Detailed information for compound 1413405

Basic information

Technical information
  • TDR Targets ID: 1413405
  • Name: N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-(1,3-d ioxoisoindol-2-yl)-3-methylbutanamide
  • MW: 380.394 | Formula: C21H20N2O5
  • H donors: 1 H acceptors: 3 LogP: 2.88 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(C(N1C(=O)c2c(C1=O)cccc2)C(=O)Nc1ccc2c(c1)OCCO2)C
  • InChi: 1S/C21H20N2O5/c1-12(2)18(23-20(25)14-5-3-4-6-15(14)21(23)26)19(24)22-13-7-8-16-17(11-13)28-10-9-27-16/h3-8,11-12,18H,9-10H2,1-2H3,(H,22,24)
  • InChiKey: KFBRSEWDNVAZEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-(1,3-dioxoisoindolin-2-yl)-3-methyl-butanamide
  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-(1,3-dioxo-2-isoindolinyl)-3-methylbutanamide
  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-(1,3-diketoisoindolin-2-yl)-3-methyl-butyramide
  • N-(2,3-dihydro-1,4-benzodioxin-7-yl)-2-(1,3-dioxoisoindol-2-yl)-3-methyl-butanamide
  • Oprea1_415218
  • ST5186233
  • MLS000110407
  • BAS 00842439
  • Oprea1_412334
  • SMR000106337

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi beta-lactamase 0.0043 0.0303 0.03
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0033 0.0185 0.0273
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0275 0.1084
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0396 0.0371
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0296
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0113 0.106 0.1776
Brugia malayi Glycosyl hydrolases family 31 protein 0.0041 0.0275 0.0272
Brugia malayi ecdysteroid receptor 0.0324 0.3359 0.3458
Brugia malayi Nuclear hormone receptor E75 0.0153 0.1494 0.1531
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0303 0.098
Onchocerca volvulus 0.0117 0.1099 0.1108
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0211 0.3017
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0036 0.0216 0.0673
Brugia malayi Smad1 0.0027 0.0122 0.0113
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0186
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0036 0.0216 0.0963
Schistosoma mansoni RAR-like nuclear receptor 0.0324 0.3359 0.5721
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0275 0.0296
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0038
Echinococcus multilocularis lamin 0.009 0.0807 0.0783
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0065 0.0047
Brugia malayi hypothetical protein 0.0199 0.2003 0.2057
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.1236 0.6117
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0663 0.0652
Brugia malayi nuclear receptor RXR 0.0171 0.1694 0.1738
Brugia malayi conserved hypotetical protein 0.0153 0.1494 0.1531
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.007 0.0593 0.9222
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.007 0.0052
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0855 0.0871
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0036 0.0216 0.1574
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0184 0.1839 0.187
Entamoeba histolytica hypothetical protein 0.0199 0.2003 1
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0118 0.1498
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0153 0.1494 0.2521
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0032 0.0182 0.0268
Echinococcus multilocularis geminin 0.0553 0.5852 0.5841
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0035 0.0211 0.2285
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0036 0.0216 0.0963
Brugia malayi isocitrate dehydrogenase 0.0035 0.0211 0.0206
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0036 0.0216 0.0673
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0855 0.1424
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0259
Leishmania major cytochrome p450-like protein 0.0036 0.0216 0.1574
Schistosoma mansoni Smad4 0.0027 0.0122 0.0165
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.1121 0.3872
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0536 0.2577
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0041 0.0275 0.0296
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.007 0.0059
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0036 0.0216 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0324 0.3359 0.3458
Onchocerca volvulus Huntingtin homolog 0.0139 0.1341 0.1399
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0663 0.0672
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0035 0.0211 0.5015
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0324 0.3359 0.3458
Echinococcus multilocularis musashi 0.009 0.0807 0.0783
Schistosoma mansoni regulator of G protein signaling 0.0022 0.007 0.0076
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0043 0.0301 0.0473
Mycobacterium ulcerans hypothetical protein 0.0043 0.0303 0.1402
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0065 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0036 0.0216 0.3096
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0026 0.0118 0.0326
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0396 0.0635
Brugia malayi nuclear hormone receptor 0.0324 0.3359 0.3458
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0036 0.0216 0.0963
Loa Loa (eye worm) hypothetical protein 0.0094 0.0855 0.0851
Loa Loa (eye worm) Smad1 0.0027 0.0122 0.0092
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0041 0.0275 0.3
Schistosoma mansoni survival motor neuron protein 0.0104 0.0966 0.1613
Loa Loa (eye worm) cytochrome P450 family protein 0.012 0.1137 0.1143
Brugia malayi nuclear hormone receptor 0.0153 0.1494 0.1531
Schistosoma mansoni alpha glucosidase 0.0041 0.0275 0.0429
Onchocerca volvulus 0.007 0.0593 0.0496
Onchocerca volvulus 0.0793 0.8466 1
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0036 0.0216 0.0963
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.007 0.0593 0.0673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0303 0.0279
