Detailed information for compound 114656

Basic information

Technical information
  • TDR Targets ID: 114656
  • Name: 9-chloro-2-(2,6-difluorophenyl)-[1,2,4]triazo lo[1,5-c][1,3]benzoxazin-5-one
  • MW: 333.677 | Formula: C15H6ClF2N3O2
  • H donors: 0 H acceptors: 3 LogP: 4.08 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc2c(c1)c1nc(nn1c(=O)o2)c1c(F)cccc1F
  • InChi: 1S/C15H6ClF2N3O2/c16-7-4-5-11-8(6-7)14-19-13(20-21(14)15(22)23-11)12-9(17)2-1-3-10(12)18/h1-6H
  • InChiKey: RTBSKUFQDKNUPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Furin 1 0.2571 0.2404 0.3003
Brugia malayi GH02984p 0.0037 0.0003 0.0003
Giardia lamblia Neurogenic locus Notch protein precursor 0.011 0.0071 0.0134
Schistosoma mansoni integrin alpha 0.0956 0.0873 0.0873
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.008 0.0043 0.0677
Loa Loa (eye worm) hypothetical protein 0.0691 0.0622 0.0622
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0188 0.0145 0.0145
Mycobacterium tuberculosis Possible oxidoreductase 0.014 0.01 0.2234
Loa Loa (eye worm) transcriptional regulator 0.0112 0.0073 0.0073
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Echinococcus granulosus adam 17 protease 0.0037 0.0002 0.0002
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.0027 0.0286
Plasmodium falciparum subtilisin-like protease 2 0.0465 0.0408 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.014 0.01 0.0125
Onchocerca volvulus 0.0052 0.0017 0.0244
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Brugia malayi Integrin alpha pat-2 precursor 0.0956 0.0873 0.0873
Echinococcus multilocularis c4b binding protein beta chain 0.0036 0.0001 0.0002
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.01 0.2145
Schistosoma mansoni c4b-binding protein beta chain 0.0036 0.0001 0.0001
Echinococcus multilocularis sodium:myo inositol cotransporter 0.0146 0.0106 0.0132
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0043 0.0783
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0759 0.0687 0.1126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.002 0.002
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.014 0.01 0.01
Onchocerca volvulus 0.0036 0.0001 0.0019
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Loa Loa (eye worm) hypothetical protein 0.0039 0.0004 0.0004
Toxoplasma gondii subtilisin SUB4 0.0465 0.0408 1
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0052 0.0017 0.0021
Mycobacterium tuberculosis Polyketide synthase Pks2 0.008 0.0043 0.0792
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Toxoplasma gondii subtilisin SUB11 0.0465 0.0408 1
Toxoplasma gondii subtilisin SUB6 0.0465 0.0408 1
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0759 0.0687 1
Loa Loa (eye worm) hypothetical protein 0.0294 0.0246 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Onchocerca volvulus 0.0144 0.0103 0.1527
Loa Loa (eye worm) hypothetical protein 0.0112 0.0073 0.0073
Echinococcus granulosus sodium:myo inositol cotransporter 0.0146 0.0106 0.0106
Brugia malayi Integrin beta pat-3 precursor 0.4132 0.3882 0.3882
Loa Loa (eye worm) hypothetical protein 0.0061 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0691 0.0622 0.0622
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Loa Loa (eye worm) hypothetical protein 0.0044 0.0009 0.0009
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0112 0.0073 0.0092
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0106 0.0068 0.0084
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0055 0.0019 0.0019
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0256 0.0209 0.0209
Loa Loa (eye worm) hypothetical protein 0.0058 0.0023 0.0023
Schistosoma mansoni protein kinase 0.0256 0.0209 0.0209
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0188 0.0145 0.0239
Brugia malayi Eukaryotic aspartyl protease family protein 0.0039 0.0004 0.0004
Brugia malayi ADAMTS-like protease 0.0053 0.0017 0.0017
Mycobacterium tuberculosis Conserved hypothetical protein 0.014 0.01 0.2234
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.05 0.0441 0.603
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0112 0.0073 0.0092
Echinococcus granulosus chromatin regulatory protein sir2 0.0759 0.0687 0.0687
Mycobacterium ulcerans oxidoreductase 0.014 0.01 0.2145
Brugia malayi Subtilase family protein 0.0465 0.0408 0.0408
Mycobacterium ulcerans dehydrogenase 0.014 0.01 0.2145
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Loa Loa (eye worm) sirtuin 4 0.0112 0.0073 0.0073
Loa Loa (eye worm) reprolysin 0.009 0.0052 0.0052
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0112 0.0073 0.0764
Plasmodium vivax aspartyl protease, putative 0.0039 0.0004 0.0074
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0188 0.0145 0.0145
Mycobacterium ulcerans protoporphyrinogen oxidase 0.014 0.01 0.2145
Echinococcus granulosus high affinity choline transporter 1 0.0037 0.0003 0.0003
Brugia malayi EGF-like domain containing protein 0.011 0.0071 0.0071
Onchocerca volvulus 0.0039 0.0004 0.0064
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0017 0.0027
Loa Loa (eye worm) hypothetical protein 0.0052 0.0017 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0081 0.0044 0.0717
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0465 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0127 0.0087 0.0087
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0039 0.0004 0.0004
