Detailed information for compound 144086

Basic information

Technical information
  • TDR Targets ID: 144086
  • Name: methyl (6R)-3-(3,4-dichlorophenyl)-6-hydroxy- 8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carbo xylate
  • MW: 342.217 | Formula: C16H17Cl2NO3
  • H donors: 1 H acceptors: 2 LogP: 2.57 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)C1=C(CC2N(C1[C@H](O)C2)C)c1ccc(c(c1)Cl)Cl
  • InChi: 1S/C16H17Cl2NO3/c1-19-9-6-10(8-3-4-11(17)12(18)5-8)14(16(21)22-2)15(19)13(20)7-9/h3-5,9,13,15,20H,6-7H2,1-2H3/t9?,13-,15?/m1/s1
  • InChiKey: NJIWTVLWXIINMO-KWCGZIOASA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6R)-3-(3,4-dichlorophenyl)-6-hydroxy-8-methyl-8-azabicyclo[3.2.1]oct-3-ene-4-carboxylic acid methyl ester

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0019 0.0008 0.0168
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0042 0.0399
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.0018 0.008
Mycobacterium tuberculosis Probable lipase LipD 0.0152 0.0134 0.0127
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0008 0.0037
Mycobacterium tuberculosis Probable reductase 0.0119 0.0103 0.0095
Brugia malayi nuclear receptor RXR 0.0011 0.0001 0.0007
Brugia malayi nuclear hormone receptor 0.0021 0.0011 0.0064
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0118 0.0707
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.0352 0.6857
Echinococcus multilocularis FTZ F1 alpha 0.0021 0.0011 0.0047
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0013 0.0003 0.0018
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.0014 0.0059
Schistosoma mansoni cpg binding protein 0.01 0.0085 0.0389
Echinococcus granulosus cathepsin l1 0.0013 0.0002 0.001
Loa Loa (eye worm) histone deacetylase 0.0053 0.0041 0.0245
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0012
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.0047
Plasmodium vivax amine transporter, putative 0.0062 0.0049 0.3645
Schistosoma mansoni blooms syndrome DNA helicase 0.001 0 0.0001
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0152 0.0134 0.0807
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0008 0.0017
Echinococcus multilocularis cpg binding protein 0.01 0.0085 0.0371
Schistosoma mansoni blooms syndrome DNA helicase 0.0011 0.0001 0.0002
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.001 0 0.0001
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Schistosoma mansoni carbonic anhydrase-related 0.1054 0.0987 0.4496
Trypanosoma brucei histone deacetylase, putative 0.0053 0.0041 0.0213
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0002 0.0045
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0134 0.261
Echinococcus multilocularis RUN 0.0042 0.003 0.0129
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.0134 0.0611
Giardia lamblia Kinase, CMGC MAPK 0.0054 0.0041 0.1194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0028 0.0167
Echinococcus multilocularis histone deacetylase 0.0053 0.0041 0.0177
Brugia malayi hypothetical protein 0.0463 0.0428 0.2574
Brugia malayi Cytochrome P450 family protein 0.0017 0.0007 0.0042
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1054 0.0987 0.5939
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Brugia malayi photoreceptor-specific nuclear receptor 0.0021 0.0011 0.0064
Echinococcus multilocularis Niemann Pick C1 protein 0.0099 0.0084 0.0364
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Plasmodium vivax glutathione reductase, putative 0.0052 0.004 0.295
Onchocerca volvulus 0.0152 0.0134 0.2749
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0009 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0131 0.0114 0.0495
Loa Loa (eye worm) hypothetical protein 0.0365 0.0336 0.2019
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.0007 0.0012
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0011 0.0001 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0064
Onchocerca volvulus 0.0027 0.0016 0.0319
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0011 0.0049
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0318
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0066 0.0053 0.0317
Schistosoma mansoni carbonic anhydrase-related 0.1054 0.0987 0.4496
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Loa Loa (eye worm) steroid hormone receptor 0.0021 0.0011 0.0064
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Toxoplasma gondii hypothetical protein 0.0062 0.0049 0.0495
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0064
Onchocerca volvulus 0.0152 0.0134 0.2749
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.0125 0.2426
Brugia malayi MH2 domain containing protein 0.0121 0.0105 0.0631
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0066 0.0053 0.024
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0041 0.0185
Leishmania major histone deacetylase, putative 0.0142 0.0125 0.072
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Toxoplasma gondii ABC1 family protein 0.0152 0.0134 0.1358
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0016 0.0009
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.003 0.0592
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Schistosoma mansoni ap endonuclease 0.004 0.0028 0.0128
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0011 0.0001 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0214 0.0975
Echinococcus multilocularis histone deacetylase 3 0.0142 0.0125 0.0542
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0016 0.0061
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1767 0.1662 1
Loa Loa (eye worm) histone methyltransferase 0.0031 0.002 0.012
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Trypanosoma brucei cytochrome P450, putative 0.0017 0.0007 0.0009
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.001 0.0044
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Mycobacterium ulcerans beta-lactamase 0.0152 0.0134 0.0127
Schistosoma mansoni hypothetical protein 0.0094 0.008 0.0363
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.001 0.0044
Schistosoma mansoni SET domain protein 0.0012 0.0002 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0064
Plasmodium vivax histone deacetylase, putative 0.0053 0.0041 0.3026
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.0007 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0011 0.0001 0.0022
Brugia malayi Metabotropic glutamate receptor precursor. 0.004 0.0029 0.0172
Brugia malayi Receptor family ligand binding region containing protein 0.001 0 0.0001
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0054 0.0041 0.0249
Echinococcus granulosus metabotropic glutamate receptor 5 0.005 0.0037 0.017
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0008 0.0036
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0028 0.0128
Brugia malayi hypothetical protein 0.0134 0.0117 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0008 0.0056
Loa Loa (eye worm) hypothetical protein 0.0028 0.0017 0.0102
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1767 0.1662 1
