Detailed information for compound 1449917

Basic information

Technical information
  • TDR Targets ID: 1449917
  • Name: 2-(2-methylpiperidin-1-yl)-N-(4-phenoxyphenyl )acetamide hydrochloride
  • MW: 360.878 | Formula: C20H25ClN2O2
  • H donors: 1 H acceptors: 1 LogP: 4.77 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1)Oc1ccccc1)CN1CCCCC1C.Cl
  • InChi: 1S/C20H24N2O2.ClH/c1-16-7-5-6-14-22(16)15-20(23)21-17-10-12-19(13-11-17)24-18-8-3-2-4-9-18;/h2-4,8-13,16H,5-7,14-15H2,1H3,(H,21,23);1H
  • InChiKey: RNPCDDMOLAHQAY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(2-methyl-1-piperidyl)-N-(4-phenoxyphenyl)acetamide hydrochloride
  • 2-(2-methyl-1-piperidinyl)-N-(4-phenoxyphenyl)acetamide hydrochloride
  • 2-(2-methylpiperidin-1-yl)-N-(4-phenoxyphenyl)ethanamide hydrochloride
  • SMR000142801
  • MLS000535363

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Animal haem peroxidase family protein 0.0207 0.2283 0.5032
Echinococcus multilocularis peroxisome assembly protein 26 0.0258 0.29 0.2894
Trypanosoma brucei PAB1-binding protein , putative 0.0054 0.0422 0.1177
Brugia malayi hypothetical protein 0.0069 0.0597 0.1302
Brugia malayi beta-tubulin, identical 0.0315 0.3591 0.7923
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0332 0.0903
Onchocerca volvulus 0.0027 0.009 0.0255
Schistosoma mansoni ap endonuclease 0.004 0.0255 0.0292
Echinococcus multilocularis tubulin epsilon chain 0.019 0.2068 0.2061
Entamoeba histolytica tubulin gamma chain 0.019 0.2068 0.5749
Onchocerca volvulus Huntingtin homolog 0.0136 0.1417 0.5021
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0107 0.1068 0.2957
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0219 0.0211
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0306 0.3641
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0216 0.0579
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0278 0.0319
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0258 0.29 0.8071
Schistosoma mansoni notch 0.0027 0.009 0.0097
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0038 0.023 0.0222
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0278 0.0598
Brugia malayi GCC2 and GCC3 family protein 0.0027 0.009 0.0181
Loa Loa (eye worm) hypothetical protein 0.0041 0.0264 0.0567
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0315 0.3591 0.3586
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Onchocerca volvulus 0.0059 0.0477 0.1647
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0408 0.1115
Echinococcus multilocularis tubulin alpha chain 0.0258 0.29 0.2894
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0126 0.1298 0.1291
Leishmania major zeta tubulin, putative 0.0082 0.0764 0.2111
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0186
Loa Loa (eye worm) tubulin gamma chain 0.019 0.2068 0.4555
Onchocerca volvulus 0.0069 0.0597 0.2076
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0249 0.0672
Entamoeba histolytica hypothetical protein 0.0078 0.0715 0.1974
Leishmania major hypothetical protein, conserved 0.0054 0.0422 0.1157
Loa Loa (eye worm) pax transcription factor protein 2 0.025 0.2802 0.6179
Schistosoma mansoni single-minded 0.0051 0.0378 0.0438
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0306 0.0833
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0255 0.0691
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0278 0.0271
Echinococcus multilocularis tubulin alpha chain 0.0258 0.29 0.2894
Loa Loa (eye worm) hypothetical protein 0.0058 0.0464 0.1009
Loa Loa (eye worm) hypothetical protein 0.0212 0.2335 0.5146
Leishmania major beta tubulin 0.0315 0.3591 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0258 0.29 0.2894
Echinococcus granulosus alpha tubulin 0.0258 0.29 0.3415
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0071 0.0175
Echinococcus granulosus protein jagged 1 0.0027 0.009 0.0097
Brugia malayi Cadherin domain containing protein 0.0027 0.009 0.0181
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0038 0.023 0.0491
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0053 0.0408 0.1115
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0141 0.0274
Trypanosoma brucei beta tubulin 0.0315 0.3591 1
Trypanosoma cruzi zeta tubulin, putative 0.0082 0.0764 0.2111
Trypanosoma cruzi tubulin gamma chain 0.019 0.2068 0.5749
Trypanosoma brucei tubulin gamma chain 0.019 0.2068 0.5758
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0053 0.0408 0.1115
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0332 0.0924
Onchocerca volvulus 0.0031 0.0141 0.044
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0255 0.0691
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Echinococcus granulosus delta-like protein 1 0.0027 0.009 0.0097
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.29 0.3415
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0389 0.1062
Loa Loa (eye worm) hypothetical protein 0.0246 0.2749 0.6062
Loa Loa (eye worm) MH2 domain-containing protein 0.0027 0.0089 0.0179
Echinococcus multilocularis tubulin alpha chain 0.0258 0.29 0.2894
Schistosoma mansoni microtubule-associated protein tau 0.0717 0.8475 1
Schistosoma mansoni smad 0.0027 0.0089 0.0096
Echinococcus granulosus lamin 0.0059 0.0477 0.0554
Loa Loa (eye worm) hypothetical protein 0.0033 0.0169 0.0355
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0051 0.0389 0.5031
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0087 0.0122
Onchocerca volvulus Dual oxidase homolog 0.0207 0.2283 0.8136
Giardia lamblia Beta tubulin 0.0315 0.3591 1
Brugia malayi MAP kinase sur-1 0.0053 0.0408 0.0884
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0332 0.0924
Brugia malayi Cytochrome P450 family protein 0.0034 0.0179 0.0378
Onchocerca volvulus Peroxidase homolog 0.0207 0.2283 0.8136
Trypanosoma cruzi zeta tubulin, putative 0.0082 0.0764 0.2111
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0212 0.2335 0.6495
Toxoplasma gondii beta tubulin 0.0315 0.3591 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0315 0.3591 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0255 0.0292
Echinococcus granulosus tubulin beta 1 chain 0.0315 0.3591 0.4231
Schistosoma mansoni tubulin subunit epsilon 0.019 0.2068 0.2432
Brugia malayi Pre-SET motif family protein 0.0216 0.2391 0.5271
Schistosoma mansoni hypothetical protein 0.0364 0.4188 0.4937
Loa Loa (eye worm) BEN-1 protein 0.0315 0.3591 0.7923
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0278 0.0319
Echinococcus granulosus peroxidasin 0.0207 0.2283 0.2687
Echinococcus multilocularis fibropellin Ia 0.0027 0.009 0.0082
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Entamoeba histolytica hypothetical protein 0.0027 0.0087 0.0221
Schistosoma mansoni tubulin subunit beta 0.0315 0.3591 0.4231
Loa Loa (eye worm) tubulin beta chain 0.0315 0.3591 0.7923
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0027 0.0087 0.1049