Brugia malayi nuclear hormone receptor family member odr-7 0.0153 0.1494 0.1531
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.009 0.0807 0.0801
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0303 0.0476
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.007 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0324 0.3359 0.3458
Mycobacterium ulcerans beta-lactamase 0.0043 0.0303 0.1402
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.007 0.0052
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0166 0.1635 0.1614
Onchocerca volvulus Protein ultraspiracle homolog 0.0324 0.3359 0.3835
Schistosoma mansoni coup transcription factor 0.0324 0.3359 0.5721
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Echinococcus granulosus neutral alpha glucosidase AB 0.0041 0.0275 0.0429
Brugia malayi hypothetical protein 0.0905 0.969 1
Brugia malayi Pre-SET motif family protein 0.0696 0.7415 0.7649
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0036 0.0216 0.0963
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0324 0.3359 0.3444
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.007 0.0044
Leishmania major alpha glucosidase II subunit, putative 0.0041 0.0275 0.2063
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0324 0.3359 0.3458
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0199 0.2003 0.3394
Loa Loa (eye worm) RNA binding protein 0.0076 0.0663 0.0652
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0071 0.0162
Mycobacterium tuberculosis Conserved protein 0.0043 0.0303 0.098
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0593 0.9222
Onchocerca volvulus 0.0153 0.1494 0.1584
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0303 0.098
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.1408 0.1386
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0303 0.0329
Echinococcus granulosus muscleblind protein 0.0164 0.1619 0.2735
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.007 0.0076
Trichomonas vaginalis set domain proteins, putative 0.0792 0.8463 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0085 0.007
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0035 0.0211 0.3017
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0065 0.4293
Trypanosoma brucei trypanothione reductase 0.0052 0.0396 0.6015
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0641 0.0629
Brugia malayi follicle stimulating hormone receptor 0.0269 0.2764 0.2843
Onchocerca volvulus Huntingtin homolog 0.0139 0.1341 0.1399
Leishmania major cytochrome p450-like protein 0.0036 0.0216 0.1574
Loa Loa (eye worm) intermediate filament protein 0.009 0.0807 0.0801
Echinococcus granulosus nuclear receptor nhr 48 0.0153 0.1494 0.2521
Schistosoma mansoni hypothetical protein 0.0553 0.5852 1
Onchocerca volvulus 0.0107 0.0992 0.0978
Echinococcus multilocularis transfer RNA-Lys 0.02 0.2005 0.1984
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0211 0.3017
Toxoplasma gondii exonuclease III APE 0.0022 0.0065 0.0709
Brugia malayi cytoplasmic intermediate filament protein 0.0048 0.0353 0.0352
Plasmodium falciparum thioredoxin reductase 0.0052 0.0396 1
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0065 0.0643
Loa Loa (eye worm) hypothetical protein 0.0043 0.0301 0.0277
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0065 0.1069
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0303 0.0279
Echinococcus granulosus aryl hydrocarbon receptor 0.007 0.0593 0.0974
Brugia malayi bHLH-PAS transcription factor 0.02 0.2005 0.2059
Echinococcus multilocularis isocitrate dehydrogenase 0.0035 0.0211 0.0186
Schistosoma mansoni nuclear hormone receptor 0.0324 0.3359 0.5721
Loa Loa (eye worm) hypothetical protein 0.0635 0.675 0.6955
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0122 0.0092
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0036 0.0216 0.0963
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0593 0.9222
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0071 0.0743
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0035 0.0211 0.0656
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.0536 0.0511
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0025 0.0278
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0026 0.0118 0.1624
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0036 0.0216 0.0963
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.007 0.0076
Onchocerca volvulus 0.009 0.0807 0.0754
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0593 0.0673
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0036 0.0216 0.0673
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0022 0.007 0.0076
Schistosoma mansoni zinc finger protein 0.0153 0.1494 0.2521
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0303 0.098
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Leishmania major protein kinase, putative 0.007 0.0593 0.4689
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0303 0.4509
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0324 0.3359 0.5721
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.01 0.0917 0.0894
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0324 0.3359 0.3458
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0296
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.1236 0.2078
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0129 0.1236 0.1214
Echinococcus granulosus single minded 2 0.02 0.2005 0.3397
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0118 0.1263
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0122 0.0165
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.007 0.0593 0.0673
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.0139 0.1341 0.1354
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0855 0.1424
Brugia malayi Pre-SET motif family protein 0.01 0.0917 0.0935
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0303 0.098