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.002 0.002
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0099 0.0061 0.0061
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0052 0.0052
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0465 0.0408 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.0027 0.0286
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0017 0.0021
Brugia malayi Protein kinase domain containing protein 0.0098 0.006 0.006
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0052 0.0017 0.0027
Onchocerca volvulus Fatty acid synthase homolog 0.0149 0.0108 0.1599
Schistosoma mansoni chromatin regulatory protein sir2 0.0759 0.0687 0.0687
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0294 0.0246 0.288
Schistosoma mansoni apoptosis regulator bax 0.0055 0.002 0.002
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0465 0.0408 1
Mycobacterium leprae PROBABLE CONSERVED TRANSMEMBRANE PROTEIN 0.0052 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0199 0.0156 0.0156
Echinococcus multilocularis discoidin domain receptor 0.0052 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.071 0.064 0.064
Echinococcus granulosus sodium:glucose cotransporter 2 0.0146 0.0106 0.0106
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Onchocerca volvulus 0.075 0.0678 1
Echinococcus granulosus MAM 0.0098 0.006 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0013 0.0013
Echinococcus granulosus serine:threonine protein kinase N2 0.0081 0.0044 0.0044
Schistosoma mansoni serine/threonine protein kinase 0.0239 0.0194 0.0194
Echinococcus multilocularis fibrillin 1 0.0112 0.0074 0.0092
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.008 0.0043 0.0677
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Leishmania major silent information regulator 2, putative 0.0759 0.0687 1
Giardia lamblia Furin precursor putative serine protease 0.2106 0.1963 0.533
Echinococcus granulosus neuroendocrine convertase 2 0.6687 0.6304 0.6304
Loa Loa (eye worm) endoprotease bli-4 1.0587 1 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0112 0.0073 0.0073
Leishmania major UDP-galactopyranose mutase 0.014 0.01 0.0528
Brugia malayi hypothetical protein 0.0294 0.0246 0.0246
Schistosoma mansoni hypothetical protein 0.2106 0.1963 0.1963
Chlamydia trachomatis protoporphyrinogen oxidase 0.014 0.01 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0023 0.0037
Echinococcus multilocularis sodium coupled monocarboxylate transporter 1 0.0037 0.0003 0.0003
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Onchocerca volvulus 0.0036 0.0001 0.0019
Toxoplasma gondii aspartyl protease ASP1 0.0039 0.0004 0.0074
Echinococcus multilocularis C type lectin domian containing protein 0.0036 0.0001 0.0002
Schistosoma mansoni septate junction protein 0.0061 0.0025 0.0025
Toxoplasma gondii subtilisin SUB1 0.0465 0.0408 1
Schistosoma mansoni chromatin regulatory protein sir2 0.0759 0.0687 0.0687
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2571 0.2404 0.3941
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0759 0.0687 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0112 0.0073 0.0092
Plasmodium vivax NAD-dependent deacetylase, putative 0.0112 0.0073 0.177
Brugia malayi Kelch motif family protein 0.0666 0.0598 0.0598
Loa Loa (eye worm) hypothetical protein 0.0045 0.001 0.001
Echinococcus granulosus Furin 1 0.2571 0.2404 0.2404
Echinococcus granulosus solute carrier family 5 0.0146 0.0106 0.0106
Brugia malayi EGF-like domain containing protein 0.011 0.0071 0.0071
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0085 0.0048 0.0801
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2571 0.2404 0.3941
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0759 0.0687 1
Plasmodium vivax aspartyl protease, putative 0.0039 0.0004 0.0074
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0465 0.0408 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0043 0.0677
Giardia lamblia Sirtuin type 2 0.0112 0.0073 0.0139
Loa Loa (eye worm) fatty acid synthase 0.0082 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0631 0.0566 0.0566
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0038 0.0004 0.0004
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni sodium/solute symporter 0.0037 0.0003 0.0003
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0013 0.0016
Echinococcus granulosus integrin alpha ps 0.0575 0.0513 0.0513
Giardia lamblia Neurogenic locus notch-like protein 0.011 0.0071 0.0134
Echinococcus multilocularis high affinity choline transporter 1 0.0037 0.0003 0.0003
Schistosoma mansoni hypothetical protein 0.0055 0.002 0.002
Giardia lamblia High cysteine protein 0.011 0.0071 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0037 0.0002 0.0002
Echinococcus multilocularis neuroendocrine convertase 2 0.6687 0.6304 0.7876
Loa Loa (eye worm) hypothetical protein 0.0053 0.0017 0.0017
Echinococcus multilocularis protein will die slowly 0.0146 0.0106 0.0132
Brugia malayi aspartic protease BmAsp-1, identical 0.0039 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni high-affinity choline transporter 0.0037 0.0003 0.0003
Echinococcus granulosus protein will die slowly 0.0146 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0098 0.006 0.006
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0036 0.0001 0.0001
Plasmodium vivax plasmepsin V, putative 0.0441 0.0385 0.9436
