Detailed information for compound 140430

Basic information

Technical information
  • TDR Targets ID: 140430
  • Name: (2S)-2-(3-phenylpropanoylamino)-3-[4-(4-piper idin-4-ylbutoxy)phenyl]propanoic acid
  • MW: 452.586 | Formula: C27H36N2O4
  • H donors: 3 H acceptors: 3 LogP: 2.28 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N[C@H](C(=O)O)Cc1ccc(cc1)OCCCCC1CCNCC1)CCc1ccccc1
  • InChi: 1S/C27H36N2O4/c30-26(14-11-21-6-2-1-3-7-21)29-25(27(31)32)20-23-9-12-24(13-10-23)33-19-5-4-8-22-15-17-28-18-16-22/h1-3,6-7,9-10,12-13,22,25,28H,4-5,8,11,14-20H2,(H,29,30)(H,31,32)/t25-/m0/s1
  • InChiKey: BLFXKDDGAIEYJZ-VWLOTQADSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-(3-phenylpropanoylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propanoic acid
  • (2S)-2-[(1-oxo-3-phenylpropyl)amino]-3-[4-[4-(4-piperidinyl)butoxy]phenyl]propanoic acid
  • (2S)-2-(hydrocinnamoylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propionic acid
  • (2S)-2-(3-phenylpropanoylamino)-3-[4-[4-(4-piperidyl)butoxy]phenyl]propionic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma mansoni integrin alpha Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129341 All targets in OG5_129341
Brugia malayi Integrin alpha pat-2 precursor Get druggable targets OG5_129341 All targets in OG5_129341
Loa Loa (eye worm) integrin alpha pat-2 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum ko:K06476 integrin alpha 2B, putative Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus multilocularis integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
Schistosoma japonicum IPR013513,Integrin alpha chain, C-terminal cytoplasmic region,domain-containing Get druggable targets OG5_129341 All targets in OG5_129341
Echinococcus granulosus integrin alpha 3 Get druggable targets OG5_129341 All targets in OG5_129341
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis serine protein kinase ATM 0.0019 0.0001 0.0001
Echinococcus multilocularis GPCR, family 2 0.0384 0.0157 0.0157
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0924 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0924 0.0388 0.2605
Echinococcus granulosus lamin dm0 0.026 0.0104 0.0104
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0232 0.0092 0.0618
Brugia malayi Calcitonin receptor-like protein seb-1 0.1215 0.0513 0.3441
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Echinococcus multilocularis integrin alpha 3 0.0142 0.0053 0.0053
Trypanosoma cruzi DNA topoisomerase II, putative 0.0033 0.0007 0.0163
Mycobacterium tuberculosis Conserved protein 0.0232 0.0092 0.0096
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0039 0.0009 0.0231
Brugia malayi Steroid receptor seven-up type 2 0.0032 0.0007 0.0044
Loa Loa (eye worm) transcription factor SMAD2 0.2119 0.0899 0.6039
Echinococcus multilocularis ecdysone induced protein 78C 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0049 0.0014 0.0093
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.01 0.0035 0.0904
Mycobacterium tuberculosis Probable esterase LipL 0.0232 0.0092 0.0096
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0232 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0001 0.001
Brugia malayi Intermediate filament tail domain containing protein 0.026 0.0104 0.0699
Loa Loa (eye worm) TAR-binding protein 0.0211 0.0083 0.0557
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0001 0.0001
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0018 0.0121
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0089
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0046 0.0012 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0027 0.068
Trypanosoma brucei TPR repeat/SET domain containing protein, putative 0.0019 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0384 0.0157 0.0157
Trypanosoma cruzi PAB1-binding protein , putative 0.008 0.0027 0.068
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Echinococcus granulosus histone lysine N methyltransferase MLL5 0.0019 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0035 0.0205
Brugia malayi hypothetical protein 0.008 0.0027 0.018
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Trichomonas vaginalis ferritin, putative 0.0082 0.0028 0.0158
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0404 0.0165 0.0165
Schistosoma mansoni lamin 0.026 0.0104 0.0104
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0026 0.0004 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0232 0.0092 0.2365
Echinococcus granulosus zinc finger protein 0.0028 0.0005 0.0005
Trypanosoma brucei predicted SET domain protein 0.0019 0.0001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 2.2001 0.9409 1
Loa Loa (eye worm) histone methyltransferase 0.0028 0.0005 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0384 0.0157 0.0157
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0522 0.0216 0.0216
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0384 0.0157 0.1055
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Brugia malayi MH1 domain containing protein 0.008 0.0027 0.018
Loa Loa (eye worm) hypothetical protein 0.0145 0.0055 0.0367
Leishmania major cathepsin L-like protease 0.0048 0.0013 0.0325
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0019 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Schistosoma mansoni ferritin 0.0082 0.0028 0.0028
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0007 0.017
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Echinococcus multilocularis integrin alpha ps 0.0083 0.0028 0.0028
Loa Loa (eye worm) nuclear factor I 0.008 0.0027 0.018
Loa Loa (eye worm) hypothetical protein 0.0121 0.0044 0.0298
Trichomonas vaginalis esterase, putative 0.0232 0.0092 0.0539
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Schistosoma mansoni tar DNA-binding protein 0.0211 0.0083 0.0083
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0007 0.0007
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0047 0.0013 0.0322
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0018 0.0103
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Echinococcus multilocularis dnaJ subfamily B 0.0433 0.0178 0.0178
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0032 0.0007 0.0044
Trypanosoma brucei DNA topoisomerase ii 0.0039 0.0009 0.0231
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.01 0.0035 0.0904
