Detailed information for compound 1390655

Basic information

Technical information
  • TDR Targets ID: 1390655
  • Name: N-[1-(1-adamantyl)ethyl]-2-pyrrolidin-1-ylace tamide hydrochloride
  • MW: 326.905 | Formula: C18H31ClN2O
  • H donors: 1 H acceptors: 1 LogP: 4.24 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(NC(C12CC3CC(C2)CC(C1)C3)C)CN1CCCC1.Cl
  • InChi: 1S/C18H30N2O.ClH/c1-13(19-17(21)12-20-4-2-3-5-20)18-9-14-6-15(10-18)8-16(7-14)11-18;/h13-16H,2-12H2,1H3,(H,19,21);1H
  • InChiKey: FAMZESDZYDTCRV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[1-(1-adamantyl)ethyl]-2-pyrrolidin-1-yl-acetamide hydrochloride
  • N-[1-(1-adamantyl)ethyl]-2-1-pyrrolidinylacetamide hydrochloride
  • N-[1-(1-adamantyl)ethyl]-2-pyrrolidin-1-yl-ethanamide hydrochloride
  • MLS000538365
  • N-[1-(1-adamantyl)ethyl]-2-(1-pyrrolidinyl)acetamide hydrochloride
  • SMR000144402

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL No references
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0138 0.0138
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0272 0.0271
Plasmodium falciparum serine repeat antigen 5 0.0266 0.0827 0.2367
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.1061 0.3456 0.3455
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0032 0.0054 0.0219
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0049 0.0049
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0053 0.0119
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0049 0.0048
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0201
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0049 0.0048
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0024 0.047
Echinococcus multilocularis cathepsin L cysteine protease 0.1061 0.3456 0.3455
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0147
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.001
Echinococcus multilocularis zinc finger protein 0.002 0.0015 0.0014
Leishmania major protein kinase, putative 0.0032 0.0053 0.0146
Brugia malayi MH2 domain containing protein 0.0066 0.0166 0.0165
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0103 0.0289 0.0288
Echinococcus granulosus General substrate transporter 0.0089 0.0241 0.024
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0032 0.0054 0.0219
Toxoplasma gondii protein kinase, putative 0.0292 0.0912 0.247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0049 0.0048
Schistosoma mansoni cathepsin B (C01 family) 0.0266 0.0827 0.0827
Toxoplasma gondii cathepsin CPC2 0.0266 0.0827 0.2236
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0032 0.0054 0.0483
Toxoplasma gondii preprocathepsin c precursor, putative 0.0266 0.0827 0.2236
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.005 0.005
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0053 0.0122
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0032 0.0054 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Loa Loa (eye worm) CYP4Cod1 0.0043 0.0089 0.0088
Leishmania major cytochrome p450-like protein 0.0043 0.0089 0.0242
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0564 0.0563
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0074 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0049 0.0048
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0032 0.0054 0.0054
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0204 0.0204
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0186 0.0564 0.0563
Mycobacterium tuberculosis Probable reductase 0.0084 0.0225 0.2494
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0068 0.0067
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0092 0.0091
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0016 0.0001 0.0001
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0225 0.0693 0.0692
Echinococcus multilocularis cathepsin L cysteine protease 0.1061 0.3456 0.3455
Echinococcus multilocularis voltage dependent calcium channel 0.0186 0.0564 0.0563
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0049 0.0048
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.005 0.0049
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0024 0.0023
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0032 0.0054 0.0483
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0074 0.0073
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Toxoplasma gondii cathepsin B 0.1124 0.3664 1
Onchocerca volvulus 0.1061 0.3456 1
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0173 0.0172
Brugia malayi cathepsin L-like precursor 0.0738 0.239 0.2389
Giardia lamblia Hypothetical protein 0.0266 0.0827 0.2205
Plasmodium falciparum serine repeat antigen 8 0.0266 0.0827 0.2367
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0074 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0049 0.0048
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0032 0.0054 0.0219
Onchocerca volvulus 0.1061 0.3456 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0092 0.0927
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0139 0.0409 0.0408
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.007 0.0069
Brugia malayi Cytochrome P450 family protein 0.0088 0.024 0.0239
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0024 0.5
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0327 0.0327
Echinococcus granulosus geminin 0.0205 0.0625 0.0624
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0289 0.0752
Brugia malayi Cytochrome P450 family protein 0.0043 0.0089 0.0088
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0272 0.0271
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0192 0.0192
Giardia lamblia Cathepsin L-like protease 0.0266 0.0827 0.2205
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0256 1
Brugia malayi Sugar transporter family protein 0.0103 0.0289 0.0288
Schistosoma mansoni kinase 0.0051 0.0116 0.0116
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0049 0.0049
Brugia malayi cathepsin F-like cysteine proteinase 0.0322 0.1014 0.1013
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0092 0.0498
