Detailed information for compound 1328553

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 347.41 | Formula: C21H21N3O2
  • H donors: 2 H acceptors: 2 LogP: 3.23 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1C)C)CNC(=O)c1cccc(c1)n1cccc1
  • InChi: 1S/C21H21N3O2/c1-15-7-5-10-19(16(15)2)23-20(25)14-22-21(26)17-8-6-9-18(13-17)24-11-3-4-12-24/h3-13H,14H2,1-2H3,(H,22,26)(H,23,25)
  • InChiKey: IZOTWPLGKFSDLX-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens polymerase (DNA directed) iota Starlite/ChEMBL No references
Homo sapiens myeloid cell leukemia 1 Starlite/ChEMBL No references
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens phosphatidylinositol-5-phosphate 4-kinase, type II, alpha Starlite/ChEMBL No references
Homo sapiens Werner syndrome, RecQ helicase-like Starlite/ChEMBL No references
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific demethylase 4A Starlite/ChEMBL No references
Homo sapiens caspase 6, apoptosis-related cysteine peptidase Starlite/ChEMBL No references
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pip kinase 2 Get druggable targets OG5_131617 All targets in OG5_131617
Echinococcus granulosus ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Theileria parva hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium falciparum NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Probable JmjC domain-containing histone demethylation protein 3B, putative Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) RecQ helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Trypanosoma cruzi hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma brucei gambiense ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis Transcription factor, JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva nuclear LIM interactor-interacting factor 1, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Nuclear LIM interactor-interacting factor 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K01090 protein phosphatase [EC3.1.3.16], putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania donovani dullard-like phosphatase domain containing protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium berghei NLI interacting factor-like phosphatase Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Get druggable targets OG5_127075 All targets in OG5_127075
Neospora caninum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum JmjC domain-containing histone demethylation protein 3C, putative Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium yoelii hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum CTD small phosphatase-like protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis ATP dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii Dullard family phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense TFIIF-stimulated CTD phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania mexicana hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Babesia bovis Dullard-like phosphatase domain containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii ATP-dependent DNA helicase-related Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Bloom's syndrome protein homolog Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium knowlesi NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) jmjC domain-containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131617 All targets in OG5_131617
Theileria parva DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis ATP dependent DNA helicase Q5 Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum expressed protein Get druggable targets OG5_127917 All targets in OG5_127917
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II Get druggable targets OG5_131617 All targets in OG5_131617
Leishmania major hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Plasmodium knowlesi ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium yoelii NLI interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium vivax NLI interacting factor-like phosphatase, putative Get druggable targets OG5_127075 All targets in OG5_127075
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium parvum RecQ bloom helicase (RNA helicase+hrdc) Get druggable targets OG5_126644 All targets in OG5_126644
Treponema pallidum ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni jumonji domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Giardia lamblia Sgs1 DNA helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Schistosoma japonicum Bloom syndrome protein homolog, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Transcription factor JmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) ATP-dependent DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi jmjC domain containing protein Get druggable targets OG5_127917 All targets in OG5_127917
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Neospora caninum hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni blooms syndrome DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni DNA helicase recq5 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium berghei ATP-dependent DNA helicase Q1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126644 All targets in OG5_126644
Leishmania infantum ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127917 All targets in OG5_127917
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Onchocerca volvulus Get druggable targets OG5_131617 All targets in OG5_131617
Trichomonas vaginalis DNA helicase recq, putative Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni DNA helicase recq1 Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania infantum hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica recQ family helicase, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum ADP-dependent DNA helicase RecQ Get druggable targets OG5_126644 All targets in OG5_126644
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium yoelii ATP-dependent DNA helicase recQ-related Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Brugia malayi Pip kinase protein 2 Get druggable targets OG5_131617 All targets in OG5_131617
