Detailed information for compound 1591584

Basic information

Technical information
  • TDR Targets ID: 1591584
  • Name: [2-(methyl-(phenylmethyl)amino)-2-oxoethyl] 1 H-indole-3-carboxylate
  • MW: 322.358 | Formula: C19H18N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(C(=O)COC(=O)c1c[nH]c2c1cccc2)Cc1ccccc1
  • InChi: 1S/C19H18N2O3/c1-21(12-14-7-3-2-4-8-14)18(22)13-24-19(23)16-11-20-17-10-6-5-9-15(16)17/h2-11,20H,12-13H2,1H3
  • InChiKey: XGSREWZDYQWXJT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [2-(methyl-(phenylmethyl)amino)-2-oxo-ethyl] 1H-indole-3-carboxylate
  • 1H-indole-3-carboxylic acid [2-(methyl-(phenylmethyl)amino)-2-oxoethyl] ester
  • 1H-indole-3-carboxylic acid [2-(benzyl-methyl-amino)-2-keto-ethyl] ester
  • T5572779
  • ZINC08429562

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens breast cancer 1, early onset Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AGC/AKT protein kinase 0.0009 0.0003 0.0001
Plasmodium falciparum glutathione reductase 0.0016 0.0045 0.0025
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0021 0.0024
Echinococcus granulosus aminopeptidase N 0.0014 0.0033 0.0033
Brugia malayi hypothetical protein 0.0012 0.0021 0.0019
Trypanosoma cruzi lysophospholipase, putative 0.006 0.0292 0.0395
Schistosoma mansoni hypothetical protein 0.0041 0.0186 0.0186
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0264 0.0262
Leishmania major cytochrome p450-like protein 0.003 0.0121 0.0088
Loa Loa (eye worm) AGC/PKN protein kinase 0.0009 0.0003 0.0001
Schistosoma mansoni transient receptor potential channel 4 0.0017 0.0052 0.0052
Brugia malayi F/Y-rich N-terminus family protein 0.001 0.0009 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Brugia malayi Doublecortin family protein 0.0039 0.0175 0.0173
Echinococcus granulosus cathepsin L 0.0013 0.0028 0.0028
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Entamoeba histolytica aminopeptidase, putative 0.0014 0.0033 0.003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0011 0.0018 0.0017
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Brugia malayi DKFZp564C0469 protein 0.0012 0.0021 0.0019
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0264 0.0262
Brugia malayi regulator of G-protein signaling egl-10 0.0041 0.0185 0.0183
Trichomonas vaginalis replication factor C large subunit, putative 0.0012 0.0021 0.0028
Echinococcus granulosus FTZ F1 alpha 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0263 0.026
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Echinococcus multilocularis tumor protein p63 0.0388 0.2129 0.2129
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0021 0.0074 0.0039
Echinococcus multilocularis cytosolic malate dehydrogenase 0.1319 0.7343 0.7343
Entamoeba histolytica cysteine proteinase 2 0.0013 0.0028 0.0025
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0014 0.0033 0.0032
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0098 0.0098
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0021 0.0028
Brugia malayi voltage-dependent calcium channel 0.0017 0.0052 0.005
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0218 0.0216
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0107 0.0074
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Leishmania major lysophospholipase, putative 0.006 0.0292 0.026
Loa Loa (eye worm) aminopeptidase N 0.0014 0.0033 0.0032
Echinococcus granulosus cytosolic malate dehydrogenase 0.1319 0.7343 0.7343
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0041 0.0185 0.0181
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0017 0.0052 0.0052
Echinococcus multilocularis aminopeptidase N 0.0014 0.0033 0.0033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0011 0.0018 0.0017
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0226 0.0226
Onchocerca volvulus 0.0039 0.0175 0.125
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0052 0.0052
Echinococcus granulosus biogenic amine 5HT receptor 0.0266 0.1442 0.1442
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0225 0.0223
Trichomonas vaginalis malate dehydrogenase, putative 0.0812 0.4501 0.6129
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.1319 0.7343 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0264 0.0264
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0009 0.0003 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0185 0.0251
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0122 0.0122
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0045 0.0042
Trypanosoma cruzi FHA domain containing protein, putative 0.0012 0.0021 0.0026
Schistosoma mansoni ap endonuclease 0.0021 0.0074 0.0074
Trypanosoma cruzi aminopeptidase, putative 0.0014 0.0033 0.0043
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0098 0.0065
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0021 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0018 0.0017
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0107 0.0117
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0121 0.0104
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0481 0.048
Schistosoma mansoni hypothetical protein 0.003 0.0121 0.0121
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0058
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0017 0.0052 0.005
Trypanosoma brucei lysophospholipase, putative 0.006 0.0292 0.0394
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0028
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0017 0.0052 0.0052
Echinococcus multilocularis two pore calcium channel protein 1 0.0017 0.0052 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0121 0.0104
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0045 0.0058
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Echinococcus granulosus expressed protein 0.0801 0.4441 0.4441
Trypanosoma cruzi malate dehydrogenase, putative 0.099 0.5497 0.7485
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0023 0.0084 0.0084
Plasmodium vivax malate dehydrogenase, putative 0.1794 1 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0121 0.0137
Brugia malayi Cathepsin L-like precursor 0.0026 0.0098 0.0096
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0122 0.0122
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.1319 0.7343 1
Trypanosoma cruzi cysteine proteinase, putative 0.0013 0.0028 0.0036
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0041 0.0185 0.0185
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0264 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0011 0.0018 0.0017
Echinococcus multilocularis L lactate dehydrogenase 0.0804 0.4457 0.4457
Schistosoma mansoni transient receptor potential cation channel subfamily A member 0.0342 0.1868 0.1868
Leishmania major mitochondrial malate dehydrogenase 0.1229 0.684 0.6829
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0362 0.0362
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Schistosoma mansoni atypical protein kinase C 0.0015 0.0037 0.0037
Onchocerca volvulus 0.0017 0.0051 0.0257
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0045 0.0025
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0264 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0098 0.0131
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.1229 0.684 0.9314
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0185 0.0185
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0218 0.0236
Echinococcus granulosus malate dehydrogenase 0.1229 0.684 0.684
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0011 0.0018 0.0018
Schistosoma mansoni transient receptor potential channel 0.0018 0.0056 0.0056
Loa Loa (eye worm) RGS-3 protein 0.0041 0.0185 0.0183
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0021 0.0074 0.0074
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0003 0.0001
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0052 0.0049
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0107 0.0555 0.0698
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0098 0.0131
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0011 0.0018 0.0018
Plasmodium vivax vivapain-2 0.0026 0.0098 0.0096
Echinococcus granulosus sodium leak channel non selective protein 0.0017 0.0052 0.0052
Echinococcus granulosus L lactate dehydrogenase 0.0804 0.4457 0.4457
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Echinococcus multilocularis calcium activated potassium channel 0.0018 0.0055 0.0055
Loa Loa (eye worm) ctsf protein 0.0026 0.0098 0.0096
Onchocerca volvulus 0.0026 0.0098 0.0638
Schistosoma mansoni loxhd1 0.0039 0.0175 0.0175
Trypanosoma cruzi aminopeptidase, putative 0.0014 0.0033 0.0043
