Detailed information for compound 154061

Basic information

Technical information
  • TDR Targets ID: 154061
  • Name: 2-[[(2S)-2-aminopropanoyl]amino]acetic acid
  • MW: 146.144 | Formula: C5H10N2O3
  • H donors: 3 H acceptors: 3 LogP: -3.65 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C(=O)NCC(=O)O)N
  • InChi: 1S/C5H10N2O3/c1-3(6)5(10)7-2-4(8)9/h3H,2,6H2,1H3,(H,7,10)(H,8,9)/t3-/m0/s1
  • InChiKey: CXISPYVYMQWFLE-VKHMYHEASA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[[(2S)-2-amino-1-oxopropyl]amino]acetic acid
  • 2-[[(2S)-2-azanylpropanoyl]amino]ethanoic acid
  • 2-[[(2S)-2-azaniumylpropanoyl]amino]acetate
  • 2-[[(2S)-2-ammonio-1-oxopropyl]amino]acetate
  • 2-[[(2S)-2-azaniumylpropanoyl]amino]ethanoate
  • 2-[[(2S)-2-ammoniopropanoyl]amino]acetate
  • alanylglycine
  • 2-[[(2S)-2-aminopropanoyl]amino]ethanoic acid
  • ZINC01888744

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens solute carrier family 15 (oligopeptide transporter), member 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans second version of peptide transport protein more similar to S. cerevisiae PTR2 Get druggable targets OG5_126717 All targets in OG5_126717
Brugia malayi POT family protein Get druggable targets OG5_126717 All targets in OG5_126717
Candida albicans second version of peptide transport protein more similar to S. cerevisiae PTR2 Get druggable targets OG5_126717 All targets in OG5_126717
Loa Loa (eye worm) POT family protein Get druggable targets OG5_126717 All targets in OG5_126717
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0306 0.2649 0.2638
Echinococcus granulosus lamin 0.0027 0.0152 0.0152
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0063 0.0063
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0063 0.0053
Brugia malayi Protein kinase domain containing protein 0.0023 0.012 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0063 0.0048
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0017 0.0064 0.012
Echinococcus granulosus sterol O acyltransferase 1 0.032 0.2776 0.2776
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0193 0.0177
Leishmania major cathepsin L-like protease 0.1114 0.9865 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0195 0.0195
Brugia malayi bZIP transcription factor family protein 0.0078 0.061 0.0596
Echinococcus multilocularis Protein son of sevenless 0.0012 0.0016 0.0016
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0107 0.0872 0.2226
Schistosoma mansoni hypothetical protein 0.0023 0.012 0.011
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.0872 0.0862
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1129 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0188 0.0189
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0086 0.0685 0.0685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1129 1 1
Giardia lamblia Cathepsin L precursor 0.0107 0.0872 0.2148
Brugia malayi Cytochrome P450 family protein 0.0025 0.0138 0.0122
Loa Loa (eye worm) hypothetical protein 0.0107 0.0872 0.0872
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0017 0.0064 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0193 0.046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0243 0.2084 0.2111
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0063 0.0048
Entamoeba histolytica hypothetical protein 0.0036 0.0232 0.0562
Brugia malayi nuclear hormone receptor 0.0017 0.0063 0.0048
Onchocerca volvulus 0.0017 0.0063 0.0112
Schistosoma mansoni cpg binding protein 0.0032 0.0195 0.0184
Brugia malayi latrophilin 2 splice variant baaae 0.004 0.0271 0.0256
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.0872 0.2226
Loa Loa (eye worm) hypothetical protein 0.0289 0.2497 0.2497
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0078 0.061 0.061
Schistosoma mansoni cathepsin F (C01 family) 0.0306 0.2649 0.2641
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0063 0.0063
Plasmodium falciparum serine repeat antigen 7 0.0107 0.0872 0.1851
Schistosoma mansoni cathepsin F (C01 family) 0.0442 0.3861 0.3855
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0017 0.0064 0.012
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.0872 0.2226
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.0872 0.0857
Plasmodium falciparum serine repeat antigen 1 0.0107 0.0872 0.1851
Echinococcus granulosus intermediate filament protein 0.0027 0.0152 0.0152
Brugia malayi cathepsin F-like cysteine proteinase 0.0107 0.0872 0.0857
Brugia malayi Cytochrome P450 family protein 0.0053 0.0387 0.0371
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0063 0.0053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0257 0.0242
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0063 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.0872 0.2226
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0063 0.0048
Schistosoma mansoni hypothetical protein 0.0308 0.2667 0.2659
Loa Loa (eye worm) hypothetical protein 0.0328 0.2847 0.2847
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0221 0.0946
Leishmania major cathepsin L-like protease 0.1114 0.9865 1
Onchocerca volvulus 0.0486 0.4258 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0442 0.3861 1
Brugia malayi beta-lactamase 0.0036 0.0231 0.0216
Leishmania major glycerol uptake protein, putative 0.0031 0.0193 0.0154
Echinococcus multilocularis Ankyrin 0.0023 0.0122 0.0122
Loa Loa (eye worm) beta-lactamase 0.0036 0.0231 0.0231
Echinococcus multilocularis rap guanine nucleotide exchange factor 1 0.0012 0.0016 0.0016
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0276 0.0279
Brugia malayi N-terminal motif family protein 0.0328 0.2847 0.2836
Schistosoma mansoni lamin 0.0027 0.0152 0.0141
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0016 0.0057 0.0057
Trichomonas vaginalis transmembrane protein nessy, putative 0.0031 0.0193 0.046
Entamoeba histolytica hypothetical protein 0.0031 0.0193 0.046
Schistosoma mansoni hypothetical protein 0.0063 0.048 0.0469
Onchocerca volvulus Cathepsin L homolog 0.0107 0.0872 0.2017
Loa Loa (eye worm) hypothetical protein 0.0107 0.0872 0.0872
Plasmodium falciparum serine repeat antigen 3 0.0107 0.0872 0.1851
Echinococcus granulosus tar DNA binding protein 0.0063 0.0473 0.0473
Giardia lamblia Cysteine protease 0.0107 0.0872 0.2148
Brugia malayi MBOAT family protein 0.0031 0.0193 0.0177
