Detailed information for compound 1282077

Basic information

Technical information
  • TDR Targets ID: 1282077
  • Name: [3-[[3-(benzotriazol-1-yl)propylamino]methyl] imidazo[1,2-a]pyridin-2-yl]-morpholin-4-ylmet hanone
  • MW: 419.48 | Formula: C22H25N7O2
  • H donors: 1 H acceptors: 4 LogP: 1.77 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nc2n(c1CNCCCn1nnc3c1cccc3)cccc2)N1CCOCC1
  • InChi: 1S/C22H25N7O2/c30-22(27-12-14-31-15-13-27)21-19(28-10-4-3-8-20(28)24-21)16-23-9-5-11-29-18-7-2-1-6-17(18)25-26-29/h1-4,6-8,10,23H,5,9,11-16H2
  • InChiKey: SMGRMUXDBDXERJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [3-[[3-(benzotriazol-1-yl)propylamino]methyl]imidazo[1,2-a]pyridin-2-yl]-morpholino-methanone
  • [3-[[3-(1-benzotriazolyl)propylamino]methyl]-2-imidazo[1,2-a]pyridinyl]-morpholinomethanone
  • [3-[[3-(benzotriazol-1-yl)propylamino]methyl]imidazo[1,2-a]pyridin-2-yl]-morpholin-4-yl-methanone
  • 3-(1H-1,2,3-benzotriazol-1-yl)-N-{[2-(morpholin-4-ylcarbonyl)imidazo[1,2-a]pyridin-3-yl]methyl}propan-1-amine
  • MLS000735884
  • SMR000317455

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ataxin 2 Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Homo sapiens galactosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K01204 alpha-N-acetylgalactosaminidase [EC3.2.1.49], putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Glycoside hydrolase, family 27 Get druggable targets OG5_127620 All targets in OG5_127620
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Toxoplasma gondii melibiase subfamily protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Brugia malayi Melibiase family protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase, putative Get druggable targets OG5_127620 All targets in OG5_127620
Neospora caninum hypothetical protein Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum Alpha-N-acetylgalactosaminidase precursor, putative Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus granulosus Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
Schistosoma japonicum expressed protein Get druggable targets OG5_127620 All targets in OG5_127620
Echinococcus multilocularis Alpha N acetylgalactosaminidase Get druggable targets OG5_127620 All targets in OG5_127620
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0242 0.0616
Brugia malayi Pre-SET motif family protein 0.003 0.0128 0.0199
Loa Loa (eye worm) RecQ helicase 0.0128 0.1354 0.2102
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.0139 0.0195
Brugia malayi RNA, U transporter 1 0.008 0.0758 0.1176
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0229 0.0321
Entamoeba histolytica recQ family helicase, putative 0.0037 0.0223 0.0569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0171 0.0435
Brugia malayi jmjC domain containing protein 0.0096 0.0952 0.1477
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0138 0.1471 0.2058
Echinococcus multilocularis Protein lozenge 0.0054 0.0437 0.0437
Schistosoma mansoni microtubule-associated protein tau 0.0825 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0395 0.0613
Loa Loa (eye worm) runx1 0.0054 0.0437 0.0677
Mycobacterium ulcerans glutaminase 0.0538 0.6444 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.023 0.0357
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0229 0.0229
Echinococcus granulosus transcription factor Dp 1 0.0075 0.0695 0.0695
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0052 0.0403 0.1028
Loa Loa (eye worm) hypothetical protein 0.0076 0.0699 0.1085
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0116 0.0295
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0229 0.0128
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0341 0.0869
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0084 0.0799 0.1119
Brugia malayi MH1 domain containing protein 0.0025 0.0068 0.0106
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.1027 0.1437
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0335 0.3922 1
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0254 0.0254
Echinococcus granulosus snurportin 1 0.0301 0.3502 0.3502
Leishmania major hypothetical protein, conserved 0.003 0.0135 0.0189
Loa Loa (eye worm) hypothetical protein 0.0091 0.0892 0.1384
Brugia malayi regulator of G-protein signaling egl-10 0.0027 0.0102 0.0159
Leishmania major hypothetical protein, conserved 0.003 0.0139 0.0195
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0103
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0178 0.0178
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1297 0.1297
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0892 0.1248
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0123 0.1289 0.1804
Loa Loa (eye worm) acetyltransferase 0.0148 0.1601 0.2485
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0335 0.3922 1
Brugia malayi beta-lactamase 0.0038 0.0229 0.0355
Echinococcus granulosus geminin 0.0166 0.1821 0.1821
Onchocerca volvulus 0.0433 0.5144 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0125 0.1309 0.1309
Leishmania major mitochondrial DNA polymerase beta 0.0595 0.7145 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0229 0.0355
Toxoplasma gondii eukaryotic initiation factor-4E, putative 0.0034 0.018 0.046
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0229 0.0355
Schistosoma mansoni hypothetical protein 0.0058 0.0477 0.0477
Brugia malayi jmjC domain containing protein 0.0025 0.0066 0.0103
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0557 0.0557