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Echinococcus multilocularis serotonin receptor 0.0266 0.1442 0.1442
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0121 0.0104
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0021 0.0026
Echinococcus multilocularis cpg binding protein 0.003 0.0123 0.0123
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0013 0.0028 0.0028
Toxoplasma gondii aminopeptidase N, putative 0.0014 0.0033 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0264 0.0264
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0121 0.0137
Schistosoma mansoni acyl-protein thioesterase 12 (lysophospholipase III) 0.006 0.0292 0.0292
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.0183
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0017 0.0052 0.0068
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Brugia malayi TAR-binding protein 0.0073 0.0362 0.036
Echinococcus multilocularis short transient receptor potential channel 6 0.0018 0.0056 0.0056
Loa Loa (eye worm) cysteine protease 0.0026 0.0098 0.0096
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0932 0.5172 0.5172
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0017 0.0052 0.0052
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0028 0.0038
Brugia malayi ecdysteroid receptor 0.0011 0.0018 0.0017
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0107 0.0555 0.0698
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0098 0.0096
Trypanosoma brucei glycosomal malate dehydrogenase 0.1229 0.684 0.9314
Plasmodium vivax glutathione reductase, putative 0.0047 0.0218 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0098 0.0096
Echinococcus multilocularis lactate dehydrogenase a 0.1794 1 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.0225 0.0223
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0066
Loa Loa (eye worm) RNA binding protein 0.0073 0.0362 0.036
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0021 0.0074 0.0098
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0018 0.0018
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0014 0.0033 0.0033
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0017 0.0052 0.0052
Echinococcus granulosus cytosolic malate dehydrogenase 0.1319 0.7343 0.7343
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Echinococcus multilocularis two pore calcium channel protein 2 0.0017 0.0052 0.0052
Schistosoma mansoni two-pore calcium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) malate dehydrogenase 0.1229 0.684 0.6839
Echinococcus multilocularis replication factor c subunit 1 0.0012 0.0021 0.0021
Echinococcus multilocularis dnaJ subfamily B 0.0407 0.2232 0.2232
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0121 0.0104
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0052 0.0052
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0121 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0062 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0068
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0052 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0062 0.0023
Mycobacterium ulcerans malate dehydrogenase 0.1319 0.7343 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.0021 0.0074 1
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0052 0.0049
Mycobacterium ulcerans hypothetical protein 0.0027 0.0107 0.0117
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0068 0.0048
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0107 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Toxoplasma gondii aminopeptidase N protein 0.0014 0.0033 0.003
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0216
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0481 0.0481
Trypanosoma cruzi Aminopeptidase M1, putative 0.0014 0.0033 0.0043
Echinococcus multilocularis sodium channel protein 0.0017 0.0052 0.0052
Plasmodium falciparum cysteine proteinase falcipain 1 0.0013 0.0028 0.0008
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0017 0.0052 0.0052
Echinococcus granulosus short transient receptor potential channel 6 0.0017 0.0052 0.0052
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0052 0.0052
Brugia malayi Malate dehydrogenase, cytoplasmic 0.1319 0.7343 0.7343
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0107 0.0105
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0122 0.0119
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Plasmodium falciparum thioredoxin reductase 0.0047 0.0218 0.0197
Treponema pallidum NADH oxidase 0.0016 0.0045 0.4665
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0121 0.0137
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0052 0.0052
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0216 0.0293
Brugia malayi hypothetical protein 0.0041 0.0186 0.0184
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0096
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.1319 0.7343 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0107 0.0104
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0481 0.048
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0052 0.007
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0098 0.0095
Onchocerca volvulus 0.0029 0.0114 0.0765
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0183
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0017 0.0052 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0028 0.0025
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0216 0.0293
Mycobacterium tuberculosis Probable reductase 0.0107 0.0555 0.0698
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0011 0.0018 0.0017
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0041 0.0182 0.018
Echinococcus multilocularis ecdysone induced protein 78C 0.0011 0.0018 0.0018
Brugia malayi CHE-14 protein 0.0049 0.0226 0.0224
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.0598 0.0598
Echinococcus granulosus hypothetical protein 0.0017 0.0052 0.0052
Echinococcus granulosus L lactate dehydrogenase B chain 0.1794 1 1
Leishmania major cytosolic malate dehydrogenase 0.1319 0.7343 0.7335
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0122 0.0122
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0121 0.0104
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0052 0.0052
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0017 0.0052 0.005
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0018 0.0018
Trypanosoma brucei aminopeptidase, putative 0.0014 0.0033 0.0041
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0122
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0045
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0262 0.0262
Echinococcus multilocularis expressed protein 0.0801 0.4441 0.4441
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0052 0.0052
Mycobacterium leprae putative cytochrome p450 0.003 0.0121 0.0137
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0148 0.0148
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0017 0.0052 0.005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0011 0.0018 0.0017
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0017 0.0052 0.0052
Brugia malayi Cytochrome P450 family protein 0.003 0.0121 0.012
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0121 0.0161
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0185 0.0185
Entamoeba histolytica hypothetical protein 0.0012 0.0021 0.0018
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0347 0.0345
Onchocerca volvulus 0.0014 0.0033 0.0119
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0121 0.0104
Onchocerca volvulus 0.0012 0.0021 0.0019
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0017 0.0052 0.0052
Trichomonas vaginalis malate dehydrogenase, putative 0.099 0.5497 0.7486
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0011 0.0018 0.0018
Echinococcus granulosus lactate dehydrogenase a 0.1794 1 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0119 0.0622 0.079
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0021 0.0026
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0052 0.0052
Loa Loa (eye worm) TATA binding protein associated factor 0.0014 0.0033 0.0032
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0032
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0014 0.0033 0.0043
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0098 0.0098
Plasmodium vivax replication factor C subunit 1, putative 0.0012 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0059 0.0287 0.0285
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0183
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0107 0.0555 0.0729
Echinococcus granulosus cpg binding protein 0.003 0.0123 0.0123
