Detailed information for compound 1418732

Basic information

Technical information
  • TDR Targets ID: 1418732
  • Name: 2-fluoro-N-(2-hydroxyethyl)-N-[(6-methoxy-2-o xo-1H-quinolin-3-yl)methyl]benzamide
  • MW: 370.374 | Formula: C20H19FN2O4
  • H donors: 2 H acceptors: 4 LogP: 2.51 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCCN(C(=O)c1ccccc1F)Cc1cc2cc(OC)ccc2nc1O
  • InChi: 1S/C20H19FN2O4/c1-27-15-6-7-18-13(11-15)10-14(19(25)22-18)12-23(8-9-24)20(26)16-4-2-3-5-17(16)21/h2-7,10-11,24H,8-9,12H2,1H3,(H,22,25)
  • InChiKey: LFIBUXVSJGVTAP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-fluoro-N-(2-hydroxyethyl)-N-[(2-keto-6-methoxy-1H-quinolin-3-yl)methyl]benzamide
  • ASN 05107445
  • 2-Fluoro-N-(2-hydroxy-ethyl)-N-(6-methoxy-2-oxo-1,2-dihydro-quinolin-3-ylmethyl)-benzamide
  • MLS000072945
  • SMR000004067
  • ZINC01366738
  • Oprea1_442628

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Bacillus subtilis (strain 168) ATP-dependent Clp protease proteolytic subunit Starlite/ChEMBL No references
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Probable ClpP-like protease Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus peptidase Clp S14 family Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Babesia bovis ATP-dependent Clp protease proteolytic subunit 1, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma japonicum ko:K01358 ATP-dependent Clp protease, protease subunit [EC3.4.21.92], putative Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Treponema pallidum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein Get druggable targets OG5_127187 All targets in OG5_127187
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Neospora caninum ATP-dependent Clp protease proteolytic subunit, related Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) Get druggable targets OG5_127187 All targets in OG5_127187
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus multilocularis peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Plasmodium yoelii ATP-dependent Clp protease, proteolytic subunit ClpP, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K06275 parvin, putative Get druggable targets OG5_127187 All targets in OG5_127187
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit Get druggable targets OG5_127187 All targets in OG5_127187
Theileria parva ATP-dependent Clp protease proteolytic subunit, putative Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma mansoni peptidase Clp (S14 family) Get druggable targets OG5_127187 All targets in OG5_127187
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127187 All targets in OG5_127187
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 35.5 %
Schistosoma mansoni neuropeptide receptor ATP-dependent Clp protease proteolytic subunit   197 aa 174 aa 20.1 %
Plasmodium knowlesi ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 189 aa 36.0 %
Onchocerca volvulus Putative V-type proton ATPase subunit F ATP-dependent Clp protease proteolytic subunit   197 aa 194 aa 54.1 %
Plasmodium yoelii Clp protease ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.6 %
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 ATP-dependent Clp protease proteolytic subunit   197 aa 172 aa 57.0 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 183 aa 36.1 %
Babesia bovis ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 188 aa 41.5 %
Treponema pallidum ATP-dependent Clp protease proteolytic subunit ATP-dependent Clp protease proteolytic subunit   197 aa 186 aa 40.3 %
Chlamydia trachomatis hypothetical protein ATP-dependent Clp protease proteolytic subunit   197 aa 171 aa 22.8 %
Plasmodium berghei ATP-dependent Clp protease proteolytic subunit, putative ATP-dependent Clp protease proteolytic subunit   197 aa 180 aa 36.7 %
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0204 0.0709 0.0779
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0086 0.028
Onchocerca volvulus 0.0031 0.0012 0.002
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0018 0.005
Onchocerca volvulus 0.0112 0.0337 0.1197
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.0124 0.0124
Echinococcus granulosus defective proboscis extension response 0.003 0.0007 0.0005
Onchocerca volvulus 0.0112 0.0337 0.1197
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0049 0.0084 0.0264
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0521 0.1756
Loa Loa (eye worm) hypothetical protein 0.0047 0.0077 0.0083
Loa Loa (eye worm) raf kinase 0.0031 0.0012 0.0011
Toxoplasma gondii AGC kinase 0.0044 0.0065 0.0471
Giardia lamblia Heat shock protein HSP 90-alpha 0.009 0.0251 0.243
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0061 0.0059
Brugia malayi jmjC domain containing protein 0.0029 0.0004 0.0002
Trypanosoma cruzi cysteine peptidase, putative 0.0053 0.0098 0.032
Echinococcus granulosus Immunoglobulin 0.003 0.0007 0.0005
Brugia malayi cathepsin L-like cysteine proteinase 0.0051 0.0092 0.01
Plasmodium falciparum serine repeat antigen 3 0.0051 0.0092 0.0697
Echinococcus granulosus lysine specific demethylase 6a 0.0029 0.0004 0.0002
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0228 0.0531
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.004 0.0048 0.0353
Brugia malayi RhoGAP domain containing protein 0.0031 0.0012 0.0011
Echinococcus granulosus Rac GTPase activating protein 1 0.0031 0.0012 0.001
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.025 0.025
Brugia malayi RNA binding protein 0.0063 0.014 0.0152
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.014 0.0152
Schistosoma mansoni hypothetical protein 0.0091 0.0253 0.0253
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0161 0.0538 0.0537
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Giardia lamblia Grp94/Hsp90 0.0085 0.0228 0.2195
Entamoeba histolytica transcription factor BTF3, putative 0.0035 0.0026 0.011
Echinococcus granulosus cathepsin b 0.0757 0.2949 0.2948
Echinococcus granulosus peptidase Clp S14 family 0.0062 0.0135 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0086 0.028
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0505 0.1928 0.2121
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.004 0.0083
Loa Loa (eye worm) matrix metalloproteinase 0.0035 0.0028 0.0029
Giardia lamblia Cysteine protease 0.0051 0.0092 0.0771
Echinococcus granulosus phd:f box containing protein 0.0029 0.0004 0.0002
Plasmodium falciparum serine repeat antigen 8 0.0051 0.0092 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 1
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0492 0.1876 0.2064
Brugia malayi heat shock protein 90 0.009 0.0251 0.0275
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0217 0.0763 0.2997
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.0305 0.1024
Echinococcus granulosus cathepsin l1 0.0059 0.0124 0.0122
Schistosoma mansoni unc-13 (munc13) 0.0031 0.0012 0.0012
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0031 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0757 0.2949 0.3245
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0252 0.0906 0.0905
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0033 0.0018 0.0018
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0061 0.0133
Echinococcus granulosus chromobox protein 1 0.0068 0.0161 0.016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0146 0.0159
Echinococcus granulosus chromobox protein 1 0.0068 0.0161 0.016
Trichomonas vaginalis set domain proteins, putative 0.0713 0.2769 0.6552
Giardia lamblia Cathepsin L precursor 0.0051 0.0092 0.0771
Onchocerca volvulus 0.0059 0.0124 0.0426
Trichomonas vaginalis esterase, putative 0.0043 0.0061 0.0133
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0047 0.0075 0.0073
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0085 0.0228 0.0852
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.2582 0.2581
Brugia malayi Probable ClpP-like protease 0.0094 0.0267 0.0292
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0077 0.0255
Loa Loa (eye worm) hypothetical protein 0.0156 0.0516 0.0566
Leishmania major basic transcription factor 3a, putative 0.0035 0.0026 0.0225
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0091 0.0205
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0085 0.0228 0.0846
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0018 0.005
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0053 0.0098 0.0106
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0044 0.0065 0.0063
Echinococcus multilocularis serine threonine protein kinase 0.0044 0.0065 0.0063
Echinococcus granulosus geminin 0.1368 0.542 0.5419
Brugia malayi Heterochromatin protein 1 0.0068 0.0161 0.0176
Brugia malayi TAR-binding protein 0.0063 0.014 0.0152
Brugia malayi Pre-SET motif family protein 0.0093 0.0262 0.0287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus granulosus cathepsin L 0.0104 0.0305 0.0304
Schistosoma mansoni hypothetical protein 0.0292 0.1067 0.1067
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0031 0.0012 0.001
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0061 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Schistosoma mansoni hypothetical protein 0.0064 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0064 0.0146 0.0159
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0092 0.01
Onchocerca volvulus Cathepsin L homolog 0.0051 0.0092 0.0311
