Detailed information for compound 157691

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.599 | Formula: C28H30O6S
  • H donors: 2 H acceptors: 5 LogP: 6.44 Rotable bonds: 14
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CCc1cc(ccc1OCCCCCCc1ccccc1)[S+](c1cccc(c1)C(=O)O)[O-]
  • InChi: 1S/C28H30O6S/c29-27(30)17-14-22-19-25(35(33)24-13-8-12-23(20-24)28(31)32)15-16-26(22)34-18-7-2-1-4-9-21-10-5-3-6-11-21/h3,5-6,8,10-13,15-16,19-20H,1-2,4,7,9,14,17-18H2,(H,29,30)(H,31,32)
  • InChiKey: XCOVZQPICWLJQU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0055 0.0027 0.0026
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0391 0.0407 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Echinococcus multilocularis NAD dependent deacetylase sirtuin 3 0.0731 0.0792 0.0989
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.1771 0.1967 0.3223
Plasmodium falciparum plasmepsin VII 0.0037 0.0007 0.0126
Onchocerca volvulus 0.0052 0.0024 0.0339
Mycobacterium ulcerans polyketide synthase 0.0078 0.0053 0.0804
Echinococcus granulosus expressed protein 0.0372 0.0385 0.0385
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0407 0.0667
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Mycobacterium ulcerans polyketide synthase 0.0083 0.0059 0.0952
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Brugia malayi Protein arginine N-methyltransferase 0.0112 0.0092 0.0092
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0391 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Toxoplasma gondii rhoptry neck protein RON9 0.0038 0.0008 0.018
Echinococcus multilocularis 0.0119 0.01 0.0124
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0078 0.0054 0.5
Onchocerca volvulus 0.0637 0.0685 1
Plasmodium vivax LCCL domain-containing protein 0.0047 0.0018 0.0383
Loa Loa (eye worm) hypothetical protein 0.0312 0.0318 0.0318
Loa Loa (eye worm) endoprotease bli-4 0.8874 1 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Leishmania major arginine N-methyltransferase-like protein 0.0199 0.019 0.2395
Schistosoma mansoni integrin beta subunit 0.0751 0.0814 0.0813
Schistosoma mansoni c4b-binding protein beta chain 0.0038 0.0008 0.0008
Toxoplasma gondii type I fatty acid synthase, putative 0.0083 0.0059 0.1421
Loa Loa (eye worm) lectin C-type domain-containing protein 0.0032 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Echinococcus granulosus adam 0.0087 0.0063 0.0063
Brugia malayi Kringle domain containing protein 0.0052 0.0024 0.0024
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0112 0.0092 0.0091
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0112 0.0092 0.015
Schistosoma mansoni hypothetical protein 0.0047 0.0018 0.0017
Loa Loa (eye worm) TK/EGFR protein kinase 0.0623 0.0669 0.0669
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0051 0.0022 0.0116
Plasmodium falciparum subtilisin-like protease 3 0.0391 0.0407 0.9408
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0017 0.0017
Onchocerca volvulus 0.0038 0.0008 0.0114
Brugia malayi protein kinase C II. 0.0095 0.0072 0.0072
Echinococcus granulosus lysine specific histone demethylase 1A 0.0587 0.0629 0.0628
Echinococcus multilocularis NAD dependent deacetylase sirtuin 1 0.0108 0.0087 0.0108
Schistosoma mansoni discoidin domain receptor 0.0047 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Plasmodium vivax plasmepsin IV, putative 0.0037 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0041 0.0012 0.0012
Loa Loa (eye worm) TK/ALK protein kinase 0.0077 0.0052 0.0052
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0037 0.0007 0.0007
Plasmodium falciparum transcriptional regulatory protein sir2b 0.0108 0.0087 0.1988
Loa Loa (eye worm) hypothetical protein 0.0637 0.0685 0.0685
Mycobacterium tuberculosis Possible arabinofuranosyltransferase AftD 0.0047 0.0018 0.0388
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0076 0.005 0.1195
Echinococcus multilocularis protein arginine N methyltransferase 8 0.0199 0.019 0.0237
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0053 0.0804
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0044 0.0014 0.0014
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0078 0.0053 0.0053
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0199 0.019 0.0311
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0053 0.1264
Toxoplasma gondii aspartyl protease ASP1 0.0037 0.0007 0.0134
Echinococcus multilocularis C type lectin domian containing protein 0.0038 0.0008 0.001
Giardia lamblia Sirtuin type 2 0.0108 0.0087 0.0181
Mycobacterium ulcerans thioesterase 0.0067 0.0041 0.0492
Brugia malayi celfurPC protein 0.7103 0.7998 0.7998
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0226 0.022 0.022
Mycobacterium leprae Possible secreted protease 0.0391 0.0407 1
Plasmodium falciparum plasmepsin I 0.0037 0.0007 0.0126
Echinococcus multilocularis neuroendocrine convertase 2 0.5609 0.6307 0.7886
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0224 0.0218 0.0272
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0078 0.0053 0.0911
Loa Loa (eye worm) acyl carrier protein 0.0037 0.0007 0.0007
Loa Loa (eye worm) WD40 repeat protein 0.0209 0.0201 0.0201
Brugia malayi zinc metalloproteinase toh-2 precursor 0.0032 0.0001 0.0001
Echinococcus multilocularis integrin beta 2 0.0948 0.1036 0.1295
Entamoeba histolytica arginine N-methyltransferase protein, putative 0.0312 0.0318 0.4002
Entamoeba histolytica hypothetical protein 0.005 0.0021 0.0253
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0391 0.0407 1
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0041 0.023
Loa Loa (eye worm) hypothetical protein 0.0108 0.0087 0.0087
Toxoplasma gondii histone lysine-specific demethylase 0.0119 0.01 0.243
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0312 0.0318 0.4002
Loa Loa (eye worm) sex muscle abnormal protein 5 0.014 0.0124 0.0124
