putative 0.0046 0.0212 0.0872
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.027 0.5644
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0051 0.0247 0.4981
Brugia malayi MH1 domain containing protein 0.0056 0.0278 0.0278
Leishmania major regulatory subunit of protein kinase a-like protein 0.0031 0.012 0.0492
Brugia malayi RNA, U transporter 1 0.006 0.0307 0.0307
Echinococcus multilocularis tar DNA binding protein 0.0453 0.286 0.374
Brugia malayi jmjC domain containing protein 0.0128 0.075 0.075
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0249 0.5212
Brugia malayi RasGEF domain containing protein 0.0051 0.0247 0.0247
Schistosoma mansoni smad 0.0101 0.057 0.0837
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0031 0.012 0.0156
Schistosoma mansoni ral guanine nucleotide exchange factor with pH domain and sh3 binding motif ralgps 0.0017 0.0027 0.004
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0051 0.0249 0.0249
Schistosoma mansoni hypothetical protein 0.0046 0.0215 0.0315
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Echinococcus granulosus smad 0.0101 0.057 0.1178
Mycobacterium tuberculosis Probable reductase 0.0079 0.0431 0.1227
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0139 0.0139
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0016 0.002 0.0042
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0032 0.0122 0.0253
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0086 0.0478 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0034 0.0139 0.0571
Brugia malayi MH2 domain containing protein 0.1477 0.9508 0.9508
Schistosoma mansoni phd/f-box containing protein 0.0034 0.0139 0.0204
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0231
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0089 0.1857
Brugia malayi hypothetical protein 0.0071 0.0379 0.0379
Schistosoma mansoni dep domain containing protein 0.0071 0.0379 0.0557
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0155 0.0638
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0031 0.012 0.1399
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0032 0.0122 0.0253
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.012 0.2229
Brugia malayi jmjC domain containing protein 0.0133 0.0778 0.0778
Mycobacterium ulcerans regulatory protein 0.0031 0.012 0.2501
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0256 0.0728
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0132 0.0772 0.2202
Schistosoma mansoni z-protein (S1r protein) 0.0071 0.0379 0.0557
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.012 0.0693 0.0693
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0153 0.1794
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Brugia malayi mothers against decapentaplegic homolog 3 0.0045 0.0209 0.0209
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.012 0.0492
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0036 0.0147 0.1906
Leishmania major alpha glucosidase II subunit, putative 0.0027 0.0089 0.0366
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0086 0.0478 0.0702
Echinococcus granulosus son of sevenless 1 0.0051 0.0247 0.051
Loa Loa (eye worm) hypothetical protein 0.0086 0.0478 0.0478
Schistosoma mansoni cpg binding protein 0.0076 0.0411 0.0604
Plasmodium vivax hypothetical protein, conserved 0.0086 0.0478 0.6191
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0089 0.1857
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.0001 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.012 0.0176
Treponema pallidum catabolite gene activator (Crp) 0.0031 0.012 0.2378
Trichomonas vaginalis maltase-glucoamylase, putative 0.0027 0.0089 0.1563
Mycobacterium ulcerans transmembrane transport protein 0.0032 0.0122 0.2558
Schistosoma mansoni blooms syndrome DNA helicase 0.004 0.0176 0.0258
Loa Loa (eye worm) hypothetical protein 0.0071 0.0379 0.0379
Echinococcus granulosus snurportin 1 0.0226 0.1384 0.286
Echinococcus multilocularis son of sevenless 1 0.0051 0.0247 0.0322
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0027 0.0092 0.1073
Schistosoma mansoni similar to Protein C20orf152 homolog 0.0031 0.012 0.0176
Loa Loa (eye worm) hypothetical protein 0.0071 0.0379 0.0379
Trypanosoma cruzi trypanothione reductase, putative 0.0035 0.0142 0.0584
Brugia malayi hypothetical protein 0.0102 0.0581 0.0581
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0132 0.0772 0.3177
Loa Loa (eye worm) hypothetical protein 0.0086 0.0478 0.0478
Schistosoma mansoni cyclic nucleotide-gated ion channel 0.0031 0.012 0.0176
Leishmania major hypothetical protein, conserved 0.0102 0.0581 0.2391
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0031 0.012 0.0176
Onchocerca volvulus 0.0086 0.0478 0.0493
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0031 0.012 0.0247