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Brugia malayi fibroinase precursor 0.0107 0.0872 0.0857
Loa Loa (eye worm) hypothetical protein 0.0239 0.2048 0.2048
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0016 0.0016
Brugia malayi ecdysteroid receptor 0.0017 0.0063 0.0048
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0442 0.3861 0.3861
Leishmania major cathepsin L-like protease 0.0442 0.3861 0.3889
Schistosoma mansoni cytochrome P450 0.0017 0.0064 0.0053
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0063 0.0053
Leishmania major cathepsin L-like protease 0.0442 0.3861 0.3889
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.004 0.0271 0.026
Entamoeba histolytica cysteine protease, putative 0.0107 0.0872 0.2226
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0064 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0063 0.0048
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Brugia malayi Cathepsin L-like precursor 0.0442 0.3861 0.3852
Loa Loa (eye worm) POT family protein 0.0049 0.0353 0.0353
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.0872 0.2226
Loa Loa (eye worm) hypothetical protein 0.0107 0.0872 0.0872
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0031 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0016 0.0005
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0021 0.0099 0.0306
Echinococcus granulosus netrin receptor unc 5 0.0023 0.012 0.012
Brugia malayi RNA binding protein 0.0063 0.0473 0.0458
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0107 0.0872 0.2148
Loa Loa (eye worm) hypothetical protein 0.1129 1 1
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0276 1
Onchocerca volvulus 0.0442 0.3861 0.9064
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0017 0.0064 0.012
Echinococcus multilocularis cathepsin L 0.0107 0.0872 0.0872
Leishmania major DNA polymerase kappa, putative 0.0021 0.0099 0.0059
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0017 0.0064 0.012
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0978 0.8653 0.865
Echinococcus granulosus segment polarity protein dishevelled 0.0016 0.0057 0.0057
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0193 0.0193
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0257 0.0242
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.0068
Plasmodium falciparum serine repeat antigen 8 0.0107 0.0872 0.1851
Brugia malayi Hhat protein 0.0031 0.0193 0.0177
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0231 0.056
Schistosoma mansoni hypothetical protein 0.0308 0.2667 0.2659
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0016 0.0016
Entamoeba histolytica cysteine protease, putative 0.0107 0.0872 0.2226
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1129 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0021 0.0099 0.0099
Giardia lamblia Cathepsin B precursor 0.0423 0.3695 1
Giardia lamblia Cathepsin L-like protease 0.0107 0.0872 0.2148
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0017 0.0064 0.012
Schistosoma mansoni thyroid hormone receptor 0.0103 0.0835 0.0826
Echinococcus granulosus cathepsin l1 0.0306 0.2649 0.2649
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0442 0.3861 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0017 0.0064 0.012
Echinococcus multilocularis jun protein 0.0078 0.061 0.061
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.0068
Loa Loa (eye worm) hypothetical protein 0.0107 0.0872 0.0872
Plasmodium falciparum cysteine proteinase falcipain 1 0.0243 0.2084 0.5155
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0872 0.2226
Trypanosoma cruzi cysteine protease, putative 0.0243 0.2084 0.2071
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.2084 0.5377
Brugia malayi cathepsin L precursor 0.0107 0.0872 0.0857
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0017 0.0064 0.0063
Schistosoma mansoni coup transcription factor 0.0017 0.0063 0.0053
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0138 0.0138
Echinococcus multilocularis cathepsin b 0.1129 1 1
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0257 0.9116
Toxoplasma gondii hypothetical protein 0.0031 0.0193 0.0472
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0057 0.0057
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0023 0.0122 0.0112
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0243 0.2084 0.2075
Giardia lamblia Cysteine protease 0.0107 0.0872 0.2148
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0107 0.0872 0.1851
Treponema pallidum alginate O-acetylation protein (algI) 0.0031 0.0193 0.5
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.2084 0.5377
Trypanosoma cruzi GUP1, putative 0.0031 0.0193 0.0177
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0063 0.0063
Schistosoma mansoni cpg binding protein 0.0033 0.0211 0.02
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0063 0.0048
Trypanosoma brucei cysteine peptidase C (CPC) 0.0423 0.3695 0.3745
Giardia lamblia Cathepsin B precursor 0.0107 0.0872 0.2148
Loa Loa (eye worm) hypothetical protein 0.0107 0.0872 0.0872
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.051 0.05
Entamoeba histolytica cysteine protease, putative 0.0107 0.0872 0.2226
Echinococcus multilocularis lamin 0.0027 0.0152 0.0152
Loa Loa (eye worm) DIX domain-containing protein 0.0016 0.0057 0.0057
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0221 0.9397
Echinococcus multilocularis dnaJ subfamily B 0.0449 0.3926 0.3926
Schistosoma mansoni dishevelled 0.0016 0.0057 0.0047
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0193 0.0177
Plasmodium falciparum serine repeat antigen 2 0.0107 0.0872 0.1851
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Trypanosoma cruzi cysteine peptidase, putative 0.1114 0.9865 0.9864
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0031 0.0193 0.0193
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0231 0.7892
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0107 0.0872 0.0872
Echinococcus granulosus cathepsin L 0.0243 0.2084 0.2084
Echinococcus granulosus cathepsin L 0.0107 0.0872 0.0872
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0059 0.0059
Loa Loa (eye worm) ctsf protein 0.0442 0.3861 0.3861
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0107 0.0872 0.1851
Brugia malayi POT family protein 0.0049 0.0353 0.0338