Plasmodium berghei ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis dullard protein, putative Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 Get druggable targets OG5_127075 All targets in OG5_127075
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum ATP-dependent DNA helicase Q1 Get druggable targets OG5_126644 All targets in OG5_126644
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica recQ family DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 Get druggable targets OG5_127075 All targets in OG5_127075
Cryptosporidium hominis DEAD/DEAH box helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis bloom syndrome protein Get druggable targets OG5_126644 All targets in OG5_126644
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K00889 1-phosphatidylinositol-4-phosphate 5-kinase [EC2.7.1.68], putative Get druggable targets OG5_131617 All targets in OG5_131617
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans one of two closely related potential jumonji-like transcription factor genes similar to S. cerevisiae RPH1 (YER169W) damage-resp Get druggable targets OG5_127917 All targets in OG5_127917
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis DNA helicase recq1, putative Get druggable targets OG5_126644 All targets in OG5_126644
Candida albicans Plasma membrane Sodium Response 1 Get druggable targets OG5_127075 All targets in OG5_127075
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Leishmania mexicana ATP-dependent DEAD/H DNA helicase recQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II Get druggable targets OG5_127075 All targets in OG5_127075
Echinococcus granulosus CTD small phosphatase protein like Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 Get druggable targets OG5_131617 All targets in OG5_131617
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Plasmodium knowlesi ADP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi ATP-dependent DNA helicase, RecQ family protein Get druggable targets OG5_126644 All targets in OG5_126644
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03654 ATP-dependent DNA helicase RecQ, putative Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative Get druggable targets OG5_127075 All targets in OG5_127075
Leishmania braziliensis hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Candida albicans DNA helicase Get druggable targets OG5_126644 All targets in OG5_126644
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_127075 All targets in OG5_127075
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Brugia malayi Cell death protein 3 precursor caspase 6, apoptosis-related cysteine peptidase 293 aa 270 aa 34.4 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Trypanosoma brucei TFIIF-stimulated CTD phosphatase, putative CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 260 aa 263 aa 27.0 %
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha phosphatidylinositol-5-phosphate 4-kinase, type II, alpha 406 aa 341 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.01 0.1054 0.3292
Loa Loa (eye worm) hypothetical protein 0.019 0.2168 0.6771
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0047 0.0397 0.1241
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0359 0.0076
Trichomonas vaginalis DNA polymerase eta, putative 0.0047 0.0397 0.1014
Plasmodium falciparum ataxin-2 like protein, putative 0.019 0.2168 1
Echinococcus granulosus survival motor neuron protein 1 0.0274 0.3202 0.6635
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0359 0.1654
Echinococcus granulosus Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0016 0.002
Echinococcus multilocularis ornithine aminotransferase 0.0046 0.0395 0.0389
Trypanosoma brucei ISWI complex protein 0.0018 0.005 0.0229
Echinococcus granulosus chromobox protein 1 0.0084 0.0861 0.1775
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0162 0.1819 0.5681
Brugia malayi hypothetical protein 0.0123 0.1336 0.4173
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0359 0.0076
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0332 0.153
Entamoeba histolytica hypothetical protein 0.0078 0.0781 1
Trypanosoma cruzi metacaspase, putative 0.0032 0.0217 0.1003
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0359 0.0472
Mycobacterium tuberculosis Conserved protein 0.0043 0.0359 0.0076
Trypanosoma cruzi metacaspase, putative 0.0032 0.0217 0.1003
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0016 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0547
Loa Loa (eye worm) hypothetical protein 0.0047 0.0404 0.1262
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.072 0.2248
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.01 0.1057 0.3302
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0018 0.004 0.0034
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2248 0.4653
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0114 0.1225 0.1219
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0397 0.1029
Brugia malayi Calcitonin receptor-like protein seb-1 0.0162 0.1819 0.5681
Trypanosoma cruzi phosphatidylinositol (3,5) kinase, putative 0.0016 0.0016 0.0073
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0955 0.1969
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0453 0.0447
Loa Loa (eye worm) hypothetical protein 0.0051 0.0451 0.1407
Brugia malayi intermediate filament protein 0.0031 0.0207 0.0646
Loa Loa (eye worm) hypothetical protein 0.0053 0.0482 0.1506
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0006 0.0009
Echinococcus multilocularis GPCR, family 2 0.0051 0.0453 0.0447
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.01 0.1057 0.2182
Giardia lamblia DINP protein human, muc B family 0.0047 0.0397 0.9825
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0453 0.1416
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0217 0.0293
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0448 0.1147
Echinococcus granulosus phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0016 0.002
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0032 0.0217 0.0679
Leishmania major hypothetical protein, conserved 0.0043 0.0359 0.1654
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.0785 0.1617
Onchocerca volvulus 0.0196 0.2248 0.8072
