Detailed information for compound 1191434

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.289 | Formula: C17H14O6
  • H donors: 3 H acceptors: 4 LogP: 3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1O)c1cc(=O)c2c(o1)cc(cc2O)O
  • InChi: 1S/C17H14O6/c1-2-22-15-5-9(3-4-11(15)19)14-8-13(21)17-12(20)6-10(18)7-16(17)23-14/h3-8,18-20H,2H2,1H3
  • InChiKey: CAIHJQODXVKKJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 33.4 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Dopamine transporter   619 aa 557 aa 23.9 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Dopamine transporter   619 aa 522 aa 36.0 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Dopamine transporter   619 aa 599 aa 44.2 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 558 aa 41.8 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Dopamine transporter   619 aa 551 aa 39.9 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Echinococcus multilocularis sodium and chloride dependent glycine Dopamine transporter   619 aa 599 aa 41.9 %
Echinococcus granulosus sodium and chloride dependent glycine Dopamine transporter   619 aa 594 aa 41.4 %
Onchocerca volvulus Transmembrane protein 120 homolog Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Dopamine transporter   619 aa 509 aa 40.1 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Plasmodium vivax hypothetical protein, conserved Dopamine transporter   619 aa 657 aa 20.1 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 588 aa 40.3 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 636 aa 31.8 %
Onchocerca volvulus Dopamine transporter   619 aa 612 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-lactamase 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0183 0.0444
Echinococcus multilocularis dual specificity 0.0102 0.0509 0.0509
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0219 0.0531
Trypanosoma brucei PAB1-binding protein , putative 0.004 0.0153 0.0307
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0102 0.0496
Schistosoma mansoni alpha-glucosidase 0.0118 0.0599 0.1455
Loa Loa (eye worm) hypothetical protein 0.0268 0.1452 0.7085
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0549 0.2679
Schistosoma mansoni peroxidasin 0.0039 0.0146 0.0354
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0073 0.0178
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0053 0.0128
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0179 0.0435
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Plasmodium falciparum transporter, putative 0.0019 0.003 0.0925
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0053 0.0533
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0321 0.131
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0102 0.0203
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0016 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0032 0.0107 0.0391
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0102 0.0247
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.1778
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.0183 0.0183
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Echinococcus granulosus dnaJ subfamily B 0.0734 0.412 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0053 0.0167
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0003 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.0153 0.0307
Loa Loa (eye worm) cysteine protease 0.0017 0.0018 0.009
Echinococcus granulosus cpg binding protein 0.0103 0.0514 0.1248
Trichomonas vaginalis set domain proteins, putative 0.0423 0.2342 1
Loa Loa (eye worm) MBCTL1 0.0052 0.0219 0.1068
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Leishmania major pyruvate kinase 0.007 0.0321 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Echinococcus granulosus flap endonuclease 1 0.0022 0.0049 0.0119
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0016 0.0038
Plasmodium vivax pyruvate kinase, putative 0.007 0.0321 1
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0053 0.0533
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.003 0.0072
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0179 0.0435
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0695 0.3392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0053 0.0176
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0003 0.0006
Onchocerca volvulus 0.0023 0.0053 0.0149
Giardia lamblia DINP protein human, muc B family 0.005 0.0211 0.5495
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.0007 0.0035
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0321 0.0641
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0321 0.1301
Schistosoma mansoni microtubule-associated protein tau 0.0582 0.3249 0.7886
Toxoplasma gondii aldehyde dehydrogenase 0.0097 0.0477 0.4807
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0018 0.0574
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0364 0.1204
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0102 0.0203
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0146 0.0549
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0016 0.0077
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0018 0.0018
Brugia malayi hypothetical protein 0.0039 0.0146 0.0712
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0131 0.0262
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.003 0.0072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0239 0.0239
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0321 0.1301
Mycobacterium ulcerans hypothetical protein 0.0077 0.0364 0.1204
Plasmodium vivax vivapain-2 0.0017 0.0018 0.0574
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0018 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.1118 0.2714
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0053 0.0167
Plasmodium vivax vivapain-2 0.0017 0.0018 0.0574
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.1118 0.5455
Echinococcus granulosus Protein patched homolog 1 0.009 0.0436 0.1059
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.003 0.003
