Detailed information for compound 1135640

Basic information

Technical information
  • TDR Targets ID: 1135640
  • Name: methyl (1S,6R)-3-(3,4-dichlorophenyl)-6-hydro xy-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-ca rboxylate
  • MW: 342.217 | Formula: C16H17Cl2NO3
  • H donors: 1 H acceptors: 2 LogP: 2.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(C[C@@H]2N(C1[C@H](O)C2)C)c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C16H17Cl2NO3/c1-19-9-6-10(8-3-4-11(17)12(18)5-8)14(16(21)22-2)15(19)13(20)7-9/h3-5,9,13,15,20H,6-7H2,1-2H3/t9-,13+,15?/m0/s1
  • InChiKey: NJIWTVLWXIINMO-DEOINHEYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1S,6R)-3-(3,4-dichlorophenyl)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Brugia malayi beta-lactamase 0.0152 0.0134 0.0807
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0062 0.0049 0.0223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0214 0.0929
Schistosoma mansoni hypothetical protein 0.1054 0.0987 0.4496
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0072 0.0326
Toxoplasma gondii histone deacetylase HDAC3 0.0142 0.0125 0.1262
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.004 0.0239
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0008 0.0049
Echinococcus granulosus carbonic anhydrase 0.1054 0.0987 0.4496
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0118 0.0513
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0064 0.0293
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.0115 0.0108
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0011 0.0049
Schistosoma mansoni ap endonuclease 0.004 0.0028 0.0128
Toxoplasma gondii histone lysine methyltransferase SET1 0.0181 0.0162 0.164
Mycobacterium tuberculosis Conserved protein 0.0152 0.0134 0.0127
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0026 0.0112
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0007 0.0042
Schistosoma mansoni sodium/chloride dependent transporter 0.0365 0.0336 0.1529
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1767 0.1662 1
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1767 0.1662 0.757
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0011 0.0219
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0007 0.0001
Trypanosoma brucei histone deacetylase 4 0.0053 0.0041 0.0213
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0114 0.0685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0124 0.0564
Trichomonas vaginalis helicase, putative 0.0021 0.001 0.0202
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.0428 0.1858
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0152 0.0134 0.0127
Echinococcus multilocularis serotonin transporter 0.0365 0.0336 0.1458
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Loa Loa (eye worm) hypothetical protein 0.1054 0.0987 0.5939
Trypanosoma cruzi histone deacetylase 1, putative 0.0142 0.0125 0.0747
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0179
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0003 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0214 0.0975
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0041 0.0185
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.0116 0.1171
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Plasmodium falciparum thioredoxin reductase 0.0052 0.004 0.0376
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0058 0.0262
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0008 0.0036
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0014 0.0062
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.1054 0.0987 0.5939
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0064
Loa Loa (eye worm) doublecortin family protein 0.0042 0.003 0.0179
Echinococcus granulosus cpg binding protein 0.01 0.0085 0.0389
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0118 0.0538
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0008 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus multilocularis microtubule associated protein 2 0.2331 0.2195 0.9535
Plasmodium falciparum histone deacetylase 1 0.0142 0.0125 0.124
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Plasmodium vivax histone deacetylase 2, putative 0.0053 0.0041 0.3026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0116 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0003
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0084 0.0504
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.001 0.0062
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0028 0.017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0118 0.0707
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0011 0.0049
Echinococcus granulosus beta LACTamase domain containing family member 0.0152 0.0134 0.0611
Brugia malayi histone deacetylase 11 0.0053 0.0041 0.0245
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0347
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0062 0.0049 0.0295
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0064
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0116 0.0527
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0152 0.0134 0.0127
Leishmania major histone deacetylase, putative 0.0053 0.0041 0.0213
Schistosoma mansoni carbonic anhydrase-related 0.1054 0.0987 0.4496
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0022 0.0102
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0007 0.0033
Echinococcus multilocularis cysteine protease 0.0019 0.0008 0.0036
Onchocerca volvulus 0.0094 0.008 0.1631
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0214 0.0975
Echinococcus granulosus tar DNA binding protein 0.0131 0.0114 0.0519
Mycobacterium ulcerans hypothetical protein 0.0027 0.0016 0.0009
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0028 0.0259
Loa Loa (eye worm) fibroinase 0.0019 0.0008 0.0049
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Schistosoma mansoni hypothetical protein 0.0874 0.0817 0.372
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0142 0.0125 0.075
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0046 0.0274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.0047
Onchocerca volvulus 0.0019 0.0008 0.0168
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0365 0.0336 0.1529
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0028 0.0167