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.014 0.01 0.2433
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0118 0.0079 0.0079
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0039 0.0004 0.0004
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0112 0.0073 0.0139
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0112 0.0073 0.0092
Toxoplasma gondii subtilisin SUB9 0.0465 0.0408 1
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Giardia lamblia Transcriptional regulator, Sir2 family 0.0112 0.0073 0.0139
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0107 0.0069 0.0069
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.0013 0.0016
Schistosoma mansoni chromatin regulatory protein sir2 0.0759 0.0687 0.0687
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0106 0.0068 0.0068
Schistosoma mansoni inositol transporter 0.0146 0.0106 0.0106
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0691 0.0622 0.0777
Plasmodium vivax plasmepsin IV, putative 0.0039 0.0004 0.0074
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0648 0.0581 0.0581
Schistosoma mansoni chromatin regulatory protein sir2 0.0112 0.0073 0.0073
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0112 0.0073 0.177
Trichomonas vaginalis conserved hypothetical protein 0.0465 0.0408 0.0669
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Brugia malayi transcriptional regulator, Sir2 family protein 0.0112 0.0073 0.0073
Schistosoma mansoni hypothetical protein 0.0246 0.0201 0.0201
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0465 0.0408 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Mycobacterium ulcerans NAD-dependent deacetylase 0.0112 0.0073 0.1457
Trichomonas vaginalis teneurin and N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase, putative 0.011 0.0071 0.0117
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0106 0.0068 0.163
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0188 0.0145 0.3544
Brugia malayi celfurPC protein 0.8481 0.8004 0.8004
Schistosoma mansoni discoidin domain receptor 0.0052 0.0017 0.0017
Giardia lamblia Tenascin-X 0.011 0.0071 0.0134
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0043 0.0677
Echinococcus granulosus c-Jun N-terminal kinases 0.0239 0.0194 0.0194
Plasmodium vivax hypothetical protein, conserved 0.014 0.01 0.2433
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6471 0.6099 1
Echinococcus multilocularis protein jagged 2 0.011 0.0071 0.0089
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0017 0.0375
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0059 0.0023 0.0296
Schistosoma mansoni site-1 peptidase (S08 family) 0.0465 0.0408 0.0408
Toxoplasma gondii transporter, solute:sodium symporter (SSS) family protein 0.0037 0.0003 0.0031
Schistosoma mansoni inhibitor of apoptosis protein 0.0107 0.0069 0.0069
Mycobacterium tuberculosis Probable thioesterase TesA 0.0069 0.0032 0.0523
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0013 0.0013
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0188 0.0145 0.0145
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2571 0.2404 0.3941
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0239 0.0194 0.0194
Echinococcus multilocularis sodium:glucose cotransporter 2 0.0146 0.0106 0.0132
Onchocerca volvulus 0.0036 0.0001 0.0019
Loa Loa (eye worm) hypothetical protein 0.0055 0.002 0.002
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0759 0.0687 0.0687
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0106 0.0068 0.0111
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.0027 0.0286
Onchocerca volvulus 0.0037 0.0003 0.0038
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0465 0.0408 0.051
Echinococcus multilocularis epidermal growth factor receptor 0.0653 0.0586 0.0732
Onchocerca volvulus 0.0036 0.0001 0.0019
Brugia malayi hypothetical protein 0.0118 0.0079 0.0079
Brugia malayi Carm1-pending protein 0.0106 0.0068 0.0068
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Echinococcus granulosus glutamate NMDA receptor subunit 0.0268 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0098 0.006 0.006
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0052 0.0017 0.0017
Toxoplasma gondii subtilisin SUB2 0.0465 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0052 0.0052
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0085 0.0048 0.0906
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0017 0.0375
Echinococcus multilocularis growth factor receptor bound protein 2 0.0132 0.0092 0.0115
Loa Loa (eye worm) transcriptional regulator 0.0759 0.0687 0.0687
Loa Loa (eye worm) integrin alpha pat-2 0.1283 0.1183 0.1183
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0121 0.0081 0.1761
Giardia lamblia High cysteine protein 0.011 0.0071 0.0134
Loa Loa (eye worm) hypothetical protein 0.011 0.0071 0.0071
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.008 0.0043 0.0783
Plasmodium falciparum plasmepsin III 0.0039 0.0004 0.0074
Schistosoma mansoni chromatin regulatory protein sir2 0.0112 0.0073 0.0073
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0256 0.0209 0.0262
Schistosoma mansoni site-1 peptidase (S08 family) 0.0465 0.0408 0.0408
Echinococcus granulosus sodium coupled monocarboxylate transporter 1 0.0037 0.0003 0.0003
Schistosoma mansoni glutamate receptor NMDA 0.0268 0.0221 0.0221
