Detailed information for compound 1275010

Basic information

Technical information
  • TDR Targets ID: 1275010
  • Name: 2-[3-[(2-chloro-4-fluorophenyl)methyl]-2-oxoi midazolidin-1-yl]acetic acid
  • MW: 286.687 | Formula: C12H12ClFN2O3
  • H donors: 1 H acceptors: 3 LogP: 1.33 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CN1CCN(C1=O)Cc1ccc(cc1Cl)F
  • InChi: 1S/C12H12ClFN2O3/c13-10-5-9(14)2-1-8(10)6-15-3-4-16(12(15)19)7-11(17)18/h1-2,5H,3-4,6-7H2,(H,17,18)
  • InChiKey: ZOTKRPMYHQFGQP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[3-[(2-chloro-4-fluoro-phenyl)methyl]-2-oxo-imidazolidin-1-yl]acetic acid
  • 2-[3-[(2-chloro-4-fluorophenyl)methyl]-2-oxo-1-imidazolidinyl]acetic acid
  • 2-[3-(2-chloro-4-fluoro-benzyl)-2-keto-imidazolidin-1-yl]acetic acid
  • 2-[3-[(2-chloro-4-fluoro-phenyl)methyl]-2-oxo-imidazolidin-1-yl]ethanoic acid
  • MLS000095780
  • SMR000031328
  • [3-(2-chloro-4-fluorobenzyl)-2-oxoimidazolidin-1-yl]acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0026 0.0061
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0126 0.0464 0.7298
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0021 0.0024 0.0238
Giardia lamblia Sugar-proton symporter 0.008 0.0268 0.1698
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0914 0.3767 0.5677
Plasmodium falciparum protein kinase 7 0.1598 0.6635 0.6635
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0046 0.02
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Giardia lamblia Fructose-bisphosphate aldolase 0.033 0.1317 0.8341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Plasmodium falciparum plasmepsin III 0.0059 0.018 0.018
Plasmodium falciparum asparagine--tRNA ligase 0.0019 0.0015 0.0015
Giardia lamblia TCP-1 chaperonin subunit beta 0.0027 0.0048 0.0303
Echinococcus multilocularis musashi 0.0083 0.0282 0.0654
Echinococcus granulosus solute carrier family 22 0.008 0.0268 0.0623
Trichomonas vaginalis glutathione reductase, putative 0.0026 0.0042 0.0183
Echinococcus granulosus General substrate transporter 0.0486 0.1973 0.4581
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0514 0.1194
Loa Loa (eye worm) hypothetical protein 0.0083 0.0282 0.1222
Plasmodium vivax ataxin-2 like protein, putative 0.0053 0.0159 0.0159
Onchocerca volvulus 0.0041 0.0105 0.1829
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Plasmodium vivax histidine--tRNA ligase, putative 0.0019 0.0015 0.0015
Echinococcus granulosus solute carrier family 22 0.008 0.0268 0.0623
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.017 0.0646 0.2802
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Loa Loa (eye worm) CYP4Cod1 0.0032 0.0069 0.0298
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0066 0.01
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0085 0.1109
Wolbachia endosymbiont of Brugia malayi threonyl-tRNA synthetase 0.0032 0.0068 0.0871
Loa Loa (eye worm) hypothetical protein 0.0216 0.084 0.3643
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0026 0.0042 0.045
Plasmodium falciparum thioredoxin reductase 0.0055 0.0167 0.0167
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0173 0.0661 0.2866
Brugia malayi hypothetical protein 0.0059 0.018 0.0781
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0166 0.0631 0.2734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0047 0.0205
Toxoplasma gondii ABC1 family protein 0.0041 0.0105 0.0158
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0123 0.0534
Toxoplasma gondii aspartyl protease ASP1 0.0059 0.018 0.0272
Echinococcus multilocularis thioredoxin glutathione reductase 0.0056 0.017 0.0395
Leishmania major hypothetical protein, conserved 0.0053 0.0159 0.2076
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0173 0.0661 0.2866
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0198 0.0764 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.0138 0.0513 0.2224
Schistosoma mansoni hypothetical protein 0.0114 0.0411 0.068
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0198 0.0764 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0123 0.0534
Schistosoma mansoni hypothetical protein 0.0021 0.0024 0.004
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0126 0.0464 0.7182
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0105 0.1375
Loa Loa (eye worm) hypothetical protein 0.0169 0.0641 0.2781
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0021 0.0024 0.0159
Schistosoma mansoni hypothetical protein 0.0114 0.0411 0.068
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0021 0.0024 0.0238
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0053 0.0689
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0198 0.0764 1
Schistosoma mansoni cathepsin D (A01 family) 0.0059 0.018 0.0298
Mycobacterium tuberculosis Probable esterase LipL 0.0041 0.0105 0.1027
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0218 0.0944
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0914 0.3767 0.3767
Treponema pallidum threonyl-tRNA synthetase 0.0032 0.0068 0.0412
Treponema pallidum fructose-bisphosphate aldolase 0.033 0.1317 1
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0159 0.2076
Giardia lamblia Threonyl-tRNA synthetase 0.0032 0.0068 0.0432
Echinococcus granulosus solute carrier family 22 0.008 0.0268 0.0623
Leishmania major cytochrome p450-like protein 0.0021 0.0024 0.0319
Trypanosoma cruzi histidyl-tRNA synthetase 0.0019 0.0015 0.0195
Toxoplasma gondii t-complex protein beta subunit 0.0027 0.0048 0.0072
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0123 0.0204
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0066 0.01
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0107 0.0384 0.5947
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0026 0.0042 0.0553
Toxoplasma gondii aspartate-tRNA ligase 0.0019 0.0015 0.0022
Chlamydia trachomatis threonine--tRNA ligase 0.0032 0.0068 0.0871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0157
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Echinococcus granulosus short transient receptor potential channel 6 0.0143 0.0534 0.1239
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0066 0.0287
Entamoeba histolytica Rad52/22 family double-strand break repair protein, putative 0.0112 0.0403 0.255
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0059 0.018 0.0272
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0015 0.0034
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0061
Onchocerca volvulus 0.008 0.0268 0.4668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0091 0.1578
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Mycobacterium leprae Conserved hypothetical protein 0.0021 0.0024 0.0377
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Trichomonas vaginalis dihydrolipoamide dehydrogenase, putative 0.0166 0.0631 0.2734
Trichomonas vaginalis CAMK family protein kinase 0.0173 0.0661 0.2866
Plasmodium vivax proline--tRNA ligase, putative 0.0198 0.0764 0.0764
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Plasmodium vivax hexose transporter 0.0566 0.2306 0.2306
Trypanosoma brucei pyruvate kinase 1, putative 0.0037 0.0091 0.1187
Leishmania major glucose transporter, lmgt1 0.0175 0.067 0.8771
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Echinococcus multilocularis calcium activated potassium channel 0.0018 0.001 0.0024
Plasmodium vivax asparagine--tRNA ligase, putative 0.0019 0.0015 0.0015
Loa Loa (eye worm) 63kd antigen 0.0019 0.0015 0.0063
Loa Loa (eye worm) hypothetical protein 0.0494 0.2008 0.8706
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.017 0.0646 0.2802
