Detailed information for compound 1191434

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 314.289 | Formula: C17H14O6
  • H donors: 3 H acceptors: 4 LogP: 3 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1cc(ccc1O)c1cc(=O)c2c(o1)cc(cc2O)O
  • InChi: 1S/C17H14O6/c1-2-22-15-5-9(3-4-11(15)19)14-8-13(21)17-12(20)6-10(18)7-16(17)23-14/h3-8,18-20H,2H2,1H3
  • InChiKey: CAIHJQODXVKKJZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Dopamine transporter Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 558 aa 41.8 %
Drosophila melanogaster CG1698 gene product from transcript CG1698-RA Dopamine transporter   619 aa 522 aa 36.0 %
Schistosoma japonicum ko:K05042 solute carrier family 6 (neurotransmitter transporter, glycine),, putative Dopamine transporter   619 aa 509 aa 40.1 %
Neospora caninum sodium-dependent transporter, putative Dopamine transporter   619 aa 498 aa 32.3 %
Echinococcus granulosus sodium and chloride dependent glycine Dopamine transporter   619 aa 594 aa 41.4 %
Schistosoma mansoni sodium/chloride dependent transporter Dopamine transporter   619 aa 588 aa 40.3 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 32.9 %
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter Dopamine transporter   619 aa 604 aa 37.9 %
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 636 aa 31.8 %
Plasmodium vivax hypothetical protein, conserved Dopamine transporter   619 aa 657 aa 20.1 %
Onchocerca volvulus Dopamine transporter   619 aa 612 aa 23.5 %
Onchocerca volvulus Transmembrane protein 120 homolog Dopamine transporter   619 aa 578 aa 32.9 %
Echinococcus multilocularis sodium and chloride dependent glycine Dopamine transporter   619 aa 599 aa 41.9 %
Schistosoma japonicum ko:K05046 solute carrier family 6 (neurotransmitter transporter, GABA), member, putative Dopamine transporter   619 aa 551 aa 39.9 %
Onchocerca volvulus High affinity copper uptake protein 1 homolog Dopamine transporter   619 aa 599 aa 44.2 %
Brugia malayi Sodium:neurotransmitter symporter family protein Dopamine transporter   619 aa 578 aa 33.4 %
Drosophila melanogaster CG13796 gene product from transcript CG13796-RD Dopamine transporter   619 aa 557 aa 23.9 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Echinococcus multilocularis SAM and MBT domain containing protein 0.0045 0.0183 0.0183
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0023 0.0053 0.0176
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0077 0.0364 0.1204
Entamoeba histolytica pyruvate kinase, putative 0.0048 0.02 0.1675
Schistosoma mansoni serine/threonine protein kinase 0.008 0.0382 0.0926
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0077 0.0364 0.1212
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Loa Loa (eye worm) pyruvate kinase 0.007 0.0321 0.1564
Echinococcus multilocularis tumor protein p63 0.0718 0.4024 0.4024
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0072
Trypanosoma brucei chrX additional, unordered contigs 0.0014 0.0003 0.0006
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Brugia malayi intermediate filament protein 0.0028 0.0085 0.0415
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0055 0.0239 0.0239
Loa Loa (eye worm) pyruvate kinase-PB 0.0048 0.02 0.0978
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.036
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.008 0.0382 0.0382
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0097 0.0477 0.0477
Schistosoma mansoni hypothetical protein 0.0734 0.412 1
Brugia malayi Pyruvate kinase, muscle isozyme 0.007 0.0321 0.1564
Brugia malayi Pre-SET motif family protein 0.0055 0.0239 0.1165
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0017 0.002 0.0099
Entamoeba histolytica protein kinase, putative 0.0102 0.0509 0.4474
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0023 0.0053 0.0167
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0183 0.0444
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0016 0.0038
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0023 0.0053 0.0167
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0023 0.0053 0.0336
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Brugia malayi CHE-14 protein 0.009 0.0436 0.2128
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0125 0.0637 0.1274
Brugia malayi Peroxidasin 0.0039 0.0146 0.0712
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0073 0.0178
Onchocerca volvulus Peroxidase homolog 0.0039 0.0146 0.0549
Echinococcus multilocularis muscleblind protein 1 0.0113 0.0566 0.0566
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0051 0.0215 0.0523
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0073 0.0178
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0053 0.0159
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Echinococcus multilocularis dnaJ subfamily B 0.0734 0.412 0.412
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0156 0.0379
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0081 0.0161
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0023 0.0053 0.0258
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.009 0.0436 0.2128
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0372 0.205 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.02 0.0978
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0028 0.0081 0.0268
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0035 0.0126 0.1265
Trichomonas vaginalis antibiotic synthetase, putative 0.0023 0.0053 0.0159
Echinococcus multilocularis dna polymerase kappa 0.0067 0.0307 0.0307
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0021 0.0044 0.0213
Onchocerca volvulus 0.0039 0.0146 0.0549
Onchocerca volvulus Peroxidase homolog 0.0039 0.0146 0.0549
Trichomonas vaginalis ap endonuclease, putative 0.0032 0.0107 0.0391
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.002 0.0035 0.0116
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0185 0.0983 0.0983
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0016 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0125 0.0637 0.1274
Trypanosoma brucei DNA polymerase eta, putative 0.0066 0.0302 0.0604
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0152 0.0585
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0067 0.0307 0.1253
Brugia malayi DKFZp564C0469 protein 0.0031 0.0102 0.0496
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0023 0.0053 0.0167
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0018 0.0045
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0016 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0062 0.0276 0.0551
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0509 0.1018
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0321 0.131
Loa Loa (eye worm) hypothetical protein 0.0036 0.0131 0.0639
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0102 0.0203