Schistosoma mansoni tyrosine kinase 0.0653 0.0586 0.0586
Loa Loa (eye worm) MH2 domain-containing protein 0.0133 0.0093 0.0093
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2571 0.2404 0.3941
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0042 0.0007 0.0134
Loa Loa (eye worm) WD40 repeat protein 0.0146 0.0106 0.0106
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0691 0.0622 0.0622
Entamoeba histolytica PH domain containing protein kinase, putative 0.0081 0.0044 0.0317
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2571 0.2404 0.3941
Schistosoma mansoni memapsin-2 (A01 family) 0.0039 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0003 0.0003
Onchocerca volvulus 0.0039 0.0004 0.0064
Schistosoma mansoni hypothetical protein 0.0055 0.002 0.002
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0106 0.0068 0.0084
Onchocerca volvulus 0.0036 0.0001 0.0019
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.0013 0.0013
Brugia malayi Furin-like cysteine rich region family protein 0.0653 0.0586 0.0586
Plasmodium vivax subtilisin-like serine protease, putative 0.0465 0.0408 1
Plasmodium falciparum plasmepsin IX 0.0039 0.0004 0.0074
Brugia malayi Sodium:solute symporter family protein 0.0037 0.0003 0.0003
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.002 0.0025
Loa Loa (eye worm) transcriptional regulator 0.0112 0.0073 0.0073
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0017 0.0017
Brugia malayi Sushi domain 0.0036 0.0001 0.0001
Toxoplasma gondii histone deacetylase SIR2 0.0112 0.0073 0.177
Echinococcus granulosus lysine specific histone demethylase 1A 0.014 0.01 0.01
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0465 0.0408 0.0408
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Onchocerca volvulus 0.0057 0.0021 0.0314
Brugia malayi hypothetical protein 0.0039 0.0004 0.0004
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0017 0.0375
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0013 0.0013
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.2106 0.1963 0.3218
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.008 0.0043 0.0677
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0294 0.0246 0.288
Echinococcus granulosus sodium:glucose cotransporter 0.0146 0.0106 0.0106
Onchocerca volvulus 0.0036 0.0001 0.0019
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0085 0.0048 0.0801
Loa Loa (eye worm) hypothetical protein 1.0587 1 1
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Echinococcus multilocularis disintegrin and metalloproteinase 0.0037 0.0002 0.0003
Loa Loa (eye worm) proprotein convertase 2 0.2571 0.2404 0.2404
Loa Loa (eye worm) hypothetical protein 0.075 0.0678 0.0678
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.014 0.01 0.2145
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2571 0.2404 0.2404
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0013 0.0013
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0017 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0465 0.0408 0.0669
Leishmania major sir2-family protein-like protein 0.0112 0.0073 0.0092
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0017 0.0375
Toxoplasma gondii aspartyl protease ASP5 0.0402 0.0348 0.8523
Trypanosoma brucei subtilisin peptidase 0.0465 0.0408 0.55
Loa Loa (eye worm) aspartyl protease 6 0.0039 0.0004 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0077 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0098 0.006 0.006
Toxoplasma gondii subtilisin SUB8 0.0465 0.0408 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0013 0.0013
Plasmodium falciparum plasmepsin II 0.0039 0.0004 0.0074
Echinococcus granulosus integrin beta 2 0.3054 0.2862 0.2862
Trichomonas vaginalis conserved hypothetical protein 0.0465 0.0408 0.0669
Echinococcus granulosus protein arginine methyltransferase 0.0188 0.0145 0.0145
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0107 0.0069 0.0086
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0224 0.0179 0.0179
Schistosoma mansoni btb and poz domain-containing protein 0.0052 0.0017 0.0017
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0106 0.0068 0.0111
Plasmodium falciparum plasmepsin X 0.0039 0.0004 0.0074
Brugia malayi Angiotensin-converting enzyme family protein 0.0648 0.0581 0.0581
Brugia malayi MH2 domain containing protein 0.0133 0.0093 0.0093
Brugia malayi Protein kinase domain containing protein 0.0052 0.0017 0.0017
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0465 0.0408 0.0408
Trichomonas vaginalis hypothetical protein 0.011 0.0071 0.0117
Brugia malayi NAD-dependent deacetylase SIRT1 0.0112 0.0073 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Trichomonas vaginalis conserved hypothetical protein 0.0058 0.0023 0.0037
Plasmodium falciparum subtilisin-like protease 1 0.0465 0.0408 1
Onchocerca volvulus 0.0052 0.0017 0.0244
Mycobacterium ulcerans polyketide synthase Pks13 0.0121 0.0081 0.1666
Loa Loa (eye worm) hypothetical protein 0.4116 0.3868 0.3868
Schistosoma mansoni amine oxidase 0.014 0.01 0.01
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Brugia malayi transcriptional regulator, Sir2 family protein 0.0112 0.0073 0.0073
Plasmodium falciparum plasmepsin VI 0.0039 0.0004 0.0074
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0077 0.004 0.004
Toxoplasma gondii type I fatty acid synthase, putative 0.0059 0.0023 0.0531