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0052 0.0095 0.0213
Schistosoma mansoni cell polarity protein 0.0031 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0059 0.0124 0.0135
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Onchocerca volvulus 0.0713 0.2769 1
Echinococcus multilocularis partitioning defective protein 6 0.0031 0.0012 0.0011
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0061 0.0171
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0085 0.0228 0.8451
Schistosoma mansoni jumonji domain containing protein 0.0029 0.0004 0.0004
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0092 0.0092
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0112 0.0337 0.2627
Brugia malayi hypothetical protein 0.0296 0.1083 0.1191
Entamoeba histolytica hypothetical protein 0.0037 0.0035 0.0188
Schistosoma mansoni atypical protein kinase C 0.0535 0.2052 0.2052
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0051 0.0092 0.0207
Echinococcus multilocularis tar DNA binding protein 0.0063 0.014 0.0138
Loa Loa (eye worm) CXXC zinc finger family protein 0.0176 0.0595 0.0654
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.01
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0042 0.0249
Schistosoma mansoni tyrosine kinase 0.1205 0.4762 0.4762
Toxoplasma gondii cathepsin CPL 0.0112 0.0337 0.2578
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0092 0.0207
Loa Loa (eye worm) endoplasmin 0.009 0.0251 0.0275
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0032 0.0016 0.0014
Echinococcus multilocularis PHD finger protein rhinoceros 0.0091 0.0253 0.0251
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0092 0.0207
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0065 0.0063
Brugia malayi Immunoglobulin I-set domain containing protein 0.0505 0.1928 0.2121
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0033 0.0018 0.0018
Brugia malayi Cathepsin L-like precursor 0.0112 0.0337 0.0369
Onchocerca volvulus 0.0031 0.0012 0.002
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0084 0.0084
Giardia lamblia Cathepsin L precursor 0.0051 0.0092 0.0771
Echinococcus granulosus tumor protein p63 0.0336 0.1245 0.1243
Schistosoma mansoni tyrosine kinase 0.1224 0.4839 0.4839
Plasmodium falciparum cysteine proteinase falcipain 3 0.0112 0.0337 0.2627
Schistosoma mansoni protein kinase C mu 0.0031 0.0012 0.0012
Echinococcus granulosus insulin receptor 0.0731 0.2841 0.284
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0077 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.025 0.025
Echinococcus multilocularis protein kinase c epsilon type 0.0076 0.0192 0.019
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.027 0.0976 1
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0031 0.0012 0.0011
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0084 0.0091
Echinococcus multilocularis epidermal growth factor receptor 0.1224 0.4839 0.4838
Echinococcus granulosus zinc finger protein 0.0092 0.0257 0.0255
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.0709 0.0779
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0018 0.0017
Trichomonas vaginalis endoplasmin, putative 0.0066 0.0151 0.0346
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0049 0.0084 0.0264
Loa Loa (eye worm) AGC/AKT protein kinase 0.0044 0.0065 0.0069
Schistosoma mansoni cathepsin B (C01 family) 0.0051 0.0092 0.0092
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0757 0.2949 0.2949
Echinococcus multilocularis cysteine protease 0.0112 0.0337 0.0335
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0241 0.0861 0.3396
Treponema pallidum fructose-bisphosphate aldolase 0.014 0.0451 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.1072 0.4223 0.4648
Trichomonas vaginalis heat shock protein, putative 0.009 0.0251 0.0584
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0251 0.084
Giardia lamblia Cathepsin B precursor 0.0051 0.0092 0.0771
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0092 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Brugia malayi Cathepsin L-like cysteine proteinase 0.0059 0.0124 0.0135
Loa Loa (eye worm) RNA binding protein 0.0063 0.014 0.0152
Echinococcus granulosus epidermal growth factor receptor 0.2274 0.9084 0.9084
Echinococcus multilocularis jumonji domain containing protein 0.0127 0.0397 0.0396
Giardia lamblia Hypothetical protein 0.0051 0.0092 0.0771
Brugia malayi beta-lactamase family protein 0.0043 0.0061 0.0065
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.003 0.0007 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0004 0.0002
Brugia malayi Pleckstrin Homology Domain 0.0031 0.0012 0.0011
Schistosoma mansoni endoplasmin 0.009 0.0251 0.0251
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0005 0.0012
Brugia malayi Bromodomain containing protein 0.0157 0.0519 0.057
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0084 0.0091
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0051 0.0164
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0051 0.0092 0.01
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0061 0.0065
Plasmodium vivax heat shock protein, putative 0.0343 0.1272 1
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0083
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0092 0.0771
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0337 0.125 1
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0305 0.2369
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0051 0.0092 0.0697
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0451 0.3547
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Plasmodium falciparum heat shock protein 90 0.009 0.0251 0.1949
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0092 0.0207
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0061 0.0133
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0402 0.0402
Leishmania major hypothetical protein, conserved 0.0043 0.0061 0.0588
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.0709 0.0779
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0026 0.005
Echinococcus granulosus protein kinase C gamma type 0.0044 0.0065 0.0063
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Echinococcus multilocularis protein tyrosine kinase 0.0832 0.3253 0.3252
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0033 0.0018 0.0115
Echinococcus granulosus PHD finger protein rhinoceros 0.0091 0.0253 0.0251
Echinococcus granulosus twitchin 0.0039 0.0041 0.004
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0061 0.045
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0065
Echinococcus granulosus lysine specific demethylase 5A 0.0128 0.0402 0.04
Mycobacterium ulcerans hypothetical protein 0.0043 0.0061 0.0171
Mycobacterium tuberculosis Probable reductase 0.0217 0.0763 0.2997
Brugia malayi Bromodomain containing protein 0.0104 0.0306 0.0335
Mycobacterium tuberculosis Conserved protein 0.0043 0.0061 0.0171
Mycobacterium tuberculosis Conserved protein 0.0043 0.0061 0.0171
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0026 0.005
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Schistosoma mansoni heat shock protein 0.009 0.0251 0.0251
Giardia lamblia Encystation-specific protease 0.0051 0.0092 0.0771
Loa Loa (eye worm) hypothetical protein 0.0031 0.0009 0.0008
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0093 0.0262 0.026
Brugia malayi glutathione reductase 0.0095 0.027 0.0296
Schistosoma mansoni chromobox protein 0.0068 0.0161 0.0161
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.005
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.005
Giardia lamblia Cysteine protease 0.0051 0.0092 0.0771
Onchocerca volvulus 0.0035 0.0028 0.0079
Leishmania major cathepsin L-like protease 0.0112 0.0337 0.3428
Schistosoma mansoni jumonji domain containing protein 0.0237 0.0843 0.0843
Echinococcus granulosus Diacylglycerol kinase theta 0.0031 0.0012 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0051 0.0092 0.0697
Schistosoma mansoni tyrosine kinase 0.2274 0.9084 0.9084
Echinococcus granulosus raf serine:threonine protein kinase 0.005 0.0089 0.0087
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0267 0.2037
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0084 0.0824
Trichomonas vaginalis mercuric reductase, putative 0.0033 0.0018 0.0032
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.0092 0.01
Brugia malayi Ras association domain family 1 isoform A 0.0031 0.0012 0.0011
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0044 0.0065 0.0063
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0253 0.1928
Echinococcus multilocularis Immunoglobulin 0.003 0.0007 0.0005
Echinococcus granulosus GPCR family 2 0.0064 0.0146 0.0144
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0086 0.0639
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0065
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0092 0.01
Trichomonas vaginalis glutathione reductase, putative 0.0033 0.0018 0.0032
Loa Loa (eye worm) hypothetical protein 0.0043 0.0059 0.0064
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0104 0.0307 0.0307
Trypanosoma brucei ISWI complex protein 0.0061 0.0133 0.1326
Onchocerca volvulus 0.0112 0.0337 0.1197
Trichomonas vaginalis heat shock protein, putative 0.0085 0.0228 0.0531
Entamoeba histolytica cysteine protease, putative 0.0051 0.0092 0.0648
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.0305 0.0305
