Detailed information for compound 1429270

Basic information

Technical information
  • TDR Targets ID: 1429270
  • Name: N-(2,5-dimethoxyphenyl)-2-(3-ethyl-5-methyl-7 -oxo-2-sulfanylidene-[1,3]thiazolo[4,5-d]pyri midin-6-yl)acetamide
  • MW: 420.506 | Formula: C18H20N4O4S2
  • H donors: 1 H acceptors: 2 LogP: 1.63 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1NC(=O)Cn1c(C)nc2c(c1=O)sc(=S)n2CC)OC
  • InChi: 1S/C18H20N4O4S2/c1-5-21-16-15(28-18(21)27)17(24)22(10(2)19-16)9-14(23)20-12-8-11(25-3)6-7-13(12)26-4/h6-8H,5,9H2,1-4H3,(H,20,23)
  • InChiKey: HNEIJXNNCQKRQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2,5-dimethoxyphenyl)-2-(3-ethyl-5-methyl-7-oxo-2-thioxo-thiazolo[4,5-d]pyrimidin-6-yl)acetamide
  • N-(2,5-dimethoxyphenyl)-2-(3-ethyl-5-methyl-7-oxo-2-thioxo-6-thiazolo[4,5-d]pyrimidinyl)acetamide
  • N-(2,5-dimethoxyphenyl)-2-(3-ethyl-7-keto-5-methyl-2-thioxo-thiazolo[4,5-d]pyrimidin-6-yl)acetamide
  • N-(2,5-dimethoxyphenyl)-2-(3-ethyl-5-methyl-7-oxo-2-sulfanylidene-[1,3]thiazolo[4,5-d]pyrimidin-6-yl)ethanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0015 0.001 0.001
Schistosoma mansoni smad1 5 8 and 0.0025 0.0064 0.0091
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Echinococcus multilocularis Smad4 0.0025 0.0064 0.0064
Echinococcus multilocularis inositol monophosphatase 1 0.0023 0.0053 0.0053
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0134
Brugia malayi hypothetical protein 0.0057 0.0226 0.1018
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.0372 0.1686
Schistosoma mansoni RAR-like nuclear receptor 0.0024 0.0059 0.0084
Plasmodium vivax SET domain protein, putative 0.0056 0.0222 0.4162
Brugia malayi MH1 domain containing protein 0.0025 0.0064 0.029
Echinococcus granulosus inositol monophosphatase 1 0.0023 0.0053 0.0215
Onchocerca volvulus 0.0042 0.0152 0.0652
Echinococcus multilocularis lysosomal alpha glucosidase 0.0258 0.1261 0.1261
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0372 0.7009
Schistosoma mansoni lamin 0.0042 0.0152 0.0214
Echinococcus granulosus beta LACTamase domain containing family member 0.0085 0.0372 0.1501
Mycobacterium ulcerans hypothetical protein 0.0085 0.0372 0.0486
Loa Loa (eye worm) intermediate filament protein 0.0042 0.0152 0.0214
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0056 0.0222 0.0222
Loa Loa (eye worm) hypothetical protein 0.0057 0.0226 0.0319
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0116 0.053 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0049
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0018 0.0028 0.0497
Brugia malayi Glycosyl hydrolases family 31 protein 0.0021 0.0043 0.0194
Schistosoma mansoni hypothetical protein 0.0226 0.1098 0.1549
Loa Loa (eye worm) hypothetical protein 0.0098 0.0437 0.0616
Brugia malayi PHD-finger family protein 0.0063 0.0258 0.1161
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.001 0.0033
Echinococcus multilocularis histone acetyltransferase MYST2 0.0042 0.0151 0.0151
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0015 0.001 0.0033
Mycobacterium ulcerans aldehyde dehydrogenase 0.0092 0.0408 0.0538
Onchocerca volvulus 0.0024 0.0059 0.0229
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0149 0.2789
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0059 0.0084
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0031 0.0095 0.0103
Schistosoma mansoni ferritin 0.0019 0.0034 0.0048
Loa Loa (eye worm) PHD-finger family protein 0.0051 0.0193 0.0273
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0401 0.0566
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0344 0.1706 0.2408
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0024 0.0059 0.0084
Onchocerca volvulus Putative fad oxidoreductase 0.0116 0.053 0.238
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0116 0.053 0.2386
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0024 0.0059 0.0084
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0116 0.053 0.053
Schistosoma mansoni hypothetical protein 0.0025 0.0065 0.0091
Brugia malayi MH1 domain containing protein 0.0014 0.0006 0.0026
Schistosoma mansoni ran 0.0013 0.0002 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0024 0.0059 0.0268
Brugia malayi RNA, U transporter 1 0.0052 0.02 0.09
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0027 0.0469
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0094 0.0417 0.0589
Echinococcus multilocularis FTZ F1 alpha 0.0024 0.0059 0.0059
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0116 0.053 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0015 0.001 0.0038
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0024 0.0059 0.024
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0149 0.0171
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0018 0.0028 0.0497
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.001 0.0013
Toxoplasma gondii LsmAD domain-containing protein 0.0057 0.0226 0.424
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0015 0.001 0.0013
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0024 0.0059 0.0084
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0021 0.0043 0.0774
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0042 0.0148 0.0148
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0116 0.053 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0147 0.0688 0.0688