Brugia malayi PHD-finger family protein 0.0015 0.0012 0.0037
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0359 0.0076
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 1
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0861 0.2689
Echinococcus multilocularis PHD finger protein rhinoceros 0.0035 0.0256 0.025
Treponema pallidum exodeoxyribonuclease (exoA) 0.0041 0.0332 0.2117
Brugia malayi jmjC domain containing protein 0.0115 0.1247 0.3893
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0217 0.1003
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0085 0.0877 0.4046
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0047 0.0397 0.1833
Echinococcus multilocularis caspase 0.0032 0.0217 0.0211
Brugia malayi ImpB/MucB/SamB family protein 0.0077 0.0778 0.2428
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0234 0.059
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0073
Onchocerca volvulus Alhambra homolog 0.0035 0.0256 0.0327
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0054 0.0493 0.2273
Loa Loa (eye worm) hypothetical protein 0.0057 0.0531 0.1658
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0359 0.0076
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0861 0.2218
Brugia malayi CHD4 protein 0.0018 0.004 0.0125
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0217 0.1003
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0332 0.0844
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0397 0.1833
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1924 0.3981
Trypanosoma brucei metacaspase MCA2 0.0032 0.0217 0.1003
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0359 0.0914
Brugia malayi beta-lactamase family protein 0.0043 0.0359 0.112
Trypanosoma brucei DNA polymerase eta, putative 0.0077 0.0778 0.3586
Brugia malayi ImpB/MucB/SamB family protein 0.0047 0.0397 0.1241
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0073
Schistosoma mansoni hypothetical protein 0.0615 0.7419 1
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0058
Echinococcus granulosus bloom syndrome protein 0.0029 0.018 0.0359
Mycobacterium tuberculosis Probable acetylornithine aminotransferase ArgD 0.0046 0.0395 0.0181
Trypanosoma brucei metacaspase 5, putative 0.0032 0.0217 0.1003
Schistosoma mansoni lamin 0.0031 0.0207 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0451 0.0607
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0217 0.1003
Mycobacterium ulcerans acetylornithine aminotransferase 0.0046 0.0395 0.1024
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0016 0.0073
Trypanosoma brucei phosphatidylinositol (3,5) kinase, putative 0.0016 0.0016 0.0073
Echinococcus granulosus lamin dm0 0.0031 0.0207 0.0416
Echinococcus granulosus cpg binding protein 0.0032 0.0221 0.0445
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0041 0.0332 0.153
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0359 0.0929
Echinococcus multilocularis chromobox protein 1 0.0084 0.0861 0.0855
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0017 0.0034 0.0072
Giardia lamblia Phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0394
Leishmania major hypothetical protein, conserved 0.0015 0.0006 0.003
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 1
Leishmania major DNA polymerase eta, putative 0.0045 0.038 0.1754
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Brugia malayi F/Y-rich N-terminus family protein 0.0024 0.0113 0.0352
Schistosoma mansoni hypothetical protein 0.0018 0.005 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0359 0.0914
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0168
Leishmania major hypothetical protein, conserved 0.019 0.2168 1
Schistosoma mansoni zinc finger protein 0.0018 0.005 0.0067
Schistosoma mansoni ap endonuclease 0.0041 0.0332 0.0447
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0047 0.0397 0.0536
Echinococcus granulosus histone acetyltransferase KAT2B 0.0054 0.0493 0.101
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0207 0.0646
Trichomonas vaginalis DNA helicase recq, putative 0.0029 0.018 0.0449
Brugia malayi PHD-finger family protein 0.0036 0.0266 0.0831
Schistosoma mansoni zinc finger protein 0.003 0.0186 0.0251
Echinococcus multilocularis lysine specific demethylase 5A 0.0043 0.0348 0.0342
Echinococcus multilocularis phosphatidylinositol phosphate 5 kinase type III 0.0016 0.0016 0.001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0448 0.1074
Mycobacterium ulcerans beta-lactamase 0.0043 0.0359 0.0929
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0056 0.0513 0.0515
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0955 0.1287
Loa Loa (eye worm) hypothetical protein 0.0051 0.0453 0.1416
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0076 0.0144
Echinococcus granulosus lysine specific demethylase 5A 0.0047 0.0396 0.081
Schistosoma mansoni cpg binding protein 0.0032 0.0221 0.0298
Plasmodium vivax ataxin-2 like protein, putative 0.019 0.2168 1
Echinococcus granulosus GPCR family 2 0.0051 0.0453 0.0928
Schistosoma mansoni hypothetical protein 0.0035 0.0256 0.0346
Echinococcus granulosus zinc finger protein 0.003 0.0186 0.0374
Mycobacterium leprae PROBABLE GLUTAMATE-1-SEMIALDEHYDE 2,1-AMINOMUTASE HEML (GSA) (GLUTAMATE-1-SEMIALDEHYDE AMINOTRANSFERASE) (GSA-AT) 0.0046 0.0395 0.0572
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0041 0.0332 0.0325
Schistosoma mansoni phosphatidylinositol-4-phosphate-5-kinaseputativ e 0.0016 0.0016 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0234 0.059
Schistosoma mansoni cpg binding protein 0.0032 0.0221 0.0298
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0073
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0196 0.0904
Brugia malayi latrophilin 2 splice variant baaae 0.011 0.1187 0.3707
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0015 0.0006 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0029 0.0185 0.0853
Loa Loa (eye worm) hypothetical protein 0.0114 0.1225 0.3825
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0359 0.1654
Schistosoma mansoni hypothetical protein 0.0078 0.0781 0.1053
Trypanosoma brucei unspecified product 0.0047 0.0397 0.1833
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM 0.0046 0.0395 0.0572