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0396 0.0375
Echinococcus granulosus lysosomal alpha glucosidase 0.0184 0.1839 0.3113
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0324 0.3359 0.5721
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0206 0.0181
Schistosoma mansoni smad 0.0027 0.0122 0.0165
Onchocerca volvulus 0.009 0.0807 0.0754
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0129 0.1236 0.6117
Schistosoma mansoni nuclear hormone receptor 0.0153 0.1494 0.2521
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0153 0.1494 0.1531
Echinococcus granulosus death domain containing protein 0.0032 0.0182 0.0268
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0038
Echinococcus granulosus regulator of G protein signaling 3 0.0022 0.007 0.0076
Brugia malayi Cytochrome P450 family protein 0.012 0.1137 0.1162
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0324 0.3359 0.3458
Leishmania major phosphopantetheinyl transferase-like protein 0.0026 0.0118 0.0761
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0036 0.0216 0.0963
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0048 0.0353 0.0331
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.1408 0.2373
Echinococcus granulosus axis inhibition protein axin 0.0022 0.007 0.0076
Brugia malayi hypothetical protein 0.0139 0.1341 0.1373
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0644 0.0653
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0303 0.1614
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0186
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0035 0.0211 0.3017
Echinococcus granulosus neuropeptide receptor A26 0.0534 0.5649 0.9653
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0043 0.0301 0.0276
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0026 0.0118 0.1283
Trichomonas vaginalis guanylate cyclase, putative 0.007 0.0593 0.0673
Leishmania major trypanothione reductase 0.0052 0.0396 0.3058
Brugia malayi PXA domain containing protein 0.0022 0.007 0.0059
Brugia malayi small heat shock protein 0.0635 0.675 0.6962
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0025 0.0014
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0396 0.6015
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.007 0.0593 0.9222
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0038
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0324 0.3359 0.3342
Brugia malayi MH2 domain containing protein 0.0394 0.4121 0.4246
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Echinococcus granulosus ecdysone induced protein 78C 0.0324 0.3359 0.5721
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.007 0.0593 0.9222
Toxoplasma gondii cytochrome p450 superfamily protein 0.0036 0.0216 0.2355
Brugia malayi tailless protein 0.0153 0.1494 0.1531
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0041 0.0275 0.1084
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0303 0.1402
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0071 0.0054
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.007 0.0593 0.058
Loa Loa (eye worm) hypoxia-induced factor 1 0.0835 0.8926 0.9209
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.1266 0.4381
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0036 0.0216 0.0673
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0275 0.4057
Echinococcus multilocularis regulator of G protein signaling 0.0022 0.007 0.0044
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Loa Loa (eye worm) hypothetical protein 0.01 0.0917 0.0916
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0022 0.007 0.0059
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0303 0.0278
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1839 0.1818
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0026 0.0118 0.0466
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0071 0.0039
Onchocerca volvulus Bile acid receptor homolog 0.0324 0.3359 0.3835
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0036 0.0216 0.0963
Brugia malayi nuclear receptor NHR-88 0.0324 0.3359 0.3458
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.1121 0.3872
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0032 0.0182 0.0157
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0153 0.1494 0.1513
Entamoeba histolytica hypothetical protein 0.0022 0.007 0.0023
Trypanosoma brucei cytochrome P450, putative 0.0074 0.0641 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0324 0.3359 0.3458
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0031 0.001
Onchocerca volvulus 0.0113 0.106 0.106
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0324 0.3359 0.3458
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0206 0.0181
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0071 0.0743
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0129 0.1236 0.4276
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.007 0.0052
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0171 0.1694 0.2864
Brugia malayi ecdysone receptor 0.0153 0.1494 0.1531
Brugia malayi Nuclear hormone receptor-like 1 0.0324 0.3359 0.3458
Echinococcus multilocularis aryl hydrocarbon receptor 0.007 0.0593 0.0569
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0054 0.0764
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0085 0.007
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0065 0.0047
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0171 0.1694 0.2864
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.007 0.0044
Schistosoma mansoni regulator of G protein signaling 0.0022 0.007 0.0076
Onchocerca volvulus 0.0043 0.0303 0.0146
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.1266 0.4381
Schistosoma mansoni z-protein (S1r protein) 0.0022 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Onchocerca volvulus 0.0324 0.3359 0.3835
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0536 0.2577