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Schistosoma mansoni pyruvate kinase 0.0036 0.0127 0.0309
Echinococcus multilocularis beta LACTamase domain containing family member 0.0028 0.0081 0.0081
Brugia malayi beta-lactamase family protein 0.0028 0.0081 0.0394
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0097 0.0477 0.0477
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0102 0.0369
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Brugia malayi CXXC zinc finger family protein 0.0098 0.0482 0.2353
Brugia malayi serine/threonine-protein kinase plk-2 0.008 0.0382 0.1862
Brugia malayi polk-prov protein 0.0036 0.0131 0.0639
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0016 0.0016
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.0183 0.0444
Echinococcus granulosus serine:threonine protein kinase PLK1 0.008 0.0382 0.0926
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.002 0.0049
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0364 0.3162
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0003 0.0006
Schistosoma mansoni pyruvate kinase 0.007 0.0321 0.0778
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0489 0.1626
Toxoplasma gondii hypothetical protein 0.0143 0.0742 0.7471
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.0049
Mycobacterium tuberculosis Conserved protein 0.0028 0.0081 0.0268
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0016 0.0016
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0179 0.0874
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0016 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0032 0.0107 0.0346
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0032 0.0107 0.3329
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0219 0.0219
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0081 0.0161
Loa Loa (eye worm) hypothetical protein 0.0113 0.0566 0.2763
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.003 0.0145
Mycobacterium tuberculosis Probable esterase LipL 0.0028 0.0081 0.0268
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Trypanosoma brucei polo-like protein kinase 0.008 0.0382 0.0764
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0748
Loa Loa (eye worm) ctsf protein 0.0017 0.0018 0.009
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Echinococcus multilocularis cysteine protease 0.0017 0.0018 0.0018
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0048 0.02 0.0978
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0235 0.1148
Loa Loa (eye worm) hypothetical protein 0.0055 0.0239 0.1165
Loa Loa (eye worm) hypothetical protein 0.011 0.0551 0.2691
Mycobacterium tuberculosis Probable lipase LipD 0.0028 0.0081 0.0268
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0253 0.789
Trypanosoma brucei unspecified product 0.0062 0.0276 0.0551
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Onchocerca volvulus 0.0055 0.0235 0.0933
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Echinococcus granulosus muscleblind protein 0.0113 0.0566 0.1375
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0003 0.0007
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.0183 0.0893
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0034 0.0083
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0179 0.0596
Onchocerca volvulus 0.0423 0.2342 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.1118 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0018 0.0023
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0053 0.0167
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0081 0.0196
Echinococcus granulosus pyruvate kinase 0.0036 0.0127 0.0309
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.1778
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.042 0.2325 0.4652
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0053 0.0176
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Leishmania major pyruvate kinase 0.007 0.0321 0.0641
Schistosoma mansoni alpha-glucosidase 0.0118 0.0599 0.1455
Leishmania major DNA polymerase eta, putative 0.0066 0.0302 0.0604
Leishmania major cathepsin L-like protease 0.0063 0.0285 0.0571
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0018 0.0045
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0127 0.397
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0888 0.4998 1
Chlamydia trachomatis pyruvate kinase 0.007 0.0321 1
Echinococcus granulosus Regulator of G protein signaling 20 0.0016 0.0016 0.0038
Echinococcus granulosus expressed conserved protein 0.0196 0.1046 0.2538
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.002 0.0049
Leishmania major DNA polymerase kappa, putative 0.0014 0.0003 0.0006
Toxoplasma gondii hypothetical protein 0.0019 0.003 0.0299
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0098 0.0742
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.0983 0.2386
Brugia malayi PXA domain containing protein 0.0016 0.0016 0.0077
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0053 0.0159
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Brugia malayi hypothetical protein 0.0026 0.0072 0.0351
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0016 0.0038
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0085 0.0415
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0098 0.0352
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0016 0.0038
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0115 0.0581 0.1411
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Trichomonas vaginalis DNA polymerase eta, putative 0.0067 0.0307 0.1253
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Toxoplasma gondii exonuclease III APE 0.0032 0.0107 0.1074
Mycobacterium ulcerans aldehyde dehydrogenase 0.0097 0.0477 0.158
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.003 0.0072
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.054 0.3006 1
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0364 0.1778
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0016 0.0038
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0055 0.0239 0.2405