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0046 0.0395 0.1024
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2248 0.3029
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0358 0.0729
Schistosoma mansoni apoptosis regulator bax 0.01 0.1057 0.1425
Schistosoma mansoni hypothetical protein 0.0205 0.2351 0.3168
Echinococcus multilocularis zinc finger protein 0.003 0.0186 0.018
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0172 0.0538
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0071 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Echinococcus multilocularis survival motor neuron protein 1 0.0274 0.3202 0.3198
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0404 0.1032
Mycobacterium ulcerans lipase LipD 0.0043 0.0359 0.0929
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0196 0.0264
Schistosoma mansoni hypothetical protein 0.01 0.1057 0.1425
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0327 0.386 1
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0397 0.1833
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0016 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0801
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Onchocerca volvulus 0.0037 0.0278 0.0412
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0359 0.1654
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0032 0.0217 0.0211
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.002 0.0063 0.0293
Brugia malayi Bromodomain containing protein 0.0096 0.1014 0.3166
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0359 0.0483
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0006 0.003
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0085 0.0877 0.1808
Trichomonas vaginalis DNA helicase recq1, putative 0.0029 0.018 0.0449
Leishmania major phosphatidylinositol (3,5) kinase, putative 0.0016 0.0016 0.0073
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0877 0.4046
Entamoeba histolytica recQ family helicase, putative 0.0015 0.0013 0.008
Brugia malayi SET domain containing protein 0.0015 0.0013 0.0039
Echinococcus multilocularis Phosphatidylinositol 4 phosphate 5 kinase type 1 0.0016 0.0016 0.001
Echinococcus granulosus Aminotransferase class III 0.0046 0.0395 0.0808
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.2389 0.7462
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0448 0.1147
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.0217 0.0293
Toxoplasma gondii LsmAD domain-containing protein 0.019 0.2168 1
Schistosoma mansoni hypothetical protein 0.011 0.1187 0.16
Schistosoma mansoni hypothetical protein 0.01 0.1057 0.1425
Mycobacterium tuberculosis Probable aminotransferase 0.0327 0.386 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0115 0.1247 0.2575
Echinococcus multilocularis histone acetyltransferase MYST2 0.0114 0.1225 0.1219
Schistosoma mansoni hypothetical protein 0.0051 0.0453 0.0611
Toxoplasma gondii hypothetical protein 0.0029 0.0185 0.0853
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0404 0.1865
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0358 0.0351
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0359 0.1654
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0404 0.0902
Loa Loa (eye worm) bromodomain containing protein 0.0026 0.0138 0.0431
Loa Loa (eye worm) hypothetical protein 0.0043 0.0359 0.112
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.01 0.1057 0.1052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0396 0.0534
Trypanosoma cruzi metacaspase 5, putative 0.0032 0.0217 0.1003
Echinococcus multilocularis dna polymerase kappa 0.0047 0.0397 0.0391
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0359 0.112
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0168
Echinococcus multilocularis lamin dm0 0.0031 0.0207 0.02
Trichomonas vaginalis DNA helicase recq, putative 0.0015 0.0013 0.0016
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0327 0.386 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0051 0.0451 0.0607
Echinococcus granulosus jumonji domain containing protein 0.0049 0.0427 0.0873
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0046 0.0395 0.1235
Brugia malayi Bromodomain containing protein 0.0051 0.0446 0.1392
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 0.4046
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0016 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0588 0.2714
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0029 0.0185 0.0853
Entamoeba histolytica phosphoinositide kinase, putative 0.0016 0.0016 0.0123
Brugia malayi exodeoxyribonuclease III family protein 0.0041 0.0332 0.1036
Loa Loa (eye worm) acetyltransferase 0.0178 0.202 0.6308
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0196 0.2248 0.3029
Trypanosoma brucei DNA polymerase IV, putative 0.0047 0.0397 0.1833
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0071 0.0168
Onchocerca volvulus 0.01 0.1054 0.343
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0679
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.01 0.1057 0.2182
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.058 0.0781
Trypanosoma cruzi ISWI complex protein 0.0018 0.005 0.0229
Mycobacterium tuberculosis Probable glutamate-1-semialdehyde 2,1-aminomutase HemL (GSA) (glutamate-1-semialdehyde aminotransferase) (GSA-at) 0.0046 0.0395 0.0181
Echinococcus granulosus geminin 0.0205 0.2351 0.4867
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0162 0.1819 0.5681
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0076 0.0069
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0114 0.1225 0.253
Schistosoma mansoni ap endonuclease 0.0041 0.0332 0.0447
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0256 0.1182
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0041 0.0332 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0219 0.1008
Brugia malayi Pre-SET motif family protein 0.0208 0.2389 0.7462
Loa Loa (eye worm) hypothetical protein 0.0014 0 0.0001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0054 0.0493 0.2273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0955 0.0949
Schistosoma mansoni hypothetical protein 0.0025 0.0129 0.0174
Schistosoma mansoni cpg binding protein 0.0028 0.0172 0.0232