Brugia malayi Eukaryotic aspartyl protease family protein 0.0059 0.018 0.0781
Schistosoma mansoni hypothetical protein 0.0114 0.0411 0.068
Plasmodium vivax plasmepsin IV, putative 0.0059 0.018 0.018
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0173 0.0661 0.0661
Schistosoma mansoni pyruvate kinase 0.0037 0.0091 0.015
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0021 0.0024 0.0238
Echinococcus granulosus transient receptor potential gamma protein 0.0216 0.084 0.1951
Schistosoma mansoni hypothetical protein 0.0511 0.2077 0.3437
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0059 0.018 0.0418
Onchocerca volvulus 0.008 0.0268 0.4668
Brugia malayi Cytochrome P450 family protein 0.0032 0.0069 0.0298
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0027 0.0048 0.0627
Trypanosoma brucei THT1 - hexose transporter, putative 0.0175 0.067 0.8771
Trypanosoma cruzi sugar transporter, putative 0.008 0.0268 0.351
Trypanosoma brucei glucose transporter 2A 0.0175 0.067 0.8771
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0416
Brugia malayi glycyl-tRNA synthetase 0.0032 0.0068 0.0296
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0026 0.0341
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0066 0.0866
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0026 0.0113
Leishmania major pyruvate kinase 0.0037 0.0091 0.1187
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0019 0.0015 0.0195
Echinococcus granulosus survival motor neuron protein 1 0.0494 0.2008 0.4663
Onchocerca volvulus 0.008 0.0268 0.4668
Onchocerca volvulus 0.0059 0.018 0.3135
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0123 0.0286
Plasmodium falciparum pyruvate kinase 2 0.0019 0.0015 0.0015
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0173 0.0661 0.0997
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0021 0.0024 0.0159
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0042 0.0553
Leishmania major T-complex protein 1, beta subunit, putative 0.0027 0.0048 0.0627
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.008 0.0268 0.4118
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0173 0.0661 0.0997
Plasmodium falciparum glutathione reductase 0.0026 0.0042 0.0042
Schistosoma mansoni protein kinase 0.0173 0.0661 0.1093
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0198 0.0764 1
Echinococcus granulosus solute carrier family 22 0.008 0.0268 0.0623
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0101 0.0358 0.1551
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0359 0.1439 0.624
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0514 0.085
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0114 0.0413 0.4036
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Trichomonas vaginalis glucose transporter, putative 0.008 0.0268 0.1163
Echinococcus granulosus Threonyl tRNA synthetase C 0.0032 0.0068 0.0158
Echinococcus multilocularis pyruvate kinase 0.0019 0.0015 0.0034
Schistosoma mansoni hypothetical protein 0.0566 0.2306 0.3815
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0158
Plasmodium vivax aspartyl protease, putative 0.0059 0.018 0.018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Giardia lamblia Thioredoxin reductase 0.0166 0.0631 0.3992
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Wolbachia endosymbiont of Brugia malayi thioredoxin reductase 0.0166 0.0631 1
Schistosoma mansoni lamin 0.0083 0.0282 0.0466
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0114 0.0411 0.0954
Leishmania major glucose transporter, lmgt3 0.0175 0.067 0.8771
Mycobacterium tuberculosis Probable hydrolase 0.0041 0.0105 0.1027
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0105 0.1375
Echinococcus multilocularis solute carrier family 22 0.008 0.0268 0.0623
Plasmodium falciparum glutathione reductase 0.0055 0.0167 0.0167
Schistosoma mansoni cellular tumor antigen P53 0.0153 0.0575 0.0951
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0032 0.0069 0.088
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Mycobacterium ulcerans hypothetical protein 0.0028 0.0053 0.0619
Brugia malayi Intermediate filament tail domain containing protein 0.0083 0.0282 0.1222
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0021 0.0024 0.0159
Giardia lamblia NADH oxidase lateral transfer candidate 0.0026 0.0042 0.0268
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0021 0.0024 0.0238
Mycobacterium tuberculosis Possible penicillin-binding protein 0.026 0.1023 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0114 0.0411 0.0954
Plasmodium vivax aspartyl protease, putative 0.0059 0.018 0.018
Onchocerca volvulus 0.0153 0.0575 1
Brugia malayi isocitrate dehydrogenase 0.0031 0.0066 0.0287
Leishmania major histidyl-tRNA synthetase, putative 0.0019 0.0015 0.0195
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0021 0.0024 0.0238
Loa Loa (eye worm) histidyl-tRNA synthetase 0.0019 0.0015 0.0065
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0066 0.0154
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0123 0.1611
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0026 0.0042 0.0098
Brugia malayi hypothetical protein 0.0034 0.0079 0.0344
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0341
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.018 0.018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0027 0.0048 0.0303
Onchocerca volvulus 0.0101 0.0358 0.6224
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0027 0.0048 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0114 0.0411 0.0954
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0026 0.0042 0.0183
Loa Loa (eye worm) cytochrome P450 0.0021 0.0024 0.0106
Trypanosoma brucei threonyl-tRNA synthetase, putative 0.0032 0.0068 0.0892
Leishmania major glycyl tRNA synthetase, putative 0.0019 0.0015 0.0195
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0105 0.0244
Leishmania major asparaginyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0268 0.1163
Leishmania major pyruvate kinase 0.0037 0.0091 0.1187
Echinococcus granulosus short transient receptor potential channel 6 0.0143 0.0534 0.1239
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0105 0.0456
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0026 0.0113
Onchocerca volvulus 0.008 0.0268 0.4668
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Plasmodium vivax plasmepsin V, putative 0.0059 0.018 0.018
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0021 0.0024 0.0159
Trichomonas vaginalis threonyl-tRNA synthetase, putative 0.0032 0.0068 0.0296
Echinococcus granulosus dna polymerase eta 0.0022 0.0026 0.0061
Entamoeba histolytica hypothetical protein 0.0072 0.0235 0.1487
Toxoplasma gondii LsmAD domain-containing protein 0.0053 0.0159 0.0239
Mycobacterium ulcerans pyruvate kinase 0.0037 0.0091 0.1236
Mycobacterium tuberculosis Conserved hypothetical protein 0.0028 0.0053 0.0515
Chlamydia trachomatis thioredoxin reductase 0.0166 0.0631 1
Leishmania major DNA polymerase eta, putative 0.0022 0.0026 0.0341
Leishmania major DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Brugia malayi glutathione reductase 0.0055 0.0167 0.0726
Onchocerca volvulus 0.008 0.0268 0.4668
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.008 0.0268 0.2622
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.0024 0.0319
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0123 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0167 0.0167
Mycobacterium tuberculosis Probable oxidoreductase 0.0126 0.0462 0.4513