Loa Loa (eye worm) blistered cuticle protein 3 0.0207 0.2283 0.5032
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0027 0.0089 0.0096
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0255 0.0691
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0176 0.19 0.4183
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0332 0.0903
Schistosoma mansoni aryl hydrocarbon receptor 0.0051 0.0378 0.0438
Trichomonas vaginalis tubulin alpha chain, putative 0.0107 0.1068 0.2957
Mycobacterium ulcerans DNA gyrase subunit B 0.0042 0.0269 0.345
Echinococcus multilocularis neuropeptide s receptor 0.0482 0.5621 0.5618
Giardia lamblia DNA topoisomerase II 0.0121 0.123 0.3411
Mycobacterium ulcerans endonuclease IV 0.008 0.0732 0.957
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0092 0.0876 0.308
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0255 0.0711
Brugia malayi PAS domain containing protein 0.0051 0.0378 0.0819
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Brugia malayi bZIP transcription factor family protein 0.0087 0.0824 0.1805
Trichomonas vaginalis tubulin alpha chain, putative 0.0107 0.1068 0.2957
Schistosoma mansoni smad1 5 8 and 0.0027 0.0089 0.0096
Onchocerca volvulus Huntingtin homolog 0.0136 0.1417 0.5021
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0132
Echinococcus multilocularis protein dispatched 1 0.0104 0.1023 0.1016
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0278 0.0319
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Plasmodium falciparum DNA topoisomerase 2 0.0126 0.1298 0.3535
Trypanosoma brucei zeta tubulin, putative 0.0082 0.0764 0.2129
Echinococcus granulosus Niemann Pick C1 protein 0.0212 0.2335 0.2748
Echinococcus multilocularis isocitrate dehydrogenase 0.0051 0.0389 0.0381
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0255 0.3271
Echinococcus granulosus L aminoadipate semialdehyde 0.0094 0.0913 0.1068
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0408 0.1115
Echinococcus granulosus tubulin alpha 3 chain 0.0258 0.29 0.3415
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0278 0.0598
Schistosoma mansoni tubulin subunit beta 0.0315 0.3591 0.4231
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0278 0.0319
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0278 0.0319
Loa Loa (eye worm) hypothetical protein 0.0151 0.1596 0.3513
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.2718 0.5993
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0278 0.0598
Echinococcus granulosus intermediate filament protein 0.0059 0.0477 0.0554
Plasmodium vivax SET domain protein, putative 0.0031 0.0141 0.0274
Mycobacterium tuberculosis Cell division protein FtsZ 0.0082 0.0764 1
Schistosoma mansoni notch 0.0027 0.009 0.0097
Echinococcus granulosus tubulin alpha chain 0.0258 0.29 0.3415
Brugia malayi hypothetical protein 0.0207 0.2283 0.5032
Leishmania major beta tubulin 0.0315 0.3591 1
Echinococcus multilocularis tubulin gamma 1 chain 0.019 0.2068 0.2061
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0389 0.045
Echinococcus granulosus protein jagged 2 0.0027 0.009 0.0097
Echinococcus multilocularis fat cadherin tumor suppressor 0.0027 0.009 0.0082
Leishmania major beta tubulin 0.0315 0.3591 1
Schistosoma mansoni tubulin subunit alpha 0.0258 0.29 0.3415
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.007 0.0174
Schistosoma mansoni tubulin subunit gamma 0.019 0.2068 0.2432
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0278 0.0598
Schistosoma mansoni tubulin subunit delta 0.0082 0.0764 0.0893
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0732 0.1601
Brugia malayi isocitrate dehydrogenase 0.0051 0.0389 0.0842
Plasmodium falciparum tubulin epsilon chain, putative 0.019 0.2068 0.5705
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Loa Loa (eye worm) hypothetical protein 0.017 0.1824 0.4017
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Loa Loa (eye worm) hypothetical protein 0.0085 0.0795 0.1741
Toxoplasma gondii alpha tubulin TUBA1 0.0258 0.29 0.8051
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0278 0.0598
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.29 0.8071
Echinococcus granulosus mitogen activated protein kinase 3 0.0053 0.0408 0.0472
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0071 0.0175
Echinococcus multilocularis jun protein 0.0087 0.0824 0.0817
Loa Loa (eye worm) hypothetical protein 0.0111 0.1116 0.245
Trypanosoma brucei epsilon tubulin 0.019 0.2068 0.5758
Schistosoma mansoni peroxidasin 0.0207 0.2283 0.2687
Trypanosoma brucei alpha tubulin 0.0258 0.29 0.8075
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Loa Loa (eye worm) notch protein 0.0027 0.009 0.0181
Schistosoma mansoni peroxidasin 0.0207 0.2283 0.2687
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0408 0.1115
Loa Loa (eye worm) tubulin beta-1 chain 0.0315 0.3591 0.7923
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0255 0.0547
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.009 0.0097
Mycobacterium ulcerans epimerase 0.0021 0.0019 0.0143
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0764 0.2111
Mycobacterium ulcerans DNA gyrase subunit A 0.0023 0.0044 0.0477
Toxoplasma gondii exonuclease III APE 0.004 0.0255 0.0596
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0332 0.0903
Plasmodium vivax tubulin epsilon chain, putative 0.019 0.2068 0.5705
Brugia malayi steroid hormone receptor 0.0042 0.0278 0.0598
Echinococcus granulosus smad 0.0027 0.0089 0.0096
Leishmania major beta tubulin 0.0315 0.3591 1
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0126 0.1298 0.2852
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0422 0.1157
Entamoeba histolytica hypothetical protein 0.0078 0.0715 0.1974
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0193
Leishmania major beta tubulin 0.0315 0.3591 1
Trypanosoma brucei beta tubulin 0.0315 0.3591 1
Loa Loa (eye worm) tubulin alpha-3 chain 0.0151 0.1596 0.3513
Brugia malayi follicle stimulating hormone receptor 0.0243 0.2718 0.5993
Brugia malayi Peroxidasin 0.0207 0.2283 0.5032
Loa Loa (eye worm) alpha-tubulin 0.0258 0.29 0.6395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0216 0.0579
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Brugia malayi Tubulin beta-1 chain 0.0315 0.3591 0.7923
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Giardia lamblia Alpha-tubulin 0.0258 0.29 0.8071
Echinococcus granulosus Protein patched homolog 1 0.0091 0.0867 0.1015
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0278 0.0271
Mycobacterium tuberculosis DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0023 0.0044 0.0477
Schistosoma mansoni hypothetical protein 0.0088 0.0828 0.0968
Loa Loa (eye worm) hypothetical protein 0.0051 0.0389 0.0842
Schistosoma mansoni intermediate filament proteins 0.0059 0.0477 0.0554
Loa Loa (eye worm) animal heme peroxidase 0.0207 0.2283 0.5032
