Detailed information for compound 1543553

Basic information

Technical information
  • TDR Targets ID: 1543553
  • Name: N-(4-methylphenyl)-N-[2-oxo-2-(phenylmethylam ino)ethyl]thiadiazole-4-carboxamide
  • MW: 366.437 | Formula: C19H18N4O2S
  • H donors: 1 H acceptors: 4 LogP: 3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(C(=O)c1csnn1)c1ccc(cc1)C)NCc1ccccc1
  • InChi: 1S/C19H18N4O2S/c1-14-7-9-16(10-8-14)23(19(25)17-13-26-22-21-17)12-18(24)20-11-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,24)
  • InChiKey: HXMUNIBCTUFUHZ-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • N-(4-methylphenyl)-N-[2-oxo-2-(phenylmethylamino)ethyl]-4-thiadiazolecarboxamide
  • N-[2-(benzylamino)-2-keto-ethyl]-N-(4-methylphenyl)thiadiazole-4-carboxamide
  • N-(4-methylphenyl)-N-[2-oxo-2-(phenylmethylamino)ethyl]-1,2,3-thiadiazole-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi AMP-binding enzyme family protein 0.0617 0.3756 0.487
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0032 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0177 0.0215
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0039 0.0036
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.0386 0.3311
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0091
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.141 0.2069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni cpg binding protein 0.0057 0.028 0.0537
Leishmania major d-xylulose reductase, putative 0.0041 0.0177 0.1381
Mycobacterium ulcerans short-chain dehydrogenase 0.0045 0.0201 0.027
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0715 0.7457
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0039 0.0199
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0081
Loa Loa (eye worm) hypothetical protein 0.0069 0.0348 0.0511
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0035 0.0048
Mycobacterium ulcerans polyketide synthase Pks13 0.0988 0.6055 1
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.0337 0.0496
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0131 0.0155
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0175 0.0343
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.0552 0.0853
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0035 0.009
Mycobacterium ulcerans thioesterase TesA 0.0551 0.3342 0.549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0174 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.1159 1
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0043 0.0395
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0661 0.4026 0.6627
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0617 0.3756 0.6179
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0177 0.023
Loa Loa (eye worm) fatty acid synthase 0.0652 0.3971 0.5827
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0098
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0152 0.0223
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.145 0.2128
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.002 0.0145
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus granulosus smad 0.0017 0.0027 0.0047
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0131 0.1093
Mycobacterium leprae Polyketide synthase Pks13 0.0988 0.6055 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0062 0.0506
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.0337 0.0495
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.028 0.041
Schistosoma mansoni cpg binding protein 0.0061 0.03 0.0578
Trypanosoma brucei unspecified product 0.0019 0.0043 0.0395
Mycobacterium ulcerans polyketide synthase 0.0661 0.4026 0.6627
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0177 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0039 0.0072
Echinococcus multilocularis cysteine protease 0.0034 0.0131 0.0128
Echinococcus granulosus cathepsin L 0.0017 0.003 0.0054
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0027 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0042 0.0182 0.1731
Mycobacterium ulcerans hypothetical protein 0.0067 0.0337 0.0496
Echinococcus multilocularis lamin 0.0027 0.0089 0.0086
Mycobacterium ulcerans thioesterase 0.0551 0.3342 0.549
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.068 0.1338
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0124 0.1249
Schistosoma mansoni rotamase 0.0033 0.0129 0.0236
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0124 0.1251
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0027 0.0031
Leishmania major oxidoreductase-like protein 0.0041 0.0177 0.1381
Trypanosoma cruzi cysteine protease, putative 0.0017 0.003 0.0102
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0125 0.1029
Schistosoma mansoni methyltransferase-related 0.0199 0.1159 0.2297
Echinococcus multilocularis lamin dm0 0.0027 0.0089 0.0086
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.003 0.0254
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0062 0.0065
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0166 0.0952 0.8189
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.003 0.0102
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0124 0.0913
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0661 0.4026 0.6637
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0077 0.0074
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0125 0.1257
Brugia malayi follicle stimulating hormone receptor 0.024 0.141 0.1819
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0306
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.0337 0.0525
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.0182 0.1645
Onchocerca volvulus 0.0041 0.0177 0.0159
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0035 0.009
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0071 0.0068
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0177 0.1686
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Brugia malayi MH2 domain containing protein 0.0017 0.0027 0.0019
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0177 0.1381
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0125 0.0122
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.0182 0.0345
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0166 0.0952 0.1223
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0145
Brugia malayi MH2 domain containing protein 0.0017 0.0027 0.0019