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Onchocerca volvulus 0.0043 0.0092 0.0233
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0024 0.0024
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Plasmodium falciparum protein kinase 6 0.0438 0.1396 0.402
Brugia malayi cathepsin L precursor 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0154
Plasmodium vivax vivapain-3 0.0588 0.1893 0.5461
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0053 0.0122
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0588 0.1893 0.1893
Entamoeba histolytica protein kinase, putative 0.0032 0.0053 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Schistosoma mansoni hypothetical protein 0.0028 0.0042 0.0042
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0063 0.0155 0.0154
Echinococcus granulosus cathepsin l1 0.0738 0.239 0.2389
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0032 0.0054 0.0219
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0322 0.1014 0.1013
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0049 0.0049
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0131 0.013
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Toxoplasma gondii cathepsin CPL 0.1061 0.3456 0.9431
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0266 0.0827 0.2367
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1061 0.3456 0.3455
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0092
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0048 0.0107 0.0106
Onchocerca volvulus 0.0031 0.0049 0.0109
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0186 0.0564 0.0563
Echinococcus granulosus cysteine protease 0.0588 0.1893 0.1892
Leishmania major trypanothione reductase 0.0037 0.007 0.019
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Plasmodium falciparum glutathione reductase 0.0037 0.007 0.0169
Plasmodium falciparum serine repeat antigen 3 0.0266 0.0827 0.2367
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0173 0.0172
Trypanosoma cruzi hexose transporter, putative 0.0017 0.0006 0.0006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0092 0.0092
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0115 0.0114
Schistosoma mansoni cytochrome P450 0.0032 0.0054 0.0054
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Brugia malayi cytochrome P450 0.0032 0.0054 0.0053
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0827 0.2367
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.0054 0.0146
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Trypanosoma cruzi cruzipain precursor, putative 0.0322 0.1014 0.1014
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0173 0.0433
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0186 0.0564 0.0563
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0032 0.0054 0.0219
Loa Loa (eye worm) hypothetical protein 0.0031 0.005 0.0049
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.001
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0032 0.0054 0.0483
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0049 0.0048
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0049 0.0048
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Brugia malayi Inositol-1 0.0038 0.0074 0.0073
Echinococcus multilocularis cathepsin L 0.0266 0.0827 0.0826
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0042 0.0041
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Schistosoma mansoni lipoxygenase 0.008 0.0213 0.0213
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0042 0.0088
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Loa Loa (eye worm) hypothetical protein 0.3039 1 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0042 0.0041
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0053 0.0052
Brugia malayi glutathione reductase 0.0037 0.007 0.0069
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0049 0.0048
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0078 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0068 0.0068
Echinococcus granulosus cathepsin L 0.0588 0.1893 0.1892
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Onchocerca volvulus 0.0043 0.0092 0.0233
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0032 0.0054 0.0219
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0067 0.0157
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0092 0.0091
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0024 0.0037
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0053 0.0122
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0011 0.001
Loa Loa (eye worm) calcium channel 0.0186 0.0564 0.0563
Leishmania major glucose transporter, lmgt3 0.0032 0.0054 0.0146
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0266 0.0827 0.2367
Brugia malayi glutaminase DH11.1 0.0434 0.1382 0.1382
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Schistosoma mansoni hypothetical protein 0.0032 0.0054 0.0054
Echinococcus granulosus peregrin 0.0031 0.005 0.0049
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0092 0.0091
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.005 0.0076
Schistosoma mansoni hypothetical protein 0.0205 0.0625 0.0625
Plasmodium falciparum thioredoxin reductase 0.0037 0.007 0.0169
Plasmodium vivax unspecified product 0.0266 0.0827 0.2367
Brugia malayi cathepsin L-like cysteine proteinase 0.0266 0.0827 0.0826
Schistosoma mansoni voltage-gated cation channel 0.0186 0.0564 0.0564
Schistosoma mansoni inositol monophosphatase 0.0038 0.0074 0.0074
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.007 0.0069
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Loa Loa (eye worm) glutathione reductase 0.0037 0.007 0.0069
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.005 0.0049
Giardia lamblia Hypothetical protein 0.0266 0.0827 0.2205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Echinococcus multilocularis sodium channel protein 0.0048 0.0107 0.0106
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0032 0.0054 0.0219
Echinococcus granulosus RUN 0.0019 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Brugia malayi Thioredoxin reductase 0.0037 0.007 0.0069