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0077 0.0077
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0018 0.0113
Schistosoma mansoni cathepsin C 0.0051 0.0092 0.0092
Toxoplasma gondii thioredoxin reductase 0.0095 0.027 0.206
Brugia malayi Protein kinase domain containing protein 0.0044 0.0065 0.0069
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0089 0.0089
Mycobacterium tuberculosis Probable oxidoreductase 0.0241 0.0861 0.3392
Echinococcus multilocularis neuroglian 0.0038 0.0038 0.0036
Brugia malayi Matrixin family protein 0.0035 0.0028 0.0029
Schistosoma mansoni protein phosphatase 2C 0.0029 0.0004 0.0004
Toxoplasma gondii heat shock protein 90, putative 0.009 0.0251 0.1913
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0192 0.0192
Schistosoma mansoni endoplasmin 0.009 0.0251 0.0251
Trypanosoma cruzi heat shock protein, putative 0.006 0.0128 0.0422
Brugia malayi hypothetical protein 0.005 0.0086 0.0093
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0086 0.0651
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0051 0.0092 0.0092
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0077 0.0195 0.0195
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0018 0.0116
Onchocerca volvulus Cathepsin L homolog 0.0112 0.0337 0.1197
Echinococcus multilocularis myotubularin protein 13 0.0031 0.0012 0.001
Schistosoma mansoni phosphatidylserine receptor 0.0029 0.0004 0.0004
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0031 0.0012 0.0012
Treponema pallidum NADH oxidase 0.0033 0.0018 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Schistosoma mansoni peptidase Clp (S14 family) 0.0094 0.0267 0.0267
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 0.2075
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0018 0.0151
Brugia malayi jmjC domain containing protein 0.0029 0.0004 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.1072 0.4223 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0018 0.0151
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0018 0.0116
Loa Loa (eye worm) histone methyltransferase 0.0058 0.0118 0.0128
Loa Loa (eye worm) TK/INSR protein kinase 0.0731 0.2841 0.3127
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0092 0.0092
Echinococcus multilocularis heat shock protein 90 0.0077 0.0198 0.0197
Loa Loa (eye worm) PAR-6 protein 0.0031 0.0012 0.0012
Toxoplasma gondii ABC1 family protein 0.0043 0.0061 0.0442
Loa Loa (eye worm) hypothetical protein 0.0161 0.0538 0.0591
Echinococcus multilocularis fetal alzheimer antigen, falz 0.01 0.029 0.0289
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0061 0.0171
Trypanosoma brucei PB1 domain containing protein, putative 0.0031 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0106
Trypanosoma cruzi trypanothione reductase, putative 0.0033 0.0018 0.005
Echinococcus multilocularis chromobox protein 1 0.0068 0.0161 0.016
Echinococcus multilocularis dnaJ subfamily B 0.25 1 1
Trypanosoma cruzi cysteine proteinase, putative 0.0104 0.0305 0.1024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Trypanosoma brucei heat shock protein 84, putative 0.006 0.0128 0.128
Loa Loa (eye worm) hypothetical protein 0.0154 0.0506 0.0556
Plasmodium vivax endoplasmin, putative 0.009 0.0251 0.1949
Entamoeba histolytica cysteine protease, putative 0.0051 0.0092 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Onchocerca volvulus 0.0032 0.0016 0.0035
Trichomonas vaginalis heat shock protein, putative 0.0077 0.0198 0.0458
Trypanosoma cruzi major cysteine proteinase, putative 0.0097 0.0276 0.0925
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0065 0.0065
Echinococcus multilocularis Diacylglycerol kinase theta 0.0031 0.0012 0.001
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0058 0.0118 0.0116
Schistosoma mansoni tyrosine kinase 0.1205 0.4762 0.4762
Giardia lamblia Cathepsin B precursor 0.0051 0.0092 0.0771
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0026 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0065 0.0065
Entamoeba histolytica cysteine protease, putative 0.0051 0.0092 0.0648
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.0709 0.0779
Echinococcus granulosus cathepsin b 0.0757 0.2949 0.2948
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0077 0.0083
Trypanosoma brucei cysteine peptidase C (CPC) 0.027 0.0976 1
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.01
Brugia malayi cathepsin F-like cysteine proteinase 0.0051 0.0092 0.01
Echinococcus multilocularis endoplasmin 0.0085 0.0228 0.0227
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0217 0.0763 0.2997
Brugia malayi p70 ribosomal S6 kinase beta 0.0044 0.0065 0.0069
Schistosoma mansoni zinc finger protein 0.0061 0.0133 0.0133
Leishmania major cysteine peptidase A (CPA) 0.0112 0.0337 0.3428
Brugia malayi Matrixin family protein 0.0035 0.0028 0.0029
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0033 0.0016 0.0028
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0068 0.0161 0.0159
Leishmania major hypothetical protein, conserved 0.0031 0.0012 0.0086
Loa Loa (eye worm) hypothetical protein 0.0094 0.0267 0.0292
Entamoeba histolytica cysteine protease, putative 0.0051 0.0092 0.0648
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0033 0.0018 0.0115
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0029
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0032 0.0016 0.0014
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Plasmodium falciparum endoplasmin, putative 0.0066 0.0151 0.1158
Onchocerca volvulus 0.0043 0.0061 0.0197
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0106
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0061 0.0171
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0051 0.0092 0.0648
Brugia malayi Cathepsin L-like precursor 0.0112 0.0337 0.0369
Loa Loa (eye worm) hypothetical protein 0.0112 0.0337 0.0369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0124 0.0283
Plasmodium falciparum serine repeat antigen 2 0.0051 0.0092 0.0697
Echinococcus multilocularis JmjC domain containing protein 4 0.0029 0.0004 0.0002
Echinococcus multilocularis muscleblind protein 0.0149 0.0486 0.0485
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0092 0.0207
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Brugia malayi acetyltransferase, GNAT family protein 0.0154 0.0506 0.0556
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0305 0.0712
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.01
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0061 0.0171
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0103 0.0102
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0049 0.0084 0.0264
Schistosoma mansoni tar DNA-binding protein 0.0063 0.014 0.014
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0051 0.0111
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0104 0.0305 0.0712
Plasmodium vivax unspecified product 0.0104 0.0305 0.2376
Schistosoma mansoni phd/f-box containing protein 0.0029 0.0004 0.0004
Echinococcus granulosus cpg binding protein 0.0193 0.0666 0.0665
Echinococcus granulosus mixed lineage leukemia protein mll 0.0047 0.0075 0.0073
Plasmodium vivax vivapain-2 0.0112 0.0337 0.2627
Echinococcus multilocularis epidermal growth factor receptor 0.2274 0.9084 0.9084
Plasmodium falciparum serine repeat antigen 5 0.0051 0.0092 0.0697
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0044 0.0065 0.0063
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.0305 0.0334
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0241 0.0861 0.3392
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.0092 0.0697
Onchocerca volvulus 0.0176 0.0595 0.2131
Onchocerca volvulus Glucosylceramidase homolog 0.0703 0.2731 0.9865
Echinococcus multilocularis zinc finger protein 0.0092 0.0257 0.0255
Loa Loa (eye worm) TK/EGFR protein kinase 0.2274 0.9084 1
Giardia lamblia PHD finger protein 15 0.0091 0.0253 0.2451
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0051 0.0092 0.0697
Plasmodium falciparum serine repeat antigen 6 0.0051 0.0092 0.0697
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0161 0.0538 0.0537
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0086 0.085
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0305 0.2369
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0092 0.0207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0043 0.0059 0.0064
Plasmodium vivax acyl-CoA synthetase, putative 0.0037 0.0033 0.0235
Giardia lamblia Cysteine protease 0.0051 0.0092 0.0771
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.025 0.0274
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0262 0.0262
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0731 0.2841 0.284
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 0.1001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus granulosus cathepsin L cysteine proteinase 0.0112 0.0337 0.0335
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0077 0.0075
Plasmodium falciparum serine repeat antigen 4 0.0051 0.0092 0.0697
Loa Loa (eye worm) ICD-1 protein 0.0035 0.0026 0.0026
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.015
Giardia lamblia Cathepsin B precursor 0.027 0.0976 1
Onchocerca volvulus 0.0112 0.0337 0.1197
Trypanosoma brucei transcription factor BTF3, putative 0.0035 0.0026 0.0225
Onchocerca volvulus 0.0031 0.0012 0.0021
Trypanosoma brucei heat shock protein 90, putative 0.009 0.0251 0.2544