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0239 0.058
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.0153 0.4785
Onchocerca volvulus 0.0077 0.0364 0.1489
Entamoeba histolytica protein kinase domain containing protein 0.0102 0.0509 0.4474
Onchocerca volvulus 0.0039 0.0146 0.0549
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0016 0.0038
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.0307 0.0615
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0016 0.0016 0.0038
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Plasmodium vivax vivapain-2 0.0017 0.0018 0.0574
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0032 0.0107 0.0213
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Mycobacterium ulcerans hypothetical protein 0.0468 0.2597 0.8636
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Echinococcus granulosus dna polymerase eta 0.0066 0.0302 0.0733
Entamoeba histolytica acyl-coA synthetase, putative 0.0077 0.0364 0.3162
Plasmodium vivax hypothetical protein, conserved 0.0019 0.003 0.0925
Onchocerca volvulus 0.0045 0.0183 0.0708
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Brugia malayi beta-lactamase family protein 0.0028 0.0081 0.0394
Schistosoma mansoni hypothetical protein 0.0018 0.0027 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0015 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.002 0.0049
Echinococcus granulosus survival motor neuron protein 1 0.0268 0.1452 0.3524
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.003 0.0072
Leishmania major cathepsin L-like protease 0.0063 0.0285 0.0571
Echinococcus multilocularis neutral alpha glucosidase AB 0.003 0.0098 0.0098
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0028 0.0081 0.0268
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.0031 0.0102 0.0165
Schistosoma mansoni serine/threonine protein kinase 0.0102 0.0509 0.1235
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0022 0.0049 0.0098
Trypanosoma cruzi DNA polymerase eta, putative 0.0066 0.0302 0.0604
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0058 0.0254 0.0508
Brugia malayi Blistered cuticle protein 3 0.0039 0.0146 0.0712
Echinococcus multilocularis replication factor c subunit 1 0.0031 0.0102 0.0102
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0023 0.0053 0.0176
Loa Loa (eye worm) hypothetical protein 0.009 0.0436 0.2128
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0016 0.0016
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0016 0.0077
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0045 0.0179 0.0435
Brugia malayi ImpB/MucB/SamB family protein 0.0066 0.0302 0.1473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0097 0.0477 0.158
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0019 0.003 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0888 0.4998 1
Leishmania major pyruvate kinase 0.007 0.0321 0.0641
Mycobacterium tuberculosis Probable lipase LipE 0.0028 0.0081 0.0268
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0014 0.0003 0.0028
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0045 0.0179 0.0435
Leishmania major mitochondrial DNA polymerase beta 0.0888 0.4998 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0082 0.04
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0239 0.058
Trypanosoma brucei unspecified product 0.0031 0.01 0.02
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0023 0.0053 0.0167
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Mycobacterium tuberculosis Probable esterase LipL 0.0028 0.0081 0.0268
Plasmodium falciparum flap endonuclease 1 0.0022 0.0049 0.1527
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0016 0.0038
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0016 0.0016 0.0016
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.008 0.0382 0.0764
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0023 0.0053 0.0176
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0131 0.0262
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0017 0.002 0.0099
Brugia malayi Pre-SET motif family protein 0.0372 0.205 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0045 0.0179 0.0435
Schistosoma mansoni DNA ligase IV 0.0031 0.0102 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0321 0.1301
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0081 0.0279
Echinococcus multilocularis sterol regulatory element binding protein 0.009 0.0436 0.0436
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Echinococcus multilocularis flap endonuclease 1 0.0022 0.0049 0.0049
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.054 0.3006 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0018 0.009
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Loa Loa (eye worm) CXXC zinc finger family protein 0.0098 0.0482 0.2353
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0102 0.0203
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0023 0.0053 0.0176
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0364 0.1204
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0212 0.1137 0.2759
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Loa Loa (eye worm) flap endonuclease-1 0.0022 0.0049 0.0239
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus multilocularis cpg binding protein 0.0103 0.0514 0.0514
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0125 0.0637 0.1274
Onchocerca volvulus 0.0105 0.0524 0.2175
Echinococcus multilocularis Niemann Pick C1 protein 0.0209 0.1118 0.1118
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0581 0.1411
Echinococcus granulosus flap endonuclease 1 0.0022 0.0049 0.0119
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0053 0.0167
Plasmodium falciparum transporter, putative 0.0019 0.003 0.0925
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0102 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0003 0.0006
Schistosoma mansoni lamin 0.0028 0.0085 0.0206
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0099 0.0489 0.4921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0285 0.0571
Toxoplasma gondii hypothetical protein 0.0019 0.003 0.0299
Echinococcus multilocularis musashi 0.0028 0.0085 0.0085
Loa Loa (eye worm) pyruvate kinase 0.007 0.0321 0.1564
Brugia malayi beta-lactamase 0.0028 0.0081 0.0394
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Schistosoma mansoni hypothetical protein 0.0055 0.0235 0.0571
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0581 0.1411
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0031 0.0102 0.1023
Brugia malayi mbt repeat family protein 0.0045 0.0183 0.0893
Trypanosoma brucei PAB1-binding protein , putative 0.004 0.0153 0.0307
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0489 0.1626
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0097 0.0477 0.1588