Echinococcus granulosus nuclear factor of activated T cells 5 0.0119 0.0976 0.0976
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0999
Plasmodium vivax serine-repeat antigen (SERA) 0.0107 0.0872 0.1851
Brugia malayi MBOAT family protein 0.0031 0.0193 0.0177
Schistosoma mansoni cathepsin C 0.0107 0.0872 0.0862
Plasmodium vivax unspecified product 0.0243 0.2084 0.5155
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0341 0.0325
Loa Loa (eye worm) fibroinase 0.0442 0.3861 0.3861
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0423 0.3695 0.372
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0017 0.0064 0.012
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0107 0.0872 0.2226
Entamoeba histolytica cysteine protease, putative 0.0442 0.3861 1
Plasmodium vivax serine-repeat antigen (SERA) 0.0107 0.0872 0.1851
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0193 0.0182
Leishmania major glycerol uptake protein, putative 0.0031 0.0193 0.0154
Loa Loa (eye worm) hypothetical protein 0.0031 0.0188 0.0188
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0014 0.0041 0.0041
Trypanosoma cruzi cysteine proteinase, putative 0.0243 0.2084 0.2071
Trypanosoma brucei unspecified product 0.0034 0.0218 0.022
Entamoeba histolytica deoxycytidyl transferase, putative 0.0014 0.0041 0.0065
Echinococcus granulosus death domain containing protein 0.0023 0.012 0.012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0063 0.0063
Brugia malayi Cytochrome P450 family protein 0.0025 0.0138 0.0122
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0057
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0473 0.0473
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Onchocerca volvulus 0.0032 0.0195 0.0421
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0063 0.0048
Toxoplasma gondii cathepsin CPL 0.0442 0.3861 1
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0063 0.0053
Toxoplasma gondii cathepsin CPC2 0.0107 0.0872 0.2236
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0193 0.0193
Mycobacterium ulcerans hypothetical protein 0.0036 0.0231 0.7892
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.0872 0.0862
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.0068
Brugia malayi Cathepsin L-like cysteine proteinase 0.0306 0.2649 0.2638
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.201 0.201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.0872 0.2226
Schistosoma mansoni hypothetical protein 0.0019 0.0079 0.0068
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0193 0.046
Schistosoma mansoni ras GTP exchange factor 0.0012 0.0016 0.0005
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0463
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0017 0.0064 0.012
Trichomonas vaginalis esterase, putative 0.0036 0.0231 0.056
Echinococcus multilocularis dna polymerase eta 0.0014 0.0041 0.0041
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0017 0.0064 0.012
Plasmodium vivax vivapain-2 0.0442 0.3861 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Leishmania major cathepsin L-like protease 0.0442 0.3861 0.3889
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0107 0.0872 0.2148
Schistosoma mansoni intermediate filament proteins 0.0027 0.0152 0.0141
Echinococcus multilocularis cysteine protease 0.0442 0.3861 0.3861
Echinococcus granulosus dna polymerase kappa 0.0041 0.0276 0.0276
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0063 0.0063
Toxoplasma gondii ABC1 family protein 0.0036 0.0231 0.0572
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1129 1 1
Mycobacterium leprae Probable lipase LipE 0.0036 0.0231 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0063 0.0053
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0016 0.0005
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0014 0.0041 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0193 0.046
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0023 0.012 0.012
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.2084 0.5377
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0239 0.2048 0.2036
Trypanosoma brucei cytochrome P450, putative 0.0025 0.0138 0.0139
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0017 0.0064 0.012
Echinococcus granulosus son of sevenless 1 0.0012 0.0016 0.0016
Brugia malayi hypothetical protein 0.0235 0.201 0.1998
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0023 0.012 0.012
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Giardia lamblia Cathepsin B precursor 0.0107 0.0872 0.2148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0193 0.046
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0243 0.2084 0.2075
Brugia malayi steroid hormone receptor 0.0017 0.0063 0.0048
Giardia lamblia Hypothetical protein 0.0107 0.0872 0.2148
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0063 0.0048
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0057 0.0057
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0031 0.0193 0.0182
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0063 0.0048
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0463
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0057
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0107 0.0872 0.0862
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0107 0.0872 0.2226
Leishmania major cytochrome p450-like protein 0.0025 0.0138 0.0099
Entamoeba histolytica hypothetical protein 0.0036 0.0232 0.0562
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0031 0.0193 0.0193
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0014 0.0041 0.003
Schistosoma mansoni thyroid hormone receptor 0.0103 0.0835 0.0826
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0138 0.0122
Entamoeba histolytica cysteine protease, putative 0.0107 0.0872 0.2226
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0152 0.0152
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0463
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.0872 0.2226
Loa Loa (eye worm) hypothetical protein 0.004 0.0271 0.0271
Loa Loa (eye worm) cytochrome P450 family protein 0.0025 0.0138 0.0138
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0447 0.1132
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0025 0.0138 0.3491
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.0872 0.2226
Echinococcus multilocularis netrin receptor unc 5 0.0023 0.012 0.012