Brugia malayi PAS domain containing protein 0.0016 0.002 0.0011
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0174 0.0342
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0131 0.0255
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0152 0.0182
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0166 0.0952 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0177 0.2543
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.0337 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.003 0.0102
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0177 0.023
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.0182 0.0221
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0177 0.0174
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0661 0.4026 0.6637
Echinococcus multilocularis G protein coupled receptor 139 0.0245 0.1442 0.144
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0166 0.0952 1
Leishmania major oxidoreductase, putative 0.0041 0.0177 0.1381
Loa Loa (eye worm) hypothetical protein 0.0101 0.0552 0.081
Brugia malayi AMP-binding enzyme family protein 0.0203 0.1184 0.1525
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Echinococcus granulosus transient receptor potential ion channel A 0.0106 0.0578 0.1149
Echinococcus multilocularis transient receptor potential gamma protein 0.0109 0.0601 0.0598
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0011 0.0008
Echinococcus granulosus ubiquitin specific protease 41 0.0075 0.0386 0.0765
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.0552 0.0853
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.0182 0.0237
Brugia malayi Cathepsin L-like precursor 0.0022 0.0062 0.0065
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.003 0.0228
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.0337 0.0496
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0131 0.0255
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0122
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.0647 0.6719
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.0249 0.0246
Onchocerca volvulus 0.115 0.7064 0.9649
Echinococcus granulosus geminin 0.0524 0.3176 0.6343
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0202 0.1716
Brugia malayi N-terminal motif family protein 0.0186 0.1079 0.1388
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.054 0.3278 0.5384
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Trypanosoma brucei acyl transferase-like protein 0.0042 0.0182 0.1857
Onchocerca volvulus Protein cycle homolog 0.0037 0.0152 0.0124
Loa Loa (eye worm) hypothetical protein 0.0111 0.061 0.0896
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Schistosoma mansoni transient receptor potential channel 4 0.0109 0.0601 0.118
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.0337 0.0423
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0166 0.0952 0.095
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.0337 0.0496
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.0337 0.0496
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0131 0.0128
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Brugia malayi hypothetical protein 0.0052 0.0248 0.0307
Onchocerca volvulus 0.0034 0.0131 0.0095
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.0552 0.0853
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0062 0.0101
Schistosoma mansoni intermediate filament proteins 0.0027 0.0089 0.0156
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0161 0.0925 0.1473
Echinococcus granulosus dna polymerase kappa 0.0019 0.0043 0.008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0035 0.0032
Schistosoma mansoni importin beta-1 0.0032 0.0124 0.0226
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus granulosus AMP dependent ligase 0.0067 0.0337 0.0668
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.0337 0.3264
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0177 0.023
Leishmania major protein kinase, putative 0.002 0.0045 0.0219
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0125 0.1121
Echinococcus multilocularis protein patched 0.0048 0.0218 0.0215
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0334 0.1996 0.4619
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0175 0.0212
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0445
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0177 0.1381
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0702 0.4281 0.7051
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0131 0.0095
Echinococcus multilocularis cpg binding protein 0.0061 0.03 0.0297
Entamoeba histolytica Ran family GTPase 0.0024 0.0071 0.0707
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0035 0.0064
Schistosoma mansoni hypothetical protein 0.0524 0.3176 0.6337
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0124 0.1625
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0125 0.1029
Leishmania major DNA polymerase eta, putative 0.0019 0.0043 0.0201
Echinococcus granulosus importin subunit beta 1 0.0032 0.0124 0.0242
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0022 0.0038
Schistosoma mansoni cpg binding protein 0.0061 0.03 0.0578
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0337 0.5292
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Loa Loa (eye worm) Smad1 0.0017 0.0027 0.0039
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0177 0.023
Schistosoma mansoni transient receptor potential channel 0.0109 0.0601 0.118
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0267 0.1582 0.2565
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0043 0.004
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0617 0.3756 0.5511
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0055
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0035 0.0309
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0177 0.023
Echinococcus granulosus microtubule associated protein 2 0.0687 0.4187 0.8363
Brugia malayi MH2 domain containing protein 0.0246 0.145 0.1871
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0035 0.0064
Echinococcus granulosus transient receptor potential gamma protein 0.0109 0.0601 0.1195
Schistosoma mansoni ran 0.0024 0.0071 0.0119
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0131 0.0095
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0043 0.0007
Brugia malayi isocitrate dehydrogenase 0.0033 0.0125 0.0147