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0073 0.0178
Schistosoma mansoni patched 1 0.009 0.0436 0.1059
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0016 0.0016 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0581 0.1411
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0032 0.0107 0.0213
Loa Loa (eye worm) hypothetical protein 0.0109 0.0549 0.2679
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0032 0.0107 0.0259
Onchocerca volvulus 0.0077 0.0364 0.1489
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0102 0.0509 0.1018
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0085 0.0415
Giardia lamblia Kinase, PLK 0.008 0.0382 1
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0415
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.002 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0126 0.0251
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0364 0.1204
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0053 0.1651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus granulosus nibrin 0.0031 0.0102 0.0247
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Brugia malayi hypothetical protein 0.0016 0.0016 0.0077
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0107 0.0261
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0072
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0152 0.0585
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0053 0.0176
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0302 0.0604
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0081 0.0279
Brugia malayi mbt repeat family protein 0.0045 0.0183 0.0893
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0131 0.0262
Toxoplasma gondii hypothetical protein 0.0019 0.003 0.0299
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0098 0.0352
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.003 0.003
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0028 0.0081 0.0268
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0509 0.1018
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0321 0.131
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0085 0.0415
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0364 0.1204
Onchocerca volvulus 0.0109 0.0549 0.2284
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Plasmodium vivax flap endonuclease 1, putative 0.0022 0.0049 0.1527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Echinococcus multilocularis pyruvate kinase 0.0036 0.0127 0.0127
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0018 0.0037
Echinococcus multilocularis microtubule associated protein 2 0.0582 0.3249 0.3249
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0219 0.0531
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.009 0.0436 0.2128
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0102 0.0509 0.2483
Brugia malayi hypothetical protein 0.0041 0.0156 0.0761
Leishmania major alpha glucosidase II subunit, putative 0.003 0.0098 0.0195
Echinococcus multilocularis muscleblind protein 0.0113 0.0566 0.0566
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.001 0.0049
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0022 0.0049 0.0098
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0208 0.0416
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0053 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0028 0.0081 0.0259
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Plasmodium vivax hypothetical protein, conserved 0.0019 0.003 0.0925
Schistosoma mansoni intermediate filament proteins 0.0028 0.0085 0.0206
Plasmodium falciparum pyruvate kinase 0.007 0.0321 1
Echinococcus multilocularis neutral alpha glucosidase AB 0.003 0.0098 0.0098
Schistosoma mansoni flap endonuclease-1 0.002 0.0037 0.009
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0032 0.0107 0.0521
Loa Loa (eye worm) pyruvate kinase 0.007 0.0321 0.1564
Trypanosoma brucei pyruvate kinase 1 0.007 0.0321 0.0641
Echinococcus multilocularis regulator of G protein signaling 0.0016 0.0016 0.0016
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.1631 0.3958
Leishmania major DNA polymerase kappa, putative 0.005 0.0211 0.0422
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0074 0.036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Trypanosoma brucei unspecified product 0.0031 0.01 0.02
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.036
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0239 0.058
Mycobacterium tuberculosis Conserved hypothetical protein 0.0468 0.2597 0.8638
Echinococcus multilocularis musashi 0.0028 0.0085 0.0085
Echinococcus multilocularis pyruvate kinase 0.0055 0.0237 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0436 0.1807
Brugia malayi pyruvate kinase 0.0015 0.0007 0.0035
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.042 0.2325 0.4652
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0003 0.0006
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0125 0.0637 0.1274
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0219 0.0531
Schistosoma mansoni hypothetical protein 0.0734 0.412 1
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0102 0.0369
Onchocerca volvulus 0.0019 0.003 0.0048
Loa Loa (eye worm) hypothetical protein 0.0102 0.0504 0.2462
Schistosoma mansoni hypothetical protein 0.0055 0.0235 0.0571
Schistosoma mansoni lamin 0.0028 0.0085 0.0206
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Brugia malayi hypothetical protein 0.0031 0.0102 0.0496
Onchocerca volvulus 0.0028 0.0081 0.0268
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.1118 0.1118
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.0183 0.0708
Brugia malayi Pre-SET motif family protein 0.0055 0.0239 0.1165
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.002 0.0099
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.1452 0.1452
Schistosoma mansoni topbp1 0.0031 0.0102 0.0247
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0285 0.0571
Echinococcus multilocularis serotonin transporter 0.0109 0.0549 0.0549
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.0153 0.4785