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0021 0.0024 0.0159
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0123 0.1611
Brugia malayi Pyruvate kinase, muscle isozyme 0.0037 0.0091 0.0393
Brugia malayi beta-lactamase family protein 0.0041 0.0105 0.0456
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.043 0.1865
Plasmodium vivax lysine--tRNA ligase, putative 0.0126 0.0464 0.0464
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.067 0.2906
Schistosoma mansoni intermediate filament proteins 0.0083 0.0282 0.0466
Echinococcus granulosus lamin 0.0083 0.0282 0.0654
Echinococcus multilocularis transient receptor potential gamma protein 0.0216 0.084 0.1951
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Echinococcus multilocularis muscleblind protein 1 0.0169 0.0641 0.149
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0083 0.0282 0.1222
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0166 0.0631 0.2734
Plasmodium falciparum proline--tRNA ligase 0.0198 0.0764 0.0764
Echinococcus multilocularis geminin 0.0511 0.2077 0.4824
Toxoplasma gondii threonyl-tRNA synthetase family protein 0.0032 0.0068 0.0103
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0026 0.0042 0.0413
Plasmodium falciparum thioredoxin reductase 0.0026 0.0042 0.0042
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0021 0.0024 0.0159
Onchocerca volvulus 0.008 0.0268 0.4668
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0123 0.1611
Echinococcus granulosus muscleblind protein 0.0169 0.0641 0.149
Toxoplasma gondii pyruvate kinase PyK1 0.0037 0.0091 0.0137
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0021 0.0024 0.0159
Schistosoma mansoni glucose transport protein 0.0566 0.2306 0.3815
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0026 0.0113
Echinococcus multilocularis short transient receptor potential channel 6 0.0143 0.0534 0.1239
Brugia malayi beta-lactamase family protein 0.0041 0.0105 0.0456
Plasmodium falciparum plasmepsin II 0.0059 0.018 0.018
Echinococcus granulosus glycyl tRNA synthetase 0.0032 0.0068 0.0158
Loa Loa (eye worm) hypothetical protein 0.0169 0.0641 0.2781
Mycobacterium tuberculosis Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase)(ThrRS) (threonine-tRNA ligase) 0.0032 0.0068 0.0666
Echinococcus granulosus pyruvate kinase 0.0037 0.0091 0.0211
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0027 0.0048 0.0111
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0173 0.0661 0.0661
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0021 0.0024 0.0238
Plasmodium falciparum plasmepsin IX 0.0059 0.018 0.018
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.017 0.0646 1
Plasmodium falciparum aspartate--tRNA ligase 0.0019 0.0015 0.0015
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0026 0.0042 0.045
Plasmodium falciparum hexose transporter 0.0566 0.2306 0.2306
Chlamydia trachomatis histidine--tRNA ligase 0.0019 0.0015 0.0006
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.008 0.0268 0.351
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0114 0.0413 0.4036
Echinococcus multilocularis aspartyl tRNA synthetase, cytoplasmic 0.0019 0.0015 0.0034
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0021 0.0024 0.0159
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0027 0.0048 0.0111
Mycobacterium ulcerans lipase LipD 0.0041 0.0105 0.147
Echinococcus multilocularis TRP (transient receptor potential) channel 0.008 0.0272 0.063
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0024 0.0319
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0123 0.0779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0046 0.02
Giardia lamblia Glycyl-tRNA synthetase 0.0032 0.0068 0.0432
Loa Loa (eye worm) glycyl-tRNA synthetase 0.0032 0.0068 0.0296
Loa Loa (eye worm) sugar transporter 0.008 0.0268 0.1163
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0066 0.0154
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0042 0.045
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0026 0.0042 0.0553
Echinococcus multilocularis solute carrier family 22 0.008 0.0268 0.0623
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0161 0.061 0.5965
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0069 0.0298
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0105 0.1626
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0159 0.0159
Trypanosoma brucei glycyl-tRNA synthetase, putative 0.0032 0.0068 0.0892
Echinococcus multilocularis 0.0021 0.0024 0.0057
Loa Loa (eye worm) T-complex protein 1 0.0027 0.0048 0.0208
Plasmodium falciparum plasmepsin V 0.0059 0.018 0.018
Trichomonas vaginalis esterase, putative 0.0041 0.0105 0.0456
Onchocerca volvulus 0.0041 0.0105 0.1829
Entamoeba histolytica DNA repair and recombination protein RAD52, putative 0.0392 0.1579 1
Schistosoma mansoni hypothetical protein 0.0101 0.0358 0.0592
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0059 0.018 0.0418
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0057 0.0247
Plasmodium falciparum glycine--tRNA ligase 0.0019 0.0015 0.0015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.0514 0.1194
Toxoplasma gondii protein kinase, putative 0.1598 0.6635 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0026 0.0255
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0066 0.0066
Trichomonas vaginalis myo-inositol transporter, putative 0.008 0.0268 0.1163
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0021 0.0024 0.0159
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.017 0.0646 0.4091
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0268 0.1163
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0069 0.0899
Schistosoma mansoni hypothetical protein 0.0114 0.0411 0.068
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0075 0.0113
Trypanosoma brucei histidyl-tRNA synthetase 0.0019 0.0015 0.0195
Plasmodium falciparum plasmepsin I 0.0059 0.018 0.018
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0167 0.0726
Plasmodium vivax threonine--tRNA ligase, putative 0.0032 0.0068 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0085 0.0367
Loa Loa (eye worm) hypothetical protein 0.0038 0.0096 0.0416
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Brugia malayi Calcitonin receptor-like protein seb-1 0.0359 0.1439 0.624
Leishmania major glucose transporter/membrane transporter D2, putative 0.0175 0.067 0.8771
Echinococcus granulosus lysyl tRNA synthetase 0.0126 0.0464 0.1078
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0113
Schistosoma mansoni DNA polymerase eta 0.0022 0.0026 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0105 0.0456
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0026 0.0042 0.0042
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0085 0.0367
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0026 0.0042 0.0064
Toxoplasma gondii transporter, major facilitator family protein 0.008 0.0268 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0157
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0105 0.0456
Trypanosoma brucei sugar transporter, putative 0.008 0.0268 0.351
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0158
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0026 0.0341
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0173 0.0661 0.865
Echinococcus granulosus pyruvate kinase 0.0019 0.0015 0.0034
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trypanosoma brucei trypanothione reductase 0.0055 0.0167 0.2192
Echinococcus multilocularis General substrate transporter 0.0486 0.1973 0.4581