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0122
Echinococcus multilocularis malate dehydrogenase 0.1229 0.684 0.684
Onchocerca volvulus 0.0057 0.0272 0.2031
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0121 0.0104
Schistosoma mansoni lipoxygenase 0.0236 0.1273 0.1273
Loa Loa (eye worm) hypothetical protein 0.0057 0.0272 0.0271
Toxoplasma gondii cathepsin CPL 0.0026 0.0098 0.0095
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0186 0.0186
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0266 0.1442 0.1441
Brugia malayi cytochrome P450 0.003 0.0121 0.012
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0216
Plasmodium vivax vivapain-2 0.0026 0.0098 0.0096
Mycobacterium ulcerans aminopeptidase N PepN 0.0014 0.0033 0.0017
Echinococcus multilocularis serotonin receptor 0.0266 0.1442 0.1442
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0028 0.0027
Echinococcus multilocularis voltage dependent calcium channel 0.0017 0.0052 0.0052
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0107 0.0117
Echinococcus granulosus lactate dehydrogenase a 0.1794 1 1
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.1319 0.7343 0.7343
Schistosoma mansoni cytochrome P450 0.003 0.0121 0.0121
Echinococcus granulosus protein kinase C gamma type 0.0049 0.0228 0.0228
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.0588 0.0585
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0107 0.0555 0.0698
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0017 0.0052 0.0052
Onchocerca volvulus 0.0014 0.0033 0.0119
Echinococcus granulosus beta-adrenergic receptor kinase 0.0042 0.0187 0.0187
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0052 0.0052
Loa Loa (eye worm) peptidase family M1 containing protein 0.0014 0.0033 0.0032
Echinococcus multilocularis serine threonine protein kinase 0.0049 0.0228 0.0228
Echinococcus granulosus transient receptor potential cation channel 0.0359 0.1966 0.1966
Schistosoma mansoni hypothetical protein 0.0075 0.0373 0.0373
Schistosoma mansoni biogenic amine (5HT) receptor 0.0266 0.1442 0.1442
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0049
Echinococcus multilocularis malate dehydrogenase 0.1229 0.684 0.684
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.1319 0.7343 1
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.1229 0.684 0.9314
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0018 0.0017
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Brugia malayi topoisomerase 0.0012 0.0021 0.0019
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0187 0.0187
Echinococcus granulosus RNA directed DNA polymerase 0.0039 0.0172 0.0172
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0185 0.0185
Echinococcus granulosus malate dehydrogenase 0.1229 0.684 0.684
Echinococcus granulosus two pore calcium channel protein 2 0.0017 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus multilocularis beta adrenergic receptor kinase 0.0042 0.0187 0.0187
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0175 0.0175
Brugia malayi PXA domain containing protein 0.0041 0.0185 0.0183
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0121 0.0088
Echinococcus multilocularis cysteine protease 0.0026 0.0098 0.0098
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0045 0.0061
Brugia malayi Peptidase family M1 containing protein 0.0014 0.0033 0.0032
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0226 0.0226
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Brugia malayi Peptidase family M1 containing protein 0.0014 0.0033 0.0032
Schistosoma mansoni malate dehydrogenase 0.1319 0.7343 0.7343
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0021 0.0074 0.0096
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Leishmania major hypothetical protein, conserved 0.0017 0.0052 0.0019
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0481 0.0653
Echinococcus multilocularis thyroid hormone receptor alpha 0.0011 0.0018 0.0018
Echinococcus granulosus expressed conserved protein 0.0106 0.0549 0.0549
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0017 0.0052 0.0052
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0218 0.0218
Brugia malayi Thioredoxin reductase 0.0047 0.0218 0.0216
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0121 0.0163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0059
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0052 0.0052
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0017 0.0052 0.0268
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0017 0.0052 0.0066
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0175 0.0154
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0083
Trypanosoma brucei Aminopeptidase M1, putative 0.0014 0.0033 0.0041
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0003 0.0003
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0226 0.0224
Echinococcus granulosus protein kinase c epsilon type 0.0016 0.0044 0.0044
Plasmodium falciparum L-lactate dehydrogenase 0.1794 1 1
Brugia malayi Cathepsin L-like precursor 0.0026 0.0098 0.0096
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Echinococcus granulosus hyperpolarization activated cyclic 0.0017 0.0052 0.0052
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0052 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0059
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0107 0.0117
Loa Loa (eye worm) CYP4Cod1 0.0048 0.0225 0.0223
Schistosoma mansoni z-protein (S1r protein) 0.0041 0.0185 0.0185
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Onchocerca volvulus 0.0027 0.0107 0.0706
Schistosoma mansoni aminopeptidase A (M01 family) 0.0014 0.0033 0.0033
Schistosoma mansoni lipoxygenase 0.0165 0.0877 0.0877
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0098 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Echinococcus multilocularis short transient receptor potential channel 6 0.0017 0.0052 0.0052
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0225 0.0223
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Echinococcus multilocularis tar DNA binding protein 0.0073 0.0362 0.0362
Loa Loa (eye worm) hypothetical protein 0.0035 0.0148 0.0146
Echinococcus granulosus replication factor c subunit 1 0.0012 0.0021 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0148 0.0148
Echinococcus granulosus Regulator of G protein signaling 20 0.0041 0.0185 0.0185
Brugia malayi Cathepsin L-like precursor 0.0026 0.0098 0.0096
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0059
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0218 0.0216
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0014 0.0033 0.0041
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0107 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0362 0.0362
Trypanosoma brucei Aminopeptidase M1, putative 0.0014 0.0033 0.0041
Schistosoma mansoni steroid hormone receptor ad4bp 0.0011 0.0018 0.0018
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0068 0.0065
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0098 0.0098
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0121 0.0137
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0062 0.0023
Schistosoma mansoni malate dehydrogenase 0.1319 0.7343 0.7343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0123
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0185 0.0185
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0175 0.0175
Plasmodium vivax lactate/malate dehydrogenase, putative 0.099 0.5497 0.5496
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0074 0.0072
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Echinococcus granulosus serine:threonine protein kinase N2 0.0009 0.0003 0.0003
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.1229 0.684 0.9314
Schistosoma mansoni voltage-dependent calcium channel 0.0017 0.0052 0.0052
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0001
Schistosoma mansoni nuclear hormone receptor 0.0011 0.0018 0.0018
Brugia malayi exodeoxyribonuclease III family protein 0.0021 0.0074 0.0072
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0481 0.37
Loa Loa (eye worm) hypothetical protein 0.0014 0.0033 0.0032
Leishmania major hypothetical protein, unknown function 0.0017 0.0052 0.0019
Plasmodium vivax lactate dehydrogenase 0.1794 1 1
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0121 0.0118
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0009 0.0003 0.0001
Trypanosoma brucei cytochrome P450, putative 0.0048 0.0225 0.0302
Schistosoma mansoni polycystin 1-related 0.0039 0.0175 0.0175
Plasmodium falciparum glutathione reductase 0.0047 0.0218 0.0197
