Detailed information for compound 1543553

Basic information

Technical information
  • TDR Targets ID: 1543553
  • Name: N-(4-methylphenyl)-N-[2-oxo-2-(phenylmethylam ino)ethyl]thiadiazole-4-carboxamide
  • MW: 366.437 | Formula: C19H18N4O2S
  • H donors: 1 H acceptors: 4 LogP: 3 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN(C(=O)c1csnn1)c1ccc(cc1)C)NCc1ccccc1
  • InChi: 1S/C19H18N4O2S/c1-14-7-9-16(10-8-14)23(19(25)17-13-26-22-21-17)12-18(24)20-11-15-5-3-2-4-6-15/h2-10,13H,11-12H2,1H3,(H,20,24)
  • InChiKey: HXMUNIBCTUFUHZ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(4-methylphenyl)-N-[2-oxo-2-(phenylmethylamino)ethyl]-4-thiadiazolecarboxamide
  • N-[2-(benzylamino)-2-keto-ethyl]-N-(4-methylphenyl)thiadiazole-4-carboxamide
  • N-(4-methylphenyl)-N-[2-oxo-2-(phenylmethylamino)ethyl]-1,2,3-thiadiazole-4-carboxamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225

By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.0158
Mycobacterium ulcerans fatty-acid-CoA ligase FadD9 0.0067 0.0337 0.0496
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0035 0.013
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0306
Echinococcus multilocularis smad 0.0017 0.0027 0.0024
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0177 0.023
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0429 0.2584 0.6005
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0166 0.0952 0.2161
Schistosoma mansoni zinc binding dehydrogenase 0.0041 0.0177 0.0333
Echinococcus multilocularis microtubule associated protein 2 0.0687 0.4187 0.4185
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0177 0.1686
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0337 0.5292
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0067 0.0337 0.0496
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0067 0.0337 0.0525
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0702 0.4281 0.706
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Schistosoma mansoni transient receptor potential channel 0.0072 0.0371 0.072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0122
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0035 0.0051
Echinococcus multilocularis dna polymerase eta 0.0019 0.0043 0.004
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0177 0.1506
Schistosoma mansoni methyltransferase-related 0.0199 0.1159 0.2297
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.0174 0.0342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0043 0.0007
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0037 0.0152 0.0223
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0098
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni hypothetical protein 0.0067 0.0337 0.0652
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0125 0.0143
Trypanosoma cruzi importin beta-1 subunit, putative 0.0026 0.0086 0.0705
Brugia malayi aryl hydrocarbon receptor nuclear translocator protein, putative 0.0037 0.0152 0.0182
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0177 0.1814
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0177 0.0215
Leishmania major NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0177 0.1381
Echinococcus multilocularis Niemann Pick C1 protein 0.0158 0.0906 0.0903
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0125 0.0918
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0334 0.1996 0.4619
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0641 0.39 0.6418
Toxoplasma gondii type I fatty acid synthase 0.0101 0.0552 0.1218
Mycobacterium tuberculosis S-nitrosomycothiol reductase MscR 0.0041 0.0177 0.023
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0988 0.6055 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0039 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Mycobacterium ulcerans quinone reductase Qor 0.0041 0.0177 0.023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0131 0.0128
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0125 0.0211
Schistosoma mansoni transient receptor potential channel 0.0072 0.0371 0.072
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0039 0.0036
Schistosoma mansoni hypothetical protein 0.0524 0.3176 0.6337
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0067 0.0337 0.0496
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0089 0.0131
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0131 0.0239
Brugia malayi hypothetical protein 0.0037 0.0152 0.0182
Leishmania major cathepsin L-like protease 0.0128 0.0715 0.6106
Echinococcus granulosus serine protein kinase ATM 0.0025 0.0077 0.0148
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0101 0.0552 0.0853
Trypanosoma brucei Trans-2-enoyl-ACP reductase 2, putative 0.0041 0.0177 0.1814
Echinococcus multilocularis expressed conserved protein 0.0104 0.0569 0.0566
Loa Loa (eye worm) hypothetical protein 0.0069 0.0348 0.0511
Brugia malayi MH1 domain containing protein 0.0017 0.0027 0.0019
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0027 0.0047
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0131 0.0128
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0178 0.1611
Loa Loa (eye worm) hypothetical protein 0.0026 0.0086 0.0127
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0202 0.0393
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0035 0.0309
Leishmania major importin beta-1 subunit, putative 0.0026 0.0086 0.0577
Brugia malayi follicle stimulating hormone receptor 0.024 0.141 0.1819
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0101 0.0552 0.0853
Mycobacterium tuberculosis Probable alcohol dehydrogenase Adh 0.0041 0.0177 0.023
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.003 0.0102
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0034 0.0131 0.1093
Echinococcus granulosus Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0182 0.0357
Loa Loa (eye worm) acyl carrier protein 0.0067 0.0337 0.0495
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.0386 0.3311
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0041 0.0175 0.0172
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Onchocerca volvulus 0.0034 0.0131 0.0095