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0278 0.0319
Leishmania major beta tubulin 0.0315 0.3591 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0114 0.1143 0.3184
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.29 0.2894
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0278 0.0598
Echinococcus granulosus Tubulin beta 2C chain 0.0315 0.3591 0.4231
Schistosoma mansoni hypothetical protein 0.0088 0.0828 0.0968
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0278 0.0319
Chlamydia trachomatis DNA gyrase subunit B 0.0068 0.0597 0.8032
Brugia malayi Tubulin alpha chain 0.0258 0.29 0.6395
Trichomonas vaginalis tubulin epsilon chain, putative 0.0258 0.29 0.8071
Loa Loa (eye worm) hypothetical protein 0.033 0.3769 0.8317
Onchocerca volvulus 0.0027 0.009 0.0255
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Onchocerca volvulus 0.0037 0.0219 0.0719
Trypanosoma cruzi epsilon tubulin, putative 0.019 0.2068 0.5749
Trichomonas vaginalis conserved hypothetical protein 0.0091 0.0867 0.2399
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0273 0.0313
Trichomonas vaginalis set domain proteins, putative 0.0246 0.2754 0.7666
Giardia lamblia Gamma tubulin 0.019 0.2068 0.5749
Onchocerca volvulus Peroxidasin homolog 0.0207 0.2283 0.8136
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0833
Onchocerca volvulus Putative cubilin 0.0027 0.009 0.0255
Echinococcus granulosus tumor protein p63 0.0351 0.4029 0.475
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0732 0.1939
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0068 0.0132
Schistosoma mansoni Smad4 0.0027 0.0089 0.0096
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0087 0.0243
Echinococcus multilocularis peroxidasin 0.0207 0.2283 0.2277
Echinococcus multilocularis microtubule associated protein 2 0.0717 0.8475 0.8474
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0141 0.0157
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0278 0.0319
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0278 0.0598
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0531 0.6912
Loa Loa (eye worm) hypothetical protein 0.0028 0.0108 0.0222
Echinococcus granulosus tubulin alpha chain 0.0258 0.29 0.3415
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0179 0.0477
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0332 0.0903
Schistosoma mansoni hypothetical protein 0.0071 0.0626 0.073
Trypanosoma brucei epsilon tubulin 0.019 0.2068 0.5758
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0216 0.0579
Loa Loa (eye worm) cytochrome P450 family protein 0.0055 0.0429 0.0931
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0306 0.0833
Schistosoma mansoni alpha tubulin 0.0258 0.29 0.3415
Plasmodium falciparum alpha tubulin 2 0.0258 0.29 0.8051
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0833
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0278 0.0271
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0019 0.0024
Schistosoma mansoni lamin 0.0059 0.0477 0.0554
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0078 0.0715 0.0708
Loa Loa (eye worm) tubulin beta chain 0.0082 0.0764 0.1673
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0278 0.0319
Brugia malayi Tubulin alpha-2 chain 0.0258 0.29 0.6395
Trichomonas vaginalis tubulin alpha chain, putative 0.0107 0.1068 0.2957
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0008 0.0022
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0051 0.0389 0.0381
Onchocerca volvulus 0.0027 0.009 0.0255
Brugia malayi Smad1 0.0027 0.0089 0.0179
Brugia malayi Tubulin beta chain 0.0107 0.1068 0.2343
Echinococcus multilocularis tubulin subunit TubB 0.0258 0.29 0.2894
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0071 0.0175
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0132
Echinococcus granulosus tubulin subunit beta 0.0315 0.3591 0.4231
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.01 0.0257
Trichomonas vaginalis tubulin epsilon chain, putative 0.0315 0.3591 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0027 0.0087 0.0629
Plasmodium falciparum DNA gyrase subunit B 0.0042 0.0269 0.0634
Plasmodium vivax DNA topoisomerase II, putative 0.0126 0.1298 0.3535
Schistosoma mansoni laminin gamma-3 chain 0.0027 0.009 0.0097
Echinococcus multilocularis musashi 0.0059 0.0477 0.047
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.29 0.8071
Schistosoma mansoni tubulin subunit beta 0.0315 0.3591 0.4231
Trichomonas vaginalis tubulin epsilon chain, putative 0.0315 0.3591 1
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.009 0.0181
Echinococcus multilocularis expressed conserved protein 0.0199 0.2179 0.2173
Echinococcus granulosus lamin dm0 0.0059 0.0477 0.0554
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.29 0.8071
Loa Loa (eye worm) isocitrate dehydrogenase 0.0051 0.0389 0.0842
Schistosoma mansoni notch 0.0027 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Brugia malayi Tubulin alpha-2 chain 0.0258 0.29 0.6395
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0255 0.0547
Brugia malayi Tubulin beta chain 0.0082 0.0764 0.1673
Trichomonas vaginalis tubulin gamma chain, putative 0.019 0.2068 0.5749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.007 0.0174
Leishmania major beta tubulin 0.0315 0.3591 1
Trypanosoma cruzi DNA topoisomerase II, putative 0.0114 0.1143 0.3169
Chlamydia trachomatis endonuclease IV 0.008 0.0732 1
Brugia malayi MH2 domain containing protein 0.0027 0.0089 0.0179
Schistosoma mansoni tubulin subunit beta 0.0082 0.0764 0.0893
Leishmania major beta tubulin 0.0315 0.3591 1
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0126 0.1298 0.2852
Onchocerca volvulus 0.0207 0.2283 0.8136
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0389 0.0971
Brugia malayi hypothetical protein 0.0078 0.0715 0.1564
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Trichomonas vaginalis tubulin alpha chain, putative 0.019 0.2068 0.5749
Schistosoma mansoni cell polarity protein 0.0027 0.009 0.0097
Leishmania major beta tubulin 0.0315 0.3591 1
Trypanosoma brucei alpha tubulin 0.0258 0.29 0.8075
Brugia malayi Cell division protein ftsZ 0.0082 0.0764 0.1673
Trichomonas vaginalis tubulin beta chain, putative 0.0107 0.1068 0.2957
Plasmodium vivax tubulin alpha chain, putative 0.0258 0.29 0.8051
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0278 0.0598
Schistosoma mansoni hypothetical protein 0.0054 0.0417 0.0483
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0127 0.0141
Brugia malayi Animal haem peroxidase family protein 0.0207 0.2283 0.5032
Brugia malayi cytoplasmic intermediate filament protein 0.0031 0.0146 0.0306
Trichomonas vaginalis tubulin, putative 0.0107 0.1068 0.2957
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0025 0.0068 0.007
Loa Loa (eye worm) tubulin beta-2A chain 0.0315 0.3591 0.7923
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0278 0.0319