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0116 0.053 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0039 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0085 0.0372 0.0525
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0042 0.0151 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0085 0.0372 0.7009
Schistosoma mansoni hypothetical protein 0.004 0.0141 0.0198
Echinococcus multilocularis geminin 0.045 0.2249 0.2249
Plasmodium vivax ataxin-2 like protein, putative 0.0057 0.0226 0.424
Mycobacterium tuberculosis Probable hydrolase 0.0085 0.0372 0.0531
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0149 0.2789
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0024 0.0059 0.0084
Loa Loa (eye worm) latrophilin receptor protein 2 0.014 0.0657 0.0927
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0134
Trichomonas vaginalis sucrase-isomaltase, putative 0.0057 0.0228 0.103
Schistosoma mansoni smad1 5 8 and 0.0025 0.0064 0.0091
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.014 0.0657 0.0657
Loa Loa (eye worm) CYP4Cod1 0.0026 0.0065 0.0091
Echinococcus granulosus neutral alpha glucosidase AB 0.0057 0.0228 0.0921
Schistosoma mansoni sex comb on midleg homolog 0.0037 0.0125 0.0176
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0042 0.0149 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0086 0.0089
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.001 0.0013
Echinococcus multilocularis lamin 0.0042 0.0152 0.0152
Onchocerca volvulus 0.0149 0.0701 0.3167
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0019 0.0034 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0494 0.2477 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0228 0.103
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0116 0.053 0.2386
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.014 0.0657 0.0657
Brugia malayi hypothetical protein 0.0015 0.001 0.0043
Onchocerca volvulus Bile acid receptor homolog 0.0024 0.0059 0.0229
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0149 0.0673
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0116 0.053 0.071
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0116 0.053 0.071
Echinococcus granulosus lamin dm0 0.0042 0.0152 0.0613
Entamoeba histolytica hypothetical protein 0.0015 0.0009 0.0133
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0025 0.0064 0.0091
Toxoplasma gondii cytochrome p450 superfamily protein 0.0018 0.0028 0.0497
Schistosoma mansoni hypothetical protein 0.0494 0.2477 0.3496
Brugia malayi CXXC zinc finger family protein 0.0035 0.0112 0.0505
Schistosoma mansoni myelin transcription factor 1 myt1 0.0042 0.0151 0.0214
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0116 0.053 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0043 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0228 0.103
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0437 0.0616
Schistosoma mansoni fad oxidoreductase 0.0116 0.053 0.0747
Echinococcus multilocularis thyroid hormone receptor alpha 0.0024 0.0059 0.0059
Mycobacterium tuberculosis Probable esterase LipL 0.0085 0.0372 0.0531
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0116 0.053 0.2138
Schistosoma mansoni ferritin 0.0019 0.0034 0.0048
Loa Loa (eye worm) hypothetical protein 0.0085 0.0372 0.0525
Loa Loa (eye worm) hypothetical protein 0.1389 0.7086 1
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0042 0.0152 0.0214
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0134
Loa Loa (eye worm) hypothetical protein 0.0042 0.0152 0.0214
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0092 0.0408 0.0408
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0019 0.0034 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0088 0.0386 0.0386
Echinococcus granulosus lamin 0.0042 0.0152 0.0613
Schistosoma mansoni bromodomain containing protein 0.0157 0.0741 0.1046
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0149 0.2789
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0228 0.103
Schistosoma mansoni hypothetical protein 0.0303 0.1496 0.2111
Mycobacterium tuberculosis Probable lipase LipD 0.0085 0.0372 0.0531
Schistosoma mansoni cellular tumor antigen P53 0.004 0.014 0.0198
Loa Loa (eye worm) G protein alpha subunit 3 0.0015 0.001 0.0013
Echinococcus multilocularis neuropeptide s receptor 0.0399 0.199 0.199
Echinococcus granulosus tar DNA binding protein 0.0091 0.0401 0.1619
Schistosoma mansoni hypothetical protein 0.0018 0.0028 0.004
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0015 0.001 0.0043
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.0372 0.1686
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0021 0.0043 0.0774
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0043 0.0186
Toxoplasma gondii hypothetical protein 0.0116 0.053 1
Schistosoma mansoni retinoic acid receptor RXR 0.0024 0.0059 0.0084
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0401 0.0566
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0015 0.001 0.0043
Mycobacterium tuberculosis Conserved protein 0.0085 0.0372 0.0531
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0544 0.2735 0.4188
Schistosoma mansoni hypothetical protein 0.0037 0.0126 0.0178
Schistosoma mansoni smad1 5 8 and 0.0025 0.0064 0.0091
Plasmodium falciparum importin beta, putative 0.0018 0.0027 0.0469
Trypanosoma brucei cytochrome P450, putative 0.0026 0.0065 0.1184
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0088 0.0386 0.1559
Schistosoma mansoni apoferritin-2 0.0019 0.0034 0.0048