Loa Loa (eye worm) hypothetical protein 0.0102 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.015 0.0892 0.0892
Schistosoma mansoni Smad4 0.0101 0.057 0.0837
Brugia malayi N-terminal motif family protein 0.0051 0.0247 0.0247
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0434 0.0897
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.012
Trypanosoma cruzi major cysteine proteinase, putative 0.0036 0.0149 0.0612
Toxoplasma gondii histone lysine methyltransferase SET1 0.0144 0.0854 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Brugia malayi Egg laying defective protein 4 0.0031 0.012 0.012
Echinococcus multilocularis expressed conserved protein 0.0031 0.012 0.0156
Trichomonas vaginalis ras GTP exchange factor, putative 0.0051 0.0247 0.4981
Leishmania major hypothetical protein, conserved 0.0031 0.012 0.0492
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0132 0.0772 0.3177
Schistosoma mansoni ral guanine nucleotide dissociation stimulator ralgds 0.0017 0.0027 0.004
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0089 0.0365
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0038 0.0107
Mycobacterium leprae PROBABLE 3-ISOPROPYLMALATE DEHYDROGENASE LEUB (BETA-IPM DEHYDROGENASE) (IMDH) (3-IPM-DH) 0.0016 0.002 0.0405
Brugia malayi N-terminal motif family protein 0.0051 0.0247 0.0247
Giardia lamblia CAMP-dependent protein kinase regulatory chain 0.0031 0.012 0.9732
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0089 0.1857
Trypanosoma cruzi cAMP response protein 1 0.0031 0.012 0.0492
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Echinococcus granulosus cGMP dependent protein kinase 1 0.0031 0.012 0.0247
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0071 0.0379 0.0379
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0581 0.7527
Brugia malayi RNA binding protein 0.0453 0.286 0.286
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0017 0.0027 0.0231
Loa Loa (eye worm) hypothetical protein 0.012 0.0693 0.0693
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0051 0.0247 0.0322
Trichomonas vaginalis ras GTP exchange factor, putative 0.0017 0.0027 0.0231
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0054 0.0222
Echinococcus multilocularis snurportin 1 0.0226 0.1384 0.181
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0035 0.0142 0.0403
Trypanosoma brucei hypothetical protein, conserved 0.0086 0.0478 0.1967
Leishmania major cathepsin L-like protease 0.0046 0.0212 0.0872
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0132 0.0772 0.101
Echinococcus multilocularis GPCR, family 2 0.0491 0.3107 0.4063
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0231
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0054 0.027 0.5522
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.012 0.0176
Schistosoma mansoni alpha-glucosidase 0.0103 0.0585 0.0859
Echinococcus multilocularis regulator of G protein signaling 7 0.0071 0.0379 0.0496
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.005 0.0239 0.068
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0089 0.0366
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.012 0.0176
Schistosoma mansoni pdz domain containing guanine nucleotide exchange factor pdz-gef 0.0017 0.0027 0.004
Trichomonas vaginalis isocitrate dehydrogenase, putative 0.0016 0.002 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Mycobacterium tuberculosis Probable thioesterase TesA 0.0043 0.0194 0.0551
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0089 0.1857
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Mycobacterium tuberculosis Probable lipase LipD 0.0086 0.0478 0.1363
Plasmodium vivax glutathione reductase, putative 0.0035 0.0142 0.1838
Leishmania major hypothetical protein, conserved 0.0034 0.0139 0.0571
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.012 0.0176
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0031 0.012 0.012
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0016 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Brugia malayi Probable ClpP-like protease 0.008 0.0434 0.0434
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.012 0.0156
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0581 0.2391
Toxoplasma gondii isocitrate dehydrogenase 0.0132 0.0772 0.9038
Trichomonas vaginalis D-aminoacylase, putative 0.0086 0.0478 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0071 0.0379 0.0496
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0089 0.1563
Onchocerca volvulus 0.0071 0.0379 0.0387
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.012 0.2229
Echinococcus granulosus patatin phospholipase domain containing protein 0.0031 0.012 0.0247
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0031 0.012 0.0247