Schistosoma mansoni lipoxygenase 0.0115 0.0327 0.0327
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0564 0.0563
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0055 0.0131 0.013
Brugia malayi Bromodomain containing protein 0.0077 0.0203 0.0203
Echinococcus multilocularis RUN 0.0019 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0044 0.0093 0.0092
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0049 0.0048
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0827 0.0826
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0074 0.0175
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Brugia malayi Papain family cysteine protease containing protein 0.1061 0.3456 0.3455
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0049 0.0049
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0166 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0054 0.0107
Brugia malayi hypothetical protein 0.0019 0.0011 0.001
Trypanosoma cruzi cruzipain precursor, putative 0.1061 0.3456 0.3456
Loa Loa (eye worm) transcription factor SMAD2 0.0066 0.0166 0.0165
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0054 0.0107
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0053 0.0119
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0049 0.0048
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0061 0.1968
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0092 0.0211
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0266 0.0827 0.0827
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Plasmodium vivax vivapain-2 0.1061 0.3456 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0139 0.0409 0.0408
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.3039 1 1
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0266 0.0827 0.2367
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0147
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.0061 0.0061
Onchocerca volvulus 0.1061 0.3456 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0272 0.0721
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0067 0.0162
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.019 0.052
Schistosoma mansoni inositol monophosphatase 0.0038 0.0074 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0032 0.0054 0.0219
Entamoeba histolytica cysteine proteinase 1, putative 0.0588 0.1893 0.5445
Echinococcus multilocularis General substrate transporter 0.0089 0.0241 0.024
Loa Loa (eye worm) hypothetical protein 0.004 0.0079 0.0078
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0049 0.0109
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3039 1 1
Giardia lamblia Encystation-specific protease 0.0266 0.0827 0.2205
Plasmodium vivax vivapain-1 0.0588 0.1893 0.5461
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Loa Loa (eye worm) ctsf protein 0.1061 0.3456 0.3455
Schistosoma mansoni hypothetical protein 0.0103 0.0289 0.0289
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.005 0.1544
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0032 0.0054 0.0483
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0061 0.0562
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0011 0.001
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Plasmodium falciparum serine repeat antigen 2 0.0266 0.0827 0.2367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0738 0.239 0.6509
Loa Loa (eye worm) hypothetical protein 0.0028 0.0042 0.0041
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0053 0.0119
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) glutaminase 0.0434 0.1382 0.1382
Trypanosoma cruzi cysteine peptidase, putative 0.0322 0.1014 0.1014
Trichomonas vaginalis set domain proteins, putative 0.0474 0.1517 0.4117
Schistosoma mansoni hypothetical protein 0.0205 0.0625 0.0625
Loa Loa (eye worm) hypothetical protein 0.0186 0.0564 0.0563
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0053 0.0122
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Plasmodium falciparum cysteine proteinase falcipain 1 0.0588 0.1893 0.5461
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0067 0.0183
Plasmodium falciparum serine repeat antigen 9 0.0266 0.0827 0.2367
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Toxoplasma gondii thioredoxin reductase 0.0037 0.007 0.0164
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0032 0.0054 0.0219
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0255 0.0254
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.005 0.0049
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0089 0.0088
Echinococcus multilocularis cathepsin b 0.3039 1 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0109 0.0108
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0092 0.0927
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Loa Loa (eye worm) hypothetical protein 0.0051 0.0115 0.0114
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0053 0.0052
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0032 0.0054 0.0219
Brugia malayi Cathepsin L-like cysteine proteinase 0.0738 0.239 0.2389
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0055 0.0131 0.0131
Schistosoma mansoni loxhd1 0.0019 0.0011 0.0011
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0049 0.0048
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0074 0.0162
Echinococcus granulosus voltage dependent calcium channel 0.0186 0.0564 0.0563
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0266 0.0827 0.2367
Entamoeba histolytica cysteine proteinase, putative 0.1061 0.3456 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0092 0.0927
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0266 0.0827 0.2225
Brugia malayi hypothetical protein 0.0063 0.0155 0.0154
Loa Loa (eye worm) hypothetical protein 0.0026 0.0035 0.0034
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0049 0.0049
Loa Loa (eye worm) glutaminase 2 0.0434 0.1382 0.1382
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Plasmodium falciparum serine repeat antigen 4 0.0266 0.0827 0.2367
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.019 0.0494