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0015 0.001 0.0013
Echinococcus granulosus tumor protein p63 0.0274 0.1346 0.5433
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0116 0.053 1
Brugia malayi hypothetical protein 0.0037 0.0122 0.0551
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0116 0.053 0.0747
Onchocerca volvulus 0.0085 0.0372 0.1658
Trypanosoma brucei importin beta-1 subunit, putative 0.0018 0.0027 0.0469
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0057 0.0228 0.0321
Plasmodium falciparum acyl-CoA synthetase 0.0031 0.0095 0.1753
Schistosoma mansoni ferritin 0.0019 0.0034 0.0048
Trypanosoma brucei ISWI complex protein 0.0037 0.0126 0.235
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0024 0.0059 0.0268
Plasmodium vivax importin-beta 2, putative 0.0018 0.0027 0.0469
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0116 0.053 1
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0116 0.053 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0085 0.0372 0.0531
Brugia malayi Pre-SET motif family protein 0.0386 0.192 0.8655
Schistosoma mansoni hypothetical protein 0.045 0.2249 0.3174
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0344 0.1706 0.2408
Echinococcus multilocularis mothers against decapentaplegic 5 0.0025 0.0064 0.0064
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0147 0.0688 0.2778
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.001 0.0013
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.0968
Brugia malayi hypothetical protein 0.0197 0.0949 0.4279
Toxoplasma gondii ABC1 family protein 0.0085 0.0372 0.7009
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0042 0.0151 0.0611
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.014 0.0657 0.2959
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0116 0.053 1
Schistosoma mansoni zinc finger protein 0.0037 0.0126 0.0178
Brugia malayi Intermediate filament tail domain containing protein 0.0042 0.0152 0.0685
Trypanosoma brucei glucosidase, putative 0.0057 0.0228 0.4281
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0116 0.053 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0092 0.0408 0.0538
Echinococcus multilocularis SAM and MBT domain containing protein 0.0037 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0134
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0226 0.424
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0116 0.053 1
Echinococcus granulosus guanine nucleotide binding protein subunit 0.0015 0.001 0.0038
Brugia malayi Cytochrome P450 family protein 0.0018 0.0028 0.0128
Echinococcus multilocularis tumor protein p63 0.0274 0.1346 0.1346
Loa Loa (eye worm) inositol-1 0.0023 0.0053 0.0075
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0116 0.053 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Schistosoma mansoni methyl-cpg binding protein mbd 0.0042 0.0148 0.0209
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0015 0.001 0.0013
Mycobacterium ulcerans lipase LipD 0.0085 0.0372 0.0486
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0042 0.0149 0.0187
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0042 0.0149 0.0171
Loa Loa (eye worm) nuclear factor I 0.0014 0.0006 0.0008
Plasmodium vivax hypothetical protein, conserved 0.0085 0.0372 0.7009
Brugia malayi RE18450p 0.0116 0.053 0.2386
Echinococcus granulosus neuropeptide s receptor 0.0399 0.199 0.8033
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.001 0.0043
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0059 0.024
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0092 0.0408 0.0587
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0009 0.0032
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.001 0.0013
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0009 0.0032
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.0015 0.001 0.0013
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0116 0.053 0.0775
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0116 0.053 1
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0021 0.0043 0.0154
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.004 0.0141 0.0634
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0024 0.0059 0.0084
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.0968
Onchocerca volvulus 0.0042 0.0149 0.064
Trichomonas vaginalis ferritin, putative 0.0019 0.0034 0.0144
Schistosoma mansoni aldehyde dehydrogenase 0.0092 0.0408 0.0576
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0344 0.1706 0.2408
Brugia malayi Bromodomain containing protein 0.0186 0.0889 0.4006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0059 0.0059
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0123 0.0569 0.2559
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0116 0.053 0.053
Schistosoma mansoni fad oxidoreductase 0.0116 0.053 0.0747
Loa Loa (eye worm) hypothetical protein 0.002 0.0035 0.0049
Echinococcus granulosus cytoplasmic intermediate filament protein 0.002 0.0039 0.0157
Trypanosoma brucei PAB1-binding protein , putative 0.0057 0.0226 0.424
Echinococcus multilocularis lysosomal alpha glucosidase 0.0258 0.1261 0.1261
Schistosoma mansoni hypothetical protein 0.014 0.0657 0.0927
Schistosoma mansoni transcription factor LCR-F1 0.0068 0.0281 0.0397
Loa Loa (eye worm) MH1 domain-containing protein 0.0025 0.0064 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0085 0.0372 0.0525
Mycobacterium ulcerans hypothetical protein 0.0042 0.0149 0.0171