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0032 0.0007 0.0007
Brugia malayi Pre-SET motif family protein 0.0502 0.0208 0.1394
Schistosoma mansoni enhancer of zeste ezh 0.0019 0.0001 0.0001
Trypanosoma cruzi hypothetical protein, conserved 0.0232 0.0092 0.2365
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0032 0.0007 0.0044
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0007 0.0044
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0924 0.0388 1
Loa Loa (eye worm) RNA binding protein 0.0211 0.0083 0.0557
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.01 0.0035 0.0904
Mycobacterium leprae conserved hypothetical protein 0.0232 0.0092 0.0083
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.01 0.0035 0.0904
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Echinococcus granulosus mixed lineage leukemia protein mll 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0924 0.0388 0.2276
Loa Loa (eye worm) integrin alpha pat-2 0.0285 0.0115 0.0769
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0014 0.0013
Leishmania major cathepsin L-like protease 0.0048 0.0013 0.0325
Brugia malayi MH1 domain containing protein 0.0144 0.0054 0.0366
Plasmodium falciparum DNA topoisomerase 2 0.0035 0.0008 0.0173
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0008 0.0197
Echinococcus multilocularis SET (trithorax:polycomb) domain containing protein 0.0019 0.0001 0.0001
Echinococcus granulosus ferritin 0.0082 0.0028 0.0028
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0384 0.0157 0.0157
Echinococcus multilocularis lamin 0.026 0.0104 0.0104
Echinococcus multilocularis dna polymerase eta 0.0053 0.0015 0.0015
Echinococcus granulosus SET and MYND domain containing protein 4 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.014 0.0052 0.0352
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0083 0.0028 0.0028
Echinococcus granulosus mothers against decapentaplegic 6 0.0065 0.002 0.002
Brugia malayi MH2 domain containing protein 0.2119 0.0899 0.6039
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0008 0.0197
Loa Loa (eye worm) hypothetical protein 0.0021 0.0002 0.0011
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0924 0.0388 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0002 0.0044
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0001 0.0006
Echinococcus multilocularis Smad4 0.0144 0.0054 0.0054
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0019 0.0001 0.0001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0005 0.0105
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0082 0.0028 0.0028
Echinococcus multilocularis ferritin 0.0082 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0049 0.0014 0.0093
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.01 0.0035 0.0896
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0014 0.0013
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0001 0.001
Schistosoma mansoni set and mynd domain containing 0.0019 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.002 0.0116
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Brugia malayi Probable DNA topoisomerase II 0.0035 0.0008 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Schistosoma mansoni ferritin light chain 0.0082 0.0028 0.0028
Toxoplasma gondii DNA topoisomerase 2, putative 0.0035 0.0008 0.0175
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0035 0.0008 0.0051
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.0037
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0019 0.0001 0.0001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.3497 0.1489 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Echinococcus granulosus intermediate filament protein 0.026 0.0104 0.0104
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0014 0.0338
Schistosoma mansoni hypothetical protein 0.0384 0.0157 0.0157
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0002 0.0002
Brugia malayi photoreceptor-specific nuclear receptor 0.0032 0.0007 0.0044
Echinococcus granulosus cpg binding protein 0.0034 0.0007 0.0007
Echinococcus granulosus SET domain containing protein 3 0.0019 0.0001 0.0001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0001 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0018 0.0103
Schistosoma mansoni integrin alpha-ps 0.0083 0.0028 0.0028
Echinococcus granulosus jumonji domain containing protein 0.004 0.001 0.001
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0032 0.0007 0.0044
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0019 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0032 0.0007 0.0007
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0924 0.0388 0.0388
Brugia malayi latrophilin 2 splice variant baaae 0.083 0.0348 0.2337
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0088
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi PHD-finger family protein 0.0029 0.0005 0.0033
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0034 0.0007 0.0007
Mycobacterium tuberculosis Conserved protein 0.0232 0.0092 0.0096
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0619 0.0258 0.173
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Echinococcus multilocularis lamin dm0 0.026 0.0104 0.0104
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0483 0.0199 0.0199
Echinococcus granulosus flap endonuclease 1 0.0026 0.0004 0.0004
Trichomonas vaginalis set domain proteins, putative 0.398 0.1696 1
Leishmania major hypothetical protein, conserved 0.0232 0.0092 0.2365
Leishmania major DNA polymerase eta, putative 0.0053 0.0015 0.0387
Leishmania major cathepsin L-like protease 0.0048 0.0013 0.0325
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0018
Loa Loa (eye worm) steroid hormone receptor 0.0032 0.0007 0.0044
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0009 0.021
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Onchocerca volvulus 0.0619 0.0258 0.1506
Echinococcus granulosus histone lysine n methyltransferase setd8 0.0019 0.0001 0.0001
Mycobacterium ulcerans bacterioferritin BfrA 0.0082 0.0028 0.0028
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0232 0.0092 0.0618
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0008 0.0007
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0034 0.0007 0.0007
Loa Loa (eye worm) SET domain-containing protein 0.0019 0.0001 0.0006