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0039 0.0004 0.0007
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0188 0.0145 0.3544
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0013 0.0016
Plasmodium vivax aspartyl proteinase, putative 0.0039 0.0004 0.0074
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0112 0.0073 0.0092
Echinococcus multilocularis integrin alpha 3 0.0688 0.062 0.0774
Trichomonas vaginalis hypothetical protein 0.2106 0.1963 0.3218
Schistosoma mansoni discoidin domain receptor 0.0052 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0759 0.0687 1
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0465 0.0408 0.0408
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Loa Loa (eye worm) hypothetical protein 0.0308 0.0259 0.0259
Echinococcus multilocularis adam 0.0228 0.0183 0.0228
Plasmodium falciparum subtilisin-like protease 3 0.0465 0.0408 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0465 0.0408 1
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0069 0.0032 0.0414
Schistosoma mansoni SWI/SNF complex-related 0.0058 0.0023 0.0023
Echinococcus multilocularis membrane bound transcription factor site 1 0.0465 0.0408 0.051
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.014 0.01 0.2433
Mycobacterium ulcerans monoamine oxidase 0.014 0.01 0.2145
Loa Loa (eye worm) hypothetical protein 0.0037 0.0002 0.0002
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0039 0.0004 0.0074
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0052 0.0017 0.0123
Schistosoma mansoni growth factor receptor-bound protein 0.0132 0.0092 0.0092
Schistosoma mansoni chromatin regulatory protein sir2 0.0112 0.0073 0.0073
Echinococcus granulosus adam 0.0228 0.0183 0.0183
Schistosoma mansoni serine/threonine protein kinase 0.0099 0.0061 0.0061
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0077 0.004 0.0723
Echinococcus granulosus glutamate receptor 2 0.0048 0.0013 0.0013
Schistosoma mansoni hypothetical protein 0.0055 0.002 0.002
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0188 0.0145 0.0182
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.014 0.01 0.2433
Onchocerca volvulus 0.011 0.0071 0.1052
Mycobacterium leprae Polyketide synthase Pks13 0.0121 0.0081 0.1666
Loa Loa (eye worm) hypothetical protein 0.0039 0.0004 0.0004
Brugia malayi hypothetical protein 0.014 0.01 0.01
Schistosoma mansoni protein kinase 0.0256 0.0209 0.0209
Giardia lamblia Hypothetical protein 0.0759 0.0687 0.1824
Schistosoma mansoni protein kinase 0.0256 0.0209 0.0209
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0465 0.0408 1
Toxoplasma gondii PA14 domain-containing protein 0.0052 0.0017 0.0375
Brugia malayi GCC2 and GCC3 family protein 0.0045 0.001 0.001
Loa Loa (eye worm) Carm1-pending protein 0.0106 0.0068 0.0068
Toxoplasma gondii type I fatty acid synthase, putative 0.0085 0.0048 0.1138
Schistosoma mansoni amine oxidase 0.014 0.01 0.01
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.0058 0.0023 0.0028
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0666 0.0598 0.0598
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0052 0.0017 0.0021
Schistosoma mansoni inositol transporter 0.0146 0.0106 0.0106
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0013 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0113 0.0074 0.0093
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.05 0.0441 0.603
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0188 0.0145 0.3544
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Loa Loa (eye worm) TK/ALK protein kinase 0.0098 0.006 0.006
Entamoeba histolytica hypothetical protein 0.0294 0.0246 0.3363
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.008 0.0043 0.0783
Brugia malayi hypothetical protein 0.0039 0.0004 0.0004
Onchocerca volvulus 0.0107 0.0069 0.1012
Loa Loa (eye worm) hypothetical protein 0.0053 0.0017 0.0017
Schistosoma mansoni cathepsin D (A01 family) 0.0039 0.0004 0.0004
Echinococcus granulosus C type lectin domian containing protein 0.0036 0.0001 0.0001
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0085 0.0048 0.0906
Trichomonas vaginalis hypothetical protein 0.0052 0.0017 0.0027
Echinococcus multilocularis MAM 0.0098 0.006 0.0075
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.002 0.002
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Echinococcus granulosus protein kinase c epsilon type 0.0099 0.0061 0.0061
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.2106 0.1963 0.3218
Loa Loa (eye worm) hypothetical protein 0.0465 0.0408 0.0408
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.05 0.0441 0.603
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0112 0.0073 0.1555
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.009 0.0052 0.0065
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0013 0.0016
Brugia malayi Protein arginine N-methyltransferase 0.0106 0.0068 0.0068
Echinococcus granulosus subfamily M12B unassigned peptidase 0.009 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0465 0.0408 0.0669
Toxoplasma gondii subtilisin SUB5 0.0465 0.0408 1
Brugia malayi protein kinase C II. 0.0099 0.0061 0.0061
Brugia malayi hypothetical protein 0.0631 0.0566 0.0566
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0039 0.0004 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0013 0.0013
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0107 0.0069 0.0069