Trypanosoma brucei pyruvate kinase 1 0.007 0.0321 0.0641
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0038 0.0143 0.07
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Echinococcus granulosus microtubule associated protein 2 0.0582 0.3249 0.7886
Echinococcus multilocularis Niemann Pick C1 protein 0.0299 0.1631 0.1631
Schistosoma mansoni chromosome transmission fidelity factor 0.0031 0.0102 0.0247
Plasmodium falciparum DNA repair protein REV1, putative 0.0014 0.0003 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.002 0.0049
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0081 0.0196
Echinococcus granulosus dual specificity 0.0102 0.0509 0.1235
Treponema pallidum exodeoxyribonuclease (exoA) 0.0032 0.0107 0.0114
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.0031 0.0102 0.0203
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0003 0.0006
Giardia lamblia Kinase, PLK 0.008 0.0382 1
Loa Loa (eye worm) norepinephrine transporter 0.0109 0.0549 0.2679
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0321 0.0641
Echinococcus granulosus pyruvate kinase 0.007 0.0321 0.0778
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0023 0.0053 0.0176
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Toxoplasma gondii ABC1 family protein 0.0028 0.0081 0.0813
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0045 0.0179 0.0874
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.0049
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0132 0.0263
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus granulosus serine:threonine protein kinase PLK1 0.008 0.0382 0.0926
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Mycobacterium tuberculosis Conserved protein 0.0028 0.0081 0.0268
Mycobacterium tuberculosis Conserved hypothetical protein 0.0045 0.0179 0.0596
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0016 0.0038
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.003 0.0098 0.0983
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0003 0.0006
Schistosoma mansoni hypothetical protein 0.0026 0.0074 0.0179
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0045 0.0179 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0131 0.0262
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0019 0.003 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Trypanosoma cruzi hypothetical protein, conserved 0.0031 0.0102 0.0203
Trypanosoma cruzi FHA domain containing protein, putative 0.0031 0.0102 0.0203
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0028 0.0081 0.0259
Schistosoma mansoni hypothetical protein 0.0283 0.1538 0.3733
Trypanosoma cruzi DNA polymerase eta, putative 0.0035 0.0126 0.0251
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0018 0.0045
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Plasmodium vivax pyruvate kinase, putative 0.007 0.0321 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0017 0.002 0.002
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.003 0.003
Onchocerca volvulus 0.0023 0.0053 0.0149
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0032 0.0107 0.0355
Trichomonas vaginalis CAMK family protein kinase 0.004 0.0152 0.0585
Echinococcus multilocularis dna polymerase eta 0.0066 0.0302 0.0302
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.003 0.0072
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Plasmodium vivax SET domain protein, putative 0.0055 0.0239 0.7451
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0285 0.0571
Echinococcus granulosus expressed conserved protein 0.0196 0.1046 0.2538
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0023 0.0053 0.1651
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.0285 0.0571
Loa Loa (eye worm) blistered cuticle protein 3 0.0039 0.0146 0.0712
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0055 0.0239 0.058
Schistosoma mansoni DNA polymerase eta 0.0066 0.0302 0.0733
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0102 0.0369
Echinococcus multilocularis Regulator of G protein signaling 20 0.0016 0.0016 0.0016
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0023 0.0053 0.0167
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Entamoeba histolytica hypothetical protein 0.0102 0.0509 0.4474
Brugia malayi regulator of G-protein signaling rgs-7 0.0016 0.0016 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis esterase, putative 0.0028 0.0081 0.0279
Onchocerca volvulus 0.0019 0.003 0.0048
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Mycobacterium ulcerans aldehyde dehydrogenase 0.0097 0.0477 0.158
Trichomonas vaginalis pyruvate kinase, putative 0.007 0.0321 0.131
Mycobacterium ulcerans aldehyde dehydrogenase 0.0097 0.0477 0.158
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0032 0.0107 0.0107
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0032 0.0107 0.0213
Onchocerca volvulus 0.0019 0.003 0.0048
Loa Loa (eye worm) MBCTL1 0.0052 0.0219 0.1068
Entamoeba histolytica hypothetical protein 0.0031 0.0102 0.0778
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0017 0.002 0.0099
Brugia malayi PXA domain containing protein 0.0016 0.0016 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0098 0.0195
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0364 0.1055
Echinococcus granulosus sodium and chloride dependent glycine 0.0019 0.003 0.0072
Brugia malayi topoisomerase 0.0031 0.0102 0.0496
Plasmodium vivax ataxin-2 like protein, putative 0.004 0.0153 0.4785
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0364 0.0729
Leishmania major cathepsin L-like protease 0.0063 0.0285 0.0571
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0132 0.0263
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0052 0.0219 0.0219
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0016 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0081 0.0161
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.0382 0.0764
Leishmania major hypothetical protein, conserved 0.004 0.0153 0.0307
Echinococcus granulosus SAM and MBT domain containing protein 0.0045 0.0183 0.0444
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0016 0.0038
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0081 0.0279
Mycobacterium tuberculosis Conserved protein 0.0028 0.0081 0.0268
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0156 0.0156
Schistosoma mansoni alpha-glucosidase 0.0118 0.0599 0.1455
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0018 0.0574
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Brugia malayi hypothetical protein 0.0019 0.003 0.0145
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Leishmania major alpha glucosidase II subunit, putative 0.003 0.0098 0.0195
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0097 0.0477 0.0955
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0018 0.0045