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.003 0.0023
Brugia malayi AMP-binding enzyme family protein 0.0617 0.3756 0.487
Toxoplasma gondii histone lysine methyltransferase SET1 0.0113 0.0622 0.1383
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0177 0.1686
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0089 0.0131
Onchocerca volvulus 0.0617 0.3756 0.509
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0039 0.0098
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0043 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0091
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0075 0.0386 0.0383
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0131 0.0095
Mycobacterium ulcerans Type I modular polyketide synthase 0.0661 0.4026 0.6627
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0027 0.0024
Echinococcus granulosus TRP transient receptor potential channel 0.0041 0.0175 0.0343
Schistosoma mansoni microtubule-associated protein tau 0.0687 0.4187 0.8361
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0617 0.3756 0.5511
Echinococcus multilocularis Acyl carrier protein, mitochondrial 0.0067 0.0337 0.0334
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.0022 0.0019
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.054 0.3278 0.5384
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0177 0.2543
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.003 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Wolbachia endosymbiont of Brugia malayi acyl carrier protein 0.0067 0.0337 0.3264
Echinococcus multilocularis snurportin 1 0.0346 0.2073 0.2071
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0218 0.0215
Echinococcus multilocularis aryl hydrocarbon receptor 0.0053 0.0249 0.0246
Loa Loa (eye worm) hypothetical protein 0.0034 0.0131 0.0192
Onchocerca volvulus 0.115 0.7064 0.9649
Mycobacterium ulcerans hypothetical protein 0.0067 0.0337 0.0496
Chlamydia trachomatis malonyl CoA-ACP transacylase 0.0042 0.0182 0.1731
Onchocerca volvulus 0.0041 0.0177 0.0159
Brugia malayi AMP-binding enzyme family protein 0.0203 0.1184 0.1525
Schistosoma mansoni lamin 0.0027 0.0089 0.0156
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Trypanosoma brucei Acyl carrier protein, mitochondrial 0.0067 0.0337 0.3499
Echinococcus granulosus cathepsin l cysteine peptidase 0.0034 0.0131 0.0255
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase AdhE2 0.0041 0.0177 0.023
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus granulosus mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0177 0.0349
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0125 0.0183
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0043 0.0395
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0208 0.1211 0.1949
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0043 0.004
Echinococcus granulosus transient receptor potential gamma protein 0.0109 0.0601 0.1195
Mycobacterium ulcerans zinc-type alcohol dehydrogenase AdhD 0.0041 0.0177 0.023
Leishmania major zinc-binding dehydrogenase-like protein 0.0041 0.0177 0.1381
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0202 0.0397
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Mycobacterium tuberculosis Acyl carrier protein (ACP) MbtL 0.0067 0.0337 0.0496
Mycobacterium ulcerans malonyl CoA-acyl carrier protein transacylase FabD 0.0042 0.0182 0.0237
Loa Loa (eye worm) hypothetical protein 0.0075 0.0386 0.0566
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0166 0.0952 1
Brugia malayi ADP-specific Phosphofructokinase/Glucokinase conserved region family protein 0.0042 0.0182 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.061 0.0608
Loa Loa (eye worm) acyl carrier protein 0.0304 0.1809 0.2655
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0186 0.1079 0.1402
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Loa Loa (eye worm) ctsf protein 0.0034 0.0131 0.0192
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0027 0.0039
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0011 0.0008
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0071 0.0445
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0101 0.0552 0.0853
Mycobacterium ulcerans Zn-dependent alcohol dehydrogenase, AdhX 0.0041 0.0177 0.023
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0688
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0445
Brugia malayi Importin beta-1 subunit 0.0032 0.0124 0.0146
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0124 0.1249
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0532 0.3224 0.5294
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0035 0.009
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0043 0.0007
Brugia malayi CHE-14 protein 0.0048 0.0218 0.0268
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0702 0.4281 0.7051
Brugia malayi Smad1 0.0017 0.0027 0.0019
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0371 0.0368
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.003 0.0037
Echinococcus granulosus neuropeptide receptor 0.0245 0.1442 0.2877
Trypanosoma cruzi major cysteine proteinase, putative 0.01 0.0546 0.5637
Brugia malayi Phosphopantetheine attachment site family protein 0.0067 0.0337 0.0423
Loa Loa (eye worm) hypothetical protein 0.0041 0.0175 0.0256
Loa Loa (eye worm) fibroinase 0.0034 0.0131 0.0192
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0227 0.1333 0.2151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0035 0.013
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0043 0.0246
Echinococcus multilocularis mitochondrial trans 2 enoyl coenzyme A reductase 0.0041 0.0177 0.0174
Loa Loa (eye worm) cysteine protease 0.0034 0.0131 0.0192
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0702 0.4281 0.7051
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0124 0.1251
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.061 1
Entamoeba histolytica NADP-dependent alcohol dehydrogenase, putative 0.0041 0.0177 0.2543
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0153 0.0872 0.0869
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0124 0.1114