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0112 0.0337 0.2627
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0012
Brugia malayi chromobox protein homolog 3 0.0038 0.004 0.0042
Giardia lamblia Cathepsin B precursor 0.027 0.0976 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0044 0.0065 0.0069
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Trichomonas vaginalis glucosylceramidase, putative 0.1072 0.4223 1
Schistosoma mansoni cell adhesion molecule 0.004 0.0046 0.0046
Onchocerca volvulus Cathepsin F homolog 0.0112 0.0337 0.1197
Loa Loa (eye worm) hypothetical protein 0.0149 0.0486 0.0533
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0084 0.0824
Brugia malayi jmjC domain containing protein 0.0029 0.0004 0.0002
Trypanosoma cruzi heat shock protein 90, putative 0.0038 0.0038 0.0117
Trypanosoma brucei trypanothione reductase 0.0095 0.027 0.2739
Brugia malayi cathepsin L-like precursor 0.0059 0.0124 0.0135
Trypanosoma cruzi PB1 domain containing protein, putative 0.0031 0.0012 0.0029
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0033 0.0016 0.0101
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0084 0.0271
Schistosoma mansoni diacylglycerol kinase theta 0.0031 0.0012 0.0012
Echinococcus multilocularis cathepsin L cysteine protease 0.0112 0.0337 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0192 0.0192
Echinococcus granulosus jumonji domain containing 1A 0.0029 0.0004 0.0002
Giardia lamblia Cathepsin B precursor 0.0051 0.0092 0.0771
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0092 0.0207
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Brugia malayi hypothetical protein 0.003 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0741 0.2885 0.6827
Trichomonas vaginalis glucosylceramidase, putative 0.1072 0.4223 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0298 0.109 0.1089
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.0124 0.0283
Brugia malayi diacylglycerol kinase 0.0031 0.0012 0.0011
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0031 0.0012 0.0011
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0018 0.0017
Echinococcus granulosus transcription factor btf3 0.0035 0.0026 0.0024
Schistosoma mansoni cathepsin S (C01 family) 0.0051 0.0092 0.0092
Brugia malayi Protein kinase domain containing protein 0.0044 0.0065 0.0069
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Trypanosoma cruzi PB1 domain containing protein, putative 0.0031 0.0012 0.0029
Onchocerca volvulus 0.0112 0.0337 0.1197
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0092 0.03
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0062 0.0135 0.0478
Loa Loa (eye worm) glutathione reductase 0.0095 0.027 0.0296
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0049 0.0084 0.0264
Echinococcus multilocularis protein TFG 0.0031 0.0012 0.0011
Loa Loa (eye worm) thioredoxin reductase 0.0095 0.027 0.0296
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0049 0.0084 0.0264
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0051 0.0091 0.0205
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.027 0.0976 0.2302
Trypanosoma cruzi cysteine protease, putative 0.0104 0.0305 0.1024
Entamoeba histolytica heat shock protein 90, putative 0.009 0.0251 0.1931
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0065
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0112 0.0337 0.0335
Echinococcus granulosus methyl CpG binding domain protein 2 0.0068 0.0161 0.0159
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0076 0.0192 0.0209
Schistosoma mansoni diacylglycerol kinase theta 0.0031 0.0012 0.0012
Echinococcus granulosus peregrin 0.0104 0.0306 0.0304
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0051 0.0092 0.0697
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.025 0.0249
Brugia malayi C1-like domain containing protein 0.0032 0.0016 0.0016
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0005 0.0015
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0033 0.0016 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0084 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus multilocularis unc 13 (munc13) 0.0031 0.0012 0.001
Plasmodium vivax thioredoxin reductase, putative 0.0095 0.027 0.2099
Onchocerca volvulus 0.0112 0.0337 0.1197
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0035 0.0034
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0058 0.0118 0.0116
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0094 0.0267 0.0266
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0103 0.0102
Schistosoma mansoni cathepsin s 0.0053 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Giardia lamblia Cathepsin L-like protease 0.0051 0.0092 0.0771
Toxoplasma gondii hypothetical protein 0.0033 0.0016 0.0099
Leishmania major hypothetical protein, conserved 0.005 0.0086 0.085
Giardia lamblia Cathepsin L-like protease 0.0051 0.0092 0.0771
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0032 0.0016 0.0016
Schistosoma mansoni hypothetical protein 0.0061 0.0133 0.0133
Schistosoma mansoni hypothetical protein 0.003 0.0005 0.0005
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0033 0.0018 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0092 0.0207
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0103 0.0112
Brugia malayi hypothetical protein 0.0037 0.0035 0.0037
Leishmania major cathepsin L-like protease 0.0157 0.0521 0.532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0047 0.0075 0.0074
Echinococcus granulosus protein kinase c eta type 0.0031 0.0012 0.001
Plasmodium vivax unspecified product 0.0051 0.0092 0.0697
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0052 0.0095 0.0704
Echinococcus granulosus JmjC domain containing protein 4 0.0029 0.0004 0.0002
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Schistosoma mansoni rac gtpase activating protein 0.0031 0.0012 0.0012
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.025 0.025
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0051 0.0092 0.0697
Schistosoma mansoni vav2 0.0031 0.0012 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0305 0.3102
Plasmodium falciparum glutathione reductase 0.0095 0.027 0.2099
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.006 0.0128 0.0441
Mycobacterium ulcerans lipase LipD 0.0043 0.0061 0.0171
Brugia malayi Thioredoxin reductase 0.0095 0.027 0.0296
Brugia malayi Endoplasmin precursor 0.009 0.0251 0.0275
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0051 0.0092 0.01
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0018 0.0017
Brugia malayi cathepsin F-like cysteine proteinase 0.0053 0.0098 0.0106
Plasmodium falciparum serine repeat antigen 1 0.0051 0.0092 0.0697
Brugia malayi cathepsin B-like cysteine proteinase 0.0757 0.2949 0.3245
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0029 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0048 0.0077 0.0083
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Schistosoma mansoni jumonji/arid domain-containing protein 0.0128 0.0402 0.0402
Onchocerca volvulus 0.0049 0.0084 0.0281
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0051 0.0092 0.0207
Brugia malayi Partitioning defective-6 homolog alpha 0.0031 0.0012 0.0012
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Giardia lamblia Cathepsin B precursor 0.0051 0.0092 0.0771
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0086 0.0651
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.015
Echinococcus multilocularis cathepsin L cysteine protease 0.0112 0.0337 0.0335
Schistosoma mansoni tyrosine kinase 0.0731 0.2841 0.2841
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0049 0.0084 0.0264
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0104 0.0305 0.1024
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0029
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0084 0.0225 0.0225
Loa Loa (eye worm) cathepsin B 0.027 0.0976 0.1073
Onchocerca volvulus Protein TFG homolog 0.0031 0.0012 0.0021
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0035
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0061 0.0588
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0051 0.0092 0.0697
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0051 0.0092 0.0207
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.006 0.0128 0.0127
Brugia malayi Protein kinase domain containing protein 0.0032 0.0016 0.0016
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0077 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0092 0.0207
Brugia malayi Papain family cysteine protease containing protein 0.0112 0.0337 0.0369
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.025 0.0249
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Brugia malayi Hemopexin family protein 0.005 0.0088 0.0095
Echinococcus multilocularis GPCR, family 2 0.0064 0.0146 0.0144
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0061 0.0061
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0452 0.045
Echinococcus multilocularis jumonji domain containing 1A 0.0029 0.0004 0.0002
Echinococcus granulosus protein TFG 0.0031 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Loa Loa (eye worm) acetyltransferase 0.0154 0.0506 0.0556
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Trypanosoma cruzi ISWI complex protein 0.0061 0.0133 0.0438
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0103 0.0103