Leishmania major hypothetical protein, conserved 0.0031 0.0193 0.0154
Trypanosoma brucei DNA polymerase IV, putative 0.0034 0.0218 0.022
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0063 0.0063
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0031 0.0193 0.0193
Loa Loa (eye worm) hypothetical protein 0.0014 0.0041 0.0041
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0231 0.0999
Entamoeba histolytica hypothetical protein 0.0036 0.0232 0.0562
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0231 0.0231
Giardia lamblia Cathepsin L precursor 0.0107 0.0872 0.2148
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0473 0.0473
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0063 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0059 0.0059
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0231 0.0231
Schistosoma mansoni lamin 0.0027 0.0152 0.0141
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0442 0.3861 0.3861
Brugia malayi Calcitonin receptor-like protein seb-1 0.0059 0.0437 0.0422
Toxoplasma gondii preprocathepsin c precursor, putative 0.0107 0.0872 0.2236
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0063 0.0063
Brugia malayi Cathepsin L-like precursor 0.0442 0.3861 0.3852
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0107 0.0872 0.1851
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0041 0.0041
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0257 0.022
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0107 0.0872 0.1851
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0231 0.0999
Brugia malayi Papain family cysteine protease containing protein 0.0442 0.3861 0.3852
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0017 0.0064 0.012
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0063 0.0048
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0024
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0031 0.0193 0.0472
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0257 0.5
Loa Loa (eye worm) hypothetical protein 0.0136 0.1125 0.1125
Schistosoma mansoni DNA polymerase eta 0.0014 0.0041 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0063 0.0063
Brugia malayi Cytochrome P450 family protein 0.0017 0.0064 0.0048
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.0872 0.0862
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0231 0.7892
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0387 0.0387
Brugia malayi cytochrome P450 0.0017 0.0064 0.0048
Schistosoma mansoni regulator of G protein signaling 0.0016 0.0057 0.0047
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0107 0.0872 0.0872
Schistosoma mansoni cathepsin B (C01 family) 0.0107 0.0872 0.0862
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0107 0.0872 0.2148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0063 0.0063
Loa Loa (eye worm) hhat protein 0.0031 0.0193 0.0193
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0193 0.0193
Echinococcus granulosus Ankyrin 0.0023 0.0122 0.0122
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0079 0.0063
Loa Loa (eye worm) hypothetical protein 0.0486 0.4258 0.4258
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0231 0.0999
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0028 0.0028
Entamoeba histolytica hypothetical protein 0.0036 0.0232 0.0562
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0063 0.0112
Plasmodium vivax vivapain-1 0.0243 0.2084 0.5155
Echinococcus granulosus ras GTP exchange factor 0.0012 0.0016 0.0016
Echinococcus multilocularis thyroid hormone receptor alpha 0.0103 0.0835 0.0835
Echinococcus granulosus jun protein 0.0078 0.061 0.061
Onchocerca volvulus 0.0027 0.0152 0.0321
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0193 0.0193
Schistosoma mansoni ankyrin 23/unc44 0.0023 0.012 0.011
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0473 0.0458
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0232 0.0221
Loa Loa (eye worm) hypothetical protein 0.0012 0.0016 0.0016
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0463
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Giardia lamblia Cathepsin L precursor 0.0107 0.0872 0.2148
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0107 0.0872 0.2226
Brugia malayi hypothetical protein 0.0036 0.0232 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0442 0.3861 0.3861
Plasmodium falciparum serine repeat antigen 9 0.0107 0.0872 0.1851
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0107 0.0872 0.2226
Schistosoma mansoni sterol O-acyltransferase 1 0.032 0.2776 0.2769
Echinococcus granulosus lamin dm0 0.0027 0.0152 0.0152
Echinococcus granulosus GPCR family 2 0.0019 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0063 0.0063
Echinococcus multilocularis cathepsin L cysteine protease 0.0442 0.3861 0.3861
Schistosoma mansoni inositol monophosphatase 0.0039 0.0257 0.0247
Echinococcus multilocularis Protein lozenge 0.0061 0.0458 0.0458
Trypanosoma cruzi cytochrome P450, putative 0.0025 0.0138 0.0122
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0031 0.0193 0.0193
Onchocerca volvulus 0.0061 0.0461 0.1048
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0078 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0152 0.0136
Loa Loa (eye worm) hypothetical protein 0.0442 0.3861 0.3861
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0306 0.2649 0.2649
Trichomonas vaginalis porcupine, putative 0.0031 0.0193 0.046
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Echinococcus multilocularis segment polarity protein dishevelled 0.0016 0.0057 0.0057
Brugia malayi CXXC zinc finger family protein 0.0032 0.0195 0.0179
Schistosoma mansoni survival motor neuron protein 0.0048 0.0341 0.033
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0257 0.0257
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0193 0.0182
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Brugia malayi beta-lactamase family protein 0.0036 0.0231 0.0216
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0219 0.1872 0.1872
Schistosoma mansoni cathepsin S (C01 family) 0.0107 0.0872 0.0862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0243 0.2084 0.2111
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0243 0.2084 0.2075
Giardia lamblia Cathepsin B precursor 0.0107 0.0872 0.2148