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Mycobacterium leprae conserved hypothetical protein 0.0067 0.0337 0.0525
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0067 0.0337 0.0496
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0661 0.4026 0.6627
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0043 0.0344
Echinococcus multilocularis lamin 0.0027 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0091
Schistosoma mansoni smad 0.0017 0.0027 0.0031
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0017 0.003 0.0102
Trichomonas vaginalis ran, putative 0.0024 0.0071 0.0583
Echinococcus multilocularis expressed protein 0.0033 0.0129 0.0126
Schistosoma mansoni acyl carrier protein 0.0067 0.0337 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni Smad4 0.0017 0.0027 0.0031
Brugia malayi CXXC zinc finger family protein 0.0057 0.028 0.0348
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0177 0.023
Leishmania major DNA polymerase kappa, putative 0.0019 0.0043 0.0201
Loa Loa (eye worm) hypothetical protein 0.0019 0.0043 0.0063
Loa Loa (eye worm) hypothetical protein 0.0013 0.0003 0.0004
Onchocerca volvulus 0.0034 0.0131 0.0095
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.003 0.0102
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0043 0.0064
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0037 0.015 0.018
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0075 0.0386 0.075
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0039 0.0199
Schistosoma mansoni rotamase 0.0033 0.0129 0.0236
Echinococcus granulosus cathepsin l1 0.0034 0.0131 0.0255
Onchocerca volvulus 0.0027 0.0089 0.0038
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0153 0.0872 0.1723
Entamoeba histolytica acyl-CoA synthetase, putative 0.0067 0.0337 0.5292
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0062 0.0506
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0055
Mycobacterium tuberculosis Hypothetical protein 0.0199 0.1159 0.1861
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0462
Echinococcus multilocularis ubiquitin specific protease 41 0.0075 0.0386 0.0383
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Onchocerca volvulus Putative alcohol dehydrogenase 0.0041 0.0177 0.0159
Brugia malayi Cathepsin L-like precursor 0.0022 0.0062 0.0065
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.003 0.0228
Loa Loa (eye worm) hypothetical protein 0.0032 0.0124 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni aryl hydrocarbon receptor 0.0016 0.0022 0.0021
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0437 0.2636 0.4317
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.0022 0.0038
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0033 0.003
Mycobacterium tuberculosis Meromycolate extension acyl carrier protein AcpM 0.0067 0.0337 0.0496
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0202 0.1716
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0035 0.0309
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0039 0.0072
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0475 0.287 0.4706
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0202 0.1716
Wolbachia endosymbiont of Brugia malayi ACP S-malonyltransferase 0.0042 0.0182 0.1563
Leishmania major hypothetical protein, conserved 0.0042 0.0182 0.1417
Schistosoma mansoni lamin 0.0027 0.0089 0.0156
Loa Loa (eye worm) hypothetical protein 0.0052 0.0248 0.0364
Echinococcus granulosus cathepsin l1 0.0022 0.0062 0.0118
Plasmodium vivax malonyl CoA-acyl carrier protein transacylase precursor, putative 0.0042 0.0182 0.1645
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0035 0.013
Echinococcus granulosus Smad4 0.0017 0.0027 0.0047
Brugia malayi acyl carrier protein, mitochondrial precursor, putative 0.0067 0.0337 0.0423
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0199
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0025 0.0077 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0077 0.0637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.061 0.1214
Toxoplasma gondii acyl transferase domain-containing protein 0.0042 0.0182 0.0345
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0661 0.4026 0.6627
Brugia malayi MH1 domain containing protein 0.0017 0.0027 0.0019
Loa Loa (eye worm) hypothetical protein 0.037 0.2221 0.3259
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0125 0.1121
Echinococcus granulosus AMP dependent ligase 0.0067 0.0337 0.0668
Plasmodium falciparum malonyl CoA-acyl carrier protein transacylase 0.0042 0.0182 0.1645
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0043 0.0007
Echinococcus granulosus microtubule associated protein 2 0.0687 0.4187 0.8363
Echinococcus granulosus lamin dm0 0.0027 0.0089 0.0172
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0182 0.0341
Schistosoma mansoni aryl hydrocarbon receptor nuclear translocator homolog (darnt) 0.0037 0.0152 0.0281
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0641 0.39 0.6418
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0462
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0166 0.0952 0.8189
Mycobacterium ulcerans oxidoreductase 0.0041 0.0177 0.023
Echinococcus multilocularis serine protein kinase ATM 0.0025 0.0077 0.0074
Mycobacterium ulcerans oxidoreductase 0.0041 0.0177 0.023
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0988 0.6055 1
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0035 0.0051
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0166 0.0952 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0182 0.0266
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0055 0.0377
Mycobacterium tuberculosis Probable quinone reductase Qor (NADPH:quinone reductase) (zeta-crystallin homolog protein) 0.0041 0.0177 0.023
Leishmania major GTP-binding protein, putative 0.0024 0.0071 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0129 0.1087
Mycobacterium tuberculosis Probable thioesterase TesA 0.0551 0.3342 0.549
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0043 0.0344
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Mycobacterium ulcerans thioesterase 0.0551 0.3342 0.549