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0327 0.386 1
Plasmodium falciparum phosphatidylinositol-4-phosphate 5-kinase 0.0016 0.0016 0.0073
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0015 0.0006 0.0009
Brugia malayi beta-lactamase 0.0043 0.0359 0.112
Loa Loa (eye worm) CHromoDomain protein family member 0.0018 0.004 0.0125
Giardia lamblia Hypothetical protein 0.0016 0.0016 0.0394
Brugia malayi Bloom's syndrome protein homolog 0.0029 0.018 0.0561
Brugia malayi Pre-SET motif family protein 0.003 0.0196 0.0612
Plasmodium falciparum ataxin-2 like protein, putative 0.019 0.2168 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0196 0.019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0168
Toxoplasma gondii ABC1 family protein 0.0043 0.0359 0.1654
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0041 0.0332 0.4198
Loa Loa (eye worm) mbt repeat family protein 0.01 0.1054 0.3292
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.0007 0.0002
Schistosoma mansoni hypothetical protein 0.0205 0.2351 0.3168
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.3255 0.8284
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0044 0.0366 0.0494
Trypanosoma cruzi phosphatidylinositol 4-phosphate 5-kinase alpha, putative 0.0016 0.0016 0.0073
Schistosoma mansoni DNA polymerase eta 0.0077 0.0778 0.1048
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0041 0.0332 0.153
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0196 0.2248 0.2243
Echinococcus multilocularis bloom syndrome protein 0.0029 0.018 0.0173
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0401 0.4783 0.9917
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0359 0.0076
Trypanosoma cruzi ISWI complex protein 0.0018 0.005 0.0229
Onchocerca volvulus 0.0056 0.0511 0.1316
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0359 0.0914
Brugia malayi Pip kinase protein 1 0.0016 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0013
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0041 0.0332 0.1036
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0219 0.1008
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0041 0.0332 0.0675
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0023
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like, putative 0.0016 0.0016 0.0073
Schistosoma mansoni hypothetical protein 0.01 0.1057 0.1425
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0058
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA 0.0327 0.386 1
Onchocerca volvulus 0.0031 0.0207 0.0134
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0178 0.0356
Mycobacterium ulcerans ornithine aminotransferase RocD1 and RocD2 0.0046 0.0395 0.1024
Mycobacterium tuberculosis Conserved protein 0.0043 0.0359 0.0076
Brugia malayi hypothetical protein 0.0078 0.0781 0.2439
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0547
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase type II beta, putative 0.0016 0.0016 0.0073
Toxoplasma gondii PHD-finger domain-containing protein 0.0035 0.0256 0.1182
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0073
Loa Loa (eye worm) hypothetical protein 0.0274 0.3202 1
Trypanosoma brucei metacaspase 0.0032 0.0217 0.1003
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0861 0.2218
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0453 0.1416
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0178 0.0171
Schistosoma mansoni hypothetical protein 0.0056 0.0511 0.0688
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0085 0.0877 0.4046
Echinococcus multilocularis caspase 8 0.0032 0.0217 0.0211
Trypanosoma brucei phosphatidylinositol phosphate kinase alpha 0.0016 0.0016 0.0073
Schistosoma mansoni jumonji/arid domain-containing protein 0.0047 0.0396 0.0534
Loa Loa (eye worm) hypothetical protein 0.0046 0.0394 0.123
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0018 0.004 0.0054
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0076 0.0102
Onchocerca volvulus 0.0044 0.0366 0.0754
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0015 0.0006 0.0158
Mycobacterium leprae Probable lipase LipE 0.0043 0.0359 0.0472
Schistosoma mansoni chromobox protein 0.0084 0.0861 0.1161
Loa Loa (eye worm) apoptosis regulator protein 0.01 0.1057 0.3302
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0955 0.1287
Echinococcus multilocularis polycomb protein SCMH1 0.01 0.1054 0.1048
Brugia malayi mbt repeat family protein 0.01 0.1054 0.3292
Trypanosoma cruzi hypothetical protein, conserved 0.0015 0.0006 0.003
Echinococcus multilocularis jumonji domain containing protein 0.0049 0.0427 0.0421
Trichomonas vaginalis bromodomain-containing protein, putative 0.0054 0.0493 0.1262
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0028 0.0087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0359 0.112
Echinococcus multilocularis Aminotransferase class III 0.0046 0.0395 0.0389
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0955 0.2981
Mycobacterium ulcerans DNA polymerase IV 0.0047 0.0397 0.1029
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0404 0.1032
Mycobacterium ulcerans hypothetical protein 0.0043 0.0359 0.0929
Echinococcus granulosus caspase 0.0032 0.0217 0.0438
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0781 0.1608
Loa Loa (eye worm) RecQ helicase 0.0029 0.018 0.0561
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0781 0.0775
Brugia malayi Cell death protein 3 precursor 0.0032 0.0217 0.0679
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0359 0.0483
Trichomonas vaginalis esterase, putative 0.0043 0.0359 0.0914
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.0785 0.0779
Echinococcus granulosus caspase 2 0.0032 0.0217 0.0438
Loa Loa (eye worm) hypothetical protein 0.0085 0.0877 0.2738
Loa Loa (eye worm) hypothetical protein 0.0077 0.0778 0.2428
Mycobacterium ulcerans 4-aminobutyrate aminotransferase 0.0046 0.0395 0.1024
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0025 0.0136 0.0627
Loa Loa (eye worm) FYVE zinc finger family protein 0.0016 0.0016 0.005
Echinococcus granulosus ornithine aminotransferase 0.0046 0.0395 0.0808
Brugia malayi hypothetical protein 0.019 0.2168 0.6771