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0017 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0045 0.0059
Echinococcus multilocularis Regulator of G protein signaling 20 0.0041 0.0185 0.0185
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0105
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0017 0.0052 0.0052
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0014 0.0033 0.0043
Echinococcus multilocularis sodium leak channel non selective protein 0.0017 0.0052 0.0052
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0045 0.0012
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0175 0.0173
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0017 0.0052 0.005
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0073 0.0362 0.036
Schistosoma mansoni kinase 0.0048 0.0223 0.0223
Loa Loa (eye worm) hypothetical protein 0.1794 1 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus granulosus cathepsin L cysteine protease 0.0013 0.0028 0.0028
Echinococcus multilocularis acyl protein thioesterase 12 0.006 0.0292 0.0292
Echinococcus granulosus slit 2 protein 0.0023 0.0084 0.0084
Echinococcus granulosus calcium activated potassium channel 0.0018 0.0055 0.0055
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0098 0.0096
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0021 0.0074 0.0053
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0098 0.0098
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0266 0.1444 0.1444
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0148 0.0146
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0039 0.0175 0.0175
Echinococcus granulosus sodium channel protein 0.0017 0.0052 0.0052
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0058
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0107 0.0117
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0121 0.0137
Echinococcus multilocularis 0.003 0.0121 0.0121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0107 0.0117
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0045 0.0025
Toxoplasma gondii hypothetical protein 0.0017 0.0052 0.0049
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0185 0.0251
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0098 0.0638
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0185 0.0185
Schistosoma mansoni cell polarity protein 0.0023 0.0084 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0098 0.0078
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0017 0.0052 0.005
Trypanosoma cruzi cysteine proteinase, putative 0.0013 0.0028 0.0036
Brugia malayi RNA binding protein 0.0073 0.0362 0.036
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0017 0.0052 0.0052
Echinococcus multilocularis slit 2 protein 0.0023 0.0084 0.0084
Echinococcus granulosus pikachurin 0.0023 0.0084 0.0084
Echinococcus granulosus cathepsin l1 0.0017 0.0051 0.0051
Toxoplasma gondii phospholipase/carboxylesterase 0.006 0.0292 0.0289
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0107 0.0117
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0017 0.0052 0.0052
Echinococcus multilocularis transient receptor potential cation channel 0.036 0.1971 0.1971
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0185 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0119 0.0622 0.079
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0017 0.0052 0.005
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0121 0.0137
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0017 0.0052 0.0052
Echinococcus multilocularis voltage gated potassium channel 0.0017 0.0052 0.0052
Leishmania major malate dehydrogenase, putative 0.1794 1 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0121 0.0104
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0266 0.1444 0.1444
Loa Loa (eye worm) ryanodine receptor 0.0017 0.0052 0.005
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0028 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0013 0.0028 0.0034
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.0183
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0009 0.0003 0.0003
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0068 0.0065
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0121 0.0104
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0017 0.0052 0.005
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0017 0.0052 0.005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0059
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0018 0.0017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0021 0.0074 0.0074
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0225 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0028
Chlamydia trachomatis lysophospholipase esterase 0.006 0.0292 0.0371
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0481 0.0653
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Schistosoma mansoni cpg binding protein 0.003 0.0123 0.0123
Toxoplasma gondii aminopeptidase n, putative 0.0014 0.0033 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0166 0.0223
Brugia malayi hypothetical protein 0.0039 0.0175 0.0173
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0052 0.0052
Onchocerca volvulus 0.0026 0.0098 0.0638
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Brugia malayi Pre-SET motif family protein 0.0206 0.1106 0.1105
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0122 0.0122
Echinococcus granulosus dnaJ subfamily B 0.0407 0.2232 0.2232
Toxoplasma gondii thioredoxin reductase 0.0047 0.0218 0.0214
Loa Loa (eye worm) hypothetical protein 0.0113 0.0588 0.0586
Brugia malayi p70 ribosomal S6 kinase beta 0.0009 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0017 0.0052 0.0052
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0107 0.0117
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0109 0.0566 0.0565
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0107 0.0084
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0011 0.0018 0.0017
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0017 0.0052 0.0052
Mycobacterium tuberculosis Probable dehydrogenase 0.0107 0.0555 0.0698
Loa Loa (eye worm) hypothetical protein 0.0075 0.0373 0.0371
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0052 0.0052
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0013 0.0028 0.0036
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0014 0.0033 0.0045
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0121 0.0137
Schistosoma mansoni cellular tumor antigen P53 0.0057 0.0272 0.0272
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0042 0.0187 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0148 0.0146
Plasmodium vivax SET domain protein, putative 0.003 0.0122 0.0121
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0042 0.0187 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0185 0.0251
Loa Loa (eye worm) hypothetical protein 0.0045 0.0206 0.0204
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0148
Schistosoma mansoni cpg binding protein 0.0029 0.0114 0.0114
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0018 0.0018
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Schistosoma mansoni topbp1 0.0012 0.0021 0.0021
Brugia malayi Transient-receptor-potential like protein 0.0017 0.0052 0.005
Loa Loa (eye worm) voltage-gated potassium channel 0.0017 0.0052 0.005
Schistosoma mansoni ryanodine receptor related 0.0017 0.0052 0.0052
Echinococcus multilocularis voltage dependent calcium channel 0.0017 0.0052 0.0052
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0059
Mycobacterium ulcerans aminopeptidase N PepN 0.0014 0.0033 0.0017
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0014 0.0033 0.0043
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0017 0.0051 0.0066
Toxoplasma gondii exonuclease III APE 0.0021 0.0074 0.007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0045 0.0012
Brugia malayi protein kinase C II. 0.0016 0.0044 0.0042
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0009 0.0003 0.0003
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0121 0.0137
Brugia malayi Pax transcription activation domain interacting protein 0.0012 0.0021 0.0019
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Brugia malayi Cathepsin L-like precursor 0.0026 0.0098 0.0096
Schistosoma mansoni voltage-gated cation channel 0.0017 0.0052 0.0052
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0014 0.0033 0.0013
Schistosoma mansoni malate dehydrogenase 0.1229 0.684 0.684
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0107 0.0105
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Echinococcus multilocularis cytosolic malate dehydrogenase 0.1319 0.7343 0.7343