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Chlamydia trachomatis acyl carrier protein 0.0067 0.0337 0.3398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0043 0.0064
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0202 0.0393
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0239
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Trichomonas vaginalis rotamase, putative 0.0033 0.0129 0.1087
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0551 0.3342 0.5504
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0145
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0035 0.0132
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Trypanosoma brucei importin beta-1 subunit, putative 0.0032 0.0124 0.1249
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0543
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0218 0.0429
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0025 0.0077 0.0609
Leishmania major DNA polymerase eta, putative 0.0019 0.0043 0.0201
Leishmania major acyl carrier protein, putative 0.0067 0.0337 0.2783
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0035 0.0158
Leishmania major oxidoreductase-like protein 0.0041 0.0177 0.1381
Leishmania major hypothetical protein, conserved 0.0199 0.1159 1
Echinococcus multilocularis cysteine protease 0.0034 0.0131 0.0128
Onchocerca volvulus Fatty acid synthase homolog 0.1191 0.7319 1
Echinococcus granulosus cathepsin L cysteine protease 0.0017 0.003 0.0054
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0035 0.003
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0039 0.0035
Toxoplasma gondii type I fatty acid synthase, putative 0.0702 0.4281 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Treponema pallidum acyl carrier protein 0.0067 0.0337 1
Chlamydia trachomatis 3-oxoacyl-ACP synthase 0.0166 0.0952 1
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0371 0.0736
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0122
Echinococcus granulosus snurportin 1 0.0346 0.2073 0.4138
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0086 0.0714
Schistosoma mansoni transient receptor potential channel 4 0.0109 0.0601 0.118
Schistosoma mansoni transient receptor potential channel 0.0109 0.0601 0.118
Plasmodium falciparum cysteine proteinase falcipain 3 0.0034 0.0131 0.1093
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.003 0.0023
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0033 0.0048
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0131 0.1738
Schistosoma mansoni ran 0.0024 0.0071 0.0119
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0208 0.1211 0.1974
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.0952 0.1519
Echinococcus multilocularis importin subunit beta 1 0.0032 0.0124 0.0121
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0702 0.4281 0.706
Brugia malayi MH2 domain containing protein 0.0017 0.0027 0.0019
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0101 0.0552 0.0881
Mycobacterium tuberculosis Probable NADPH quinone oxidoreductase FadB4 (NADPH:quinone reductase) (zeta-crystallin) 0.0041 0.0177 0.023
Echinococcus granulosus cathepsin L 0.0017 0.003 0.0054
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0715 0.7457
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0166 0.0952 1
Brugia malayi intermediate filament protein 0.0027 0.0089 0.0101
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0125 0.0147
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0039 0.0156
Schistosoma mansoni alcohol dehydrogenase 0.0041 0.0177 0.0333
Brugia malayi Alcohol dehydrogenase class III 0.0041 0.0177 0.0215
Brugia malayi hypothetical protein 0.004 0.0174 0.0211
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0075 0.0386 0.0486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Schistosoma mansoni neuropeptide receptor 0.0245 0.1442 0.2865
Echinococcus multilocularis cpg binding protein 0.0061 0.03 0.0297
Echinococcus granulosus cpg binding protein 0.0061 0.03 0.0593
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Onchocerca volvulus Protein cycle homolog 0.0037 0.0152 0.0124
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0177 0.1686
Echinococcus multilocularis transient receptor potential gamma protein 0.0109 0.0601 0.0598
Trichomonas vaginalis guanylate cyclase, putative 0.0016 0.002 0.0145
Plasmodium falciparum importin beta, putative 0.0032 0.0124 0.1021
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0039 0.0057
Mycobacterium tuberculosis Probable zinc-type alcohol dehydrogenase AdhD (aldehyde reductase) 0.0041 0.0177 0.023
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Mycobacterium ulcerans quinone oxidoreductase 0.0041 0.0177 0.023
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0035 0.0158
Mycobacterium leprae Probable alcohol dehydrogenase AdhA 0.0041 0.0177 0.026
Echinococcus multilocularis protein patched 0.0048 0.0218 0.0215
Schistosoma mansoni ran 0.0024 0.0071 0.0119
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0027 0.0039
Schistosoma mansoni smad1 5 8 and 0.0017 0.0027 0.0031
Loa Loa (eye worm) hypothetical protein 0.0109 0.0601 0.0881
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0035 0.0309
Echinococcus granulosus geminin 0.0524 0.3176 0.6343
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0053 0.0249 0.0366
Mycobacterium tuberculosis Probable acyl carrier protein AcpA (ACP) 0.0067 0.0337 0.0496
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD dependent AdhB 0.0041 0.0177 0.023
Trypanosoma brucei oxidoreductase, putative 0.0041 0.0177 0.1814
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0177 0.1506
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0071 0.0068
Mycobacterium leprae Probable S-nitrosomycothiol reductase MscR 0.0041 0.0177 0.026
Trypanosoma cruzi acyl transferase-like protein 0.0042 0.0182 0.1731
Loa Loa (eye worm) acetyltransferase 0.0153 0.0872 0.1279
Plasmodium vivax vivapain-2 0.0034 0.0131 0.1093
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0075 0.0386 0.0765
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.0952 1