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0207 0.0646
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0207 0.0646
Schistosoma mansoni jumonji domain containing protein 0.0092 0.0954 0.1285
Brugia malayi Heterochromatin protein 1 0.0084 0.0861 0.2689
Mycobacterium ulcerans L-lysine aminotransferase 0.0046 0.0395 0.1024
Mycobacterium tuberculosis Probable L-lysine-epsilon aminotransferase Lat (L-lysine aminotransferase) (lysine 6-aminotransferase) 0.0046 0.0395 0.0181
Loa Loa (eye worm) MBCTL1 0.0114 0.1225 0.3825
Onchocerca volvulus 0.0236 0.2743 1
Trypanosoma brucei Metacaspase-4 0.0032 0.0217 0.1003
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0051 0.0451 0.0445
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0018 0.004 0.007
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0047 0.0397 0.0186
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0114 0.1225 0.3825
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0547
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0028 0.0087
Echinococcus granulosus PHD finger protein rhinoceros 0.0035 0.0256 0.0519
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Leishmania major phosphatidylinositol-4-phosphate-5-kinase-likep ro tein 0.0016 0.0016 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0034 0.0072
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0015 0.0006 0.003
Loa Loa (eye worm) hypothetical protein 0.0015 0.0012 0.0037
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0032 0.0217 0.0438
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0178 0.202 0.2723
Echinococcus granulosus chromobox protein 1 0.0084 0.0861 0.1775
Loa Loa (eye worm) hypothetical protein 0.0015 0.0006 0.002
Onchocerca volvulus 0.0043 0.0359 0.0725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0955 0.0949
Loa Loa (eye worm) hypothetical protein 0.01 0.1057 0.3302
Mycobacterium tuberculosis Conserved protein 0.0043 0.0359 0.0076
Echinococcus granulosus SAM and MBT domain containing protein 0.01 0.1054 0.2175
Schistosoma mansoni lamin 0.0031 0.0207 0.0279
Onchocerca volvulus 0.0043 0.0359 0.0725
Trypanosoma cruzi PAB1-binding protein , putative 0.019 0.2168 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0046 0.0395 0.1824
Brugia malayi FYVE finger-containing phosphoinositide kinase, putative 0.0016 0.0016 0.005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0359 0.112
Echinococcus granulosus intermediate filament protein 0.0031 0.0207 0.0416
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Echinococcus multilocularis SAM and MBT domain containing protein 0.01 0.1054 0.1048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0207 0.0646
Loa Loa (eye worm) pip kinase 1 0.0016 0.0016 0.005
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0217 0.1003
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0085 0.0877 0.1884
Loa Loa (eye worm) hypothetical protein 0.006 0.0567 0.1772
Echinococcus multilocularis dna polymerase eta 0.0077 0.0778 0.0772
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0085 0.0874 0.0868
Schistosoma mansoni hypothetical protein 0.0051 0.0453 0.0611
Trypanosoma brucei phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0073
Trypanosoma cruzi DNA polymerase eta, putative 0.0045 0.038 0.1754
Mycobacterium ulcerans hypothetical protein 0.0327 0.386 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0047 0.0397 0.0391
Loa Loa (eye worm) hypothetical protein 0.0043 0.0359 0.112
Plasmodium falciparum metacaspase 1 0.0032 0.0217 0.1003
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0032 0.0217 0.0293
Schistosoma mansoni survival motor neuron protein 0.0056 0.0511 0.0688
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0955 0.1969
Brugia malayi acetyltransferase, GNAT family protein 0.0178 0.202 0.6308
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0046 0.0395 0.0533
Mycobacterium tuberculosis Probable ornithine aminotransferase (N-terminus part) RocD1 (ornithine--oxo-acid aminotransferase) 0.0046 0.0395 0.0181
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0175 0.035
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0046 0.0395 0.1169
Echinococcus granulosus peptidase Clp S14 family 0.0056 0.0513 0.1053
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0064 0.0086
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0016 0.0021
Onchocerca volvulus 0.0031 0.0207 0.0134
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0453 0.0447
Loa Loa (eye worm) hypothetical protein 0.0043 0.0359 0.112
Schistosoma mansoni hypothetical protein 0.0015 0.0004 0.0006
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0054 0.0493 0.2273
Entamoeba histolytica hypothetical protein 0.0078 0.0781 1
Echinococcus multilocularis caspase 2 0.0032 0.0217 0.0211
Trypanosoma cruzi DNA polymerase eta, putative 0.0077 0.0778 0.3586
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0035 0.0256 0.0346
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.0007 0.0001
Plasmodium vivax metacaspase 1, putative 0.0032 0.0217 0.1003
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.01 0.1057 0.1425
Trypanosoma brucei unspecified product 0.0032 0.0219 0.1008
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0015 0.0006 0.003
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0015 0.001 0.0004
Trypanosoma brucei PAB1-binding protein , putative 0.019 0.2168 1
Schistosoma mansoni bromodomain containing protein 0.0082 0.0839 0.1131
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0019 0.0061 0.028
Schistosoma mansoni hypothetical protein 0.0405 0.4823 0.6501
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0256 0.1182
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1625 0.5074
Brugia malayi jmjC domain containing protein 0.0047 0.0396 0.1238
Echinococcus multilocularis peptidase Clp (S14 family) 0.0056 0.0513 0.0507
Echinococcus granulosus dnaJ subfamily B 0.0405 0.4823 1
Echinococcus granulosus dna polymerase eta 0.0077 0.0778 0.1601
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0404 0.5138
Plasmodium vivax SET domain protein, putative 0.003 0.0196 0.0904
Trichomonas vaginalis ap endonuclease, putative 0.0041 0.0332 0.0844
Trypanosoma brucei unspecified product 0.0032 0.0219 0.1008