Trypanosoma cruzi hypothetical protein 0.0051 0.0247 0.1014
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0037 0.0155 0.0638
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0017 0.0026 0.0026
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.012 0.0339
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0068 0.0068
Toxoplasma gondii isocitrate dehydrogenase 0.0132 0.0772 0.9038
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0027 0.0089 0.1563
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.012 0.0176
Loa Loa (eye worm) RasGEF domain-containing protein 0.0051 0.0247 0.0247
Schistosoma mansoni hypothetical protein 0.0758 0.4838 0.7104
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.0155 0.0442
Leishmania major GTP-binding protein, putative 0.0016 0.0018 0.0073
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.0249 0.0709
Plasmodium falciparum ataxin-2 like protein, putative 0.0102 0.0581 0.7527
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.012 0.0156
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0031 0.012 0.0156
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0088 0.0488 0.1391
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0016 0.0021 0.0088
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Brugia malayi jmjC domain containing protein 0.0034 0.0139 0.0139
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 0.9077
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 1
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0016 0.0021 0.0417
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0027 0.0089 0.104
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0031 0.012 0.0156
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0021 0.0251
Brugia malayi vesicular acetylcholine transporter unc-17 0.0461 0.2909 0.2909
Trichomonas vaginalis ras GTP exchange factor, putative 0.0051 0.0247 0.4981
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0031 0.012 0.0247
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0031 0.012 0.0156
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0077 0.0414 0.1179
Plasmodium falciparum cAMP-dependent protein kinase regulatory subunit 0.0031 0.012 0.1548
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0031 0.012 0.1399
Echinococcus granulosus ral guanine nucleotide exchange factor with pH 0.0017 0.0027 0.0057
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Brugia malayi RasGEF domain containing protein 0.0017 0.0027 0.0027
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0054 0.0071
Onchocerca volvulus 0.0097 0.0546 0.0566
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.0249 0.5212
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0231
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0226 0.1384 0.1384
Schistosoma mansoni hypothetical protein 0.0491 0.3107 0.4563
Loa Loa (eye worm) cAMP-dependent protein kinase regulatory subunit 0.0031 0.012 0.012
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0071 0.0379 0.0557
Echinococcus multilocularis cAMP dependent protein kinase type II regulatory 0.0031 0.012 0.0156
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.012 0.0176
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0051 0.0247 0.0244
Loa Loa (eye worm) latrophilin receptor protein 2 0.0491 0.3107 0.3107
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0042 0.0186 0.0767
Entamoeba histolytica recQ family DNA helicase 0.0016 0.0021 0.0059
Trichomonas vaginalis ran, putative 0.0016 0.0018 0.0021
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0256 0.0334
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0031 0.012 0.0339
Brugia malayi RNA recognition motif domain containing protein 0.0453 0.286 0.286
Brugia malayi hypothetical protein 0.0066 0.0346 0.0346
Echinococcus multilocularis lysine specific demethylase 5A 0.0128 0.075 0.098
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0048 0.023 0.0338
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0033 0.0132 0.1549
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.1449 0.9322 1
Echinococcus granulosus lysosomal alpha glucosidase 0.012 0.0693 0.1433
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0045 0.0946
Echinococcus granulosus lysine specific demethylase 6a 0.0034 0.0139 0.0287
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0016 0.002 0.002
Entamoeba histolytica hypothetical protein 0.0051 0.0247 0.3393
Schistosoma mansoni tar DNA-binding protein 0.0453 0.286 0.42
Schistosoma mansoni DNA helicase recq5 0.0032 0.0122 0.018
Mycobacterium ulcerans hypothetical protein 0.0031 0.012 0.2501
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0051 0.0247 0.0362
Echinococcus granulosus cGMP dependent protein kinase 1 0.0031 0.012 0.0247
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0089 0.1807