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Echinococcus granulosus o acyltransferase membrane bound domain 0.0031 0.0193 0.0193
Schistosoma mansoni dishevelled 0.0016 0.0057 0.0047
Brugia malayi cathepsin L-like precursor 0.0306 0.2649 0.2638
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0107 0.0872 0.2226
Echinococcus multilocularis geminin 0.0308 0.2667 0.2667
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0063 0.0063
Mycobacterium ulcerans lipase LipD 0.0036 0.0231 0.7892
Giardia lamblia Cathepsin L precursor 0.0107 0.0872 0.2148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0306 0.2649 0.2649
Loa Loa (eye worm) hypothetical protein 0.0235 0.201 0.201
Schistosoma mansoni netrin receptor unc5 0.0023 0.012 0.011
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0257 0.0628
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0107 0.0872 0.1851
Trypanosoma cruzi cruzipain precursor, putative 0.0136 0.1125 0.1111
Plasmodium vivax vivapain-2 0.0442 0.3861 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0231 0.056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Entamoeba histolytica vacuolar protein sorting 26 0.0031 0.0193 0.046
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0031 0.0193 0.0193
Mycobacterium ulcerans DNA polymerase IV 0.0041 0.0276 1
Echinococcus multilocularis ras GTP exchange factor 0.0012 0.0016 0.0016
Onchocerca volvulus Netrin receptor homolog 0.0023 0.012 0.0247
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Onchocerca volvulus 0.0442 0.3861 0.9064
Loa Loa (eye worm) CYP4Cod1 0.0025 0.0138 0.0138
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0079 0.0079
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0079
Echinococcus multilocularis son of sevenless 1 0.0012 0.0016 0.0016
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0999
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0063 0.0063
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Schistosoma mansoni dep domain containing protein 0.0016 0.0057 0.0047
Echinococcus granulosus geminin 0.0308 0.2667 0.2667
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.2649 0.6848
Giardia lamblia Cathepsin L-like protease 0.0107 0.0872 0.2148
Echinococcus multilocularis musashi 0.0027 0.0152 0.0152
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0257 0.064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0107 0.0872 0.2226
Echinococcus granulosus dna polymerase eta 0.0014 0.0041 0.0041
Echinococcus multilocularis cpg binding protein 0.0033 0.0211 0.0211
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0276 0.0261
Entamoeba histolytica cysteine proteinase 1, putative 0.0243 0.2084 0.5377
Loa Loa (eye worm) RasGEF domain-containing protein 0.0012 0.0016 0.0016
Onchocerca volvulus 0.0036 0.0231 0.0508
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0031 0.0193 0.0193
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0473 0.0463
Echinococcus multilocularis rap guanine nucleotide exchange factor 6 0.0012 0.0016 0.0016
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0086 0.0685 0.0685
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0031 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0243 0.2084 0.5377
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Leishmania major hypothetical protein, conserved 0.0036 0.0231 0.0194
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0023 0.012 0.012
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0199 0.169 0.169
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0276 0.0261
Loa Loa (eye worm) cathepsin B 0.0423 0.3695 0.3695
Brugia malayi Cathepsin L-like precursor 0.0442 0.3861 0.3852
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0017 0.0064 0.0048
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0193
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.2084 0.5377
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0031 0.0193 0.0193
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0107 0.0872 0.1851
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0193 0.046
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0063 0.0048
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0442 0.3861 1
Onchocerca volvulus 0.0027 0.0152 0.0321
Echinococcus granulosus Protein son of sevenless 0.0012 0.0016 0.0016
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.0216
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0442 0.3861 0.3861
Onchocerca volvulus 0.0107 0.0872 0.2017
Brugia malayi Cathepsin L-like precursor 0.0442 0.3861 0.3852
Loa Loa (eye worm) RNA binding protein 0.0063 0.0473 0.0473
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0107 0.0872 0.2148
Entamoeba histolytica cysteine proteinase, putative 0.0442 0.3861 1
Schistosoma mansoni hypothetical protein 0.0036 0.0232 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0423 0.3695 0.9567
Loa Loa (eye worm) hypothetical protein 0.0107 0.0872 0.0872
Echinococcus multilocularis lamin dm0 0.0027 0.0152 0.0152
Brugia malayi regulator of G-protein signaling egl-10 0.0016 0.0057 0.0042
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0107 0.0872 0.0857
Brugia malayi hypothetical protein 0.0061 0.0461 0.0446
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0231 0.0231
Entamoeba histolytica cysteine proteinase 2 0.0243 0.2084 0.5377
Trypanosoma cruzi major cysteine proteinase, putative 0.0779 0.6875 0.687
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0107 0.0872 0.1851
Schistosoma mansoni hypothetical protein 0.0031 0.0193 0.0182
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0017 0.0064 0.012
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.0872 0.0857
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0031 0.0193 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.0442 0.3861 0.3852
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.012 0.0105
Brugia malayi Cathepsin L-like precursor 0.0442 0.3861 0.3852
Loa Loa (eye worm) hypothetical protein 0.0136 0.1125 0.1125
Echinococcus granulosus segment polarity protein dishevelled 0.0016 0.0057 0.0057
Schistosoma mansoni cathepsin F (C01 family) 0.0442 0.3861 0.3855
Brugia malayi Cathepsin L-like precursor 0.0136 0.1125 0.1111
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0107 0.0872 0.1851
Onchocerca volvulus Cathepsin L homolog 0.0442 0.3861 0.9064
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0063 0.0053