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus granulosus mothers against decapentaplegic 2 0.0065 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET2 0.0019 0.0001 0.0002
Chlamydia trachomatis DNA gyrase subunit B 0.002 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.004 0.001 0.0065
Schistosoma mansoni cpg binding protein 0.0034 0.0007 0.0007
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.8363 0.3572 1
Echinococcus granulosus histone lysine N methyltransferase SETD2 0.0019 0.0001 0.0001
Plasmodium vivax ataxin-2 like protein, putative 0.008 0.0027 0.067
Schistosoma mansoni tar DNA-binding protein 0.0211 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.004 0.001 0.001
Schistosoma mansoni steroid hormone receptor ad4bp 0.0032 0.0007 0.0007
Echinococcus granulosus dna polymerase eta 0.0053 0.0015 0.0015
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0014 0.0338
Schistosoma mansoni integrin alpha-ps 0.0043 0.0011 0.0011
Toxoplasma gondii target of rapamycin (TOR), putative 0.0074 0.0025 0.0613
Brugia malayi Protein set-1 0.0019 0.0001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.01 0.0035 0.0035
Schistosoma mansoni Smad4 0.0144 0.0054 0.0054
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0002 0.0052
Onchocerca volvulus 0.0049 0.0014 0.0067
Loa Loa (eye worm) hypothetical protein 0.0056 0.0017 0.0111
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0035 0.0205
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0002 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0032 0.0007 0.0007
Schistosoma mansoni set and mynd domain containing 0.0019 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Schistosoma mansoni DNA topoisomerase II 0.0035 0.0008 0.0008
Brugia malayi CXXC zinc finger family protein 0.003 0.0006 0.0038
Brugia malayi ecdysteroid receptor 0.0032 0.0007 0.0044
Brugia malayi RNA binding protein 0.0211 0.0083 0.0557
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0057
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 2.2001 0.9409 1
Schistosoma mansoni coup transcription factor 0.0032 0.0007 0.0007
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0502 0.0208 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0027 0.0153
Entamoeba histolytica hypothetical protein 0.0019 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0232 0.0092 0.0618
Trypanosoma brucei unspecified product 0.0023 0.0002 0.0052
Leishmania major DNA topoisomerase ii 0.0033 0.0007 0.0163
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0034 0.0007 0.017
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0014 0.0013
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus multilocularis beta LACTamase domain containing family member 0.0232 0.0092 0.0092
Onchocerca volvulus 0.1007 0.0424 0.2487
Leishmania major mitochondrial DNA topoisomerase II 0.0039 0.0009 0.0231
Echinococcus multilocularis FTZ F1 alpha 0.0032 0.0007 0.0007
Schistosoma mansoni ferritin 0.0082 0.0028 0.0028
Schistosoma mansoni ran binding protein 9-related 0.0019 0.0001 0.0001
Brugia malayi beta-lactamase family protein 0.0232 0.0092 0.0618
Toxoplasma gondii ABC1 family protein 0.0232 0.0092 0.2358
Echinococcus multilocularis peregrin 0.0035 0.0008 0.0008
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.8363 0.3572 1
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0024 0.0003 0.0001
Brugia malayi jmjC domain containing protein 0.0039 0.0009 0.0062
Schistosoma mansoni apoferritin-2 0.0082 0.0028 0.0028
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0009 0.0062
Trypanosoma cruzi DNA topoisomerase II, putative 0.0033 0.0007 0.0163
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0012 0.0282
Loa Loa (eye worm) hypothetical protein 0.0232 0.0092 0.0618
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0002 0.0002
Echinococcus granulosus Smad4 0.0144 0.0054 0.0054
Trichomonas vaginalis D-aminoacylase, putative 0.0232 0.0092 0.0539
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0032 0.0007 0.0044
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0126 0.0046 0.0046
Echinococcus multilocularis integrin alpha ps 0.0083 0.0028 0.0028
Loa Loa (eye worm) hypothetical protein 0.0024 0.0003 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Giardia lamblia DINP protein human, muc B family 0.0023 0.0002 0.0042
Loa Loa (eye worm) TOPoisomerase family member 0.0035 0.0008 0.0051
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0007 0.017
Trypanosoma cruzi DNA polymerase eta, putative 0.0053 0.0015 0.0387
Loa Loa (eye worm) beta-lactamase 0.0232 0.0092 0.0618
Plasmodium vivax DNA gyrase subunit B, putative 0.002 0.0001 0.0013
Schistosoma mansoni SET domain protein 0.0019 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0019 0.0001 0.0005
Trichomonas vaginalis flap endonuclease-1, putative 0.0026 0.0004 0.0018
Treponema pallidum bacterioferrin (TpF1) 0.0082 0.0028 0.0073
Trichomonas vaginalis PIKK family atypical protein kinase 0.0085 0.0029 0.0168
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0019 0.0001 0.0008
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0039 0.0009 0.0231
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0027 0.0153
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0007 0.0044
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0002 0.001
Mycobacterium leprae Probable lipase LipE 0.0232 0.0092 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0021 0.0122
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Plasmodium falciparum DNA gyrase subunit B 0.002 0.0001 0.0013
Schistosoma mansoni hypothetical protein 0.0036 0.0008 0.0008
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0084 0.0029 0.0192
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0032 0.0007 0.0007
Brugia malayi Integrin alpha cytoplasmic region family protein 0.014 0.0052 0.0352
Schistosoma mansoni microtubule-associated protein tau 2.3382 1 1
Schistosoma mansoni Smad4 0.0065 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.002 0.0001 0.0009
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0924 0.0388 0.0388
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0026 0.0004 0.0086
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0032 0.0007 0.0044
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0009 0.0204
Brugia malayi Bromodomain containing protein 0.0049 0.0014 0.0092
