Detailed information for compound 1217589

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 570.615 | Formula: C33H35N2O5P
  • H donors: 4 H acceptors: 5 LogP: 2.24 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C([C@@H](CP(=O)(C(Cc1ccccc1)N)O)Cc1ccccc1)N[C@H](C(=O)O)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C33H35N2O5P/c34-31(22-25-12-6-2-7-13-25)41(39,40)23-29(20-24-10-4-1-5-11-24)32(36)35-30(33(37)38)21-26-16-18-28(19-17-26)27-14-8-3-9-15-27/h1-19,29-31H,20-23,34H2,(H,35,36)(H,37,38)(H,39,40)/t29-,30+,31?/m1/s1
  • InChiKey: QPOVWWCINWTVIO-AWZUCMKVSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Oryctolagus cuniculus Neprilysin Starlite/ChEMBL References
Sus scrofa Aminopeptidase N Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Toxoplasma gondii peptidase family M13 protein Get druggable targets OG5_127344 All targets in OG5_127344
Neospora caninum hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum IPR000718,Peptidase M13, neprilysin,domain-containing Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium leprae probable zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127217 All targets in OG5_127217
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma japonicum ko:K01256 membrane alanyl aminopeptidase [EC3.4.11.2], putative Get druggable targets OG5_127217 All targets in OG5_127217
Echinococcus granulosus aminopeptidase N Get druggable targets OG5_127217 All targets in OG5_127217
Schistosoma japonicum ko:K01415 endothelin-converting enzyme [EC3.4.24.71], putative Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Schistosoma mansoni family M13 unassigned peptidase (M13 family) Get druggable targets OG5_127344 All targets in OG5_127344
Onchocerca volvulus Get druggable targets OG5_127344 All targets in OG5_127344
Brugia malayi Peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127217 All targets in OG5_127217
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127217 All targets in OG5_127217
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) peptidase family M1 containing protein Get druggable targets OG5_127217 All targets in OG5_127217
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Mycobacterium ulcerans zinc metalloprotease Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis endothelin converting enzyme 1 Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
Echinococcus multilocularis aminopeptidase N Get druggable targets OG5_127217 All targets in OG5_127217
Brugia malayi Peptidase family M1 containing protein Get druggable targets OG5_127217 All targets in OG5_127217
Loa Loa (eye worm) peptidase family M13 containing protein Get druggable targets OG5_127344 All targets in OG5_127344
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127344 All targets in OG5_127344
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma japonicum Endothelin-converting enzyme 2, putative Neprilysin   750 aa 787 aa 21.2 %
Echinococcus multilocularis puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 981 aa 28.8 %
Onchocerca volvulus Aminopeptidase N   963 aa 893 aa 32.0 %
Echinococcus multilocularis puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 981 aa 29.2 %
Onchocerca volvulus Neprilysin   750 aa 682 aa 31.4 %
Echinococcus granulosus puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 975 aa 29.1 %
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) Neprilysin   750 aa 773 aa 20.7 %
Echinococcus multilocularis puromycin sensitive aminopeptidase Aminopeptidase N   963 aa 988 aa 28.5 %
Onchocerca volvulus Neprilysin   750 aa 713 aa 33.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0135 0.0406 0.2337
Toxoplasma gondii exonuclease III APE 0.0057 0.0134 0.2003
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0007 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0084 0.0225 0.0225
Brugia malayi jmjC domain containing protein 0.0298 0.0973 0.252
Onchocerca volvulus Matrilysin homolog 0.0323 0.1061 0.2714
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Treponema pallidum sodium- and chloride- dependent transporter 0.1126 0.3861 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0068 0.0176
Toxoplasma gondii hypothetical protein 0.0191 0.0601 0.9302
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Loa Loa (eye worm) hypothetical protein 0.0145 0.044 0.1141
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0028 0.0211
Loa Loa (eye worm) peptidase family M1 containing protein 0.0116 0.0338 0.0875
Plasmodium falciparum thioredoxin reductase 0.0071 0.0181 0.2753
Echinococcus granulosus jumonji domain containing 1A 0.0077 0.0202 0.0202
Schistosoma mansoni sodium/chloride dependent transporter 0.0191 0.0601 0.0601
Toxoplasma gondii GAF domain-containing protein 0.0022 0.0011 0.0066
Schistosoma mansoni ap endonuclease 0.0057 0.0134 0.0134
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0394 0.1307 0.7523
Trichomonas vaginalis inositol monophosphatase, putative 0.0151 0.0461 0.1936
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0134 0.2562
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.0986 0.2553
Trichomonas vaginalis hypothetical protein 0.0024 0.0018 0.0077
Mycobacterium tuberculosis Probable reductase 0.0465 0.1556 0.8958
Echinococcus multilocularis tar DNA binding protein 0.0196 0.0617 0.0617
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0018 0.0077
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Echinococcus multilocularis microtubule associated protein 2 0.2886 1 1
Loa Loa (eye worm) hypothetical protein 0.0056 0.0131 0.034
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0222 0.0933
Toxoplasma gondii hypothetical protein 0.0061 0.0145 0.2172
Schistosoma mansoni laminin gamma-3 chain 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Echinococcus granulosus Smad4 0.0069 0.0176 0.0176
Brugia malayi GCC2 and GCC3 family protein 0.0034 0.0054 0.014
Onchocerca volvulus 0.0191 0.0601 0.1516
Onchocerca volvulus 0.0042 0.0081 0.0163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0084 0.0225 0.0225
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0202 0.0524
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0058 0.0135 0.0135
Loa Loa (eye worm) thioredoxin reductase 0.0204 0.0645 0.1671
Schistosoma mansoni hypothetical protein 0.0187 0.0585 0.0585
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0018 0.0347
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0192 0.0604 0.0604
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Echinococcus granulosus serotonin transporter 0.1126 0.3861 0.3861
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0054 0.0054
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0084 0.0225 0.3491
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0028 0.0428
Echinococcus multilocularis slit 2 protein 0.0034 0.0054 0.0054
Echinococcus multilocularis protein jagged 1 0.0034 0.0054 0.0054
Entamoeba histolytica hypothetical protein 0.015 0.0458 0.8719
Brugia malayi Valyl-tRNA synthetase 0.0024 0.0018 0.0047
Echinococcus multilocularis protein jagged 2 0.0034 0.0054 0.0054
Echinococcus granulosus chromobox protein 2 0.0024 0.0018 0.0018
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0071 0.0181 0.0181
Brugia malayi CXXC zinc finger family protein 0.003 0.004 0.0104
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0151 0.0461 0.3529
Onchocerca volvulus Chorion peroxidase homolog 0.0266 0.0862 0.2196
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0076
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0027 0.0029 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0018 0.0223
Schistosoma mansoni jumonji domain containing protein 0.0548 0.1846 0.1846
Schistosoma mansoni notch 0.0034 0.0054 0.0054
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0465 0.1556 0.8952
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.003 0.004 0.004
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Loa Loa (eye worm) animal heme peroxidase 0.0266 0.0862 0.2233
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0175 0.0734
Schistosoma mansoni peroxidasin 0.0266 0.0862 0.0862