Toxoplasma gondii type I fatty acid synthase 0.0101 0.0552 0.1218
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0688
Toxoplasma gondii cathepsin CPL 0.0034 0.0131 0.0225
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0037 0.015 0.018
Loa Loa (eye worm) hypothetical protein 0.0109 0.0601 0.0881
Echinococcus multilocularis protein dispatched 1 0.0054 0.0259 0.0257
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0177 0.023
Schistosoma mansoni hypothetical protein 0.0346 0.2073 0.4128
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0208 0.1211 0.1949
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Leishmania major acyl carrier protein, putative 0.0067 0.0337 0.2783
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0043 0.0201
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0326
Schistosoma mansoni neuropeptide receptor 0.0245 0.1442 0.2865
Trichomonas vaginalis ran, putative 0.0024 0.0071 0.0583
Leishmania major quinone oxidoreductase, putative 0.0041 0.0177 0.1381
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0478
Loa Loa (eye worm) acetyltransferase 0.0153 0.0872 0.1279
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0661 0.4026 0.6627
Echinococcus granulosus intermediate filament protein 0.0027 0.0089 0.0172
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0124 0.0121
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0535 0.5471
Echinococcus multilocularis smad 0.0017 0.0027 0.0024
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.003 0.0037
Schistosoma mansoni smad 0.0017 0.0027 0.0031
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.0952 1
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0131 0.0239
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0043 0.0007
Mycobacterium leprae Probable oxidireductase 0.0041 0.0177 0.026
Leishmania major cathepsin L-like protease 0.0128 0.0715 0.6106
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.0337 0.3398
Onchocerca volvulus 0.0027 0.0089 0.0038
Echinococcus multilocularis expressed protein 0.0033 0.0129 0.0126
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0131 0.097
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0098
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0182 0.0341
Onchocerca volvulus 0.0034 0.0131 0.0095
Echinococcus multilocularis cysteine protease 0.0034 0.0131 0.0128
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0702 0.4281 0.7051
Loa Loa (eye worm) hypothetical protein 0.0052 0.0248 0.0364
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0661 0.4026 0.6627
Echinococcus multilocularis musashi 0.0027 0.0089 0.0086
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0035 0.0051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.0337 0.0496
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0131 0.1738
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0177 0.1814
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0122
Echinococcus granulosus dnaJ subfamily B 0.0819 0.5006 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.061 1
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0177 0.023
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0166 0.0952 1
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0125 0.0211
Plasmodium falciparum importin beta, putative 0.0032 0.0124 0.1021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.0337 0.0496
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0055
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0715 0.7457
Echinococcus multilocularis dnaJ subfamily B 0.0819 0.5006 0.5004
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0125 0.1257
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.0337 0.0423
Onchocerca volvulus 0.0034 0.0131 0.0095
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0182 0.0179
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0091
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0218 0.0429
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0125 0.0122
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.003 0.0037
Echinococcus multilocularis neuropeptide receptor 0.0245 0.1442 0.144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0177 0.023
Onchocerca volvulus 0.0041 0.0177 0.0159
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0124 0.1114
Trichomonas vaginalis rotamase, putative 0.0033 0.0129 0.1087
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0177 0.1686
Leishmania major GTP-binding protein, putative 0.0024 0.0071 0.0444
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0035 0.0048
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0177 0.023
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0475 0.287 0.4706
Onchocerca volvulus Fatty acid synthase homolog 0.1191 0.7319 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0012 0.0017
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.003 0.0054
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0011 0.0016
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0071 0.0445
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0177 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Loa Loa (eye worm) hypothetical protein 0.0034 0.0131 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0166 0.0952 1
Mycobacterium ulcerans Type I modular polyketide synthase 0.0661 0.4026 0.6627
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0337 0.5292
Onchocerca volvulus 0.0071 0.0361 0.0412
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.0872 0.0869
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0086 0.0714
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0702 0.4281 0.7051
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0129 0.1087
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0035 0.0161
Echinococcus granulosus cpg binding protein 0.0061 0.03 0.0593
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0208 0.1211 0.1974
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0033 0.006
Loa Loa (eye worm) ctsf protein 0.0034 0.0131 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Echinococcus granulosus neuropeptide receptor 0.0245 0.1442 0.2877
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0075 0.0386 0.0765
Loa Loa (eye worm) acyl carrier protein 0.0067 0.0337 0.0495
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0661 0.4026 0.6627