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0266 0.0827 0.2367
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.003
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0024 0.0023
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Plasmodium vivax vivapain-2 0.1061 0.3456 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Mycobacterium ulcerans glutaminase 0.0434 0.1382 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1124 0.3664 0.3664
Leishmania major glucose transporter, lmgt1 0.0032 0.0054 0.0146
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0032 0.0054 0.0219
Plasmodium vivax unspecified product 0.0588 0.1893 0.5461
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.007 0.0668
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0032 0.0054 0.0219
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0092 0.0092
Schistosoma mansoni cathepsin F (C01 family) 0.0738 0.239 0.239
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0067 0.0162
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0049 0.0048
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0053 0.0052
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0115 0.0114
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0564 0.0563
Echinococcus multilocularis cysteine protease 0.1061 0.3456 0.3455
Brugia malayi PHD-finger family protein 0.0028 0.0042 0.0041
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0266 0.0827 0.2367
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0049 0.0048
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0092 0.0498
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.007 0.0169
Plasmodium falciparum serine repeat antigen 6 0.0266 0.0827 0.2367
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3039 1 1
Echinococcus multilocularis geminin 0.0205 0.0625 0.0624
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0266 0.0827 0.2367
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0067 0.0067
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.3039 1 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0077 0.0204 0.0203
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0032 0.0054 0.0483
Plasmodium vivax CDK-related protein kinase 6, putative 0.0438 0.1396 0.402
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0011 0.001
Brugia malayi hypothetical protein 0.0019 0.0011 0.001
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0032 0.0054 0.0483
Loa Loa (eye worm) hypothetical protein 0.0042 0.0087 0.0086
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0827 0.0827
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0032 0.0054 0.0483
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Leishmania major cytochrome p450-like protein 0.0032 0.0054 0.0147
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0115 0.0114
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0272 0.0272
Trypanosoma brucei glucose transporter 2A 0.0032 0.0054 0.0146
Trypanosoma cruzi cysteine proteinase, putative 0.0588 0.1893 0.1893
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0186 0.0564 0.0564
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0024 0.0039
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Entamoeba histolytica cysteine proteinase 2 0.0588 0.1893 0.5445
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0074
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0827 0.2225
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0032 0.0054 0.0483
Echinococcus granulosus cathepsin L 0.0266 0.0827 0.0826
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0827 0.2339
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0225 0.2494
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0032 0.0054 0.0483
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Brugia malayi Cathepsin L-like precursor 0.0738 0.239 0.2389
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Schistosoma mansoni protein kinase 0.0032 0.0053 0.0053
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0173 0.0172
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0068 0.0067
Plasmodium falciparum phd finger protein, putative 0.0028 0.0042 0.0088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0131 0.013
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1124 0.3664 1
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0049 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Loa Loa (eye worm) inositol-1 0.0038 0.0074 0.0073
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0142 0.0141
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0186 0.0564 0.0563
Toxoplasma gondii ABC1 family protein 0.0043 0.0092 0.0224
Onchocerca volvulus Cathepsin L homolog 0.1061 0.3456 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0266 0.0827 0.2367
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0167 0.05 0.1418
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0827 0.2367
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0092 0.0927
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0049 0.0049
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0053 0.0106
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0065
Brugia malayi Cathepsin L-like precursor 0.0322 0.1014 0.1013
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) fibroinase 0.1061 0.3456 0.3455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0032 0.0054 0.0219
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0032 0.0054 0.0483
Schistosoma mansoni cathepsin F (C01 family) 0.1061 0.3456 0.3456
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Brugia malayi Pre-SET motif family protein 0.006 0.0146 0.0145
Brugia malayi cathepsin F-like cysteine proteinase 0.0266 0.0827 0.0826
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0979 0.0979
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0042 0.0041
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0827 0.0827
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.1772
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0588 0.1893 0.5166
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0979 0.0979