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.0583 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0017 0.0077
Onchocerca volvulus 0.0013 0.0002 0.0047
Brugia malayi Cathepsin L-like precursor 0.0013 0.0002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0179
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0008 0.0168
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0017 0.0074
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0062 0.0049 0.0213
Loa Loa (eye worm) hypothetical protein 0.0463 0.0428 0.2574
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0015 0.0066
Toxoplasma gondii hypothetical protein 0.0062 0.0049 0.0495
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0011 0.0049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Echinococcus granulosus histone deacetylase 7 0.0053 0.0041 0.0185
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.0118 0.4046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0096
Onchocerca volvulus Histone deacetylase 10 homolog 0.0053 0.0041 0.0833
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.0055 0.0238
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0028 0.0138
Echinococcus granulosus carbonic anhydrase 0.1054 0.0987 0.4496
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.003
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1054 0.0987 0.5939
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0041 0.0246
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.0214 0.1288
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.0138 0.0122
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0007 0.0042
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0053 0.0229
Echinococcus multilocularis sodium and chloride dependent glycine 0.0062 0.0049 0.0213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0495
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0504
Onchocerca volvulus 0.0093 0.0079 0.1608
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0062 0.0049 0.0213
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0007 0.0038
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0008 0.0049
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0007 0.0031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0028 0.2095
Entamoeba histolytica histone deacetylase, putative 0.0142 0.0125 0.4274
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0022 0.0097
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0007 0.0049
Brugia malayi hypothetical protein 0.0011 0.0001 0.0007
Loa Loa (eye worm) cysteine protease 0.0019 0.0008 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.0086 0.0072 0.0326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Schistosoma mansoni rab6-interacting 0.0042 0.003 0.0135
Brugia malayi hypothetical protein 0.0042 0.003 0.0179
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0118 0.068
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0028 0.0021
Brugia malayi steroid hormone receptor 0.0021 0.0011 0.0064
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0062
Schistosoma mansoni loxhd1 0.0042 0.003 0.0135
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.003 0.0129
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0007 0.0548
Schistosoma mansoni patched 1 0.0042 0.003 0.0139
Brugia malayi cathepsin L-like precursor 0.0013 0.0002 0.0014
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.0047
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0102
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0058 0.0262
Brugia malayi Bromodomain containing protein 0.0083 0.0069 0.0416
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0096
Onchocerca volvulus 0.0062 0.0049 0.1004
Loa Loa (eye worm) hypothetical protein 0.0066 0.0053 0.0317
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0007 0.0038
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.0179 0.3657
Onchocerca volvulus 0.0019 0.0008 0.0168
Entamoeba histolytica recQ family helicase, putative 0.001 0 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0248 0.0225 0.1027
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0028 0.0138
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.0049
Echinococcus granulosus carbonic anhydrase II 0.1767 0.1662 0.757
Trypanosoma brucei histone deacetylase 2 0.0053 0.0041 0.0213
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.003 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0971 0.0909 0.0902
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0105 0.0631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0214 0.0975
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0001 0.0017
Trypanosoma brucei carbonic anhydrase-like protein 0.1767 0.1662 1
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0008 0.028
Trypanosoma brucei histone deacetylase 3 0.0053 0.0041 0.0213
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0103 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.003 0.0129
Schistosoma mansoni DNA helicase recq5 0.0021 0.001 0.0047
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0042 0.0249
Leishmania major carbonic anhydrase-like protein 0.1767 0.1662 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.0115 0.0108
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0118 0.0538
Schistosoma mansoni histone deacetylase 0.0142 0.0125 0.0568
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0008 0.0159
Onchocerca volvulus 0.0019 0.0008 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0064
Brugia malayi intermediate filament protein 0.0058 0.0046 0.0274
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0041 0.0177
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0041 0.0217
Loa Loa (eye worm) norepinephrine transporter 0.0365 0.0336 0.2019
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0016 0.0094
Mycobacterium ulcerans TetR family transcriptional regulator 1.0583 1 1
Echinococcus granulosus geminin 0.0874 0.0817 0.372
Plasmodium falciparum amino acid transporter, putative 0.0062 0.0049 0.0471
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0011 0.0219
Brugia malayi RNA binding protein 0.0131 0.0114 0.0685
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0002 0.001
Schistosoma mansoni survival motor neuron protein 0.0094 0.008 0.0363
Loa Loa (eye worm) histone deacetylase 3 0.0142 0.0125 0.075
Echinococcus granulosus sodium and chloride dependent glycine 0.0062 0.0049 0.0223