Brugia malayi ecdysteroid receptor 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Mycobacterium ulcerans hypothetical protein 0.0152 0.0134 0.0127
Echinococcus granulosus GPCR family 2 0.0066 0.0053 0.024
Onchocerca volvulus 0.0058 0.0046 0.0932
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0183
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Plasmodium vivax vivapain-2 0.0019 0.0008 0.0601
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0008 0.0037
Brugia malayi SET domain containing protein 0.0012 0.0002 0.0009
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1054 0.0987 0.5939
Entamoeba histolytica recQ family helicase, putative 0.0021 0.001 0.0351
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0016 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0152 0.0134 1
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Loa Loa (eye worm) hypothetical protein 0.0086 0.0072 0.0431
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Mycobacterium leprae Probable lipase LipE 0.0152 0.0134 0.0119
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.002 0.012
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0156 0.0138 0.0131
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0021 0.0011 0.0047
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.0202
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0008 0.028
Echinococcus granulosus intermediate filament protein 0.0058 0.0046 0.0207
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0054 0.0041 0.0217
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0007 0.0042
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Brugia malayi latrophilin 2 splice variant baaae 0.0142 0.0125 0.0751
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0008 0.0049
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0064
Plasmodium falciparum thioredoxin reductase 0.0018 0.0007 0.0049
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.003
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0026 0.0015 0.0063
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0064
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0495
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0062 0.0049 0.0213
Schistosoma mansoni hypothetical protein 0.0071 0.0058 0.0262
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Onchocerca volvulus Protein ultraspiracle homolog 0.0021 0.0011 0.0219
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0062 0.0049 0.0223
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0008 0.0168
Echinococcus granulosus mixed lineage leukemia protein mll 0.0026 0.0015 0.0066
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0007
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Echinococcus granulosus metabotropic glutamate receptor 2 0.0034 0.0022 0.0102
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0132 0.0116 0.0502
Brugia malayi Pre-SET motif family protein 0.0068 0.0055 0.033
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0011 0.0001 0.0007
Brugia malayi MAP kinase sur-1 0.0054 0.0041 0.0249
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0011 0.0001 0.0004
Brugia malayi hypothetical protein 0.0035 0.0024 0.0142
Brugia malayi Latrophilin receptor protein 2 0.0066 0.0053 0.0317
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0028 0.0549
Schistosoma mansoni mixed-lineage leukemia protein mll 0.02 0.018 0.0818
Onchocerca volvulus 0.0058 0.0046 0.0932
Mycobacterium tuberculosis Probable dehydrogenase 0.0119 0.0103 0.0095
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0028 0.0549
Echinococcus multilocularis GPCR, family 2 0.0066 0.0053 0.0229
Loa Loa (eye worm) hypothetical protein 0.0142 0.0125 0.0751
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Schistosoma mansoni RAR-like nuclear receptor 0.0021 0.0011 0.0049
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0064
Echinococcus multilocularis beta LACTamase domain containing family member 0.0152 0.0134 0.0583
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0021 0.0011 0.0064
Echinococcus granulosus carbonic anhydrase 0.1054 0.0987 0.4496
Schistosoma mansoni zinc finger protein 0.0016 0.0005 0.0025
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0054 0.0041 0.0246
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0054 0.0041 0.0418
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0031 0.002 0.0087
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0042 0.3118
Echinococcus granulosus histone deacetylase 6 0.0053 0.0041 0.0185
Schistosoma mansoni lamin 0.0058 0.0046 0.0207
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Onchocerca volvulus 0.0068 0.0055 0.1123
Plasmodium vivax histone deacetylase 1, putative 0.0142 0.0125 0.9292
Trichomonas vaginalis CMGC family protein kinase 0.0054 0.0041 0.0806
Brugia malayi metabotropic glutamate receptor type 2 0.002 0.0009 0.0054
Brugia malayi Cathepsin L-like precursor 0.0013 0.0002 0.0014
Trypanosoma brucei histone deacetylase 1 0.0142 0.0125 0.072
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0041 0.0185
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0119 0.0103 0.0095
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.001 0 0.0001
Leishmania major hypothetical protein, conserved 0.0054 0.0042 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0062 0.0049 0.0223
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0011 0.0001 0.0005
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0011 0.0001 0.0029
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0028 0.0729
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0011 0.0001 0.0005
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0011 0.0049
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.004 0.295
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.0007 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Plasmodium falciparum histone deacetylase, putative 0.0053 0.0041 0.0386
Brugia malayi hypothetical protein 0.0071 0.0058 0.0346
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Loa Loa (eye worm) RNA binding protein 0.0131 0.0114 0.0685
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0034
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0028 1
Toxoplasma gondii histone deacetylase HDAC4 0.0053 0.0041 0.0411
Onchocerca volvulus Glucosylceramidase homolog 0.0363 0.0334 0.6841
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0347
Loa Loa (eye worm) hypothetical protein 0.0073 0.006 0.036
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0132 0.0116 0.0108
Echinococcus multilocularis transcription factor Dp 1 0.0078 0.0064 0.0279
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0021 0.0011 0.0064
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Echinococcus multilocularis musashi 0.0058 0.0046 0.0198
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1054 0.0987 0.5939
Loa Loa (eye worm) hypothetical protein 0.004 0.0028 0.0169
Giardia lamblia Fructose-bisphosphate aldolase 0.0319 0.0292 1
Onchocerca volvulus Huntingtin homolog 0.0134 0.0117 0.2391