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0121 0.0523
Entamoeba histolytica asparaginyl-tRNA synthetase, putative 0.0019 0.0015 0.0092
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0026 0.0042 0.0042
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0048 0.0208
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0066 0.0866
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0126 0.0462 0.4513
Onchocerca volvulus 0.0083 0.0282 0.4904
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0066 0.0154
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Toxoplasma gondii facilitative glucose transporter GT1 0.0566 0.2306 0.3476
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0026 0.0042 0.045
Entamoeba histolytica protein kinase, putative 0.0173 0.0661 0.4185
Trichomonas vaginalis interferon-induced, double-stranded RNA-activated protein kinase, putative 0.0019 0.0015 0.0065
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Brugia malayi Thioredoxin reductase 0.0055 0.0167 0.0726
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0021 0.0024 0.0238
Mycobacterium tuberculosis Conserved protein 0.0041 0.0105 0.1027
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0091 0.1187
Schistosoma mansoni threonyl-tRNA synthetase 0.0019 0.0015 0.0025
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Brugia malayi probable proline-trna synthetase - fission yeast, putative 0.0032 0.0068 0.0296
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.008 0.0268 0.4118
Schistosoma mansoni hypothetical protein 0.0511 0.2077 0.3437
Echinococcus multilocularis lysyl tRNA synthetase 0.0126 0.0464 0.1078
Trypanosoma brucei unspecified product 0.0022 0.0026 0.0341
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.043 0.1865
Loa Loa (eye worm) hypothetical protein 0.0053 0.0159 0.0688
Echinococcus granulosus aspartyl tRNA synthetase cytoplasmic 0.0019 0.0015 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0114 0.0411 0.0954
Echinococcus multilocularis glycyl tRNA synthetase 0.0032 0.0068 0.0158
Toxoplasma gondii YbaK/proline-tRNA ligase associated domain-containing protein 0.0028 0.0053 0.0079
Toxoplasma gondii sugar transporter ST2 0.008 0.0268 0.0404
Loa Loa (eye worm) hypothetical protein 0.0245 0.0963 0.4176
Schistosoma mansoni histidyl-tRNA synthetase 0.0019 0.0015 0.0025
Leishmania major threonyl-tRNA synthetase, putative 0.0032 0.0068 0.0892
Loa Loa (eye worm) glutathione reductase 0.0055 0.0167 0.0726
Leishmania major aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Trypanosoma brucei THT1 - hexose transporter, putative 0.0175 0.067 0.8771
Giardia lamblia DINP protein human, muc B family 0.0022 0.0026 0.0165
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0085 0.0367
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0026 0.0043
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Brugia malayi latrophilin 2 splice variant baaae 0.0245 0.0963 0.4176
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0107 0.0384 0.3757
Brugia malayi Major Facilitator Superfamily protein 0.008 0.0268 0.1163
Loa Loa (eye worm) hypothetical protein 0.0073 0.0241 0.1046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0096 0.0414
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0021 0.0024 0.0159
Treponema pallidum thioredoxin reductase (trxB) 0.0166 0.0631 0.4728
Schistosoma mansoni glucose transporter 0.008 0.0268 0.0444
Onchocerca volvulus 0.008 0.0268 0.4668
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0456
Echinococcus granulosus asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0015 0.0034
Echinococcus multilocularis solute carrier family 22 0.008 0.0268 0.0623
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0047 0.0205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Mycobacterium leprae THIOREDOXIN TRXC (TRX) (MPT46) 0.0166 0.0631 0.9757
Plasmodium falciparum lysine--tRNA ligase 0.0126 0.0464 0.0464
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0026 0.0042 0.045
Entamoeba histolytica aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.0092
Schistosoma mansoni sugar transporter 0.008 0.0268 0.0444
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Onchocerca volvulus 0.008 0.0268 0.4668
Brugia malayi Cytochrome P450 family protein 0.0021 0.0024 0.0106
Trichomonas vaginalis glycyl-tRNA synthetase, putative 0.0019 0.0015 0.0065
Plasmodium vivax aspartyl protease, putative 0.0059 0.018 0.018
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Mycobacterium tuberculosis Conserved protein 0.0041 0.0105 0.1027
Echinococcus granulosus asparaginyl tRNA synthetase cytoplasmic 0.0019 0.0015 0.0034
Brugia malayi Latrophilin receptor protein 2 0.0114 0.0411 0.1781
Echinococcus granulosus tumor protein p63 0.1042 0.4306 1
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0028 0.0053 0.0689
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0021 0.0024 0.0159
Echinococcus multilocularis pyruvate kinase 0.0037 0.0091 0.0211
Schistosoma mansoni glucose transport protein 0.0566 0.2306 0.3815
Mycobacterium ulcerans histidyl-tRNA synthetase 0.0019 0.0015 0.0006
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Loa Loa (eye worm) hypothetical protein 0.0136 0.0503 0.2183
Trypanosoma brucei THT1 - hexose transporter, putative 0.0175 0.067 0.8771
Trypanosoma brucei glucose transporter 1E 0.0175 0.067 0.8771
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Entamoeba histolytica hypothetical protein 0.0112 0.0403 0.255
Echinococcus granulosus geminin 0.0511 0.2077 0.4824
Brugia malayi Aspartyl-tRNA synthetase 0.0019 0.0015 0.0063
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Loa Loa (eye worm) hypothetical protein 0.0026 0.0044 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0091 0.0393
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0123 0.0779
Echinococcus multilocularis Threonyl tRNA synthetase, C 0.0032 0.0068 0.0158
Echinococcus granulosus pyruvate kinase 0.0019 0.0015 0.0034
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0091 0.0393
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0066 0.0866
Entamoeba histolytica hypothetical protein 0.0072 0.0235 0.1487
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0173 0.0661 0.2866
Trichomonas vaginalis sugar transporter, putative 0.0175 0.067 0.2906
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0066 0.0287
Trypanosoma cruzi hexose transporter, putative 0.0175 0.067 0.8771
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Leishmania major myo-inositol/proton symporter (MIT) 0.008 0.0268 0.351
Onchocerca volvulus 0.008 0.0268 0.4668
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.007 0.0227 0.0983
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0126 0.0464 0.7298
Mycobacterium ulcerans beta-lactamase 0.0041 0.0105 0.147
Brugia malayi aspartic protease BmAsp-1, identical 0.0059 0.018 0.0781
Schistosoma mansoni protein kinase 0.0173 0.0661 0.1093
Plasmodium falciparum plasmepsin VI 0.0059 0.018 0.018
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0105 0.0456
Trypanosoma cruzi trypanothione reductase, putative 0.0026 0.0042 0.0553
Loa Loa (eye worm) aspartyl-tRNA synthetase 0.0019 0.0015 0.0063
Schistosoma mansoni hypothetical protein 0.0245 0.0963 0.1593
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0048 0.0079
Onchocerca volvulus 0.008 0.0268 0.4668
Onchocerca volvulus 0.0041 0.0105 0.1829
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0158
Onchocerca volvulus 0.008 0.0268 0.4668
Leishmania major cytochrome p450-like protein 0.0032 0.0069 0.0899