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0465 0.0408 0.0408
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0465 0.0408 0.0408
Brugia malayi ADAM-TS Spacer 1 family protein 0.0053 0.0017 0.0017
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0017 0.0017
Echinococcus multilocularis integrin alpha ps 0.0575 0.0513 0.064
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0759 0.0687 1
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Echinococcus granulosus inhibitor of apoptosis protein 0.0107 0.0069 0.0069
Schistosoma mansoni hypothetical protein 0.0106 0.0068 0.0068
Echinococcus granulosus methyltransferase protein 5 0.0106 0.0068 0.0068
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.014 0.01 0.2145
Trypanosoma cruzi subtilisin peptidase 0.0465 0.0408 0.55
Schistosoma mansoni furin-1 (S08 family) 0.4582 0.4309 0.4309
Schistosoma mansoni protein arginine n-methyltransferase 0.0106 0.0068 0.0068
Echinococcus multilocularis protein kinase c epsilon type 0.0099 0.0061 0.0076
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0013 0.0013
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Schistosoma mansoni growth factor receptor-bound protein 0.0132 0.0092 0.0092
Toxoplasma gondii subtilisin SUB10 0.0465 0.0408 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0154 0.0113 0.0113
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.6471 0.6099 0.6099
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0759 0.0687 0.1126
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0052 0.0017 0.0027
Echinococcus granulosus integrin alpha ps 0.0246 0.0201 0.0201
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Echinococcus multilocularis serine:threonine protein kinase N2 0.009 0.0053 0.0066
Mycobacterium ulcerans polyketide synthase 0.008 0.0043 0.0677
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0112 0.0073 0.0073
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0076 0.0039 0.0039
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0112 0.0073 0.0764
Giardia lamblia High cysteine membrane protein Group 2 0.39 0.3663 1
Brugia malayi proprotein convertase 2 0.6687 0.6304 0.6304
Echinococcus multilocularis chromatin regulatory protein sir2 0.0759 0.0687 0.0858
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0112 0.0073 0.177
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Schistosoma mansoni integrin alpha-ps 0.0329 0.0279 0.0279
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0048 0.0906
Brugia malayi CUB domain containing protein 0.0038 0.0004 0.0004
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.01 0.0528
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.002 0.002
Plasmodium vivax protoporphyrinogen oxidase, putative 0.014 0.01 0.2433
Echinococcus multilocularis protein arginine methyltransferase 0.0188 0.0145 0.0182
Giardia lamblia Tenascin-like 0.011 0.0071 0.0134
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0013 0.0013
Mycobacterium ulcerans Type I modular polyketide synthase 0.008 0.0043 0.0677
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.014 0.01 0.2433
Echinococcus granulosus protein arginine N methyltransferase 7 0.0106 0.0068 0.0068
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.6471 0.6099 1
Schistosoma mansoni hypothetical protein 0.0052 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.011 0.0071 0.0071
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0106 0.0068 0.0678
Loa Loa (eye worm) hypothetical protein 0.011 0.0071 0.0071
Loa Loa (eye worm) TK/EGFR protein kinase 0.0653 0.0586 0.0586
Onchocerca volvulus 0.0098 0.006 0.0884
Schistosoma mansoni hypothetical protein 0.0107 0.0069 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0112 0.0073 0.0092
Brugia malayi amine oxidase, flavin-containing family protein 0.0199 0.0156 0.0156
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0132 0.0092 0.0092
Plasmodium falciparum plasmepsin V 0.0441 0.0385 0.9436
Brugia malayi SWIRM domain containing protein 0.0058 0.0023 0.0023
Schistosoma mansoni dock 0.0052 0.0017 0.0017
Echinococcus granulosus lysine specific histone demethylase 1A 0.0691 0.0622 0.0622
Echinococcus multilocularis integrin alpha ps 0.0514 0.0454 0.0568
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Toxoplasma gondii subtilisin SUB7 0.0465 0.0408 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0003 0.0003
Schistosoma mansoni cathepsin D (A01 family) 0.0039 0.0004 0.0004
Schistosoma mansoni integrin alpha-ps 0.0514 0.0454 0.0454
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Plasmodium falciparum protoporphyrinogen oxidase 0.014 0.01 0.2433
Trichomonas vaginalis conserved hypothetical protein 0.0465 0.0408 0.0669
Schistosoma mansoni hypothetical protein 0.0098 0.006 0.006
Plasmodium falciparum plasmepsin IV 0.0039 0.0004 0.0074
Loa Loa (eye worm) transcription factor SMAD2 0.0133 0.0093 0.0093
Toxoplasma gondii subtilisin SUB12 0.0465 0.0408 1
Toxoplasma gondii F5/8 type C domain-containing protein 0.0052 0.0017 0.0375
Plasmodium vivax subtilisin-like protease 2, putative 0.0465 0.0408 1
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0112 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0107 0.0069 0.0069
Loa Loa (eye worm) hypothetical protein 0.0107 0.0069 0.0069
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Echinococcus multilocularis integrin beta 2 0.3054 0.2862 0.3575