Loa Loa (eye worm) mbt repeat family protein 0.0045 0.0183 0.0893
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0018 0.0011
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.005 0.0211 0.0422
Onchocerca volvulus 0.0423 0.2342 1
Trypanosoma brucei pyruvate kinase 1, putative 0.007 0.0321 0.0641
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0099 0.0489 0.1618
Schistosoma mansoni DNA polymerase IV / kappa 0.0014 0.0003 0.0007
Schistosoma mansoni ap endonuclease 0.0032 0.0107 0.0259
Loa Loa (eye worm) hypothetical protein 0.0109 0.0549 0.2679
Echinococcus granulosus geminin 0.0594 0.3317 0.805
Brugia malayi Protein kinase domain containing protein 0.0102 0.0509 0.2483
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0072
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Loa Loa (eye worm) RGS-3 protein 0.0016 0.0016 0.0077
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0028 0.0081 0.0394
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0209 0.1118 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0055 0.0239 0.058
Mycobacterium ulcerans esterase/lipase LipP 0.0028 0.0081 0.0259
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.042 0.2325 0.4652
Loa Loa (eye worm) hypothetical protein 0.0109 0.0549 0.2679
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0209 0.112 0.2718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Onchocerca volvulus 0.0039 0.0146 0.0549
Leishmania major serine/threonine-protein kinase, putative,protein kinase, putative 0.0102 0.0509 0.1018
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0888 0.4998 1
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Echinococcus granulosus pyruvate kinase 0.0036 0.0127 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus granulosus cathepsin l1 0.0017 0.0018 0.0045
Plasmodium vivax pyruvate kinase 2, putative 0.0036 0.0127 0.397
Onchocerca volvulus 0.0019 0.003 0.0048
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Trichomonas vaginalis conserved hypothetical protein 0.009 0.0436 0.1807
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0364 0.1778
Chlamydia trachomatis pyruvate kinase 0.007 0.0321 1
Mycobacterium ulcerans acetyl-CoA synthetase 0.0023 0.0053 0.0167
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Schistosoma mansoni hypothetical protein 0.0041 0.0156 0.0379
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0032 0.0107 0.0213
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Onchocerca volvulus 0.0028 0.0085 0.0287
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Mycobacterium ulcerans hypothetical protein 0.0028 0.0081 0.0259
Onchocerca volvulus Serine\/threonine kinase homolog 0.008 0.0382 0.1564
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0019 0.0035 0.0349
Trypanosoma brucei CMGC/DYRK protein kinase, putative 0.0102 0.0509 0.1018
Loa Loa (eye worm) oxidoreductase 0.0023 0.0053 0.0258
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.0031 0.0102 0.0778
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Brugia malayi Pax transcription activation domain interacting protein 0.0031 0.0102 0.0496
Brugia malayi pyruvate kinase, muscle isozyme 0.0015 0.0007 0.0035
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0032 0.0107 0.0346
Echinococcus granulosus histone lysine methyltransferase setb 0.0055 0.0239 0.058
Entamoeba histolytica serine/threonine protein kinase, putative 0.008 0.0382 0.3319
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Mycobacterium ulcerans hypothetical protein 0.0099 0.0489 0.1618
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0098 0.0742
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Echinococcus multilocularis expressed conserved protein 0.0196 0.1046 0.1046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Loa Loa (eye worm) hypothetical protein 0.0109 0.0549 0.2679
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.005 0.0211 0.0702
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0364 0.1778
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0018 0.0037
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0032 0.0107 0.0259
Loa Loa (eye worm) hypothetical protein 0.0055 0.0239 0.1165
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0018 0.0018
Echinococcus multilocularis nibrin 0.0031 0.0102 0.0102
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Echinococcus multilocularis pyruvate kinase 0.0036 0.0127 0.0127
Schistosoma mansoni sex comb on midleg homolog 0.0045 0.0183 0.0444
Brugia malayi exodeoxyribonuclease III family protein 0.0032 0.0107 0.0521
Plasmodium vivax acetyl-CoA synthetase, putative 0.0023 0.0053 0.1651
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.0034 0.0083
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.0153 0.0307
Schistosoma mansoni cellular tumor antigen P53 0.0105 0.0524 0.1271
Echinococcus multilocularis lamin 0.0028 0.0085 0.0085
Echinococcus granulosus dna polymerase kappa 0.0067 0.0307 0.0746
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0045 0.0183 0.0444
Echinococcus multilocularis cysteine protease 0.0017 0.0018 0.0018
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0081 0.0094
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Loa Loa (eye worm) hypothetical protein 0.0028 0.0085 0.0415
Brugia malayi ImpB/MucB/SamB family protein 0.0045 0.0179 0.0874
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0081 0.0279
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0058 0.0253 0.0841
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0085 0.0415
Toxoplasma gondii LsmAD domain-containing protein 0.004 0.0153 0.1545
Mycobacterium ulcerans beta-lactamase 0.0028 0.0081 0.0259
Onchocerca volvulus 0.0055 0.0239 0.0949
Echinococcus multilocularis axis inhibition protein axin 0.0016 0.0016 0.0016
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0022 0.0049 0.0098
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.0031 0.0102 0.0496
Schistosoma mansoni topbp1 0.0031 0.0102 0.0247
Schistosoma mansoni sodium/chloride dependent transporter 0.0019 0.003 0.0072
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0022 0.005 0.0147
Onchocerca volvulus 0.0079 0.0378 0.1546
Brugia malayi Flap endonuclease-1 0.0022 0.0049 0.0239
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Echinococcus multilocularis polycomb protein SCMH1 0.0045 0.0183 0.0183
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0023 0.0053 0.0128
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0022 0.0049 0.0098
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0016 0.0016 0.0038
Echinococcus granulosus beta LACTamase domain containing family member 0.0028 0.0081 0.0196
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0085 0.0415
Trypanosoma cruzi major cysteine proteinase, putative 0.005 0.0208 0.0416