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0208 0.0187 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.0134 0.0805
Echinococcus multilocularis bloom syndrome protein 0.0021 0.001 0.0044
Schistosoma mansoni metabotropic glutamate receptor 0.002 0.0009 0.0041
Echinococcus granulosus Niemann Pick C1 protein 0.0099 0.0084 0.0381
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1054 0.0987 0.5939
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0554 0.0514 0.3093
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0156 0.0138 0.013
Plasmodium vivax hypothetical protein, conserved 0.0062 0.0049 0.3645
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.0049
Loa Loa (eye worm) solute carrier family 6 member 4 0.0365 0.0336 0.2019
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Schistosoma mansoni intermediate filament proteins 0.0058 0.0046 0.0207
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.004 0.0172
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1767 0.1662 1
Brugia malayi Histone deacetylase family protein 0.0053 0.0041 0.0245
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0008 0.0168
Echinococcus granulosus sodium and chloride dependent glycine 0.0062 0.0049 0.0223
Onchocerca volvulus 0.0062 0.0049 0.1004
Brugia malayi PHD-finger family protein 0.0031 0.002 0.012
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0012
Plasmodium vivax SET domain protein, putative 0.0068 0.0055 0.4079
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.001 0.0062
Schistosoma mansoni histone deacetylase 0.0142 0.0125 0.0568
Brugia malayi Histone deacetylase 1 0.0142 0.0125 0.075
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Echinococcus multilocularis thyroid hormone receptor alpha 0.0021 0.0011 0.0047
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0495
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Loa Loa (eye worm) RecQ helicase 0.0021 0.001 0.0062
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0008 0.0036
Leishmania major trypanothione reductase 0.0052 0.004 0.0207
Loa Loa (eye worm) hypothetical protein 0.0054 0.0042 0.0252
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Brugia malayi histone deacetylase 1 (HD1) 0.0142 0.0125 0.075
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.003 0.0135
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Echinococcus multilocularis dnaJ subfamily B 0.1327 0.1245 0.5409
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus multilocularis mitogen activated protein kinase 0.0054 0.0041 0.018
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Loa Loa (eye worm) TAR-binding protein 0.0131 0.0114 0.0685
Echinococcus multilocularis Niemann Pick C1 protein 0.0141 0.0124 0.0538
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0116 0.0109
Schistosoma mansoni DNA helicase recq1 0.0021 0.001 0.0047
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0016 0.0061
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0066 0.0053 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Schistosoma mansoni tar DNA-binding protein 0.0131 0.0114 0.0519
Toxoplasma gondii histone deacetylase HDAC5 0.0053 0.0041 0.0411
Mycobacterium leprae conserved hypothetical protein 0.0152 0.0134 0.0119
Treponema pallidum sodium- and chloride- dependent transporter 0.0365 0.0336 1
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.0018 0.0076
Echinococcus multilocularis lamin dm0 0.0058 0.0046 0.0198
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0132 0.0116 0.0665
Loa Loa (eye worm) histone deacetylase 7A 0.0053 0.0041 0.0245
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.0007 0.0074
Loa Loa (eye worm) histone deacetylase 11 0.0053 0.0041 0.0245
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0001
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0011 0.0064
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.003 0.0139
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0007 0.0033
Trypanosoma cruzi histone deacetylase 1, putative 0.0142 0.0125 0.0747
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.003 0.0129
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0001 0.0022
Trypanosoma brucei trypanothione reductase 0.0052 0.004 0.0207
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Loa Loa (eye worm) beta-lactamase 0.0152 0.0134 0.0807
Schistosoma mansoni hypothetical protein 0.0016 0.0005 0.0025
Echinococcus granulosus mitogen activated protein kinase 0.0054 0.0041 0.0189
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0062
Schistosoma mansoni cpg binding protein 0.01 0.0085 0.0389
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Loa Loa (eye worm) hypothetical protein 0.0019 0.0008 0.0049
Echinococcus multilocularis carbonic anhydrase 0.1054 0.0987 0.4287
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0062
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0066 0.0053 0.0317
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Plasmodium falciparum LCCL domain-containing protein 0.0042 0.003 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0021 0.0011 0.0064
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Brugia malayi CXXC zinc finger family protein 0.0093 0.0079 0.0472
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.0007 0.0074
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0214 0.0975
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.0007 0.0548
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0021 0.0011 0.0064
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Schistosoma mansoni hypothetical protein 0.0024 0.0014 0.0062
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0065 0.0052 0.0312
Plasmodium vivax histone deacetylase, putative 0.0053 0.0041 0.3026
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0016 0.0008
Echinococcus multilocularis metabotropic glutamate receptor 5 0.005 0.0037 0.0162
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0016 0.0534
Giardia lamblia Histone deacetylase 0.0142 0.0125 0.4123
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0132 0.0116 0.0527
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.0047
Echinococcus multilocularis histone deacetylase 7 0.0053 0.0041 0.0177
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0029
Onchocerca volvulus 0.0152 0.0134 0.2749
Brugia malayi TAR-binding protein 0.0131 0.0114 0.0685
Schistosoma mansoni lipoxygenase 0.0248 0.0225 0.1027
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0225
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0119 0.0103 0.0095
Mycobacterium ulcerans lipase LipD 0.0152 0.0134 0.0127
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0135 0.0118 0.071
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.0018 0.008
Brugia malayi Bromodomain containing protein 0.004 0.0028 0.0169
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.001 0.0202
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0016 0.0009
Echinococcus granulosus lamin 0.0058 0.0046 0.0207
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.0007 0.0001
Onchocerca volvulus 0.0012 0.0002 0.0031
Schistosoma mansoni hypothetical protein 0.0142 0.0125 0.0569