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.1317 0.8341
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0187
Trypanosoma cruzi glycyl-tRNA synthetase, putative 0.0019 0.0015 0.0195
Mycobacterium ulcerans glycyl-tRNA synthetase 0.0032 0.0068 0.0871
Echinococcus multilocularis histidyl tRNA synthetase 0.0019 0.0015 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0021 0.0024 0.0238
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0032 0.0068 0.0892
Plasmodium vivax calcium-dependent protein kinase, putative 0.0173 0.0661 0.0661
Chlamydia trachomatis lysine--tRNA ligase 0.0126 0.0464 0.7298
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Entamoeba histolytica hypothetical protein 0.0126 0.0464 0.2938
Mycobacterium leprae putative cytochrome p450 0.0021 0.0024 0.0377
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0026 0.0341
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0026 0.0187
Loa Loa (eye worm) hypothetical protein 0.0059 0.018 0.0781
Toxoplasma gondii aspartyl protease ASP3 0.0059 0.018 0.0272
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0021 0.0024 0.0159
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.008 0.0268 0.4118
Echinococcus multilocularis solute carrier family 22 0.008 0.0268 0.0623
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0359 0.1439 0.624
Schistosoma mansoni transient receptor potential channel 4 0.0216 0.084 0.139
Loa Loa (eye worm) sugar transporter 0.0566 0.2306 1
Plasmodium falciparum mitogen-activated protein kinase 2 0.0914 0.3767 0.3767
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.008 0.0268 0.0444
Plasmodium falciparum ataxin-2 like protein, putative 0.0053 0.0159 0.0159
Mycobacterium leprae Probable threonyl-tRNA synthetase ThrS (threonine-tRNA synthetase) (ThrRS) (Threonine-tRNA ligase) 0.0032 0.0068 0.1055
Schistosoma mansoni lamin 0.0083 0.0282 0.0466
Toxoplasma gondii aspartyl protease 0.0059 0.018 0.0272
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0514 0.1194
Plasmodium falciparum plasmepsin VII 0.0059 0.018 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0105 0.0174
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Brugia malayi hypothetical protein 0.0494 0.2008 0.8706
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0114 0.0413 0.4036
Trypanosoma cruzi Aminoacyl-tRNA editing domain containing protein, putative 0.0028 0.0053 0.0689
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.008 0.0268 0.0268
Schistosoma mansoni survival motor neuron protein 0.0101 0.0358 0.0592
Toxoplasma gondii pyruvate kinase PyKII 0.0019 0.0015 0.0022
Echinococcus granulosus synaptic vesicle 2 protein 0.008 0.0268 0.0623
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0026 0.0042 0.045
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0105 0.147
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0566 0.2306 0.5356
Schistosoma mansoni pyruvate kinase 0.0019 0.0015 0.0024
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0021 0.0024 0.0159
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0456
Brugia malayi major facilitator superfamily protein 0.008 0.0268 0.1163
Schistosoma mansoni transient receptor potential channel 0.0216 0.084 0.139
Wolbachia endosymbiont of Brugia malayi histidyl-tRNA synthetase 0.0019 0.0015 0.0006
Trichomonas vaginalis sugar transporter, putative 0.0175 0.067 0.2906
Brugia malayi beta-lactamase 0.0041 0.0105 0.0456
Onchocerca volvulus 0.0083 0.0282 0.4904
Trypanosoma cruzi glucose transporter, putative 0.008 0.0268 0.351
Brugia malayi Major Facilitator Superfamily protein 0.008 0.0268 0.1163
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Trichomonas vaginalis aspartyl/lysyl-tRNA synthetase, putative 0.0019 0.0015 0.0063
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.017 0.0646 0.2802
Brugia malayi Major Facilitator Superfamily protein 0.008 0.0268 0.1163
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.0024 0.0319
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0066 0.0866
Toxoplasma gondii anticodon binding domain-containing protein 0.0019 0.0015 0.0022
Echinococcus multilocularis muscleblind protein 0.0169 0.0641 0.149
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0456
Brugia malayi hypothetical protein 0.0072 0.0235 0.1018
Brugia malayi Pyruvate kinase, M2 isozyme 0.0037 0.0091 0.0393
Mycobacterium tuberculosis Probable dehydrogenase 0.0114 0.0413 0.4036
Plasmodium falciparum calcium-dependent protein kinase 2 0.0173 0.0661 0.0661
Echinococcus granulosus transient receptor potential ion channel A 0.0209 0.081 0.1881
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0105 0.0456
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0053 0.0228
Echinococcus granulosus calcium activated potassium channel 0.0018 0.001 0.0024
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0024 0.0312
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0105 0.0174
Plasmodium vivax aspartate--tRNA ligase, putative 0.0019 0.0015 0.0015
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.0024 0.0057
Echinococcus granulosus lamin dm0 0.0083 0.0282 0.0654
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0235 0.0388
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.0153 0.0575 0.2491
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.0024 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Brugia malayi cytochrome P450 0.0021 0.0024 0.0106
Loa Loa (eye worm) hypothetical protein 0.0173 0.0661 0.2866
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0105 0.0244
Schistosoma mansoni protein kinase 0.0173 0.0661 0.1093
Brugia malayi T-complex protein 1, beta subunit 0.0027 0.0048 0.0208
Trypanosoma cruzi hexose transporter, putative 0.008 0.0268 0.351
Schistosoma mansoni glycyl-tRNA synthetase 0.0032 0.0068 0.0113
Echinococcus multilocularis Sugar transporter ERD6 protein 0.008 0.0268 0.0623
Toxoplasma gondii sugar transporter ST1 0.008 0.0268 0.0404
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0066 0.0154
Echinococcus multilocularis pyruvate kinase 0.0019 0.0015 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0566 0.2306 1
Schistosoma mansoni glucose transport protein 0.0566 0.2306 0.3815
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Brugia malayi Transient-receptor-potential like protein 0.008 0.0272 0.1177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0075 0.0324
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.008 0.0268 0.2622
Loa Loa (eye worm) beta-lactamase 0.0041 0.0105 0.0456
Leishmania major glucose transporter, lmgt2 0.0175 0.067 0.8771
Entamoeba histolytica hypothetical protein 0.0072 0.0235 0.1487
Leishmania major lysyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0035 0.0082
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.0024 0.0319
Schistosoma mansoni sugar transporter 0.008 0.0268 0.0444
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0126 0.0462 0.7144
Brugia malayi hypothetical protein 0.0053 0.0159 0.0688
Entamoeba histolytica histidyl-tRNA synthetase, putative 0.0019 0.0015 0.0094
Schistosoma mansoni transient receptor potential channel 0.0143 0.0534 0.0883
Trichomonas vaginalis glucose transporter, putative 0.0175 0.067 0.2906
Trichomonas vaginalis conserved hypothetical protein 0.0175 0.067 0.2906
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0105 0.147
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0021 0.0024 0.0238
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0173 0.0661 0.1535