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0063 0.0048
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Onchocerca volvulus 0.0442 0.3861 0.9064
Plasmodium falciparum cysteine proteinase falcipain 3 0.0442 0.3861 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0014 0.0041 0.003
Echinococcus granulosus cytochrome P450 2K1 0.0017 0.0064 0.0064
Echinococcus multilocularis cathepsin L 0.0243 0.2084 0.2084
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0017 0.0064 0.012
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0031 0.0193 0.0193
Onchocerca volvulus 0.0031 0.0193 0.0417
Loa Loa (eye worm) hypothetical protein 0.0306 0.2649 0.2649
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0063 0.0053
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0872 0.2226
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Schistosoma mansoni cathepsin s 0.0136 0.1125 0.1115
Entamoeba histolytica cysteine protease, putative 0.0107 0.0872 0.2226
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0014 0.0041 0.0041
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.056
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.0872 0.0862
Loa Loa (eye worm) hypothetical protein 0.0027 0.0152 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Onchocerca volvulus 0.0036 0.0231 0.0508
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0231 0.0999
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0231 0.0221
Loa Loa (eye worm) cytochrome P450 0.0017 0.0064 0.0064
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0031 0.0193 0.0193
Brugia malayi intermediate filament protein 0.0027 0.0152 0.0136
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0107 0.0872 0.0862
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0442 0.3861 0.3861
Loa Loa (eye worm) hypothetical protein 0.0076 0.0591 0.0591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0059 0.0059
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Trypanosoma cruzi GUP1, putative 0.0031 0.0193 0.0177
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Brugia malayi Death domain containing protein 0.0023 0.012 0.0105
Toxoplasma gondii hypothetical protein 0.0016 0.0057 0.012
Brugia malayi polk-prov protein 0.0031 0.0188 0.0172
Giardia lamblia Cathepsin L precursor 0.0107 0.0872 0.2148
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0016 0.0057 0.0047
Plasmodium falciparum serine repeat antigen 5 0.0107 0.0872 0.1851
Brugia malayi Uncoordinated protein 44 0.0023 0.012 0.0105
Trypanosoma cruzi cruzipain precursor, putative 0.1114 0.9865 0.9864
Loa Loa (eye worm) hhat protein 0.0031 0.0193 0.0193
Trypanosoma brucei glycerol uptake protein, putative 0.0031 0.0193 0.0194
Brugia malayi Cathepsin L-like precursor 0.0442 0.3861 0.3852
Echinococcus granulosus cathepsin b 0.1129 1 1
Schistosoma mansoni zinc finger protein 0.0031 0.0193 0.0182
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0193 0.0193
Onchocerca volvulus 0.0048 0.0341 0.0766
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0193 0.0193
Trypanosoma cruzi major cysteine proteinase, putative 0.0107 0.0872 0.0857
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0107 0.0872 0.1851
Onchocerca volvulus 0.0306 0.2649 0.6207
Echinococcus multilocularis cysteine protease 0.0442 0.3861 0.3861
Toxoplasma gondii cathepsin CPC1 0.0107 0.0872 0.2236
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0016 0.0057 0.0042
Leishmania major cathepsin L-like protease 0.1114 0.9865 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0031 0.0188 0.0189
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0276 0.0261
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Loa Loa (eye worm) hypothetical protein 0.032 0.2776 0.2776
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0136 0.1125 0.1125
Trypanosoma cruzi glycerol uptake protein, putative 0.0031 0.0193 0.0177
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0041 0.0025
Plasmodium vivax vivapain-3 0.0243 0.2084 0.5155
Onchocerca volvulus Cathepsin L homolog 0.0442 0.3861 0.9064
Onchocerca volvulus Cathepsin F homolog 0.0442 0.3861 0.9064
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0107 0.0872 0.2226
Echinococcus granulosus cathepsin L cysteine protease 0.0243 0.2084 0.2084
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0231 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0136 0.1125 0.1111
Loa Loa (eye worm) MBOAT family protein 0.0031 0.0193 0.0193
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Schistosoma mansoni hypothetical protein 0.0449 0.3926 0.3919
Giardia lamblia Cysteine protease 0.0107 0.0872 0.2148
Echinococcus granulosus cathepsin b 0.1129 1 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0231 0.0999
Brugia malayi diacylglycerol acyltransferase 0.0031 0.0193 0.0177
Brugia malayi Inositol-1 0.0039 0.0257 0.0242
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Echinococcus multilocularis 0.0017 0.0064 0.0064
Entamoeba histolytica cysteine proteinase, putative 0.0442 0.3861 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0442 0.3861 0.3861
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0119 0.0976 0.0976
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0193
Leishmania major cysteine peptidase A (CPA) 0.0442 0.3861 0.3889
Echinococcus multilocularis segment polarity protein dishevelled 0.0016 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0024
Mycobacterium ulcerans beta-lactamase 0.0036 0.0231 0.7892
Brugia malayi nuclear receptor NHR-88 0.0017 0.0063 0.0048
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0063 0.0048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0041 0.0276 0.0677
Entamoeba histolytica cysteine proteinase, putative 0.0306 0.2649 0.6848
Leishmania major cytochrome p450-like protein 0.0017 0.0064 0.0023
Trypanosoma brucei glycerol uptake protein, putative 0.0031 0.0193 0.0194
Loa Loa (eye worm) hypothetical protein 0.0023 0.0122 0.0122
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0016 0.0057 0.0057
Onchocerca volvulus 0.0442 0.3861 0.9064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0107 0.0872 0.1851
Leishmania major cytochrome p450-like protein 0.0017 0.0064 0.0023
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0107 0.0872 0.2226