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0067 0.0168 0.0168
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0024 0.0018 0.0223
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0084 0.0228 0.059
Loa Loa (eye worm) hypothetical protein 0.0086 0.0235 0.0608
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0323 0.1061 0.2749
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0028 0.0428
Loa Loa (eye worm) hypothetical protein 0.0883 0.3012 0.78
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0085 0.0231 0.0231
Echinococcus granulosus inositol monophosphatase 1 0.0151 0.0461 0.0461
Brugia malayi isocitrate dehydrogenase 0.0084 0.0225 0.0583
Loa Loa (eye worm) hypothetical protein 0.0028 0.0033 0.0084
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0151 0.0461 0.7149
Loa Loa (eye worm) MH2 domain-containing protein 0.1018 0.3485 0.9025
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0196 0.0617 0.1598
Loa Loa (eye worm) isocitrate dehydrogenase 0.0084 0.0225 0.0583
Schistosoma mansoni methyl-cpg binding protein mbd 0.007 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Plasmodium falciparum phd finger protein, putative 0.0187 0.0585 0.9068
Loa Loa (eye worm) ICD-1 protein 0.0034 0.0053 0.0137
Echinococcus granulosus polycomb protein SCMH1 0.0402 0.1335 0.1335
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Loa Loa (eye worm) hypothetical protein 0.0101 0.0286 0.0742
Echinococcus multilocularis inositol monophosphatase 1 0.0151 0.0461 0.0461
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0491 0.0491
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Brugia malayi jmjC domain containing protein 0.0077 0.0202 0.0524
Brugia malayi Animal haem peroxidase family protein 0.0266 0.0862 0.2233
Echinococcus granulosus mothers against decapentaplegic 6 0.0031 0.0042 0.0042
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0517 0.1737 1
Onchocerca volvulus Matrix metalloproteinase homolog 0.0717 0.2434 0.6287
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Schistosoma mansoni protein phosphatase 2C 0.0077 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Toxoplasma gondii NADPH-glutathione reductase 0.0071 0.0181 0.2723
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Brugia malayi Matrixin family protein 0.0323 0.1061 0.2749
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0042 0.0177
Brugia malayi Matrixin family protein 0.0323 0.1061 0.2749
Brugia malayi hypothetical protein 0.0042 0.0081 0.021
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0084 0.0225 0.3451
Echinococcus multilocularis sodium and chloride dependent glycine 0.0191 0.0601 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0138 0.058
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0072
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0017
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0034 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Schistosoma mansoni hypothetical protein 0.0067 0.0168 0.0168
Loa Loa (eye worm) hypothetical protein 0.0337 0.1109 0.2872
Trypanosoma brucei Aminopeptidase M1, putative 0.0042 0.0081 0.1255
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0042 0.0177
Echinococcus granulosus mothers against decapentaplegic 2 0.0031 0.0042 0.0042
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0145 0.061
Loa Loa (eye worm) MH2 domain-containing protein 0.0069 0.0176 0.0456
Schistosoma mansoni septate junction protein 0.0034 0.0054 0.0054
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0028 0.0098
Loa Loa (eye worm) MBCTL1 0.0457 0.1529 0.396
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0067 0.0168 0.0168
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0028 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0018 0.0018
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0071 0.0181 0.2798
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0024 0.0018 0.0018
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0034 0.0054 0.0054
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.015 0.0458 0.0458
Loa Loa (eye worm) hypothetical protein 0.0027 0.0029 0.0076
Schistosoma mansoni notch 0.0034 0.0054 0.0054
Loa Loa (eye worm) transcription factor SMAD2 0.1018 0.3485 0.9025
Trichomonas vaginalis conserved hypothetical protein 0.0059 0.0138 0.058
Brugia malayi TAR-binding protein 0.0196 0.0617 0.1598
Onchocerca volvulus Neurogenic locus notch homolog 0.0034 0.0054 0.0093
Echinococcus multilocularis mothers against decapentaplegic 5 0.0069 0.0176 0.0176
Loa Loa (eye worm) hypothetical protein 0.1126 0.3861 1
Echinococcus granulosus Chromobox protein 3 0.0024 0.0018 0.0018
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0517 0.1737 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.0487 0.1262
Trypanosoma cruzi Aminopeptidase M1, putative 0.0042 0.0081 0.1255
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0084 0.0225 0.0225
Echinococcus granulosus delta-like protein 1 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0019 0.0019
Loa Loa (eye worm) Smad1 0.0069 0.0176 0.0456
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0042 0.0177
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Schistosoma mansoni peroxidasin 0.0266 0.0862 0.0862
Echinococcus granulosus sodium and chloride dependent glycine 0.0191 0.0601 0.0601
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0181 0.1408
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0617 0.2086 0.5402
Echinococcus multilocularis SAM and MBT domain containing protein 0.0402 0.1335 0.1335
Schistosoma mansoni inositol monophosphatase 0.0151 0.0461 0.0461
Loa Loa (eye worm) blistered cuticle protein 3 0.0266 0.0862 0.2233
Loa Loa (eye worm) solute carrier family 6 member 4 0.1126 0.3861 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0212 0.0675 0.1748
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0054 0.0054
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Schistosoma mansoni hypothetical protein 0.0067 0.0168 0.0168
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0 0.0001
Echinococcus multilocularis neurogenic locus notch protein 4 0.0034 0.0054 0.0054
Echinococcus multilocularis smad 0.0069 0.0176 0.0176
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0168 0.0521 0.0521
Schistosoma mansoni alkaline phosphatase 0.0168 0.0521 0.0521
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.003 0.004 0.0169
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0042 0.0177
Brugia malayi F/Y-rich N-terminus family protein 0.0081 0.0218 0.0565
Plasmodium falciparum importin beta, putative 0.0028 0.0033 0.0446
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0175 0.271
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0024 0.0018 0.0223
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0038
Echinococcus multilocularis chromobox protein 1 0.0147 0.0448 0.0448
Echinococcus multilocularis notch 0.0034 0.0054 0.0054
Loa Loa (eye worm) aminopeptidase N 0.0042 0.0081 0.021
Echinococcus multilocularis mothers against decapentaplegic 6 0.0031 0.0042 0.0042
Echinococcus multilocularis neural cadherin 0.0034 0.0054 0.0054
Brugia malayi hypothetical protein 0.015 0.0458 0.1186
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Echinococcus granulosus slit 2 protein 0.0034 0.0054 0.0054
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0134 0.2084
Onchocerca volvulus Alhambra homolog 0.0187 0.0585 0.1476
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0033 0.0407
Schistosoma mansoni cpg binding protein 0.004 0.0074 0.0074
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.003 0.004 0.0169
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0134 0.2035
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Loa Loa (eye worm) latrophilin receptor protein 2 0.0067 0.0168 0.0436
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.0175 0.271
Loa Loa (eye worm) hypothetical protein 0.0084 0.0228 0.059
Echinococcus granulosus neuropeptide s receptor 0.0971 0.3322 0.3322
Schistosoma mansoni notch 0.0034 0.0054 0.0054