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0043 0.008
Brugia malayi MH2 domain containing protein 0.0017 0.0027 0.0019
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0337 0.0496
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0016 0.002 0.0145
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0124 0.1625
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0178 0.1277
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0124 0.0913
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Schistosoma mansoni transcription factor LCR-F1 0.004 0.0174 0.0326
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0104
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Brugia malayi acetyltransferase, GNAT family protein 0.0153 0.0872 0.1118
Echinococcus granulosus cathepsin L cysteine proteinase 0.0034 0.0131 0.0255
Echinococcus multilocularis NADH dehydrogenase 0.0067 0.0337 0.0334
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0122
Echinococcus granulosus aryl hydrocarbon receptor 0.0053 0.0249 0.0492
Echinococcus granulosus importin subunit beta 1 0.0032 0.0124 0.0242
Leishmania major cathepsin L-like protease 0.0128 0.0715 0.6106
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0101 0.0552 0.0853
Brugia malayi cathepsin L-like precursor 0.0022 0.0062 0.0065
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0043 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0199 0.1159 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0129 0.0189
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Leishmania major cysteine peptidase A (CPA) 0.0034 0.0131 0.097
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0099 0.0535 0.5471
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0011 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0702 0.4281 0.7051
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.003 0.0254
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0071 0.0136
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0617 0.3756 0.6179
Toxoplasma gondii acyl carrier protein ACP 0.0067 0.0337 0.0711
Onchocerca volvulus 0.0034 0.0131 0.0095
Mycobacterium ulcerans oxidoreductase FadB5 0.0041 0.0177 0.023
Echinococcus multilocularis neuropeptide receptor 0.0245 0.1442 0.144
Plasmodium vivax vivapain-2 0.0034 0.0131 0.1093
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0075 0.0386 0.0383
Entamoeba histolytica hypothetical protein 0.004 0.0174 0.2483
Brugia malayi PAS domain containing protein 0.0016 0.002 0.0011
Onchocerca volvulus 0.0027 0.0089 0.0038
Plasmodium falciparum acyl carrier protein 0.0067 0.0337 0.333
Schistosoma mansoni smad1 5 8 and 0.0017 0.0027 0.0031
Mycobacterium ulcerans polyketide synthase 0.0661 0.4026 0.6627
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.003 0.0228
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0532 0.3224 0.5309
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Onchocerca volvulus 0.0041 0.0177 0.0159
Echinococcus multilocularis Malonyl coenzyme A acyl carrier protein transacylase 0.0042 0.0182 0.0179
Echinococcus multilocularis transient receptor potential ion channel A 0.0106 0.0578 0.0575
Schistosoma mansoni hypothetical protein 0.004 0.0174 0.0326
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0125 0.1029
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0035 0.0048
Trichomonas vaginalis conserved hypothetical protein 0.0016 0.002 0.0145
Onchocerca volvulus 0.0057 0.028 0.03
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0661 0.4026 0.6627
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0124 0.021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Trypanosoma cruzi cysteine proteinase, putative 0.0017 0.003 0.0102
Entamoeba histolytica hypothetical protein 0.0025 0.0077 0.0813
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0022 0.0062 0.0506
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0203 0.1184 0.1904
Schistosoma mansoni cathepsin F (C01 family) 0.0034 0.0131 0.0239
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.0158
Onchocerca volvulus Cathepsin L homolog 0.0034 0.0131 0.0095
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0075 0.0386 0.6133
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0437 0.2636 0.4334
Trypanosoma cruzi acyl transferase-like protein, putative 0.0042 0.0182 0.1731
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase Adh 0.0041 0.0177 0.023
Schistosoma mansoni intermediate filament proteins 0.0027 0.0089 0.0156
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Mycobacterium tuberculosis Probable NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0177 0.023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.0242 0.0239
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0532 0.3224 0.5294
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0166 0.0952 0.1898
Leishmania major quinone oxidoreductase, putative 0.0041 0.0177 0.1381
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0035 0.003
Onchocerca volvulus 0.0071 0.0361 0.0412
Mycobacterium tuberculosis Conserved protein 0.0199 0.1159 0.1861
Trypanosoma cruzi cruzipain precursor, putative 0.0128 0.0715 0.7457
Brugia malayi Papain family cysteine protease containing protein 0.0034 0.0131 0.0155
Mycobacterium leprae Probable polyketide synthase Pks1 0.0702 0.4281 0.706
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0702 0.4281 0.7051
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.013
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0177 0.0215
Mycobacterium ulcerans NADP-dependent alcohol dehydrogenase AdhC 0.0041 0.0177 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0035 0.0032
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0386 0.3922
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Mycobacterium ulcerans polyketide synthase Pks9 0.0437 0.2636 0.4317
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0125 0.0122
Leishmania major zinc binding dehydrogenase-like protein 0.0041 0.0177 0.1381
Toxoplasma gondii Zn-containing alcohol dehydrogenase 0.0041 0.0177 0.0336
Toxoplasma gondii cathepsin CPL 0.0034 0.0131 0.0225