Echinococcus granulosus regulator of G protein signaling 7 0.0071 0.0379 0.0784
Trypanosoma cruzi hypothetical protein 0.0017 0.0027 0.0113
Echinococcus multilocularis geminin 0.026 0.1606 0.21
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0259
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0089 0.1057
Mycobacterium ulcerans polyketide synthase 0.0054 0.027 0.5644
Echinococcus granulosus neutral alpha glucosidase AB 0.0027 0.0089 0.0184
Mycobacterium tuberculosis Hypothetical protein 0.0015 0.0017 0.0046
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0054 0.027 0.5522
Leishmania major C-8 sterol isomerase-like protein 0.0387 0.243 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0256 0.5232
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.027 0.5644
Trypanosoma brucei cyclic nucleotide-binding domain containing protein, putative 0.0031 0.012 0.0492
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.0249 0.5212
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0095 0.1228
Schistosoma mansoni dishevelled 0.0071 0.0379 0.0557
Schistosoma mansoni camp-dependent protein kinase regulatory chain 0.0031 0.012 0.0176
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0038 0.0107
Mycobacterium ulcerans hypothetical protein 0.0031 0.012 0.2501
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0089 0.1056
Mycobacterium tuberculosis Probable transcriptional regulatory protein Cmr 0.0031 0.012 0.0339
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0434 0.0637
Schistosoma mansoni camp-dependent protein kinase type II-alpha regulatory subunit 0.0031 0.012 0.0176
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0027 0.0089 0.1057
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0039 0.0082
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 1
Trypanosoma brucei glucosidase, putative 0.0027 0.0089 0.0366
Echinococcus granulosus dnaJ subfamily B 0.0758 0.4838 1
Leishmania major hypothetical protein, conserved 0.0086 0.0478 0.1967
Onchocerca volvulus 0.0164 0.098 0.1033
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0122 0.0122
Echinococcus multilocularis lysosomal alpha glucosidase 0.012 0.0693 0.0906
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0088 0.0488 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.0482 0.0482
Trypanosoma cruzi protein kinase A regulatory subunit 0.0031 0.012 0.0492
Schistosoma mansoni jumonji domain containing protein 0.0034 0.0139 0.0204
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0045 0.1042
Mycobacterium ulcerans transcriptional regulatory protein 0.0031 0.012 0.2501
Entamoeba histolytica acyl-CoA synthetase, putative 0.0032 0.0122 0.1554
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0028 0.0244
Mycobacterium tuberculosis Conserved protein 0.0086 0.0478 0.1363
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Brugia malayi Isocitrate dehydrogenase 0.0132 0.0772 0.0772
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0128 0.075 0.098
Loa Loa (eye worm) hypothetical protein 0.0491 0.3107 0.3107
Echinococcus multilocularis voltage gated potassium channel 0.0031 0.012 0.0156
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0259
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Brugia malayi Smad1 0.0101 0.057 0.057
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.012 0.0693 1
Echinococcus multilocularis hyperpolarization activated cyclic 0.0031 0.012 0.0156
Mycobacterium tuberculosis Conserved hypothetical protein 0.0031 0.012 0.0339
Mycobacterium tuberculosis Polyketide synthase Pks2 0.005 0.0239 0.068
Echinococcus multilocularis glycosyltransferase protein LARGE2 0.005 0.0239 0.0312
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.012 0.0247
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0031 0.012 0.0176
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0039 0.0167 0.0218
Plasmodium vivax thioredoxin reductase, putative 0.0035 0.0142 0.1838
Brugia malayi CXXC zinc finger family protein 0.0076 0.0411 0.0411
Schistosoma mansoni tar DNA-binding protein 0.0453 0.286 0.42
Loa Loa (eye worm) histone methyltransferase 0.0024 0.007 0.007
Toxoplasma gondii type I fatty acid synthase, putative 0.0055 0.0277 0.3241
Echinococcus multilocularis neutral alpha glucosidase AB 0.0027 0.0089 0.0116
Brugia malayi cAMP-dependent protein kinase regulatory chain, putative 0.0031 0.012 0.012
Loa Loa (eye worm) RNA binding protein 0.0453 0.286 0.286
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Mycobacterium ulcerans polyketide synthase MbtD 0.0016 0.0019 0.0393
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.1563
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0056 0.0278 0.0791
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0034 0.0136 0.2855