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.1175 0.4033 0.4033
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Giardia lamblia NADH oxidase lateral transfer candidate 0.0071 0.0181 0.3083
Schistosoma mansoni inositol monophosphatase 0.0151 0.0461 0.0461
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0071 0.0181 0.2753
Brugia malayi Hemopexin family protein 0.0458 0.1532 0.3969
Schistosoma mansoni notch 0.0034 0.0054 0.0054
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0102
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0019 0.0287
Schistosoma mansoni transcription factor btf3 0.0034 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Plasmodium vivax hypothetical protein, conserved 0.0022 0.0011 0.0106
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0153 0.2331
Toxoplasma gondii NAC domain-containing protein 0.0034 0.0053 0.0726
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0042 0.0081 0.1255
Echinococcus granulosus protein jagged 2 0.0034 0.0054 0.0054
Entamoeba histolytica aminopeptidase, putative 0.0042 0.0081 0.1543
Echinococcus granulosus sodium and chloride dependent glycine 0.0191 0.0601 0.0601
Onchocerca volvulus 0.0266 0.0862 0.2196
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Echinococcus multilocularis GPCR, family 2 0.0067 0.0168 0.0168
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0019 0.0287
Echinococcus multilocularis serotonin transporter 0.1126 0.3861 0.3861
Brugia malayi Latrophilin receptor protein 2 0.0067 0.0168 0.0436
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0069 0.0176 0.0176
Echinococcus multilocularis endothelin converting enzyme 1 0.0114 0.0332 0.0332
Onchocerca volvulus 0.0056 0.0131 0.0294
Loa Loa (eye worm) hypothetical protein 0.0323 0.1061 0.2749
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0134 0.2035
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Leishmania major hypothetical protein, conserved 0.0063 0.0155 0.2396
Schistosoma mansoni notch 0.0034 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0114 0.0332 0.0859
Echinococcus granulosus intestinal type alkaline phosphatase 0.0168 0.0521 0.0521
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0149 0.0452 0.0452
Giardia lamblia High cysteine protein 0.0034 0.0054 0.0922
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0249 0.0801 0.0801
Entamoeba histolytica hypothetical protein 0.0024 0.0018 0.0347
Loa Loa (eye worm) hypothetical protein 0.0086 0.0235 0.0608
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0071 0.0181 0.2798
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0042 0.0081 0.1255
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Schistosoma mansoni neprilysin-2 (M13 family) 0.0058 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0323 0.1061 0.2749
Loa Loa (eye worm) notch protein 0.0034 0.0054 0.014
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0069 0.0175 0.0175
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0042 0.0081 0.034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0028
Toxoplasma gondii hypothetical protein 0.0022 0.0011 0.0066
Onchocerca volvulus 0.0034 0.0054 0.0093
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0134 0.2084
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0052 0.0115 0.0298
Plasmodium vivax amine transporter, putative 0.0191 0.0601 0.9305
Plasmodium falciparum thioredoxin reductase 0.0204 0.0645 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0084 0.0225 0.0225
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0185 0.0185
Mycobacterium tuberculosis Probable dehydrogenase 0.0465 0.1556 0.8958
Echinococcus granulosus mothers against decapentaplegic 5 0.0069 0.0176 0.0176
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0034 0.0052 0.0052
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0042 0.0081 0.0081
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.1556
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Loa Loa (eye worm) hypothetical protein 0.0168 0.0521 0.135
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Entamoeba histolytica hypothetical protein 0.015 0.0458 0.8719
Mycobacterium ulcerans aminopeptidase N PepN 0.0042 0.0081 0.062
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0014 0.0059
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0228 0.059
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0071 0.0181 0.1039
Echinococcus granulosus thioredoxin glutathione reductase 0.0204 0.0645 0.0645
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0071 0.0181 0.2753
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.009 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0069 0.0175 0.0734
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0061 0.0147 0.2278
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0249 0.0801 0.0801
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0617 0.0617
Echinococcus granulosus phd:f box containing protein 0.0077 0.0202 0.0202
Echinococcus multilocularis neuropeptide s receptor 0.0971 0.3322 0.3322
Echinococcus granulosus lysine specific demethylase 5A 0.0298 0.0973 0.0973
Brugia malayi Animal haem peroxidase family protein 0.0266 0.0862 0.2233
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0402 0.1335 0.1335
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0 0.0001
Echinococcus granulosus JmjC domain containing protein 4 0.0077 0.0202 0.0202
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0191 0.0601 0.0601
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Trypanosoma cruzi trypanothione reductase, putative 0.0204 0.0645 1
Loa Loa (eye worm) CHromoDomain protein family member 0.0034 0.0052 0.0134
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0151 0.0461 0.7149
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0089 0.0245 0.3728
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0084 0.0225 0.0225
Schistosoma mansoni Smad4 0.0031 0.0042 0.0042
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0187 0.0585 0.0585
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.009 0.009
Brugia malayi MH1 domain containing protein 0.0069 0.0176 0.0456
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0042 0.0081 0.1255
Plasmodium falciparum heterochromatin protein 1 0.0024 0.0018 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0019 0.0078
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0033 0.0505
Loa Loa (eye worm) animal heme peroxidase 0.0266 0.0862 0.2233
Schistosoma mansoni methyl-cpg binding protein mbd 0.007 0.018 0.018
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.0647 0.1635
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0042 0.0177
Schistosoma mansoni hypothetical protein 0.2687 0.9306 0.9306
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0018 0.0077
Loa Loa (eye worm) Notch2 0.0034 0.0054 0.014
Onchocerca volvulus Peroxidase homolog 0.0266 0.0862 0.2196
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0077 0.0202 0.3134
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0054 0.014
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0028 0.0072
Onchocerca volvulus 0.003 0.004 0.0057
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0042 0.0081 0.034
Echinococcus multilocularis mothers against decapentaplegic 2 0.0031 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0024 0.0018 0.0018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0071 0.0181 0.0468
Brugia malayi Pre-SET motif family protein 0.0089 0.0245 0.0634
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0402 0.1335 0.3458
Toxoplasma gondii PHD-finger domain-containing protein 0.0187 0.0585 0.9064
Plasmodium vivax hypothetical protein, conserved 0.0187 0.0585 0.9068
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0071 0.0181 0.1408
Onchocerca volvulus 0.0458 0.1532 0.394
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.009 0.009
Onchocerca volvulus 0.0702 0.2383 0.6153
Onchocerca volvulus 0.0191 0.0601 0.1516
Brugia malayi RNA binding protein 0.0196 0.0617 0.1598
Loa Loa (eye worm) hypothetical protein 0.0883 0.3012 0.78