Echinococcus multilocularis regulator of G protein signaling 7 0.0027 0.0102 0.0102
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0034 0.018 0.046
Echinococcus granulosus peregrin 0.0037 0.0217 0.0217
Trypanosoma brucei unspecified product 0.0086 0.0829 0.116
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0178 0.0178
Loa Loa (eye worm) hypothetical protein 0.0053 0.0421 0.0654
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0242 0.0338
Leishmania major small ubiquitin protein, putative 0.0051 0.0395 0.0553
Echinococcus granulosus eukaryotic translation initiation factor 4E 0.0034 0.018 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.099 0.1386
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0341 0.0477
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.018 0.028
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0229 0.0584
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0335 0.3922 0.5489
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0066 0.0093
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0115 0.0115
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0171 0.0435
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0116 0.0116
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0045 0.0064
Trypanosoma brucei DNA damage repair protein, putative 0.0039 0.0242 0.0338
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0229 0.0355
Brugia malayi beta-lactamase family protein 0.0038 0.0229 0.0355
Brugia malayi Importin beta-1 subunit 0.0028 0.0112 0.0173
Loa Loa (eye worm) hypothetical protein 0.0148 0.1598 0.248
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.018 0.028
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0042 0.0284 0.0284
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0171 0.0435
Echinococcus granulosus smad 0.0025 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0027 0.0102 0.0159
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.007
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0027
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0341 0.0341
Schistosoma mansoni hypothetical protein 0.0041 0.0266 0.0266
Loa Loa (eye worm) bromodomain containing protein 0.0038 0.0237 0.0367
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0025 0.0066 0.0169
Trypanosoma brucei ISWI complex protein 0.003 0.0135 0.0189
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0343 0.0875
Trypanosoma brucei phosphoglycerate kinase 0.0335 0.3922 0.5489
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0081 0.0126
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0066 0.0066
Trypanosoma cruzi ISWI complex protein 0.003 0.0135 0.0189
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0242 0.0338
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.0723
Trichomonas vaginalis ubiquitin, putative 0.0032 0.0153 0.0237
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0081 0.0081
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0242 0.0616
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0557 0.0557
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0341 0.0529
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0081 0.0208
Plasmodium vivax importin-beta 2, putative 0.0028 0.0112 0.0285
Trypanosoma brucei phosphoglycerate kinase 0.0123 0.1289 0.1804
Brugia malayi Phosphoglycerate kinase 0.0335 0.3922 0.6086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0229 0.0355
Brugia malayi MH2 domain containing protein 0.0025 0.0068 0.0106
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0177 0.196 0.3041
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.196 0.2743
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.099 0.1386
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0341 0.0341
Mycobacterium leprae Probable lipase LipE 0.0038 0.0229 0.0128
Loa Loa (eye worm) glutaminase 2 0.0538 0.6444 1
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0194 0.0496
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0081 0.0208
Trichomonas vaginalis ran, putative 0.0021 0.0019 0.003
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0302
Echinococcus granulosus regulator of G protein signaling 7 0.0027 0.0102 0.0102
Echinococcus granulosus bloom syndrome protein 0.0128 0.1354 0.1354
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.0341 0.0869
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0242 0.0616
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0181 0.0461
Brugia malayi hypothetical protein 0.0042 0.0284 0.044
Brugia malayi ImpB/MucB/SamB family protein 0.0125 0.1309 0.2032
Loa Loa (eye worm) hypothetical protein 0.0028 0.0112 0.0173
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0019 0.0049
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0068 0.0106
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0335 0.3922 0.6086
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Echinococcus granulosus tumor protein p63 0.068 0.8199 0.8199
Trypanosoma brucei DNA polymerase IV, putative 0.0164 0.1798 0.2517
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0335 0.3922 1
Echinococcus granulosus regulator of G protein signaling 7 0.0027 0.0102 0.0102
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.023 0.0322
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0421 0.0421
Schistosoma mansoni ran 0.0021 0.0019 0.0019
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0027
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.023 0.0322
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.1601 0.2485