Entamoeba histolytica cysteine protease, putative 0.0017 0.0018 0.0023
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0028 0.0081 0.0268
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0003 0.0006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Echinococcus multilocularis lysosomal alpha glucosidase 0.0137 0.0709 0.0709
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0055 0.0239 0.058
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0254 0.0508
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Echinococcus multilocularis lysosomal alpha glucosidase 0.0137 0.0709 0.0709
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0018 0.0045
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0072
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0053 0.0258
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0321 0.1301
Mycobacterium ulcerans lipase LipD 0.0028 0.0081 0.0259
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Echinococcus multilocularis lamin 0.0028 0.0085 0.0085
Onchocerca volvulus 0.0028 0.0081 0.0268
Echinococcus multilocularis dna polymerase eta 0.0066 0.0302 0.0302
Onchocerca volvulus 0.0028 0.0085 0.0287
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Echinococcus multilocularis cpg binding protein 0.0103 0.0514 0.0514
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0125 0.0637 0.1274
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0018 0.009
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0364 0.1204
Echinococcus granulosus lamin dm0 0.0028 0.0085 0.0206
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0436 0.2128
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.003 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Echinococcus granulosus microtubule associated protein 2 0.0582 0.3249 0.7886
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0053 0.0167
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.0321 0.1066
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.005 0.0211 0.0702
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.003 0.0072
Mycobacterium ulcerans hypothetical protein 0.0099 0.0489 0.1618
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0102 0.0509 0.1018
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0028 0.0081 0.0268
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.0153 0.0307
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0053 0.0167
Brugia malayi hypothetical protein 0.004 0.0153 0.0748
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0102 0.0778
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0065
Onchocerca volvulus 0.0019 0.003 0.0048
Entamoeba histolytica hypothetical protein 0.0031 0.0102 0.0778
Onchocerca volvulus 0.0028 0.0081 0.0268
Loa Loa (eye worm) hypothetical protein 0.0113 0.0566 0.2763
Plasmodium vivax amine transporter, putative 0.0019 0.003 0.0925
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0098 0.0742
Onchocerca volvulus 0.0105 0.0524 0.2175
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.054 0.3006 1
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.008 0.0382 0.0382
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus multilocularis expressed conserved protein 0.0196 0.1046 0.1046
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.0307 0.0615
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0032 0.0107 0.0213
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0253 0.0833
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0053 0.0167
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0143 0.07
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0073 0.0073
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0003 0.0088
Echinococcus granulosus pyruvate kinase 0.007 0.0321 0.0778
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0049 0.0142
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0549 0.1333
Loa Loa (eye worm) hypothetical protein 0.0036 0.0131 0.0639
Leishmania major mitochondrial DNA polymerase beta 0.0888 0.4998 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0018 0.0027 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Trichomonas vaginalis ap endonuclease, putative 0.0032 0.0107 0.0391
Loa Loa (eye worm) hypothetical protein 0.0209 0.1118 0.5455
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0016 0.0016
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.002 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Mycobacterium ulcerans hypothetical protein 0.0099 0.0489 0.1618
Echinococcus granulosus neutral alpha glucosidase AB 0.003 0.0098 0.0237
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Mycobacterium ulcerans esterase/lipase LipP 0.0028 0.0081 0.0259
Echinococcus granulosus lamin 0.0028 0.0085 0.0206
Leishmania major cathepsin L-like protease 0.0063 0.0285 0.0571
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Entamoeba histolytica hypothetical protein 0.0102 0.0509 0.4474
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0364 0.3162
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.0321 0.1564
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0018 0.0037
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0098 0.0352
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0239 0.058
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Brugia malayi hypothetical protein 0.0016 0.0016 0.0077
Entamoeba histolytica protein kinase, putative 0.0102 0.0509 0.4474
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0016 0.0038
Echinococcus granulosus dna polymerase kappa 0.0067 0.0307 0.0746
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0016 0.0038
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0032 0.0107 0.2742
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0302 0.0604
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Mycobacterium ulcerans aldehyde dehydrogenase 0.0097 0.0477 0.158
Mycobacterium ulcerans hypothetical protein 0.0028 0.0081 0.0259
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.0382 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0098 0.0195