Loa Loa (eye worm) MH2 domain-containing protein 0.2119 0.0899 0.6039
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0032 0.0007 0.0044
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0121 0.0044 0.0298
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0032 0.0007 0.0044
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0036 0.0008 0.0008
Brugia malayi MH2 domain containing protein 0.0065 0.002 0.0136
Echinococcus multilocularis expressed protein 0.0082 0.0028 0.0028
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0015 0.0104
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi MH1 domain containing protein 0.0144 0.0054 0.0366
Loa Loa (eye worm) hypothetical protein 0.1215 0.0513 0.3441
Loa Loa (eye worm) acetyltransferase 0.0144 0.0054 0.0365
Plasmodium falciparum flap endonuclease 1 0.0026 0.0004 0.0076
Schistosoma mansoni hypothetical protein 0.0029 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0256 0.0102 0.0685
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0032 0.0007 0.0007
Trypanosoma cruzi cruzipain precursor, putative 0.0048 0.0013 0.0325
Echinococcus granulosus ecdysone induced protein 78C 0.0032 0.0007 0.0007
Schistosoma mansoni smad1 5 8 and 0.0144 0.0054 0.0054
Trypanosoma cruzi TPR repeat/SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0008 0.0008
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0373 0.0152 0.0152
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0002 0.0002
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0012 0.0064
Trypanosoma cruzi D-ala D-ala ligase C-terminus/SET domain containing protein, putative 0.0019 0.0001 0.001
Entamoeba histolytica hypothetical protein 0.0019 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0049 0.0014 0.0092
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0021 0.0002 0.0024
Brugia malayi Bromodomain containing protein 0.0035 0.0008 0.0051
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0054 0.0054
Brugia malayi TAR-binding protein 0.0211 0.0083 0.0557
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0019 0.0001 0.0001
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Schistosoma mansoni retinoic acid receptor RXR 0.0032 0.0007 0.0007
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0014 0.0346
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0005 0.0005
Loa Loa (eye worm) phosphatidylinositol 3 0.01 0.0035 0.0238
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0049 0.0014 0.0093
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0014 0.0093
Loa Loa (eye worm) intermediate filament protein 0.026 0.0104 0.0699
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0008 0.0007
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Brugia malayi intermediate filament protein 0.026 0.0104 0.0699
Schistosoma mansoni set and mynd domain containing 0.0019 0.0001 0.0001
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0033 0.0033
Trypanosoma brucei ATP-grasp domain containing protein, putative 0.0019 0.0001 0.001
Onchocerca volvulus 0.398 0.1696 1
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0019 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0013 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0032 0.0007 0.0044
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0924 0.0388 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0014 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Echinococcus granulosus mothers against decapentaplegic 5 0.0144 0.0054 0.0054
Echinococcus granulosus FTZ F1 alpha 0.0032 0.0007 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0032 0.0007 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0032 0.0007 0.0007
Entamoeba histolytica Flap nuclease, putative 0.0026 0.0004 0.0078
Schistosoma mansoni ferritin 0.0082 0.0028 0.0028
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0034 0.0007 0.017
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.008 0.0027 0.0679
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.01 0.0035 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0076 0.0025 0.0025
Brugia malayi Flap endonuclease-1 0.0026 0.0004 0.0025
Schistosoma mansoni DNA polymerase eta 0.0053 0.0015 0.0015
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Plasmodium vivax DNA topoisomerase II, putative 0.0035 0.0008 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.01 0.0035 0.0238
Trypanosoma cruzi D-ala D-ala ligase C-terminus/SET domain containing protein, putative 0.0019 0.0001 0.001
Entamoeba histolytica hypothetical protein, conserved 0.0019 0.0001 0.0002
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0404 0.0165 0.0165
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0002 0.0052
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0009 0.0009
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0002 0.001
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0232 0.0092 0.0618
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0024 0.0003 0.0001
Echinococcus granulosus SET trithorax:polycomb domain containing protein 0.0019 0.0001 0.0001
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0033 0.0007 0.0163
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Echinococcus multilocularis histone lysine N methyltransferase SETD2 0.0019 0.0001 0.0001
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0029 0.0005 0.0033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0018 0.0102
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0384 0.0157 0.1055
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0502 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.083 0.0348 0.2337
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.01 0.0035 0.0904
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0054 0.0366
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0924 0.0388 0.0388
Schistosoma mansoni smad 0.0065 0.002 0.002
Trypanosoma cruzi major cysteine proteinase, putative 0.0037 0.0009 0.0213
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi PHD-finger family protein 0.0035 0.0008 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0924 0.0388 0.2284
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0026 0.0004 0.0086
Onchocerca volvulus 0.026 0.0104 0.0599
Trypanosoma cruzi TPR repeat/SET domain containing protein, putative 0.0019 0.0001 0.001