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.002 0.0049
Trypanosoma brucei glucosidase, putative 0.003 0.0098 0.0195
Trichomonas vaginalis replication factor C large subunit, putative 0.0031 0.0102 0.0369
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0081 0.2518
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Mycobacterium tuberculosis Probable hydrolase 0.0028 0.0081 0.0268
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0077 0.0364 0.1204
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0023 0.0053 0.0167
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0018 0.0574
Onchocerca volvulus 0.0028 0.0085 0.0287
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.1778
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0073 0.0178
Leishmania major acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Mycobacterium leprae Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.054 0.3006 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0028 0.0081 0.0268
Loa Loa (eye worm) hypothetical protein 0.0052 0.0219 0.1068
Brugia malayi Glycosyl hydrolases family 31 protein 0.0137 0.0709 0.3457
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Schistosoma mansoni axis inhibition protein axin 0.0016 0.0016 0.0038
Echinococcus granulosus lamin dm0 0.0028 0.0085 0.0206
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0098 0.0742
Loa Loa (eye worm) hypothetical protein 0.004 0.0153 0.0748
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.0307 0.1014
Schistosoma mansoni hypothetical protein 0.0594 0.3317 0.805
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0081 0.0161
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.0031 0.0102 0.0329
Schistosoma mansoni aldehyde dehydrogenase 0.0097 0.0477 0.1159
Loa Loa (eye worm) hypothetical protein 0.0105 0.0524 0.2555
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Brugia malayi A-kinase anchor protein 10, precursor 0.0016 0.0016 0.0077
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0058 0.0253 0.7675
Echinococcus granulosus sterol regulatory element binding protein 0.009 0.0436 0.1059
Loa Loa (eye worm) MH2 domain-containing protein 0.0135 0.0695 0.3392
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0018 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Schistosoma mansoni alpha glucosidase 0.003 0.0098 0.0237
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0364 0.1204
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0072
Trypanosoma brucei DNA polymerase IV, putative 0.0067 0.0307 0.0615
Mycobacterium tuberculosis Conserved hypothetical protein 0.0468 0.2597 0.8638
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.003 0.0098 0.0477
Brugia malayi hypothetical protein 0.0026 0.0072 0.0351
Mycobacterium ulcerans DNA polymerase IV 0.0067 0.0307 0.1014
Giardia lamblia DINP protein human, muc B family 0.005 0.0211 0.5495
Onchocerca volvulus 0.0028 0.0081 0.0268
Echinococcus multilocularis lysosomal alpha glucosidase 0.0137 0.0709 0.0709
Loa Loa (eye worm) hypothetical protein 0.0102 0.0504 0.2462
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0032 0.0107 0.0107
Toxoplasma gondii exonuclease III APE 0.0032 0.0107 0.1074
Leishmania major DNA damage repair protein, putative 0.0014 0.0003 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0032 0.0107 0.3329
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Echinococcus multilocularis serotonin transporter 0.0109 0.0549 0.0549
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0045 0.0183 0.0708
Mycobacterium ulcerans lipase LipD 0.0028 0.0081 0.0259
Echinococcus granulosus lamin 0.0028 0.0085 0.0206
Mycobacterium leprae Probable pyruvate kinase PykA 0.007 0.0321 0.0906
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0115 0.0581 0.0581
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0018 0.0045
Loa Loa (eye worm) hypothetical protein 0.0113 0.0566 0.2763
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Mycobacterium tuberculosis Conserved protein 0.0028 0.0081 0.0268
Loa Loa (eye worm) hypothetical protein 0.0028 0.0081 0.0394
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0258
Schistosoma mansoni survival motor neuron protein 0.0055 0.0235 0.0571
Echinococcus granulosus Protein patched homolog 1 0.009 0.0436 0.1059
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0019 0.003 0.0072
Plasmodium falciparum pyruvate kinase 0.007 0.0321 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0077 0.0364 0.1204
Echinococcus granulosus pyruvate kinase 0.0036 0.0127 0.0309
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.054 0.3006 1
Brugia malayi Pyruvate kinase, M2 isozyme 0.007 0.0321 0.1564
Toxoplasma gondii aldehyde dehydrogenase 0.0097 0.0477 0.4807
Plasmodium falciparum amino acid transporter, putative 0.0019 0.003 0.0925
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0016 0.0077
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.005 0.0147
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0032 0.0107 0.0213
Trichomonas vaginalis helicase, putative 0.0022 0.005 0.0147
Echinococcus granulosus peroxidasin 0.0039 0.0146 0.0354
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0115 0.0581 0.0581
Loa Loa (eye worm) ctsf protein 0.0017 0.0018 0.009
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0073 0.0073
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0299
Trypanosoma brucei DNA polymerase kappa, putative 0.005 0.0211 0.0422
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0053 0.0176
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0115 0.0581 0.1411
Schistosoma mansoni pyruvate kinase 0.007 0.0321 0.0778
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0023 0.0053 0.0176
Echinococcus multilocularis pyruvate kinase 0.0055 0.0237 0.0237
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0018 0.0027 0.0065
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0109 0.0549 0.1333
Onchocerca volvulus 0.0023 0.0053 0.0149
Schistosoma mansoni hypothetical protein 0.0594 0.3317 0.805
Loa Loa (eye worm) pyruvate kinase 0.007 0.0321 0.1564
Brugia malayi Muscleblind-like protein 0.0113 0.0566 0.2763
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0185 0.0983 0.2386
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0098 0.0352
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0018 0.0574
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Loa Loa (eye worm) transcription factor SMAD2 0.0135 0.0695 0.3392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Loa Loa (eye worm) solute carrier family 6 member 4 0.0109 0.0549 0.2679
Echinococcus multilocularis pyruvate kinase 0.0036 0.0127 0.0127
Toxoplasma gondii histone lysine methyltransferase SET1 0.0187 0.0993 1
Loa Loa (eye worm) hypothetical protein 0.011 0.0551 0.2691
Schistosoma mansoni cpg binding protein 0.0103 0.0514 0.1248