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0051 0.0144
Leishmania major protein kinase, putative 0.0031 0.012 0.0492
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0045 0.0127
Trypanosoma cruzi regulatory subunit of protein kinase a-like protein, putative 0.0031 0.012 0.0492
Brugia malayi MH1 domain containing protein 0.0056 0.0278 0.0278
Brugia malayi MH1 domain containing protein 0.0101 0.057 0.057
Onchocerca volvulus 0.0031 0.012 0.0108
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0079 0.0431 0.1227
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.012 0.0247
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Plasmodium falciparum glutathione reductase 0.0035 0.0142 0.1838
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1553 1 1
Echinococcus multilocularis ras GTP exchange factor 0.0051 0.0247 0.0322
Onchocerca volvulus 0.0027 0.0089 0.0075
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0132 0.0772 0.101
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0016 0.002 0.0027
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0256 0.0728
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Trypanosoma cruzi PAB1-binding protein , putative 0.0102 0.0581 0.2391
Echinococcus granulosus jumonji domain containing 1A 0.0034 0.0139 0.0287
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0086 0.0478 0.0478
Plasmodium vivax ataxin-2 like protein, putative 0.0102 0.0581 0.7527
Mycobacterium leprae Polyketide synthase Pks13 0.0077 0.0414 0.8474
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0089 0.1857
Trypanosoma cruzi hypothetical protein 0.0017 0.0027 0.0113
Echinococcus multilocularis patatin phospholipase domain containing protein 0.0031 0.012 0.0156
Brugia malayi MH2 domain containing protein 0.0045 0.0209 0.0209
Echinococcus granulosus JmjC domain containing protein 4 0.0034 0.0139 0.0287
Entamoeba histolytica recQ family helicase, putative 0.0037 0.0155 0.204
Trypanosoma brucei cAMP response protein 1, putative 0.0031 0.012 0.0492
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Toxoplasma gondii LsmAD domain-containing protein 0.0102 0.0581 0.6803
Loa Loa (eye worm) hypothetical protein 0.0045 0.0209 0.0209
Leishmania major protein kinase A regulatory subunit, putative 0.0031 0.012 0.0492
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Trypanosoma cruzi cAMP response protein 1, putative 0.0031 0.012 0.0492
Brugia malayi regulator of G-protein signaling egl-10 0.0071 0.0379 0.0379
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0013 0.0001 0.0014
Schistosoma mansoni unc-13 (munc13) 0.0016 0.002 0.003
Schistosoma mansoni regulator of G protein signaling 0.0071 0.0379 0.0557
Plasmodium falciparum JmjC domain-containing protein, putative 0.0034 0.0139 0.1796
Echinococcus granulosus cAMP dependent protein kinase type II regulatory 0.0031 0.012 0.0247
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0028 0.0244
Trichomonas vaginalis D-aminoacylase, putative 0.0086 0.0478 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0031 0.012 0.012
Loa Loa (eye worm) Smad1 0.0101 0.057 0.057
Echinococcus multilocularis mothers against decapentaplegic 2 0.0045 0.0209 0.0273
Brugia malayi beta-lactamase family protein 0.0086 0.0478 0.0478
Echinococcus granulosus regulator of G protein signaling 7 0.0071 0.0379 0.0784
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0139 0.0139
Schistosoma mansoni dishevelled 0.0071 0.0379 0.0557
Echinococcus granulosus lysine specific demethylase 5A 0.0133 0.0778 0.1608
Echinococcus multilocularis Glycosyltransferase protein LARGE1 0.0038 0.0163 0.0214
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0041 0.0184 0.3852
Mycobacterium tuberculosis Probable oxidoreductase 0.0088 0.0488 0.1391
Trypanosoma cruzi cruzipain precursor, putative 0.0046 0.0212 0.0872
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Echinococcus multilocularis cGMP dependent protein kinase 1 0.0031 0.012 0.0156
Echinococcus multilocularis phd:f box containing protein 0.0034 0.0139 0.0181
Loa Loa (eye worm) hypothetical protein 0.0051 0.0247 0.0247
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0089 0.0365
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0051 0.0249 0.0709
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Brugia malayi Probable isocitrate dehydrogenase 0.0016 0.002 0.002
Leishmania major hypothetical protein, unknown function 0.0031 0.012 0.0492
Entamoeba histolytica hypothetical protein 0.0017 0.0028 0.0156
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0056 0.0278 0.0278
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0089 0.0366
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0215 0.0444
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0013 0.0001 0.0001