Schistosoma mansoni sodium/chloride dependent transporter 0.1126 0.3861 0.3861
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0054 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0134 0.0564
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0192 0.0604 0.3478
Loa Loa (eye worm) hypothetical protein 0.0212 0.0675 0.1748
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Onchocerca volvulus 0.0034 0.0054 0.0093
Brugia malayi mbt repeat family protein 0.0402 0.1335 0.3458
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.003 0.004 0.0169
Loa Loa (eye worm) hypothetical protein 0.0071 0.0181 0.0468
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0604 0.0604
Schistosoma mansoni myelin transcription factor 1 myt1 0.0457 0.1529 0.1529
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0071 0.0181 0.2798
Plasmodium vivax heterochromatin protein 1, putative 0.0024 0.0018 0.0223
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0069 0.0175 0.0175
Brugia malayi Delta serrate ligand family protein 0.0034 0.0054 0.014
Schistosoma mansoni aldehyde dehydrogenase 0.0192 0.0604 0.0604
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0095 0.0265 0.0265
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0617 0.0617
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0465 0.1556 0.8958
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0018 0.0077
Echinococcus multilocularis Smad4 0.0069 0.0176 0.0176
Schistosoma mansoni hypothetical protein 0.2454 0.8492 0.8492
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0151 0.0461 0.712
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0084 0.0225 0.3491
Entamoeba histolytica hypothetical protein 0.0023 0.0014 0.0266
Echinococcus multilocularis chromobox protein 1 0.0147 0.0448 0.0448
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.009 0.009
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0071 0.0181 0.0181
Loa Loa (eye worm) MH1 domain-containing protein 0.0069 0.0176 0.0456
Schistosoma mansoni hypothetical protein 0.015 0.0458 0.0458
Echinococcus granulosus neurogenic locus notch protein 0.0034 0.0054 0.0054
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0114 0.0332 0.0332
Echinococcus multilocularis alkaline phosphatase 0.0168 0.0521 0.0521
Echinococcus multilocularis Chromo domain 0.0024 0.0018 0.0018
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0028 0.0072
Entamoeba histolytica hypothetical protein 0.015 0.0458 0.8719
Onchocerca volvulus 0.1126 0.3861 1
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0038
Plasmodium vivax hypothetical protein, conserved 0.0191 0.0601 0.9305
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0042 0.0081 0.0081
Brugia malayi hypothetical protein 0.0024 0.0018 0.0047
Echinococcus multilocularis PHD finger protein rhinoceros 0.0187 0.0585 0.0585
Schistosoma mansoni smad 0.0069 0.0176 0.0176
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.018 0.2721
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0151 0.0461 0.1936
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0011 0.0082
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.017 0.017
Toxoplasma gondii EGF family domain-containing protein 0.0034 0.0054 0.0742
Loa Loa (eye worm) hypothetical protein 0.0086 0.0235 0.0608
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0077 0.0202 0.0202
Brugia malayi Peroxidasin 0.0266 0.0862 0.2233
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.1556
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0402 0.1335 0.3427
Echinococcus granulosus PHD finger protein rhinoceros 0.0187 0.0585 0.0585
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0071 0.0181 0.1381
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0031 0.0031
Loa Loa (eye worm) serotonin transporter b 0.1126 0.3861 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Entamoeba histolytica hypothetical protein 0.0024 0.0018 0.0347
Loa Loa (eye worm) animal heme peroxidase 0.0266 0.0862 0.2233
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0151 0.0461 0.7149
Brugia malayi N-terminal motif family protein 0.0204 0.0647 0.1674
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0135 0.0135
Schistosoma mansoni hypothetical protein 0.0085 0.0232 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0617 0.0617
Treponema pallidum NADH oxidase 0.0071 0.0181 0.0124
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0042 0.0081 0.1255
Echinococcus granulosus chromobox protein 1 0.0147 0.0448 0.0448
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0071 0.0181 0.2798
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0052 0.0115 0.0298
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0465 0.1556 0.8958
Loa Loa (eye worm) hypothetical protein 0.0067 0.0168 0.0436
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0168 0.0521 0.0521
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0134 0.0348
Echinococcus multilocularis peregrin 0.0197 0.062 0.062
Mycobacterium leprae probable zinc metalloprotease 0.0114 0.0332 0.1859
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0027 0.0029 0.0455
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0151 0.0461 0.1936
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0191 0.0601 0.0601
Loa Loa (eye worm) RNA binding protein 0.0196 0.0617 0.1598
Brugia malayi hypothetical protein 0.0266 0.0862 0.2233
Schistosoma mansoni chromobox protein 0.0024 0.0018 0.0018
Toxoplasma gondii aldehyde dehydrogenase 0.0192 0.0604 0.9358
Leishmania major importin beta-1 subunit, putative 0.0023 0.0014 0.0216
Onchocerca volvulus Peroxidasin homolog 0.0266 0.0862 0.2196
Echinococcus multilocularis neurogenic locus notch protein 0.0034 0.0054 0.0054
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0181 0.2798
Loa Loa (eye worm) norepinephrine transporter 0.1126 0.3861 1
Onchocerca volvulus 0.0266 0.0862 0.2196
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.009 0.009
Echinococcus multilocularis fat cadherin tumor suppressor 0.0034 0.0054 0.0054
Loa Loa (eye worm) zinc metallopeptidase 4 0.0028 0.0031 0.008
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0022 0.0011 0.0082
Schistosoma mansoni hypothetical protein 0.0067 0.0168 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.0329 0.0329
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0084 0.0225 0.3491
Echinococcus multilocularis sodium and chloride dependent glycine 0.0191 0.0601 0.0601
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0175 0.271
Schistosoma mansoni endothelin-converting enzyme-related 0.0028 0.0031 0.0031
Plasmodium vivax hypothetical protein, conserved 0.0024 0.0018 0.0223
Loa Loa (eye worm) hypothetical protein 0.0169 0.0525 0.136
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0007 0.0103
Loa Loa (eye worm) hypothetical protein 0.0114 0.0332 0.0859
Brugia malayi Thioredoxin reductase 0.0204 0.0645 0.1671
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0134 0.2084
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Onchocerca volvulus 0.0317 0.1041 0.2662
Echinococcus multilocularis polycomb protein SCMH1 0.0402 0.1335 0.1335
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0168 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Echinococcus granulosus peregrin 0.0197 0.062 0.062
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0212 0.0675 0.1748
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0604 0.4623
Echinococcus granulosus cpg binding protein 0.004 0.0074 0.0074
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.0053 0.082
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0004 0.003
Onchocerca volvulus Matrilysin homolog 0.0717 0.2434 0.6287
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0604 0.4623
Echinococcus multilocularis Chromobox protein 3 0.0024 0.0018 0.0018
Onchocerca volvulus 0.0143 0.0433 0.108
Onchocerca volvulus 0.0323 0.1061 0.2714
Entamoeba histolytica hypothetical protein 0.0024 0.0018 0.0347
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0063 0.0153 0.2331
Entamoeba histolytica hypothetical protein 0.0034 0.0053 0.1008