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0215 0.2375 0.2795
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0278 0.0598
Loa Loa (eye worm) tubulin beta-4 chain 0.0315 0.3591 0.7923
Echinococcus granulosus fibropellin Ia 0.0027 0.009 0.0097
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0278 0.0319
Trypanosoma brucei epsilon tubulin 0.019 0.2068 0.5758
Echinococcus multilocularis neurogenic locus protein delta 0.0027 0.009 0.0082
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0024 0.006 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0145 0.0382
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0042 0.0269 0.3122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0255 0.0691
Echinococcus granulosus Niemann Pick C1 protein 0.0302 0.3438 0.4051
Loa Loa (eye worm) Notch2 0.0027 0.009 0.0181
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0278 0.0319
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0133 0.0348
Brugia malayi Nuclear hormone receptor-like 1 0.0025 0.0068 0.0132
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0278 0.0598
Entamoeba histolytica tubulin family protein 0.0315 0.3591 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0025 0.0068 0.006
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0278 0.0271
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0278 0.0932
Loa Loa (eye worm) hypothetical protein 0.0136 0.1417 0.3115
Brugia malayi hypoxia-induced factor 1 0.0156 0.1665 0.3664
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0531 0.0618
Echinococcus granulosus neurogenic locus notch protein 4 0.0027 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0051 0.0389 0.0971
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0087 0.0122
Echinococcus granulosus neurogenic locus protein delta 0.0027 0.009 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Echinococcus multilocularis slit 2 protein 0.0027 0.009 0.0082
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0091 0.0867 0.1901
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0027 0.009 0.0255
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0216 0.0581
Brugia malayi Cadherin domain containing protein 0.0027 0.009 0.0181
Trypanosoma brucei alpha tubulin, putative 0.0107 0.1068 0.2973
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0306 0.0299
Echinococcus multilocularis Smad4 0.0027 0.0089 0.0081
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0176 0.19 0.4183
Schistosoma mansoni voltage-gated potassium channel 0.0042 0.0273 0.0313
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0255 0.0691
Schistosoma mansoni tubulin subunit beta 0.0315 0.3591 0.4231
Entamoeba histolytica DNA topoisomerase II, putative 0.0126 0.1298 0.36
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0078 0.0715 0.0835
Onchocerca volvulus 0.0027 0.009 0.0255
Echinococcus granulosus tubulin epsilon chain 0.019 0.2068 0.2432
Onchocerca volvulus 0.0042 0.0278 0.0932
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.019 0.2068 0.5705
Plasmodium falciparum alpha tubulin 1 0.0258 0.29 0.8051
Loa Loa (eye worm) Smad1 0.0027 0.0089 0.0179
Leishmania major epsilon tubulin, putative 0.019 0.2068 0.5749
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0053 0.0408 0.1025
Echinococcus granulosus Tubulin beta 2C chain 0.0315 0.3591 0.4231
Trypanosoma brucei beta tubulin 0.0315 0.3591 1
Leishmania major DNA topoisomerase ii 0.0114 0.1143 0.3169
Trypanosoma brucei alpha tubulin 0.0258 0.29 0.8075
Leishmania major beta tubulin 0.0315 0.3591 1
Schistosoma mansoni septate junction protein 0.0027 0.009 0.0097
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Trypanosoma brucei protein kinase, putative 0.0053 0.0408 0.1135
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0278 0.0598
Trichomonas vaginalis CMGC family protein kinase 0.0053 0.0408 0.1115
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0141 0.0133
Entamoeba histolytica tubulin alpha-1 chain 0.0258 0.29 0.8071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0278 0.0598
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0141 0.0157
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0255 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0216 0.0579
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0027 0.0087 0.1049
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0278 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Echinococcus granulosus tubulin alpha 1C chain 0.0258 0.29 0.3415
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0278 0.0271
Onchocerca volvulus 0.0051 0.0389 0.1329
Entamoeba histolytica hypothetical protein 0.0078 0.0715 0.1974
Echinococcus multilocularis neural cadherin 0.0027 0.009 0.0082
Leishmania major beta tubulin 0.0315 0.3591 1
Echinococcus granulosus geminin 0.0364 0.4188 0.4937
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0141 0.0157
Trypanosoma cruzi DNA topoisomerase II, putative 0.0114 0.1143 0.3169
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0389 0.1062
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0051 0.0389 0.0449
Trichomonas vaginalis tubulin, putative 0.0315 0.3591 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.01 0.0257
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0278 0.0319
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0833
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0278 0.0598
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.29 0.3415
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0031 0.0146 0.0306
Loa Loa (eye worm) hypoxia-induced factor 1 0.0156 0.1665 0.3664
Loa Loa (eye worm) hypothetical protein 0.0085 0.0793 0.1737
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0099 0.097 0.2686
Echinococcus multilocularis mothers against decapentaplegic 5 0.0027 0.0089 0.0081
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0028 0.0108 0.0119
Echinococcus multilocularis hypothetical protein 0.0258 0.29 0.2894
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0053 0.0408 0.0884
Plasmodium falciparum tubulin delta chain, putative 0.0082 0.0764 0.2031
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0255 0.2934
Onchocerca volvulus Slit protein homolog 0.0027 0.009 0.0255
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0038 0.023 0.0262
Plasmodium vivax tubulin gamma chain, putative 0.019 0.2068 0.5705
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Brugia malayi ecdysteroid receptor 0.0042 0.0278 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Loa Loa (eye worm) BEN-1 protein 0.0315 0.3591 0.7923
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0278 0.0598
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Trypanosoma brucei zeta tubulin 0.0082 0.0764 0.2129
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0278 0.0319
Echinococcus granulosus peroxisome assembly protein 26 0.0258 0.29 0.3415