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Onchocerca volvulus 0.1061 0.3456 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0225 0.2494
Loa Loa (eye worm) cytochrome P450 family protein 0.0088 0.024 0.0239
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0049 0.0048
Onchocerca volvulus Cathepsin L homolog 0.1061 0.3456 1
Plasmodium vivax hexose transporter 0.0103 0.0289 0.0806
Trypanosoma cruzi major cysteine proteinase, putative 0.0266 0.0827 0.0827
Giardia lamblia PHD finger protein 15 0.0028 0.0042 0.0049
Mycobacterium ulcerans beta-lactamase 0.0043 0.0092 0.0498
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0053 0.0146
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0006
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Mycobacterium ulcerans lipase LipD 0.0043 0.0092 0.0498
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Loa Loa (eye worm) hypothetical protein 0.0023 0.0024 0.0023
Toxoplasma gondii facilitative glucose transporter GT1 0.0103 0.0289 0.0764
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0049 0.0109
Trichomonas vaginalis esterase, putative 0.0043 0.0092 0.0211
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0089 0.0089
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0272 0.0741
Brugia malayi beta-lactamase 0.0043 0.0092 0.0091
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.005 0.0072
Brugia malayi Cytochrome P450 family protein 0.0032 0.0054 0.0053
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0625 0.1672
Echinococcus multilocularis cathepsin b 0.3039 1 1
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0032 0.0054 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0139 0.0409 0.0408
Echinococcus multilocularis peregrin 0.0031 0.005 0.0049
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0167 0.05 0.1341
Schistosoma mansoni cathepsin C 0.0266 0.0827 0.0827
Leishmania major glucose transporter, lmgt2 0.0032 0.0054 0.0146
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.019 0.019
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0024 0.0023
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0327 0.0327
Onchocerca volvulus Cathepsin L homolog 0.0266 0.0827 0.2367
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0272 0.0272
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0272 0.0271
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0071 0.007
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Schistosoma mansoni glucose transport protein 0.0103 0.0289 0.0289
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0256 0.2856
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0054 0.0107
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0092 0.0927
Trichomonas vaginalis glucose transporter, putative 0.0032 0.0054 0.0107
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0255 0.0254
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0024 0.0024
Mycobacterium leprae putative cytochrome p450 0.0032 0.0054 0.169
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0032 0.0054 0.0483
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0071 0.007
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0049 0.0048
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0055 0.0131 0.013
Plasmodium vivax unspecified product 0.0322 0.1014 0.291
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0049 0.0109
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0032 0.0054 0.0147
Brugia malayi steroid hormone receptor 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0049 0.0048
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0738 0.239 0.239
Entamoeba histolytica cysteine proteinase, putative 0.1061 0.3456 1
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0049 0.0049
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.005 0.0097
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0186 0.0564 0.0563
Schistosoma mansoni glutaminase 0.0434 0.1382 0.1382
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0049 0.0049
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.019 0.019
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0111 0.0265
Loa Loa (eye worm) hypothetical protein 0.0077 0.0204 0.0203
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0078 0.0078
Trypanosoma brucei polo-like protein kinase 0.0098 0.0272 0.0741
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Echinococcus granulosus voltage dependent calcium channel 0.0026 0.0035 0.0034
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0092 0.0233
Echinococcus multilocularis 0.0032 0.0054 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0266 0.0827 0.2225
Onchocerca volvulus Cathepsin F homolog 0.1061 0.3456 1
Trypanosoma cruzi hexose transporter, putative 0.0032 0.0054 0.0054
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Schistosoma mansoni bromodomain containing protein 0.0065 0.0163 0.0163
Schistosoma mansoni cathepsin s 0.0322 0.1014 0.1014
Echinococcus multilocularis cysteine protease 0.1061 0.3456 0.3455
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0078 0.0077
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0266 0.0827 0.2225
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.005 0.005
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0146 0.0146
Brugia malayi Papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.019 0.019
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0092 0.3245
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.019 0.2083
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0049 0.0048
Entamoeba histolytica cysteine protease, putative 0.0266 0.0827 0.2339
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Onchocerca volvulus 0.1061 0.3456 1
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0032 0.0054 0.0483
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0054
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0173 0.0173
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0266 0.0827 0.2367
Entamoeba histolytica hypothetical protein 0.0266 0.0827 0.2339