Schistosoma mansoni caspase-3 (C14 family) 0.0032 0.0217 0.0293
Trypanosoma cruzi metacaspase, putative 0.0032 0.0217 0.1003
Brugia malayi PHD-finger family protein 0.0035 0.0256 0.0801
Entamoeba histolytica deoxycytidyl transferase, putative 0.0047 0.0397 0.5047
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0016 0.0016 0.0021
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0015 0.0006 0.003
Echinococcus multilocularis chromobox protein 1 0.0084 0.0861 0.0855
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2743 0.7101
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0359 0.0731
Loa Loa (eye worm) hypothetical protein 0.0043 0.0359 0.112
Echinococcus multilocularis cpg binding protein 0.0032 0.0221 0.0215
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0955 0.2981
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0547
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0085 0.0877 0.0871
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0359 0.0076
Schistosoma mansoni intermediate filament proteins 0.0031 0.0207 0.0279
Schistosoma mansoni hypothetical protein 0.0085 0.0874 0.1178
Plasmodium falciparum metacaspase-like protein 0.0032 0.0217 0.1003
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0781 0.1053
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 0.2273
Loa Loa (eye worm) hypothetical protein 0.0085 0.0877 0.274
Loa Loa (eye worm) hypothetical protein 0.0032 0.0217 0.0679
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 0.2273
Leishmania major hypothetical protein, conserved 0.0018 0.005 0.0229
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0054 0.0493 0.1262
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0453 0.1416
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0359 0.0914
Schistosoma mansoni hypothetical protein 0.0051 0.0453 0.0611
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Trypanosoma brucei DNA polymerase kappa, putative 0.0032 0.0219 0.1008
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0047 0.0397 0.0812
Schistosoma mansoni peptidase Clp (S14 family) 0.0085 0.0877 0.1183
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0041 0.0332 0.153
Schistosoma mansoni chromobox protein 0.0084 0.0861 0.1161
Leishmania major metacaspase, putative 0.0032 0.0217 0.1003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0359 0.112
Entamoeba histolytica hypothetical protein 0.0078 0.0781 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.01 0.1054 0.343
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0016 0.0025
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0015 0.001 0.0008
Brugia malayi chromobox protein homolog 3 0.0047 0.0404 0.1262
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.038 0.1754
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0032 0.0217 0.1003
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0401 0.4783 0.4779
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0168
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0076 0.0102
Brugia malayi hypothetical protein 0.0274 0.3202 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0051 0.0451 0.0922
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0056 0.0513 0.0515
Trypanosoma cruzi PAB1-binding protein , putative 0.019 0.2168 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0041 0.0332 0.153
Schistosoma mansoni hypothetical protein 0.0051 0.0453 0.0611
Echinococcus granulosus dna polymerase kappa 0.0047 0.0397 0.0812
Loa Loa (eye worm) hypothetical protein 0.011 0.1187 0.3707
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Loa Loa (eye worm) hypothetical protein 0.0037 0.0278 0.0869
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0056 0.0511 0.1595
Plasmodium vivax hypothetical protein, conserved 0.0016 0.0016 0.0073
Toxoplasma gondii exonuclease III APE 0.0041 0.0332 0.153
Echinococcus multilocularis geminin 0.0205 0.2351 0.2346
Schistosoma mansoni terminal deoxycytidyl transferase 0.0047 0.0397 0.0536
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0041 0.0332 0.153
Echinococcus granulosus caspase 8 0.0032 0.0217 0.0438
Entamoeba histolytica hypothetical protein 0.0078 0.0781 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0071 0.0168
Trypanosoma brucei DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Echinococcus granulosus polycomb protein SCMH1 0.01 0.1054 0.2175
Plasmodium falciparum phd finger protein, putative 0.0035 0.0256 0.1182
Loa Loa (eye worm) hypothetical protein 0.0162 0.1819 0.5681
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0178 0.202 0.2015
Echinococcus multilocularis peregrin 0.0042 0.0345 0.0339
Echinococcus granulosus histone acetyltransferase MYST2 0.0114 0.1225 0.253
Brugia malayi Pip kinase protein 2 0.0196 0.2248 0.7019
Echinococcus multilocularis musashi 0.0031 0.0207 0.02
Plasmodium falciparum ornithine aminotransferase 0.0046 0.0395 0.1824
Mycobacterium leprae Probable Acetylornithine aminotransferase ArgD 0.0046 0.0395 0.0572
Brugia malayi Bromodomain containing protein 0.0042 0.0345 0.1077
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0085 0.0877 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0178 0.024
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0032 0.0217 0.0547
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0359 0.0914
Trichomonas vaginalis phosphatidylinositol-4-phosphate 5-kinase type II, putative 0.0016 0.0016 0.0025
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0453 0.0928
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0129 0.0403
Onchocerca volvulus 0.0043 0.0359 0.0725
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0453 0.0928
Leishmania major phosphatidylinositol-4-phosphate 5-kinase-like protein 0.0016 0.0016 0.0073
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0955 0.1287
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0017 0.0028 0.0057
Plasmodium vivax phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0073
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0015 0.0006 0.003
Trypanosoma brucei metacaspase MCA3 0.0032 0.0217 0.1003
Echinococcus multilocularis lamin 0.0031 0.0207 0.02
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0047 0.0397 0.1014