Schistosoma mansoni lipoxygenase 0.0174 0.0155 0.0705
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0034
Schistosoma mansoni sodium-dependent amino acid transporter 0.0062 0.0049 0.0223
Onchocerca volvulus 0.0042 0.003 0.0608
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Schistosoma mansoni myst-related protein 0.0013 0.0003 0.0012
Echinococcus multilocularis geminin 0.0874 0.0817 0.3546
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0135 0.0118 0.071
Trypanosoma brucei hypothetical protein, conserved 0.0152 0.0134 0.0777
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.002 0.012
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0008 0.0036
Loa Loa (eye worm) hypothetical protein 0.0053 0.0041 0.0245
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0067 0.0054 0.0235
Schistosoma mansoni lamin 0.0058 0.0046 0.0207
Echinococcus multilocularis histone deacetylase 8 0.0053 0.0041 0.0177
Schistosoma mansoni histone deacetylase hda2 0.0053 0.0041 0.0185
Toxoplasma gondii histone deacetylase HDAC1 0.0053 0.0041 0.0411
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0062 0.0049 0.0223
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.0007 0.0049
Trichomonas vaginalis histone deacetylase, putative 0.0142 0.0125 0.2426
Treponema pallidum fructose-bisphosphate aldolase 0.0319 0.0292 0.8692
Echinococcus granulosus bloom syndrome protein 0.0021 0.001 0.0047
Echinococcus granulosus survival motor neuron protein 1 0.0463 0.0428 0.1949
Echinococcus multilocularis cysteine protease 0.0019 0.0008 0.0036
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1767 0.1662 0.757
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0068 0.0055 0.0554
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0054 0.0041 0.0217
Loa Loa (eye worm) glutathione reductase 0.0052 0.004 0.0239
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0152 0.0134 0.0127
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0016 0.0534
Brugia malayi glutathione reductase 0.0052 0.004 0.0239
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0094 0.008 0.0479
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.001 0.0199
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0016 0.0094
Schistosoma mansoni carbonic anhydrase 0.1054 0.0987 0.4496
Leishmania major histone deacetylase, putative 0.0142 0.0125 0.072
Mycobacterium ulcerans AcrR family transcriptional regulator 1.0583 1 1
Onchocerca volvulus 0.0526 0.0488 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni niemann-pick C1 (NPC1) 0.01 0.0085 0.0388
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.001 0 0.0001
Schistosoma mansoni hypothetical protein 0.0874 0.0817 0.372
Toxoplasma gondii hypothetical protein 0.1054 0.0987 1
Schistosoma mansoni cpg binding protein 0.0093 0.0079 0.0358
Loa Loa (eye worm) hypothetical protein 0.0134 0.0117 0.0702
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0118 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni bromodomain containing protein 0.0071 0.0058 0.0262
Loa Loa (eye worm) intermediate filament protein 0.0058 0.0046 0.0274
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0016 0.0009
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0042 0.022
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Echinococcus granulosus Polycystic kidney disease protein 0.0042 0.003 0.0135
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.004 0.0032
Echinococcus granulosus histone deacetylase 6 0.0053 0.0041 0.0185
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus granulosus histone deacetylase 8 0.0053 0.0041 0.0185
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0028 0.0123
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0152 0.0134 0.0127
Brugia malayi nuclear receptor NHR-88 0.0021 0.0011 0.0064
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0463 0.0428 0.2575
Onchocerca volvulus 0.0019 0.0008 0.0168
Brugia malayi Histone deacetylase family protein 0.0053 0.0041 0.0245
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0028 0.0967
Schistosoma mansoni retinoic acid receptor RXR 0.0021 0.0011 0.0049
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0021 0.0011 0.0049
Brugia malayi beta-lactamase family protein 0.0152 0.0134 0.0807
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.001 0.0047
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0042 0.0399
Brugia malayi CHE-14 protein 0.0042 0.003 0.0183
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0007 0.0033
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0041 0.0177
Onchocerca volvulus 0.0019 0.0008 0.0168
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0094
Trichomonas vaginalis esterase, putative 0.0152 0.0134 0.261
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0248 0.0225 0.0979
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.001 0.0077
Brugia malayi Calcitonin receptor-like protein seb-1 0.0208 0.0187 0.1126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0002 0.0045
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0021 0.0011 0.0049
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0016 0.0009
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0009 0.0066
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Echinococcus granulosus histone deacetylase 1 0.0142 0.0125 0.0568
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Brugia malayi Steroid receptor seven-up type 2 0.0021 0.0011 0.0064
Echinococcus granulosus Protein patched homolog 1 0.0042 0.003 0.0139
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0152 0.0134 0.0611
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0086 0.0072 0.0311
Echinococcus granulosus ecdysone induced protein 78C 0.0021 0.0011 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0016 0.0009
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0016 0.0061
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0021 0.0011 0.0049
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0051 0.023
Echinococcus granulosus microtubule associated protein 2 0.2331 0.2195 1
Schistosoma mansoni hypothetical protein 0.0042 0.003 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0068 0.0055 0.025
Onchocerca volvulus 0.0042 0.003 0.0608
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.0292 1
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0116 0.0527
Brugia malayi Doublecortin family protein 0.0042 0.003 0.0179
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0008 0.0037
Echinococcus granulosus lamin dm0 0.0058 0.0046 0.0207
Loa Loa (eye worm) histone deacetylase 1 0.0142 0.0125 0.075
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.0125 0.2426
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0094
Echinococcus granulosus FTZ F1 alpha 0.0021 0.0011 0.0049
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.0007 0.0012
Schistosoma mansoni thyroid hormone receptor 0.0021 0.0011 0.0049
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0072 0.0326
Toxoplasma gondii thioredoxin reductase 0.0052 0.004 0.0401
Loa Loa (eye worm) hypothetical protein 0.0365 0.0336 0.2019