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus multilocularis integrin alpha ps 0.004 0.001 0.001
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0002 0.0017
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0019 0.0001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0065 0.002 0.0136
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0003 0.0021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0008 0.0007
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0001 0.0001
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0002 0.0001
Brugia malayi steroid hormone receptor 0.0032 0.0007 0.0044
Echinococcus multilocularis SET and MYND domain containing protein 4 0.0019 0.0001 0.0001
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0014 0.0013
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0014 0.0013
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0373 0.0152 0.0152
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 2.2001 0.9409 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0002 0.0005
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0502 0.0208 0.5341
Onchocerca volvulus 0.0232 0.0092 0.0529
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0002 0.0052
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0002 0.0002
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.001 0.0064
Echinococcus multilocularis myeloid:lymphoid or mixed lineage leukemia 5 0.0019 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.0144 0.0054 0.0054
Echinococcus granulosus beta LACTamase domain containing family member 0.0232 0.0092 0.0092
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0009 0.021
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Schistosoma mansoni RAR-like nuclear receptor 0.0032 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Trichomonas vaginalis DNA topoisomerase II, putative 0.0035 0.0008 0.004
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Onchocerca volvulus Bile acid receptor homolog 0.0032 0.0007 0.0023
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0014 0.0093
Entamoeba histolytica hypothetical protein 0.0019 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0057
Brugia malayi beta-lactamase 0.0232 0.0092 0.0618
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0002 0.0002
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0043 0.0011 0.0075
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Schistosoma mansoni thyroid hormone receptor 0.0436 0.0179 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0032 0.0007 0.0044
Echinococcus multilocularis zinc finger protein 0.0028 0.0005 0.0005
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0924 0.0388 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.0009 0.0009
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Toxoplasma gondii histone lysine methyltransferase SET8 0.0019 0.0001 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0089
Loa Loa (eye worm) SET domain-containing protein 0.0019 0.0001 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Loa Loa (eye worm) hypothetical protein 0.026 0.0104 0.0699
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0051 0.0051
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0076 0.0025 0.0025
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0034 0.0007 0.0007
Brugia malayi Bromodomain containing protein 0.0094 0.0033 0.0222
Schistosoma mansoni SET domain protein 0.0023 0.0003 0.0003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0007 0.0007
Loa Loa (eye worm) Smad1 0.0144 0.0054 0.0366
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0088
Schistosoma mansoni zinc finger protein 0.0028 0.0005 0.0005
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0001 0.001
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0032 0.0007 0.0044
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Brugia malayi SET domain containing protein 0.0023 0.0003 0.0017
Echinococcus granulosus SET and MYND domain containing protein 5 0.0019 0.0001 0.0001
Brugia malayi hypothetical protein 0.0373 0.0152 0.1021
Echinococcus granulosus dna polymerase kappa 0.0023 0.0002 0.0002
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0044 0.0011 0.028
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0005 0.0005
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0014 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.008 0.0027 0.0672
Schistosoma mansoni flap endonuclease-1 0.0023 0.0003 0.0003
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) hypothetical protein 0.0522 0.0216 0.1452
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0005 0.0033
Echinococcus multilocularis histone lysine N methyltransferase NSD3 0.0019 0.0001 0.0001
Schistosoma mansoni ferritin 0.0082 0.0028 0.0028
Loa Loa (eye worm) latrophilin receptor protein 2 0.0384 0.0157 0.1055
Loa Loa (eye worm) SET domain-containing protein 0.0019 0.0001 0.0006
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0032 0.0007 0.0044
Schistosoma mansoni hypothetical protein 0.083 0.0348 0.0348
Brugia malayi cytoplasmic intermediate filament protein 0.0139 0.0052 0.0352
Echinococcus granulosus lamin 0.026 0.0104 0.0104
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Entamoeba histolytica hypothetical protein 0.0373 0.0152 0.3909
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0232 0.0092 0.0539
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0012 0.028
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Schistosoma mansoni intermediate filament proteins 0.026 0.0104 0.0104
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Mycobacterium ulcerans esterase/lipase LipP 0.0232 0.0092 0.0096
Schistosoma mansoni lamin 0.026 0.0104 0.0104
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0035 0.0008 0.0008
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0082 0.0028 0.0028
Brugia malayi jmjC domain containing protein 0.0094 0.0033 0.022
Schistosoma mansoni smad 0.0144 0.0054 0.0054
Echinococcus granulosus SET and MYND domain containing protein 4 0.0019 0.0001 0.0001
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0924 0.0388 1
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0924 0.0388 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0042 0.001 0.0258
Echinococcus granulosus integrin alpha 3 0.0142 0.0053 0.0053
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0014 0.0093