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0021 0.0024 0.0159
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0041 0.0105 0.1027
Plasmodium falciparum threonine--tRNA ligase 0.0032 0.0068 0.0068
Trypanosoma cruzi cytochrome P450, putative 0.0032 0.0069 0.0899
Trypanosoma brucei PAB1-binding protein , putative 0.0053 0.0159 0.2076
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0102 0.0237
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Brugia malayi intermediate filament protein 0.0083 0.0282 0.1222
Echinococcus multilocularis GPCR, family 2 0.0114 0.0411 0.0954
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0021 0.0024 0.0238
Loa Loa (eye worm) hypothetical protein 0.0081 0.0275 0.1194
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0069 0.0298
Loa Loa (eye worm) major facilitator superfamily transporter 0.008 0.0268 0.1163
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0026 0.0042 0.0553
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0021 0.0024 0.0159
Brugia malayi follicle stimulating hormone receptor 0.0228 0.089 0.3861
Schistosoma mansoni lysyl-tRNA synthetase 0.0126 0.0464 0.0768
Mycobacterium ulcerans hypothetical protein 0.0041 0.0105 0.147
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Schistosoma mansoni lysyl-tRNA synthetase 0.0126 0.0464 0.0768
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0053 0.0815
Plasmodium vivax glutathione reductase, putative 0.0055 0.0167 0.0167
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Brugia malayi hypothetical protein 0.008 0.0268 0.1163
Trypanosoma brucei pyruvate kinase 1 0.0037 0.0091 0.1187
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0059 0.018 0.0781
Loa Loa (eye worm) hypothetical protein 0.0359 0.1439 0.624
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0026 0.0341
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0041 0.0105 0.1027
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.0514 0.1194
Loa Loa (eye worm) hypothetical protein 0.008 0.0272 0.1177
Brugia malayi Cam kinase protein 1 0.0173 0.0661 0.2866
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0026 0.0042 0.0042
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0126 0.0464 0.6074
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0026 0.0042 0.0553
Brugia malayi Muscleblind-like protein 0.0169 0.0641 0.2781
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Trypanosoma cruzi hexose transporter, putative 0.0096 0.0337 0.4407
Plasmodium falciparum calcium-dependent protein kinase 3 0.0173 0.0661 0.0661
Toxoplasma gondii thioredoxin reductase 0.0055 0.0167 0.0252
Echinococcus granulosus intermediate filament protein 0.0083 0.0282 0.0654
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0091 0.1578
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0121 0.0523
Entamoeba histolytica pyruvate kinase, putative 0.0026 0.0044 0.0275
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0037 0.0091 0.0887
Entamoeba histolytica threonyl-tRNA synthetase, putative 0.0032 0.0068 0.0432
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Entamoeba histolytica hypothetical protein 0.0072 0.0235 0.1487
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Toxoplasma gondii lysine-tRNA ligase 0.0126 0.0464 0.0699
Loa Loa (eye worm) major facilitator superfamily transporter 0.008 0.0268 0.1163
Plasmodium falciparum calcium-dependent protein kinase 5 0.0173 0.0661 0.0661
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0026 0.0043
Toxoplasma gondii NADPH-glutathione reductase 0.0026 0.0042 0.0064
Entamoeba histolytica protein kinase, putative 0.0173 0.0661 0.4185
Brugia malayi Sugar transporter family protein 0.008 0.0268 0.1163
Trypanosoma cruzi asparaginyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0102 0.0237
Mycobacterium ulcerans integral membrane transport protein 0.008 0.0268 0.4118
Brugia malayi Pepsin A precursor 0.0059 0.018 0.0781
Giardia lamblia Pyruvate kinase 0.0019 0.0015 0.0094
Plasmodium falciparum calcium-dependent protein kinase 4 0.0173 0.0661 0.0661
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0173 0.0661 0.0661
Brugia malayi aspartic protease BmAsp-2, identical 0.0059 0.018 0.0781
Trichomonas vaginalis glucose transporter, putative 0.0175 0.067 0.2906
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0085 0.1109
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0021 0.0024 0.0238
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Trypanosoma brucei aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Schistosoma mansoni hypothetical protein 0.0072 0.0235 0.0388
Brugia malayi major facilitator superfamily protein 0.008 0.0268 0.1163
Echinococcus multilocularis pyruvate kinase 0.0037 0.0091 0.0211
Schistosoma mansoni serine/threonine protein kinase 0.0173 0.0661 0.1093
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.017 0.0646 0.1069
Loa Loa (eye worm) hypothetical protein 0.0022 0.0026 0.0113
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0123 0.0534
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0027 0.0048 0.0627
Mycobacterium tuberculosis Probable reductase 0.0114 0.0413 0.4036
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0123 0.1611
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0053 0.0228
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0027 0.0048 0.0208
Mycobacterium tuberculosis Conserved protein 0.0041 0.0105 0.1027
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0456
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0026 0.0042 0.007
Leishmania major hypothetical protein, conserved 0.0041 0.0105 0.1375
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0035 0.0082
Plasmodium falciparum asparagine--tRNA ligase 0.0019 0.0015 0.0015
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0042 0.0553
Onchocerca volvulus 0.008 0.0268 0.4668
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0514 0.085
Treponema pallidum prolyl-tRNA synthetase 0.006 0.0186 0.1316
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Schistosoma mansoni histidyl-tRNA synthetase 0.0019 0.0015 0.0025
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0114 0.0413 0.6389
Loa Loa (eye worm) hypothetical protein 0.017 0.0646 0.2802
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.017 0.0646 0.1069
Giardia lamblia Pyruvate kinase 0.0037 0.0091 0.0574
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0091 0.0393
Toxoplasma gondii sugar transporter ST3 0.008 0.0268 0.0404
Giardia lamblia GTOR 0.0045 0.0123 0.0779
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0021 0.0024 0.0238
Brugia malayi Asparaginyl-tRNA synthetase, cytoplasmic 0.0019 0.0015 0.0063
Brugia malayi Cytochrome P450 family protein 0.0067 0.0218 0.0944
Trypanosoma cruzi PAB1-binding protein , putative 0.0053 0.0159 0.2076
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0105 0.1375
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0059 0.018 0.0781
Leishmania major hypothetical protein, conserved 0.0028 0.0053 0.0689
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0235 0.0545
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Echinococcus multilocularis synaptic vesicle 2 protein 0.008 0.0268 0.0623
Plasmodium falciparum histidine--tRNA ligase, putative 0.0019 0.0015 0.0015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Onchocerca volvulus 0.008 0.0268 0.4668
Echinococcus multilocularis tumor protein p63 0.1042 0.4306 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.0514 0.2229
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0026 0.0042 0.0042