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0102 0.0247
Echinococcus granulosus pyruvate kinase 0.0036 0.0127 0.0309
Onchocerca volvulus 0.0039 0.0146 0.0549
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0081 0.0279
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.009
Entamoeba histolytica protein kinase, putative 0.0102 0.0509 0.4474
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0143 0.07
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Echinococcus granulosus peroxidasin 0.0039 0.0146 0.0354
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0436 0.1059
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0098 0.0477
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0053 0.0176
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0219 0.1068
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0003 0.0088
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0146 0.0549
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0364 0.1204
Brugia malayi exodeoxyribonuclease III family protein 0.0032 0.0107 0.0521
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0115 0.0581 0.0581
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.0307 0.1014
Echinococcus multilocularis dna polymerase kappa 0.0067 0.0307 0.0307
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Plasmodium falciparum amino acid transporter, putative 0.0019 0.003 0.0925
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0176 0.0928 0.3088
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0066 0.0302 0.1473
Echinococcus multilocularis pyruvate kinase 0.007 0.0321 0.0321
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.005 0.0211 0.0422
Leishmania major hypothetical protein, conserved 0.004 0.0153 0.0307
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0179 0.1482
Toxoplasma gondii cathepsin CPL 0.0017 0.0018 0.0185
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0081 0.0094
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0001 0.0003
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0018 0.0045
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Echinococcus multilocularis flap endonuclease 1 0.0022 0.0049 0.0049
Onchocerca volvulus Peroxidase homolog 0.0039 0.0146 0.0549
Brugia malayi PXA domain containing protein 0.0016 0.0016 0.0077
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.002 0.0049
Toxoplasma gondii ABC1 family protein 0.0028 0.0081 0.0813
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0285 0.0571
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0072
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.02 0.0978
Entamoeba histolytica serine/threonine protein kinase, putative 0.008 0.0382 0.3319
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Brugia malayi Blistered cuticle protein 3 0.0039 0.0146 0.0712
Brugia malayi hypothetical protein 0.0031 0.0102 0.0496
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0018 0.009
Echinococcus multilocularis expressed protein 0.0315 0.1722 0.1722
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0035 0.0349
Toxoplasma gondii histone lysine methyltransferase SET1 0.0187 0.0993 1
Onchocerca volvulus 0.0098 0.0482 0.1996
Loa Loa (eye worm) flap endonuclease-1 0.0022 0.0049 0.0239
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0032 0.0107 0.3329
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0018 0.0018
Mycobacterium tuberculosis Conserved protein 0.0028 0.0081 0.0268
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.003 0.003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0018 0.0018
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0053 0.0053
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Echinococcus granulosus cathepsin l1 0.0017 0.0018 0.0045
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0035 0.0116
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.042 0.2325 0.4652
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0098 0.0195
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0099 0.0489 0.1618
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0212 0.1137 0.2759
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0299
Echinococcus multilocularis geminin 0.0594 0.3317 0.3317
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0081 0.0279
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0053 0.0533
Loa Loa (eye worm) hypothetical protein 0.0109 0.0549 0.2679
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0102 0.0496
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0102 0.317
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.008 0.0382 0.0764
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0081 0.0161
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0364 0.0729
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0072
Loa Loa (eye worm) hypothetical protein 0.007 0.0321 0.1564
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0107 0.0107
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0115 0.0581 0.1411
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0102 0.0369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Mycobacterium tuberculosis Probable lipase LipE 0.0028 0.0081 0.0268
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0152 0.0585
Schistosoma mansoni kinase 0.0041 0.0158 0.0383
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0044 0.0213
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.1778
Loa Loa (eye worm) hypothetical protein 0.0109 0.0549 0.2679
Schistosoma mansoni aldehyde dehydrogenase 0.0097 0.0477 0.1159
Schistosoma mansoni topbp1 0.0031 0.0102 0.0247
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.054 0.3006 1
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.054 0.3006 1
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.002 0.0099
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0156 0.0379
Echinococcus multilocularis protein patched 0.009 0.0436 0.0436
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0364 0.1204
Schistosoma mansoni DNA polymerase eta 0.0066 0.0302 0.0733
Loa Loa (eye worm) oxidoreductase 0.0023 0.0053 0.0258