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.061 0.0779
Echinococcus multilocularis protein dispatched 1 0.0054 0.0259 0.0257
Echinococcus granulosus ubiquitin specific protease 41 0.0075 0.0386 0.0765
Echinococcus multilocularis cysteine protease 0.0034 0.0131 0.0128
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0166 0.0952 0.1519
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.0174 0.0171
Onchocerca volvulus Cathepsin F homolog 0.0034 0.0131 0.0095
Trichomonas vaginalis importin beta-1, putative 0.0026 0.0086 0.0714
Brugia malayi RNA, U transporter 1 0.0092 0.0495 0.0629
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0039 0.0306
Echinococcus granulosus short transient receptor potential channel 6 0.0072 0.0371 0.0736
Trypanosoma brucei acyl transferase-like protein 0.0042 0.0182 0.1857
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0043 0.0231
Trichomonas vaginalis adenylate cyclase, putative 0.0016 0.002 0.0145
Mycobacterium tuberculosis Conserved hypothetical protein 0.0067 0.0337 0.0496
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0075 0.0386 0.075
Echinococcus granulosus dna polymerase eta 0.0019 0.0043 0.008
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0034 0.0131 0.0192
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0035 0.013
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0715 0.7457
Mycobacterium ulcerans NADP-dependent oxidoreductase 0.0041 0.0177 0.023
Entamoeba histolytica cysteine protease, putative 0.0034 0.0131 0.1738
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0089 0.0101
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0027 0.0024
Trypanosoma cruzi cysteine peptidase, putative 0.0128 0.0715 0.7457
Echinococcus granulosus NADH dehydrogenase 0.0067 0.0337 0.0668
Mycobacterium tuberculosis Possible quinone oxidoreductase (NADPH:quinone oxidoreductase) (zeta-crystallin) 0.0041 0.0177 0.023
Leishmania major d-xylulose reductase, putative 0.0041 0.0177 0.1381
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0131 0.1101
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0034 0.0131 0.0192
Loa Loa (eye worm) hypothetical protein 0.111 0.6815 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0075 0.0386 0.0765
Mycobacterium ulcerans acyl carrier protein 0.0067 0.0337 0.0496
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0145
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0033 0.006
Schistosoma mansoni cpg binding protein 0.0061 0.03 0.0578
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0043 0.004
Brugia malayi isocitrate dehydrogenase 0.0033 0.0125 0.0147
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.145 0.2128
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0125 0.0243
Loa Loa (eye worm) hypothetical protein 0.0186 0.1079 0.1583
Schistosoma mansoni cpg binding protein 0.0057 0.028 0.0537
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0071 0.0543
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0182 0.0341
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0043 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0017 0.003 0.0254
Loa Loa (eye worm) Smad1 0.0017 0.0027 0.0039
Mycobacterium ulcerans fatty acid synthase Fas 0.0208 0.1211 0.1949
Leishmania major protein kinase, putative 0.002 0.0045 0.0219
Mycobacterium leprae PROBABLE NADP-DEPENDENT ALCOHOL DEHYDROGENASE ADHC 0.0041 0.0177 0.026
Schistosoma mansoni DNA polymerase eta 0.0019 0.0043 0.0064
Mycobacterium ulcerans thioesterase TesA 0.0551 0.3342 0.549
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0071 0.0084
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0125 0.0227
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.028 0.041
Echinococcus granulosus Niemann Pick C1 protein 0.0158 0.0906 0.1804
Leishmania major oxidoreductase, putative 0.0041 0.0177 0.1381
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0166 0.0952 0.1398
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0011 0.0016
Onchocerca volvulus 0.0034 0.0131 0.0095
Schistosoma mansoni hypothetical protein 0.0346 0.2073 0.4128
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Brugia malayi N-terminal motif family protein 0.0186 0.1079 0.1388
Mycobacterium ulcerans Type I modular polyketide synthase 0.0661 0.4026 0.6627
Echinococcus granulosus transient receptor potential ion channel A 0.0106 0.0578 0.1149
Brugia malayi Transient-receptor-potential like protein 0.0041 0.0175 0.0212
Loa Loa (eye worm) hypothetical protein 0.0016 0.002 0.003
Echinococcus multilocularis Smad4 0.0017 0.0027 0.0024
Mycobacterium ulcerans polyketide synthase MbtC 0.0166 0.0952 0.1519
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0202 0.1863
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0039 0.0034
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0376 0.2255 0.3684
Leishmania major nuclear receptor binding factor-like protein 0.0041 0.0177 0.1381
Plasmodium vivax acyl carrier protein, putative 0.0067 0.0337 0.333
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0035 0.0064
Brugia malayi Cathepsin L-like cysteine proteinase 0.0022 0.0062 0.0065
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0161 0.0925 0.1473
Brugia malayi hypothetical protein 0.0052 0.0248 0.0307
Onchocerca volvulus 0.0034 0.0131 0.0095
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0386 0.4015
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0043 0.0395
Echinococcus granulosus histone acetyltransferase KAT2B 0.0149 0.0845 0.1683
Giardia lamblia Methyltransferase like 2 0.0199 0.1159 1
Entamoeba histolytica cysteine proteinase, putative 0.0022 0.0062 0.0553
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0081
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0075 0.0386 0.3212
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0166 0.0952 1
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0267 0.1582 0.2565
Mycobacterium ulcerans dehydrogenase 0.0041 0.0177 0.023
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0067 0.0337 0.0496
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Mycobacterium tuberculosis Possible dehydrogenase 0.0041 0.0177 0.023