Entamoeba histolytica cysteine proteinase, putative 0.0738 0.239 0.6894
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0049 0.0048
Brugia malayi Doublecortin family protein 0.0019 0.0011 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1124 0.3664 1
Trypanosoma brucei cysteine peptidase C (CPC) 0.1124 0.3664 1
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0173 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0032 0.0054 0.0483
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0738 0.239 0.6509
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0322 0.1014 0.1013
Loa Loa (eye worm) voltage-dependent calcium channel 0.0026 0.0035 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma cruzi hexose transporter 0.0032 0.0054 0.0054
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Brugia malayi PHD-finger family protein 0.0026 0.0033 0.0032
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0074 0.0366
Mycobacterium tuberculosis Conserved protein 0.0043 0.0092 0.0927
Echinococcus granulosus cathepsin b 0.3039 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0588 0.1893 0.5146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0225 0.2494
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0151 0.015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0055 0.0131 0.013
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0032 0.0054 0.0483
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0186 0.0564 0.0563
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0103 0.0289 0.0288
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Mycobacterium ulcerans hypothetical protein 0.0043 0.0092 0.0498
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0266 0.0827 0.2205
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0053 0.0122
Loa Loa (eye worm) hypothetical protein 0.0738 0.239 0.2389
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0042 0.0042
Loa Loa (eye worm) cysteine protease 0.1061 0.3456 0.3455
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Loa Loa (eye worm) cytochrome P450 0.0032 0.0054 0.0053
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0053 0.0122
Schistosoma mansoni hypothetical protein 0.0035 0.0062 0.0062
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Brugia malayi jmjC domain containing protein 0.0093 0.0255 0.0254
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0046 0.0045
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0067 0.0169 0.0169
Plasmodium falciparum serine repeat antigen 1 0.0266 0.0827 0.2367
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Brugia malayi nuclear hormone receptor 0.0031 0.0049 0.0048
Schistosoma mansoni hypothetical protein 0.0021 0.0018 0.0018
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Brugia malayi Cam kinase protein 1 0.0032 0.0053 0.0052
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Entamoeba histolytica protein kinase, putative 0.0032 0.0053 0.0085
Schistosoma mansoni zinc finger protein 0.002 0.0015 0.0015
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0073 0.0189 0.0188
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0256 0.2856
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0266 0.0827 0.0827
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0032 0.0054 0.0219
Schistosoma mansoni hypothetical protein 0.0016 0.0001 0.0001
Schistosoma mansoni polycystin 1-related 0.0019 0.0011 0.0011
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Giardia lamblia Kinase, PLK 0.0098 0.0272 0.068
Trichomonas vaginalis sugar transporter, putative 0.0032 0.0054 0.0107
Onchocerca volvulus 0.0738 0.239 0.6905
Brugia malayi Cathepsin L-like precursor 0.1061 0.3456 0.3455
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Onchocerca volvulus 0.006 0.0146 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Loa Loa (eye worm) hypothetical protein 0.0032 0.0053 0.0052
Schistosoma mansoni hypothetical protein 0.0019 0.0011 0.0011
Onchocerca volvulus Alhambra homolog 0.0028 0.0042 0.0088
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.005 0.0049
Trypanosoma cruzi cysteine protease, putative 0.0588 0.1893 0.1893
Echinococcus granulosus zinc finger protein 0.002 0.0015 0.0014
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0867 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0588 0.1893 0.5166
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0049 0.0048
Toxoplasma gondii transporter, cation channel family protein 0.0026 0.0035 0.007
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0032 0.0054 0.0483
Brugia malayi Bromodomain containing protein 0.0039 0.0078 0.0078
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0092 0.0927
Trypanosoma cruzi cysteine peptidase, putative 0.0588 0.1893 0.1893
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0049 0.0048
Onchocerca volvulus 0.1061 0.3456 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1124 0.3664 0.3664
Echinococcus granulosus histone lysine methyltransferase setb 0.0077 0.0204 0.0203
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0049 0.0048
Giardia lamblia Cysteine protease 0.0266 0.0827 0.2205
Trypanosoma cruzi cysteine proteinase, putative 0.0588 0.1893 0.1893
Trypanosoma brucei glucose transporter, putative 0.0032 0.0054 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0032 0.0054 0.0483
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0266 0.0827 0.0826
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0151 0.015
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0173
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0173 0.0472
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0074
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0661 0.1772
Plasmodium vivax serine-repeat antigen (SERA) 0.0266 0.0827 0.2367
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0074 0.0201
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0074 0.0145
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0186 0.0564 0.0564
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0032 0.0054 0.0219
Trichomonas vaginalis glutaminase, putative 0.0434 0.1382 0.3748