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0229 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0545 0.0545
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0066 0.0103
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0493 0.0765
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Echinococcus granulosus ubiquitin 0.0032 0.0153 0.0153
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.1493 0.1493
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0341 0.0529
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0066 0.0066
Schistosoma mansoni flap endonuclease-1 0.0023 0.0051 0.0051
Echinococcus multilocularis dna polymerase eta 0.0175 0.1932 0.1932
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0595 0.7145 1
Onchocerca volvulus 0.0099 0.0996 0.1752
Brugia malayi hypothetical protein 0.003 0.0139 0.0216
Schistosoma mansoni inositol monophosphatase 0.0038 0.023 0.023
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0302
Trypanosoma cruzi small ubiquitin protein, putative 0.0051 0.0395 0.0553
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0335 0.3922 0.5489
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0076 0.0703 0.1793
Brugia malayi jmjC domain containing protein 0.0025 0.0066 0.0103
Schistosoma mansoni ran 0.0021 0.0019 0.0019
Echinococcus multilocularis ubiquitin 0.0032 0.0153 0.0153
Leishmania major hypothetical protein, conserved 0.0025 0.0066 0.0093
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.0952 0.1477
Loa Loa (eye worm) hypothetical protein 0.0076 0.0703 0.1091
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.013 0.1375 0.2134
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0302
Loa Loa (eye worm) transcription factor SMAD2 0.0363 0.4266 0.662
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0341 0.0448
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0557 0.0865
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0343 0.0875
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0421 0.0421
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0341 0.0477
Echinococcus granulosus survival motor neuron protein 1 0.0283 0.327 0.327
Trichomonas vaginalis esterase, putative 0.0038 0.0229 0.0355
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0081 0.0208
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0952 0.0952
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0044 0.0312 0.0312
Echinococcus multilocularis snurportin 1 0.0301 0.3502 0.3502
Schistosoma mansoni DNA polymerase eta 0.0175 0.1932 0.1932
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1297 0.1297
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Giardia lamblia Sentrin 0.0051 0.0395 0.1007
Mycobacterium tuberculosis Conserved protein 0.0038 0.0229 0.0584
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.0799 0.1119
Treponema pallidum phosphoglycerate kinase 0.0335 0.3922 1
Loa Loa (eye worm) hypothetical protein 0.0433 0.5144 0.7982
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0076 0.0703 0.1793
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0099 0.099 0.1386
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0341 0.0529
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0229 0.0584
Brugia malayi hypothetical protein 0.002 0.0005 0.0008
Brugia malayi mbt repeat family protein 0.0047 0.0341 0.0529
Brugia malayi Bromodomain containing protein 0.0151 0.1639 0.2543
Loa Loa (eye worm) hypothetical protein 0.0291 0.3379 0.5243
Entamoeba histolytica deoxycytidyl transferase, putative 0.0125 0.1309 0.3339
Echinococcus granulosus zinc finger protein 0.0042 0.0284 0.0284
Loa Loa (eye worm) hypothetical protein 0.003 0.0139 0.0216
Schistosoma mansoni DNA helicase recq5 0.0076 0.0703 0.0703
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.196 0.2743
Loa Loa (eye worm) hypothetical protein 0.0039 0.0241 0.0375
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.0341 0.0529
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0171 0.0435
Plasmodium vivax SET domain protein, putative 0.003 0.0128 0.0327
Loa Loa (eye worm) hypothetical protein 0.0433 0.5144 0.7982
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0241 0.0338
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0341 0.0341
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0557 0.0557
Brugia malayi translation initiation factor 4E 0.0034 0.018 0.028
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.023 0.0357
Loa Loa (eye worm) hypothetical protein 0.0086 0.0832 0.1291
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0229 0.0355
Plasmodium falciparum flap endonuclease 1 0.0026 0.0081 0.0208
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0229 0.0229
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0229 0.0355
Schistosoma mansoni DNA helicase recq1 0.0076 0.0703 0.0703
Trypanosoma cruzi ISWI complex protein 0.003 0.0135 0.0189
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.0341 0.0529
Brugia malayi Inositol-1 0.0038 0.023 0.0357
Schistosoma mansoni lozenge 0.0054 0.0437 0.0437
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.196 0.2743
Schistosoma mansoni transcription factor LCR-F1 0.0042 0.0284 0.0284
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0421 0.0421
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0034 0.018 0.0252
Plasmodium falciparum importin beta, putative 0.0028 0.0112 0.0285
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0076 0.0703 0.1091