Schistosoma mansoni slit 0.0027 0.009 0.0097
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0114 0.1143 0.3184
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0179 0.0378
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.29 0.8071
Schistosoma mansoni smad1 5 8 and 0.0027 0.0089 0.0096
Loa Loa (eye worm) hypothetical protein 0.0136 0.1417 0.3115
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0172 0.1851 0.4076
Echinococcus multilocularis protein patched 0.0091 0.0867 0.086
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0186 0.0401
Brugia malayi Niemann-Pick C1 protein precursor 0.0212 0.2335 0.5146
Brugia malayi MH1 domain containing protein 0.0027 0.0089 0.0179
Echinococcus granulosus tubulin alpha chain 0.0258 0.29 0.3415
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.29 0.3415
Onchocerca volvulus 0.005 0.0373 0.1273
Loa Loa (eye worm) hypothetical protein 0.0021 0.0019 0.0024
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0045 0.0306 0.3944
Schistosoma mansoni hypothetical protein 0.0364 0.4188 0.4937
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0278 0.0598
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.29 0.2894
Echinococcus multilocularis tubulin alpha chain 0.0258 0.29 0.2894
Trypanosoma cruzi epsilon tubulin, putative 0.019 0.2068 0.5749
Brugia malayi Cytochrome P450 family protein 0.0055 0.0429 0.0931
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Trichomonas vaginalis tubulin gamma chain, putative 0.0315 0.3591 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0278 0.0598
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0059 0.0477 0.1038
Trypanosoma cruzi tubulin delta chain 0.0082 0.0764 0.2111
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0496 0.1079
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0071 0.0175
Trichomonas vaginalis tubulin, putative 0.0082 0.0764 0.2111
Echinococcus multilocularis tubulin alpha 3 chain 0.0258 0.29 0.2894
Echinococcus granulosus beta tubulin 0.0315 0.3591 0.4231
Loa Loa (eye worm) hypothetical protein 0.0054 0.0422 0.0917
Giardia lamblia High cysteine protein 0.0027 0.009 0.0229
Loa Loa (eye worm) hypothetical protein 0.0059 0.0477 0.1038
Schistosoma mansoni notch 0.0027 0.009 0.0097
Echinococcus multilocularis mitogen activated protein kinase 0.0053 0.0408 0.04
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.009 0.0181
Giardia lamblia Beta tubulin 0.0315 0.3591 1
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0332 0.0716
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0278 0.0271
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0408 0.1115
Brugia malayi Inositol-1 0.0045 0.0306 0.066
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0042 0.0269 0.0634
Echinococcus granulosus tubulin alpha 0.019 0.2068 0.2432
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Echinococcus granulosus Smad4 0.0027 0.0089 0.0096
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0087 0.06
Brugia malayi hypothetical protein 0.0035 0.0189 0.0401
Brugia malayi MH1 domain containing protein 0.0027 0.0089 0.0179
Echinococcus granulosus mothers against decapentaplegic 5 0.0027 0.0089 0.0096
Loa Loa (eye worm) beta-tubulin 0.0315 0.3591 0.7923
Mycobacterium leprae cell division protein FtsZ 0.0082 0.0764 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0278 0.0271
Brugia malayi MH2 domain containing protein 0.0027 0.0089 0.0179
Brugia malayi hypothetical protein 0.017 0.1824 0.4017
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0019 0.0143
Schistosoma mansoni smad1 5 8 and 0.0027 0.0089 0.0096
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0389 0.0381
Trichomonas vaginalis tubulin gamma chain, putative 0.019 0.2068 0.5749
Loa Loa (eye worm) hypothetical protein 0.0056 0.0442 0.096
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Echinococcus multilocularis Niemann Pick C1 protein 0.0212 0.2335 0.2329
Loa Loa (eye worm) intermediate filament protein 0.0059 0.0477 0.1038
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Echinococcus granulosus expressed conserved protein 0.0199 0.2179 0.2564
Schistosoma mansoni survival motor neuron protein 0.005 0.0373 0.0431
Echinococcus multilocularis lamin 0.0059 0.0477 0.047
Onchocerca volvulus 0.0172 0.1851 0.6583
Giardia lamblia Kinase, CMGC MAPK 0.0053 0.0408 0.1115
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0332 0.0903
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0051 0.0389 0.1062
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0051 0.0389 0.0971
Schistosoma mansoni ap endonuclease 0.004 0.0255 0.0292
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0027 0.0087 0.1049
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Brugia malayi intermediate filament protein 0.0059 0.0477 0.1038
Loa Loa (eye worm) hypothetical protein 0.0258 0.29 0.6395
Giardia lamblia Delta tubulin 0.0082 0.0764 0.2111
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Brugia malayi Calcium binding EGF domain containing protein 0.0027 0.009 0.0181
Schistosoma mansoni inositol monophosphatase 0.0045 0.0306 0.0352
Loa Loa (eye worm) animal heme peroxidase 0.0207 0.2283 0.5032
Schistosoma mansoni DNA topoisomerase II 0.0126 0.1298 0.1523
Echinococcus granulosus Tubulin beta 2C chain 0.0315 0.3591 0.4231
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0027 0.0089 0.0081
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.004 0.025 0.3193
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0053 0.0408 0.1135
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0038 0.023 0.0491
Loa Loa (eye worm) hypothetical protein 0.008 0.0732 0.1601
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0496 0.1079
Brugia malayi hypothetical protein 0.0136 0.1417 0.3115
Leishmania major beta tubulin 0.0315 0.3591 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0141 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0103 0.0266
Echinococcus multilocularis beta tubulin 0.0315 0.3591 0.3586
Loa Loa (eye worm) transcription factor SMAD2 0.0392 0.453 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0051 0.0389 0.1082
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Schistosoma mansoni hypothetical protein 0.0088 0.0828 0.0968
Schistosoma mansoni transcription factor LCR-F1 0.0078 0.0715 0.0835
Trichomonas vaginalis DNA topoisomerase II, putative 0.0126 0.1298 0.36
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0255 0.0691
Trypanosoma brucei alpha tubulin 0.0258 0.29 0.8075
Echinococcus multilocularis lamin dm0 0.0059 0.0477 0.047
Echinococcus multilocularis smad 0.0027 0.0089 0.0081
Trichomonas vaginalis tubulin beta chain, putative 0.0315 0.3591 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0027 0.0089 0.0096
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0027 0.009 0.0097
Schistosoma mansoni alpha tubulin 0.0258 0.29 0.3415
Entamoeba histolytica hypothetical protein 0.0078 0.0715 0.1974