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0016 0.0057 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0107 0.0872 0.2226
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.0872 0.2226
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0063 0.0048
Echinococcus granulosus cathepsin l1 0.0442 0.3861 0.3861
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0063 0.0053
Giardia lamblia Hypothetical protein 0.0107 0.0872 0.2148
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0017 0.0064 0.012
Brugia malayi MBOAT family protein 0.0031 0.0193 0.0177
Giardia lamblia Cathepsin B precursor 0.0107 0.0872 0.2148
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0231 0.0216
Echinococcus granulosus cysteine protease 0.0243 0.2084 0.2084
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0231 0.0216
Trypanosoma brucei DNA polymerase eta, putative 0.0014 0.0041 0.004
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0031 0.0193 0.0182
Trypanosoma cruzi cysteine peptidase, putative 0.0243 0.2084 0.2071
Entamoeba histolytica cysteine protease, putative 0.0107 0.0872 0.2226
Echinococcus granulosus dnaJ subfamily B 0.0449 0.3926 0.3926
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0031 0.0193 0.0472
Giardia lamblia Cathepsin B precursor 0.0107 0.0872 0.2148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0057
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0079 0.0079
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.056
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0041 0.0025
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0442 0.3861 1
Plasmodium falciparum serine repeat antigen 6 0.0107 0.0872 0.1851
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0028 0.0028
Trypanosoma cruzi cysteine peptidase, putative 0.1114 0.9865 0.9864
Plasmodium vivax unspecified product 0.0136 0.1125 0.2541
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0232 0.0232
Schistosoma mansoni hypothetical protein 0.0017 0.0064 0.0053
Trypanosoma cruzi DNA polymerase eta, putative 0.0014 0.0041 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0423 0.3695 0.3685
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0107 0.0872 0.0862
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0063 0.0112
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0107 0.0872 0.2226
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0243 0.2084 0.2071
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0423 0.3695 0.3688
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Giardia lamblia Cathepsin L precursor 0.0107 0.0872 0.2148
Loa Loa (eye worm) hypothetical protein 0.0036 0.0231 0.0231
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0231 0.056
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0107 0.0872 0.0872
Brugia malayi Cathepsin L-like precursor 0.0306 0.2649 0.2638
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0063 0.0063
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0063 0.0063
Brugia malayi Papain family cysteine protease containing protein 0.0107 0.0872 0.0857
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0152 0.0152
Echinococcus multilocularis cathepsin b 0.1129 1 1
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0031 0.0193 0.0182
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0107 0.0872 0.0862
Trypanosoma cruzi DNA polymerase kappa, putative 0.0041 0.0276 0.0261
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0473 0.0473
Leishmania major glycerol uptake protein, putative 0.0031 0.0193 0.0154
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0059 0.0437 0.0437
Echinococcus granulosus cpg binding protein 0.0033 0.0211 0.0211
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0079 0.0063
Onchocerca volvulus 0.0036 0.0231 0.0508
Toxoplasma gondii cytochrome p450 superfamily protein 0.0017 0.0064 0.0137
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0021 0.0099 0.0059
Echinococcus granulosus regulator of G protein signaling 7 0.0016 0.0057 0.0057
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0017 0.0064 0.012
Giardia lamblia Cathepsin B precursor 0.0423 0.3695 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0107 0.0872 0.2226
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.201 0.201
Leishmania major cathepsin L-like protease 0.0442 0.3861 0.3889
Giardia lamblia Cysteine protease 0.0107 0.0872 0.2148
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0028
Loa Loa (eye worm) cysteine protease 0.0442 0.3861 0.3861
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0231 0.0999
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0063 0.0112
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0257 0.0628
Echinococcus granulosus cathepsin L cysteine proteinase 0.0442 0.3861 0.3861
Brugia malayi beta-lactamase family protein 0.0036 0.0231 0.0216
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0063 0.0048
Brugia malayi hypothetical protein 0.0486 0.4258 0.4249
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0012 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Loa Loa (eye worm) hypothetical protein 0.0486 0.4258 0.4258
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0257 0.026
Brugia malayi cathepsin L-like cysteine proteinase 0.0107 0.0872 0.0857
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0017 0.0064 0.012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0232 0.0232
Brugia malayi cathepsin F-like cysteine proteinase 0.0136 0.1125 0.1111
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0063 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0328 0.2847 0.6674
Echinococcus multilocularis dna polymerase kappa 0.0041 0.0276 0.0276
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0063 0.0048
Loa Loa (eye worm) hypothetical protein 0.0136 0.1125 0.1125
Brugia malayi ImpB/MucB/SamB family protein 0.0014 0.0041 0.0025
Echinococcus multilocularis sterol O acyltransferase 1 0.032 0.2776 0.2776
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.2084 0.2071
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0107 0.0872 0.1851
Entamoeba histolytica hypothetical protein, conserved 0.0031 0.0193 0.046
Brugia malayi cathepsin Z-like cysteine proteinase 0.0107 0.0872 0.0857
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0231 0.0999
Brugia malayi follicle stimulating hormone receptor 0.0219 0.1872 0.1859
Schistosoma mansoni inositol monophosphatase 0.0039 0.0257 0.0247