Loa Loa (eye worm) pyruvate kinase 0.0037 0.0091 0.0393
Treponema pallidum NADH oxidase 0.0026 0.0042 0.0213
Mycobacterium tuberculosis Probable thioredoxin reductase TrxB2 (TRXR) (TR) 0.0166 0.0631 0.6164
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0021 0.0024 0.0238
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0021 0.0024 0.0159
Plasmodium falciparum calcium-dependent protein kinase 1 0.0173 0.0661 0.0661
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0021 0.0024 0.0238
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Giardia lamblia Lysyl-tRNA synthetase 0.0126 0.0464 0.2938
Plasmodium vivax sugar transporter, putative 0.008 0.0268 0.0268
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0041 0.0105 0.1027
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Echinococcus granulosus pyruvate kinase 0.0037 0.0091 0.0211
Brugia malayi lysyl-tRNA synthetase 0.0126 0.0464 0.2012
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Onchocerca volvulus 0.008 0.0268 0.4668
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0105 0.0456
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0235 0.0545
Chlamydia trachomatis pyruvate kinase 0.0037 0.0091 0.1236
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0053 0.0228
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0105 0.0456
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0013 0.017
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0026 0.0061
Schistosoma mansoni pyruvate kinase 0.0037 0.0091 0.015
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0066 0.0066
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0066 0.0154
Leishmania major hypothetical protein, conserved 0.008 0.0268 0.351
Trypanosoma cruzi aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Echinococcus granulosus dna polymerase kappa 0.0022 0.0026 0.0061
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0198 0.0764 1
Plasmodium vivax aspartyl proteinase, putative 0.0059 0.018 0.018
Mycobacterium ulcerans sugar transporter 0.008 0.0268 0.4118
Echinococcus multilocularis pyruvate kinase 0.0029 0.0058 0.0134
Schistosoma mansoni cathepsin D (A01 family) 0.0059 0.018 0.0298
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0066 0.0154
Echinococcus multilocularis pyruvate kinase 0.0019 0.0015 0.0034
Leishmania major trypanothione reductase 0.0055 0.0167 0.2192
Giardia lamblia Aspartyl-tRNA synthetase 0.0019 0.0015 0.0092
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.017 0.0646 0.1501
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0123 0.1611
Mycobacterium tuberculosis Probable lipase LipD 0.0041 0.0105 0.1027
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0157
Trypanosoma brucei Aminoacyl-tRNA editing domain containing protein, putative 0.0028 0.0053 0.0689
Trypanosoma cruzi hexose transporter, putative 0.0175 0.067 0.8771
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Echinococcus granulosus thioredoxin glutathione reductase 0.0056 0.017 0.0395
Trypanosoma brucei cytochrome P450, putative 0.0032 0.0069 0.0899
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Trypanosoma cruzi hypothetical protein, conserved 0.0028 0.0053 0.0689
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0105 0.0105
Entamoeba histolytica glycyl-tRNA synthetase, putative 0.0032 0.0068 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0085 0.0367
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0066 0.0647
Trichomonas vaginalis sugar transport protein, putative 0.008 0.0268 0.1163
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0167 0.1637
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0059 0.018 0.0272
Schistosoma mansoni sugar transporter 0.008 0.0268 0.0444
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0066 0.0109
Trypanosoma brucei glucose transporter, putative 0.0175 0.067 0.8771
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0026 0.0042 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0085 0.0367
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0173 0.0661 0.1535
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0021 0.0024 0.0238
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0456
Echinococcus multilocularis lamin dm0 0.0083 0.0282 0.0654
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0026 0.0042 0.0553
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0198 0.0764 0.1152
Brugia malayi hypothetical protein 0.008 0.0268 0.1163
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0123 0.0534
Echinococcus granulosus calcium dependent protein kinase 0.0162 0.0616 0.1431
Schistosoma mansoni memapsin-2 (A01 family) 0.1457 0.6045 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.033 0.1317 0.5713
Loa Loa (eye worm) hypothetical protein 0.0041 0.0105 0.0456
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0021 0.0024 0.0238
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0021 0.0024 0.0159
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0126 0.0464 0.2012
Mycobacterium ulcerans thioredoxin reductase TrxB2 0.0166 0.0631 1
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Loa Loa (eye worm) aspartyl protease 6 0.0059 0.018 0.0781
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0048 0.0079
Treponema pallidum glycyl-tRNA synthetase 0.0019 0.0015 0.0003
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0166 0.0631 0.2734
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Plasmodium vivax glycine--tRNA ligase, putative 0.0032 0.0068 0.0068
Echinococcus multilocularis asparaginyl tRNA synthetase 0.0019 0.0015 0.0034
Loa Loa (eye worm) hypothetical protein 0.004 0.0102 0.0443
Loa Loa (eye worm) intermediate filament protein 0.0083 0.0282 0.1222
Echinococcus multilocularis survival motor neuron protein 1 0.0494 0.2008 0.4663
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0021 0.0024 0.0159
Brugia malayi hypothetical protein 0.0059 0.018 0.0781
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0173 0.0661 0.0997
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0021 0.0024 0.0159
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0123 0.0286
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0228 0.089 0.3861
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0061 0.0265
Trypanosoma cruzi pyruvate kinase 2, putative 0.0037 0.0091 0.1187
Giardia lamblia DNA repair protein RAD52 0.0392 0.1579 1
Giardia lamblia Asparaginyl-tRNA synthetase 0.0019 0.0015 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0268 0.1163
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0111 0.0399 0.1729
Brugia malayi threonyl-tRNA synthetase, cytoplasmic 0.0032 0.0068 0.0296
Onchocerca volvulus 0.0059 0.018 0.3135
Echinococcus multilocularis lamin 0.0083 0.0282 0.0654
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0107 0.0384 0.3757
Echinococcus granulosus Sugar transporter ERD6 protein 0.008 0.0268 0.0623
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0026 0.0255
Plasmodium falciparum plasmepsin X 0.0059 0.018 0.018
Echinococcus multilocularis dna polymerase eta 0.0022 0.0026 0.0061
Schistosoma mansoni aspartyl-tRNA synthetase 0.0019 0.0015 0.0024
Leishmania major protein kinase, putative 0.0173 0.0661 0.865
Plasmodium vivax asparagine--tRNA ligase, putative 0.0019 0.0015 0.0015
Echinococcus granulosus histidyl tRNA synthetase 0.0019 0.0015 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0021 0.0024 0.0238
Plasmodium vivax pyruvate kinase, putative 0.0037 0.0091 0.0091
Schistosoma mansoni sugar transporter 0.008 0.0268 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0036 0.0158