Schistosoma mansoni mixed-lineage leukemia 5 mll5 0.0019 0.0001 0.0001
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.01 0.0035 0.0035
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1484 0.0628 0.0666
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Loa Loa (eye worm) hypothetical protein 0.0052 0.0015 0.01
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0057
Plasmodium falciparum phd finger protein, putative 0.0029 0.0005 0.0105
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Leishmania major DNA polymerase eta, putative 0.0037 0.0009 0.0212
Brugia malayi Latrophilin receptor protein 2 0.0384 0.0157 0.1055
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0002 0.0017
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus multilocularis tumor protein p63 0.6882 0.2938 0.2938
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0018 0.0102
Giardia lamblia PHD finger protein 15 0.0029 0.0005 0.0105
Onchocerca volvulus Protein ultraspiracle homolog 0.0032 0.0007 0.0023
Echinococcus granulosus histone lysine N methyltransferase NSD3 0.0019 0.0001 0.0001
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Schistosoma mansoni integrin alpha 0.0185 0.0072 0.0072
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Mycobacterium ulcerans lipase LipD 0.0232 0.0092 0.0096
Trypanosoma brucei conserved protein, unknown function 0.0019 0.0001 0.001
Mycobacterium tuberculosis Probable lipase LipE 0.0232 0.0092 0.0096
Trichomonas vaginalis penicillin-binding protein, putative 0.0232 0.0092 0.0539
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0014 0.0346
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0027 0.067
Brugia malayi Integrin alpha pat-2 precursor 0.0185 0.0072 0.0481
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.0037
Mycobacterium ulcerans hypothetical protein 0.0049 0.0014 0.0013
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0008 0.0021
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0006 0.0038
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0006
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.01 0.0035 0.0896
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1215 0.0513 0.3441
Brugia malayi RNA recognition motif domain containing protein 0.0211 0.0083 0.0557
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0032 0.0007 0.0007
Echinococcus multilocularis SET and MYND domain containing protein 4 0.0019 0.0001 0.0001
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0013 0.0325
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus multilocularis mothers against decapentaplegic 2 0.0065 0.002 0.002
Brugia malayi Pre-SET motif family protein 0.3497 0.1489 1
Onchocerca volvulus 0.0032 0.0007 0.0023
Schistosoma mansoni tar DNA-binding protein 0.0211 0.0083 0.0083
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0232 0.0092 0.0096
Loa Loa (eye worm) MH1 domain-containing protein 0.0065 0.002 0.0136
Entamoeba histolytica hypothetical protein 0.0373 0.0152 0.3909
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0005 0.0107
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.0053 0.0015 0.0104
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Echinococcus granulosus integrin alpha ps 0.0083 0.0028 0.0028
Brugia malayi mothers against decapentaplegic homolog 3 0.0065 0.002 0.0136
Echinococcus granulosus serine protein kinase ATM 0.0019 0.0001 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0074 0.0025 0.014
Loa Loa (eye worm) phosphatidylinositol 3 0.0034 0.0007 0.0047
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0033 0.0033
Echinococcus multilocularis tar DNA binding protein 0.0211 0.0083 0.0083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0008 0.0008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0211 0.0083 0.0083
Plasmodium vivax SET domain protein, putative 0.0502 0.0208 0.534
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0032 0.0007 0.0044
Echinococcus granulosus myeloid:lymphoid or mixed lineage leukemia 5 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0232 0.0092 0.0096
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0012 0.0064
Onchocerca volvulus Alhambra homolog 0.0029 0.0005 0.0014
Echinococcus multilocularis microtubule associated protein 2 2.3382 1 1
Trypanosoma brucei PAB1-binding protein , putative 0.008 0.0027 0.068
Onchocerca volvulus 0.0232 0.0092 0.0529
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0027 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Brugia malayi Smad1 0.0144 0.0054 0.0366
Echinococcus multilocularis thyroid hormone receptor alpha 0.0436 0.0179 0.0179
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0008 0.0007
Schistosoma mansoni smad1 5 8 and 0.0144 0.0054 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0384 0.0157 0.0157
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0144 0.0054 0.0054
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0005 0.0005
Onchocerca volvulus 0.026 0.0104 0.0599
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0027 0.0153
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi TPR repeat/SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0012 0.0282
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0019 0.0001 0.0002
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0019 0.0001 0.0001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0126 0.0046 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.0037
Echinococcus multilocularis musashi 0.026 0.0104 0.0104
Schistosoma mansoni bromodomain containing protein 0.008 0.0027 0.0027
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0232 0.0092 0.0618
Schistosoma mansoni cpg binding protein 0.0034 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0088
Schistosoma mansoni hypothetical protein 0.0025 0.0003 0.0003
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Schistosoma mansoni nuclear hormone receptor 0.0032 0.0007 0.0007
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Schistosoma mansoni cpg binding protein 0.003 0.0006 0.0006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0232 0.0092 0.0096
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0384 0.0157 0.0157
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0014 0.0346
Trypanosoma brucei hypothetical protein, conserved 0.0232 0.0092 0.2365