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0663 0.1094
Echinococcus multilocularis beta adrenergic receptor kinase 0.0022 0.007 0.0044
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.2856 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0324 0.3359 0.5721
Loa Loa (eye worm) hypothetical protein 0.0043 0.0303 0.0279
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0536 0.0876
Leishmania major hypothetical protein, conserved 0.0043 0.0303 0.2292
Entamoeba histolytica hypothetical protein 0.0199 0.2003 1
Onchocerca volvulus 0.0043 0.0303 0.0146
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.007 0.0593 0.0974
Echinococcus granulosus GPCR family 2 0.0035 0.0206 0.031
Loa Loa (eye worm) hypothetical protein 0.0033 0.0185 0.0157
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0122 0.0096
Entamoeba histolytica hypothetical protein 0.0199 0.2003 1
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.007 0.0593 0.0569
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0324 0.3359 0.5721
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0303 0.03
Echinococcus multilocularis muscleblind protein 1 0.0164 0.1619 0.1597
Loa Loa (eye worm) hypothetical protein 0.0088 0.0789 0.0782
Mycobacterium leprae Probable lipase LipE 0.0043 0.0303 0.1614
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.007 0.0076
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0324 0.3359 0.3342
Schistosoma mansoni hypothetical protein 0.0035 0.0206 0.031
Onchocerca volvulus 0.0104 0.0966 0.0946
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0036 0.0216 0.0673
Brugia malayi hypothetical protein 0.0153 0.1494 0.1531
Brugia malayi Nuclear hormone receptor-like 1 0.0171 0.1694 0.1738
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0324 0.3359 0.3444
Echinococcus granulosus Regulator of G protein signaling 20 0.0022 0.007 0.0076
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0035 0.0211 0.1534
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0324 0.3359 0.5721
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0303 0.098
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0036 0.0216 0.3096
Loa Loa (eye worm) hypothetical protein 0.0035 0.0206 0.0179
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0036 0.0216 0.0963
Leishmania major cytochrome p450-like protein 0.0074 0.0641 0.5084
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0171 0.1694 0.172
Schistosoma mansoni hypothetical protein 0.0199 0.2003 0.3394
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0022 0.007 0.0038
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.0536 0.1802
Brugia malayi Muscleblind-like protein 0.0164 0.1619 0.166
Brugia malayi MH1 domain containing protein 0.0027 0.0122 0.0113
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0026 0.0118 0.0466
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0071 0.0378
Brugia malayi Thioredoxin reductase 0.0052 0.0396 0.0396
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0065 0.0055
Loa Loa (eye worm) PXA domain-containing protein 0.0022 0.007 0.0038
Loa Loa (eye worm) isocitrate dehydrogenase 0.0035 0.0211 0.0184
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0026 0.0118 1
Schistosoma mansoni hypothetical protein 0.0035 0.0206 0.031
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0396 0.1308
Schistosoma mansoni nuclear receptor 0.0153 0.1494 0.2521
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.007 0.0593 0.0673
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0324 0.3359 0.3444
Loa Loa (eye worm) hypothetical protein 0.0171 0.1694 0.172
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0035 0.0211 0.0319
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Plasmodium falciparum glutathione reductase 0.0052 0.0396 1
Brugia malayi MH2 domain containing protein 0.0027 0.0122 0.0113
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0153 0.1494 0.1472
Brugia malayi Glycosyl hydrolases family 31 protein 0.0184 0.1839 0.1888
Echinococcus multilocularis Ankyrin 0.0033 0.0185 0.016
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0071 0.0054
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0296
Loa Loa (eye worm) glutathione reductase 0.0052 0.0396 0.0375
Echinococcus multilocularis expressed protein 0.043 0.4511 0.4497
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.1266 1
Onchocerca volvulus 0.0117 0.1099 0.1108
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0303 0.0329
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0036 0.0216 0.0963
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.007 0.0593 1
Loa Loa (eye worm) nuclear receptor NHR-67 0.0153 0.1494 0.1513
Schistosoma mansoni alpha-glucosidase 0.0159 0.1559 0.2633
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0071 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0917 0.1531
Brugia malayi Uncoordinated protein 44 0.0032 0.0182 0.0175
Loa Loa (eye worm) hypothetical protein 0.0139 0.1341 0.1354
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0103 0.0956 0.0933
Schistosoma mansoni smad1 5 8 and 0.0027 0.0122 0.0165
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0324 0.3359 0.3835
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0022 0.007 0.0052
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0269 0.2764 0.2828
Echinococcus multilocularis neuropeptide receptor A26 0.0534 0.5649 0.5638
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0303 0.098
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0036 0.0216 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.007 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0025 0.0256
Loa Loa (eye worm) RGS-3 protein 0.0022 0.007 0.0038
Brugia malayi hypothetical protein 0.0153 0.1494 0.1531
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0036 0.0216 0.0673
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0593 0.0673
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0071 0.0231