Onchocerca volvulus 0.0026 0.0098 0.0638
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0016 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0045 0.0059
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0098 0.0098
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0011 0.0018 0.0018
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.1319 0.7343 1
Schistosoma mansoni DNA ligase IV 0.0012 0.0021 0.0021
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1106 0.1105
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0107 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0013 0.0028 0.0034
Loa Loa (eye worm) abnormal epIthelia family member 0.0023 0.0084 0.0083
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0362 0.0362
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0014 0.0033 0.0033
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0175 0.0175
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Schistosoma mansoni transient receptor potential channel 0.0017 0.0052 0.0052
Leishmania major malate dehydrogenase, putative 0.099 0.5497 0.5482
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0013 0.0028 0.0028
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0014 0.0033 0.0032
Toxoplasma gondii hypothetical protein 0.0017 0.0052 0.0049
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0052 0.0052
Trypanosoma cruzi cysteine protease, putative 0.0013 0.0028 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0098 0.0133
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Schistosoma mansoni RAR-like nuclear receptor 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.003 0.0122 0.0121
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0185 0.0185
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0119 0.0622 0.079
Onchocerca volvulus 0.0026 0.0098 0.0638
Leishmania major trypanothione reductase 0.0047 0.0218 0.0185
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0039 0.0172 0.0172
Schistosoma mansoni L-lactate dehydrogenase 0.099 0.5497 0.5497
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0121 0.0104
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0045 0.0044
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0011 0.0018 0.0018
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0121 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Entamoeba histolytica cysteine protease, putative 0.0026 0.0098 0.0095
Echinococcus multilocularis protein kinase c iota type 0.0015 0.0037 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0018 0.0017
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0107 0.0117
Loa Loa (eye worm) steroid hormone receptor 0.0011 0.0018 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0481 0.0481
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0011 0.0018 0.0017
Echinococcus multilocularis acyl protein thioesterase 1 0.006 0.0292 0.0292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0018 0.0018
Loa Loa (eye worm) voltage-gated potassium channel 0.0017 0.0052 0.005
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0121 0.0104
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0045 0.0061
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0017 0.0052 0.005
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0185 0.0185
Echinococcus granulosus voltage gated hydrogen channel 1 0.0017 0.0052 0.0052
Brugia malayi RNA recognition motif domain containing protein 0.0073 0.0362 0.036
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.0566 0.0565
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0052 0.0052
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0003 0.0003
Echinococcus multilocularis cathepsin L 0.0013 0.0028 0.0028
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0185 0.0185
Onchocerca volvulus 0.0026 0.0098 0.0638
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0107 0.0104
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0066
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0074 0.01
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0009 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0084 0.0083
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0266 0.1444 0.1442
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0187 0.0187
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0121 0.0137
Brugia malayi Cathepsin L-like precursor 0.0026 0.0098 0.0096
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0052 0.0052
Echinococcus multilocularis transient receptor potential cation channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Echinococcus multilocularis lactate dehydrogenase protein 0.1794 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0052 0.0052
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0121 0.0104
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.0566 0.0565
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0052 0.0052
Brugia malayi Cathepsin L-like cysteine proteinase 0.0017 0.0051 0.0049
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0021 0.0019
Echinococcus multilocularis protein patched 0.0049 0.0226 0.0226
Schistosoma mansoni serine/threonine kinase 0.0009 0.0003 0.0003
Trypanosoma brucei malate dehydrogenase-related 0.099 0.5497 0.7485
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0052 0.0052
Onchocerca volvulus 0.003 0.0122 0.0832
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Brugia malayi nuclear hormone receptor 0.0011 0.0018 0.0017
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0121 0.0104
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0011 0.0018 0.0018
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Echinococcus multilocularis protein dispatched 1 0.0055 0.0265 0.0265
Echinococcus granulosus tumor protein p63 0.0388 0.2129 0.2129
Echinococcus granulosus lactate dehydrogenase protein 0.1794 1 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0264 0.0264
Echinococcus multilocularis ankyrin repeat protein 0.0342 0.1868 0.1868
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0014 0.0033 0.0045
Brugia malayi hypothetical protein 0.0017 0.0052 0.005
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0045 0.0034
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0107 0.0105
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0185 0.0185
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0098 0.0638
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.1319 0.7343 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.001 0.001
Brugia malayi hypothetical protein 0.0014 0.0033 0.0032
Entamoeba histolytica malate dehydrogenase, putative 0.1794 1 1
Trypanosoma cruzi cytochrome P450, putative 0.0048 0.0225 0.0304
Echinococcus granulosus transient receptor potential gamma protein 0.0017 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Trypanosoma brucei polo-like protein kinase 0.0094 0.0481 0.0651
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0017 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Plasmodium falciparum lactate dehydrogenase, putative 0.099 0.5497 0.5488
Echinococcus multilocularis transient receptor potential gamma protein 0.0017 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0185 0.0251
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0011 0.0018 0.0017
Echinococcus granulosus leukotriene A 4 hydrolase 0.0266 0.1444 0.1444
Schistosoma mansoni L-lactate dehydrogenase 0.1794 1 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus granulosus GPCR family 2 0.0035 0.0148 0.0148
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0218 0.0294
Echinococcus multilocularis potassium voltage gated channel protein 0.0017 0.0052 0.0052
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0017 0.0052 0.0052
Schistosoma mansoni ap endonuclease 0.0021 0.0074 0.0074
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0011 0.0018 0.0018
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0017 0.0052 0.0052
Brugia malayi Cathepsin L-like precursor 0.0026 0.0098 0.0096
Echinococcus granulosus cathepsin l1 0.0026 0.0098 0.0098
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0017 0.0052 0.0052
Leishmania major glycosomal malate dehydrogenase 0.1229 0.684 0.6829
Giardia lamblia Kinase, PLK 0.0094 0.0481 0.0629
Schistosoma mansoni voltage-gated ion channel 0.0017 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0011 0.0018 0.0018
Plasmodium vivax vivapain-1 0.0013 0.0028 0.0027
Loa Loa (eye worm) AGC/NDR protein kinase 0.0009 0.0003 0.0001
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0121 0.0137
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0041 0.0185 0.0185
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0016 0.0044 0.0042