Mycobacterium tuberculosis Probable esterase LipL 0.0152 0.0134 0.0127
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0057 0.0045 0.0268
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0008 0.0056
Loa Loa (eye worm) hypothetical protein 0.0134 0.0117 0.0702
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0059
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.0134 0.261
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0016 0.0008
Loa Loa (eye worm) ctsf protein 0.0019 0.0008 0.0049
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.0125 0.2426
Leishmania major histone deacetylase, putative 0.0053 0.0041 0.0213
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0054 0.0246
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0028 0.017
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0042 0.0249
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.0049
Echinococcus granulosus histone deacetylase 6 0.0053 0.0041 0.0185
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0009 0.0419
Schistosoma mansoni zinc finger protein 0.0026 0.0015 0.0067
Plasmodium falciparum transporter, putative 0.0062 0.0049 0.0471
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0009 0.0678
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Brugia malayi hypothetical protein 0.0011 0.0001 0.0007
Plasmodium falciparum carbonic anhydrase 0.1054 0.0987 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0028 0.0021
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0103 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi Thioredoxin reductase 0.0052 0.004 0.0239
Loa Loa (eye worm) hypothetical protein 0.0058 0.0046 0.0274
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0134 0.261
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0016 0.0534
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0015 0.0063
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.003 0.0132
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0012
Echinococcus multilocularis expressed conserved protein 0.0093 0.0078 0.0339
Echinococcus granulosus zinc finger protein 0.0026 0.0015 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0079 0.0472
Echinococcus multilocularis carbonic anhydrase 0.1054 0.0987 0.4287
Entamoeba histolytica hypothetical protein 0.0013 0.0003 0.0091
Onchocerca volvulus 0.0365 0.0336 0.6874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0064
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.001 0.0097
Echinococcus multilocularis carbonic anhydrase II 0.1767 0.1662 0.7218
Leishmania major cytochrome p450-like protein 0.0017 0.0007 0.0009
Echinococcus granulosus RUN 0.0042 0.003 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.0237
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Brugia malayi histone deacetylase 3 (HD3) 0.0142 0.0125 0.075
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0225
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0064
Echinococcus granulosus cathepsin l1 0.0019 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0007 0.0045
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0025 0.015
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0318
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0183
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0042 0.0424
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Brugia malayi hypothetical protein 0.0062 0.0049 0.0295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0016 0.0009
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0002 0.0079
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Echinococcus multilocularis carbonic anhydrase 0.1054 0.0987 0.4287
Schistosoma mansoni coup transcription factor 0.0021 0.0011 0.0049
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0026 0.0117
Echinococcus granulosus expressed conserved protein 0.0093 0.0078 0.0356
Schistosoma mansoni hypothetical protein 0.1327 0.1245 0.5673
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0003
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.0214 0.1288
Plasmodium falciparum histone deacetylase 2 0.0053 0.0041 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.0352 0.6857
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.0292 1
Trichomonas vaginalis set domain proteins, putative 0.0526 0.0488 0.9497
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.004 0.0236
Echinococcus multilocularis sodium and chloride dependent glycine 0.0062 0.0049 0.0213
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0015 0.0066
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0094
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0041 0.0189
Loa Loa (eye worm) hypothetical protein 0.0208 0.0187 0.1126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0055 0.025
Schistosoma mansoni sodium/chloride dependent transporter 0.0062 0.0049 0.0225
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0011 0.0064
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0044 0.026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0012
Treponema pallidum NADH oxidase 0.0018 0.0007 0.0208
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0011 0.0049
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.004 0.0181
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1054 0.0987 0.5939
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0041 0.0189
Echinococcus granulosus histone deacetylase 0.0053 0.0041 0.0185
Mycobacterium ulcerans transcriptional regulator 1.0583 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0007 0.0012
Onchocerca volvulus Huntingtin homolog 0.0134 0.0117 0.2391
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0041 0.0246
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0028 0.0827
Schistosoma mansoni microtubule-associated protein tau 0.2331 0.2195 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0008 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.0134 0.261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0064
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0046 0.0274
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.001 0.0199
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0062 0.0049 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni sodium/chloride dependent transporter 0.0062 0.0049 0.0223
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0034 0.0154