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0231 0.0999
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0063 0.0053
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0442 0.3861 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0199 0.169 0.169
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0107 0.0872 0.1851
Onchocerca volvulus 0.0442 0.3861 0.9064
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0012 0.0016 0.0016
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0107 0.0872 0.0862
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0306 0.2649 0.6848
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0063 0.0063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0031 0.0193 0.0193
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0031 0.0193 0.046
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.1947 1
Echinococcus multilocularis GPCR, family 2 0.0019 0.0079 0.0079
Trichomonas vaginalis DNA polymerase eta, putative 0.0041 0.0276 0.0677
Brugia malayi cathepsin Z-like cysteine proteinase 0.0107 0.0872 0.0857
Leishmania major glycerol uptake protein, putative 0.0031 0.0193 0.0154
Plasmodium vivax unspecified product 0.0107 0.0872 0.1851
Leishmania major glycerol uptake protein, putative 0.0031 0.0193 0.0154
Onchocerca volvulus 0.0016 0.0057 0.0098
Loa Loa (eye worm) inositol-1 0.0039 0.0257 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0442 0.3861 1
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0017 0.0064 0.012
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1129 1 1
Echinococcus multilocularis regulator of G protein signaling 7 0.0016 0.0057 0.0057
Loa Loa (eye worm) runx1 0.0061 0.0458 0.0458
Brugia malayi hypothetical protein 0.0016 0.0057 0.0042
Loa Loa (eye worm) hypothetical protein 0.0031 0.0193 0.0193
Schistosoma mansoni hypothetical protein 0.0086 0.0685 0.0675
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0017 0.0064 0.012
Schistosoma mansoni lozenge 0.0061 0.0458 0.0448
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0257 0.0257
Giardia lamblia Encystation-specific protease 0.0107 0.0872 0.2148
Trypanosoma brucei DNA polymerase IV, putative 0.0041 0.0276 0.0279
Trypanosoma cruzi cysteine proteinase, putative 0.0243 0.2084 0.2071
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0063 0.0053
Plasmodium falciparum serine repeat antigen 4 0.0107 0.0872 0.1851
Schistosoma mansoni jun-related protein 0.0063 0.048 0.0469
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0231 0.0106
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0257 0.0628
Schistosoma mansoni hypothetical protein 0.0048 0.0341 0.033
Trypanosoma cruzi cysteine peptidase, putative 0.1114 0.9865 0.9864
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0017 0.0064 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0148 0.0148
Leishmania major cathepsin L-like protease 0.0442 0.3861 0.3889
Onchocerca volvulus 0.0442 0.3861 0.9064
Loa Loa (eye worm) hypothetical protein 0.0017 0.0063 0.0063
Brugia malayi MBOAT family protein 0.0031 0.0193 0.0177
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0257 0.0628
Trypanosoma cruzi cysteine peptidase, putative 0.0136 0.1125 0.1111
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0012 0.0016 0.0005
Loa Loa (eye worm) hypothetical protein 0.0023 0.012 0.012
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0017 0.0064 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0017 0.0064 0.012
Entamoeba histolytica cysteine protease, putative 0.0243 0.2084 0.5377
Brugia malayi DIX domain containing protein 0.0016 0.0057 0.0042
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0063 0.0063
Entamoeba histolytica cysteine proteinase, putative 0.0243 0.2084 0.5377
Schistosoma mansoni cpg binding protein 0.0033 0.0211 0.02
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0107 0.0872 0.1851
Echinococcus granulosus Pleckstrin G protein interacting region 0.0016 0.0057 0.0057
Toxoplasma gondii cathepsin B 0.0423 0.3695 0.9568
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0012 0.0016 0.0016
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1114 0.9865 1
Brugia malayi TAR-binding protein 0.0063 0.0473 0.0458
Brugia malayi hypothetical protein 0.0016 0.0057 0.0042
Giardia lamblia Cathepsin B precursor 0.0423 0.3695 1
Onchocerca volvulus 0.0442 0.3861 0.9064
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0016 0.0057 0.0098
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0231 0.0221
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0031 0.0193 0.0193
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0231 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0276 0.0279
Brugia malayi MBOAT family protein 0.0031 0.0193 0.0177
Schistosoma mansoni z-protein (S1r protein) 0.0016 0.0057 0.0047
Brugia malayi Papain family cysteine protease containing protein 0.0243 0.2084 0.2071

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Activation of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline ChEMBL. 19060912
Activity (binding) < 15 % Activation of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline ChEMBL. 19060912
IC50 (binding) = 2.6 Biological activity of the compound was measured against Angiotensin I converting enzyme ChEMBL. 7629809
IC50 (binding) = 2500 uM Inhibition of rabbit lung ACE preincubated for 5 mins by spectrophotometric assay ChEMBL. 21621881
Inhibition (binding) >= 30 % Inhibition of nitrogen-starved wild type sigma1278b yeast Gap1-mediated amino acid uptake at 5 mM after 60 secs relative to L-citrulline ChEMBL. 19060912
Ki (ADMET) = 2.15 Binding affinity to human PepT2 in SKTP cells ChEMBL. 21741846
Ki (ADMET) = 0.007 mM Binding affinity to human PepT2 in SKTP cells ChEMBL. 21741846
Ki (binding) = 0.14 mM Inhibition constant (Ki) for human intestinal peptide carrier ChEMBL. 14667225
Ki (binding) = 7.3 mM Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells ChEMBL. 15974593
Ki (binding) = 7.3 nM Binding affinity against membrane transport protein PEPT1 in human Caco-2 cells ChEMBL. 15974593
Log 1/IC50 (binding) = 2.6 Biological activity of the compound was measured against Angiotensin I converting enzyme ChEMBL. 7629809

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

5 literature references were collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.