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0732 0.9564
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0332 0.0903
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0278 0.0319
Echinococcus multilocularis neuropeptide receptor A26 0.0482 0.5621 0.5618
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0531 0.6912
Onchocerca volvulus 0.025 0.2802 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0051 0.0389 0.1082
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Schistosoma mansoni patched 1 0.0091 0.0867 0.1015
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0087 0.06
Echinococcus granulosus neuropeptide receptor A26 0.0482 0.5621 0.663
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0092 0.0876 0.308
Echinococcus granulosus tubulin beta 4A class IVa 0.0315 0.3591 0.4231
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0219 0.0466
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0531 0.0523
Brugia malayi Probable DNA topoisomerase II 0.0126 0.1298 0.2852
Echinococcus multilocularis tubulin beta 1 chain 0.0315 0.3591 0.3586
Echinococcus granulosus tubulin alpha chain 0.0258 0.29 0.3415
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Loa Loa (eye worm) CYP4Cod1 0.0034 0.0179 0.0378
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0732 0.957
Echinococcus granulosus microtubule associated protein 2 0.0717 0.8475 1
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Schistosoma mansoni lamin 0.0059 0.0477 0.0554
Echinococcus granulosus Tubulin beta 2C chain 0.0315 0.3591 0.4231
Schistosoma mansoni notch 0.0027 0.009 0.0097
Echinococcus multilocularis protein jagged 1 0.0027 0.009 0.0082
Echinococcus granulosus neurogenic locus notch protein 0.0027 0.009 0.0097
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0306 0.0352
Trypanosoma brucei tubulin delta chain 0.0082 0.0764 0.2129
Echinococcus granulosus single minded 2 0.0041 0.0262 0.03
Onchocerca volvulus Neurogenic locus notch homolog 0.0027 0.009 0.0255
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0087 0.0824 0.0964
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0389 0.0381
Loa Loa (eye worm) TOPoisomerase family member 0.0126 0.1298 0.2852
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0103 0.0266
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0051 0.0389 0.0449
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0278 0.0598
Schistosoma mansoni hypothetical protein 0.0078 0.0715 0.0835
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0141 0.0157
Brugia malayi hypothetical protein 0.0246 0.2749 0.6062
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0053 0.0408 0.1115
Brugia malayi notch-like transmembrane receptor 0.0027 0.009 0.0181
Echinococcus multilocularis sterol regulatory element binding protein 0.0091 0.0867 0.086
Loa Loa (eye worm) hypothetical protein 0.006 0.0496 0.1079
Brugia malayi CHE-14 protein 0.0091 0.0867 0.1901
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0186
Onchocerca volvulus 0.0027 0.009 0.0255
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0216 0.0602
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0278 0.0598
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0151 0.1596 0.4434
Schistosoma mansoni hypothetical protein 0.005 0.0373 0.0431
Brugia malayi Animal haem peroxidase family protein 0.0207 0.2283 0.5032
Leishmania major delta tubulin, putative 0.0082 0.0764 0.2111
Trypanosoma brucei DNA topoisomerase ii 0.0099 0.097 0.2702
Loa Loa (eye worm) tubulin alpha-2 chain 0.0258 0.29 0.6395
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0306 0.0833
Loa Loa (eye worm) alpha-tubulin 0.0258 0.29 0.6395
Trypanosoma brucei beta tubulin 0.019 0.2068 0.5758
Echinococcus multilocularis geminin 0.0364 0.4188 0.4184
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0531 0.6912
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0278 0.0598
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0531 0.1373
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0255 0.0691
Echinococcus multilocularis beta tubulin 0.0315 0.3591 0.3586
Echinococcus multilocularis tubulin delta chain 0.0082 0.0764 0.0757
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0028 0.0108 0.01
Trichomonas vaginalis tubulin epsilon chain, putative 0.0082 0.0764 0.2111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0103 0.0266
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0278 0.0598
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0025 0.0068 0.007
Brugia malayi MH2 domain containing protein 0.0392 0.453 1
Leishmania major beta tubulin 0.0315 0.3591 1
Giardia lamblia GTOR 0.0047 0.0332 0.0903
Echinococcus multilocularis L aminoadipate semialdehyde 0.0094 0.0913 0.0905
Brugia malayi tubulin alpha chain - mouse 0.0258 0.29 0.6395
Onchocerca volvulus 0.0207 0.2283 0.8136
Toxoplasma gondii beta-tubulin, putative 0.0315 0.3591 1
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0008 0.0022
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0141 0.0133
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0278 0.0932
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0132
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Onchocerca volvulus 0.0246 0.2754 0.9828
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0278 0.0271
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0126 0.1298 0.1523
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0193
Trichomonas vaginalis tubulin gamma chain, putative 0.0082 0.0764 0.2111
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0053 0.0408 0.1115
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0278 0.0598
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.009 0.0082
Echinococcus granulosus slit 2 protein 0.0027 0.009 0.0097
Loa Loa (eye worm) tubulin alpha 2 0.0068 0.0596 0.1301
Trichomonas vaginalis tubulin, putative 0.0107 0.1068 0.2957
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Brugia malayi hypothetical protein 0.0025 0.0068 0.0132
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0199 0.0534
Brugia malayi Blistered cuticle protein 3 0.0207 0.2283 0.5032
Brugia malayi nuclear receptor RXR 0.0025 0.0068 0.0132
Trypanosoma brucei unspecified product 0.002 0.0008 0.0022
Schistosoma mansoni hypothetical protein 0.0088 0.0828 0.0968
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0278 0.0319
Brugia malayi Intermediate filament tail domain containing protein 0.0059 0.0477 0.1038
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0255 0.0248
Loa Loa (eye worm) inositol-1 0.0045 0.0306 0.066
Leishmania major beta tubulin 0.0315 0.3591 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0332 0.0716
Trichomonas vaginalis tubulin epsilon chain, putative 0.0258 0.29 0.8071
Giardia lamblia Beta tubulin 0.0315 0.3591 1
Loa Loa (eye worm) tubulin alpha 2 0.0176 0.19 0.4183
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0278 0.0319