Mycobacterium ulcerans hypothetical protein 0.0027 0.0028 0.0211
Mycobacterium tuberculosis Probable zinc metalloprotease Zmp1 0.0114 0.0332 0.1909
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0028 0.0211
Trypanosoma brucei Aminopeptidase M1, putative 0.0042 0.0081 0.1255
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Brugia malayi PHD-finger family protein 0.0187 0.0585 0.1516
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0134 0.0348
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.003 0.0038 0.0038
Echinococcus multilocularis jumonji domain containing 1A 0.0077 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.1126 0.3861 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0228 0.059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.016 0.0491 0.0491
Schistosoma mansoni neprilysin 0.003 0.0038 0.0038
Loa Loa (eye worm) matrixin family protein 0.0782 0.266 0.6888
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0053 0.0222
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Echinococcus multilocularis isocitrate dehydrogenase 0.0084 0.0225 0.0225
Loa Loa (eye worm) inositol-1 0.0151 0.0461 0.1195
Brugia malayi hypothetical protein 0.0191 0.0601 0.1556
Brugia malayi SET domain containing protein 0.0028 0.0032 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0028 0.0159
Brugia malayi MH1 domain containing protein 0.0038 0.0068 0.0176
Mycobacterium ulcerans aldehyde dehydrogenase 0.0192 0.0604 0.4623
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0033 0.0033
Brugia malayi M-phase phosphoprotein, mpp8 0.0024 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.0128 0.0382 0.0988
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0061 0.0147 0.2278
Brugia malayi jmjC domain containing protein 0.0077 0.0202 0.0524
Echinococcus granulosus Chromo domain 0.0024 0.0018 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.009 0.009
Loa Loa (eye worm) hypothetical protein 0.1126 0.3861 1
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Schistosoma mansoni hypothetical protein 0.0024 0.0018 0.0018
Schistosoma mansoni smad1 5 8 and 0.0069 0.0176 0.0176
Brugia malayi jmjC domain containing protein 0.0674 0.2285 0.5917
Schistosoma mansoni sodium-dependent amino acid transporter 0.0191 0.0601 0.0601
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.004
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0024 0.0018 0.0047
Leishmania major basic transcription factor 3a, putative 0.0034 0.0053 0.082
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0028 0.0098
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0192 0.0604 0.9364
Brugia malayi Bromodomain containing protein 0.0197 0.062 0.1605
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0018 0.0183
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.9302
Echinococcus granulosus GPCR family 2 0.0067 0.0168 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.016 0.0491 0.0491
Schistosoma mansoni Smad4 0.0031 0.0042 0.0042
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0087 0.0236 0.0236
Trypanosoma cruzi trypanothione reductase, putative 0.0071 0.0181 0.2798
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0061 0.0147 0.2198
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0028 0.0526
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0024 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0178 0.0555 0.1437
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Plasmodium falciparum amino acid transporter, putative 0.0191 0.0601 0.9305
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0053 0.0222
Brugia malayi PHD-finger family protein 0.0071 0.0181 0.0468
Echinococcus granulosus chromobox protein 1 0.0147 0.0448 0.0448
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.003 0.004 0.0105
Schistosoma mansoni hypothetical protein 0.0063 0.0155 0.0155
Trypanosoma cruzi ISWI complex protein 0.0063 0.0155 0.2396
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0031 0.0042 0.0177
Schistosoma mansoni Smad4 0.0069 0.0176 0.0176
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0465 0.1556 0.8958
Brugia malayi PHD-finger family protein 0.0105 0.0299 0.0775
Brugia malayi Animal haem peroxidase family protein 0.0266 0.0862 0.2233
Loa Loa (eye worm) hypothetical protein 0.0084 0.0228 0.059
Toxoplasma gondii PHD-finger domain-containing protein 0.0187 0.0585 0.9064
Brugia malayi peptidase family M13 containing protein 0.0028 0.0031 0.008
Echinococcus multilocularis chromobox protein 2 0.0024 0.0018 0.0018
Brugia malayi Matrixin family protein 0.0323 0.1061 0.2749
Giardia lamblia PHD finger protein 15 0.0187 0.0585 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0457 0.1529 0.396
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Schistosoma mansoni ran 0.0021 0.0007 0.0007
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0134 0.2084
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0042 0.0177
Echinococcus granulosus snurportin 1 0.0302 0.0986 0.0986
Toxoplasma gondii hypothetical protein 0.0022 0.0011 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0031 0.0131
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0022 0.0011 0.0062
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Schistosoma mansoni sodium/chloride dependent transporter 0.0191 0.0601 0.0601
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.009 0.009
Echinococcus multilocularis phd:f box containing protein 0.0077 0.0202 0.0202
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0149 0.0452 0.0452
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0323 0.1061 0.1061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0072
Loa Loa (eye worm) TAR-binding protein 0.0196 0.0617 0.1598
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0028 0.0211
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Echinococcus granulosus transcription factor btf3 0.0034 0.0053 0.0053
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0134 0.2297
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0017
Schistosoma mansoni Nep2 peptidase (M13 family) 0.0058 0.0135 0.0135
Echinococcus granulosus neurogenic locus notch protein 4 0.0034 0.0054 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Brugia malayi Protein cec-1. 0.0024 0.0018 0.0047
Brugia malayi Calcitonin receptor-like protein seb-1 0.0212 0.0675 0.1748
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0024 0.0018 0.0183
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0018 0.0347
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0028 0.0031 0.0131
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0674 0.2285 0.2285
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0071 0.0181 0.1381
Onchocerca volvulus Slit protein homolog 0.0034 0.0054 0.0093
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0038
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0191 0.0601 0.0601
Schistosoma mansoni smad1 5 8 and 0.0069 0.0176 0.0176
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0517 0.1737 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.1556
Loa Loa (eye worm) matrixin family protein 0.0717 0.2434 0.6304
Echinococcus granulosus fibropellin Ia 0.0034 0.0054 0.0054
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0053 0.0222
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.015 0.0458 0.0458
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0222 0.0531
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0047 0.0098 0.1521
Loa Loa (eye worm) PHD-finger family protein 0.0187 0.0585 0.1516
Brugia malayi RNA recognition motif domain containing protein 0.0196 0.0617 0.1598
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0134 0.0564
Schistosoma mansoni cpg binding protein 0.003 0.004 0.004
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.9302
Echinococcus multilocularis JmjC domain containing protein 4 0.0077 0.0202 0.0202
Loa Loa (eye worm) bromodomain containing protein 0.0073 0.0189 0.0489
Schistosoma mansoni hypothetical protein 0.2687 0.9306 0.9306
Schistosoma mansoni chromobox protein 0.0147 0.0448 0.0448
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.0083 0.0222 0.0576
