Detailed view for TcCLB.510437.40

Basic information

TDR Targets ID: 31591
Trypanosoma cruzi, cytosolic malate dehydrogenase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 6.7065 | Length (AA): 332 | MW (Da): 35509 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG4

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00056   lactate/malate dehydrogenase, NAD binding domain
PF02866   lactate/malate dehydrogenase, alpha/beta C-terminal domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016616   oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor  
GO:0005488   binding  
GO:0003824   catalytic activity  
GO:0030060   L-malate dehydrogenase activity  
GO:0016615   malate dehydrogenase activity  
GO:0016491   oxidoreductase activity  
GO:0008152   metabolic process  
GO:0006108   malate metabolic process  
GO:0006096   glycolysis  
GO:0005975   carbohydrate metabolic process  
GO:0055114   oxidation reduction  
GO:0044262   cellular carbohydrate metabolic process  
GO:0019752   carboxylic acid metabolic process  

Structural information

Modbase 3D models:

There are 7 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 330 1civ (A) 36 365 41.00 0 1 1.51 -1.44
4 332 1y7t (A) 0 331 49.00 0 1 1.73 -1.58
5 330 5mdh (A) 1 329 48.00 0 1 1.58 -1.61
5 332 1bdm (A) 1 331 47.00 0 1 1.59295 -0.85
6 332 4tvo (A) 5 329 47.00 0 1 1.65494 -1.2
6 327 4h7p (A) 2 322 59.00 0 1 1.72028 -0.96
9 330 1civ (A) 44 365 42.00 0 1 1.57028 -1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_127410)

Species Accession Gene Product
Arabidopsis thaliana AT5G56720   malate dehydrogenase
Arabidopsis thaliana AT5G43330   malate dehydrogenase
Arabidopsis thaliana AT1G04410   malate dehydrogenase
Arabidopsis thaliana AT5G58330   lactate/malate dehydrogenase family protein
Brugia malayi Bm1_04060   Malate dehydrogenase, cytoplasmic
Caenorhabditis elegans CELE_F46E10.10   Protein MDH-1, isoform C
Chlamydia trachomatis CT_376   malate dehydrogenase
Dictyostelium discoideum DDB_G0292600   malate dehydrogenase
Dictyostelium discoideum DDB_G0280255   malate dehydrogenase
Dictyostelium discoideum DDB_G0290207   malate dehydrogenase
Drosophila melanogaster Dmel_CG5362   Malate dehydrogenase 1
Echinococcus granulosus EgrG_000517200   cytosolic malate dehydrogenase
Echinococcus granulosus EgrG_000417100   cytosolic malate dehydrogenase
Entamoeba histolytica EHI_152670   malate dehydrogenase, putative
Entamoeba histolytica EHI_030810   malate dehydrogenase,cytoplasmic, putative
Echinococcus multilocularis EmuJ_000417100   cytosolic malate dehydrogenase
Echinococcus multilocularis EmuJ_000517200   cytosolic malate dehydrogenase
Giardia lamblia GL50803_3331   Malate dehydrogenase
Homo sapiens ENSG00000014641   malate dehydrogenase 1, NAD (soluble)
Leishmania braziliensis LbrM.28.3070   cytosolic malate dehydrogenase
Leishmania donovani LdBPK_283090.1   cytosolic malate dehydrogenase
Leishmania infantum LinJ.28.3090   cytosolic malate dehydrogenase
Leishmania major LmjF.28.2860   cytosolic malate dehydrogenase
Leishmania mexicana LmxM.28.2860   cytosolic malate dehydrogenase, putative
Loa Loa (eye worm) LOAG_10359   malate dehydrogenase
Mycobacterium leprae ML1091   PROBABLE MALATE DEHYDROGENASE MDH
Mus musculus ENSMUSG00000020321   malate dehydrogenase 1, NAD (soluble)
Mycobacterium tuberculosis Rv1240   Probable malate dehydrogenase Mdh
Mycobacterium ulcerans MUL_4504   malate dehydrogenase
Oryza sativa 4346332   Os08g0562100
Oryza sativa 4336595   Os04g0551200
Oryza sativa 4348905   Os10g0478200
Saccharomyces cerevisiae YDL078C   malate dehydrogenase MDH3
Schistosoma japonicum Sjp_0207460   ko:K00026 malate dehydrogenase [EC1.1.1.37B], putative
Schistosoma mansoni Smp_035270.2   malate dehydrogenase
Schistosoma mansoni Smp_035270.1   malate dehydrogenase
Schmidtea mediterranea mk4.005559.00   Malate dehydrogenase, cytoplasmic
Schmidtea mediterranea mk4.006476.01   Malate dehydrogenase, cytoplasmic
Schmidtea mediterranea mk4.006476.02   Malate dehydrogenase
Schmidtea mediterranea mk4.000588.01   Malate dehydrogenase, cytoplasmic
Schmidtea mediterranea mk4.006476.00  
Trypanosoma brucei gambiense Tbg972.11.12570   cytosolic malate dehydrogenase, putative
Trypanosoma brucei Tb927.11.11250   cytosolic malate dehydrogenase
Trypanosoma congolense TcIL3000.11.11900   cytosolic malate dehydrogenase
Trypanosoma cruzi TcCLB.506937.10   cytosolic malate dehydrogenase, putative
Trypanosoma cruzi TcCLB.510437.40   cytosolic malate dehydrogenase, putative
Trichomonas vaginalis TVAG_381310   malate and lactate dehydrogenase, putative
Trichomonas vaginalis TVAG_171100   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_133920   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_193000   malate and lactate dehydrogenase, putative
Trichomonas vaginalis TVAG_239990   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_171090   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_253650   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_387970   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_371320   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_534540   malate and lactate dehydrogenase, putative
Trichomonas vaginalis TVAG_362930   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_455680   malate and lactate dehydrogenase, putative
Trichomonas vaginalis TVAG_354940   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_165030   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_204360   malate dehydrogenase, putative
Trichomonas vaginalis TVAG_495880   malate dehydrogenase, putative