Loa Loa (eye worm) histone deacetylase 3 0.0142 0.0125 0.075
Mycobacterium tuberculosis Probable esterase LipL 0.0152 0.0134 0.0127
Echinococcus granulosus sodium and chloride dependent glycine 0.0062 0.0049 0.0223
Loa Loa (eye worm) hypothetical protein 0.0057 0.0045 0.0268
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0041 0.0177
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.0134 0.261
Loa Loa (eye worm) hypothetical protein 0.0134 0.0117 0.0702
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0059
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0016 0.0008
Loa Loa (eye worm) ctsf protein 0.0019 0.0008 0.0049
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0008 0.0056
Leishmania major histone deacetylase, putative 0.0053 0.0041 0.0213
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0142 0.0125 0.2426
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0067 0.0054 0.0246
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0021 0.0011 0.0049
Echinococcus granulosus histone deacetylase 6 0.0053 0.0041 0.0185
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0028 0.017
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0042 0.0249
Schistosoma mansoni zinc finger protein 0.0026 0.0015 0.0067
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0009 0.0419
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0009 0.0678
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Plasmodium falciparum transporter, putative 0.0062 0.0049 0.0471
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0119 0.0103 0.0095
Brugia malayi hypothetical protein 0.0011 0.0001 0.0007
Plasmodium falciparum carbonic anhydrase 0.1054 0.0987 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0028 0.0021
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0026 0.0015 0.0063
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0134 0.261
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0016 0.0534
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.003 0.0132
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Loa Loa (eye worm) hypothetical protein 0.0058 0.0046 0.0274
Brugia malayi Thioredoxin reductase 0.0052 0.004 0.0239
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0012
Echinococcus granulosus zinc finger protein 0.0026 0.0015 0.0067
Loa Loa (eye worm) CXXC zinc finger family protein 0.0093 0.0079 0.0472
Echinococcus multilocularis expressed conserved protein 0.0093 0.0078 0.0339
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Onchocerca volvulus 0.0365 0.0336 0.6874
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0021 0.0011 0.0064
Entamoeba histolytica hypothetical protein 0.0013 0.0003 0.0091
Echinococcus multilocularis carbonic anhydrase 0.1054 0.0987 0.4287
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.001 0.0097
Echinococcus multilocularis carbonic anhydrase II 0.1767 0.1662 0.7218
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0039 0.0237
Brugia malayi histone deacetylase 3 (HD3) 0.0142 0.0125 0.075
Loa Loa (eye worm) hypothetical protein 0.005 0.0037 0.0225
Leishmania major cytochrome p450-like protein 0.0017 0.0007 0.0009
Echinococcus granulosus RUN 0.0042 0.003 0.0135
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0064
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.0007 0.0045
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0037 0.0025 0.015
Echinococcus granulosus cathepsin l1 0.0019 0.0008 0.0037
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0183
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0042 0.0424
Leishmania major cathepsin L-like protease 0.0072 0.0058 0.0318
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0002 0.0079
Brugia malayi hypothetical protein 0.0062 0.0049 0.0295
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0016 0.0009
Schistosoma mansoni coup transcription factor 0.0021 0.0011 0.0049
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0026 0.0117
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Echinococcus multilocularis carbonic anhydrase 0.1054 0.0987 0.4287
Plasmodium falciparum histone deacetylase 2 0.0053 0.0041 0.0386
Trichomonas vaginalis glucosylceramidase, putative 0.0383 0.0352 0.6857
Schistosoma mansoni hypothetical protein 0.1327 0.1245 0.5673
Echinococcus granulosus expressed conserved protein 0.0093 0.0078 0.0356
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0236 0.0214 0.1288
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0319 0.0292 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Trichomonas vaginalis set domain proteins, putative 0.0526 0.0488 0.9497
Echinococcus multilocularis sodium and chloride dependent glycine 0.0062 0.0049 0.0213
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.004 0.0236
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0094
Loa Loa (eye worm) hypothetical protein 0.002 0.0009 0.0055
Schistosoma mansoni serine/threonine protein kinase 0.0054 0.0041 0.0189
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0015 0.0066
Trichomonas vaginalis glucosylceramidase, putative 0.0554 0.0514 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.0187 0.1126
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0055 0.025
Schistosoma mansoni sodium/chloride dependent transporter 0.0062 0.0049 0.0225
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.0007 0.0012
Treponema pallidum NADH oxidase 0.0018 0.0007 0.0208
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0011 0.0064
Trypanosoma cruzi major cysteine proteinase, putative 0.0056 0.0044 0.026
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Echinococcus granulosus mitogen activated protein kinase 3 0.0054 0.0041 0.0189
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1054 0.0987 0.5939
Schistosoma mansoni nuclear hormone receptor 0.0021 0.0011 0.0049
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.004 0.0181
Mycobacterium ulcerans transcriptional regulator 1.0583 1 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.0007 0.0012
Onchocerca volvulus Huntingtin homolog 0.0134 0.0117 0.2391
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0054 0.0041 0.0246
Echinococcus granulosus histone deacetylase 0.0053 0.0041 0.0185
Schistosoma mansoni microtubule-associated protein tau 0.2331 0.2195 1
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0028 0.0827
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0008 0.0056
Trichomonas vaginalis penicillin-binding protein, putative 0.0152 0.0134 0.261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0021 0.0011 0.0064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0062 0.0049 0.0223
Brugia malayi Intermediate filament tail domain containing protein 0.0058 0.0046 0.0274
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.001 0.0199
Schistosoma mansoni myst-related protein 0.0013 0.0003 0.0012
Plasmodium vivax multidomain scavenger receptor, putative 0.0042 0.003 0.2205
Schistosoma mansoni sodium/chloride dependent transporter 0.0062 0.0049 0.0223
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0046 0.0034 0.0154