Echinococcus multilocularis ryanodine receptor 44f 0.0017 0.0052 0.0052
Trypanosoma brucei mitochondrial malate dehydrogenase 0.1229 0.684 0.9314
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0119 0.0622 0.0821
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0226 0.0307
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0011 0.0018 0.0018
Loa Loa (eye worm) phospholipase/Carboxylesterase 0.006 0.0292 0.029
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0052 0.0052
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0148
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0021 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0148 0.0148
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0175 0.0175
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Brugia malayi hypothetical protein 0.0012 0.0021 0.0019
Loa Loa (eye worm) hypothetical protein 0.0017 0.0051 0.0049
Plasmodium vivax vivapain-3 0.0013 0.0028 0.0027
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0011 0.0018 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0264 0.0264
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0017 0.0052 0.0268
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.0566 0.0565
Leishmania major cytochrome p450-like protein 0.003 0.0121 0.0088
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0045 0.0059
Schistosoma mansoni vesicular amine transporter 0.0017 0.0052 0.0052
Plasmodium falciparum thioredoxin reductase 0.0016 0.0045 0.0025
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.0588 0.0588
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.0262 0.0262
Brugia malayi TATA binding protein associated factor 0.0014 0.0033 0.0032
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0012
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0045 0.0044
Brugia malayi ion channel NompC 0.0017 0.0052 0.005
Entamoeba histolytica malate dehydrogenase, putative 0.1319 0.7343 0.7343
Schistosoma mansoni topbp1 0.0012 0.0021 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0121 0.0104
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0045
Trichomonas vaginalis malate dehydrogenase, putative 0.0482 0.2655 0.3615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0051 0.0068
Echinococcus granulosus protein kinase c iota type 0.0015 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0185 0.0251
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0017 0.0052 0.0052
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0121 0.0137
Brugia malayi Steroid receptor seven-up type 2 0.0011 0.0018 0.0017
Echinococcus granulosus NDR protein kinase 0.0009 0.0003 0.0003
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0362 0.0362
Brugia malayi Phospholipase/Carboxylesterase family protein 0.006 0.0292 0.029
Leishmania major malate dehydrogenase 0.1229 0.684 0.6829
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0183
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0041 0.0185 0.0251
Echinococcus multilocularis transient receptor potential cation channel 0.0018 0.0056 0.0056
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0017 0.0052 0.005
Schistosoma mansoni hypothetical protein 0.0407 0.2232 0.2232
Echinococcus multilocularis shaker cognate 0.0017 0.0052 0.0052
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0052 0.0052
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0011 0.0018 0.0017
Toxoplasma gondii lactate dehydrogenase LDH1 0.1794 1 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0098 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0121 0.0121
Echinococcus multilocularis L lactate dehydrogenase B chain 0.1794 1 1
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0121 0.0104
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Brugia malayi cathepsin L-like precursor 0.0017 0.0051 0.0049
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0185 0.0183
Wolbachia endosymbiont of Brugia malayi esterase 0.006 0.0292 0.0272
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.086 0.086
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0045 0.0025
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Echinococcus granulosus Protein kinase C brain isozyme 0.0055 0.0262 0.0262
Brugia malayi cation channel family protein 0.0017 0.0052 0.005
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0014 0.0033 0.0043
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0012 0.0021 0.0018
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0011 0.0018 0.0018
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0009 0.0003 0.0003
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0012 0.0021 0.0018
Entamoeba histolytica cysteine proteinase 1, putative 0.0013 0.0028 0.0025
Brugia malayi laminin alpha chain 0.0023 0.0084 0.0083
Loa Loa (eye worm) malate dehydrogenase 0.1319 0.7343 0.7343
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.1319 0.7343 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0009 0.0003 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0481 0.0655
Echinococcus multilocularis RNA directed DNA polymerase 0.0039 0.0172 0.0172
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0042 0.0187 0.0186
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0121 0.0137
Onchocerca volvulus Transmembrane 9 superfamily member 4 homolog 0.0038 0.0166 0.1177
Echinococcus granulosus voltage dependent calcium channel 0.0017 0.0052 0.0052
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0121 0.0137
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0121 0.0137
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.086 0.086
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0052 0.0052
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0003 0.0003
Onchocerca volvulus 0.0014 0.0033 0.0119
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0014 0.0033 0.0033
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0175 0.0175
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0028 0.0025
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0186 0.0186
Echinococcus multilocularis FTZ F1 alpha 0.0011 0.0018 0.0018
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0107 0.0117
Schistosoma mansoni acyl-protein thioesterase 12 (lysophospholipase III) 0.006 0.0292 0.0292
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0017 0.0052 0.0019
Echinococcus granulosus two pore calcium channel protein 1 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0066
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0012 0.0021 0.0028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0045 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0016 0.0044 0.0044
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0017 0.0052 0.0068
Brugia malayi Cyclic-nucleotide gated cation channel 0.0017 0.0052 0.005
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.0183
Toxoplasma gondii ATPase, AAA family protein 0.0012 0.0021 0.0018
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Brugia malayi regulator of G-protein signaling rgs-7 0.0041 0.0185 0.0183
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0107 0.0104
Entamoeba histolytica hypothetical protein 0.0041 0.0185 0.0181
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0017 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0052 0.0052
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0062 0.0023
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0012 0.0021 0.0028
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0017 0.0052 0.0066
Wolbachia endosymbiont of Brugia malayi malate dehydrogenase 0.1794 1 1
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0052 0.0052
Onchocerca volvulus 0.0039 0.0175 0.125
Echinococcus granulosus shaker cognate 0.0017 0.0052 0.0052
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0183
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0009 0.0003 0.0001
Brugia malayi steroid hormone receptor 0.0011 0.0018 0.0017
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0017 0.0052 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0121 0.0104
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0121 0.0137
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0011 0.0018 0.0017
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0098 0.0131
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0045 0.0034
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0021 0.0074 0.004
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0017 0.0052 0.005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0013 0.0028 0.0028
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0011 0.0018 0.0017
Brugia malayi A-kinase anchor protein 10, precursor 0.0041 0.0185 0.0183