Leishmania major hypothetical protein, conserved 0.0038 0.0229 0.0321
Chlamydia trachomatis phosphoglycerate kinase 0.0335 0.3922 1
Schistosoma mansoni smad 0.0025 0.0068 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Brugia malayi TAR-binding protein 0.0064 0.0557 0.0865
Loa Loa (eye worm) MBCTL1 0.0053 0.0421 0.0654
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0242 0.0616
Trypanosoma brucei DNA polymerase IV, putative 0.0177 0.196 0.2743
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0786 0.0786
Echinococcus granulosus histone lysine methyltransferase setb 0.0063 0.0545 0.0545
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0117 0.122 0.311
Trypanosoma cruzi DNA polymerase kappa, putative 0.0177 0.196 0.2743
Echinococcus multilocularis phosphoglycerate kinase 1 0.0335 0.3922 0.3922
Schistosoma mansoni smad1 5 8 and 0.0025 0.0068 0.0068
Schistosoma mansoni terminal deoxycytidyl transferase 0.0125 0.1309 0.1309
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0121 0.1264 0.1264
Toxoplasma gondii ABC1 family protein 0.0038 0.0229 0.0584
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0229 0.0584
Schistosoma mansoni Smad4 0.0025 0.0068 0.0068
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0229 0.0355
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0229 0.0355
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.023 0.0322
Loa Loa (eye worm) Smad1 0.0025 0.0068 0.0106
Trypanosoma cruzi DNA damage repair protein, putative 0.0039 0.0242 0.0338
Mycobacterium tuberculosis Conserved hypothetical protein 0.0313 0.365 0.9307
Onchocerca volvulus 0.0235 0.2674 0.5087
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0084 0.0799 0.1119
Echinococcus granulosus flap endonuclease 1 0.0026 0.0081 0.0081
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0047 0.0341 0.0529
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.1955 0.3658
Echinococcus multilocularis peregrin 0.0037 0.0217 0.0217
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0123 0.1289 0.1804
Echinococcus multilocularis expressed protein 0.0365 0.4298 0.4298
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.0066 0.0169
Mycobacterium tuberculosis Conserved protein 0.0038 0.0229 0.0584
Schistosoma mansoni DNA polymerase IV / kappa 0.0039 0.0242 0.0242
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0112 0.0156
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0194 0.0496
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0341 0.0529
Brugia malayi hypothetical protein 0.0433 0.5144 0.7982
Schistosoma mansoni jumonji domain containing protein 0.0132 0.1398 0.1398
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0229 0.0321
Trichomonas vaginalis DNA helicase recq, putative 0.0087 0.0838 0.13
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0082 0.0786 0.1219
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0194 0.0302
Mycobacterium ulcerans hypothetical protein 0.0038 0.0229 0.0355
Treponema pallidum ATP-dependent DNA helicase 0.0039 0.0241 0.0616
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0076 0.0703 0.0703
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0188 0.2094 0.2094
Loa Loa (eye worm) hypothetical protein 0.0177 0.1955 0.3034
Onchocerca volvulus Huntingtin homolog 0.0148 0.1598 0.2949
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0068 0.0068
Echinococcus multilocularis microtubule associated protein 2 0.0825 1 1
Echinococcus granulosus phd:f box containing protein 0.0025 0.0066 0.0066
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0139 0.0355
Giardia lamblia Phosphoglycerate kinase 0.0335 0.3922 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0076 0.0703 0.1091
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0045 0.007
Loa Loa (eye worm) SMO-1 protein 0.0051 0.0395 0.0613
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0066 0.0066
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.013 0.1375 0.1925
Echinococcus multilocularis eukaryotic translation initiation factor 4E 0.0034 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0302
Echinococcus granulosus phosphoglycerate kinase 1 0.0335 0.3922 0.3922
Entamoeba histolytica phosphoglycerate kinase, putative 0.0335 0.3922 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0066 0.0066
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.023 0.023
Brugia malayi Bromodomain containing protein 0.0079 0.0741 0.115
Brugia malayi beta-lactamase family protein 0.0038 0.0229 0.0355
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.008 0.0758 0.1932
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0112 0.0156
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0076 0.0703 0.1793
Echinococcus granulosus jumonji domain containing protein 0.004 0.0254 0.0254
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0128 0.0128
Brugia malayi Bloom's syndrome protein homolog 0.0128 0.1354 0.2102
Schistosoma mansoni importin beta-1 0.0028 0.0112 0.0112
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0281 0.3256 0.4557
Echinococcus granulosus Small ubiquitin modifier 2 0.0051 0.0395 0.0395
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0229 0.0584
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0229 0.0584
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.0341 0.0869
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0124 0.1297 0.1297
Loa Loa (eye worm) hypothetical protein 0.0087 0.0848 0.1315
Schistosoma mansoni zinc finger protein 0.0042 0.0284 0.0284