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0094 0.0267 0.1007
Toxoplasma gondii NADPH-glutathione reductase 0.0033 0.0018 0.0113
Giardia lamblia Cathepsin B precursor 0.0051 0.0092 0.0771
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.0124 0.0904
Echinococcus granulosus microtubule associated protein 2 0.0667 0.2582 0.2581
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0091 0.0253 0.0253
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0091 0.0205
Schistosoma mansoni cpg binding protein 0.0176 0.0595 0.0595
Schistosoma mansoni zinc finger protein 0.0092 0.0257 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0063 0.014 0.014
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.004 0.0121
Trichomonas vaginalis glucosylceramidase, putative 0.1072 0.4223 1
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0305 0.2369
Leishmania major cathepsin L-like protease 0.0112 0.0337 0.3428
Onchocerca volvulus 0.0043 0.0061 0.0197
Echinococcus multilocularis geminin 0.1368 0.542 0.5419
Echinococcus granulosus myotubularin protein 13 0.0031 0.0012 0.001
Loa Loa (eye worm) ctsf protein 0.0112 0.0337 0.0369
Loa Loa (eye worm) AGC/NDR protein kinase 0.0044 0.0065 0.0069
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0092 0.01
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.01
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0538 0.0538
Trypanosoma cruzi heat shock protein 90, putative 0.009 0.0251 0.084
Brugia malayi RhoGEF domain containing protein 0.0031 0.0012 0.0011
Echinococcus granulosus heat shock protein 90 0.0077 0.0198 0.0197
Toxoplasma gondii PHD-finger domain-containing protein 0.0091 0.0253 0.1928
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0018 0.0019
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0161 0.0161
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0077 0.0075
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0061 0.0178
Schistosoma mansoni vesicular amine transporter 0.003 0.0007 0.0007
Plasmodium falciparum heat shock protein 90, putative 0.0343 0.1272 1
Echinococcus granulosus protein kinase c iota type 0.0504 0.1924 0.1923
Loa Loa (eye worm) hypothetical protein 0.0054 0.0103 0.0112
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0044 0.0065 0.0063
Loa Loa (eye worm) PHD-finger family protein 0.0091 0.0253 0.0277
Loa Loa (eye worm) AGC/PKN protein kinase 0.0044 0.0065 0.0069
Echinococcus granulosus NDR protein kinase 0.0044 0.0065 0.0063
Onchocerca volvulus 0.0047 0.0077 0.0255
Brugia malayi beta-lactamase family protein 0.0043 0.0061 0.0065
Entamoeba histolytica cysteine protease, putative 0.0051 0.0092 0.0648
Plasmodium falciparum thioredoxin reductase 0.0033 0.0018 0.0115
Echinococcus multilocularis muscleblind protein 1 0.0149 0.0486 0.0485
Entamoeba histolytica cysteine proteinase 2 0.0104 0.0305 0.2369
Loa Loa (eye worm) jmjC domain-containing protein 0.0128 0.0402 0.0441
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.003 0.0005 0.0012
Onchocerca volvulus 0.0446 0.169 0.6093
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.005
Trichomonas vaginalis bromodomain-containing protein, putative 0.0052 0.0095 0.0213
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0251 0.084
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0065
Trichomonas vaginalis heat shock protein, putative 0.0053 0.0098 0.0221
Echinococcus multilocularis insulin receptor 0.0731 0.2841 0.284
Brugia malayi Matrixin family protein 0.0035 0.0028 0.0029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0018 0.0017
Brugia malayi jmjC domain containing protein 0.0128 0.0402 0.0441
Echinococcus multilocularis tumor protein p63 0.0336 0.1245 0.1243
Loa Loa (eye worm) transcription factor SMAD2 0.0119 0.0365 0.04
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0112 0.0337 0.0335
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0016 0.0028
Echinococcus granulosus unc 13 munc13 0.0031 0.0012 0.001
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0029
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0033 0.0018 0.0113
Entamoeba histolytica hypothetical protein 0.0037 0.0035 0.0188
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0091 0.0205
Loa Loa (eye worm) hypothetical protein 0.0283 0.103 0.1132
Schistosoma mansoni cathepsin F (C01 family) 0.0112 0.0337 0.0337
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0044 0.0065 0.0063
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0026 0.0074
Loa Loa (eye worm) RasGEF domain-containing protein 0.0031 0.0012 0.0011
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0094 0.0267 0.2037
Leishmania major cathepsin L-like protease 0.0112 0.0337 0.3428
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0049 0.0084 0.0271
Loa Loa (eye worm) matrixin family protein 0.0086 0.0231 0.0253
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0033 0.0018 0.0115
Brugia malayi Protein kinase c protein 2 0.0032 0.0016 0.0016
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0144 0.0467 0.0465
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0061 0.0171
Schistosoma mansoni tyrosine kinase 0.0832 0.3253 0.3253
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0035
Echinococcus granulosus cysteine protease 0.0104 0.0305 0.0304
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0146 0.0144
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0029
Loa Loa (eye worm) hypothetical protein 0.0038 0.004 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0018 0.0017
Echinococcus granulosus cathepsin L 0.0051 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0129 0.0406 0.0405
Trypanosoma brucei Heat shock protein 83, putative 0.009 0.0251 0.2544
Echinococcus multilocularis Immunoglobulin 0.003 0.0007 0.0005
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0031 0.0012 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0051 0.0092 0.0207
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0144 0.0467 0.0465
Onchocerca volvulus 0.0112 0.0337 0.1197
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0018 0.005
Entamoeba histolytica hypothetical protein 0.0037 0.0035 0.0188
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0018 0.0113
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0005
Mycobacterium ulcerans beta-lactamase 0.0043 0.0061 0.0171
Echinococcus multilocularis transcription factor btf3 0.0035 0.0026 0.0024
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.01 0.029 0.029
Schistosoma mansoni serine/threonine protein kinase 0.0076 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Entamoeba histolytica hypothetical protein 0.0037 0.0035 0.0188
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.003 0.0005 0.0015
Plasmodium vivax heat shock protein 90, putative 0.006 0.0128 0.0981
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Loa Loa (eye worm) TAR-binding protein 0.0063 0.014 0.0152
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0191 0.0656 0.0655
Onchocerca volvulus Cathepsin L homolog 0.0112 0.0337 0.1197
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.005
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0016 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0037 0.0033 0.0061
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0084 0.0581
Brugia malayi cathepsin Z-like cysteine proteinase 0.0051 0.0092 0.01
Brugia malayi Muscleblind-like protein 0.0149 0.0486 0.0533
Brugia malayi beta-NAC-like protein 0.0035 0.0026 0.0026
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0053 0.0098 0.0106
Schistosoma mansoni hypothetical protein 0.0031 0.0012 0.0012
Plasmodium vivax vivapain-2 0.0112 0.0337 0.2627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Schistosoma mansoni hypothetical protein 0.0064 0.0146 0.0146
Trichomonas vaginalis glucosylceramidase, putative 0.1072 0.4223 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0028 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.027 0.0976 0.33
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0033 0.0018 0.015
Echinococcus granulosus heat shock protein 90 0.009 0.0251 0.0249
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0033 0.0018 0.005
Entamoeba histolytica heat shock protein 90, putative 0.009 0.0251 0.1931
Brugia malayi Cathepsin L-like precursor 0.0059 0.0124 0.0135
Entamoeba histolytica 90 kDa heat shock protein, putative 0.006 0.0128 0.0938
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0095 0.027 0.1012
Brugia malayi protein kinase C3,putative 0.0461 0.1749 0.1923
Mycobacterium ulcerans hypothetical protein 0.0049 0.0084 0.0264
Trypanosoma cruzi cruzipain precursor, putative 0.0157 0.0521 0.1756
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0029
Toxoplasma gondii heat shock protein 75, putative 0.006 0.0128 0.0962
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.0092 0.0697
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.0305 0.0305
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0092 0.0092
Echinococcus granulosus neuroglian 0.0038 0.0038 0.0036
Brugia malayi MH2 domain containing protein 0.0119 0.0365 0.04
Giardia lamblia Fructose-bisphosphate aldolase 0.014 0.0451 0.452
Toxoplasma gondii heat shock protein HSP90 0.009 0.0251 0.1913
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0092 0.0771
Echinococcus multilocularis cpg binding protein 0.0193 0.0666 0.0665
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.0161 0.0176