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.6

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Thermus thermophilus Malate dehydrogenase Compounds References
Sus scrofa Malate dehydrogenase cytoplasmic Compounds References
Homo sapiens malate dehydrogenase 1, NAD (soluble) Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0111 0.4349 1
0.0758 0.9253 1
0.0105 0.3654 1
0.0746 0.7845 1
0.0116 0.66 1
0.0225 0.3313 0.3313
0.0262 0.3323 1
0.0956 0.5936 1
0.014 0.2529 0.5
0.0522 0.3748 1
0.0223 0.3042 0.5
0.0299 0.3207 1
0.054 0.3879 1
0.0448 0.5958 1
0.016 0.3341 0.5
0.0125 0.2988 0.3323
0.0829 0.8334 1
0.0094 0.8878 1
0.015 0.3235 0.3162
0.0109 0.3633 0.5
0.0810961 0.409177 0.985846
0.0796 0.4179 1
0.0907 0.5235 1
0.0292 0.3106 0.308
0.0335 0.4171 1
0.0043 0.2775 1
0.0322 0.9244 1
0.0351 0.4266 1
0.0072 0.2592 0.5
0.0251 0.2947 1
0.0232 0.3813 1
0.0094 0.8878 1
0.0857 0.5691 1
0.0933 0.4235 1
0.0422 0.8447 1
0.0094 0.8878 1
0.0189 0.8878 1
0.0507 0.9352 1
0.0116 0.5582 1
0.057 0.8878 1
0.0527 0.4359 1
0.0116 0.5582 1
0.0385 0.2994 1
0.1319 0.7343 1
0.0316 0.3553 1
0.0418 0.8594 1
0.0094 0.8878 1
0.1132 0.7455 1
0.0225 0.3313 0.3313
0.0907 0.5235 1
0.0259 0.8878 1
0.0807526 0.45147 0.989223
0.0189 0.3717 0
0.0255 0.3105 0.3101
0.0116 0.5582 1
0.0116 0.5582 1
0.0215 0.2525 0.5
0.0094 0.8878 1
0.0091 0.8878 1
0.0134 0.3565 1
0.1083 0.5238 1
0.0733 0.3844 1
0.0358 0.3084 1
0.0536 0.8565 1
0.0354 0.415 1
0.0333 0.4171 1
0.0094 0.8878 1
0.1473 0.554 1
0.07 0.5391 1
0.1628 0.5993 1
0.0225 0.3313 0.3313
0.052 0.3345 1
0.0222 0.3264 0.3264
0.0094 0.8878 1
0.0095 0.4349 0.4308
0.0584 0.8626 1
0.1275 0.5381 1
0.0094 0.8878 1
0.0279 0.2963 0.4343
0.0292 0.2955 0.2955
0.022 0.3482 0.0578
0.0662 0.8858 1
0.0094 0.8878 1
0.0297 0.4209 1
0.0109 0.3162 1
0.0134 0.3565 1
0.0272 0.3269 1
0.0522 0.3748 1
0.0116 0.5582 1
0.0595 0.4333 1
0.1132 0.7455 1
0.0094 0.8878 1
0.0109 0.3162 1
0.1057 0.7956 1
0.0829 0.8334 1
0.0567 0.379 1
0.0094 0.8878 1
0.0094 0.8878 1
0.0746 0.7845 1
0.0094 0.8878 1
0.0234 0.3314 1
0.0753 0.7169 1
0.0807526 0.45147 0.989223
0.0232 0.3813 1
0.0246 0.3856 1
0.0647 0.4844 1
0.0506 0.9375 1
0.0516 0.6349 1
0.0322 0.9244 1
0.0111 0.2548 0.4797
0.0237 0.8878 1
0.0094 0.8878 1
0.1319 0.7343 1
0.0383 0.2999 1
0.0225 0.3313 0.3313
0.0439 0.7721 1
0.0094 0.8878 1
0.0191 0.5519 1
0.0307 0.3846 1
0.0094 0.8878 1
0.0536 0.8565 1
0.016 0.3265 1
0.022 0.3482 0.0578
0.1428 0.7216 1
0.0109 0.5582 1
0.0094 0.8878 1
0.0116 0.5582 1
0.0567 0.379 1
0.1911 0.6071 1
0.0094 0.8878 1
0.0279 0.2965 0.0428
0.0094 0.8878 1
0.0854 0.4533 1
0.0094 0.8878 1
0.0064 0.4089 1
0.0392 0.3007 1
0.0547 0.4589 1
0.0527 0.4359 1
0.0039 1 1
0.0094 0.8878 1
0.0232 0.3813 1
0.0753 0.4354 1
0.019 0.2816 0.5
0.0264 0.2902 0.2902
0.0196 0.2947 0.5
0.0094 0.8878 1
0.0177 0.4156 0
0.0257 0.3332 1
0.0285 0.2784 0.0434
0.0094 0.8878 1
0.0853 0.5703 1
0.0255 0.3105 0.3101
0.0116 0.2882 0.5902
0.064 0.7508 1
0.0292 0.3204 1
0.0274 0.8156 1
0.0507 0.8878 1
0.0094 0.8878 1
0.0052 0.2847 1
0.0094 0.8878 1
0.0116 0.5582 1
0.0418 0.8594 1
0.0732 0.5092 1
0.0094 0.8878 1
0.0185 0.3874 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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Gene identifier TcCLB.510437.40 (Trypanosoma cruzi), cytosolic malate dehydrogenase, putative
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