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0037 0.0125 0.0176
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0148 0.0696 0.0696
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0086 0.0089
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0021 0.0043 0.0774
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.0015 0.001 0.0013
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0065 0.1184
Brugia malayi beta-lactamase family protein 0.0085 0.0372 0.1676
Loa Loa (eye worm) hypothetical protein 0.0042 0.0148 0.0209
Onchocerca volvulus 0.004 0.0141 0.06
Echinococcus granulosus histone acetyltransferase MYST2 0.0042 0.0151 0.0611
Schistosoma mansoni inositol monophosphatase 0.0023 0.0053 0.0075
Loa Loa (eye worm) hypothetical protein 0.0302 0.1486 0.2098
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0116 0.053 0.238
Mycobacterium ulcerans aldehyde dehydrogenase 0.0092 0.0408 0.0538
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0086 0.0089
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0024 0.0059 0.024
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0024 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0106 0.0481 0.0679
Echinococcus multilocularis ferritin 0.0019 0.0034 0.0034
Echinococcus granulosus survival motor neuron protein 1 0.0197 0.0949 0.3833
Entamoeba histolytica G protein alpha subunit, putative 0.0015 0.001 0.0137
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Leishmania major importin beta-1 subunit, putative 0.0015 0.0009 0.0133
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0015 0.001 0.0043
Trichomonas vaginalis maltase-glucoamylase, putative 0.0021 0.0043 0.0186
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0022 0.0101
Loa Loa (eye worm) cytochrome P450 0.0018 0.0028 0.004
Mycobacterium ulcerans beta-lactamase 0.0085 0.0372 0.0486
Schistosoma mansoni hypothetical protein 0.045 0.2249 0.3174
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0344 0.1706 0.6888
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0401 0.0566
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0057 0.0228 0.4281
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0401 0.0566
Brugia malayi steroid hormone receptor 0.0024 0.0059 0.0268
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0028 0.0497
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0116 0.053 1
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0116 0.053 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0091 0.0401 0.0566
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0021 0.0041 0.0017
Echinococcus granulosus snurportin 1 0.0194 0.0933 0.3768
Echinococcus granulosus neuropeptide receptor A26 0.0399 0.199 0.8033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0149 0.0171
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0211
Brugia malayi G-protein alpha subunit 0.0015 0.001 0.0043
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0023 0.0053 0.0035
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0112 0.0158
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.002 0.0039 0.0039
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0053 0.0233
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.001 0.0013
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0013 0.0002 0.001
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0024 0.0059 0.0084
Trichomonas vaginalis penicillin-binding protein, putative 0.0085 0.0372 0.1686
Loa Loa (eye worm) hypothetical protein 0.0042 0.0151 0.0214
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0057 0.0228 0.0322
Echinococcus multilocularis cpg binding protein 0.0041 0.0146 0.0146
Loa Loa (eye worm) MBCTL1 0.0042 0.0151 0.0214
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0024 0.0059 0.0059
Echinococcus granulosus importin subunit beta 1 0.0018 0.0027 0.0109
Brugia malayi Smad1 0.0025 0.0064 0.029
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0116 0.053 1
Entamoeba histolytica hypothetical protein 0.0068 0.0281 0.5292
Loa Loa (eye worm) hypothetical protein 0.01 0.0447 0.0631
Echinococcus granulosus cpg binding protein 0.0041 0.0146 0.059
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0194 0.0933 0.1317
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0098 0.0437 0.0437
Brugia malayi Cytochrome P450 family protein 0.0026 0.0065 0.0292
Schistosoma mansoni hypothetical protein 0.0194 0.0933 0.1317
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0068 0.0281 0.1136
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0015 0.001 0.0038
Echinococcus granulosus FTZ F1 alpha 0.0024 0.0059 0.024
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0085 0.0372 0.0531
Loa Loa (eye worm) TAR-binding protein 0.0091 0.0401 0.0566
Trichomonas vaginalis esterase, putative 0.0085 0.0372 0.1686
Onchocerca volvulus 0.0085 0.0372 0.1658
Leishmania major hypothetical protein, conserved 0.0037 0.0126 0.235
Brugia malayi Steroid receptor seven-up type 2 0.0024 0.0059 0.0268
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0059 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0085 0.0372 0.1686
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0228 0.4281
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0015 0.001 0.0013
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0024 0.0059 0.0268
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.001 0.0043