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0186
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0065 0.0033
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Loa Loa (eye worm) hypothetical protein 0.0042 0.0283 0.0259
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0324 0.3359 0.3342
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0036 0.0216 0.0673
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.012 0.1141 0.1148
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0296
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0324 0.3359 0.5721
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0065 0.4293
Echinococcus granulosus histone lysine methyltransferase setb 0.01 0.0917 0.1531
Mycobacterium ulcerans lipase LipD 0.0043 0.0303 0.1402
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0663 0.1094
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0396 0.4301
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0036 0.0216 0.0963
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0036 0.0216 0.0673
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0303 0.1402
Onchocerca volvulus 0.0174 0.1724 0.1862
Schistosoma mansoni transcription factor LCR-F1 0.0199 0.2003 0.3394
Loa Loa (eye worm) hypothetical protein 0.0349 0.363 0.3725
Brugia malayi nuclear hormone receptor family member nhr-6 0.0153 0.1494 0.1531
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0041 0.0275 0.0251
Onchocerca volvulus 0.0153 0.1494 0.1584
Entamoeba histolytica hypothetical protein 0.0026 0.0118 0.0271
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0206 0.02
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0206 0.031
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0025 0.0278
Loa Loa (eye worm) steroid hormone receptor 0.0324 0.3359 0.3444
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.0043 0.0303 0.0279
Loa Loa (eye worm) nuclear hormone receptor 0.0153 0.1494 0.1513
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0129 0.1236 0.2078
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0206 0.031
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.007 0.0052
Schistosoma mansoni lamin 0.009 0.0807 0.1341
Brugia malayi Cytochrome P450 family protein 0.0074 0.0641 0.065
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.1021 0.1042
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.1021 0.1023
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0071 0.0743
Brugia malayi Immunoglobulin I-set domain containing protein 0.0032 0.0182 0.0175
Entamoeba histolytica hypothetical protein 0.0022 0.007 0.0023
Echinococcus multilocularis ecdysone induced protein 78C 0.0324 0.3359 0.3342
Echinococcus granulosus bloom syndrome protein 0.0023 0.0085 0.0102
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0022 0.007 0.0038
Leishmania major DNA polymerase kappa, putative 0.0022 0.0071 0.0378
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0065 0.0643
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0206 0.0179
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0036 0.0216 0.0673
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0324 0.3359 0.3342
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0324 0.3359 0.3444
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Brugia malayi Nuclear hormone receptor E75 0.0153 0.1494 0.1531
Toxoplasma gondii thioredoxin reductase 0.0052 0.0396 0.4314
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0038
Echinococcus granulosus geminin 0.0553 0.5852 1
Echinococcus multilocularis FTZ F1 alpha 0.0324 0.3359 0.3342
Brugia malayi nuclear receptor NHR-67 0.0153 0.1494 0.1531
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0103 0.0956 0.1598
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Brugia malayi hypothetical protein 0.0022 0.007 0.0059
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0324 0.3359 0.5721
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0324 0.3359 0.5721
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0153 0.1494 0.2521
Schistosoma mansoni ap endonuclease 0.0022 0.0065 0.0068
Brugia malayi regulator of G-protein signaling rgs-7 0.0022 0.007 0.0059
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0153 0.1494 0.2521
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0065 0.8651
Schistosoma mansoni cytochrome P450 0.0036 0.0216 0.0327
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.01 0.0917 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0917 0.1531
Plasmodium vivax glutathione reductase, putative 0.0052 0.0396 0.4301
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0324 0.3359 0.3458
Schistosoma mansoni regulator of G protein signaling 0.0022 0.007 0.0076
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0216 0.3096
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.0171 0.1694 0.172
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0022 0.007 0.0044
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0065 0.004
Echinococcus multilocularis GPCR, family 2 0.0035 0.0206 0.0181
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Brugia malayi beta-lactamase family protein 0.0043 0.0303 0.03
Echinococcus multilocularis nuclear receptor nhr 48 0.0153 0.1494 0.1472
Brugia malayi hypoxia-induced factor 1 0.0835 0.8926 0.9211
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0153 0.1494 0.1584
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0036 0.0216 0.0963
Brugia malayi nuclear receptor RXR 0.0153 0.1494 0.1531
Onchocerca volvulus 0.0043 0.0303 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0663 0.1094
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0085 0.0075
Schistosoma mansoni nuclear receptor 0.0153 0.1494 0.2521
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Brugia malayi PXA domain containing protein 0.0022 0.007 0.0059
Loa Loa (eye worm) hypothetical protein 0.009 0.0807 0.0801
Brugia malayi MH2 domain containing protein 0.0027 0.0122 0.0113