Brugia malayi DIX domain containing protein 0.0071 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0086 0.0478 0.0478
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0027
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0387 0.243 0.243
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0045 0.0586
Entamoeba histolytica Ran family GTPase 0.0016 0.0018 0.0003
Brugia malayi Cyclic-nucleotide gated cation channel, C. elegans tax-4 ortholog 0.0031 0.012 0.012
Schistosoma mansoni cpg binding protein 0.0081 0.044 0.0646
Trichomonas vaginalis guanine nucleotide exchange factor, putative 0.0051 0.0247 0.4981
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0051 0.0248 0.3213
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.012 0.2229
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.0089 0.0089
Loa Loa (eye worm) glycosyl transferase family 8 protein 0.0051 0.0249 0.0249
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0041 0.0184 0.3852
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0132 0.0772 1
Schistosoma mansoni Smad4 0.0045 0.0209 0.0306
Loa Loa (eye worm) hypothetical protein 0.0031 0.012 0.012
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0077 0.0414 0.1179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0038 0.0107
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0089 0.1807
Trypanosoma cruzi Flagellar Member 6 0.0031 0.012 0.0492
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0122 0.1433
Brugia malayi hypothetical protein 0.0164 0.098 0.098
Schistosoma mansoni vesicular acetylcholine transporter 0.0461 0.2909 0.4273
Mycobacterium ulcerans thioesterase TesA 0.0043 0.0194 0.4052
Trypanosoma brucei PAB1-binding protein , putative 0.0102 0.0581 0.2391
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Loa Loa (eye worm) hypothetical protein 0.0051 0.0247 0.0247
Echinococcus granulosus glycosyltransferase protein LARGE2 0.005 0.0239 0.0493
Echinococcus granulosus ras GTP exchange factor 0.0051 0.0247 0.051
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0086 0.0478 0.1363
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0031 0.012 0.0176
Brugia malayi RasGEF domain containing protein 0.0051 0.0247 0.0247
Loa Loa (eye worm) transcription factor SMAD2 0.1477 0.9508 0.9508
Toxoplasma gondii cAMP-dependent protein kinase regulatory subunit 0.0031 0.012 0.1399
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0086 0.0478 0.0478
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0016 0.0018 0.0023
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0032 0.0122 0.0122
Plasmodium vivax JmjC domain containing protein 0.0034 0.0139 0.1796
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.012 0.0176
Trichomonas vaginalis sucrase-isomaltase, putative 0.0027 0.0089 0.1563
Trichomonas vaginalis alpha-glucosidase, putative 0.0027 0.0089 0.1563
Echinococcus multilocularis cpg binding protein 0.0081 0.044 0.0575
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0016 0.002 0.003
Schistosoma mansoni hypothetical protein 0.0226 0.1384 0.2032
Echinococcus multilocularis Protein son of sevenless 0.0051 0.0247 0.0322
Leishmania major importin beta-1 subunit, putative 0.0017 0.0028 0.0115
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Brugia malayi Glycosyl hydrolases family 31 protein 0.012 0.0693 0.0693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0434 1
Brugia malayi Latrophilin receptor protein 2 0.0491 0.3107 0.3107
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Schistosoma mansoni smad1 5 8 and 0.0101 0.057 0.0837
Echinococcus multilocularis dnaJ subfamily B 0.0758 0.4838 0.6326
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0434 0.889
Schistosoma mansoni cpg binding protein 0.0081 0.044 0.0646
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0259
Mycobacterium ulcerans lipase LipD 0.0086 0.0478 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0031 0.012 0.012
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0027 0.0089 0.0089
Trichomonas vaginalis ras GTP exchange factor, putative 0.0017 0.0027 0.0231
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0051 0.0247 0.0322
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.0106 0.03
Mycobacterium leprae Probable lipase LipE 0.0086 0.0478 0.9795
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0256 0.0528
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0079 0.0431 0.1227
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0016 0.002 0.002
Leishmania major cathepsin L-like protease 0.0046 0.0212 0.0872
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0016 0.0018 0.0073
Schistosoma mansoni hypothetical protein 0.0017 0.0027 0.004
Schistosoma mansoni smad 0.0045 0.0209 0.0306
Echinococcus multilocularis conserved hypothetical protein 0.0038 0.0163 0.0214