Brugia malayi Sex muscle abnormal protein 5 0.0132 0.0092 0.0092
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.3914 0.3677 0.3677
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0112 0.0073 0.0092
Echinococcus multilocularis 0.014 0.01 0.0125
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0694 0.0625 0.0781
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0037 0.0002 0.0003
Brugia malayi angiogenesis inhibito 0.0053 0.0017 0.0017
Brugia malayi Will die slowly protein 0.0146 0.0106 0.0106
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Mycobacterium ulcerans Sir2-like regulatory protein 0.0112 0.0073 0.1457
Loa Loa (eye worm) integrin beta-2 0.4132 0.3882 0.3882
Plasmodium vivax aspartyl proteinase, putative 0.0039 0.0004 0.0074
Loa Loa (eye worm) hypothetical protein 0.0442 0.0386 0.0386
Mycobacterium ulcerans polyketide synthase 0.0085 0.0048 0.0801
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Entamoeba histolytica hypothetical protein, conserved 0.0112 0.0073 0.0764
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0188 0.0145 0.0239
Giardia lamblia hypothetical protein 0.011 0.0071 0.0134
Onchocerca volvulus 0.0178 0.0136 0.2
Onchocerca volvulus 0.0036 0.0001 0.0019
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0081 0.0044 0.0823
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Mycobacterium ulcerans thioesterase 0.0069 0.0032 0.0414
Onchocerca volvulus 0.0146 0.0106 0.1564
Trypanosoma cruzi UDP-galactopyranose mutase 0.014 0.01 0.0528
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.008 0.0043 0.0043
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0039 0.0004 0.0004
Echinococcus multilocularis fibrillin 2 0.011 0.0071 0.0089
Echinococcus multilocularis solute carrier family 5 0.0146 0.0106 0.0132
Toxoplasma gondii histone deacetylase SIR2-like 0.0112 0.0073 0.177
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.008 0.0043 0.0792
Echinococcus granulosus membrane bound transcription factor site 1 0.0465 0.0408 0.0408
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0039 0.0004 0.0005
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.0058 0.0023 0.0023
Echinococcus granulosus furin 1.0587 1 1
Mycobacterium leprae Possible secreted protease 0.0465 0.0408 1
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0106 0.0068 0.0068
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.6471 0.6099 0.762
Schistosoma mansoni hypothetical protein 0.0146 0.0106 0.0106
Brugia malayi hypothetical protein 0.0098 0.006 0.006
Echinococcus granulosus growth factor receptor bound protein 2 0.0132 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0043 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2571 0.2404 0.3941
Echinococcus multilocularis integrin alpha ps 0.0246 0.0201 0.0251
Schistosoma mansoni dihydroceramide desaturase 0.0037 0.0002 0.0002
Loa Loa (eye worm) subtilase 0.0465 0.0408 0.0408
Leishmania major arginine N-methyltransferase-like protein 0.0188 0.0145 0.1258
Mycobacterium ulcerans thioesterase TesA 0.0069 0.0032 0.0414
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0759 0.0687 0.0858
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0268 0.0221 0.0276
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0294 0.0246 0.3363
Leishmania major subtilisin-like serine peptidase 0.0465 0.0408 0.55
Brugia malayi Pepsin A precursor 0.0039 0.0004 0.0004
Echinococcus multilocularis inhibitor of apoptosis protein 0.0107 0.0069 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218
Plasmodium falciparum plasmepsin I 0.0039 0.0004 0.0074
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0106 0.0068 0.163
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0081 0.0044 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Trichomonas vaginalis WD repeat domain, putative 0.0146 0.0106 0.0174
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Toxoplasma gondii hypothetical protein 0.011 0.0071 0.172
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0037 0.0002 0.0002
Onchocerca volvulus 0.0036 0.0001 0.0019
Echinococcus granulosus protein arginine N methyltransferase 8 0.0188 0.0145 0.0145
Brugia malayi Disintegrin family protein 0.0037 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.014 0.01 0.01
Plasmodium falciparum plasmepsin VIII, putative 0.0039 0.0004 0.0074
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Loa Loa (eye worm) hypothetical protein 0.0329 0.0279 0.0279
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.009 0.0052 0.0052
Plasmodium vivax aspartyl protease, putative 0.0039 0.0004 0.0074
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0085 0.0048 0.0801
Schistosoma mansoni hypothetical protein 0.0098 0.006 0.006
Echinococcus granulosus disintegrin and metalloproteinase 0.0037 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0635 0.0569 0.0569
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0188 0.0145 0.0239
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0121 0.0081 0.1761
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Onchocerca volvulus Putative cubilin 0.0044 0.0009 0.013
Echinococcus granulosus epidermal growth factor receptor 0.0653 0.0586 0.0586
Brugia malayi Calcium binding EGF domain containing protein 0.0044 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0017 0.0027