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0016 0.0077
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Brugia malayi Glycosyl hydrolases family 31 protein 0.0137 0.0709 0.3457
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0276 0.0551
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0102 0.0203
Brugia malayi mbt repeat family protein 0.0045 0.0183 0.0893
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0032 0.0107 0.0107
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0364 0.1212
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0695 0.3392
Mycobacterium ulcerans beta-lactamase 0.0028 0.0081 0.0259
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Echinococcus granulosus serotonin transporter 0.0109 0.0549 0.1333
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0102 0.0369
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0105 0.0524 0.2555
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.0983 0.0983
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.02 0.1675
Onchocerca volvulus Peroxidase homolog 0.0039 0.0146 0.0549
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0239 0.058
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0211 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0081 0.0161
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0032 0.0107 0.0018
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0888 0.4998 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0032 0.0107 0.0213
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Onchocerca volvulus 0.0023 0.0053 0.0149
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0097 0.0477 0.1588
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0156 0.0156
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0102 0.0369
Brugia malayi regulator of G-protein signaling rgs-7 0.0016 0.0016 0.0077
Schistosoma mansoni DNA ligase IV 0.0031 0.0102 0.0247
Leishmania major DNA damage repair protein, putative 0.0014 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0156 0.0379
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0321 0.0641
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0099 0.0489 0.4921
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0183 0.0444
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0581 0.1411
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0102 0.1023
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0549 0.2679
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0239 0.058
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0132 0.0263
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0053 0.0167
Brugia malayi DKFZp564C0469 protein 0.0031 0.0102 0.0496
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0018 0.0023
Loa Loa (eye worm) hypothetical protein 0.0102 0.0504 0.2462
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0132 0.0263
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Mycobacterium tuberculosis Conserved protein 0.0028 0.0081 0.0268
Giardia lamblia Pyruvate kinase 0.0036 0.0127 0.3285
Schistosoma mansoni hypothetical protein 0.0026 0.0074 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.0307 0.0615
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0364 0.1055
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0053 0.1651
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0143 0.07
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0003 0.0028
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0364 0.1778
Schistosoma mansoni survival motor neuron protein 0.0055 0.0235 0.0571
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0364 0.3162
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0489 0.1626
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0549 0.1333
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.04
Brugia malayi MH2 domain containing protein 0.0135 0.0695 0.3392
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.0183 0.0444
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.0307 0.1014
Onchocerca volvulus 0.0028 0.0085 0.0287
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0022 0.0049 0.0493
Echinococcus multilocularis protein dispatched 1 0.0102 0.0509 0.0509
Schistosoma mansoni ap endonuclease 0.0032 0.0107 0.0259
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0302 0.1473
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0132 0.0263
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0051 0.0215 0.0523
Mycobacterium leprae Probable lipase LipE 0.0028 0.0081 0.0094
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0115 0.0581 0.2836
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.003 0.003
Schistosoma mansoni alpha glucosidase 0.003 0.0098 0.0237
Brugia malayi beta-lactamase 0.0028 0.0081 0.0394
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0003 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0382 0.0926
Brugia malayi Protein kinase domain containing protein 0.0102 0.0509 0.2483
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0581 0.1411
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.0321 0.0641
Echinococcus multilocularis peroxidasin 0.0039 0.0146 0.0146
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0097 0.0477 0.1159
Loa Loa (eye worm) hypothetical protein 0.0045 0.0183 0.0893
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0209 0.112 0.2718
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0102 0.1023
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0081 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0509 0.1235
Onchocerca volvulus 0.0055 0.0239 0.0949
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0018 0.0574
Schistosoma mansoni cpg binding protein 0.0103 0.0514 0.1248
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.003 0.0072
Brugia malayi Muscleblind-like protein 0.0113 0.0566 0.2763
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0072
Loa Loa (eye worm) RGS-3 protein 0.0016 0.0016 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0081 0.0196
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0053 0.0176