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0015 0.001 0.0013
Loa Loa (eye worm) bromodomain containing protein 0.0043 0.0156 0.022
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0344 0.1706 0.7689
Entamoeba histolytica hypothetical protein 0.0068 0.0281 0.5292
Trichomonas vaginalis inositol monophosphatase, putative 0.0023 0.0053 0.0233
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0015 0.001 0.0043
Schistosoma mansoni d-amino acid oxidase 0.1389 0.7086 1
Echinococcus granulosus guanine nucleotide binding protein G protein 0.0015 0.001 0.0038
Echinococcus granulosus GPCR family 2 0.014 0.0657 0.2651
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.014 0.0657 0.2651
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0116 0.053 0.2138
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0024 0.0059 0.0268
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0024 0.0059 0.0268
Loa Loa (eye worm) mbt repeat family protein 0.0037 0.0125 0.0176
Schistosoma mansoni hypothetical protein 0.0068 0.0281 0.0397
Loa Loa (eye worm) hypothetical protein 0.0085 0.0372 0.0525
Mycobacterium leprae conserved hypothetical protein 0.0085 0.0372 0.0486
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0116 0.053 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0024 0.0059 0.0059
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0444 0.2219 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0059 0.0268
Schistosoma mansoni apoferritin-2 0.0019 0.0034 0.0048
Schistosoma mansoni cpg binding protein 0.0041 0.0146 0.0206
Plasmodium vivax acyl-CoA synthetase, putative 0.0031 0.0095 0.1753
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0015 0.001 0.0013
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Onchocerca volvulus 0.0439 0.2194 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0085 0.0372 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0059 0.0268
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.014 0.0657 0.2651
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0228 0.103
Leishmania major cytochrome p450-like protein 0.0018 0.0028 0.0497
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0042 0.0149 0.0171
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0148 0.0696 0.281
Leishmania major hypothetical protein, conserved 0.0085 0.0372 0.7009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.003 0.0086 0.0089
Echinococcus granulosus lysosomal alpha glucosidase 0.0258 0.1261 0.5092
Echinococcus granulosus expressed protein 0.0015 0.001 0.0038
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0026 0.0065 0.0051
Leishmania major cytochrome p450-like protein 0.0026 0.0065 0.1184
Echinococcus granulosus Smad4 0.0025 0.0064 0.026
Schistosoma mansoni coup transcription factor 0.0024 0.0059 0.0084
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.0015 0.001 0.0013
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0025 0.0064 0.0064
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0092 0.0408 0.7693
Loa Loa (eye worm) hypothetical protein 0.0085 0.0372 0.0525
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0344 0.1706 0.1706
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0015 0.001 0.0033
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0149 0.0673
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0013
Brugia malayi RNA binding protein 0.0091 0.0401 0.1807
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0043 0.0186
Mycobacterium ulcerans esterase/lipase LipP 0.0085 0.0372 0.0486
Schistosoma mansoni alpha-glucosidase 0.0222 0.1076 0.1519
Schistosoma mansoni alpha glucosidase 0.0057 0.0228 0.0322
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0211
Echinococcus multilocularis GPCR, family 2 0.014 0.0657 0.0657
Loa Loa (eye worm) transcription factor SMAD2 0.0373 0.1856 0.2619
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0057 0.0228 0.0228
Brugia malayi beta-lactamase family protein 0.0085 0.0372 0.1676
Echinococcus granulosus cytochrome P450 2K1 0.0018 0.0028 0.0115
Mycobacterium ulcerans bacterioferritin BfrB 0.0019 0.0034 0.0007
Echinococcus granulosus fetal alzheimer antigen falz 0.0057 0.0228 0.0919
Onchocerca volvulus 0.0042 0.0152 0.0652
Brugia malayi RNA recognition motif domain containing protein 0.0091 0.0401 0.1807
Mycobacterium leprae Probable lipase LipE 0.0085 0.0372 0.0486
Loa Loa (eye worm) hypothetical protein 0.004 0.014 0.0198
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0024 0.0059 0.024
Schistosoma mansoni thyroid hormone receptor 0.0024 0.0059 0.0084
Echinococcus granulosus intermediate filament protein 0.0042 0.0152 0.0613
Loa Loa (eye worm) hypothetical protein 0.0173 0.0825 0.1164
Echinococcus granulosus expressed protein 0.0019 0.0034 0.0136
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0043 0.0186
Brugia malayi mbt repeat family protein 0.0037 0.0125 0.0563
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0098 0.0437 0.0616
Mycobacterium ulcerans bacterioferritin BfrA 0.0019 0.0034 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0057 0.0228 0.4281
Loa Loa (eye worm) cytochrome P450 family protein 0.007 0.0292 0.0411
Brugia malayi photoreceptor-specific nuclear receptor 0.0024 0.0059 0.0268
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0015 0.001 0.0043
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0024 0.0059 0.0084
Brugia malayi Cytochrome P450 family protein 0.007 0.0292 0.1314
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0344 0.1706 0.6888