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Loa Loa (eye worm) tubulin alpha chain 0.0258 0.29 0.6395
Mycobacterium leprae conserved hypothetical protein 0.0027 0.0087 0.0919
Onchocerca volvulus 0.0207 0.2283 0.8136
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0255 0.3271
Toxoplasma gondii LsmAD domain-containing protein 0.0054 0.0422 0.1067
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0025 0.0068 0.007
Brugia malayi hypothetical protein 0.0172 0.1851 0.4076
Echinococcus granulosus protein jagged 2 0.0027 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Echinococcus granulosus protein jagged 1 0.0027 0.009 0.0097
Schistosoma mansoni serine/threonine protein kinase 0.0053 0.0408 0.0472
Onchocerca volvulus 0.0094 0.0913 0.3211
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0278 0.0598
Brugia malayi nuclear receptor NHR-88 0.0042 0.0278 0.0598
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0332 0.0903
Schistosoma mansoni tubulin subunit beta 0.0315 0.3591 0.4231
Mycobacterium ulcerans cell division protein FtsZ 0.0082 0.0764 1
Schistosoma mansoni alpha tubulin 0.0258 0.29 0.3415
Schistosoma mansoni jun-related protein 0.0071 0.0626 0.073
Echinococcus multilocularis tubulin alpha 0.019 0.2068 0.2061
Echinococcus granulosus neural cadherin 0.0027 0.009 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0216 0.0579
Chlamydia trachomatis DNA gyrase subunit B 0.0042 0.0269 0.3269
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Echinococcus multilocularis tubulin alpha chain 0.0258 0.29 0.2894
Loa Loa (eye worm) animal heme peroxidase 0.0207 0.2283 0.5032
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0087 0.0122
Plasmodium vivax tubulin beta chain, putative 0.0315 0.3591 1
Brugia malayi Isocitrate dehydrogenase 0.0051 0.0389 0.0842
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Brugia malayi Animal haem peroxidase family protein 0.0207 0.2283 0.5032
Loa Loa (eye worm) hypothetical protein 0.0031 0.0141 0.0295
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0332 0.0903
Echinococcus granulosus beta tubulin 0.0315 0.3591 0.4231
Echinococcus granulosus tubulin gamma 1 chain 0.019 0.2068 0.2432
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0087 0.0221
Echinococcus multilocularis Tubulin beta 2C chain 0.0315 0.3591 0.3586
Echinococcus multilocularis neurogenic locus notch protein 4 0.0027 0.009 0.0082
Leishmania major mitochondrial DNA topoisomerase II 0.0099 0.097 0.2686
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0099 0.097 0.2686
Entamoeba histolytica tubulin alpha chain, putative 0.0258 0.29 0.8071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.007 0.0174
Onchocerca volvulus Chorion peroxidase homolog 0.0207 0.2283 0.8136
Echinococcus granulosus tubulin subunit TubB 0.0258 0.29 0.3415
Schistosoma mansoni hypothetical protein 0.0024 0.006 0.0061
Trypanosoma cruzi cytochrome P450, putative 0.0034 0.0179 0.0477
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0087 0.0122
Plasmodium vivax DNA gyrase subunit B, putative 0.0042 0.0269 0.0634
Schistosoma mansoni tubulin subunit alpha 0.0258 0.29 0.3415
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0219 0.2788
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0278 0.0319
Echinococcus multilocularis neurogenic locus protein delta 0.0027 0.009 0.0082
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0255 0.2934
Echinococcus granulosus sterol regulatory element binding protein 0.0091 0.0867 0.1015
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0082 0.0764 0.2031
Schistosoma mansoni notch 0.0027 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0207 0.2283 0.5032
Loa Loa (eye worm) MH2 domain-containing protein 0.0392 0.453 1
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.025 0.3094
Echinococcus granulosus tubulin delta chain 0.0082 0.0764 0.0893
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0019 0.0143
Loa Loa (eye worm) hypothetical protein 0.0056 0.0442 0.096
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Echinococcus granulosus mitogen activated protein kinase 0.0053 0.0408 0.0472
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0087 0.0824 0.0817
Echinococcus multilocularis Tubulin beta 2C chain 0.0315 0.3591 0.3586
Echinococcus multilocularis Tubulin beta 2C chain 0.0315 0.3591 0.3586
Echinococcus multilocularis Tubulin beta 2C chain 0.0315 0.3591 0.3586
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0008 0.0022
Echinococcus multilocularis tubulin subunit beta 0.0315 0.3591 0.3586
Trypanosoma brucei cytochrome P450, putative 0.0034 0.0179 0.0498
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0531 0.1459
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0176 0.19 0.528
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0264 0.0567
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.2391 0.5271
Schistosoma mansoni coup transcription factor 0.0042 0.0278 0.0319
Brugia malayi Delta serrate ligand family protein 0.0027 0.009 0.0181
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0422 0.1067
Brugia malayi hypothetical protein 0.0054 0.0422 0.0917
Onchocerca volvulus Peroxidasin homolog 0.0207 0.2283 0.8136
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0531 0.6912
Echinococcus granulosus neuropeptide s receptor 0.0482 0.5621 0.663
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0094 0.0913 0.1068
Loa Loa (eye worm) cytochrome P450 family protein 0.0034 0.0179 0.0378
Schistosoma mansoni tubulin subunit alpha 0.0258 0.29 0.3415
Trypanosoma brucei beta tubulin 0.0315 0.3591 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Brugia malayi nuclear hormone receptor 0.0042 0.0278 0.0598
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Toxoplasma gondii EGF family domain-containing protein 0.0027 0.009 0.0129
Toxoplasma gondii alpha-tubulin I, putative 0.0258 0.29 0.8051
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.29 0.8071
Onchocerca volvulus 0.0107 0.1068 0.3768
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0053 0.0408 0.1115
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0332 0.0324
Schistosoma mansoni tubulin subunit alpha 0.0082 0.0764 0.0893
Toxoplasma gondii isocitrate dehydrogenase 0.0051 0.0389 0.0971
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0255 0.0596
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0278 0.0319
Echinococcus granulosus tubulin alpha 1C chain 0.0258 0.29 0.3415
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0082 0.0764 0.2111
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Loa Loa (eye worm) MH1 domain-containing protein 0.0027 0.0089 0.0179
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0332 0.0382
Brugia malayi Cytochrome P450 family protein 0.0034 0.0179 0.0378
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0042 0.0269 0.3122