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Loa Loa (eye worm) cytochrome P450 family protein 0.0043 0.0089 0.0088
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0043 0.0089 0.0477
Echinococcus granulosus cytochrome P450 2K1 0.0032 0.0054 0.0053
Brugia malayi jmjC domain containing protein 0.0036 0.0068 0.0067
Schistosoma mansoni coup transcription factor 0.0031 0.0049 0.0049
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0062 0.0061
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0266 0.0827 0.2367
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0092 0.0211
Echinococcus granulosus cathepsin b 0.3039 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0092 0.025
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0266 0.0827 0.2225
Brugia malayi beta-lactamase family protein 0.0043 0.0092 0.0091
Plasmodium falciparum hexose transporter 0.0103 0.0289 0.0806
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0078 0.0078
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0025 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0065
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0266 0.0827 0.0826
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0018 0.0017
Toxoplasma gondii cathepsin CPC1 0.0266 0.0827 0.2236
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Brugia malayi Papain family cysteine protease containing protein 0.0588 0.1893 0.1892
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0266 0.0827 0.2339
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0007
Loa Loa (eye worm) cathepsin B 0.1124 0.3664 0.3663
Brugia malayi Cytochrome P450 family protein 0.0043 0.0089 0.0088
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0049 0.0048
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1061 0.3456 0.3455
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0588 0.1893 0.1893
Loa Loa (eye worm) sugar transporter 0.0103 0.0289 0.0288
Brugia malayi ecdysteroid receptor 0.0031 0.0049 0.0048
Trypanosoma cruzi cytochrome P450, putative 0.0043 0.0089 0.0089
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0024
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Loa Loa (eye worm) hypothetical protein 0.0019 0.0011 0.001
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0092 0.0927
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium falciparum cysteine proteinase falcipain 3 0.1061 0.3456 1
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.019 0.019
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Onchocerca volvulus 0.0474 0.1517 0.4371
Loa Loa (eye worm) hypothetical protein 0.0043 0.0092 0.0091
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.3039 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.019 0.1225
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0256 0.2856
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0266 0.0827 0.2225
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1061 0.3456 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0266 0.0827 0.0827
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0053 0.0122
Giardia lamblia Cathepsin B precursor 0.1124 0.3664 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1061 0.3456 0.943
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Brugia malayi beta-lactamase family protein 0.0043 0.0092 0.0091
Trypanosoma cruzi cysteine peptidase, putative 0.1061 0.3456 0.3456
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0049 0.0048
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0049 0.0049
Loa Loa (eye worm) hypothetical protein 0.0035 0.0062 0.0061
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0042 0.0087
Onchocerca volvulus 0.1061 0.3456 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0032 0.0054 0.0219
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0272 0.0272
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.0054 0.0146
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0067 0.0169 0.0462
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0025 0.0024
Loa Loa (eye worm) beta-lactamase 0.0043 0.0092 0.0091
Mycobacterium leprae Conserved hypothetical protein 0.0032 0.0054 0.169
Brugia malayi Papain family cysteine protease containing protein 0.0588 0.1893 0.1892
Onchocerca volvulus 0.0266 0.0827 0.2367
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0049 0.0048
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0053 0.0052
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0266 0.0827 0.2205
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0266 0.0827 0.2367
Echinococcus granulosus cathepsin l1 0.1061 0.3456 0.3455
Brugia malayi follicle stimulating hormone receptor 0.0225 0.0693 0.0692
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0053 0.0122
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0068 0.0068
Echinococcus multilocularis cathepsin L 0.0588 0.1893 0.1892
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0146 0.0372
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0006 0.0005
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0225 0.2494
Giardia lamblia Cathepsin L precursor 0.0266 0.0827 0.2205
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0266 0.0827 0.2225
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0016 0.0001 0.0001
Echinococcus granulosus cathepsin l cysteine peptidase 0.1061 0.3456 0.3455
Onchocerca volvulus 0.0043 0.0092 0.0233
Mycobacterium leprae Probable lipase LipE 0.0043 0.0092 0.3245
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0077 0.0204 0.0204
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0032 0.0054 0.0483
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0024 0.0026
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0272 0.0755
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0032 0.0054 0.0483
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0049 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.001 0.0009
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.007 0.007
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1061 0.3456 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.007 0.0069