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0324 0.3359 0.3458
Loa Loa (eye worm) hypothetical protein 0.0171 0.1694 0.172
Brugia malayi hypothetical protein 0.0022 0.007 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.007 0.0593 0.058
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0324 0.3359 0.5721
Plasmodium vivax SET domain protein, putative 0.01 0.0917 1
Brugia malayi hypothetical protein 0.0134 0.1288 0.1318
Brugia malayi hypothetical protein 0.0174 0.1724 0.1769
Mycobacterium tuberculosis Conserved protein 0.0043 0.0303 0.098
Trichomonas vaginalis alpha-glucosidase, putative 0.0041 0.0275 0.0296
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0071 0.0046
Schistosoma mansoni hypothetical protein 0.0032 0.0182 0.0268
Brugia malayi Nuclear hormone receptor-like 1 0.0171 0.1694 0.1738
Echinococcus multilocularis survival motor neuron protein 1 0.0511 0.54 0.5389
Echinococcus multilocularis 0.0036 0.0216 0.0191
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0129 0.1236 1
Schistosoma mansoni thyroid hormone receptor 0.0469 0.4938 0.8432
Loa Loa (eye worm) hypothetical protein 0.0075 0.0644 0.0632
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0036 0.0216 0.0963
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0035 0.0211 0.0186
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0096 0.0877 0.1462
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0071 0.0061
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.007 0.0593 0.0673
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0303 0.0329
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0696 0.7415 0.7644
Echinococcus granulosus tar DNA binding protein 0.0076 0.0663 0.1094
Brugia malayi Death domain containing protein 0.0032 0.0182 0.0175
Loa Loa (eye worm) cytochrome P450 family protein 0.0074 0.0641 0.0629
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0641 1
Mycobacterium leprae Possible regulatory protein 0.007 0.0593 0.4141
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0071 0.0231
Schistosoma mansoni intermediate filament proteins 0.009 0.0807 0.1341
Schistosoma mansoni ankyrin 23/unc44 0.0032 0.0182 0.0268
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0036 0.0216 0.0963
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0206 0.02
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0071 0.0743
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.0536 0.4214
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0025 0.0256
Schistosoma mansoni retinoic acid receptor RXR 0.0324 0.3359 0.5721
Brugia malayi Intermediate filament tail domain containing protein 0.009 0.0807 0.0821
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0303 0.0329
Brugia malayi hypothetical protein 0.0511 0.54 0.5567
Loa Loa (eye worm) hypothetical protein 0.0039 0.0254 0.0229
Brugia malayi Regulator of G protein signaling domain containing protein 0.0022 0.007 0.0059
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.01 0.0917 0.1531
Loa Loa (eye worm) hypothetical protein 0.0022 0.0071 0.0039
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0153 0.1494 0.1472
Brugia malayi orphan nuclear receptor NR2E1 0.0153 0.1494 0.1531
Echinococcus granulosus lamin 0.009 0.0807 0.1341
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0122 0.0165
Brugia malayi PAS domain containing protein 0.027 0.2768 0.2848
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0593 0.9222
Schistosoma mansoni hypothetical protein 0.0145 0.1408 0.2373
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0324 0.3359 0.3458
Loa Loa (eye worm) hypothetical protein 0.0022 0.007 0.0038
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0303 0.098
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.0536 0.2577
Echinococcus multilocularis smad 0.0027 0.0122 0.0096
Brugia malayi hypothetical protein 0.0117 0.1102 0.1127
Mycobacterium ulcerans putative regulatory protein 0.02 0.2005 1
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0036 0.0216 0.0673
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Loa Loa (eye worm) hypothetical protein 0.0164 0.1619 0.1642
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0153 0.1494 0.1472
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.0536 0.5839
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0855 0.0832
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0036 0.0216 0.3096
Schistosoma mansoni hypothetical protein 0.0104 0.0966 0.1613
Echinococcus granulosus thyroid hormone receptor alpha 0.0153 0.1494 0.2521
Schistosoma mansoni nuclear hormone receptor 0.0153 0.1494 0.2521
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0199 0.2003 0.1982
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0153 0.1494 0.1584
Loa Loa (eye worm) hypothetical protein 0.0117 0.1102 0.1107
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0663 0.1094
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.007 0.0593 0.0673
Brugia malayi A-kinase anchor protein 10, precursor 0.0022 0.007 0.0059
Schistosoma mansoni nuclear receptor nhr-48 0.0153 0.1494 0.2521
Loa Loa (eye worm) hypothetical protein 0.0511 0.54 0.5558
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0036 0.0216 0.0963
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.1121 0.3872
Schistosoma mansoni hypothetical protein 0.0035 0.0206 0.031
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0153 0.1494 0.1472
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.01 0.0917 0.0894
Loa Loa (eye worm) DR-78 0.0153 0.1494 0.1513
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0085 0.0059
Mycobacterium tuberculosis Conserved protein 0.0043 0.0303 0.098
Echinococcus multilocularis neuropeptide s receptor 0.0534 0.5649 0.5638
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0071 0.0079
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0026 0.0118 0.1283