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0242 0.03
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0988 0.6055 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0266
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0349
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0043 0.0064
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0202 0.0397
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0182 0.0341
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.145 0.2128
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0043 0.0041
Onchocerca volvulus 0.0034 0.0131 0.0095
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0177 0.023
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.003 0.0102
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.0337 0.0496
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.0552 0.0881
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0035 0.0158
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0035 0.013
Echinococcus multilocularis Smad4 0.0017 0.0027 0.0024
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0386 0.3922
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0218 0.0215
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0131 0.0128
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0177 0.026
Schistosoma mansoni transient receptor potential channel 0.0072 0.0371 0.072
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0177 0.1686
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0086 0.0714
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0178 0.1277
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0243
Chlamydia trachomatis acyl carrier protein 0.0067 0.0337 0.3398
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.0337 0.0379
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0437 0.2636 0.4334
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0177 0.0333
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0039 0.0163
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.0182 0.1645
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0027 0.0039
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0429 0.2584 0.6005
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0075 0.0386 0.3212
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.0337 0.3499
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0227 0.1333 0.2151
Schistosoma mansoni Smad4 0.0017 0.0027 0.0031
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0182 0.0357
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0011 0.0016
Entamoeba histolytica cysteine protease, putative 0.0034 0.0131 0.1738
Brugia malayi MH1 domain containing protein 0.0017 0.0027 0.0019
Brugia malayi cathepsin L-like precursor 0.0022 0.0062 0.0065
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0177 0.023
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0166 0.0952 0.1898
Onchocerca volvulus 0.0027 0.0089 0.0038
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0177 0.1686
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.0845 0.1683
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.061 0.1214
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.0715 0.7457
Loa Loa (eye worm) fibroinase 0.0034 0.0131 0.0192
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.013
Echinococcus multilocularis cathepsin L 0.0017 0.003 0.0027
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0131 0.1093
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.002 0.0145
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0177 0.023
Echinococcus multilocularis expressed conserved protein 0.0104 0.0569 0.0566
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0124 0.1114
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0131 0.0095
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0089 0.0131
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0239
Schistosoma mansoni DNA polymerase eta 0.0019 0.0043 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0043 0.0063
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0075 0.0386 0.0383
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0125 0.0147
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0532 0.3224 0.5294
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0075 0.0386 0.0765
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0177 0.023
Treponema pallidum acyl carrier protein 0.0067 0.0337 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0284 0.0417
Schistosoma mansoni single-minded 0.0016 0.002 0.0018
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0177 0.023
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0145
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.003 0.0023
Schistosoma mansoni smad1 5 8 and 0.0017 0.0027 0.0031
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0043 0.0007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0035 0.0309
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0202 0.0393
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0075 0.0386 0.0383
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0043 0.0064
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0091
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0337 0.0496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.0952 0.1519
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.0952 0.1519
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0641 0.39 0.6418
Echinococcus granulosus expressed protein 0.0033 0.0129 0.0252
Mycobacterium tuberculosis Probable thioesterase TesA 0.0551 0.3342 0.549
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0131 0.0192
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0077 0.0753
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0386 0.3311
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0131 0.1185
Loa Loa (eye worm) acyl carrier protein 0.0304 0.1809 0.2655
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0535 0.5471
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0131 0.1738
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.0872 0.1118
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0177 0.023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0035 0.003
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0532 0.3224 0.5294
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0077 0.0637