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0011 0.001
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0042 0.0087
Brugia malayi nuclear receptor NHR-88 0.0031 0.0049 0.0048
Plasmodium vivax SET domain protein, putative 0.006 0.0146 0.039
Brugia malayi Pre-SET motif family protein 0.0417 0.1326 0.1326
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0032 0.0054 0.0219
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0025 0.0025
Loa Loa (eye worm) hypothetical protein 0.0266 0.0827 0.0826
Entamoeba histolytica cysteine protease, putative 0.0588 0.1893 0.5445
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0272 0.0271
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0055 0.0131 0.013
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0049 0.0049
Entamoeba histolytica cysteine proteinase, putative 0.0588 0.1893 0.5445
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0588 0.1893 0.5146
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0225 0.2494
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0074 0.0162
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0266 0.0827 0.0826
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0173 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0049 0.0048
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0049 0.0048
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0111 0.0265
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0625 0.1781
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0053 0.0122
Echinococcus granulosus cathepsin L cysteine protease 0.0588 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.0031 0.0049 0.0048
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0139 0.0409 0.0408
Onchocerca volvulus Huntingtin homolog 0.0063 0.0155 0.0418
Trypanosoma brucei trypanothione reductase 0.0037 0.007 0.019
Loa Loa (eye worm) hypothetical protein 0.0322 0.1014 0.1013
Trypanosoma brucei cytochrome P450, putative 0.0043 0.0089 0.0242
Schistosoma mansoni rab6-interacting 0.0019 0.0011 0.0011
Brugia malayi cathepsin Z-like cysteine proteinase 0.0266 0.0827 0.0826
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0092 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0272 0.0704
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0979 0.2644
Trypanosoma brucei glucose transporter 1E 0.0032 0.0054 0.0146
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Leishmania major cathepsin L-like protease 0.1061 0.3456 0.9433
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0146 0.0145
Plasmodium vivax glutathione reductase, putative 0.0037 0.007 0.0169
Leishmania major cysteine peptidase A (CPA) 0.1061 0.3456 0.9433
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0032 0.0054 0.0483
Leishmania major hypothetical protein, conserved 0.0043 0.0092 0.025
Brugia malayi Bromodomain containing protein 0.0031 0.005 0.0049
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0006 0.0006
Brugia malayi Cathepsin L-like precursor 0.0738 0.239 0.2389
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0046 0.0045
Plasmodium falciparum serine repeat antigen 7 0.0266 0.0827 0.2367
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0074 0.5
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0225 0.873
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0123 0.0356 0.0356
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0266 0.0827 0.2367
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0049 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0266 0.0827 0.2225
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Plasmodium falciparum mitogen-activated protein kinase 2 0.0167 0.05 0.1418
Schistosoma mansoni cathepsin S (C01 family) 0.0266 0.0827 0.0827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0032 0.0054 0.0483
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0092 0.0211
Giardia lamblia Cathepsin L-like protease 0.0266 0.0827 0.2205
Onchocerca volvulus Huntingtin homolog 0.0063 0.0155 0.0418
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0266 0.0827 0.2225
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0024 0.0037
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0417 0.1326 0.1326
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1061 0.3456 0.9433
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0049 0.0049
Echinococcus granulosus cathepsin L cysteine proteinase 0.1061 0.3456 0.3455
Plasmodium falciparum protein kinase 7 0.0292 0.0912 0.2616
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1061 0.3456 0.943
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0092 0.0091
Schistosoma mansoni cathepsin F (C01 family) 0.1061 0.3456 0.3456
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0067 0.0067
Toxoplasma gondii cytochrome p450 superfamily protein 0.0032 0.0054 0.012
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0032 0.0054 0.0054
Brugia malayi fibroinase precursor 0.0266 0.0827 0.0826
Giardia lamblia Cathepsin B precursor 0.0266 0.0827 0.2205
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0032 0.0054 0.0219
Entamoeba histolytica cysteine protease, putative 0.1061 0.3456 1

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp1a2 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c9 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2d6 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 14.12537545 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp3a4 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
AC50 (functional) = 15.84893192 uM PUBCHEM_BIOASSAY: Cytochrome panel assay with activity outcomes. (Class of assay: other) Panel member name: p450-cyp2c19 Compounds with AC50 equal or less than 10 uM are considered active ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 56.2341 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) = 79.4328 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of DNA Polymerase Beta. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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