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0002
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0051 0.0092 0.0697
Onchocerca volvulus 0.005 0.0088 0.0296
Brugia malayi jmjC domain containing protein 0.0029 0.0004 0.0002
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0647 0.2504 1
Loa Loa (eye worm) zinc finger protein 0.0031 0.0012 0.0012
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0051 0.0092 0.0697
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Plasmodium vivax vivapain-1 0.0104 0.0305 0.2376
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0337 0.2625
Brugia malayi hypothetical protein 0.0032 0.0015 0.0015
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0051 0.0092 0.0697
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0376 0.1405 0.1405
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0031 0.0012 0.001
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0146 0.0144
Loa Loa (eye worm) hypothetical protein 0.005 0.0086 0.0093
Toxoplasma gondii histone lysine methyltransferase SET1 0.0349 0.1296 1
Schistosoma mansoni protein kinase C mu 0.0032 0.0016 0.0016
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0154 0.0506 0.0506
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0298 0.109 0.1089
Loa Loa (eye worm) jmjC domain-containing protein 0.0029 0.0004 0.0002
Schistosoma mansoni tyrosine kinase 0.0731 0.2841 0.2841
Loa Loa (eye worm) MH2 domain-containing protein 0.0119 0.0365 0.04
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0757 0.2949 0.2949
Echinococcus multilocularis lysine specific demethylase 5A 0.011 0.033 0.0329
Schistosoma mansoni transcription factor btf3 0.0035 0.0026 0.0026
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Schistosoma mansoni hypothetical protein 0.1368 0.542 0.542
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0146 0.0159
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Echinococcus multilocularis chromobox protein 1 0.0068 0.0161 0.016
Trichomonas vaginalis glucosylceramidase, putative 0.0703 0.2731 0.6464
Loa Loa (eye worm) beta-lactamase 0.0043 0.0061 0.0065
Brugia malayi PHD-finger family protein 0.0113 0.0343 0.0376
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0051 0.0111
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0061 0.0194
Echinococcus multilocularis lysine specific demethylase 6a 0.0029 0.0004 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Onchocerca volvulus Matrilysin homolog 0.0035 0.0028 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0191 0.0656 0.0655
Entamoeba histolytica cysteine proteinase, putative 0.0104 0.0305 0.2369
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0035 0.0035
Trichomonas vaginalis glucosylceramidase, putative 0.1072 0.4223 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.025 0.0249
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0084 0.0264
Echinococcus granulosus epidermal growth factor receptor 0.1224 0.4839 0.4838
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0217 0.0763 0.2997
Leishmania major cathepsin L-like protease 0.0112 0.0337 0.3428
Echinococcus granulosus roundabout 2 0.0048 0.0077 0.0076
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.014 0.0152
Loa Loa (eye worm) fibroinase 0.0112 0.0337 0.0369
Schistosoma mansoni heat shock protein 0.006 0.0128 0.0128
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0757 0.2949 0.2949
Mycobacterium ulcerans heat shock protein 90 0.0085 0.0228 0.0846
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Mycobacterium ulcerans acyl-CoA synthetase 0.0049 0.0084 0.0264
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Loa Loa (eye worm) bromodomain containing protein 0.0074 0.0185 0.0202
Echinococcus multilocularis heat shock protein 0.009 0.0251 0.0249
Schistosoma mansoni Neurotrimin precursor (hNT) 0.003 0.0007 0.0007
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Onchocerca volvulus 0.0049 0.0084 0.0281
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Entamoeba histolytica protein kinase, putative 0.0044 0.0065 0.0425
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Plasmodium vivax basic transcription factor 3b, putative 0.0035 0.0026 0.0172
Mycobacterium ulcerans hydrolase 0.0043 0.0059 0.0166
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0018 0.015
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Entamoeba histolytica cysteine protease, putative 0.0112 0.0337 0.2625
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0033 0.0018 0.015
Echinococcus granulosus endoplasmin 0.0085 0.0228 0.0227
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0051 0.0092 0.0207
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.1072 0.4223 0.4648
Echinococcus multilocularis roundabout 2 0.0048 0.0077 0.0076
Loa Loa (eye worm) heat shock protein 90 0.009 0.0251 0.0275
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0044 0.0065 0.0063
Brugia malayi Papain family cysteine protease containing protein 0.0051 0.0092 0.01
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0032 0.0016 0.0016
Loa Loa (eye worm) hypothetical protein 0.0337 0.125 0.1375
Echinococcus granulosus protein tyrosine kinase 0.0832 0.3253 0.3252
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0077 0.0075
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0043 0.0059 0.0166
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0647 0.2504 1
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0051 0.0092 0.01
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Trypanosoma cruzi heat shock protein 90, putative 0.0077 0.0198 0.066
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0051 0.0092 0.0697
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0085 0.0228 0.2313
Schistosoma mansoni nephrin 0.0038 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Plasmodium falciparum serine repeat antigen 7 0.0051 0.0092 0.0697
Echinococcus multilocularis cathepsin L 0.0051 0.0092 0.0091
Entamoeba histolytica protein kinase, putative 0.0044 0.0065 0.0425
Toxoplasma gondii cathepsin CPC1 0.0051 0.0092 0.0684
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0731 0.2841 0.284
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.1009 0.3986
Schistosoma mansoni hypothetical protein 0.0064 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0037 0.0035 0.0035
Echinococcus multilocularis cathepsin L 0.0104 0.0305 0.0304
Schistosoma mansoni tyrosine kinase 0.0036 0.0032 0.0032
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0146 0.0144
Schistosoma mansoni methyl-cpg binding protein mbd 0.0068 0.0161 0.0161
Entamoeba histolytica protein kinase, putative 0.0044 0.0065 0.0425
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0018 0.0151
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0146 0.0144
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0033 0.0018 0.0115
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0448 0.0492
Loa Loa (eye worm) hypothetical protein 0.004 0.0046 0.0049
Loa Loa (eye worm) hypothetical protein 0.0139 0.0448 0.0492
Trypanosoma cruzi heat shock protein 85, putative 0.009 0.0251 0.084
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Brugia malayi Pre-SET motif family protein 0.0627 0.242 0.2663
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0129 0.0406 0.0405
Plasmodium falciparum phd finger protein, putative 0.0091 0.0253 0.1965
Giardia lamblia Cathepsin B precursor 0.027 0.0976 1
Entamoeba histolytica cysteine proteinase 1, putative 0.0104 0.0305 0.2369
Loa Loa (eye worm) jmjC domain-containing protein 0.0188 0.0645 0.0708
Echinococcus multilocularis cathepsin b 0.0757 0.2949 0.2948
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0031 0.0012 0.0012
Schistosoma mansoni tyrosine kinase 0.1224 0.4839 0.4839
Echinococcus multilocularis raf serine:threonine protein kinase 0.005 0.0089 0.0087
Onchocerca volvulus Tyrosine kinase homolog 0.0473 0.1797 0.6484
Toxoplasma gondii NAC domain-containing protein 0.0035 0.0026 0.0169
Brugia malayi Protein kinase domain containing protein 0.0032 0.0016 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0253 0.1965
Plasmodium falciparum glutathione reductase 0.0033 0.0018 0.0115
Loa Loa (eye worm) hypothetical protein 0.0149 0.0486 0.0533
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0035
Schistosoma mansoni bromodomain containing protein 0.0031 0.0009 0.0009
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0035 0.0034
Schistosoma mansoni hypothetical protein 0.005 0.0088 0.0088
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0241 0.0861 0.3392
Brugia malayi PHD-finger family protein 0.0047 0.0077 0.0083
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.005
Loa Loa (eye worm) hypothetical protein 0.0044 0.0065 0.0069
Toxoplasma gondii Hsp90 domain-containing protein 0.0343 0.1272 0.9815
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.01
Trypanosoma cruzi ISWI complex protein 0.0061 0.0133 0.0438
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Onchocerca volvulus 0.0043 0.0061 0.0197
Echinococcus granulosus jumonji domain containing protein 0.0127 0.0397 0.0396
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0077 0.0077
Brugia malayi PHD-finger family protein 0.0091 0.0253 0.0277
Trypanosoma cruzi cruzipain precursor, putative 0.0053 0.0098 0.032
Entamoeba histolytica cysteine protease, putative 0.0051 0.0092 0.0648