Brugia malayi Animal haem peroxidase family protein 0.0266 0.0862 0.2233
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0053 0.082
Schistosoma mansoni sex comb on midleg homolog 0.0402 0.1335 0.1335
Brugia malayi AF-10 protein 0.0061 0.0147 0.0381
Echinococcus granulosus importin subunit beta 1 0.0028 0.0033 0.0033
Brugia malayi MH2 domain containing protein 0.0031 0.0042 0.0109
Trichomonas vaginalis ran, putative 0.0021 0.0007 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0 0.0001
Echinococcus granulosus aminopeptidase N 0.0143 0.0433 0.0433
Brugia malayi Peptidase family M1 containing protein 0.0042 0.0081 0.021
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0014 0.0059
Echinococcus granulosus neural cadherin 0.0034 0.0054 0.0054
Echinococcus multilocularis Protein lozenge 0.0111 0.032 0.032
Echinococcus granulosus tar DNA binding protein 0.0196 0.0617 0.0617
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.1595 0.5496 0.5496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.009 0.009
Schistosoma mansoni hypothetical protein 0.0087 0.0239 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Onchocerca volvulus 0.0027 0.0028 0.0024
Loa Loa (eye worm) hypothetical protein 0.0077 0.0202 0.0524
Onchocerca volvulus Peroxidase homolog 0.0266 0.0862 0.2196
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0071 0.0181 0.2723
Brugia malayi Hypothetical zinc metalloproteinase T16A9.4 0.0114 0.0332 0.0859
Loa Loa (eye worm) mbt repeat family protein 0.0402 0.1335 0.3458
Loa Loa (eye worm) helicase 0.0024 0.0018 0.0047
Mycobacterium ulcerans hydrolase 0.0394 0.1307 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0024 0.0018 0.0183
Echinococcus granulosus neuropeptide receptor A26 0.0971 0.3322 0.3322
Brugia malayi beta-NAC-like protein 0.0034 0.0053 0.0137
Brugia malayi hypothetical protein 0.0883 0.3012 0.78
Echinococcus multilocularis fibropellin Ia 0.0034 0.0054 0.0054
Brugia malayi EGF-like domain containing protein 0.0034 0.0054 0.014
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0145 0.061
Brugia malayi MH2 domain containing protein 0.0069 0.0176 0.0456
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0007 0.004
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0134 0.0774
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0089 0.0245 0.0245
Schistosoma mansoni hypothetical protein 0.0145 0.044 0.044
Echinococcus multilocularis thioredoxin glutathione reductase 0.0204 0.0645 0.0645
Echinococcus granulosus fetal alzheimer antigen falz 0.0095 0.0265 0.0265
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Loa Loa (eye worm) jmjC domain-containing protein 0.0298 0.0973 0.252
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Schistosoma mansoni transcription factor LCR-F1 0.015 0.0458 0.0458
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0181 0.2798
Echinococcus granulosus TGF beta signal transducer SmadC 0.0069 0.0176 0.0176
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0018 0.0077
Loa Loa (eye worm) hypothetical protein 0.0086 0.0235 0.0608
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0071 0.0181 0.1381
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Trichomonas vaginalis conserved hypothetical protein 0.0061 0.0145 0.061
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Loa Loa (eye worm) hypothetical protein 0.0065 0.016 0.0415
Brugia malayi Associated with TFs and helicases family protein 0.0024 0.0018 0.0047
Onchocerca volvulus 0.0113 0.0329 0.0808
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.0053 0.082
Onchocerca volvulus Dual oxidase homolog 0.0266 0.0862 0.2196
Echinococcus granulosus histone acetyltransferase MYST2 0.0457 0.1529 0.1529
Plasmodium falciparum JmjC domain-containing protein, putative 0.0077 0.0202 0.3091
Schistosoma mansoni jumonji/arid domain-containing protein 0.0298 0.0973 0.0973
Echinococcus granulosus endothelin converting enzyme 1 0.0114 0.0332 0.0332
Onchocerca volvulus 0.0065 0.016 0.0369
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0028 0.0211
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Trichomonas vaginalis chromobox protein, putative 0.0147 0.0448 0.1882
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0394 0.1307 0.3385
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Brugia malayi Importin beta-1 subunit 0.0028 0.0033 0.0084
Schistosoma mansoni sex comb on midleg homolog 0.0402 0.1335 0.1335
Echinococcus granulosus jumonji domain containing protein 0.026 0.0841 0.0841
Echinococcus granulosus neurogenic locus protein delta 0.0034 0.0054 0.0054
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0071 0.0181 0.2753
Echinococcus multilocularis histone acetyltransferase MYST2 0.0457 0.1529 0.1529
Entamoeba histolytica Ran family GTPase 0.0021 0.0007 0.0125
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Echinococcus multilocularis zinc finger protein 0.0083 0.0222 0.0222
Brugia malayi Bromodomain containing protein 0.0158 0.0486 0.1259
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0151 0.0461 0.7149
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0204 0.0645 0.3714
Loa Loa (eye worm) hypothetical protein 0.0394 0.1307 0.3385
Loa Loa (eye worm) hypothetical protein 0.0114 0.0332 0.0859
Echinococcus granulosus protein jagged 1 0.0034 0.0054 0.0054
Toxoplasma gondii hypothetical protein 0.0191 0.0601 0.9302
Brugia malayi chromobox protein homolog 3 0.0083 0.0222 0.0576
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0084 0.0225 0.1297
Loa Loa (eye worm) hypothetical protein 0.0292 0.0954 0.247
Brugia malayi Isocitrate dehydrogenase 0.0084 0.0225 0.0583
Loa Loa (eye worm) PHD-finger family protein 0.0085 0.0232 0.06
Schistosoma mansoni lozenge 0.0111 0.032 0.032
Brugia malayi Pre-SET motif family protein 0.0617 0.2086 0.5402
Loa Loa (eye worm) matrix metalloproteinase 0.0323 0.1061 0.2749
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0028 0.0211
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0047 0.0098 0.0412
Toxoplasma gondii thioredoxin reductase 0.0204 0.0645 1
Brugia malayi Smad1 0.0069 0.0176 0.0456
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0028 0.0211
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Loa Loa (eye worm) MH2 domain-containing protein 0.0031 0.0042 0.0109
Brugia malayi Cadherin domain containing protein 0.0034 0.0054 0.014
Echinococcus granulosus protein jagged 2 0.0034 0.0054 0.0054
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0071 0.0181 0.2753
Loa Loa (eye worm) hypothetical protein 0.0086 0.0235 0.0608
Brugia malayi notch-like transmembrane receptor 0.0034 0.0054 0.014
Brugia malayi hypothetical protein 0.0317 0.1041 0.2696
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0018 0.0077
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.1126 0.3861 0.3861
Onchocerca volvulus 0.0402 0.1335 0.3427
Brugia malayi Matrixin family protein 0.0323 0.1061 0.2749
Brugia malayi jmjC domain containing protein 0.0077 0.0202 0.0524
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0033 0.0505
Brugia malayi Calcium binding EGF domain containing protein 0.0034 0.0054 0.014
Brugia malayi mbt repeat family protein 0.0402 0.1335 0.3458
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0069 0.0175 0.0175
Echinococcus granulosus protein jagged 1 0.0034 0.0054 0.0054
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0019 0.0187
Brugia malayi Heterochromatin protein 1 0.0147 0.0448 0.1161
Echinococcus multilocularis cpg binding protein 0.004 0.0074 0.0074
Schistosoma mansoni smad 0.0031 0.0042 0.0042
Onchocerca volvulus 0.0266 0.0862 0.2196
Loa Loa (eye worm) glutathione reductase 0.0204 0.0645 0.1671
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0067 0.0168 0.0168
Onchocerca volvulus 0.0191 0.0601 0.1516
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.1556
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0028 0.0526
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Schistosoma mansoni endothelin-converting enzyme-like 1 (damage-induced neuronal endopeptidase) 0.0028 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0187 0.0585 0.1516