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0211 0.0083 0.0557
Mycobacterium ulcerans beta-lactamase 0.0232 0.0092 0.0096
Loa Loa (eye worm) hypothetical protein 0.008 0.0027 0.018
Schistosoma mansoni huntingtin interacting protein-related 0.0019 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0384 0.0157 0.0157
Echinococcus multilocularis mothers against decapentaplegic 5 0.0144 0.0054 0.0054
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0859 0.036 0.036
Trypanosoma brucei target of rapamycin kinase 3, putative 0.008 0.0027 0.0679
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0009 0.0212
Plasmodium vivax SET domain containing protein 0.0025 0.0004 0.0069
Schistosoma mansoni set and mynd domain containing 0.0019 0.0001 0.0001
Brugia malayi hypothetical protein 0.0619 0.0258 0.173
Schistosoma mansoni apoferritin-2 0.0082 0.0028 0.0028
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0001
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0007 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0502 0.0208 0.0208
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.002 0.0001 0.0015
Toxoplasma gondii histone lysine methyltransferase SET1 0.0082 0.0028 0.0701
Plasmodium falciparum ataxin-2 like protein, putative 0.008 0.0027 0.067
Trypanosoma cruzi TPR repeat/SET domain containing protein, putative 0.0019 0.0001 0.001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0004 0.002
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 2.2001 0.9409 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0014 0.0013
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Loa Loa (eye worm) flap endonuclease-1 0.0026 0.0004 0.0025
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0009 0.0212
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Schistosoma mansoni histone-lysine n-methyltransferase seto7 0.0019 0.0001 0.0001
Schistosoma mansoni fkbp-rapamycin associated protein 0.0019 0.0001 0.0001
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Echinococcus multilocularis cpg binding protein 0.0034 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0007 0.0044
Schistosoma mansoni tar DNA-binding protein 0.0211 0.0083 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0924 0.0388 1
Onchocerca volvulus 0.0502 0.0208 0.1211
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0032 0.0007 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.008 0.0027 0.0153
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Schistosoma mansoni thyroid hormone receptor 0.0436 0.0179 0.0179
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0032 0.0007 0.0007
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0005 0.0005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0032 0.0007 0.0007
Schistosoma mansoni cellular tumor antigen P53 0.1007 0.0424 0.0424
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0005 0.0005
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0032 0.0007 0.0007
Mycobacterium tuberculosis Probable hydrolase 0.0232 0.0092 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0232 0.0092 0.0539
Echinococcus granulosus histone lysine methyltransferase setb 0.0522 0.0216 0.0216
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0024 0.0003 0.0001
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0522 0.0216 0.0216
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi target of rapamycin kinase 3 0.008 0.0027 0.0679
Loa Loa (eye worm) hypothetical protein 0.0037 0.0008 0.0057
Loa Loa (eye worm) hypothetical protein 0.0126 0.0046 0.0312
Brugia malayi nuclear receptor NHR-88 0.0032 0.0007 0.0044
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0522 0.0216 0.0216
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0014 0.0013
Echinococcus multilocularis flap endonuclease 1 0.0026 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0005
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0232 0.0092 0.0096
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0035 0.0008 0.0008
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0011 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Mycobacterium ulcerans hypothetical protein 0.0232 0.0092 0.0096
Leishmania major hypothetical protein, conserved 0.008 0.0027 0.068
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0005 0.0107
Echinococcus multilocularis smad 0.0144 0.0054 0.0054
Mycobacterium tuberculosis Conserved protein 0.0232 0.0092 0.0096
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0014 0.0338
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0023 0.0002 0.0002
Brugia malayi nuclear hormone receptor 0.0032 0.0007 0.0044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.1215 0.0513 0.3441
Echinococcus granulosus GPCR family 2 0.0384 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0373 0.0152 0.0152
Loa Loa (eye worm) hypothetical protein 0.008 0.0027 0.018
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0144 0.0054 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0032 0.0007 0.0044
Echinococcus multilocularis histone lysine N methyltransferase MLL5 0.0019 0.0001 0.0001
Trypanosoma cruzi ATP-grasp domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi beta-lactamase family protein 0.0232 0.0092 0.0618
Trichomonas vaginalis PIKK family atypical protein kinase 0.01 0.0035 0.0205
Echinococcus multilocularis SET and MYND domain containing protein 5 0.0019 0.0001 0.0001
Entamoeba histolytica DNA topoisomerase II, putative 0.0035 0.0008 0.0175
Brugia malayi SET domain containing protein 0.0019 0.0001 0.0006
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0924 0.0388 0.0388
Echinococcus granulosus TGF beta signal transducer SmadC 0.0144 0.0054 0.0054
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0924 0.0388 0.2605
Loa Loa (eye worm) hypothetical protein 0.0102 0.0036 0.0244
Echinococcus multilocularis mothers against decapentaplegic 6 0.0065 0.002 0.002
Echinococcus granulosus dnaJ subfamily B 0.0433 0.0178 0.0178
Brugia malayi MH1 domain containing protein 0.008 0.0027 0.018
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0019 0.0001 0.0001
Toxoplasma gondii apical complex lysine methyltransferase 0.0019 0.0001 0.0002
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0032 0.0007 0.0007
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0032 0.0007 0.0007