Echinococcus multilocularis cysteine protease 0.0017 0.0018 0.0018
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0299
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0509 0.4474
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0253 0.789
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0107 0.0524
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0125 0.0637 0.1274
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0549 0.2679
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0372 0.205 1
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0146 0.0549
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0299
Onchocerca volvulus 0.0023 0.0053 0.0149
Loa Loa (eye worm) pyruvate kinase 0.0015 0.0007 0.0035
Mycobacterium ulcerans pyruvate kinase 0.007 0.0321 0.1058
Leishmania major cathepsin L-like protease 0.0063 0.0285 0.0571
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0285 0.0571
Echinococcus multilocularis lamin dm0 0.0028 0.0085 0.0085
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0003 0.0006
Schistosoma mansoni cpg binding protein 0.0098 0.0482 0.117
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0016 0.0077
Echinococcus granulosus pyruvate kinase 0.007 0.0321 0.0778
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0258
Onchocerca volvulus 0.0079 0.0378 0.1546
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0258
Trypanosoma brucei glucosidase, putative 0.003 0.0098 0.0195
Brugia malayi Flap endonuclease-1 0.0022 0.0049 0.0239
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0032 0.0107 0.0355
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0073 0.0178
Trichomonas vaginalis helicase, putative 0.0022 0.005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.0183 0.0444
Plasmodium vivax SET domain protein, putative 0.0055 0.0239 0.7451
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0053 0.0176
Echinococcus multilocularis muscleblind protein 1 0.0113 0.0566 0.0566
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.003 0.0072
Trichomonas vaginalis sucrase-isomaltase, putative 0.003 0.0098 0.0352
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0888 0.4998 1
Leishmania major DNA polymerase eta, putative 0.0035 0.0126 0.0251
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0067 0.0307 0.1253
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0016 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0003 0.0006
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0253 0.0841
Mycobacterium ulcerans aldehyde dehydrogenase 0.0097 0.0477 0.158
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0364 0.1212
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0022 0.0049 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus granulosus beta LACTamase domain containing family member 0.0028 0.0081 0.0196
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0115 0.0581 0.0581
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0364 0.1778
Echinococcus granulosus intermediate filament protein 0.0028 0.0085 0.0206
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.0321 0.1564
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0364 0.1204
Brugia malayi A-kinase anchor protein 10, precursor 0.0016 0.0016 0.0077
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0016 0.0016
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.0183 0.0183
Toxoplasma gondii LsmAD domain-containing protein 0.004 0.0153 0.1545
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.0153 0.4785
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0028 0.0081 0.0394
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Echinococcus multilocularis pyruvate kinase 0.0036 0.0127 0.0127
Echinococcus multilocularis pyruvate kinase 0.007 0.0321 0.0321
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Brugia malayi intermediate filament protein 0.0028 0.0085 0.0415
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.003 0.0072
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.002 0.0099
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0018 0.0045
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0032 0.0107 0.0213
Schistosoma mansoni cpg binding protein 0.0103 0.0514 0.1248
Entamoeba histolytica Flap nuclease, putative 0.0022 0.0049 0.03
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0081 0.0279
Treponema pallidum exodeoxyribonuclease (exoA) 0.0032 0.0107 0.0114
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0102 0.0165
Plasmodium vivax ataxin-2 like protein, putative 0.004 0.0153 0.4785
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium ulcerans hypothetical protein 0.0468 0.2597 0.8636
Onchocerca volvulus 0.0023 0.0053 0.0149
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0022 0.0049 0.0098
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0146 0.0712
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0285 0.0571
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0102 0.0203
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0102 0.317
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0179 0.0874
Echinococcus granulosus geminin 0.0594 0.3317 0.805
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.1452 0.3524
Onchocerca volvulus 0.0045 0.0183 0.0708
Mycobacterium tuberculosis Probable hydrolase 0.0028 0.0081 0.0268
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0793 0.1587
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Leishmania major hypothetical protein, conserved 0.0028 0.0081 0.0161
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0102 0.0329
Echinococcus multilocularis dnaJ subfamily B 0.0734 0.412 0.412
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.003 0.0098 0.0477
Schistosoma mansoni hypothetical protein 0.0041 0.0156 0.0379
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0364 0.0729
Schistosoma mansoni ap endonuclease 0.0032 0.0107 0.0259
Echinococcus granulosus tumor protein p63 0.0718 0.4024 0.9766
Giardia lamblia Pyruvate kinase 0.007 0.0321 0.8387
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0179 0.0435