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0344 0.1706 0.1706
Brugia malayi nuclear hormone receptor 0.0024 0.0059 0.0268
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0116 0.053 0.238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0024 0.0059 0.0084
Echinococcus multilocularis neutral alpha glucosidase AB 0.0057 0.0228 0.0228
Echinococcus granulosus TGF beta signal transducer SmadC 0.0025 0.0064 0.026
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0024 0.0059 0.0268
Brugia malayi AMP-binding enzyme family protein 0.0042 0.0149 0.0673
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0023 0.005 0.0071
Trypanosoma cruzi cytochrome P450, putative 0.0026 0.0065 0.1184
Brugia malayi Calcitonin receptor-like protein seb-1 0.0444 0.2219 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0024 0.0059 0.024
Schistosoma mansoni hypothetical protein 0.014 0.0657 0.0927
Echinococcus granulosus SAM and MBT domain containing protein 0.0037 0.0125 0.0504
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0149 0.0171
Entamoeba histolytica hypothetical protein 0.0068 0.0281 0.5292
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.0968
Toxoplasma gondii aldehyde dehydrogenase 0.0092 0.0408 0.7693
Onchocerca volvulus 0.0037 0.0125 0.0528
Loa Loa (eye worm) hypothetical protein 0.0123 0.0569 0.0802
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0024 0.0059 0.0059
Entamoeba histolytica acyl-coA synthetase, putative 0.0042 0.0149 0.2789
Echinococcus multilocularis survival motor neuron protein 1 0.0197 0.0949 0.0949
Echinococcus multilocularis musashi 0.0042 0.0152 0.0152
Chlamydia trachomatis D-amino acid dehydrogenase 0.0116 0.053 1
Schistosoma mansoni ran 0.0013 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0085 0.0372 0.0525
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0057 0.0228 0.4281
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.001 0.0033
Loa Loa (eye worm) hypothetical protein 0.0444 0.2219 0.3132
Brugia malayi Glycosyl hydrolases family 31 protein 0.0258 0.1261 0.5684
Mycobacterium tuberculosis Conserved protein 0.0085 0.0372 0.0531
Loa Loa (eye worm) hypothetical protein 0.0116 0.053 0.0747
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0059 0.0268
Loa Loa (eye worm) hypothetical protein 0.0042 0.0149 0.0211
Schistosoma mansoni tar DNA-binding protein 0.0091 0.0401 0.0566
Schistosoma mansoni alpha-glucosidase 0.0222 0.1076 0.1519
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0116 0.053 0.071
Onchocerca volvulus 0.004 0.014 0.0598
Leishmania major cytochrome p450-like protein 0.0018 0.0028 0.0497
Mycobacterium tuberculosis Conserved protein 0.0085 0.0372 0.0531
Brugia malayi MH1 domain containing protein 0.0025 0.0064 0.029
Schistosoma mansoni hypothetical protein 0.0051 0.0193 0.0273
Brugia malayi intermediate filament protein 0.0042 0.0152 0.0685
Echinococcus multilocularis snurportin 1 0.0194 0.0933 0.0933
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0042 0.0149 0.0171
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0226 0.424
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0042 0.0151 0.0682
Echinococcus multilocularis neuropeptide receptor A26 0.0399 0.199 0.199
Brugia malayi Latrophilin receptor protein 2 0.014 0.0657 0.2959
Trypanosoma cruzi PAB1-binding protein , putative 0.0057 0.0226 0.424
Echinococcus multilocularis beta LACTamase domain containing family member 0.0085 0.0372 0.0372
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0076 0.0323 0.0455
Brugia malayi N-terminal motif family protein 0.0123 0.0569 0.2562
Schistosoma mansoni sex comb on midleg homolog 0.0037 0.0125 0.0176
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0053 0.0207 0.0837
Leishmania major alpha glucosidase II subunit, putative 0.0057 0.0228 0.4281
Brugia malayi MH2 domain containing protein 0.0373 0.1856 0.8364
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.001 0.0033
Schistosoma mansoni NAD dehydrogenase 0.0116 0.053 0.0747
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0057 0.0228 0.4281
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0065 0.0261
Echinococcus multilocularis expressed protein 0.0019 0.0034 0.0034
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0056 0.0222 0.0313
Loa Loa (eye worm) steroid hormone receptor 0.0024 0.0059 0.0084
Brugia malayi mbt repeat family protein 0.0037 0.0125 0.0563
Schistosoma mansoni hypothetical protein 0.014 0.0657 0.0927
Onchocerca volvulus 0.0056 0.0222 0.0971
Loa Loa (eye worm) hypothetical protein 0.0116 0.053 0.0747
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0024 0.0059 0.0084
Trichomonas vaginalis alpha-glucosidase, putative 0.0021 0.0043 0.0186
Schistosoma mansoni lamin 0.0042 0.0152 0.0214
Brugia malayi hypothetical protein 0.0068 0.0281 0.1268
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0065 0.0091
Brugia malayi MH2 domain containing protein 0.0025 0.0064 0.029
Loa Loa (eye worm) MH2 domain-containing protein 0.0025 0.0064 0.0091
Echinococcus multilocularis importin subunit beta 1 0.0018 0.0027 0.0027
Trichomonas vaginalis penicillin-binding protein, putative 0.0085 0.0372 0.1686
Loa Loa (eye worm) hypothetical protein 0.0014 0.0006 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0386 0.192 0.271
Echinococcus multilocularis 0.0018 0.0028 0.0028
Brugia malayi MH1 domain containing protein 0.0014 0.0006 0.0026