Mycobacterium tuberculosis Probable lipase LipE 0.0152 0.0134 0.0127
Onchocerca volvulus 0.0019 0.0008 0.0168
Mycobacterium tuberculosis Conserved protein 0.0152 0.0134 0.0127
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Echinococcus multilocularis protein dispatched 1 0.0048 0.0036 0.0157
Brugia malayi Pre-SET motif family protein 0.0463 0.0428 0.2575
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0008 0.0159
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0554 0.0514 0.3093
Mycobacterium tuberculosis Conserved protein 0.0152 0.0134 0.0127
Brugia malayi Cytochrome P450 family protein 0.0017 0.0007 0.0042
Trypanosoma brucei protein kinase, putative 0.0054 0.0041 0.0217
Schistosoma mansoni rab6-interacting 0.0042 0.003 0.0135
Mycobacterium ulcerans esterase/lipase LipP 0.0152 0.0134 0.0127
Toxoplasma gondii exonuclease III APE 0.004 0.0028 0.0285
Plasmodium falciparum glutathione reductase 0.0052 0.004 0.0376
Plasmodium vivax vivapain-2 0.0019 0.0008 0.0601
Loa Loa (eye worm) CYP4Cod1 0.0017 0.0007 0.0042
Mycobacterium tuberculosis Probable hydrolase 0.0152 0.0134 0.0127
Echinococcus multilocularis ecdysone induced protein 78C 0.0021 0.0011 0.0047
Loa Loa (eye worm) carbonic anhydrase 3 0.1767 0.1662 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0021 0.0011 0.0049
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Entamoeba histolytica cysteine protease, putative 0.0019 0.0008 0.028
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0007 0.0042
Brugia malayi hypothetical protein 0.0042 0.003 0.0179
Schistosoma mansoni polycystin 1-related 0.0042 0.003 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0064
Loa Loa (eye worm) glutamate receptor 0.0016 0.0005 0.0032
Loa Loa (eye worm) serotonin transporter b 0.0365 0.0336 0.2019
Echinococcus multilocularis mitogen activated protein kinase 3 0.0054 0.0041 0.018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.2445 0.2302 1
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.0105 0.0631
Plasmodium falciparum glutathione reductase 0.0018 0.0007 0.0049
Schistosoma mansoni histone deacetylase 1 2 3 0.0053 0.0041 0.0185
Echinococcus multilocularis protein patched 0.0042 0.003 0.0132
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.001 0.0047
Mycobacterium tuberculosis Probable oxidoreductase 0.0132 0.0115 0.0108
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Echinococcus multilocularis lamin 0.0058 0.0046 0.0198
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.0047
Leishmania major cathepsin L-like protease 0.0019 0.0008 0.0017
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0062 0.0049 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0031 0.002 0.0091
Brugia malayi hypothetical protein 0.0054 0.0042 0.0252
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0365 0.0336 0.2019
Brugia malayi beta-lactamase family protein 0.0152 0.0134 0.0807
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.001 0.0199
Schistosoma mansoni steroid hormone receptor ad4bp 0.0021 0.0011 0.0049
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0021 0.0129
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0214 0.0929
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0119 0.0103 0.0087
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0016 0.0094
Echinococcus granulosus lipoxygenase domain containing protein 0.0042 0.003 0.0135
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0208 0.0187 0.1126
Entamoeba histolytica hypothetical protein 0.0071 0.0058 0.1972
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0021 0.0011 0.0049
Leishmania major hypothetical protein, conserved 0.0152 0.0134 0.0777
Toxoplasma gondii cathepsin CPL 0.0019 0.0008 0.0082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0021 0.0011 0.0064
Echinococcus multilocularis zinc finger protein 0.0026 0.0015 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.001 0.0202
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0116 0.0109
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0132 0.0115 0.01
Onchocerca volvulus 0.0021 0.0011 0.0219
Trichomonas vaginalis hypothetical protein 0.0011 0.0001 0.0022
Echinococcus multilocularis histone deacetylase 1 0.0142 0.0125 0.0542
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.001 0.0077
Loa Loa (eye worm) glutamate receptor 0.004 0.0029 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0152 0.0134 0.261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Toxoplasma gondii histone deacetylase HDAC2 0.0142 0.0125 0.1262
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0002 0.0014
Brugia malayi N-terminal motif family protein 0.0199 0.0179 0.1074
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0131 0.0114 0.0685
Trypanosoma cruzi cruzipain precursor, putative 0.0072 0.0058 0.0347
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0021 0.0011 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0152 0.0134 0.0805
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0152 0.0134 0.0807
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0041 0.0246
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.1054 0.0987 0.5939
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Loa Loa (eye worm) hypothetical protein 0.0199 0.0179 0.1074
Onchocerca volvulus 0.0062 0.0049 0.1004
Echinococcus granulosus histone deacetylase 3 0.0142 0.0125 0.0568
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.0058 0.025
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.0007 0.0145
Echinococcus granulosus serotonin transporter 0.0365 0.0336 0.1529
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Echinococcus granulosus dnaJ subfamily B 0.1327 0.1245 0.5673
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0066 0.0053 0.024
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1767 0.1662 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0099 0.0084 0.287
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Loa Loa (eye worm) hypothetical protein 0.0365 0.0336 0.2019
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0008 0.0046
Schistosoma mansoni hypothetical protein 0.0066 0.0053 0.024
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0236 0.0214 0.0929
Schistosoma mansoni hypothetical protein 0.1054 0.0987 0.4496
Brugia malayi beta-lactamase 0.0152 0.0134 0.0807
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0062 0.0049 0.0223
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0132 0.0115 0.0108
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0135 0.0118 0.0513
Echinococcus granulosus transcription factor Dp 1 0.0078 0.0064 0.0293
Echinococcus granulosus carbonic anhydrase 0.1054 0.0987 0.4496
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.004 0.0239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0086 0.0072 0.0326
Toxoplasma gondii histone deacetylase HDAC3 0.0142 0.0125 0.1262
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0008 0.0049
Toxoplasma gondii histone lysine methyltransferase SET1 0.0181 0.0162 0.164
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0021 0.0011 0.0049