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.007 0.0321 0.1066
Brugia malayi hypothetical protein 0.0031 0.0102 0.0496
Plasmodium vivax acyl-CoA synthetase, putative 0.0058 0.0253 0.789
Brugia malayi hypothetical protein 0.0268 0.1452 0.7085
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Echinococcus granulosus tumor protein p63 0.0718 0.4024 0.9766
Echinococcus multilocularis pyruvate kinase 0.0036 0.0127 0.0127
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0125 0.0637 0.1274
Schistosoma mansoni cpg binding protein 0.0098 0.0482 0.117
Trypanosoma brucei unspecified product 0.0031 0.01 0.02
Toxoplasma gondii hypothetical protein 0.0019 0.003 0.0299
Schistosoma mansoni microtubule-associated protein tau 0.0582 0.3249 0.7886
Brugia malayi pyruvate kinase 0.0015 0.0007 0.0035
Toxoplasma gondii pyruvate kinase PyK1 0.007 0.0321 0.3228
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Brugia malayi hypothetical protein 0.0016 0.0016 0.0077
Trypanosoma cruzi polo-like protein kinase, putative 0.008 0.0382 0.0764
Echinococcus granulosus nibrin 0.0031 0.0102 0.0247
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0058 0.0253 0.0833
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Schistosoma mansoni intermediate filament proteins 0.0028 0.0085 0.0206
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0019 0.003 0.0072
Onchocerca volvulus 0.0098 0.0482 0.1996
Echinococcus multilocularis protein patched 0.009 0.0436 0.0436
Schistosoma mansoni topbp1 0.0031 0.0102 0.0247
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0018 0.0018
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Trypanosoma brucei unspecified product 0.0062 0.0276 0.0551
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Brugia malayi hypothetical protein 0.0031 0.0102 0.0496
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0001 0.0003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Trichomonas vaginalis ap endonuclease, putative 0.0032 0.0107 0.0391
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0085 0.0415
Treponema pallidum sodium- and chloride- dependent transporter 0.0109 0.0549 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0028 0.0081 0.0279
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0115 0.0581 0.1411
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0016 0.0016 0.0038
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0018 0.0023
Onchocerca volvulus 0.0023 0.0053 0.0149
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0146 0.0549
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Echinococcus multilocularis regulator of G protein signaling 3 0.0016 0.0016 0.0016
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Mycobacterium ulcerans hypothetical protein 0.0077 0.0364 0.1204
Entamoeba histolytica cysteine protease, putative 0.0017 0.0018 0.0023
Giardia lamblia Replication factor C, subunit 1 0.0031 0.0102 0.2608
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0016 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Echinococcus multilocularis pyruvate kinase 0.007 0.0321 0.0321
Giardia lamblia Pyruvate kinase 0.0036 0.0127 0.3285
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0137 0.0709 0.3457
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0098 0.0477
Echinococcus multilocularis lamin dm0 0.0028 0.0085 0.0085
Echinococcus granulosus muscleblind protein 0.0113 0.0566 0.1375
Plasmodium vivax DNA repair protein REV1, putative 0.0014 0.0003 0.0088
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Brugia malayi AMP-binding enzyme family protein 0.0077 0.0364 0.1778
Schistosoma mansoni patched 1 0.009 0.0436 0.1059
Brugia malayi latrophilin 2 splice variant baaae 0.0026 0.0074 0.036
Loa Loa (eye worm) hypothetical protein 0.0038 0.0143 0.07
Loa Loa (eye worm) pyruvate kinase 0.0015 0.0007 0.0035
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.0031 0.0102 0.0369
Schistosoma mansoni lamin 0.0028 0.0085 0.0206
Toxoplasma gondii hypothetical protein 0.0143 0.0742 0.7471
Echinococcus multilocularis beta LACTamase domain containing family member 0.0028 0.0081 0.0081
Brugia malayi Niemann-Pick C1 protein precursor 0.0209 0.1118 0.5455
Trypanosoma cruzi pyruvate kinase 2, putative 0.007 0.0321 0.0641
Schistosoma mansoni sodium-dependent amino acid transporter 0.0019 0.003 0.0072
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0109 0.0549 0.2679
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0115 0.0581 0.1411
Trichomonas vaginalis flap endonuclease-1, putative 0.0022 0.0049 0.0142
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0321 0.1301
Leishmania major cathepsin L-like protease 0.0063 0.0285 0.0571
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0022 0.005 0.0147
Loa Loa (eye worm) hypothetical protein 0.0113 0.0566 0.2763
Trichomonas vaginalis DNA polymerase eta, putative 0.0067 0.0307 0.1253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Brugia malayi hypothetical protein 0.0041 0.0156 0.0761
Schistosoma mansoni cpg binding protein 0.0103 0.0514 0.1248
Onchocerca volvulus Pyruvate kinase homolog 0.007 0.0321 0.1301
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0019 0.003 0.0072
Brugia malayi polk-prov protein 0.0036 0.0131 0.0639
Mycobacterium tuberculosis Conserved hypothetical protein 0.0099 0.0489 0.1626
Onchocerca volvulus 0.0028 0.0081 0.0268
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0018 0.009
Echinococcus granulosus expressed protein 0.0315 0.1722 0.418
Mycobacterium ulcerans acyl-CoA synthetase 0.0077 0.0364 0.1204
Brugia malayi PXA domain containing protein 0.0016 0.0016 0.0077
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0032 0.0107 0.0261
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Trichomonas vaginalis sucrase-isomaltase, putative 0.003 0.0098 0.0352
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Echinococcus multilocularis protein dispatched 1 0.0102 0.0509 0.0509
Echinococcus granulosus Niemann Pick C1 protein 0.0209 0.1118 0.2714
Echinococcus multilocularis sodium and chloride dependent glycine 0.0019 0.003 0.003
Echinococcus multilocularis pyruvate kinase 0.007 0.0321 0.0321
Onchocerca volvulus Dual oxidase homolog 0.0039 0.0146 0.0549
Echinococcus granulosus neutral alpha glucosidase AB 0.003 0.0098 0.0237
Plasmodium falciparum acyl-CoA synthetase 0.0058 0.0253 0.789
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0077 0.0364 0.1055
Plasmodium vivax replication factor C subunit 1, putative 0.0031 0.0102 0.317
Loa Loa (eye worm) PXA domain-containing protein 0.0016 0.0016 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Echinococcus granulosus lysosomal alpha glucosidase 0.0137 0.0709 0.172
Brugia malayi beta-lactamase family protein 0.0028 0.0081 0.0394
Plasmodium vivax flap endonuclease 1, putative 0.0022 0.0049 0.1527