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0019 0.0034 0.0008
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0092 0.0408 0.1647
Loa Loa (eye worm) hypothetical protein 0.0037 0.0125 0.0176
Brugia malayi ecdysteroid receptor 0.0024 0.0059 0.0268
Onchocerca volvulus 0.0035 0.0112 0.0469
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0042 0.0149 0.0187
Brugia malayi Bromodomain containing protein 0.0094 0.0416 0.1875
Brugia malayi nuclear receptor NHR-88 0.0024 0.0059 0.0268
Echinococcus granulosus ferritin 0.0019 0.0034 0.0136
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0015 0.001 0.0043
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0018 0.0028 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0024 0.0059 0.0268
Brugia malayi Cytochrome P450 family protein 0.0026 0.0065 0.0292
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0444 0.2219 0.3132
Schistosoma mansoni hypothetical protein 0.014 0.0657 0.0927
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0116 0.053 0.071
Schistosoma mansoni methyl-cpg binding protein mbd 0.0042 0.0148 0.0209
Loa Loa (eye worm) hypothetical protein 0.0085 0.0372 0.0525
Loa Loa (eye worm) hypothetical protein 0.0303 0.1496 0.2111
Echinococcus multilocularis smad 0.0025 0.0064 0.0064
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0009 0.0133
Echinococcus multilocularis tar DNA binding protein 0.0091 0.0401 0.0401
Loa Loa (eye worm) hypothetical protein 0.0018 0.0027 0.0038
Treponema pallidum bacterioferrin (TpF1) 0.0019 0.0034 0.5
Echinococcus multilocularis polycomb protein SCMH1 0.0037 0.0125 0.0125
Plasmodium falciparum ataxin-2 like protein, putative 0.0057 0.0226 0.424
Schistosoma mansoni intermediate filament proteins 0.0042 0.0152 0.0214
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0023 0.0053 0.0968
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0013 0.0002 0.0002
Toxoplasma gondii HEAT repeat-containing protein 0.0018 0.0027 0.0469
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0037 0.0125 0.0528
Loa Loa (eye worm) hypothetical protein 0.014 0.0657 0.0927
Echinococcus granulosus polycomb protein SCMH1 0.0037 0.0125 0.0504
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0043 0.0186
Loa Loa (eye worm) MH2 domain-containing protein 0.0373 0.1856 0.2619
Schistosoma mansoni cytochrome P450 0.0018 0.0028 0.004
Schistosoma mansoni cpg binding protein 0.0041 0.0146 0.0206
Schistosoma mansoni importin beta-1 0.0018 0.0027 0.0038
Trypanosoma brucei glycosyl hydrolase-like protein 0.0021 0.0043 0.0774
Schistosoma mansoni Smad4 0.0025 0.0064 0.0091
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.0015 0.001 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0042 0.0149 0.0171
Trypanosoma cruzi ISWI complex protein 0.0037 0.0126 0.235
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0059 0.024
Loa Loa (eye worm) hypothetical protein 0.0116 0.053 0.0747
Entamoeba histolytica hypothetical protein 0.0068 0.0281 0.5292
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0009 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0085 0.0372 0.0525
Brugia malayi cytoplasmic intermediate filament protein 0.0023 0.005 0.0227
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0015 0.001 0.0043
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0258 0.1261 0.178
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0013
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0068 0.0281 0.0281
Echinococcus granulosus mothers against decapentaplegic 5 0.0025 0.0064 0.026
Echinococcus multilocularis zinc finger protein 0.005 0.019 0.019
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0024 0.0059 0.0268
Mycobacterium tuberculosis Probable lipase LipE 0.0085 0.0372 0.0531
Leishmania major glycosyl hydrolase-like protein 0.0021 0.0043 0.0774
Brugia malayi cDNA sequence BC016226 0.0116 0.053 0.2386
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.1273 0.6489 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0013
Leishmania major 4-coumarate:coa ligase-like protein 0.0042 0.0149 0.2789
Schistosoma mansoni GTP-binding protein alpha subunit 0.0015 0.001 0.0013
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0116 0.053 1
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0023 0.0053 0.0968
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0116 0.053 1
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0013
Trichomonas vaginalis maltase-glucoamylase, putative 0.0057 0.0228 0.103
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0059 0.0059
Leishmania major hypothetical protein, conserved 0.0057 0.0226 0.424
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0116 0.053 0.0747
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.0015 0.001 0.001
Echinococcus granulosus GTP binding nuclear protein Ran 0.0013 0.0002 0.0009
Onchocerca volvulus Protein ultraspiracle homolog 0.0024 0.0059 0.0229
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0056 0.0222 0.0313
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.1389 0.7086 1
Brugia malayi Importin beta-1 subunit 0.0018 0.0027 0.0122
Brugia malayi latrophilin 2 splice variant baaae 0.0303 0.1496 0.6741
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0116 0.053 0.071
Loa Loa (eye worm) Smad1 0.0025 0.0064 0.0091
Brugia malayi MH2 domain containing protein 0.0025 0.0064 0.029
Echinococcus granulosus ecdysone induced protein 78C 0.0024 0.0059 0.024
Schistosoma mansoni aldehyde dehydrogenase 0.0092 0.0408 0.0576