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0034 0.0131 0.0128
Plasmodium vivax importin-beta 2, putative 0.0032 0.0124 0.1021
Mycobacterium tuberculosis Probable alcohol dehydrogenase AdhA 0.0041 0.0177 0.023
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0025 0.0077 0.0085
Brugia malayi MH2 domain containing protein 0.0246 0.145 0.1871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni importin beta-1 0.0032 0.0124 0.0226
Echinococcus multilocularis lamin dm0 0.0027 0.0089 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0089 0.0131
Echinococcus multilocularis G protein coupled receptor 139 0.0245 0.1442 0.144
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.0242 0.0355
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0075 0.0386 0.3311
Onchocerca volvulus Acyl carrier protein, mitochondrial homolog 0.0067 0.0337 0.0379
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0026 0.0086 0.0714
Echinococcus multilocularis short transient receptor potential channel 6 0.0072 0.0371 0.0368
Mycobacterium ulcerans short-chain dehydrogenase 0.0045 0.0201 0.027
Trichomonas vaginalis conserved hypothetical protein 0.0075 0.0386 0.3311
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.068 0.1338
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0035 0.009
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0016 0.002 0.0145
Mycobacterium ulcerans acyl-CoA synthetase 0.0067 0.0337 0.0496
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0034 0.0131 0.1101
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0016 0.002 0.0145
Schistosoma mansoni cathepsin F (C01 family) 0.0022 0.0062 0.0101
Echinococcus granulosus smad 0.0017 0.0027 0.0047
Schistosoma mansoni cpg binding protein 0.0061 0.03 0.0578
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Wolbachia endosymbiont of Brugia malayi NADPH:quinone reductase 0.0041 0.0177 0.1517
Mycobacterium ulcerans zinc-containing alcohol dehydrogenase NAD-dependent AdhB 0.0041 0.0177 0.023
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0077
Leishmania major cathepsin L-like protease 0.0128 0.0715 0.6106
Loa Loa (eye worm) phosphopantetheine attachment site family protein 0.0067 0.0337 0.0495
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0075 0.0386 0.3922
Echinococcus multilocularis cathepsin L 0.0017 0.003 0.0027
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0043 0.0007
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0337 0.0496
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.0242 0.03
Trypanosoma cruzi NADP-dependent alcohol hydrogenase, putative 0.0041 0.0177 0.1686
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0218 0.0429
Echinococcus granulosus lamin 0.0027 0.0089 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Loa Loa (eye worm) follicle stimulating hormone receptor 0.024 0.141 0.2069
Toxoplasma gondii HEAT repeat-containing protein 0.0032 0.0124 0.021
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0017 0.003 0.0037
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.1253 0.77 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.0242 0.0462
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0067 0.0337 0.0496
Toxoplasma gondii exonuclease III APE 0.0019 0.0039 0.0009
Trichomonas vaginalis rotamase, putative 0.0032 0.0124 0.1045
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0035 0.0161
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0043 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0152 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Entamoeba histolytica NADP-dependent alcohol dehydrogenase 0.0041 0.0177 0.2543
Loa Loa (eye worm) hypothetical protein 0.0041 0.0177 0.026
Echinococcus multilocularis dnaJ subfamily B 0.0819 0.5006 0.5004
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0041 0.0177 0.0215
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0125 0.1029
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0041 0.0177 0.1506
Loa Loa (eye worm) fatty acid synthase 0.0652 0.3971 0.5827
Entamoeba histolytica hypothetical protein 0.0026 0.0086 0.0967
Schistosoma mansoni hypothetical protein 0.0524 0.3176 0.6337
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0032 0.0026
Brugia malayi hypothetical protein 0.0037 0.015 0.018
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0037 0.0152 0.0182
Loa Loa (eye worm) hypothetical protein 0.0101 0.0552 0.081
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0218 0.1855
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0125 0.1257
Echinococcus granulosus dnaJ subfamily B 0.0819 0.5006 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0034 0.0131 0.1185
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0067 0.0337 0.0496
Mycobacterium tuberculosis Possible oxidoreductase FadB5 0.0041 0.0177 0.023
Mycobacterium ulcerans Type I modular polyketide synthase 0.0661 0.4026 0.6627
Trypanosoma cruzi oxidoreductase, putative 0.0041 0.0177 0.1686
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.0242 0.0478
Loa Loa (eye worm) hypothetical protein 0.0048 0.0218 0.032
Echinococcus granulosus intermediate filament protein 0.0027 0.0089 0.0172
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0129 0.0152
Mycobacterium leprae Polyketide synthase Pks13 0.0988 0.6055 1
Echinococcus granulosus expressed protein 0.0033 0.0129 0.0252
Toxoplasma gondii quinone oxidoreductase, putative 0.0041 0.0177 0.0336
Mycobacterium leprae Probable fatty-acid-CoA ligase FadD9 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0067 0.0337 0.0525
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Schistosoma mansoni single-minded 0.0016 0.002 0.0018
Onchocerca volvulus 0.0034 0.0131 0.0095
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0067 0.0337 0.0496
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0034 0.0131 0.1093
Mycobacterium ulcerans zinc-dependent alcohol dehydrogenase 0.0041 0.0177 0.023
Giardia lamblia DINP protein human, muc B family 0.0019 0.0043 0.0073
Mycobacterium ulcerans polyketide synthase 0.0702 0.4281 0.7051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0166 0.0952 0.1884