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.064 0.064
Entamoeba histolytica recQ family helicase, putative 0.0087 0.0838 0.2137
Echinococcus granulosus importin subunit beta 1 0.0028 0.0112 0.0112
Schistosoma mansoni smad1 5 8 and 0.0025 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0335 0.3922 0.6086
Brugia malayi N-terminal motif family protein 0.0177 0.1955 0.3034
Brugia malayi RNA binding protein 0.0064 0.0557 0.0865
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0051 0.0395 0.0395
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0557 0.0557
Schistosoma mansoni hypothetical protein 0.0301 0.3502 0.3502
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0087 0.0838 0.1173
Brugia malayi Phosphoglycerate kinase 0.0123 0.1289 0.2
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0128 0.0128
Echinococcus granulosus Smad4 0.0025 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0047 0.0341 0.0529
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0116 0.0179
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1297 0.1297
Brugia malayi hypothetical protein 0.0283 0.327 0.5074
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0178 0.0178
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0027 0.0102 0.0159
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.013 0.1375 0.1375
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.013 0.1375 0.1375
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0124 0.1297 0.1297
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0477 0.074
Leishmania major phosphoglycerate kinase C, glycosomal 0.0335 0.3922 0.5489
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0123 0.1289 0.1804
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0081 0.0114
Loa Loa (eye worm) hypothetical protein 0.0099 0.0996 0.1546
Brugia malayi glutaminase DH11.1 0.0538 0.6444 1
Brugia malayi MH2 domain containing protein 0.0025 0.0068 0.0106
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0066 0.0093
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0128 0.0327
Brugia malayi jmjC domain containing protein 0.0025 0.0066 0.0103
Schistosoma mansoni eukaryotic translation initiation factor 4e 0.0034 0.018 0.018
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0068 0.0068
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0113 0.0113
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.3502 0.5434
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.013 0.1375 0.2134
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.023 0.0587
Trypanosoma cruzi DNA damage repair protein, putative 0.0039 0.0242 0.0338
Loa Loa (eye worm) hypothetical protein 0.0038 0.0229 0.0355
Schistosoma mansoni bromodomain containing protein 0.0128 0.1352 0.1352
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.1601 0.1601
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0341 0.0341
Entamoeba histolytica hypothetical protein 0.0032 0.0153 0.0389
Mycobacterium ulcerans phosphoglycerate kinase 0.0335 0.3922 0.6086
Schistosoma mansoni hypothetical protein 0.0042 0.0284 0.0284
Trypanosoma cruzi small ubiquitin protein, putative 0.0051 0.0395 0.0553
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0068 0.0106
Onchocerca volvulus 0.003 0.0128 0.0025
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.023 0.0357
Brugia malayi polk-prov protein 0.0091 0.0892 0.1384
Trypanosoma brucei chrX additional, unordered contigs 0.0039 0.0242 0.0338
Schistosoma mansoni survival motor neuron protein 0.0058 0.0477 0.0477
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0194 0.0496
Schistosoma mansoni smad1 5 8 and 0.0025 0.0068 0.0068
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.018 0.028
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0087 0.0838 0.1173
Leishmania major DNA damage repair protein, putative 0.0039 0.0242 0.0338
Entamoeba histolytica eukaryotic translation initiation factor 4E, putative 0.0034 0.018 0.046
Trypanosoma cruzi DNA polymerase eta, putative 0.0089 0.0865 0.121
Schistosoma mansoni blooms syndrome DNA helicase 0.009 0.0874 0.0874
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.023 0.0357
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.0952 0.0952
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0123 0.1289 0.1804
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0019 0.0049
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0079 0.074 0.1885
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0229 0.0355
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.013 0.1375 0.3506
Echinococcus multilocularis survival motor neuron protein 1 0.0283 0.327 0.327
Echinococcus granulosus fetal alzheimer antigen falz 0.0044 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0283 0.327 0.5074
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.1375 0.1925
Schistosoma mansoni inositol monophosphatase 0.0038 0.023 0.023
Giardia lamblia DINP protein human, muc B family 0.0138 0.1471 0.375
Giardia lamblia Sgs1 DNA helicase, putative 0.0076 0.0703 0.1793
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0066 0.0066
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0229 0.0355
Plasmodium falciparum small ubiquitin-related modifier 0.0051 0.0395 0.1007
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0341 0.0341
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0123 0.1289 0.1804
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0076 0.0703 0.1091
Plasmodium vivax small ubiquitin-related modifier, putative 0.0051 0.0395 0.1007