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.2477 0.2477
Trichomonas vaginalis set domain proteins, putative 0.0439 0.2194 1
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0116 0.053 0.071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0024 0.0059 0.0084
Onchocerca volvulus 0.0302 0.1486 0.6759
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0116 0.053 0.0747
Loa Loa (eye worm) RNA binding protein 0.0091 0.0401 0.0566
Brugia malayi TAR-binding protein 0.0091 0.0401 0.1807
Loa Loa (eye worm) beta-lactamase 0.0085 0.0372 0.0525
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0023 0.0053 1
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0015 0.001 0.0033
Trypanosoma brucei hypothetical protein, conserved 0.0085 0.0372 0.7009
Trypanosoma cruzi ISWI complex protein 0.0037 0.0126 0.235
Loa Loa (eye worm) hypothetical protein 0.0197 0.0949 0.134
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0023 0.0053 0.0968
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0018 0.0028 0.0497
Brugia malayi beta-lactamase 0.0085 0.0372 0.1676
Brugia malayi hypothetical protein 0.0302 0.1486 0.6698
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0015 0.001 0.0033
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0085 0.0372 0.1676
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0021 0.0043 0.0186
Echinococcus multilocularis lamin dm0 0.0042 0.0152 0.0152
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0065 0.0091
Brugia malayi Glycosyl hydrolases family 31 protein 0.0057 0.0228 0.1028
Trichomonas vaginalis alpha-glucosidase, putative 0.0057 0.0228 0.103
Echinococcus granulosus zinc finger protein 0.005 0.019 0.0768
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0065 0.0065
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0024 0.0059 0.0229
Echinococcus granulosus geminin 0.045 0.2249 0.9079
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0056 0.0222 0.4162
Brugia malayi Pre-SET motif family protein 0.0056 0.0222 0.0999
Echinococcus granulosus methyl CpG binding domain protein 2 0.0042 0.0148 0.0599
Mycobacterium ulcerans D-amino acid oxidase Aao 0.1389 0.7086 1
Schistosoma mansoni inositol monophosphatase 0.0023 0.0053 0.0075
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0085 0.0372 0.0531
Leishmania major hypothetical protein, conserved 0.0116 0.053 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0024 0.0059 0.024
Echinococcus granulosus smad 0.0025 0.0064 0.026
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0021 0.0041 0.0019
Toxoplasma gondii histone lysine methyltransferase SET1 0.0074 0.0312 0.5875
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0031 0.0095 0.0094
Echinococcus granulosus histone lysine methyltransferase setb 0.0098 0.0437 0.1763
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0023 0.0053 0.0233
Echinococcus multilocularis expressed protein 0.0015 0.001 0.001
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0013 0.0002 0.0003
Schistosoma mansoni ferritin light chain 0.0019 0.0034 0.0048
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.0015 0.001 0.0013
Schistosoma mansoni survival motor neuron protein 0.004 0.0141 0.0198
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0024 0.0059 0.0084
Brugia malayi Nuclear hormone receptor-like 1 0.0024 0.0059 0.0268
Leishmania major hypothetical protein, conserved 0.0116 0.053 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0059 0.0084
Schistosoma mansoni ferritin light chain 0.0019 0.0034 0.0048
Schistosoma mansoni cpg binding protein 0.0035 0.0112 0.0158
Schistosoma mansoni smad 0.0025 0.0064 0.0091
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.0015 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0061
Brugia malayi Inositol-1 0.0023 0.0053 0.024
Schistosoma mansoni ferritin 0.0019 0.0034 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0344 0.1706 0.2408
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0013
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0042 0.0149 0.0171
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0024 0.0059 0.0268
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0024 0.0059 0.0059
Loa Loa (eye worm) hypothetical protein 0.0085 0.0372 0.0525
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0024 0.0059 0.0084
Entamoeba histolytica acyl-CoA synthetase, putative 0.0042 0.0149 0.2789
Schistosoma mansoni steroid hormone receptor ad4bp 0.0024 0.0059 0.0084
Loa Loa (eye worm) hypothetical protein 0.0031 0.0095 0.0134
Schistosoma mansoni zinc finger protein 0.005 0.019 0.0269
Onchocerca volvulus 0.0085 0.0372 0.1658
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0024 0.0059 0.0268
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0024 0.0059 0.0084
Brugia malayi cytochrome P450 0.0018 0.0028 0.0128
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0057 0.0228 0.103
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0015 0.001 0.0033
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0057 0.0228 0.103

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.1 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.2311 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 0.7375 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.8184 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 22.3872 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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