Entamoeba histolytica tartrate dehydrogenase, putative 0.0016 0.002 0.0044
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0101 0.057 0.0745
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0453 0.286 0.286
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0038 0.0107
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Brugia malayi Thioredoxin reductase 0.0035 0.0142 0.0142
Trypanosoma brucei cAMP binding protein, putative 0.0031 0.012 0.0492
Schistosoma mansoni ran 0.0016 0.0018 0.0026
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0016 0.0021 0.0058
Schistosoma mansoni tar DNA-binding protein 0.0453 0.286 0.42
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0031 0.012 0.1399
Brugia malayi MH1 domain containing protein 0.0101 0.057 0.057
Trypanosoma brucei C-8 sterol isomerase, putative 0.0387 0.243 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0434 0.508
Schistosoma mansoni neuropathy target esterase/swiss cheese-related protein 0.0031 0.012 0.0176
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0016 0.002 0.0027
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0031 0.012 0.0156
Loa Loa (eye worm) beta-lactamase 0.0086 0.0478 0.0478
Echinococcus granulosus Glycosyltransferase protein LARGE1 0.0038 0.0163 0.0338
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0016 0.002 0.0042
Brugia malayi jmjC domain containing protein 0.0034 0.0139 0.0139
Schistosoma mansoni smad1 5 8 and 0.0101 0.057 0.0837
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0043 0.0194 0.3961
Mycobacterium ulcerans hypothetical protein 0.0031 0.012 0.2501
Brugia malayi MH2 domain containing protein 0.0101 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0086 0.0478 0.0478
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Loa Loa (eye worm) hypothetical protein 0.0086 0.0478 0.0478
Loa Loa (eye worm) fatty acid synthase 0.0051 0.0245 0.0245
Echinococcus multilocularis Glycosyl transferase, family 8 0.0051 0.0249 0.0326
Loa Loa (eye worm) RasGEF domain-containing protein 0.0017 0.0027 0.0027
Schistosoma mansoni protein phosphatase 2C 0.0034 0.0139 0.0204
Mycobacterium tuberculosis Conserved protein 0.0086 0.0478 0.1363
Trypanosoma cruzi cAMP binding protein, putative 0.0031 0.012 0.0492
Loa Loa (eye worm) AGC/PKG protein kinase 0.0031 0.012 0.012
Mycobacterium leprae Probable polyketide synthase Pks1 0.0054 0.027 0.5522
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0039 0.0058
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0132 0.0772 1
Mycobacterium tuberculosis Conserved protein 0.0015 0.0017 0.0046
Echinococcus multilocularis ral guanine nucleotide exchange factor with pH 0.0017 0.0027 0.0036
Loa Loa (eye worm) RasGEF domain-containing protein 0.0051 0.0247 0.0247
Mycobacterium ulcerans polyketide synthase Pks9 0.0034 0.0136 0.2855
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0032 0.0122 0.016
Mycobacterium ulcerans polyketide synthase 0.0051 0.0249 0.5212
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0071 0.0379 0.0387
Onchocerca volvulus 0.0051 0.0247 0.0244
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0041 0.0184 0.3765
Trypanosoma brucei Flagellar Member 6 0.0031 0.012 0.0492
Loa Loa (eye worm) isocitrate dehydrogenase 0.0132 0.0772 0.0772
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0016 0.0018 0.0229
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0034 0.0139 0.1623
Echinococcus granulosus segment polarity protein dishevelled 0.0071 0.0379 0.0784
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0016 0.002 0.002
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Echinococcus granulosus importin subunit beta 1 0.0021 0.0054 0.0112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0029 0.0259
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0132 0.0772 0.3177
Brugia malayi Methyltransferase-like protein 4 0.0015 0.0017 0.0017
Brugia malayi Cyclic-nucleotide gated cation channel 0.0031 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0089
Trichomonas vaginalis esterase, putative 0.0086 0.0478 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0051 0.0249 0.5098
Loa Loa (eye worm) RasGEF domain-containing protein 0.0051 0.0247 0.0247
Toxoplasma gondii cyclic nucleotide-binding domain-containing protein 0.0031 0.012 0.1399
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0054 0.027 0.0768
Loa Loa (eye worm) nuclear factor I 0.0056 0.0278 0.0278
Schistosoma mansoni ras GTP exchange factor 0.0051 0.0247 0.0362
Loa Loa (eye worm) CXXC zinc finger family protein 0.0076 0.0411 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Toxoplasma gondii protein kinase G AGC kinase family member PKG 0.0031 0.012 0.1399
Schistosoma mansoni camp-dependent protein kinase type I-beta regulatory subunit 0.0031 0.012 0.0176