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0035 0.0309
Brugia malayi Cathepsin L-like precursor 0.0022 0.0062 0.0065
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0346 0.2073 0.3042
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0043 0.0395
Plasmodium vivax hypothetical protein, conserved 0.0099 0.0535 0.5471
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0071 0.0319
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0035 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Loa Loa (eye worm) hypothetical protein 0.0022 0.0062 0.0091
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0661 0.4026 0.6637
Trypanosoma cruzi nuclear receptor binding factor, putative 0.0041 0.0177 0.1686
Toxoplasma gondii type I fatty acid synthase, putative 0.047 0.2843 0.6615
Loa Loa (eye worm) hypothetical protein 0.0101 0.0552 0.081
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0702 0.4281 0.7051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0067 0.0337 0.0423
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0166 0.0952 0.095
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0125 0.1257
Schistosoma mansoni ap endonuclease 0.0019 0.0039 0.0055
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0043 0.0246
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0124 0.1114
Brugia malayi Cathepsin L-like precursor 0.0034 0.0131 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0027 0.0047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma brucei unspecified product 0.0019 0.0043 0.0395
Mycobacterium ulcerans polyketide synthase Pks13 0.0988 0.6055 1
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0117 0.0647 0.6719
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0039 0.0349
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0035 0.0309
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0067 0.0337 0.0496
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.145 0.2128
Schistosoma mansoni patched 1 0.0048 0.0218 0.0413
Echinococcus multilocularis AMP dependent ligase 0.0067 0.0337 0.0334
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0035 0.0158
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0125 0.0122
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0043 0.0395
Loa Loa (eye worm) hypothetical protein 0.0111 0.061 0.0896
Echinococcus granulosus dna polymerase kappa 0.0019 0.0043 0.008
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0035 0.0064
Trypanosoma cruzi Acyl carrier protein, mitochondrial, putative 0.0067 0.0337 0.3398
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0661 0.4026 0.6637
Loa Loa (eye worm) hypothetical protein 0.0058 0.0284 0.0417
Onchocerca volvulus 0.0052 0.0248 0.0256
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0027 0.0031
Echinococcus multilocularis cathepsin L cysteine protease 0.0034 0.0131 0.0128
Mycobacterium ulcerans polyketide synthase MbtD 0.0203 0.1184 0.1904
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0034 0.0131 0.1101
Toxoplasma gondii FATC domain-containing protein 0.0025 0.0077 0.0099
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0011 0.0016
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Schistosoma mansoni smad1 5 8 and 0.0017 0.0027 0.0031
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Mycobacterium tuberculosis Probable oxidoreductase 0.0041 0.0177 0.023
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0661 0.4026 0.5221
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0125 0.1121
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Echinococcus granulosus expressed conserved protein 0.0104 0.0569 0.1131
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Echinococcus granulosus acyl carrier protein mitochondrial 0.0067 0.0337 0.0668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0025 0.0077 0.0753
Mycobacterium leprae Probable oxidireductase 0.0041 0.0177 0.026
Schistosoma mansoni hypothetical protein 0.0819 0.5006 1
Onchocerca volvulus 0.0034 0.0131 0.0095
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0067 0.0337 0.0496
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0661 0.4026 0.6627
Entamoeba histolytica Ran family GTPase 0.0024 0.0071 0.0707
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0125 0.0211
Entamoeba histolytica cysteine proteinase, putative 0.0034 0.0131 0.1738
Echinococcus multilocularis geminin 0.0524 0.3176 0.3174
Loa Loa (eye worm) alcohol dehydrogenase class III 0.0041 0.0177 0.026
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0166 0.0952 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0035 0.0048
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0012 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.022
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0075 0.0386 0.3123
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0112 0.0621 0.1221
Trypanosoma cruzi cysteine protease, putative 0.0017 0.003 0.0102
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0034 0.0131 0.1101
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0128 0.0715 0.7496
Schistosoma mansoni [ACP] S-malonyltransferase 0.0042 0.0182 0.0341
Leishmania major cathepsin L-like protease 0.0034 0.0131 0.097
Brugia malayi Methyltransferase-like protein 4 0.0199 0.1159 0.1492
Mycobacterium ulcerans NADPH quinone oxidoreductase FadB4 0.0041 0.0177 0.023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0218 0.032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Echinococcus multilocularis musashi 0.0027 0.0089 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0035 0.0273
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0178 0.2561
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0043 0.0395
Schistosoma mansoni hypothetical protein 0.0046 0.0207 0.0392
Echinococcus granulosus cysteine protease 0.0017 0.003 0.0054
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0166 0.0952 0.1223

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 7.3048 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.081 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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