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0001 0.0001
Schistosoma mansoni alpha-glucosidase 0.0118 0.0599 0.1455
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0032 0.0107 0.0521
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0156 0.0379
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0018 0.0023
Trichomonas vaginalis CAMK family protein kinase 0.008 0.0382 0.1573
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Entamoeba histolytica deoxycytidyl transferase, putative 0.0045 0.0179 0.1482
Chlamydia trachomatis DNA ligase 0.0031 0.0102 0.2473
Trichomonas vaginalis D-aminoacylase, putative 0.0028 0.0081 0.0279
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0032 0.0107 0.2742
Schistosoma mansoni peroxidasin 0.0039 0.0146 0.0354
Echinococcus granulosus cpg binding protein 0.0103 0.0514 0.1248
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0019 0.003 0.0072
Schistosoma mansoni kinase 0.0041 0.0158 0.0383
Schistosoma mansoni acetyl-CoA synthetase 0.0023 0.0053 0.0128
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0888 0.4998 1
Echinococcus granulosus polycomb protein SCMH1 0.0045 0.0183 0.0444
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0023 0.0053 0.0258
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0299
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Echinococcus multilocularis histone acetyltransferase MYST2 0.0052 0.0219 0.0219
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0098 0.0352
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0098 0.0352
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Echinococcus granulosus replication factor c subunit 1 0.0031 0.0102 0.0247
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0018 0.0018
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0364 0.3162
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0098 0.0195
Trypanosoma cruzi hypothetical protein, conserved 0.0014 0.0003 0.0006
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.001 0.0049
Toxoplasma gondii propionate-CoA ligase 0.0023 0.0053 0.0533
Toxoplasma gondii cathepsin CPL 0.0017 0.0018 0.0185
Onchocerca volvulus 0.0055 0.0235 0.0933
Onchocerca volvulus 0.0028 0.0081 0.0268
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0364 0.0729
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.0285 0.0571
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.0031 0.0102 0.0369
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0055 0.0235 0.1148
Echinococcus multilocularis peroxidasin 0.0039 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0102 0.0504 0.2462
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0038 0.0143 0.07
Loa Loa (eye worm) animal heme peroxidase 0.0039 0.0146 0.0712
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0115 0.0581 0.2836
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0023 0.0053 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0077 0.0364 0.0729
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0023 0.0053 0.0167
Schistosoma mansoni aldehyde dehydrogenase 0.0097 0.0477 0.1159
Loa Loa (eye worm) hypothetical protein 0.0209 0.1118 0.5455
Leishmania major DNA polymerase kappa, putative 0.005 0.0211 0.0422
Brugia malayi mbt repeat family protein 0.0045 0.0183 0.0893
Echinococcus multilocularis geminin 0.0594 0.3317 0.3317
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus multilocularis muscleblind protein 0.0113 0.0566 0.0566
Echinococcus multilocularis dual specificity 0.0102 0.0509 0.0509
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Loa Loa (eye worm) beta-lactamase 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Echinococcus granulosus pyruvate kinase 0.0036 0.0127 0.0309
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Plasmodium falciparum pyruvate kinase 2 0.0036 0.0127 0.397
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0077 0.0364 0.1204
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0145
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0145
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0077 0.0364 0.1212
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0102 0.0369
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0019 0.003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0058 0.0253 0.1234
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Loa Loa (eye worm) CMGC/DYRK/DYRK1 protein kinase 0.0102 0.0509 0.2483
Echinococcus granulosus serotonin transporter 0.0109 0.0549 0.1333
Brugia malayi Regulator of G protein signaling domain containing protein 0.0016 0.0016 0.0077
Schistosoma mansoni peroxidasin 0.0039 0.0146 0.0354
Trypanosoma brucei hypothetical protein, conserved 0.0014 0.0003 0.0006
Giardia lamblia Pyruvate kinase 0.007 0.0321 0.8387
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0019 0.003 0.0299
Mycobacterium tuberculosis Probable lipase LipD 0.0028 0.0081 0.0268
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0028 0.0081 0.0196
Onchocerca volvulus Peroxidasin homolog 0.0039 0.0146 0.0549
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0019 0.003 0.003
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0023 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0055 0.0239 0.2405
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Trypanosoma cruzi PAB1-binding protein , putative 0.004 0.0153 0.0307
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0016 0.0038
Leishmania major DNA polymerase eta, putative 0.0035 0.0126 0.0251
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Schistosoma mansoni hypothetical protein 0.0086 0.0418 0.1014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Entamoeba histolytica hypothetical protein 0.0041 0.0156 0.1272
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.042 0.2325 0.4652
Schistosoma mansoni flap endonuclease-1 0.002 0.0037 0.009
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Plasmodium falciparum ataxin-2 like protein, putative 0.004 0.0153 0.4785
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0176 0.0928 0.3088
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0028 0.0081 0.0394
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.1778
Entamoeba histolytica protein kinase, putative 0.0102 0.0509 0.4474
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0023 0.0053 0.0533
Echinococcus multilocularis survival motor neuron protein 1 0.0268 0.1452 0.1452
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0032 0.0107 0.0825
Schistosoma mansoni myelin transcription factor 1 myt1 0.0052 0.0219 0.0531
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.054 0.3006 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0038 0.0143 0.07
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0097 0.0477 0.1159
Loa Loa (eye worm) hypothetical protein 0.0066 0.0302 0.1473