Onchocerca volvulus 0.0026 0.0098 0.0638
Loa Loa (eye worm) hypothetical protein 0.0049 0.0226 0.0224
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0017 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Giardia lamblia NADH oxidase lateral transfer candidate 0.0016 0.0045 0.0034
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.002 0.0068 0.0066
Loa Loa (eye worm) hypothetical protein 0.0266 0.1442 0.1441
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Echinococcus granulosus acyl protein thioesterase 1 0.006 0.0292 0.0292
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0098 0.0131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0226 0.0226
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.0588 0.0586
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0105
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0001
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0098 0.0078
Brugia malayi nuclear receptor NHR-88 0.0011 0.0018 0.0017
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0175 0.0173
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0014 0.0033 0.0043
Echinococcus multilocularis potassium large conductance calcium activated 0.0017 0.0052 0.0052
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0017 0.0052 0.005
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.0588 0.0588
Brugia malayi Papain family cysteine protease containing protein 0.0013 0.0028 0.0027
Loa Loa (eye worm) ion channel NompC 0.0017 0.0052 0.005
Echinococcus multilocularis lactate dehydrogenase a 0.1794 1 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0017 0.0052 0.0049
Brugia malayi laminin-like protein K08C7.3 precursor 0.0023 0.0084 0.0083
Brugia malayi hypothetical protein 0.0039 0.0175 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0011 0.0018 0.0017
Echinococcus multilocularis conserved hypothetical protein 0.0017 0.0052 0.0052
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0011 0.0018 0.0018
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0012
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0481 0.0481
Brugia malayi cation channel family protein 0.0017 0.0052 0.005
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0098 0.0078
Loa Loa (eye worm) TAR-binding protein 0.0073 0.0362 0.036
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0121 0.0137
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0017 0.0052 0.005
Trypanosoma brucei trypanothione reductase 0.0047 0.0218 0.0292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0098 0.0131
Plasmodium falciparum malate dehydrogenase 0.1794 1 1
Echinococcus granulosus axis inhibition protein axin 0.0041 0.0185 0.0185
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0021 0.0074 0.0098
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0012 0.0021 0.0026
Schistosoma mansoni thyroid hormone receptor 0.0011 0.0018 0.0018
Brugia malayi hypothetical protein 0.0041 0.0185 0.0183
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0011 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0028
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0017 0.0052 0.0052
Schistosoma mansoni rab6-interacting 0.0039 0.0175 0.0175
Brugia malayi hypothetical protein 0.0014 0.0033 0.0032
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0098 0.0098
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0009 0.0003 0.0001
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0216
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0017 0.0052 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Echinococcus multilocularis transfer RNA-Gly 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Brugia malayi Peptidase family M1 containing protein 0.0014 0.0033 0.0032
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0236 0.1273 0.1273
Schistosoma mansoni serine/threonine protein kinase 0.0009 0.0003 0.0003
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0055 0.0262 0.0262
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0121 0.0137
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0236 0.1273 0.1273
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0185 0.0185
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Echinococcus granulosus potassium large conductance calcium activated 0.0017 0.0052 0.0052
Echinococcus multilocularis serine:threonine protein kinase N2 0.0009 0.0003 0.0003
Brugia malayi Cytochrome P450 family protein 0.007 0.0347 0.0345
Echinococcus multilocularis lactate dehydrogenase a 0.1794 1 1
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0014 0.0033 0.0013
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0041 0.0185 0.0185
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0017 0.0052 0.0052
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0041 0.0185 0.0185
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0481 0.0478
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0017 0.0052 0.0052
Toxoplasma gondii malate dehydrogenase MDH 0.1794 1 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0121 0.0104
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0021 0.0074 0.007
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0183
Loa Loa (eye worm) hypothetical protein 0.0018 0.0058 0.0056
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Plasmodium vivax unspecified product 0.0013 0.0028 0.0027
Trichomonas vaginalis ap endonuclease, putative 0.0021 0.0074 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0028 0.0038
Loa Loa (eye worm) glutathione reductase 0.0047 0.0218 0.0216
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0048 0.0225 0.0279
Schistosoma mansoni hypothetical protein 0.0035 0.0148 0.0148
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0045 0.0058
Schistosoma mansoni hypothetical protein 0.0017 0.0052 0.0052
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0148 0.0148
Brugia malayi CXXC zinc finger family protein 0.0029 0.0114 0.0112
Chlamydia trachomatis malate dehydrogenase 0.1319 0.7343 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0121 0.0163
Brugia malayi glutathione reductase 0.0047 0.0218 0.0216
Schistosoma mansoni transient receptor potential channel 0.0017 0.0052 0.0052
Echinococcus multilocularis protein kinase c epsilon type 0.0016 0.0044 0.0044
Entamoeba histolytica hypothetical protein 0.0041 0.0185 0.0181
Echinococcus multilocularis regulator of G protein signaling 3 0.0041 0.0185 0.0185
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0034
Echinococcus granulosus neurogenic locus notch protein 0.0023 0.0084 0.0084
Echinococcus granulosus potassium voltage gated channel protein 0.0017 0.0052 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.03 0.03
Schistosoma mansoni 60S ribosomal protein L21 0.0017 0.0052 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0073 0.0362 0.0362
Schistosoma mansoni acyl-protein thioesterase 12 (lysophospholipase III) 0.006 0.0292 0.0292
Echinococcus multilocularis regulator of G protein signaling 0.0041 0.0185 0.0185
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0021 0.0074 0.0072
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0481 0.0449
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0121 0.0104
Trypanosoma cruzi malate dehydrogenase, putative 0.1229 0.684 0.9314
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0021 0.0074 0.0072
Brugia malayi hypothetical protein 0.0122 0.0639 0.0637
Echinococcus granulosus regulator of G protein signaling 3 0.0041 0.0185 0.0185
Echinococcus multilocularis hyperpolarization activated cyclic 0.0017 0.0052 0.0052
Echinococcus granulosus transient receptor potential cation channel 0.0018 0.0056 0.0056
Toxoplasma gondii lactate dehydrogenase LDH2 0.1794 1 1
Brugia malayi Cytochrome P450 family protein 0.0048 0.0225 0.0223
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0107 0.0555 0.0698
Loa Loa (eye worm) voltage-dependent calcium channel 0.0017 0.0052 0.005
Echinococcus multilocularis axis inhibition protein axin 0.0041 0.0185 0.0185
Schistosoma mansoni serine/threonine protein kinase 0.0042 0.0187 0.0187
Brugia malayi EGF-like domain containing protein 0.0023 0.0084 0.0083
Brugia malayi photoreceptor-specific nuclear receptor 0.0011 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0017 0.0052 0.0052
Echinococcus granulosus nibrin 0.0012 0.0021 0.0021
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Schistosoma mansoni chromosome transmission fidelity factor 0.0012 0.0021 0.0021
Schistosoma mansoni calcium-activated potassium channel 0.0017 0.0052 0.0052
Echinococcus granulosus ryanodine receptor 44f 0.0017 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0185 0.0251