Schistosoma mansoni ap endonuclease 0.004 0.0028 0.0128
Mycobacterium tuberculosis Conserved protein 0.0152 0.0134 0.0127
Schistosoma mansoni sodium/chloride dependent transporter 0.0365 0.0336 0.1529
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.0007 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0026 0.0112
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0021 0.0011 0.0219
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1767 0.1662 0.757
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1767 0.1662 1
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Trypanosoma brucei histone deacetylase 4 0.0053 0.0041 0.0213
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.0007 0.0001
Echinococcus multilocularis survival motor neuron protein 1 0.0463 0.0428 0.1858
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Brugia malayi RNA recognition motif domain containing protein 0.0131 0.0114 0.0685
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0008 0.0001
Trichomonas vaginalis helicase, putative 0.0021 0.001 0.0202
Echinococcus granulosus Niemann Pick C1 protein 0.0141 0.0124 0.0564
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0152 0.0134 0.0127
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Echinococcus multilocularis serotonin transporter 0.0365 0.0336 0.1458
Loa Loa (eye worm) hypothetical protein 0.1054 0.0987 0.5939
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0214 0.0975
Trypanosoma cruzi histone deacetylase 1, putative 0.0142 0.0125 0.0747
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0179
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0013 0.0003 0.0018
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0005 0.0024
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Schistosoma mansoni histone deacetylase 4 5 0.0053 0.0041 0.0185
Loa Loa (eye worm) hypothetical protein 0.0152 0.0134 0.0807
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.0007 0.0012
Toxoplasma gondii aldehyde dehydrogenase 0.0132 0.0116 0.1171
Plasmodium falciparum thioredoxin reductase 0.0052 0.004 0.0376
Loa Loa (eye worm) hypothetical protein 0.1054 0.0987 0.5939
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.0014 0.0062
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.0058 0.0262
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0008 0.0036
Echinococcus granulosus cpg binding protein 0.01 0.0085 0.0389
Loa Loa (eye worm) doublecortin family protein 0.0042 0.003 0.0179
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0021 0.0011 0.0064
Echinococcus multilocularis microtubule associated protein 2 0.2331 0.2195 0.9535
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0135 0.0118 0.0538
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0008 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0007
Plasmodium vivax histone deacetylase 2, putative 0.0053 0.0041 0.3026
Plasmodium falciparum histone deacetylase 1 0.0142 0.0125 0.124
Brugia malayi Niemann-Pick C1 protein precursor 0.0099 0.0084 0.0504
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.001 0.0062
Mycobacterium ulcerans aldehyde dehydrogenase 0.0132 0.0116 0.0109
Loa Loa (eye worm) hypothetical protein 0.0011 0.0001 0.0003
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0028 0.017
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0135 0.0118 0.0707
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Brugia malayi histone deacetylase 11 0.0053 0.0041 0.0245
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0021 0.0011 0.0049
Echinococcus granulosus beta LACTamase domain containing family member 0.0152 0.0134 0.0611
Brugia malayi Nuclear hormone receptor-like 1 0.0011 0.0001 0.0007
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0159
Trypanosoma cruzi cysteine peptidase, putative 0.0072 0.0058 0.0347
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0152 0.0134 0.0127
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0062 0.0049 0.0295
Schistosoma mansoni aldehyde dehydrogenase 0.0132 0.0116 0.0527
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0021 0.0011 0.0064
Schistosoma mansoni metabotropic glutamate receptor 0.0034 0.0022 0.0102
Leishmania major histone deacetylase, putative 0.0053 0.0041 0.0213
Schistosoma mansoni carbonic anhydrase-related 0.1054 0.0987 0.4496
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0236 0.0214 0.0975
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0007 0.0033
Echinococcus multilocularis cysteine protease 0.0019 0.0008 0.0036
Onchocerca volvulus 0.0094 0.008 0.1631
Echinococcus granulosus tar DNA binding protein 0.0131 0.0114 0.0519
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0028 0.0259
Mycobacterium ulcerans hypothetical protein 0.0027 0.0016 0.0009
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Schistosoma mansoni hypothetical protein 0.0874 0.0817 0.372
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0014
Loa Loa (eye worm) fibroinase 0.0019 0.0008 0.0049
Onchocerca volvulus 0.0019 0.0008 0.0168
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0365 0.0336 0.1529
Trypanosoma cruzi histone deacetylase, putative 0.0053 0.0041 0.0242
Loa Loa (eye worm) hypothetical protein 0.0142 0.0125 0.075
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0021 0.0011 0.0047
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0058 0.0046 0.0274
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0028 0.0167
Mycobacterium tuberculosis Transcriptional regulatory repressor protein (TetR-family) EthR 1.0583 1 1
Brugia malayi Cathepsin L-like precursor 0.0019 0.0008 0.0049
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0017 0.0074
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0017 0.0077
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0008 0.0168
Onchocerca volvulus 0.0013 0.0002 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.003 0.0179
Brugia malayi Cathepsin L-like precursor 0.0013 0.0002 0.0014
Loa Loa (eye worm) hypothetical protein 0.0463 0.0428 0.2574
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0062 0.0049 0.0213
Toxoplasma gondii hypothetical protein 0.0062 0.0049 0.0495
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0008 0.0047
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0026 0.0015 0.0066
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0021 0.0011 0.0049
Loa Loa (eye worm) hypothetical protein 0.0062 0.0049 0.0295
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0135 0.0118 0.4046
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0096
Onchocerca volvulus Histone deacetylase 10 homolog 0.0053 0.0041 0.0833
Echinococcus granulosus histone deacetylase 7 0.0053 0.0041 0.0185
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.1054 0.0987 0.5939
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0054 0.0041 0.0246
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0068 0.0055 0.0238
Echinococcus granulosus carbonic anhydrase 0.1054 0.0987 0.4496
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0028 0.0138