Echinococcus granulosus expressed protein 0.0315 0.1722 0.418
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0364 0.0729
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0115 0.0581 0.2836
Loa Loa (eye worm) pyruvate kinase 0.007 0.0321 0.1564
Echinococcus multilocularis tumor protein p63 0.0718 0.4024 0.4024
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0097 0.0477 0.0955
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0018 0.0574
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.005 0.0147
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0436 0.0436
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0053 0.0128
Giardia lamblia Flap structure-specific endonuclease 0.0022 0.0049 0.1217
Schistosoma mansoni pyruvate kinase 0.007 0.0321 0.0778
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.1631 0.1631
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Echinococcus granulosus dna polymerase eta 0.0066 0.0302 0.0733
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.003 0.0072
Echinococcus granulosus pyruvate kinase 0.0036 0.0127 0.0309
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0007
Trypanosoma brucei unspecified product 0.0031 0.01 0.02
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0073 0.0073
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.005 0.0147
Schistosoma mansoni aldehyde dehydrogenase 0.0097 0.0477 0.1159
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0081 0.2518
Schistosoma mansoni hypothetical protein 0.0283 0.1538 0.3733
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0146 0.0549
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0137 0.0709 0.3457
Onchocerca volvulus Serine\/threonine kinase homolog 0.008 0.0382 0.1564
Schistosoma mansoni peroxidasin 0.0039 0.0146 0.0354
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.0637 0.1274
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0053 0.0159
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0053 0.0176
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.008 0.0382 0.1862
Brugia malayi beta-lactamase family protein 0.0028 0.0081 0.0394
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.003 0.0098 0.0983
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0105 0.0514
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Onchocerca volvulus 0.0019 0.003 0.0048
Echinococcus multilocularis pyruvate kinase 0.0036 0.0127 0.0127
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0053 0.0167
Loa Loa (eye worm) pyruvate kinase 0.007 0.0321 0.1564
Schistosoma mansoni hypothetical protein 0.0594 0.3317 0.805
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0016 0.0016
Echinococcus granulosus dual specificity 0.0102 0.0509 0.1235
Echinococcus multilocularis nibrin 0.0031 0.0102 0.0102
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0053 0.0336
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0015 0.0036
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0364 0.1055
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Brugia malayi CHE-14 protein 0.009 0.0436 0.2128
Brugia malayi Peroxidasin 0.0039 0.0146 0.0712
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0524 0.1271
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0126 0.1265
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Loa Loa (eye worm) PXA domain-containing protein 0.0016 0.0016 0.0077
Brugia malayi hypothetical protein 0.0019 0.003 0.0145
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Plasmodium falciparum flap endonuclease 1 0.0022 0.0049 0.1527
Loa Loa (eye worm) hypothetical protein 0.0052 0.0219 0.1068
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0053 0.0167
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0253 0.7675
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0072
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0509 0.1018
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0072
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0127 0.397
Loa Loa (eye worm) CXXC zinc finger family protein 0.0098 0.0482 0.2353
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0055 0.0239 0.0239
Onchocerca volvulus 0.0031 0.0102 0.0358
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0549 0.2679
Onchocerca volvulus 0.0039 0.0146 0.0549
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) fibroinase 0.0017 0.0018 0.009
Chlamydia trachomatis DNA ligase 0.0031 0.0102 0.2473
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0032 0.0107 0.0825
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0179 0.0179
Brugia malayi hypothetical protein 0.0268 0.1452 0.7085
Echinococcus multilocularis Regulator of G protein signaling 20 0.0016 0.0016 0.0016
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.0549 1
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0016 0.0077
Schistosoma mansoni lamin 0.0028 0.0085 0.0206
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.07
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0016 0.0016 0.0038
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0127 0.1282
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.0321 0.0906
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Brugia malayi Pre-SET motif family protein 0.0372 0.205 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0102 0.2608
Echinococcus granulosus lysosomal alpha glucosidase 0.0137 0.0709 0.172
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0102 0.0203
Treponema pallidum licC protein (licC) 0.0099 0.0489 0.8651
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.0382 0.0764
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.0321 0.3228
Brugia malayi topoisomerase 0.0031 0.0102 0.0496
Trichomonas vaginalis esterase, putative 0.0028 0.0081 0.0279
Onchocerca volvulus 0.0039 0.0146 0.0549
Schistosoma mansoni hypothetical protein 0.0594 0.3317 0.805

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 12.856 uM Agonist activity at rat DAT expressed in CHO cells ChEMBL. 20971650

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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