Entamoeba histolytica Ran family GTPase 0.0021 0.0019 0.0049
Trypanosoma brucei Eukaryotic translation initiation factor 4E-1 0.0034 0.018 0.0252
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.003
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0116 0.0116
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0139 0.0355
Mycobacterium ulcerans hypothetical protein 0.0039 0.0242 0.0375
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0066 0.0066
Onchocerca volvulus 0.0032 0.0153 0.0074
Brugia malayi Ubiquitin-like protein SMT3 0.0051 0.0395 0.0613
Loa Loa (eye worm) MH2 domain-containing protein 0.0363 0.4266 0.662
Onchocerca volvulus 0.0047 0.0341 0.0448
Echinococcus granulosus expressed protein 0.0365 0.4298 0.4298
Echinococcus multilocularis smad 0.0025 0.0068 0.0068
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0229 0.0584
Loa Loa (eye worm) hypothetical protein 0.0175 0.1932 0.2998
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0084 0.0801 0.1243
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.0341 0.0869
Loa Loa (eye worm) hypothetical protein 0.0047 0.0341 0.0529
Schistosoma mansoni eyes absent homolog 0.0086 0.0832 0.0832
Loa Loa (eye worm) hypothetical protein 0.0038 0.0229 0.0355
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.0341 0.0529
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0066 0.0066
Brugia malayi jmjC domain containing protein 0.0151 0.1636 0.2539
Trypanosoma brucei phosphoglycerate kinase 0.0335 0.3922 0.5489
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0081 0.0208
Loa Loa (eye worm) hypothetical protein 0.0032 0.0153 0.0237
Brugia malayi hypothetical protein 0.0148 0.1598 0.248
Leishmania major GTP-binding protein, putative 0.0021 0.0019 0.0027
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.0723
Mycobacterium tuberculosis Conserved hypothetical protein 0.0125 0.1309 0.3339
Loa Loa (eye worm) hypothetical protein 0.0148 0.1598 0.248
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0242 0.0338
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0545 0.0545
Trypanosoma brucei DNA damage repair protein, putative 0.0039 0.0242 0.0338
Loa Loa (eye worm) hypothetical protein 0.0064 0.0559 0.0868
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0343 0.0533
Brugia malayi ImpB/MucB/SamB family protein 0.0175 0.1932 0.2998
Toxoplasma gondii small ubiquitin family modifier, putative 0.0051 0.0395 0.1007
Trypanosoma brucei DNA polymerase IV, putative 0.0177 0.196 0.2743
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0084 0.0799 0.1119
Echinococcus multilocularis Smad4 0.0025 0.0068 0.0068
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0139 0.0195
Schistosoma mansoni hypothetical protein 0.0288 0.3333 0.3333
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.232 0.36
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0335 0.3922 0.6086
Loa Loa (eye worm) hypothetical protein 0.0038 0.0229 0.0355
Trichomonas vaginalis glutaminase, putative 0.0538 0.6444 1
Toxoplasma gondii hypothetical protein 0.0096 0.0952 0.2428
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.013 0.1375 0.1375
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.1636 0.1636
Leishmania major phosphoglycerate kinase B, cytosolic 0.0335 0.3922 0.5489
Brugia malayi Smad1 0.0025 0.0068 0.0106
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0042 0.0284 0.0284
Leishmania major eukaryotic translation initiation factor-like protein 0.0034 0.018 0.0252
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0112 0.0285
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0039 0.0241 0.0616
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0066 0.0066
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0557 0.0865
Trichomonas vaginalis set domain proteins, putative 0.0235 0.2674 0.4149
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.0341 0.0529
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0089 0.0865 0.2204
Plasmodium falciparum DNA repair protein REV1, putative 0.0039 0.0242 0.0616
Loa Loa (eye worm) hypothetical protein 0.0038 0.0229 0.0355
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0076 0.0703 0.0703
Mycobacterium ulcerans DNA polymerase IV 0.0177 0.196 0.3041
Loa Loa (eye worm) RNA binding protein 0.0064 0.0557 0.0865
Plasmodium falciparum phosphoglycerate kinase 0.0335 0.3922 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.0179
Trypanosoma brucei DNA polymerase eta, putative 0.0175 0.1932 0.2704
Plasmodium falciparum phd finger protein, putative 0.0029 0.0116 0.0295
Echinococcus multilocularis geminin 0.0166 0.1821 0.1821
Echinococcus granulosus dna polymerase kappa 0.0177 0.196 0.196
Onchocerca volvulus 0.0038 0.0229 0.0226
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0125 0.1309 0.1309
Schistosoma mansoni phosphoglycerate kinase 0.0335 0.3922 0.3922
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.3256 0.4557
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0112 0.0112
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0341 0.0341
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.0139 0.0195
Trypanosoma cruzi Eukaryotic translation initiation factor 4E-1 0.0034 0.018 0.0252
Echinococcus multilocularis zinc finger protein 0.0042 0.0284 0.0284
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0128 0.0128
Trypanosoma brucei unspecified product 0.0164 0.1798 0.2517
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.1375 0.1925
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0025 0.0066 0.0169