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0051 0.0092 0.0207
Schistosoma mansoni protein kinase C 0.0031 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Onchocerca volvulus Alhambra homolog 0.0091 0.0253 0.0893
Plasmodium vivax vivapain-3 0.0104 0.0305 0.2376
Giardia lamblia Cysteine protease 0.0051 0.0092 0.0771
Brugia malayi diacylglycerol kinase 0.0031 0.0012 0.0011
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0044 0.0065 0.0069
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0094 0.0267 0.0266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0092 0.0207
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0091 0.0205
Brugia malayi CXXC zinc finger family protein 0.0176 0.0595 0.0654
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Onchocerca volvulus 0.0031 0.0012 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0112 0.0337 0.1131
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0061 0.0171
Schistosoma mansoni hypothetical protein 0.25 1 1
Onchocerca volvulus 0.0104 0.0307 0.1089
Plasmodium falciparum heat shock protein 90, putative 0.0053 0.0098 0.0741
Plasmodium vivax serine-repeat antigen (SERA) 0.0051 0.0092 0.0697
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0061 0.0133
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0051 0.0092 0.0771
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0061 0.0194
Brugia malayi Protein kinase domain containing protein 0.0842 0.3292 0.3622
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0012 0.0001
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0047 0.0075 0.0073
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0042 0.0244
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0042 0.0303
Brugia malayi Cathepsin L-like precursor 0.0112 0.0337 0.0369
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0161 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0031 0.0012 0.0011
Loa Loa (eye worm) hypothetical protein 0.003 0.0007 0.0006
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0051 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0053 0.0098 0.0106
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0051 0.0092 0.0771
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0161 0.0371
Echinococcus multilocularis serine:threonine protein kinase N2 0.0044 0.0065 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0092 0.0207
Brugia malayi isocitrate dehydrogenase 0.0033 0.0018 0.0019
Brugia malayi RhoGAP domain containing protein 0.0031 0.0012 0.0011
Echinococcus multilocularis 0.0702 0.2725 0.2724
Trichomonas vaginalis glucosylceramidase, putative 0.0741 0.2885 0.6827
Onchocerca volvulus 0.0296 0.1083 0.3899
Giardia lamblia Cathepsin L precursor 0.0051 0.0092 0.0771
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0627 0.242 0.2663
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0061 0.0171
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0047 0.0075 0.0073
Trypanosoma brucei heat shock protein 90, putative 0.009 0.0251 0.2544
Brugia malayi Cathepsin L-like precursor 0.0059 0.0124 0.0135
Brugia malayi AMP-binding enzyme family protein 0.0049 0.0084 0.0091
Echinococcus multilocularis thioredoxin glutathione reductase 0.0095 0.027 0.0268
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0112 0.0337 0.0369
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0062 0.0135 0.0471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0035
Echinococcus multilocularis cysteine protease 0.0112 0.0337 0.0335
Plasmodium vivax glutathione reductase, putative 0.0095 0.027 0.2099
Brugia malayi Papain family cysteine protease containing protein 0.0104 0.0305 0.0334
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0647 0.2504 1
Brugia malayi Matrixin family protein 0.0035 0.0028 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0112 0.0337 0.0788
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0051 0.0092 0.0697
Leishmania major cathepsin L-like protease 0.0112 0.0337 0.3428
Trypanosoma cruzi Heat shock protein 83, putative 0.009 0.0251 0.084
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0217 0.0763 0.3002
Schistosoma mansoni cpg binding protein 0.0193 0.0666 0.0666
Giardia lamblia Cathepsin L precursor 0.0051 0.0092 0.0771
Onchocerca volvulus Matrilysin homolog 0.0079 0.0203 0.0711
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.1224 0.4839 0.4838
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0757 0.2949 1
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.027 0.0976 0.0976
Entamoeba histolytica protein kinase, putative 0.0044 0.0065 0.0425
Entamoeba histolytica hypothetical protein 0.0035 0.0026 0.011
Brugia malayi jmjC domain containing protein 0.0298 0.109 0.1199
Leishmania major cathepsin L-like protease 0.0157 0.0521 0.532
Loa Loa (eye worm) hypothetical protein 0.0037 0.0033 0.0035
Brugia malayi Cathepsin L-like precursor 0.0112 0.0337 0.0369
Plasmodium falciparum thioredoxin reductase 0.0095 0.027 0.2099
Entamoeba histolytica cysteine proteinase, putative 0.0112 0.0337 0.2625
Echinococcus multilocularis basement membrane specific heparan sulfate 0.003 0.0007 0.0005
Brugia malayi Cathepsin L-like precursor 0.0112 0.0337 0.0369
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0051 0.0092 0.0092
Schistosoma mansoni hypothetical protein 0.1368 0.542 0.542
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0052 0.0095 0.0704
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0037 0.0033 0.0061
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0061 0.0059
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0104 0.0305 0.3102
Brugia malayi Hr1 repeat family protein 0.0044 0.0065 0.0069
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.0092 0.0092
Echinococcus granulosus histone acetyltransferase KAT2B 0.0052 0.0095 0.0093
Plasmodium falciparum cysteine proteinase falcipain 1 0.0104 0.0305 0.2376
Brugia malayi F/Y-rich N-terminus family protein 0.0094 0.0266 0.0292
Echinococcus multilocularis protein kinase c iota type 0.0504 0.1924 0.1923
Toxoplasma gondii cathepsin CPC2 0.0051 0.0092 0.0684
Loa Loa (eye worm) TK/FAK protein kinase 0.0842 0.3292 0.3622
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Leishmania major heat shock protein, putative 0.006 0.0128 0.128
Brugia malayi fibroinase precursor 0.0051 0.0092 0.01
Loa Loa (eye worm) heat shock protein 75 0.006 0.0128 0.0139
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Echinococcus multilocularis Rac GTPase activating protein 1 0.0031 0.0012 0.001
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0012 0.0011
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0051 0.0091 0.0205
Schistosoma mansoni chromobox protein 0.0068 0.0161 0.0161
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.2582 0.2582
Brugia malayi Fibronectin type III domain containing protein 0.003 0.0007 0.0006
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0061 0.0133
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0018 0.0017
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 0.1001
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0146 0.0159
Trypanosoma cruzi cysteine peptidase, putative 0.0104 0.0305 0.1024
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0044 0.0065 0.0069
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0033 0.0018 0.015
Echinococcus granulosus cathepsin l1 0.0112 0.0337 0.0335
Echinococcus granulosus muscleblind protein 0.0149 0.0486 0.0485
Plasmodium vivax SET domain protein, putative 0.0093 0.0262 0.2035
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0521 0.1756
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.004 0.0046 0.0045
Toxoplasma gondii diacylglycerol kinase, putative 0.0031 0.0012 0.0064
Echinococcus multilocularis peptidase Clp (S14 family) 0.0062 0.0135 0.0134
Trichomonas vaginalis helicase, putative 0.004 0.0046 0.0097
Brugia malayi Matrixin family protein 0.0086 0.0231 0.0253
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0112 0.0337 0.0788
Echinococcus granulosus cathepsin l cysteine peptidase 0.0112 0.0337 0.0335
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0065 0.0065
Loa Loa (eye worm) matrixin family protein 0.0079 0.0203 0.0222
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0061 0.0133
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0757 0.2949 0.2949
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0086 0.0651
Schistosoma mansoni hypothetical protein 0.0064 0.0146 0.0146
Leishmania major hypothetical protein, conserved 0.0061 0.0133 0.1326
Echinococcus multilocularis phd:f box containing protein 0.0029 0.0004 0.0002
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Plasmodium falciparum acyl-CoA synthetase 0.0037 0.0033 0.0235
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0077 0.0198 0.0197
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0252 0.0906 0.0905
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0105 0.0308 0.1033
Echinococcus multilocularis protein kinase c eta type 0.0031 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0029 0.0004 0.0002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0033 0.0018 0.005
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0104 0.0305 0.0305
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0029 0.0004 0.0004
Toxoplasma gondii cathepsin B 0.027 0.0976 0.752
Loa Loa (eye worm) hypothetical protein 0.0091 0.0253 0.0277