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0161 0.061 0.9443
Plasmodium vivax CDK-related protein kinase 6, putative 0.24 1 1
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0167 0.2192
Onchocerca volvulus Putative transporter 0.008 0.0268 0.4668
Loa Loa (eye worm) latrophilin receptor protein 2 0.0114 0.0411 0.1781
Mycobacterium ulcerans prolyl-tRNA synthetase 0.006 0.0186 0.2784
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Leishmania major lysyl-tRNA synthetase, putative 0.0126 0.0464 0.6074
Trichomonas vaginalis pyruvate kinase, putative 0.0037 0.0091 0.0393
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0566 0.2306 0.5356
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Trichomonas vaginalis sugar transporter, putative 0.008 0.0268 0.1163
Plasmodium falciparum T-complex protein 1 subunit beta 0.0027 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0032 0.0068 0.0296
Trichomonas vaginalis mercuric reductase, putative 0.0026 0.0042 0.0183
Leishmania major aspartyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Trypanosoma cruzi hexose transporter 0.0175 0.067 0.8771
Mycobacterium tuberculosis Probable lipase LipE 0.0041 0.0105 0.1027
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0123 0.1611
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0114 0.0411 0.1781
Schistosoma mansoni transient receptor potential channel 0.0143 0.0534 0.0883
Brugia malayi Sugar transporter family protein 0.0566 0.2306 1
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0085 0.1109
Giardia lamblia Hexose transporter 0.008 0.0268 0.1698
Onchocerca volvulus 0.008 0.0268 0.4668
Trichomonas vaginalis disulfide oxidoreductase, putative 0.0166 0.0631 0.2734
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0021 0.0024 0.0238
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0059 0.018 0.0781
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0114 0.0413 0.4036
Brugia malayi MH2 domain containing protein 0.0118 0.043 0.1865
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0268 0.1163
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.0024 0.0319
Loa Loa (eye worm) hypothetical protein 0.0059 0.018 0.0781
Loa Loa (eye worm) hypothetical protein 0.017 0.0646 0.2802
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0066 0.0866
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Echinococcus multilocularis asparaginyl tRNA synthetase, cytoplasmic 0.0019 0.0015 0.0034
Loa Loa (eye worm) pyruvate kinase-PB 0.0026 0.0044 0.0189
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0026 0.0165
Leishmania major hypothetical protein, conserved 0.0028 0.0053 0.0689
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0126 0.0464 0.6074
Loa Loa (eye worm) threonyl-tRNA synthetase 0.0032 0.0068 0.0296
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0268 0.1163
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.0514 0.2229
Entamoeba histolytica thioredoxin reductase, putative 0.0166 0.0631 0.3992
Trypanosoma cruzi threonyl-tRNA synthetase, putative 0.0032 0.0068 0.0892
Brugia malayi Cytochrome P450 family protein 0.0032 0.0069 0.0298
Onchocerca volvulus 0.008 0.0268 0.4668
Plasmodium falciparum plasmepsin VIII, putative 0.0059 0.018 0.018
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0026 0.0113
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0021 0.0024 0.0238
Chlamydia trachomatis proline--tRNA ligase 0.006 0.0186 0.2784
Loa Loa (eye worm) hypothetical protein 0.0059 0.018 0.0781
Mycobacterium leprae Probable pyruvate kinase PykA 0.0037 0.0091 0.1403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0047 0.0205
Toxoplasma gondii glycyl-tRNA synthetase 0.0032 0.0068 0.0103
Trichomonas vaginalis chaperonin, putative 0.0027 0.0048 0.0208
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0026 0.0042 0.0553
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0026 0.0341
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0126 0.0462 0.4513
Echinococcus granulosus pyruvate kinase 0.0019 0.0015 0.0034
Trichomonas vaginalis sugar transporter, putative 0.0175 0.067 0.2906
Echinococcus multilocularis short transient receptor potential channel 6 0.0143 0.0534 0.1239
Mycobacterium leprae Probable lipase LipE 0.0041 0.0105 0.1626
Loa Loa (eye worm) hypothetical protein 0.008 0.0268 0.1163
Schistosoma mansoni hypothetical protein 0.0024 0.0035 0.0058
Trypanosoma cruzi hexose transporter, putative 0.0175 0.067 0.8771
Onchocerca volvulus Pyruvate kinase homolog 0.0037 0.0091 0.1578
Wolbachia endosymbiont of Brugia malayi prolyl-tRNA synthetase 0.0032 0.0068 0.0871
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0059 0.018 0.0298
Echinococcus granulosus GPCR family 2 0.0114 0.0411 0.0954
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0161 0.061 0.967
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0021 0.0024 0.0159
Trypanosoma brucei asparaginyl-tRNA synthetase, putative 0.0019 0.0015 0.019
Loa Loa (eye worm) hypothetical protein 0.0037 0.0091 0.0393
Echinococcus multilocularis transient receptor potential ion channel A 0.0209 0.081 0.1881
Brugia malayi Sugar transporter family protein 0.008 0.0268 0.1163
Plasmodium falciparum pyruvate kinase 0.0037 0.0091 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.0514 0.085
Giardia lamblia Prolyl-tRNA synthetase 0.017 0.0646 0.4091
Schistosoma mansoni cytochrome P450 0.0021 0.0024 0.004
Loa Loa (eye worm) hypothetical protein 0.0126 0.0464 0.2012
Mycobacterium ulcerans threonyl-tRNA synthetase 0.0032 0.0068 0.0871
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.033 0.1317 0.8341
Echinococcus multilocularis calcium dependent protein kinase 0.0162 0.0616 0.1431
Toxoplasma gondii histidyl-tRNA synthetase (HisRS), putative 0.0019 0.0015 0.0022
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0021 0.0024 0.0238
Leishmania major cytochrome p450-like protein 0.0021 0.0024 0.0319
Plasmodium falciparum plasmepsin IV 0.0059 0.018 0.018
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.017 0.0646 0.1501
Brugia malayi hypothetical protein 0.008 0.0268 0.1163
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0027 0.0048 0.0079
Plasmodium vivax pyruvate kinase 2, putative 0.0019 0.0015 0.0015
Echinococcus granulosus TRP transient receptor potential channel 0.008 0.0272 0.063
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0026 0.0042 0.0553
Loa Loa (eye worm) hypothetical protein 0.0114 0.0411 0.1781

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) = 0.316227766 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 2.238721139 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.011872336 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 5.623413252 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 19.95262315 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 8.2753 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 20.7865 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (binding) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Fluorescein Labeled MLL-derived Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding. (Class of assay: confirmatory) [Related pubchem assays: 596 ] ChEMBL. No reference
Potency (functional) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 31.5479 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ] ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay; Stimulation with EGF. (Class of assay: confirmatory) [Related pubchem assays: 995 ] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.