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0278 0.0319
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0082 0.0764 1
Loa Loa (eye worm) hypothetical protein 0.0091 0.0867 0.1901
Echinococcus multilocularis survival motor neuron protein 1 0.0246 0.2749 0.2743
Treponema pallidum cell division protein FtsZ 0.0082 0.0764 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0306 0.0853
Brugia malayi hypothetical protein 0.0126 0.1301 0.2859
Leishmania major beta tubulin 0.0315 0.3591 1
Loa Loa (eye worm) hypothetical protein 0.0085 0.0793 0.1737
Echinococcus multilocularis tubulin alpha 1C chain 0.0258 0.29 0.2894
Echinococcus multilocularis protein jagged 2 0.0027 0.009 0.0082
Brugia malayi Animal haem peroxidase family protein 0.0207 0.2283 0.5032
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0531 0.0618
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0764 0.2111
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.29 0.8071
Brugia malayi Tubulin alpha chain 0.0082 0.0764 0.1673
Giardia lamblia Epsilon tubulin 0.0082 0.0764 0.2111
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0732 0.1939
Echinococcus granulosus Tubulin beta 2C chain 0.0315 0.3591 0.4231
Giardia lamblia Alpha-tubulin 0.0258 0.29 0.8071
Mycobacterium ulcerans hypothetical protein 0.0021 0.0019 0.0143
Schistosoma mansoni hypothetical protein 0.0041 0.0264 0.0303
Echinococcus multilocularis tubulin alpha 3 chain 0.0258 0.29 0.2894
Schistosoma mansoni tubulin subunit beta 0.0315 0.3591 0.4231
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0496 0.1079
Brugia malayi tubulin alpha-2 chain 0.0258 0.29 0.6395
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0278 0.0271
Echinococcus granulosus jun protein 0.0087 0.0824 0.0964
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0598
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0033 0.0091
Schistosoma mansoni inositol monophosphatase 0.0045 0.0306 0.0352
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0092 0.0876 0.308
Plasmodium falciparum tubulin beta chain 0.0315 0.3591 1
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Leishmania major beta tubulin 0.0315 0.3591 1
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0306 0.0833
Brugia malayi EGF-like domain containing protein 0.0027 0.009 0.0181
Plasmodium vivax tubulin alpha chain, putative 0.0258 0.29 0.8051
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.29 0.2894
Brugia malayi Tubulin gamma chain 0.019 0.2068 0.4555
Echinococcus multilocularis protein jagged 1 0.0027 0.009 0.0082
Trypanosoma cruzi PAB1-binding protein , putative 0.0054 0.0422 0.1157
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0332 0.0903
Toxoplasma gondii beta-1 tubulin, putative 0.0315 0.3591 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0531 0.0618
Toxoplasma gondii DNA topoisomerase 2, putative 0.0126 0.1298 0.3535
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0036 0.0199 0.0534
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Echinococcus granulosus survival motor neuron protein 1 0.0246 0.2749 0.3238
Loa Loa (eye worm) tubulin alpha chain 0.0258 0.29 0.6395
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0278 0.0598
Plasmodium falciparum tubulin gamma chain 0.019 0.2068 0.5705
Loa Loa (eye worm) animal heme peroxidase 0.0207 0.2283 0.5032
Brugia malayi hypothetical protein 0.0025 0.0068 0.0132
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0042 0.0269 0.345
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0027 0.009 0.0181
Loa Loa (eye worm) tubulin alpha 2 0.0176 0.19 0.4183
Leishmania major alpha tubulin 0.0258 0.29 0.8071
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0373 0.0808
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0024 0.006 0.0061
Brugia malayi Pre-SET motif family protein 0.0031 0.0141 0.0295
Schistosoma mansoni hypothetical protein 0.0027 0.009 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Echinococcus multilocularis notch 0.0027 0.009 0.0082
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0216 0.0581
Plasmodium vivax ataxin-2 like protein, putative 0.0054 0.0422 0.1067
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0082 0.0764 0.2031
Brugia malayi alpha-tubulin 0.0258 0.29 0.6395
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0034 0.0179 0.2259
Echinococcus multilocularis tumor protein p63 0.0351 0.4029 0.4025
Echinococcus multilocularis Tubulin beta 2C chain 0.0315 0.3591 0.3586
Echinococcus multilocularis Niemann Pick C1 protein 0.0302 0.3438 0.3433
Onchocerca volvulus 0.0059 0.0477 0.1647
Leishmania major cytochrome p450-like protein 0.0034 0.0179 0.0477
Leishmania major beta tubulin 0.0315 0.3591 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0181
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0332 0.0382
Echinococcus granulosus notch 0.0027 0.009 0.0097
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0008 0.0022
Loa Loa (eye worm) hypothetical protein 0.0094 0.0913 0.2
Leishmania major beta tubulin 0.0315 0.3591 1
Trypanosoma cruzi tubulin delta chain 0.0082 0.0764 0.2111
Echinococcus multilocularis neurogenic locus notch protein 0.0027 0.009 0.0082
Echinococcus multilocularis mitogen activated protein kinase 3 0.0053 0.0408 0.04
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0306 0.0739
Echinococcus granulosus tubulin alpha chain 0.0258 0.29 0.3415
Entamoeba histolytica tubulin family protein 0.0315 0.3591 1
Plasmodium vivax delta tubulin, putative 0.0082 0.0764 0.2031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0186 0.0498
Plasmodium falciparum ataxin-2 like protein, putative 0.0054 0.0422 0.1067
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0278 0.0932
Echinococcus granulosus tubulin alpha 3 chain 0.0258 0.29 0.3415
Trypanosoma cruzi alpha tubulin, putative 0.0258 0.29 0.8071
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0278 0.0598
Brugia malayi Muscle positioning protein 4 0.0027 0.009 0.0181
Toxoplasma gondii endonuclease IV APN 0.008 0.0732 0.1939
Leishmania major gamma-tubulin 0.019 0.2068 0.5749
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0025 0.0068 0.0132
Onchocerca volvulus Peroxidase homolog 0.0207 0.2283 0.8136
Brugia malayi Pax transcription factor protein 2 0.025 0.2802 0.6179
Trypanosoma cruzi beta tubulin, putative 0.0315 0.3591 1
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0094 0.0913 0.2
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0051 0.0389 0.0381

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 3.9811 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (binding) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 25.1189 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702] ChEMBL. No reference
Potency (functional) 29.0929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6294 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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