Loa Loa (eye worm) hypothetical protein 0.0043 0.0303 0.0279
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0905 0.969 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0153 0.1494 0.1472
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0035 0.0211 0.0319
Trichomonas vaginalis sucrase-isomaltase, putative 0.0041 0.0275 0.0296
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0303 0.4509
Echinococcus granulosus regulator of G protein signaling 7 0.0022 0.007 0.0076
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0103 0.0956 0.1598
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0022 0.007 0.0038
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0211 0.2302
Schistosoma mansoni axis inhibition protein axin 0.0022 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0171 0.1694 0.172
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0275 0.4057
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.1121 0.8744
Mycobacterium leprae Conserved hypothetical protein 0.0036 0.0216 0.0857
Trichomonas vaginalis adenylate cyclase, putative 0.007 0.0593 0.0673
Brugia malayi Steroid receptor seven-up type 2 0.0324 0.3359 0.3458
Onchocerca volvulus 0.02 0.2005 0.22
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0065 0.014
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0663 0.1094
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0129 0.1236 0.1265
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0324 0.3359 0.5721
Echinococcus multilocularis regulator of G protein signaling 7 0.0022 0.007 0.0044
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.1266 0.4381
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.007 0.0052
Echinococcus granulosus neuropeptide s receptor 0.0534 0.5649 0.9653
Schistosoma mansoni aryl hydrocarbon receptor 0.027 0.2768 0.4708
Entamoeba histolytica hypothetical protein 0.0199 0.2003 1
Brugia malayi beta-lactamase family protein 0.0043 0.0303 0.03
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.007 0.0593 0.4689
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.007 0.0044
Leishmania major protein kinase, putative 0.007 0.0593 0.4689
Schistosoma mansoni hypothetical protein 0.0107 0.0991 0.1658
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0022 0.007 0.0076
Trypanosoma brucei glucosidase, putative 0.0041 0.0275 0.4057
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.1121 0.3872
Echinococcus multilocularis lysosomal alpha glucosidase 0.0184 0.1839 0.1818
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0324 0.3359 0.3458
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0324 0.3359 0.3444
Echinococcus multilocularis neutral alpha glucosidase AB 0.0041 0.0275 0.025
Schistosoma mansoni lamin 0.009 0.0807 0.1341
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0104 0.0966 0.0985
Toxoplasma gondii ABC1 family protein 0.0043 0.0303 0.3303
Echinococcus multilocularis axis inhibition protein axin 0.0022 0.007 0.0044
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0324 0.3359 0.5721
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0065 0.0068
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0324 0.3359 0.3458
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0036 0.0216 0.0963
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0103 0.0956 0.1598
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0036 0.0216 0.0963
Loa Loa (eye worm) beta-lactamase 0.0043 0.0303 0.0279
Echinococcus granulosus Nuclear hormone receptor HR96 0.0153 0.1494 0.2521
Echinococcus granulosus expressed protein 0.043 0.4511 0.7699
Brugia malayi RNA binding protein 0.0076 0.0663 0.0672
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0303 0.0329
Loa Loa (eye worm) hypothetical protein 0.0043 0.0303 0.0279
Brugia malayi TAR-binding protein 0.0076 0.0663 0.0672
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0324 0.3359 0.3458
Trypanosoma cruzi cytochrome P450, putative 0.0074 0.0641 1
Echinococcus granulosus FTZ F1 alpha 0.0324 0.3359 0.5721
Brugia malayi glutathione reductase 0.0052 0.0396 0.0396
Echinococcus granulosus nuclear factor of activated T cells 5 0.0166 0.1635 0.2763
Trichomonas vaginalis maltase-glucoamylase, putative 0.0041 0.0275 0.0296
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0122 0.0165
Brugia malayi Isocitrate dehydrogenase 0.0035 0.0211 0.0206
Brugia malayi hypothetical protein 0.0171 0.1694 0.1738
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0171 0.1694 0.2864
Schistosoma mansoni single-minded 0.027 0.2768 0.4708
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0071 0.0162
Trichomonas vaginalis esterase, putative 0.0043 0.0303 0.0329
Loa Loa (eye worm) hypothetical protein 0.0043 0.0303 0.0279
Schistosoma mansoni alpha-glucosidase 0.0159 0.1559 0.2633
Schistosoma mansoni hypothetical protein 0.0075 0.0644 0.1061
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0036 0.0216 0.0963
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0074 0.0641 0.311
Echinococcus granulosus Ankyrin 0.0033 0.0185 0.0273
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0324 0.3359 0.3444
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0065 0.0689
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0324 0.3359 0.5721
Schistosoma mansoni hypothetical protein 0.0036 0.0216 0.0327
Echinococcus granulosus axis inhibition protein axin 0.0022 0.007 0.0076
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0303 0.0476
Echinococcus granulosus lamin dm0 0.009 0.0807 0.1341
Echinococcus multilocularis netrin receptor unc 5 0.0032 0.0182 0.0157
Brugia malayi intermediate filament protein 0.009 0.0807 0.0821
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0071 0.0743
Onchocerca volvulus 0.0094 0.0855 0.0813
Toxoplasma gondii isocitrate dehydrogenase 0.0035 0.0211 0.2302
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0071 0.0032
Brugia malayi Cytochrome P450 family protein 0.0074 0.0641 0.065