Mycobacterium tuberculosis Probable lipase LipE 0.0152 0.0134 0.0127
Schistosoma mansoni myst-related protein 0.0013 0.0003 0.0012
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.003 0.2205
Onchocerca volvulus 0.0019 0.0008 0.0168
Mycobacterium tuberculosis Conserved protein 0.0152 0.0134 0.0127
Echinococcus multilocularis protein dispatched 1 0.0048 0.0036 0.0157
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Brugia malayi Pre-SET motif family protein 0.0463 0.0428 0.2575
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0554 0.0514 0.3093
Mycobacterium tuberculosis Conserved protein 0.0152 0.0134 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi Cytochrome P450 family protein 0.0017 0.0007 0.0042
Toxoplasma gondii exonuclease III APE 0.004 0.0028 0.0285
Trypanosoma brucei protein kinase, putative 0.0054 0.0041 0.0217
Mycobacterium ulcerans esterase/lipase LipP 0.0152 0.0134 0.0127
Schistosoma mansoni rab6-interacting 0.0042 0.003 0.0135
Plasmodium vivax vivapain-2 0.0019 0.0008 0.0601
Plasmodium falciparum glutathione reductase 0.0052 0.004 0.0376
Loa Loa (eye worm) carbonic anhydrase 3 0.1767 0.1662 1
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0007 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0011 0.0047
Mycobacterium tuberculosis Probable hydrolase 0.0152 0.0134 0.0127
Entamoeba histolytica cysteine protease, putative 0.0019 0.0008 0.028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0007 0.0042
Brugia malayi hypothetical protein 0.0042 0.003 0.0179
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0011 0.0049
Loa Loa (eye worm) glutamate receptor 0.0016 0.0005 0.0032
Schistosoma mansoni polycystin 1-related 0.0042 0.003 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0064
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0105 0.0631
Plasmodium falciparum glutathione reductase 0.0018 0.0007 0.0049
Loa Loa (eye worm) serotonin transporter b 0.0365 0.0336 0.2019
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0041 0.018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2445 0.2302 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.001 0.0047
Schistosoma mansoni histone deacetylase 1 2 3 0.0053 0.0041 0.0185
Echinococcus multilocularis protein patched 0.0042 0.003 0.0132
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.0047
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.0115 0.0108
Echinococcus multilocularis lamin 0.0058 0.0046 0.0198
Brugia malayi hypothetical protein 0.0054 0.0042 0.0252
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0062 0.0049 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.002 0.0091
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0011 0.0049
Brugia malayi beta-lactamase family protein 0.0152 0.0134 0.0807
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.001 0.0199
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0365 0.0336 0.2019
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0021 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0214 0.0929
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0103 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0016 0.0094
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.003 0.0135
Toxoplasma gondii cathepsin CPL 0.0019 0.0008 0.0082
Leishmania major hypothetical protein, conserved 0.0152 0.0134 0.0777
Echinococcus multilocularis zinc finger protein 0.0026 0.0015 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0208 0.0187 0.1126
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.0049
Trichomonas vaginalis hypothetical protein 0.0011 0.0001 0.0022
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0116 0.0109
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.0115 0.01
Onchocerca volvulus 0.0021 0.0011 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Toxoplasma gondii histone deacetylase HDAC2 0.0142 0.0125 0.1262
Loa Loa (eye worm) glutamate receptor 0.004 0.0029 0.0172
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.001 0.0077
Echinococcus multilocularis histone deacetylase 1 0.0142 0.0125 0.0542
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0134 0.261
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0058 0.0347
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0002 0.0014
Brugia malayi N-terminal motif family protein 0.0199 0.0179 0.1074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0114 0.0685
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0041 0.0246
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0152 0.0134 0.0807
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0011 0.0049
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.0134 0.0805
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.1054 0.0987 0.5939
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Echinococcus granulosus histone deacetylase 3 0.0142 0.0125 0.0568
Onchocerca volvulus 0.0062 0.0049 0.1004
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0058 0.025
Loa Loa (eye worm) hypothetical protein 0.0199 0.0179 0.1074
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0347
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0007 0.0145
Echinococcus granulosus serotonin transporter 0.0365 0.0336 0.1529
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Echinococcus granulosus dnaJ subfamily B 0.1327 0.1245 0.5673
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0053 0.024
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1767 0.1662 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0084 0.287
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0008 0.0046
Loa Loa (eye worm) hypothetical protein 0.0365 0.0336 0.2019
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni intermediate filament proteins 0.0058 0.0046 0.0207
Echinococcus granulosus sodium and chloride dependent glycine 0.0062 0.0049 0.0223
Onchocerca volvulus 0.0062 0.0049 0.1004
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1767 0.1662 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.004 0.0172
Brugia malayi Histone deacetylase family protein 0.0053 0.0041 0.0245
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0008 0.0168
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0012
Plasmodium vivax SET domain protein, putative 0.0068 0.0055 0.4079
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.001 0.0062