Onchocerca volvulus Deterin homolog 0.0107 0.0069 0.1012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Toxoplasma gondii aspartyl protease 0.0039 0.0004 0.0074
Brugia malayi hypothetical protein 0.0036 0.0001 0.0001
Brugia malayi pregnancy-associated plasma protein-A 0.0036 0.0001 0.0001
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0073 0.177
Onchocerca volvulus 0.0077 0.004 0.0595
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0712 0.0642 0.0642
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0081 0.0044 0.5
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0013 0.0013
Echinococcus multilocularis discoidin domain containing receptor 2 0.0052 0.0017 0.0021
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0023 0.0023
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0465 0.0408 0.55
Onchocerca volvulus 0.0036 0.0001 0.0019
Echinococcus granulosus integrin alpha 3 0.0688 0.062 0.062
Echinococcus granulosus fibrillin 1 0.0112 0.0074 0.0074
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0112 0.0073 0.0073
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0039 0.0004 0.0004
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.0028 0.0423
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0635 0.0569 0.0569
Echinococcus multilocularis nmda type glutamate receptor 0.0113 0.0074 0.0093
Echinococcus multilocularis 0.8481 0.8004 1
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0294 0.0246 0.288
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Plasmodium falciparum plasmepsin VII 0.0039 0.0004 0.0074
Brugia malayi neuroendocrine convertase 1 precursor 0.6687 0.6304 0.6304
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0465 0.0408 1
Toxoplasma gondii bicoid-interacting protein BIN3 0.0106 0.0068 0.163
Brugia malayi Stress-activated protein kinase jnk-1 0.0239 0.0194 0.0194
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0112 0.0073 0.012
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0239 0.0194 0.0242
Loa Loa (eye worm) hypothetical protein 0.011 0.0071 0.0071
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0013 0.0016
Echinococcus granulosus discoidin domain receptor 0.0052 0.0017 0.0017
Brugia malayi EGF-like domain containing protein 0.011 0.0071 0.0071
Echinococcus granulosus fibrillin 2 0.011 0.0071 0.0071
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0106 0.0068 0.0111
Plasmodium falciparum LCCL domain-containing protein 0.0052 0.0017 0.0375
Echinococcus granulosus nmda type glutamate receptor 0.0113 0.0074 0.0074
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0085 0.0048 0.0801
Giardia lamblia Tenascin precursor 0.011 0.0071 0.0134
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0465 0.0408 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0013 0.0016
Brugia malayi aspartic protease BmAsp-2, identical 0.0039 0.0004 0.0004
Giardia lamblia Tenascin-37 0.011 0.0071 0.0134
Schistosoma mansoni integrin beta subunit 0.2423 0.2263 0.2263
Loa Loa (eye worm) hypothetical protein 0.014 0.01 0.01
Plasmodium vivax subtilisin-like protease 1 0.0465 0.0408 1
Onchocerca volvulus 0.0098 0.006 0.0884
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0054 0.0018 0.041
Echinococcus granulosus c4b binding protein beta chain 0.0036 0.0001 0.0001
Brugia malayi transcriptional regulator, Sir2 family protein 0.0759 0.0687 0.0687
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.2106 0.1963 0.3218
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.0013 0.0013
Toxoplasma gondii aspartyl protease ASP3 0.0039 0.0004 0.0074
Loa Loa (eye worm) acyl carrier protein 0.0038 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.0052 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.011 0.0071 0.0071
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0112 0.0073 0.0092
Onchocerca volvulus 0.0036 0.0001 0.0019
Plasmodium vivax hypothetical protein, conserved 0.014 0.01 0.2433
Mycobacterium leprae Probable polyketide synthase Pks1 0.0085 0.0048 0.0801
Loa Loa (eye worm) hypothetical protein 0.0136 0.0096 0.0096
Toxoplasma gondii SWIRM domain-containing protein 0.0058 0.0023 0.0523
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0694 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0001
Plasmodium vivax LCCL domain-containing protein 0.0052 0.0017 0.0375
Toxoplasma gondii histone lysine-specific demethylase 0.014 0.01 0.2433
Onchocerca volvulus 0.0465 0.0408 0.6023
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0039 0.0004 0.0004
Brugia malayi Reprolysin 0.0053 0.0017 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0465 0.0408 0.0669
Brugia malayi SWIRM domain containing protein 0.075 0.0678 0.0678
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0107 0.0069 0.0069
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 1.0587 1 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0224 0.0179 0.0179
Echinococcus granulosus discoidin domain containing receptor 2 0.0052 0.0017 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.2106 0.1963 0.3218

Activities

Activity type Activity value Assay description Source Reference
GR (binding) = 0.76 GABA ratio (where GABA ratio = IC50 (compound) / IC50 (compound + 10 uM GABA)). ChEMBL. 7783151
Ki (binding) = 42.2 nM Binding affinity at bovine Benzodiazepine receptor by [3H]-flunitrazepam displacement. ChEMBL. 7783151

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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