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0022 0.0021
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0202 0.0393
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0043 0.004
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0152 0.0281
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0386 0.3922
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0077 0.0609
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.0158
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0125 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus granulosus Smad4 0.0017 0.0027 0.0047
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0125 0.0918
Giardia lamblia Methyltransferase like 2 0.0199 0.1159 1
Entamoeba histolytica hypothetical protein 0.0025 0.0077 0.0813
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0702 0.4281 0.7051
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0177 0.1686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.032
Onchocerca volvulus 0.0052 0.0248 0.0256
Loa Loa (eye worm) hypothetical protein 0.0186 0.1079 0.1583
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus granulosus lamin 0.0027 0.0089 0.0172
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0033 0.0048
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0035 0.0032
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0546 0.5637
Onchocerca volvulus 0.0617 0.3756 0.509
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0145
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0337 0.0496
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.061 0.0608
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.0182 0.1563
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0218 0.032
Brugia malayi CXXC zinc finger family protein 0.0057 0.028 0.0348
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0043 0.0344
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0177 0.023
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0043 0.0246
Mycobacterium ulcerans oxidoreductase 0.0041 0.0177 0.023
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0177 0.0159
Brugia malayi MH1 domain containing protein 0.0017 0.0027 0.0019
Echinococcus granulosus snurportin 1 0.0346 0.2073 0.4138
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0177 0.1506
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Schistosoma mansoni hypothetical protein 0.0819 0.5006 1
Schistosoma mansoni ran 0.0024 0.0071 0.0119
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0004
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0177 0.1506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0337 0.0496
Mycobacterium ulcerans polyketide synthase MbtC 0.0166 0.0952 0.1519
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0077
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0462
Schistosoma mansoni smad1 5 8 and 0.0017 0.0027 0.0031
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0175 0.0172
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0043 0.0344
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0086 0.0705
Loa Loa (eye worm) hypothetical protein 0.111 0.6815 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0702 0.4281 0.706
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0039 0.0034
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.0249 0.0366
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0177 0.0349
Leishmania major hypothetical protein, conserved 0.0042 0.0182 0.1417
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.061 0.0779
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0177 0.2543
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0043 0.0007
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0124 0.021
Plasmodium vivax vivapain-2 0.0034 0.0131 0.1093
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0177 0.0215
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.002 0.0145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0035 0.003
Plasmodium vivax importin-beta 2, putative 0.0032 0.0124 0.1021
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0077 0.0099
Schistosoma mansoni hypothetical protein 0.0524 0.3176 0.6337
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.0337 0.0496
Onchocerca volvulus 0.0057 0.028 0.03
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.0337 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0131 0.0128
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0337 0.0525
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.0182 0.1731
Echinococcus multilocularis geminin 0.0524 0.3176 0.3174
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0035 0.0309
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0371 0.0736
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.003
Schistosoma mansoni lamin 0.0027 0.0089 0.0156
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0131 0.1101
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0062 0.0553
Brugia malayi CHE-14 protein 0.0048 0.0218 0.0268
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0131 0.0192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0641 0.39 0.6418
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0177 0.023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.0386 0.3311
Giardia lamblia DINP protein human, muc B family 0.0019 0.0043 0.0073
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0199
Schistosoma mansoni acyl carrier protein 0.0067 0.0337 0.0652
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0371 0.0368
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0337 0.0496
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0174 0.0171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Echinococcus multilocularis ubiquitin specific protease 41 0.0075 0.0386 0.0383
Mycobacterium ulcerans polyketide synthase Pks9 0.0437 0.2636 0.4317
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0702 0.4281 0.7051
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0715 0.7457
Leishmania major cathepsin L-like protease 0.0128 0.0715 0.6106
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0125 0.0183
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.0337 0.0334
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0319
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0177 0.023
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0027 0.0047