Brugia malayi PHD-finger family protein 0.0031 0.002 0.012
Brugia malayi Histone deacetylase 1 0.0142 0.0125 0.075
Schistosoma mansoni histone deacetylase 0.0142 0.0125 0.0568
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0011 0.0047
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0495
Loa Loa (eye worm) RecQ helicase 0.0021 0.001 0.0062
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0008 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.003 0.0135
Loa Loa (eye worm) hypothetical protein 0.0054 0.0042 0.0252
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Leishmania major trypanothione reductase 0.0052 0.004 0.0207
Brugia malayi histone deacetylase 1 (HD1) 0.0142 0.0125 0.075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0041 0.018
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Echinococcus multilocularis dnaJ subfamily B 0.1327 0.1245 0.5409
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0053 0.0229
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0114 0.0685
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0016 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0116 0.0109
Schistosoma mansoni DNA helicase recq1 0.0021 0.001 0.0047
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0124 0.0538
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Mycobacterium leprae conserved hypothetical protein 0.0152 0.0134 0.0119
Treponema pallidum sodium- and chloride- dependent transporter 0.0365 0.0336 1
Toxoplasma gondii histone deacetylase HDAC5 0.0053 0.0041 0.0411
Loa Loa (eye worm) histone deacetylase 7A 0.0053 0.0041 0.0245
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.0116 0.0665
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0007 0.0074
Loa Loa (eye worm) histone deacetylase 11 0.0053 0.0041 0.0245
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Echinococcus multilocularis lamin dm0 0.0058 0.0046 0.0198
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0018 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0007 0.0033
Trypanosoma cruzi histone deacetylase 1, putative 0.0142 0.0125 0.0747
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.003 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.003 0.0129
Trypanosoma brucei trypanothione reductase 0.0052 0.004 0.0207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0001 0.0022
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Loa Loa (eye worm) beta-lactamase 0.0152 0.0134 0.0807
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0062
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Schistosoma mansoni cpg binding protein 0.01 0.0085 0.0389
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0041 0.0189
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0053 0.0317
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0064
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.003 0.0274
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Echinococcus multilocularis carbonic anhydrase 0.1054 0.0987 0.4287
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0049
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0062
Brugia malayi CXXC zinc finger family protein 0.0093 0.0079 0.0472
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0214 0.0975
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0007 0.0548
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0007 0.0074
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Schistosoma mansoni hypothetical protein 0.0024 0.0014 0.0062
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0064
Plasmodium vivax histone deacetylase, putative 0.0053 0.0041 0.3026
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0052 0.0312
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0037 0.0162
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0016 0.0008
Giardia lamblia Histone deacetylase 0.0142 0.0125 0.4123
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0016 0.0534
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0029
Echinococcus multilocularis histone deacetylase 7 0.0053 0.0041 0.0177
Onchocerca volvulus 0.0152 0.0134 0.2749
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.0047
Brugia malayi TAR-binding protein 0.0131 0.0114 0.0685
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.0116 0.0527
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0225
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0103 0.0095
Mycobacterium ulcerans lipase LipD 0.0152 0.0134 0.0127
Schistosoma mansoni lipoxygenase 0.0248 0.0225 0.1027
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0018 0.008
Brugia malayi Bromodomain containing protein 0.004 0.0028 0.0169
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0118 0.071
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0007 0.0001
Echinococcus granulosus lamin 0.0058 0.0046 0.0207
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0016 0.0009
Schistosoma mansoni lipoxygenase 0.0174 0.0155 0.0705
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0034
Schistosoma mansoni sodium-dependent amino acid transporter 0.0062 0.0049 0.0223
Schistosoma mansoni hypothetical protein 0.0142 0.0125 0.0569
Onchocerca volvulus 0.0042 0.003 0.0608
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Onchocerca volvulus 0.0012 0.0002 0.0031
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0118 0.071
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.0134 0.0777
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.002 0.012
Schistosoma mansoni myst-related protein 0.0013 0.0003 0.0012
Echinococcus multilocularis geminin 0.0874 0.0817 0.3546
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0054 0.0235
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0041 0.0185
Schistosoma mansoni lamin 0.0058 0.0046 0.0207
Echinococcus multilocularis histone deacetylase 8 0.0053 0.0041 0.0177
Loa Loa (eye worm) hypothetical protein 0.0053 0.0041 0.0245
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0008 0.0036
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0062 0.0049 0.0223
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0007 0.0049
Toxoplasma gondii histone deacetylase HDAC1 0.0053 0.0041 0.0411
Echinococcus granulosus bloom syndrome protein 0.0021 0.001 0.0047
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Treponema pallidum fructose-bisphosphate aldolase 0.0319 0.0292 0.8692