Trypanosoma cruzi ISWI complex protein 0.0016 0.0005 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0008 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.0363 0.0334 0.6497
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0236 0.0214 0.1288
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0319 0.0292 0.5676
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0156 0.0138 0.0122
Loa Loa (eye worm) cytochrome P450 family protein 0.0017 0.0007 0.0042
Echinococcus multilocularis sodium and chloride dependent glycine 0.0062 0.0049 0.0213
Mycobacterium ulcerans fatty-acid-CoA ligase 0.002 0.0009 0.0002
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0064
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0066 0.0053 0.0229
Onchocerca volvulus 0.0093 0.0079 0.1608
Loa Loa (eye worm) hypothetical protein 0.0099 0.0084 0.0504
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0495
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.001 0.0029
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0007 0.0038
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0062 0.0049 0.0213
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0007 0.0031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0028 0.2095
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0062 0.0049 0.0223
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0008 0.0049
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.0007 0.0049
Brugia malayi hypothetical protein 0.0011 0.0001 0.0007
Entamoeba histolytica histone deacetylase, putative 0.0142 0.0125 0.4274
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0034 0.0022 0.0097
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0135 0.0118 0.068
Brugia malayi hypothetical protein 0.0042 0.003 0.0179
Schistosoma mansoni rab6-interacting 0.0042 0.003 0.0135
Loa Loa (eye worm) cysteine protease 0.0019 0.0008 0.0049
Echinococcus granulosus histone lysine methyltransferase setb 0.0086 0.0072 0.0326
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.0007 0.0042
Brugia malayi steroid hormone receptor 0.0021 0.0011 0.0064
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0062
Schistosoma mansoni loxhd1 0.0042 0.003 0.0135
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0028 0.0021
Schistosoma mansoni patched 1 0.0042 0.003 0.0139
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0021 0.0011 0.0047
Brugia malayi cathepsin L-like precursor 0.0013 0.0002 0.0014
Echinococcus multilocularis lipoxygenase domain containing protein 0.0042 0.003 0.0129
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.0007 0.0548
Schistosoma mansoni hypothetical protein 0.0041 0.0029 0.0132
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.0058 0.0262
Loa Loa (eye worm) hypothetical protein 0.0027 0.0016 0.0096
Brugia malayi Bromodomain containing protein 0.0083 0.0069 0.0416
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.001 0.0102
Loa Loa (eye worm) hypothetical protein 0.0066 0.0053 0.0317
Onchocerca volvulus 0.0062 0.0049 0.1004
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0199 0.0179 0.3657
Trypanosoma cruzi cytochrome P450, putative 0.0017 0.0007 0.0038
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0028 0.0138
Onchocerca volvulus 0.0019 0.0008 0.0168
Entamoeba histolytica recQ family helicase, putative 0.001 0 0.0004
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0248 0.0225 0.1027
Trypanosoma brucei histone deacetylase 2 0.0053 0.0041 0.0213
Echinococcus granulosus carbonic anhydrase II 0.1767 0.1662 0.757
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.003 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0021 0.001 0.0202
Schistosoma mansoni hypothetical protein 0.0021 0.0011 0.0049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0971 0.0909 0.0902
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.0105 0.0631
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0008 0.028
Entamoeba histolytica recQ family DNA helicase 0.0011 0.0001 0.0017
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0236 0.0214 0.0975
Trypanosoma brucei carbonic anhydrase-like protein 0.1767 0.1662 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0119 0.0103 0.0095
Trypanosoma brucei histone deacetylase 3 0.0053 0.0041 0.0213
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0042 0.0249
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0072 0.0058 0.0318
Echinococcus multilocularis Polycystic kidney disease protein 0.0042 0.003 0.0129
Schistosoma mansoni DNA helicase recq5 0.0021 0.001 0.0047
Schistosoma mansoni histone deacetylase 0.0142 0.0125 0.0568
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0062 0.0049 0.0295
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0135 0.0118 0.0538
Leishmania major carbonic anhydrase-like protein 0.1767 0.1662 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0132 0.0115 0.0108
Onchocerca volvulus 0.0019 0.0008 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0008 0.0159
Brugia malayi intermediate filament protein 0.0058 0.0046 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0021 0.0011 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0021 0.0011 0.0064
Loa Loa (eye worm) norepinephrine transporter 0.0365 0.0336 0.2019
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0016 0.0094
Echinococcus multilocularis histone deacetylase 6 0.0053 0.0041 0.0177
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0054 0.0041 0.0217
Plasmodium falciparum amino acid transporter, putative 0.0062 0.0049 0.0471
Echinococcus granulosus geminin 0.0874 0.0817 0.372
Onchocerca volvulus Bile acid receptor homolog 0.0021 0.0011 0.0219
Mycobacterium ulcerans TetR family transcriptional regulator 1.0583 1 1
Brugia malayi RNA binding protein 0.0131 0.0114 0.0685
Schistosoma mansoni survival motor neuron protein 0.0094 0.008 0.0363
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0002 0.001

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 7.37 nM Inhibition of [3H]-WIN- 35428 binding to Dopamine transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen ChEMBL. 11472216
IC50 (binding) = 19.4 nM Inhibition of [3H]-WIN- 35428 binding to Dopamine transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen ChEMBL. 11472216
IC50 (binding) = 19.4 nM Inhibition of [3H]-WIN- 35428 binding to Dopamine transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen ChEMBL. 11472216
IC50 (binding) = 5370 nM Inhibition of [3H]-citalopram binding to the serotonin transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen. ChEMBL. 11472216
IC50 (binding) > 6000 nM Inhibition of [3H]-citalopram binding to the serotonin transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen. ChEMBL. 11472216
IC50 (binding) > 6000 nM Inhibition of [3H]-citalopram binding to the serotonin transporter in rhesus (Macaca mulatta) or cynomolgus monkey (Macaca fascicularis) caudate-putamen. ChEMBL. 11472216
Ratio (binding) > 300 SERT/DAT ratio of the compound ChEMBL. 11472216
Ratio (binding) = 730 SERT/DAT ratio of the compound ChEMBL. 11472216

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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