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0011 0.0018 0.0018
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0017 0.0052 0.005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0021 0.0074 0.0053
Echinococcus granulosus acyl protein thioesterase 12 0.006 0.0292 0.0292
Loa Loa (eye worm) voltage-gated calcium channel 0.0017 0.0052 0.005
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0373 0.0371
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Entamoeba histolytica cysteine protease, putative 0.0013 0.0028 0.0025
Echinococcus granulosus short transient receptor potential channel 6 0.0018 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0114 0.0112
Schistosoma mansoni cathepsin s 0.0009 0.0002 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0098 0.0129
Schistosoma mansoni retinoic acid receptor RXR 0.0011 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0041 0.0186 0.0183
Trichomonas vaginalis AGC family protein kinase 0.0009 0.0003 0.0004
Schistosoma mansoni slit 0.0023 0.0084 0.0084
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0148 0.0146
Echinococcus multilocularis neurogenic locus notch protein 0.0023 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0039 0.0172 0.0171
Brugia malayi Hr1 repeat family protein 0.0009 0.0003 0.0001
Schistosoma mansoni axis inhibition protein axin 0.0041 0.0185 0.0185
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0014 0.0033 0.0033
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0121 0.0163
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0023 0.0084 0.0083
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0017 0.0052 0.0052
Brugia malayi Protein kinase c protein 2 0.0047 0.0216 0.0214
Echinococcus granulosus regulator of G protein signaling 7 0.0041 0.0185 0.0185
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0045 0.0042
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0121 0.0104
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0052 0.0052
Onchocerca volvulus 0.0235 0.127 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0173
Brugia malayi hypothetical protein 0.0041 0.0185 0.0183
Leishmania major cathepsin L-like protease 0.0026 0.0098 0.0065
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0121 0.0137
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0011 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0012 0.0021 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0013 0.0028 0.0036
Loa Loa (eye worm) hypothetical protein 0.0017 0.0052 0.005
Brugia malayi Cathepsin L-like precursor 0.0017 0.0051 0.0049
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0009 0.0003 0.0003
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Echinococcus granulosus ankyrin repeat protein 0.0342 0.1868 0.1868
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.1319 0.7343 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0011 0.0018 0.0017
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0098 0.0638
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0039 0.0175 0.0173
Echinococcus granulosus TRP transient receptor potential channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) histone methyltransferase 0.001 0.001 0.0008
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0068 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Schistosoma mansoni regulator of G protein signaling 0.0041 0.0185 0.0185
Echinococcus multilocularis expressed conserved protein 0.0106 0.0549 0.0549
Echinococcus multilocularis GPCR, family 2 0.0035 0.0148 0.0148
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0098 0.0133
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0121 0.0104
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Toxoplasma gondii transporter, cation channel family protein 0.0017 0.0052 0.0049
Onchocerca volvulus 0.0026 0.0098 0.0638
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.1229 0.684 0.6839
Schistosoma mansoni laminin gamma-3 chain 0.0023 0.0084 0.0084
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0098 0.0133
Echinococcus multilocularis RUN 0.0039 0.0175 0.0175
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0012 0.0021 0.0019
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0017 0.0052 0.0052
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0068 0.0066
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0017 0.0052 0.0052
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0045 0.0034
Schistosoma mansoni malate dehydrogenase 0.1794 1 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0011 0.0018 0.0018
Brugia malayi PXA domain containing protein 0.0041 0.0185 0.0183
Schistosoma mansoni patched 1 0.0049 0.0226 0.0226
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0014 0.0033 0.0033
Loa Loa (eye worm) PXA domain-containing protein 0.0041 0.0185 0.0183
Trypanosoma brucei cytosolic malate dehydrogenase 0.1319 0.7343 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0185 0.0183
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0113 0.0113
Leishmania major cytochrome p450-like protein 0.0048 0.0225 0.0192
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0017
Echinococcus granulosus ecdysone induced protein 78C 0.0011 0.0018 0.0018
Echinococcus granulosus tar DNA binding protein 0.0073 0.0362 0.0362
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0041 0.0185 0.0183
Echinococcus granulosus transient receptor potential cation channel 0.0017 0.0052 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0098 0.0095
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0045 0.0059
Trypanosoma cruzi lysophospholipase, putative 0.006 0.0292 0.0395
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0011 0.0018 0.0018
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0017 0.0052 0.005
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0017 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0047 0.0216 0.0216
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0011 0.0018 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0122 0.0122
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0264 0.0264
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0051 0.0047
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) fibroinase 0.0026 0.0098 0.0096
Echinococcus multilocularis nibrin 0.0012 0.0021 0.0021
Loa Loa (eye worm) calcium channel 0.0017 0.0052 0.005
Brugia malayi Protein kinase domain containing protein 0.0009 0.0003 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0234 0.1265 0.1722
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0014 0.0033 0.0045
Loa Loa (eye worm) hypothetical protein 0.0018 0.0056 0.0054
Onchocerca volvulus 0.0017 0.0052 0.0268
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0027 0.0107 0.0105
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0218 0.0218
Echinococcus granulosus voltage gated potassium channel 0.0017 0.0052 0.0052
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0028 0.0025
Trichomonas vaginalis malate dehydrogenase, putative 0.1319 0.7343 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0041 0.0185 0.0183
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0186 0.0186
Brugia malayi Pre-SET motif family protein 0.003 0.0122 0.0121
Echinococcus granulosus cysteine protease 0.0013 0.0028 0.0028
Loa Loa (eye worm) cytochrome P450 0.003 0.0121 0.012
Echinococcus granulosus RUN 0.0039 0.0175 0.0175
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0045 0.0045
Schistosoma mansoni rab6-interacting 0.0039 0.0175 0.0175
Echinococcus multilocularis cysteine protease 0.0026 0.0098 0.0098
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0121 0.0137
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0011 0.0018 0.0018
Brugia malayi olfactory channel protein osm-9 0.0018 0.0056 0.0054
Schistosoma mansoni coup transcription factor 0.0011 0.0018 0.0018
Echinococcus multilocularis regulator of G protein signaling 7 0.0041 0.0185 0.0185
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0021 0.0074 0.0072
Echinococcus multilocularis serine:threonine protein kinase 38 0.0009 0.0003 0.0003
Giardia lamblia Malate dehydrogenase 0.1319 0.7343 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0017 0.0052 0.007
Echinococcus multilocularis pikachurin 0.0023 0.0084 0.0084
Schistosoma mansoni voltage-gated potassium channel 0.0017 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0012 0.0021 0.0019

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7943 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.5849 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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