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.0428 0.1949
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0041 0.0217
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.0055 0.0554
Echinococcus multilocularis cysteine protease 0.0019 0.0008 0.0036
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1767 0.1662 0.757
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Loa Loa (eye worm) glutathione reductase 0.0052 0.004 0.0239
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0152 0.0134 0.0127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0016 0.0534
Brugia malayi glutathione reductase 0.0052 0.004 0.0239
Schistosoma mansoni carbonic anhydrase 0.1054 0.0987 0.4496
Leishmania major histone deacetylase, putative 0.0142 0.0125 0.072
Mycobacterium ulcerans AcrR family transcriptional regulator 1.0583 1 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.008 0.0479
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.001 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0016 0.0094
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Onchocerca volvulus 0.0526 0.0488 1
Schistosoma mansoni hypothetical protein 0.0874 0.0817 0.372
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0 0.0001
Schistosoma mansoni cpg binding protein 0.0093 0.0079 0.0358
Toxoplasma gondii hypothetical protein 0.1054 0.0987 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0085 0.0388
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Loa Loa (eye worm) hypothetical protein 0.0134 0.0117 0.0702
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni bromodomain containing protein 0.0071 0.0058 0.0262
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0118 0.068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0046 0.0274
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0032
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0016 0.0009
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.003 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0028 0.0123
Echinococcus granulosus histone deacetylase 6 0.0053 0.0041 0.0185
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.004 0.0032
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Echinococcus granulosus histone deacetylase 8 0.0053 0.0041 0.0185
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0463 0.0428 0.2575
Onchocerca volvulus 0.0019 0.0008 0.0168
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0152 0.0134 0.0127
Brugia malayi nuclear receptor NHR-88 0.0021 0.0011 0.0064
Brugia malayi Histone deacetylase family protein 0.0053 0.0041 0.0245
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0011 0.0049
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0028 0.0967
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0011 0.0049
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.001 0.0047
Brugia malayi beta-lactamase family protein 0.0152 0.0134 0.0807
Brugia malayi CHE-14 protein 0.0042 0.003 0.0183
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0042 0.0399
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0094
Trichomonas vaginalis esterase, putative 0.0152 0.0134 0.261
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0007 0.0033
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0041 0.0177
Onchocerca volvulus 0.0019 0.0008 0.0168
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0318
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0248 0.0225 0.0979
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.001 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0002 0.0045
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0016 0.0009
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0011 0.0049
Brugia malayi Calcitonin receptor-like protein seb-1 0.0208 0.0187 0.1126
Echinococcus granulosus histone deacetylase 1 0.0142 0.0125 0.0568
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0011 0.0064
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Echinococcus granulosus Protein patched homolog 1 0.0042 0.003 0.0139
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0011 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0016 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0016 0.0009
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0086 0.0072 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.0134 0.0611
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.0055 0.025
Schistosoma mansoni hypothetical protein 0.0042 0.003 0.0135
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.0049
Echinococcus granulosus microtubule associated protein 2 0.2331 0.2195 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0051 0.023
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0008 0.0037
Echinococcus granulosus lamin dm0 0.0058 0.0046 0.0207
Onchocerca volvulus 0.0042 0.003 0.0608
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0116 0.0527
Brugia malayi Doublecortin family protein 0.0042 0.003 0.0179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.0292 1
Loa Loa (eye worm) histone deacetylase 1 0.0142 0.0125 0.075
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.0125 0.2426
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0011 0.0049
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0007 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0011 0.0049
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0094
Toxoplasma gondii thioredoxin reductase 0.0052 0.004 0.0401
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0072 0.0326
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0365 0.0336 0.2019
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0042 0.0399
Onchocerca volvulus 0.0019 0.0008 0.0168
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0008 0.0037
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0018 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0152 0.0134 0.0127
Brugia malayi nuclear hormone receptor 0.0021 0.0011 0.0064
Brugia malayi nuclear receptor RXR 0.0011 0.0001 0.0007
Mycobacterium tuberculosis Probable reductase 0.0119 0.0103 0.0095
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0014 0.0059
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0003 0.0018
Schistosoma mansoni cpg binding protein 0.01 0.0085 0.0389
Echinococcus granulosus cathepsin l1 0.0013 0.0002 0.001