Brugia malayi Protein kinase domain containing protein 0.0044 0.0065 0.0069
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0033 0.0018 0.015
Echinococcus granulosus serine:threonine protein kinase N2 0.0044 0.0065 0.0063
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Brugia malayi Furin-like cysteine rich region family protein 0.2274 0.9084 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.025 0.0274
Loa Loa (eye worm) hypothetical protein 0.0051 0.0092 0.01
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0047 0.0075 0.0074
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0091
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0016 0.0016
Brugia malayi Cathepsin L-like precursor 0.0112 0.0337 0.0369
Plasmodium falciparum serine repeat antigen 9 0.0051 0.0092 0.0697
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0033 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0167 0.0559 0.0613
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Trypanosoma brucei rac serine-threonine kinase, putative 0.0044 0.0065 0.0626
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0043 0.0061 0.0133
Echinococcus granulosus heat shock protein 0.009 0.0251 0.0249
Brugia malayi cathepsin L precursor 0.0051 0.0092 0.01
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0033 0.0018 0.015
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.0092 0.0648
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0091 0.0205
Brugia malayi Cathepsin L-like precursor 0.0053 0.0098 0.0106
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0103 0.0102
Schistosoma mansoni unc-13 (munc13) 0.0035 0.0028 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.0157 0.0521 0.1756
Giardia lamblia Heat shock protein HSP 90-alpha 0.0077 0.0198 0.1878
Giardia lamblia Hypothetical protein 0.0051 0.0092 0.0771
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0076 0.0192 0.019
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0217 0.0763 0.2997
Toxoplasma gondii preprocathepsin c precursor, putative 0.0051 0.0092 0.0684
Brugia malayi Bromodomain containing protein 0.0314 0.1154 0.1269
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Echinococcus granulosus protein kinase c epsilon type 0.0076 0.0192 0.019
Schistosoma mansoni tar DNA-binding protein 0.0063 0.014 0.014
Brugia malayi Protein kinase domain containing protein 0.0731 0.2841 0.3127
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0091
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.014 0.0451 0.3547
Trypanosoma cruzi heat shock protein 85, putative 0.0077 0.0198 0.066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0084 0.0091
Entamoeba histolytica acyl-coA synthetase, putative 0.0049 0.0084 0.0581
Loa Loa (eye worm) PHD-finger family protein 0.0083 0.0219 0.0239
Plasmodium vivax heat shock protein 86, putative 0.009 0.0251 0.1949
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0061 0.0065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.025 0.0249
Leishmania major trypanothione reductase 0.0095 0.027 0.2739
Leishmania major 4-coumarate:coa ligase-like protein 0.0049 0.0084 0.0824
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0007 0.0006
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.006 0.0128 0.0127
Loa Loa (eye worm) hypothetical protein 0.0296 0.1083 0.1191
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 0.5764
Echinococcus multilocularis peregrin 0.0104 0.0306 0.0304
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0103 0.0102
Loa Loa (eye worm) hypothetical protein 0.0059 0.0124 0.0135
Entamoeba histolytica cysteine protease, putative 0.0104 0.0305 0.2369
Echinococcus granulosus Protein kinase C brain isozyme 0.0076 0.0192 0.019
Onchocerca volvulus Matrix metalloproteinase homolog 0.0079 0.0203 0.0711
Brugia malayi beta-lactamase 0.0043 0.0061 0.0065
Giardia lamblia Cathepsin L precursor 0.0051 0.0092 0.0771
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0154 0.0506 0.0505
Schistosoma mansoni cathepsin F (C01 family) 0.0112 0.0337 0.0337
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0044 0.0065 0.0069
Mycobacterium leprae PROBABLE HYDROLASE 0.0043 0.0059 0.0173
Echinococcus granulosus thioredoxin glutathione reductase 0.0095 0.027 0.0268
Giardia lamblia Cathepsin L precursor 0.0051 0.0092 0.0771
Entamoeba histolytica acyl-CoA synthetase, putative 0.0049 0.0084 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Schistosoma mansoni tar DNA-binding protein 0.0063 0.014 0.014
Schistosoma mansoni hypothetical protein 0.0083 0.0219 0.0219
Brugia malayi Hsp90 protein 0.006 0.0128 0.0139
Plasmodium vivax unspecified product 0.0053 0.0098 0.0743
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0035 0.0025 0.0029
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0051 0.0092 0.0697
Loa Loa (eye worm) MBCTL1 0.0054 0.0103 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.014 0.0451 0.1058
Schistosoma mansoni tyrosine kinase 0.1205 0.4762 0.4762
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0062 0.0135 0.0471
Loa Loa (eye worm) hypothetical protein 0.0043 0.0061 0.0065
Brugia malayi AF-10 protein 0.003 0.0005 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Loa Loa (eye worm) hypothetical protein 0.0047 0.0077 0.0083
Mycobacterium leprae Probable lipase LipE 0.0043 0.0061 0.0178
Schistosoma mansoni tar DNA-binding protein 0.0063 0.014 0.014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0052 0.0095 0.0718
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0051 0.0091 0.0205
Plasmodium vivax hypothetical protein, conserved 0.004 0.0048 0.0353
Trichomonas vaginalis chromobox protein, putative 0.0068 0.0161 0.0371
Trichomonas vaginalis heat shock protein, putative 0.0066 0.0151 0.0346
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0018 0.0019
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0051 0.0092 0.0648
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0094 0.0267 1
Echinococcus multilocularis heat shock protein 90 0.009 0.0251 0.0249
Echinococcus granulosus N chimaerin 0.0031 0.0012 0.001
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0018 0.0018
Trypanosoma cruzi transcription factor btf3, putative 0.0035 0.0026 0.0074
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Loa Loa (eye worm) cysteine protease 0.0112 0.0337 0.0369
Echinococcus granulosus cathepsin L cysteine protease 0.0104 0.0305 0.0304
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0046 0.0097
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0051 0.0092 0.0092
Mycobacterium tuberculosis Conserved protein 0.0043 0.0061 0.0171
Plasmodium falciparum basic transcription factor 3b, putative 0.0035 0.0026 0.0172
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0061 0.0061
Brugia malayi mbt repeat family protein 0.0047 0.0077 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0092 0.0207
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0032 0.0016 0.0016
Onchocerca volvulus 0.0051 0.0092 0.0311
Loa Loa (eye worm) hypothetical protein 0.0184 0.063 0.0692
Schistosoma mansoni cpg binding protein 0.0193 0.0666 0.0666
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0233 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0051 0.0092 0.0207
Trichomonas vaginalis AGC family protein kinase 0.0044 0.0065 0.0142
Treponema pallidum heat shock protein 90 0.0085 0.0228 0.4878
Brugia malayi protein kinase C II. 0.0076 0.0192 0.0209
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0093 0.0262 0.1997
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0037 0.0033 0.0612
Schistosoma mansoni heat shock protein 0.009 0.0251 0.0251
Schistosoma mansoni hypothetical protein 0.0139 0.0448 0.0448
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0112 0.0337 0.0369
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0157 0.0521 0.532
Leishmania major cathepsin L-like protease 0.0157 0.0521 0.532
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0061 0.0171
Echinococcus granulosus tar DNA binding protein 0.0063 0.014 0.0138
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0035 0.0028 0.0028
Leishmania major heat shock protein 83-1 0.009 0.0251 0.2544
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.004 0.0083
Echinococcus granulosus fetal alzheimer antigen falz 0.01 0.029 0.0289
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0094 0.0267 0.2075
Echinococcus multilocularis serine:threonine protein kinase 38 0.0044 0.0065 0.0063
Schistosoma mansoni serine/threonine protein kinase 0.0044 0.0065 0.0065
Brugia malayi mbt repeat family protein 0.0047 0.0077 0.0083
Trypanosoma cruzi trypanothione reductase, putative 0.0095 0.027 0.0904
Schistosoma mansoni serine/threonine kinase 0.0044 0.0065 0.0065
Echinococcus multilocularis N chimaerin 0.0031 0.0012 0.001
Trypanosoma brucei heat shock protein, putative 0.009 0.0251 0.2544
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0337 0.125 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0112 0.0337 0.0788
Mycobacterium tuberculosis Probable dehydrogenase 0.0217 0.0763 0.2997
Loa Loa (eye worm) hypothetical protein 0.0059 0.0124 0.0135
Echinococcus multilocularis cathepsin b 0.0757 0.2949 0.2948
Schistosoma mansoni bromodomain containing protein 0.0267 0.0964 0.0964

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 5.0119 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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