Echinococcus granulosus lamin 0.0031 0.0207 0.0416
Loa Loa (eye worm) hypothetical protein 0.0196 0.2248 0.7019
Loa Loa (eye worm) beta-lactamase 0.0043 0.0359 0.112
Trypanosoma cruzi DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Loa Loa (eye worm) hypothetical protein 0.0031 0.02 0.0624
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0359 0.0929
Echinococcus granulosus peregrin 0.0042 0.0345 0.0702
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0013 0.0058
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0359 0.0352
Leishmania major DNA polymerase kappa, putative 0.0047 0.0397 0.1833
Schistosoma mansoni blooms syndrome DNA helicase 0.0023 0.0104 0.014
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.0217 0.0175
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0041 0.0332 0.82
Entamoeba histolytica phosphatidylinositol-4-phosphate 5-kinase, putative 0.0016 0.0016 0.0123
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0056 0.0513 0.0894
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0547
Brugia malayi CXXC zinc finger family protein 0.0028 0.0172 0.0538
Loa Loa (eye worm) jmjC domain-containing protein 0.0047 0.0396 0.1238
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0359 0.0076
Schistosoma mansoni sex comb on midleg homolog 0.01 0.1054 0.1421
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0115 0.1247 0.1241
Loa Loa (eye worm) pip kinase 2 0.0196 0.2248 0.7019
Loa Loa (eye worm) PHD-finger family protein 0.0035 0.0256 0.0801
Plasmodium vivax ornithine aminotransferase, putative 0.0046 0.0395 0.1824
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.0397 0.0186
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0404 1
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type I 0.0016 0.0016 0.0021
Echinococcus multilocularis ornithine aminotransferase 0.0046 0.0395 0.0389
Giardia lamblia PHD finger protein 15 0.0035 0.0256 0.6339
Leishmania major DNA polymerase eta, putative 0.0077 0.0778 0.3586
Brugia malayi Probable ClpP-like protease 0.0085 0.0877 0.274
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.01 0.1054 0.1421
Brugia malayi mbt repeat family protein 0.01 0.1054 0.3292
Trypanosoma cruzi metacaspase, putative 0.0032 0.0217 0.1003
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.4823 0.482
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.01 0.1057 0.1052
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0217 0.0547
Schistosoma mansoni myelin transcription factor 1 myt1 0.0114 0.1225 0.1651
Toxoplasma gondii phosphatidylinositol-4-phosphate 5-Kinase 0.0016 0.0016 0.0073
Brugia malayi beta-lactamase family protein 0.0043 0.0359 0.112
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0085 0.0874 0.1801
Schistosoma mansoni sex comb on midleg homolog 0.01 0.1054 0.1421
Mycobacterium ulcerans glutamate-1-semialdehyde aminotransferase 0.0046 0.0395 0.1024
Loa Loa (eye worm) FYVE finger-containing phosphoinositide kinase 0.0016 0.0016 0.005

Activities

Activity type Activity value Assay description Source Reference
AC50 (binding) 1.55 uM PubChem BioAssay. VEID(2) R110 Enzymatic Primary HTS to identify Inhibitors of Caspase 6 Measured in Biochemical System Using Plate Reader - 7052-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (functional) 70 uM PubChem BioAssay. Caspase 7 Counterscreen for Selectivity Fluorescent Measured in Cell-Based System Using Plate Reader - 7052-04_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
AC50 (binding) 70 uM PubChem BioAssay. Caspase 8 Counterscreen for Selectivity Fluorescent Measured in Biochemical System Using Plate Reader - 7052-05_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (functional) = 3.967 uM PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493091, AID493120] ChEMBL. No reference
IC50 (binding) = 8.772 um PUBCHEM_BIOASSAY: Fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of myeloid cell leukemia sequence 1 (MCL1) interactions with BIM-BH3 peptide. (Class of assay: confirmatory) [Related pubchem assays: 2090 (Summary AID.), 2057 (Screening assay (MCL1 inhibitors).), 2168 (Screening assay (MCL1 inhibitors).)] ChEMBL. No reference
IC50 (functional) 63.294 uM PubChem BioAssay. An HIV-1 Tat-TAR Fluorescence Polarization (FP) Counter Screen to evaluate Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) > 108.803 um PUBCHEM_BIOASSAY: Counterscreen for inhibitors of MCL1: fluorescence polarization-based biochemical high throughput dose response assay for inhibitors of BCL2-related protein, long isoform (BCLXL). (Class of assay: confirmatory) [Related pubchem assays: 2129 (Screening assay (BCLXL inhibitors).), 2057 (Screening assay (MCL-1 inhibitors).), 2144 (Summary AID.), 2166 (Screening assay (BCLXL inhibitors).)] ChEMBL. No reference
Potency (functional) 0.092 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.8888 uM PubChem BioAssay. qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 2.2387 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 3.7686 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 6.3096 uM PubChem BioAssay. qHTS for Inhibitors of PI5P4K: Confirmation in Primary Assay. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference
Potency (functional) 9.4662 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 9.5283 uM PubChem BioAssay. qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (functional) 17.7828 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 21.3313 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of T. brucei phosphofructokinase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488768, AID492961] ChEMBL. No reference
Potency (functional) 25.1189 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 28.1838 uM PUBCHEM_BIOASSAY: qHTS Assay to Find Inhibitors of Phosphoglycerate Kinase. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.9349 uM PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Kappa. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588638] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 63.0957 uM PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488813] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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