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0118 0.0707
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0011 0.0047
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.0352 0.6857
Plasmodium vivax amine transporter, putative 0.0062 0.0049 0.3645
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0 0.0001
Loa Loa (eye worm) histone deacetylase 0.0053 0.0041 0.0245
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.0047
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Echinococcus multilocularis cpg binding protein 0.01 0.0085 0.0371
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0008 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0152 0.0134 0.0807
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0001 0.0002
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0134 0.261
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0002 0.0045
Echinococcus multilocularis RUN 0.0042 0.003 0.0129
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Schistosoma mansoni carbonic anhydrase-related 0.1054 0.0987 0.4496
Trypanosoma brucei histone deacetylase, putative 0.0053 0.0041 0.0213
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0041 0.1194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0028 0.0167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.0134 0.0611
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Brugia malayi Cytochrome P450 family protein 0.0017 0.0007 0.0042
Echinococcus multilocularis histone deacetylase 0.0053 0.0041 0.0177
Brugia malayi hypothetical protein 0.0463 0.0428 0.2574
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1054 0.0987 0.5939
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0084 0.0364
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0011 0.0064
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0009 0.0002
Plasmodium vivax glutathione reductase, putative 0.0052 0.004 0.295
Onchocerca volvulus 0.0152 0.0134 0.2749
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0114 0.0495
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0365 0.0336 0.2019
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0064
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0001 0.0005
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0011 0.0049
Onchocerca volvulus 0.0027 0.0016 0.0319
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0318
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0053 0.0317
Schistosoma mansoni carbonic anhydrase-related 0.1054 0.0987 0.4496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Toxoplasma gondii hypothetical protein 0.0062 0.0049 0.0495
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0011 0.0064
Brugia malayi MH2 domain containing protein 0.0121 0.0105 0.0631
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0053 0.024
Onchocerca volvulus 0.0152 0.0134 0.2749
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0064
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.0125 0.2426
Toxoplasma gondii ABC1 family protein 0.0152 0.0134 0.1358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0016 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0041 0.0185
Leishmania major histone deacetylase, putative 0.0142 0.0125 0.072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0214 0.0975
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0001 0.0005
Echinococcus multilocularis histone deacetylase 3 0.0142 0.0125 0.0542
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0016 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.003 0.0592
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Schistosoma mansoni ap endonuclease 0.004 0.0028 0.0128
Loa Loa (eye worm) histone methyltransferase 0.0031 0.002 0.012
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1767 0.1662 1
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.001 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0007 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0064
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.001 0.0044
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Mycobacterium ulcerans beta-lactamase 0.0152 0.0134 0.0127
Schistosoma mansoni hypothetical protein 0.0094 0.008 0.0363
Schistosoma mansoni SET domain protein 0.0012 0.0002 0.0007
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0007 0.0145
Plasmodium vivax histone deacetylase, putative 0.0053 0.0041 0.3026
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0022
Brugia malayi Receptor family ligand binding region containing protein 0.001 0 0.0001
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0029 0.0172
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0041 0.0249
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0037 0.017
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0064
Brugia malayi hypothetical protein 0.0134 0.0117 0.0702
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0008 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0028 0.0128
Brugia malayi ecdysteroid receptor 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0102
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1767 0.1662 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Echinococcus granulosus GPCR family 2 0.0066 0.0053 0.024
Mycobacterium ulcerans hypothetical protein 0.0152 0.0134 0.0127
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0008 0.0056
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Onchocerca volvulus 0.0058 0.0046 0.0932
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0183
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1054 0.0987 0.5939
Brugia malayi SET domain containing protein 0.0012 0.0002 0.0009
Entamoeba histolytica recQ family helicase, putative 0.0021 0.001 0.0351
Plasmodium vivax vivapain-2 0.0019 0.0008 0.0601
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0008 0.0037
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Plasmodium vivax hypothetical protein, conserved 0.0152 0.0134 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0072 0.0431
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.002 0.012
Mycobacterium leprae Probable lipase LipE 0.0152 0.0134 0.0119
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0016 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0041 0.0217
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0008 0.028