Echinococcus multilocularis thioredoxin glutathione reductase 0.0035 0.0142 0.0186
Onchocerca volvulus 0.0086 0.0478 0.0493
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0491 0.3107 0.4063
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Echinococcus granulosus cGMP dependent protein kinase 0.0031 0.012 0.0247
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0029 0.0259
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0491 0.3107 0.3107
Loa Loa (eye worm) TAR-binding protein 0.0453 0.286 0.286
Echinococcus granulosus Protein son of sevenless 0.0051 0.0247 0.051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0021
Brugia malayi TAR-binding protein 0.0453 0.286 0.286
Trichomonas vaginalis ras GTP exchange factor, putative 0.0017 0.0027 0.0231
Mycobacterium ulcerans polyketide synthase Pks13 0.0077 0.0414 0.8653
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0027 0.0231
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0051 0.0247 0.051
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0079 0.0431 0.1227
Mycobacterium ulcerans fatty acid synthase Fas 0.0016 0.0021 0.0439
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0089
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Brugia malayi hypothetical protein 0.0071 0.0379 0.0379
Trichomonas vaginalis DNA helicase recq, putative 0.0056 0.0281 0.5726
Brugia malayi Calcitonin receptor-like protein seb-1 0.1553 1 1
Trichomonas vaginalis DNA helicase recq, putative 0.0037 0.0155 0.3001
Loa Loa (eye worm) hypothetical protein 0.0164 0.098 0.098
Chlamydia trachomatis cAMP-dependent protein kinase regulatory subunit 0.0031 0.012 0.2755
Schistosoma mansoni voltage-gated potassium channel 0.0031 0.012 0.0176
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0016 0.002 0.0471
Echinococcus granulosus tar DNA binding protein 0.0453 0.286 0.5912
Leishmania major hypothetical protein, conserved 0.0031 0.012 0.0492
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0031 0.012 0.0247
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0039 0.0052
Leishmania major hypothetical protein, conserved 0.0015 0.0017 0.0069
Loa Loa (eye worm) RecQ helicase 0.0056 0.0281 0.0281
Echinococcus granulosus voltage gated potassium channel 0.0031 0.012 0.0247
Schistosoma mansoni isocitrate dehydrogenase 0.0016 0.002 0.003
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Mycobacterium ulcerans hypothetical protein 0.0086 0.0478 1
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0017 0.0027 0.004
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0029 0.0259
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0491 0.3107 0.4063
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0016 0.0018 0.0073
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0002
Onchocerca volvulus 0.0076 0.0411 0.0422
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.0139 0.0139
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0051 0.0247 0.3393
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0132 0.0772 0.1134
Mycobacterium tuberculosis Probable lipase LipE 0.0086 0.0478 0.1363
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0032 0.0122 0.016
Schistosoma mansoni smad1 5 8 and 0.0101 0.057 0.0837
Trichomonas vaginalis penicillin-binding protein, putative 0.0086 0.0478 1
Schistosoma mansoni alpha-glucosidase 0.0103 0.0585 0.0859
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0088 0.0488 0.1391
Echinococcus granulosus Glycosyl transferase family 8 0.0051 0.0249 0.0515
Echinococcus granulosus hyperpolarization activated cyclic 0.0031 0.012 0.0247
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0132 0.0772 0.101
Echinococcus multilocularis JmjC domain containing protein 4 0.0034 0.0139 0.0181
Toxoplasma gondii thioredoxin reductase 0.0035 0.0142 0.1661
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0162 0.0966 0.1419
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0017 0.0027 0.0147
Trichomonas vaginalis ras GTP exchange factor, son of sevenless, putative 0.0017 0.0027 0.0231
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0018 0.0031 0.0086
Entamoeba histolytica hypothetical protein 0.0017 0.0027 0.0147
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0031 0.012 0.2229
Trichomonas vaginalis penicillin-binding protein, putative 0.0086 0.0478 1
Plasmodium vivax CAMP-dependent protein kinase regulatory subunit, putative 0.0031 0.012 0.1548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0046 0.0212 0.0872

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 6940 nM Binding affinity at NET ChEMBL. 18805691
Activity (binding) > 10000 nM Binding affinity at SERT ChEMBL. 18805691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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