Echinococcus granulosus dnaJ subfamily B 0.0734 0.412 1
Mycobacterium leprae Probable lipase LipE 0.0028 0.0081 0.0094
Leishmania major hypothetical protein, conserved 0.0028 0.0081 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Echinococcus granulosus histone acetyltransferase MYST2 0.0052 0.0219 0.0531
Plasmodium vivax vivapain-2 0.0017 0.0018 0.0574
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Loa Loa (eye worm) fibroinase 0.0017 0.0018 0.009
Schistosoma mansoni pyruvate kinase 0.007 0.0321 0.0778
Loa Loa (eye worm) hypothetical protein 0.0023 0.0053 0.0258
Loa Loa (eye worm) histone methyltransferase 0.0032 0.0107 0.0524
Trichomonas vaginalis set domain proteins, putative 0.0423 0.2342 1
Echinococcus multilocularis microtubule associated protein 2 0.0582 0.3249 0.3249
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0016 0.0016
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0018 0.0018
Treponema pallidum licC protein (licC) 0.0099 0.0489 0.8651
Mycobacterium ulcerans pyruvate kinase 0.007 0.0321 0.1058
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0098 0.0352
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.008 0.0382 0.1862
Toxoplasma gondii pyruvate kinase PyKII 0.0036 0.0127 0.1282
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Trypanosoma brucei polo-like protein kinase 0.008 0.0382 0.0764
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0055 0.0235 0.0781
Plasmodium vivax amine transporter, putative 0.0019 0.003 0.0925
Plasmodium falciparum replication factor C subunit 1, putative 0.0031 0.0102 0.317
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.0285 0.0571
Loa Loa (eye worm) hypothetical protein 0.0268 0.1452 0.7085
Echinococcus granulosus intermediate filament protein 0.0028 0.0085 0.0206
Onchocerca volvulus 0.0023 0.0053 0.0149
Loa Loa (eye worm) hypothetical protein 0.0014 0.0001 0.0007
Onchocerca volvulus 0.0109 0.0549 0.2284
Echinococcus granulosus beta-adrenergic receptor kinase 0.0017 0.002 0.0049
Leishmania major DNA polymerase eta, putative 0.0066 0.0302 0.0604
Leishmania major cathepsin L-like protease 0.0017 0.0018 0.0037
Schistosoma mansoni pyruvate kinase 0.0036 0.0127 0.0309
Schistosoma mansoni sodium/chloride dependent transporter 0.0109 0.0549 0.1333
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0023 0.0053 0.0106
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0052 0.0219 0.1068
Loa Loa (eye worm) hypothetical protein 0.0031 0.0102 0.0496
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0023 0.0053 0.0533
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0052 0.0219 0.0531
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Entamoeba histolytica acyl-CoA synthetase, putative 0.0077 0.0364 0.3162
Brugia malayi MH2 domain containing protein 0.0135 0.0695 0.3392
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0032 0.0107 0.0018
Entamoeba histolytica Flap nuclease, putative 0.0022 0.0049 0.03
Echinococcus granulosus regulator of G protein signaling 3 0.0016 0.0016 0.0038
Brugia malayi hypothetical protein 0.0039 0.0146 0.0712
Brugia malayi hypothetical protein 0.0016 0.0016 0.0077
Brugia malayi CXXC zinc finger family protein 0.0098 0.0482 0.2353
Echinococcus multilocularis cysteine protease 0.0017 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.007 0.0321 0.1564
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0016 0.0038
Brugia malayi serine/threonine-protein kinase plk-2 0.008 0.0382 0.1862
Loa Loa (eye worm) hypothetical protein 0.0017 0.0018 0.009
Brugia malayi Cathepsin L-like precursor 0.0017 0.0018 0.009
Onchocerca volvulus Chorion peroxidase homolog 0.0039 0.0146 0.0549
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0003 0.0006
Echinococcus granulosus Niemann Pick C1 protein 0.0299 0.1631 0.3958
Echinococcus granulosus axis inhibition protein axin 0.0016 0.0016 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0053 0.0258
Trypanosoma cruzi DNA damage repair protein, putative 0.0014 0.0003 0.0006
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Schistosoma mansoni ap endonuclease 0.0032 0.0107 0.0259
Leishmania major pyruvate kinase 0.007 0.0321 0.0641
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.042 0.2325 0.4652
Mycobacterium ulcerans hypothetical protein 0.0099 0.0489 0.1618
Giardia lamblia Flap structure-specific endonuclease 0.0022 0.0049 0.1217
Leishmania major DNA polymerase kappa, putative 0.0014 0.0003 0.0006
Echinococcus granulosus Regulator of G protein signaling 20 0.0016 0.0016 0.0038
Echinococcus multilocularis lysosomal alpha glucosidase 0.0137 0.0709 0.0709
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0055 0.0239 0.0239
Trypanosoma brucei DNA damage repair protein, putative 0.0014 0.0003 0.0006
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0032 0.0107 0.3329
Loa Loa (eye worm) hypothetical protein 0.0039 0.0146 0.0712
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0023 0.0053 0.0176
Loa Loa (eye worm) cysteine protease 0.0017 0.0018 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0132 0.0263
Loa Loa (eye worm) serotonin transporter b 0.0109 0.0549 0.2679
Echinococcus multilocularis regulator of G protein signaling 0.0016 0.0016 0.0016
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0115 0.0581 0.2836
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0019 0.003 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.005 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0018 0.0011
Echinococcus multilocularis expressed protein 0.0315 0.1722 0.1722
Toxoplasma gondii ATPase, AAA family protein 0.0031 0.0102 0.1023
Trypanosoma brucei DNA polymerase kappa, putative 0.0067 0.0307 0.0615
Loa Loa (eye worm) hypothetical protein 0.0045 0.0183 0.0893
Brugia malayi Animal haem peroxidase family protein 0.0039 0.0146 0.0712
Onchocerca volvulus 0.0031 0.0102 0.0358
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0105 0.0514
Brugia malayi hypothetical protein 0.004 0.0153 0.0748
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0073 0.0073
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0022 0.0049 0.0493
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0019 0.003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0077 0.0364 0.1778
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0152 0.0793 0.1587
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0018 0.009
Trypanosoma cruzi CMGC/DYRK protein kinase, putative 0.0102 0.0509 0.1018
Echinococcus granulosus pyruvate kinase 0.007 0.0321 0.0778
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0053 0.0167

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 12.856 uM Agonist activity at rat DAT expressed in CHO cells ChEMBL. 20971650

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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