Entamoeba histolytica hypothetical protein 0.0373 0.0152 0.3909
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.026 0.0104 0.0699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0007 0.0044
Echinococcus multilocularis histone lysine n methyltransferase setd8 0.0019 0.0001 0.0001
Brugia malayi MH2 domain containing protein 0.0144 0.0054 0.0366
Schistosoma mansoni hypothetical protein 0.0404 0.0165 0.0165
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0005 0.0005
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0035 0.0008 0.0008
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0002 0.0001
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus granulosus tumor protein p63 0.6882 0.2938 0.2938
Trichomonas vaginalis PIKK family atypical protein kinase 0.006 0.0018 0.0103
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0019 0.0001 0.0008
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0054 0.0054
Giardia lamblia DNA topoisomerase II 0.0033 0.0007 0.0153
Mycobacterium ulcerans bacterioferritin BfrB 0.0082 0.0028 0.0028
Echinococcus granulosus expressed protein 0.0082 0.0028 0.0028
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0139 0.0052 0.0352
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei D-ala D-ala ligase C-terminus/SET domain containing protein, putative 0.0019 0.0001 0.001
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0011 0.0011
Echinococcus multilocularis jumonji domain containing protein 0.004 0.001 0.001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.01 0.0035 0.0904
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0032 0.0007 0.0044
Schistosoma mansoni hypothetical protein 0.0433 0.0178 0.0178
Toxoplasma gondii histone lysine methyltransferase, SET, putative 0.0019 0.0001 0.0002
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0019 0.0001 0.0001
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0924 0.0388 0.0411
Echinococcus granulosus smad 0.0144 0.0054 0.0054
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0082 0.0028 0.0028
Echinococcus multilocularis SET domain containing protein 3 0.0019 0.0001 0.0001
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0054 0.0365
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0032 0.0007 0.0044
Mycobacterium tuberculosis Probable lipase LipD 0.0232 0.0092 0.0096
Onchocerca volvulus 0.0232 0.0092 0.0529
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0032 0.0007 0.0007
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0007 0.0037
Trypanosoma cruzi cysteine peptidase, putative 0.0048 0.0013 0.0325
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0003 0.0021
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0007 0.017
Trichomonas vaginalis penicillin-binding protein, putative 0.0232 0.0092 0.0539
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0924 0.0388 1
Trypanosoma brucei TPR repeat/SET domain containing protein, putative 0.0019 0.0001 0.001
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.0007 0.0044
Echinococcus granulosus tar DNA binding protein 0.0211 0.0083 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0001 0.0001
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0032 0.0007 0.0007
Onchocerca volvulus 0.003 0.0006 0.0018
Echinococcus granulosus peregrin 0.0035 0.0008 0.0008
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0034 0.0007 0.017
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0012 0.0012
Trypanosoma brucei SET domain containing protein, putative 0.0019 0.0001 0.001
Plasmodium vivax hypothetical protein, conserved 0.0232 0.0092 0.2357
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0035 0.0008 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0019 0.0001 0.001
Echinococcus granulosus integrin alpha ps 0.004 0.001 0.001
Trypanosoma cruzi SET domain containing protein, putative 0.0019 0.0001 0.001
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0048 0.0013 0.0325
Entamoeba histolytica hypothetical protein 0.0373 0.0152 0.3909
Trypanosoma brucei DNA polymerase eta, putative 0.0053 0.0015 0.0387
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0004 0.0004
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0026 0.0004 0.0078
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0005 0.0005
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0032 0.0007 0.0044
Loa Loa (eye worm) MH2 domain-containing protein 0.0065 0.002 0.0136
Schistosoma mansoni ferritin light chain 0.0082 0.0028 0.0028
Leishmania major DNA polymerase kappa, putative 0.0023 0.0002 0.0052
Schistosoma mansoni suppressor of variegation 4-20-related 0.0019 0.0001 0.0001
Schistosoma mansoni Smad4 0.0065 0.002 0.002
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0065 0.002 0.0105
Loa Loa (eye worm) MH1 domain-containing protein 0.0144 0.0054 0.0366
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0036 0.0008 0.0008
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0033 0.0007 0.0163
Leishmania major hypothetical protein, conserved 0.0019 0.0001 0.001
Giardia lamblia Flap structure-specific endonuclease 0.0026 0.0004 0.0076
Brugia malayi MH2 domain containing protein 0.0144 0.0054 0.0366
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.1007 0.0424 0.2845
Schistosoma mansoni hypothetical protein 0.0384 0.0157 0.0157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0232 0.0092 0.0092
Giardia lamblia GTOR 0.01 0.0035 0.0894
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0232 0.0092 0.0618
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0082 0.0028 0.0015
Plasmodium vivax flap endonuclease 1, putative 0.0026 0.0004 0.0076
Schistosoma mansoni transcription factor LCR-F1 0.0373 0.0152 0.0152
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0002 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0016 0.0089
Brugia malayi hypothetical protein 0.0051 0.0015 0.0099
Loa Loa (eye worm) hypothetical protein 0.0232 0.0092 0.0618
Leishmania major SET domain protein, putative 0.0019 0.0001 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.1 uM Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light . ChEMBL. 8057299
IC50 (functional) = 0.1 uM Inhibition of platelet aggregation as the concentration necessary to inhibit the change in light . ChEMBL. 8057299

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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