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.0138 0.0131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0011 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.0202
Echinococcus granulosus intermediate filament protein 0.0058 0.0046 0.0207
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0008 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0007 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.0125 0.0751
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0015 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0064
Plasmodium falciparum thioredoxin reductase 0.0018 0.0007 0.0049
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0011 0.0219
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.0049
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0064
Schistosoma mansoni hypothetical protein 0.0071 0.0058 0.0262
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0062 0.0049 0.0213
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0495
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0015 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0062 0.0049 0.0223
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0008 0.0168
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0022 0.0102
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.0116 0.0502
Brugia malayi MAP kinase sur-1 0.0054 0.0041 0.0249
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0001 0.0004
Brugia malayi Pre-SET motif family protein 0.0068 0.0055 0.033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0001 0.0007
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0103 0.0095
Schistosoma mansoni mixed-lineage leukemia protein mll 0.02 0.018 0.0818
Onchocerca volvulus 0.0058 0.0046 0.0932
Loa Loa (eye worm) hypothetical protein 0.0142 0.0125 0.0751
Echinococcus multilocularis GPCR, family 2 0.0066 0.0053 0.0229
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0028 0.0549
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0053 0.0317
Brugia malayi hypothetical protein 0.0035 0.0024 0.0142
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0028 0.0549
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0064
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0011 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0152 0.0134 0.0583
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0011 0.0049
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Echinococcus granulosus carbonic anhydrase 0.1054 0.0987 0.4496
Schistosoma mansoni zinc finger protein 0.0016 0.0005 0.0025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0041 0.0246
Schistosoma mansoni lamin 0.0058 0.0046 0.0207
Echinococcus granulosus histone deacetylase 6 0.0053 0.0041 0.0185
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0041 0.0418
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0042 0.3118
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.002 0.0087
Trypanosoma brucei histone deacetylase 1 0.0142 0.0125 0.072
Brugia malayi Cathepsin L-like precursor 0.0013 0.0002 0.0014
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0041 0.0185
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0009 0.0054
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Onchocerca volvulus 0.0068 0.0055 0.1123
Plasmodium vivax histone deacetylase 1, putative 0.0142 0.0125 0.9292
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0 0.0001
Leishmania major hypothetical protein, conserved 0.0054 0.0042 0.022
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0103 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0028 0.0729
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0011 0.0049
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0001 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0062 0.0049 0.0223
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0001 0.0029
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0001 0.0005
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0007 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.004 0.295
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Plasmodium falciparum histone deacetylase, putative 0.0053 0.0041 0.0386
Brugia malayi hypothetical protein 0.0071 0.0058 0.0346
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0028 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0034
Loa Loa (eye worm) RNA binding protein 0.0131 0.0114 0.0685
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.0116 0.0108
Loa Loa (eye worm) hypothetical protein 0.0073 0.006 0.036
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0064 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Onchocerca volvulus Glucosylceramidase homolog 0.0363 0.0334 0.6841
Toxoplasma gondii histone deacetylase HDAC4 0.0053 0.0041 0.0411
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0347
Echinococcus multilocularis musashi 0.0058 0.0046 0.0198
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0011 0.0064
Onchocerca volvulus Huntingtin homolog 0.0134 0.0117 0.2391
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0208 0.0187 0.1126
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0169
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1054 0.0987 0.5939
Giardia lamblia Fructose-bisphosphate aldolase 0.0319 0.0292 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.0134 0.0805
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0554 0.0514 0.3093
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1054 0.0987 0.5939
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.0138 0.013
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0049 0.3645
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0009 0.0041
Echinococcus multilocularis bloom syndrome protein 0.0021 0.001 0.0044
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0084 0.0381
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.0049
Loa Loa (eye worm) solute carrier family 6 member 4 0.0365 0.0336 0.2019

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.37 nM Inhibition of [3H]-WIN- 35428 binding to Dopamine transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen ChEMBL. 11472216
IC50 (binding) = 5370 nM Inhibition of [3H]-citalopram binding to the serotonin transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen. ChEMBL. 11472216

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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