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0019 0.0027
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0066 0.0103
Loa Loa (eye worm) hypothetical protein 0.0025 0.0066 0.0103
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0125 0.1309 0.2032
Echinococcus multilocularis tumor protein p63 0.068 0.8199 0.8199
Brugia malayi Melibiase family protein 0.0082 0.0786 0.1219
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0082 0.0786 0.0786
Brugia malayi PHD-finger family protein 0.0029 0.0116 0.0179
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0229 0.0584
Trypanosoma brucei DNA polymerase kappa, putative 0.0138 0.1471 0.2058
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0076 0.0703 0.0703
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0139 0.0355
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.013 0.1375 0.1925
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0343 0.0875
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.1601 0.1601
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0595 0.7145 1
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0242 0.0338
Brugia malayi Flap endonuclease-1 0.0026 0.0081 0.0126
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.023 0.0587
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0068 0.0068
Echinococcus multilocularis Small ubiquitin modifier 2 0.0051 0.0395 0.0395
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.1636 0.1636
Schistosoma mansoni hypothetical protein 0.0166 0.1821 0.1821
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0066 0.0066
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0229 0.0229
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0343 0.0343
Trypanosoma cruzi DNA polymerase eta, putative 0.0175 0.1932 0.2704
Echinococcus multilocularis dna polymerase kappa 0.0177 0.196 0.196
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0557 0.0557
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0178 0.0178
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0113 0.0113
Schistosoma mansoni glutaminase 0.0538 0.6444 0.6444
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.275 0.701
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.0341 0.0529
Leishmania major importin beta-1 subunit, putative 0.0023 0.0045 0.0064
Leishmania major DNA polymerase kappa, putative 0.0039 0.0242 0.0338
Schistosoma mansoni blooms syndrome DNA helicase 0.0039 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0047 0.0341 0.0529
Mycobacterium ulcerans DNA polymerase IV 0.0177 0.196 0.3041
Mycobacterium ulcerans beta-lactamase 0.0038 0.0229 0.0355
Echinococcus multilocularis transcription factor Dp 1 0.0075 0.0695 0.0695
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0229 0.0355
Echinococcus granulosus tar DNA binding protein 0.0064 0.0557 0.0557
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0188 0.2094 0.2094
Plasmodium vivax DNA repair protein REV1, putative 0.0039 0.0242 0.0616
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0341 0.0529
Plasmodium vivax ATP-dependent DNA helicase Q1, putative 0.0037 0.0223 0.0569
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.0952 0.0952
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0266 0.0412
Leishmania major DNA polymerase eta, putative 0.0175 0.1932 0.2704
Plasmodium vivax phosphoglycerate kinase, putative 0.0335 0.3922 1
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0068 0.0068
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0116 0.0116
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.023 0.0322
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0229 0.0321
Schistosoma mansoni z-protein (S1r protein) 0.0027 0.0102 0.0102
Trypanosoma brucei phosphoglycerate kinase, putative 0.0123 0.1289 0.1804
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.0723
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0595 0.7145 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.0905 0.0905
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0124 0.1297 0.1297
Brugia malayi jmjC domain containing protein 0.0025 0.0066 0.0103
Brugia malayi Bromodomain containing protein 0.0037 0.0217 0.0337
Schistosoma mansoni hypothetical protein 0.003 0.0135 0.0135
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0139 0.0355
Schistosoma mansoni hypothetical protein 0.0166 0.1821 0.1821
Brugia malayi hypothetical protein 0.0086 0.0832 0.1291
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0066 0.0066
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0081 0.0126
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0124 0.1297 0.1297
Brugia malayi MH2 domain containing protein 0.0363 0.4266 0.662
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0066 0.0103
Entamoeba histolytica hypothetical protein 0.0042 0.0284 0.0723
Trypanosoma brucei DNA polymerase kappa, putative 0.0091 0.0892 0.1248
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0557 0.0865
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0335 0.3922 1
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.3256 0.4557
Mycobacterium ulcerans hypothetical protein 0.0047 0.0341 0.0529
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0123 0.1289 0.1804
Entamoeba histolytica ubiquitin like protein 0.0051 0.0395 0.1007
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0116 0.0295
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.0341 0.0477
Trichomonas vaginalis DNA helicase recq, putative 0.0128 0.1354 0.2102