Toxoplasma gondii isocitrate dehydrogenase 0.0084 0.0225 0.3424
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0014 0.0216
Loa Loa (eye worm) hypothetical protein 0.0031 0.0042 0.0109
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0028 0.0072
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0191 0.0601 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.1556
Plasmodium vivax thioredoxin reductase, putative 0.0204 0.0645 1
Brugia malayi MH2 domain containing protein 0.1018 0.3485 0.9025
Trichomonas vaginalis chromobox protein, putative 0.0147 0.0448 0.1882
Trichomonas vaginalis mercuric reductase, putative 0.0071 0.0181 0.0758
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0018 0.0077
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0095 0.0265 0.0265
Brugia malayi Matrixin family protein 0.0782 0.266 0.6888
Echinococcus multilocularis transcription factor btf3 0.0034 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Loa Loa (eye worm) animal heme peroxidase 0.0266 0.0862 0.2233
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Loa Loa (eye worm) hypothetical protein 0.0457 0.1529 0.396
Plasmodium vivax SET domain protein, putative 0.0089 0.0245 0.3754
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0202 0.0524
Loa Loa (eye worm) nuclear factor I 0.0038 0.0068 0.0176
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Brugia malayi Animal haem peroxidase family protein 0.0266 0.0862 0.2233
Plasmodium falciparum glutathione reductase 0.0204 0.0645 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0067 0.0168 0.0168
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0027 0.0029 0.0123
Schistosoma mansoni importin beta-1 0.0028 0.0033 0.0033
Onchocerca volvulus 0.0024 0.0018 0.000000033604
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Brugia malayi Blistered cuticle protein 3 0.0266 0.0862 0.2233
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0027 0.0029 0.0029
Brugia malayi MH1 domain containing protein 0.0069 0.0176 0.0456
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Brugia malayi Sodium:neurotransmitter symporter family protein 0.1126 0.3861 1
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Toxoplasma gondii PHD-finger domain-containing protein 0.0061 0.0147 0.2198
Onchocerca volvulus Peroxidasin homolog 0.0266 0.0862 0.2196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0298 0.0973 0.0973
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0151 0.0461 0.8786
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0191 0.0601 0.9302
Brugia malayi Cadherin domain containing protein 0.0034 0.0054 0.014
Echinococcus multilocularis snurportin 1 0.0302 0.0986 0.0986
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0168 0.0521 0.0521
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0028 0.0159
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0169 0.0525 1
Trichomonas vaginalis Heterochromatin protein, putative 0.0024 0.0018 0.0077
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.0053 0.0763
Echinococcus multilocularis aminopeptidase N 0.0143 0.0433 0.0433
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0617 0.0617
Echinococcus multilocularis neurogenic locus protein delta 0.0034 0.0054 0.0054
Echinococcus granulosus peroxidasin 0.0266 0.0862 0.0862
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0077 0.0202 0.3063
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Onchocerca volvulus 0.0034 0.0054 0.0093
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0457 0.1529 0.1529
Schistosoma mansoni smad1 5 8 and 0.0069 0.0176 0.0176
Loa Loa (eye worm) MH1 domain-containing protein 0.0031 0.0042 0.0109
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0071 0.0181 0.2798
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0067 0.0168 0.0436
Loa Loa (eye worm) hypothetical protein 0.0019 0.0002 0.0005
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0134 0.1029
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0191 0.0601 0.0601
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.004 0.0104
Plasmodium vivax importin-beta 2, putative 0.0028 0.0033 0.0446
Brugia malayi Muscle positioning protein 4 0.0034 0.0054 0.014
Schistosoma mansoni bromodomain containing protein 0.0019 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0191 0.0601 0.1556
Loa Loa (eye worm) jmjC domain-containing protein 0.0077 0.0202 0.0524
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0014 0.0059
Onchocerca volvulus 0.0034 0.0054 0.0093
Schistosoma mansoni hypothetical protein 0.0458 0.1532 0.1532
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0089 0.0245 0.0245
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0077 0.0202 0.3063
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0069 0.0175 0.0734
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0077 0.0202 0.3134
Loa Loa (eye worm) hypothetical protein 0.0086 0.0235 0.0608
Loa Loa (eye worm) hypothetical protein 0.0027 0.0028 0.0072
Trypanosoma brucei trypanothione reductase 0.0204 0.0645 1
Echinococcus multilocularis lysine specific demethylase 6a 0.0077 0.0202 0.0202
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0465 0.1556 0.8958
Brugia malayi mothers against decapentaplegic homolog 3 0.0031 0.0042 0.0109
Loa Loa (eye worm) hypothetical protein 0.0077 0.0202 0.0524
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0191 0.0601 0.0601
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0022 0.0011 0.0062
Trypanosoma brucei ISWI complex protein 0.0063 0.0155 0.2396
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0102
Schistosoma mansoni tar DNA-binding protein 0.0196 0.0617 0.0617
Schistosoma mansoni phd/f-box containing protein 0.0077 0.0202 0.0202
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0191 0.0601 0.0601
Trichomonas vaginalis chromobox protein, putative 0.0024 0.0018 0.0077
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0034 0.0054 0.0093
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Loa Loa (eye worm) hypothetical protein 0.003 0.004 0.0105
Trichomonas vaginalis chromobox protein, putative 0.0089 0.0244 0.1025
Schistosoma mansoni zinc finger protein 0.0063 0.0155 0.0155
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0768 0.2611 0.2611
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.003 0.004 0.0105
Mycobacterium ulcerans putative regulatory protein 0.0022 0.0011 0.0082
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0028 0.0211
Schistosoma mansoni alkaline phosphatase 0.0168 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0071 0.0181 0.2958
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0038
Schistosoma mansoni family M13 non-peptidase homologue (M13 family) 0.0028 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.002 0.0004 0.001
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0191 0.0601 0.1556
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0151 0.0461 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0674 0.2285 0.2285
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.009 0.0232
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0071 0.0181 0.2798
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0084 0.0225 0.3491
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0077 0.0202 0.3134
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0034 0.0052 0.0052
Mycobacterium leprae PROBABLE HYDROLASE 0.0394 0.1307 0.7507
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0168 0.0521 0.0521
Schistosoma mansoni hypothetical protein 0.0067 0.0168 0.0168
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0191 0.0601 0.0601
Brugia malayi MH2 domain containing protein 0.0069 0.0176 0.0456
Brugia malayi jmjC domain containing protein 0.0077 0.0202 0.0524
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0169 0.0525 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0069 0.0175 0.0734
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0069 0.0175 0.271
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0007 0.0007