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0177 0.2543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0337 0.0334
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0125 0.0211
Mycobacterium ulcerans Type I modular polyketide synthase 0.0661 0.4026 0.6627
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0202 0.1863
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0104
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0202 0.1716
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0177 0.0336
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Brugia malayi RNA, U transporter 1 0.0092 0.0495 0.0629
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0124 0.1249
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0702 0.4281 0.706
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0071 0.0084
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0022 0.0019
Entamoeba histolytica hypothetical protein 0.0026 0.0086 0.0967
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0166 0.0952 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Brugia malayi hypothetical protein 0.004 0.0174 0.0211
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.0906 0.0903
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0306
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.0249 0.0492
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0027 0.0024
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0075 0.0386 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.0182 0.1731
Mycobacterium ulcerans polyketide synthase 0.0702 0.4281 0.7051
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0166 0.0952 0.1884
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.0309
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0182 0.0341
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.4187 0.8361
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0011 0.0008
Echinococcus granulosus cathepsin l1 0.0022 0.0062 0.0118
Schistosoma mansoni transient receptor potential channel 0.0072 0.0371 0.072
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0145
Brugia malayi hypothetical protein 0.0037 0.0152 0.0182
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0075 0.0386 0.3123
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0203 0.1184 0.1904
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0035 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0177 0.0336
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0543
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0041 0.0177 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0039 0.0057
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.0337 0.0711
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0145
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0462
Brugia malayi intermediate filament protein 0.0027 0.0089 0.0101
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0178 0.2561
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0041 0.0177 0.026
Echinococcus multilocularis transient receptor potential ion channel A 0.0106 0.0578 0.0575
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0043 0.0395
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0035 0.0051
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.0952 1
Brugia malayi Smad1 0.0017 0.0027 0.0019
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0166 0.0952 0.1398
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0178 0.1611
Echinococcus granulosus lamin dm0 0.0027 0.0089 0.0172
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0386 0.4015
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0075 0.0386 0.075
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0077 0.0148
Onchocerca volvulus 0.0034 0.0131 0.0095
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.0337 0.0668
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0988 0.6055 1
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0661 0.4026 0.5221
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0027 0.0024
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0218 0.0429
Echinococcus multilocularis dna polymerase eta 0.0019 0.0043 0.004
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.003 0.0228
Mycobacterium ulcerans Type I modular polyketide synthase 0.0661 0.4026 0.6627
Mycobacterium ulcerans oxidoreductase 0.0041 0.0177 0.023
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0145
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.0337 0.0423
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0077 0.0132
Plasmodium vivax vivapain-2 0.0034 0.0131 0.1093
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0177 0.1381
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0035 0.0309
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0055 0.0377
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0177 0.023
Plasmodium falciparum acyl carrier protein 0.0067 0.0337 0.333
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0041 0.0177 0.026
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0131
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0478
Echinococcus granulosus NADH dehydrogenase 0.0067 0.0337 0.0668
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0177 0.0333
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0551 0.3342 0.5504
Mycobacterium ulcerans dehydrogenase 0.0041 0.0177 0.023
Loa Loa (eye worm) hypothetical protein 0.0075 0.0386 0.0566
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.0337 0.0496
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0125 0.0227
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.0552 0.0853
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0177 0.023
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0086 0.0714
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0177 0.023
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0071 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0043 0.0041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni lamin 0.0027 0.0089 0.0156
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0337 0.0496
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0125 0.1121
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0371 0.0736
Schistosoma mansoni smad1 5 8 and 0.0017 0.0027 0.0031
Mycobacterium tuberculosis Conserved protein 0.0199 0.1159 0.1861