Giardia lamblia DINP protein human, muc B family 0.0022 0.0071 1
Trichomonas vaginalis conserved hypothetical protein 0.007 0.0593 0.0673
Echinococcus granulosus cytochrome P450 2K1 0.0036 0.0216 0.0327
Mycobacterium tuberculosis Probable reductase 0.0119 0.1121 0.3872
Loa Loa (eye worm) hypothetical protein 0.0174 0.1724 0.1751
Loa Loa (eye worm) hypothetical protein 0.0109 0.1021 0.1023
Schistosoma mansoni netrin receptor unc5 0.0032 0.0182 0.0268
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.1021 0.1042
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0022 0.007 0.0076
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0303 0.4509
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0324 0.3359 0.3342
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0071 0.0061
Echinococcus multilocularis lamin dm0 0.009 0.0807 0.0783
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0036 0.0216 0.0673
Brugia malayi Cytochrome P450 family protein 0.0036 0.0216 0.0211
Echinococcus granulosus Smad4 0.0027 0.0122 0.0165
Schistosoma mansoni thyroid hormone receptor 0.0469 0.4938 0.8432
Echinococcus granulosus Nuclear hormone receptor HR96 0.0153 0.1494 0.2521
Loa Loa (eye worm) hypothetical protein 0.0171 0.1694 0.172
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0663 0.0639
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0324 0.3359 0.3342
Schistosoma mansoni steroid hormone receptor ad4bp 0.0324 0.3359 0.5721
Loa Loa (eye worm) CYP4Cod1 0.0074 0.0641 0.0629
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0071 0.0046
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.1121 0.3872
Schistosoma mansoni axis inhibition protein axin 0.0022 0.007 0.0076
Loa Loa (eye worm) cytochrome P450 0.0036 0.0216 0.0189
Echinococcus granulosus netrin receptor unc 5 0.0032 0.0182 0.0268
Loa Loa (eye worm) hypothetical protein 0.0164 0.1619 0.1642
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0032 0.0182 0.0154
Echinococcus granulosus survival motor neuron protein 1 0.0511 0.54 0.9225
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0153 0.1494 0.2521
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0026 0.0118 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0394 0.4121 0.4233
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0122 0.0096
Schistosoma mansoni DNA polymerase eta 0.0022 0.0071 0.0079
Brugia malayi M-phase phosphoprotein, mpp8 0.0117 0.1099 0.1123
Loa Loa (eye worm) RecQ helicase 0.0023 0.0085 0.0054
Schistosoma mansoni smad1 5 8 and 0.0027 0.0122 0.0165
Brugia malayi steroid hormone receptor 0.0324 0.3359 0.3458
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0026 0.0118 0.249
Brugia malayi Protein kinase domain containing protein 0.0032 0.0182 0.0175
Echinococcus multilocularis dna polymerase eta 0.0022 0.0071 0.0046
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0324 0.3359 0.3444
Leishmania major DNA polymerase eta, putative 0.0022 0.0071 0.0378
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.0536 0.0876
Echinococcus granulosus intermediate filament protein 0.009 0.0807 0.1341
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0071 0.0079
Echinococcus granulosus smad 0.0027 0.0122 0.0165
Echinococcus multilocularis muscleblind protein 0.0164 0.1619 0.1597
Schistosoma mansoni hypothetical protein 0.0035 0.0206 0.031
Brugia malayi regulator of G-protein signaling egl-10 0.0022 0.007 0.0059
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0071 0.0743
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0303 0.0476
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0036 0.0216 0.0673
Loa Loa (eye worm) hypothetical protein 0.0153 0.1494 0.1513
Echinococcus granulosus dna polymerase eta 0.0022 0.0071 0.0079
Trichomonas vaginalis guanylate cyclase, putative 0.007 0.0593 0.0673
Brugia malayi nuclear receptor NHR-88 0.0153 0.1494 0.1531
Loa Loa (eye worm) hypothetical protein 0.0117 0.1099 0.1104
Entamoeba histolytica hypothetical protein 0.0022 0.007 0.0023
Schistosoma mansoni regulator of G protein signaling 0.0022 0.007 0.0076
Loa Loa (eye worm) hypothetical protein 0.0324 0.3359 0.3444
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0065 0.0327
Echinococcus multilocularis Smad4 0.0027 0.0122 0.0096
Loa Loa (eye worm) hypothetical protein 0.0032 0.0182 0.0154
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.0536 0.0876
Echinococcus multilocularis thyroid hormone receptor alpha 0.0469 0.4938 0.4925
Brugia malayi MH1 domain containing protein 0.0027 0.0122 0.0113
Schistosoma mansoni regulator of G protein signaling 0.0022 0.007 0.0076
Echinococcus multilocularis Regulator of G protein signaling 20 0.0022 0.007 0.0044
Echinococcus multilocularis regulator of G protein signaling 3 0.0022 0.007 0.0044
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0122 0.0092
Brugia malayi hypothetical protein 0.0171 0.1694 0.1738
Loa Loa (eye worm) transcription factor SMAD2 0.0394 0.4121 0.4233
Echinococcus granulosus dna polymerase kappa 0.0022 0.0071 0.0079
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0303 0.3288
Schistosoma mansoni smad1 5 8 and 0.0027 0.0122 0.0165
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0036 0.0216 0.0673
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0171 0.1694 0.1673
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0065 0.0643
Echinococcus granulosus beta-adrenergic receptor kinase 0.0022 0.007 0.0076
Schistosoma mansoni ap endonuclease 0.0022 0.0065 0.0068
Brugia malayi cytochrome P450 0.0036 0.0216 0.0211
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0324 0.3359 0.5721
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0663 0.0652
Mycobacterium leprae putative cytochrome p450 0.0036 0.0216 0.0857
Trypanosoma brucei unspecified product 0.0022 0.0071 0.0743
Schistosoma mansoni hypothetical protein 0.0553 0.5852 1

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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