Echinococcus granulosus methyl CpG binding domain protein 2 0.007 0.018 0.018
Schistosoma mansoni hypothetical protein 0.003 0.0038 0.0038
Trypanosoma cruzi aminopeptidase, putative 0.0042 0.0081 0.1255
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0031 0.0042 0.0062
Echinococcus granulosus lysine specific demethylase 6a 0.0077 0.0202 0.0202
Brugia malayi glutathione reductase 0.0204 0.0645 0.1671
Mycobacterium ulcerans zinc metalloprotease 0.0114 0.0332 0.2538
Plasmodium falciparum GAF domain-related protein, putative 0.0022 0.0011 0.0106
Echinococcus granulosus notch 0.0034 0.0054 0.0054
Loa Loa (eye worm) peptidase family M13 containing protein 0.0084 0.0228 0.059
Echinococcus multilocularis peroxidasin 0.0266 0.0862 0.0862
Toxoplasma gondii isocitrate dehydrogenase 0.0084 0.0225 0.3424
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0192 0.0604 0.0604
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0 0.0001
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0031 0.0031
Brugia malayi MH1 domain containing protein 0.0038 0.0068 0.0176
Echinococcus granulosus smad 0.0069 0.0176 0.0176
Schistosoma mansoni chromobox protein 0.0024 0.0018 0.0018
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0058 0.0135 0.0135
Echinococcus multilocularis geminin 0.2687 0.9306 0.9306
Schistosoma mansoni hypothetical protein 0.0034 0.0054 0.0054
Echinococcus granulosus SAM and MBT domain containing protein 0.0402 0.1335 0.1335
Trichomonas vaginalis glutathione reductase, putative 0.0071 0.0181 0.0758
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1677 0.5783 0.5783
Onchocerca volvulus 0.0034 0.0054 0.0093
Schistosoma mansoni bromodomain containing protein 0.0263 0.0852 0.0852
Brugia malayi Peptidase family M13 containing protein 0.0114 0.0332 0.0859
Brugia malayi Inositol-1 0.0151 0.0461 0.1195
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0084 0.0225 0.3451
Loa Loa (eye worm) hypothetical protein 0.0024 0.0018 0.0047
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Echinococcus multilocularis lysine specific demethylase 5A 0.0288 0.094 0.094
Plasmodium vivax JmjC domain containing protein 0.0077 0.0202 0.3091
Leishmania major GTP-binding protein, putative 0.0021 0.0007 0.0102
Trichomonas vaginalis set domain proteins, putative 0.0702 0.2383 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.003 0.004 0.004
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0018 0.0347
Loa Loa (eye worm) jmjC domain-containing protein 0.0386 0.1279 0.3313
Loa Loa (eye worm) hypothetical protein 0.0266 0.0862 0.2233
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Brugia malayi CHD4 protein 0.0034 0.0052 0.0134
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0084 0.0225 0.3491
Schistosoma mansoni ran 0.0021 0.0007 0.0007
Schistosoma mansoni microtubule-associated protein tau 0.2886 1 1
Leishmania major trypanothione reductase 0.0204 0.0645 1
Schistosoma mansoni phosphatidylserine receptor 0.0077 0.0202 0.0202
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0457 0.1529 0.1529
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0034 0.0052 0.0052
Plasmodium vivax glutathione reductase, putative 0.0204 0.0645 1
Brugia malayi RNA, U transporter 1 0.008 0.0214 0.0555
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0031 0.0042 0.0177
Brugia malayi Peptidase family M1 containing protein 0.0143 0.0433 0.1122
Plasmodium falciparum glutathione reductase 0.0071 0.0181 0.2753
Onchocerca volvulus Putative cubilin 0.0034 0.0054 0.0093
Echinococcus granulosus geminin 0.2687 0.9306 0.9306
Loa Loa (eye worm) heterochromatin protein 1 0.0147 0.0448 0.1161
Mycobacterium tuberculosis Probable oxidoreductase 0.0517 0.1737 1
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0019 0.0019
Schistosoma mansoni cpg binding protein 0.004 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0222 0.0933
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0011 0.0045
Loa Loa (eye worm) hypothetical protein 0.016 0.0491 0.127
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0084 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0204 0.0647 0.1674
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.0053 0.0763
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0071 0.0181 0.2798
Echinococcus multilocularis protein jagged 1 0.0034 0.0054 0.0054
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0135 0.0406 0.2289
Leishmania major hypothetical protein, conserved 0.0077 0.0202 0.3134
Brugia malayi latrophilin 2 splice variant baaae 0.0145 0.044 0.1141
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.003 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0042 0.0081 0.0081
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0134 0.0134
Schistosoma mansoni family M13 unassigned peptidase (M13 family) 0.0028 0.0031 0.0031
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.0053 0.1008
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0024 0.0018 0.0018
Loa Loa (eye worm) runx1 0.0111 0.032 0.0829
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0047 0.0098 0.0412
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.014
Toxoplasma gondii peptidase family M13 protein 0.0114 0.0332 0.5091
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0071 0.0181 0.0181
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0007 0.0102
Echinococcus granulosus histone lysine methyltransferase setb 0.016 0.0491 0.0491
Schistosoma mansoni notch 0.0034 0.0054 0.0054
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0004 0.0023
Echinococcus multilocularis methyl CpG binding domain protein 2 0.007 0.018 0.018
Schistosoma mansoni hypothetical protein 0.0061 0.0147 0.0147
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0112
Schistosoma mansoni zinc finger protein 0.0083 0.0222 0.0222
Schistosoma mansoni ap endonuclease 0.0057 0.0134 0.0134
Echinococcus granulosus zinc finger protein 0.0083 0.0222 0.0222
Echinococcus multilocularis neuropeptide receptor A26 0.0971 0.3322 0.3322
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0042 0.0081 0.0081
Schistosoma mansoni slit 0.0034 0.0054 0.0054
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0089 0.0244 0.0588
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0087 0.0236 0.0236
Schistosoma mansoni cell polarity protein 0.0034 0.0054 0.0054
Trypanosoma cruzi ISWI complex protein 0.0063 0.0155 0.2396
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0028 0.0428
Echinococcus granulosus endonuclease exonuclease phosphatase 0.1595 0.5496 0.5496
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0069 0.0176 0.0176
Onchocerca volvulus 0.0883 0.3012 0.779
Entamoeba histolytica hypothetical protein 0.0024 0.0019 0.0352
Schistosoma mansoni chromobox protein 0.0147 0.0448 0.0448
Schistosoma mansoni hypothetical protein 0.0302 0.0986 0.0986
Echinococcus granulosus alkaline phosphatase 0.0168 0.0521 0.0521
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0069 0.0175 0.271
Plasmodium falciparum transporter, putative 0.0191 0.0601 0.9305
Entamoeba histolytica hypothetical protein 0.015 0.0458 0.8719
Loa Loa (eye worm) hypothetical protein 0.0317 0.1041 0.2696
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0007 0.0017
Trichomonas vaginalis chromobox protein, putative 0.0089 0.0244 0.1025
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0019 0.0048
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0069 0.0175 0.0734
Brugia malayi Bromodomain containing protein 0.0312 0.1021 0.2645
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0191 0.0601 0.0601
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.1175 0.4033 0.4033
Echinococcus multilocularis jumonji domain containing protein 0.026 0.0841 0.0841

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 11.7 nM Inhibitory activity on aminopeptidase N (APN) using Ala-pNA as substrate. ChEMBL. 10753476
Ki (binding) = 158 nM Inhibitory activity on neutral endopeptidase (NEP) using DGNPA as substrate. ChEMBL. 10753476

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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