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0035 0.013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0033 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Brugia malayi Importin beta-1 subunit 0.0032 0.0124 0.0146
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0089 0.0131
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.1855
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0177 0.0215
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0437 0.2636 0.4317
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0177 0.1814
Plasmodium vivax acyl carrier protein, putative 0.0067 0.0337 0.333
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.003 0.0254
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0371 0.0368
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0177 0.0215
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0622 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trichomonas vaginalis rotamase, putative 0.0032 0.0124 0.1045
Echinococcus granulosus cysteine protease 0.0017 0.003 0.0054
Toxoplasma gondii type I fatty acid synthase, putative 0.047 0.2843 0.6615
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0127
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0129 0.0152
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0035 0.0158
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.0906 0.1804
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0239
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1253 0.77 1
Leishmania major hypothetical protein, conserved 0.0199 0.1159 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus granulosus dna polymerase eta 0.0019 0.0043 0.008
Brugia malayi Cathepsin L-like precursor 0.0022 0.0062 0.0065
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0131 0.0128
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0129 0.0189
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.003 0.0023
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.2073 0.3042
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0177 0.1517
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0177 0.1814
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0145
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Echinococcus multilocularis snurportin 1 0.0346 0.2073 0.2071
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0043 0.0231
Echinococcus granulosus expressed conserved protein 0.0104 0.0569 0.1131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0462
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Toxoplasma gondii exonuclease III APE 0.0019 0.0039 0.0009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.0337 0.0334
Loa Loa (eye worm) hypothetical protein 0.0101 0.0552 0.081
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0621 0.1221
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0177 0.023
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.0872 0.1723
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0027 0.0039
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Leishmania major importin beta-1 subunit, putative 0.0026 0.0086 0.0577
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0152 0.0182
Mycobacterium tuberculosis Hypothetical protein 0.0199 0.1159 0.1861
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0124 0.021
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0131 0.0239
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0035 0.013
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0039 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0337 0.0496
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0131 0.1093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0062 0.0506
Mycobacterium ulcerans fatty acid synthase Fas 0.0208 0.1211 0.1949
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0122
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.4187 0.4185
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0337 0.0525
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0177 0.023
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0039 0.0156
Brugia malayi hypothetical protein 0.0037 0.015 0.018
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0532 0.3224 0.5309
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0035 0.0158
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0182
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0077 0.0085
Mycobacterium leprae Probable polyketide synthase Pks1 0.0702 0.4281 0.706
Schistosoma mansoni hypothetical protein 0.0067 0.0337 0.0652
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0543
Loa Loa (eye worm) cysteine protease 0.0034 0.0131 0.0192
Loa Loa (eye worm) hypothetical protein 0.0041 0.0175 0.0256
Loa Loa (eye worm) hypothetical protein 0.037 0.2221 0.3259
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Onchocerca volvulus 0.0034 0.0131 0.0095
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0075 0.0386 0.075
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.003 0.0102
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0177 0.023
Echinococcus granulosus cathepsin l1 0.0034 0.0131 0.0255
Brugia malayi Methyltransferase-like protein 4 0.0199 0.1159 0.1492
Leishmania major cathepsin L-like protease 0.0128 0.0715 0.6106
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0177 0.1381
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0035 0.013
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0177 0.1506
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0075 0.0386 0.6133
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0337 0.0496
Leishmania major DNA polymerase kappa, putative 0.0019 0.0043 0.0201
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0166 0.0952 0.2161
Mycobacterium ulcerans polyketide synthase MbtD 0.0203 0.1184 0.1904
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.003 0.0037
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.1079 0.1402
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0376 0.2255 0.3684
Onchocerca volvulus 0.0034 0.0131 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0089 0.0101
Loa Loa (eye worm) hypothetical protein 0.0037 0.0152 0.0223
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0242 0.0355
Toxoplasma gondii type I fatty acid synthase, putative 0.0702 0.4281 1
Schistosoma mansoni patched 1 0.0048 0.0218 0.0413

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.