Onchocerca volvulus 0.0047 0.0341 0.0448
Giardia lamblia DNA damage repair protein 0.0039 0.0242 0.0616
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0066 0.0066
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0421 0.0421
Entamoeba histolytica recQ family DNA helicase 0.0039 0.0241 0.0616
Echinococcus multilocularis regulator of G protein signaling 7 0.0027 0.0102 0.0102
Trichomonas vaginalis eukaryotic translation initiation factor 4E, putative 0.0034 0.018 0.028
Plasmodium vivax JmjC domain containing protein 0.0025 0.0066 0.0169
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0343 0.0533
Onchocerca volvulus 0.0038 0.0229 0.0226
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0341 0.0341
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0125 0.1309 0.1309
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0066 0.0066
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0076 0.0703 0.0703
Echinococcus multilocularis bloom syndrome protein 0.0128 0.1354 0.1354
Schistosoma mansoni zinc finger protein 0.003 0.0135 0.0135
Mycobacterium ulcerans hypothetical protein 0.0313 0.365 0.5665
Schistosoma mansoni regulator of G protein signaling 0.0027 0.0102 0.0102
Onchocerca volvulus Huntingtin homolog 0.0148 0.1598 0.2949
Schistosoma mansoni hypothetical protein 0.0029 0.0116 0.0116
Trypanosoma brucei small ubiquitin-related modifier 0.0051 0.0395 0.0553
Brugia malayi PHD-finger family protein 0.0053 0.0414 0.0642
Onchocerca volvulus 0.0058 0.0477 0.0719
Leishmania major DNA polymerase eta, putative 0.0089 0.0865 0.121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0341 0.0427
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0087 0.0838 0.1173
Loa Loa (eye worm) hypothetical protein 0.0086 0.0832 0.1291
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0341 0.0529
Schistosoma mansoni phosphoglycerate kinase 0.0335 0.3922 0.3922
Loa Loa (eye worm) inositol-1 0.0038 0.023 0.0357
Brugia malayi hypothetical protein 0.0032 0.0153 0.0237
Loa Loa (eye worm) hypothetical protein 0.0082 0.0786 0.1219
Loa Loa (eye worm) translation initiation factor 4E 0.0034 0.018 0.028
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0421 0.0421
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0039 0.0241 0.0338
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.064 0.064
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0153 0.0237
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0049
Mycobacterium ulcerans lipase LipD 0.0038 0.0229 0.0355
Leishmania major eukaryotic translation initiation factor eIF-4E, putative 0.0034 0.018 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0229 0.0584
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.007
Loa Loa (eye worm) hypothetical protein 0.0063 0.0545 0.0846
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0996 0.0996
Loa Loa (eye worm) glutaminase 0.0538 0.6444 1
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0044 0.0312 0.0312
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0121 0.1264 0.1264
Trypanosoma brucei unspecified product 0.0086 0.0829 0.116
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.0341 0.0869
Giardia lamblia PHD finger protein 15 0.0029 0.0116 0.0295
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0138 0.1471 0.375
Brugia malayi Pre-SET motif family protein 0.0206 0.232 0.36
Trypanosoma brucei DNA polymerase kappa, putative 0.0177 0.196 0.2743
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0116 0.0295
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.0341 0.0427
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.0049
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.023 0.0587
Brugia malayi MH1 domain containing protein 0.0025 0.0068 0.0106
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0081 0.0114
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0063 0.0545 0.0545
Brugia malayi mbt repeat family protein 0.0047 0.0341 0.0529
Loa Loa (eye worm) hypothetical protein 0.0035 0.0194 0.0302
Mycobacterium tuberculosis Conserved protein 0.0038 0.0229 0.0584
Loa Loa (eye worm) hypothetical protein 0.0139 0.149 0.2312
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0066 0.0093
Trichomonas vaginalis DNA helicase recq1, putative 0.0128 0.1354 0.2102
Entamoeba histolytica hypothetical protein 0.0023 0.0045 0.0116
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0421 0.0654
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0081 0.0114
Leishmania major eukaryotic translation initiation factor-like 0.0034 0.018 0.0252
Loa Loa (eye worm) beta-lactamase 0.0038 0.0229 0.0355
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0019 0.003
Onchocerca volvulus 0.0038 0.0229 0.0226
Trichomonas vaginalis DNA polymerase eta, putative 0.0177 0.196 0.3041
Echinococcus granulosus dna polymerase eta 0.0175 0.1932 0.1932
Leishmania major DNA polymerase kappa, putative 0.0138 0.1471 0.2058
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0335 0.3922 1
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.023 0.023
Toxoplasma gondii melibiase subfamily protein 0.0124 0.1297 0.3307

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.0891 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 1.2589 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS Assay for Inhibitors of Human alpha-Galactosidase at pH 4.5. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 50.1187 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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