Plasmodium falciparum LCCL domain-containing protein 0.0047 0.0018 0.0383
Plasmodium falciparum plasmepsin VIII, putative 0.0037 0.0007 0.0126
Loa Loa (eye worm) transcriptional regulator 0.0731 0.0792 0.0792
Loa Loa (eye worm) DPY-31 protein 0.0032 0.0001 0.0001
Schistosoma mansoni site-1 peptidase (S08 family) 0.0391 0.0407 0.0407
Loa Loa (eye worm) hypothetical protein 0.0197 0.0187 0.0187
Trypanosoma brucei Silent information regulator 2 related protein 3 0.0108 0.0087 0.1086
Onchocerca volvulus 0.0038 0.0008 0.0114
Schistosoma mansoni glutamate receptor NMDA 0.0258 0.0256 0.0256
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Plasmodium falciparum plasmepsin V 0.0414 0.0433 1
Loa Loa (eye worm) CUB domain-containing protein 0.0032 0.0001 0.0001
Onchocerca volvulus 0.0171 0.0158 0.2305
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0078 0.0054 0.0815
Entamoeba histolytica protein kinase, putative 0.0033 0.0003 0.002
Trypanosoma cruzi glutathionylspermidine synthase, putative 0.0352 0.0363 0.4418
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0228 0.0223 0.0223
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0112 0.0092 0.2237
Brugia malayi astacin protease protein 30 0.0032 0.0001 0.0001
Schistosoma mansoni apoptosis regulator bax 0.0055 0.0027 0.0026
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055 0.0027 0.0027
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Plasmodium falciparum cysteine repeat modular protein 1 0.0052 0.0024 0.0525
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0407 0.0667
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0052 0.0024 0.057
Loa Loa (eye worm) hypothetical protein 0.012 0.0101 0.0101
Brugia malayi amine oxidase, flavin-containing family protein 0.0169 0.0156 0.0156
Mycobacterium leprae Probable polyketide synthase Pks1 0.0083 0.0059 0.1057
Echinococcus multilocularis discoidin domain containing receptor 2 0.0047 0.0018 0.0021
Entamoeba histolytica SWIRM domain protein 0.005 0.0021 0.0253
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0391 0.0407 1
Echinococcus multilocularis adam 0.0087 0.0063 0.0078
Schistosoma mansoni hypothetical protein 0.0112 0.0092 0.0091
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Schistosoma mansoni tyrosine kinase 0.0623 0.0669 0.0668
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0119 0.01 0.2015
Echinococcus granulosus discoidin domain receptor 0.0047 0.0018 0.0017
Onchocerca volvulus Putative cubilin 0.0041 0.0012 0.0164
Schistosoma mansoni protein kinase 0.0258 0.0256 0.0256
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.3447 0.3863 0.3863
Brugia malayi aspartic protease BmAsp-1, identical 0.0037 0.0007 0.0007
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0076 0.005 0.005
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.8874 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0312 0.0318 0.3825
Brugia malayi Carm1-pending protein 0.0112 0.0092 0.0092
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5427 0.6102 1
Mycobacterium ulcerans oxidoreductase 0.0119 0.01 0.2015
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055 0.0027 0.0033
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2162 0.241 0.3948
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0199 0.019 0.0311
Toxoplasma gondii SWIRM domain-containing protein 0.005 0.0021 0.0492
Mycobacterium ulcerans polyketide synthase Pks13 0.0118 0.0098 0.1978
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0083 0.0059 0.0952
Loa Loa (eye worm) CUB domain-containing protein 0.0032 0.0001 0.0001
Mycobacterium ulcerans dehydrogenase 0.0119 0.01 0.2015
Brugia malayi hypothetical protein 0.0119 0.01 0.01
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0095 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.002 0.002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Plasmodium falciparum plasmepsin VI 0.0037 0.0007 0.0126
Schistosoma mansoni site-1 peptidase (S08 family) 0.0391 0.0407 0.0407
Echinococcus granulosus epidermal growth factor receptor 0.0623 0.0669 0.0668
Loa Loa (eye worm) reprolysin 0.0044 0.0014 0.0014
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0391 0.0407 0.0407
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.0011 0.0248
Brugia malayi Nematode astacin protease protein 30 0.0032 0.0001 0.0001
Brugia malayi Cam kinase protein 1 0.0032 0.0001 0.0001
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0053 0.0804
Leishmania major trypanothione synthetase, putative 0.0068 0.0041 0.0511
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0007 0.0126
Loa Loa (eye worm) hypothetical protein 0.0077 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0058 0.0031 0.0708
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Echinococcus multilocularis protein kinase c epsilon type 0.0095 0.0072 0.009
Echinococcus granulosus protein arginine N methyltransferase 8 0.0199 0.019 0.019
Echinococcus granulosus methyltransferase protein 5 0.0112 0.0092 0.0091
Schistosoma mansoni btb and poz domain-containing protein 0.0047 0.0018 0.0017
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0258 0.0256 0.0256
Toxoplasma gondii subtilisin SUB1 0.0391 0.0407 1
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Echinococcus multilocularis NAD dependent deacetylase sirtuin 6 0.0108 0.0087 0.0108
Entamoeba histolytica PH domain containing protein kinase, putative 0.0078 0.0053 0.0654
Brugia malayi hypothetical protein 0.0077 0.0052 0.0052
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0001 0.0001
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2162 0.241 0.3948
Loa Loa (eye worm) proprotein convertase 2 0.2162 0.241 0.241
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0112 0.0092 0.1149
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Plasmodium falciparum apical sushi protein 0.0038 0.0008 0.0169
Loa Loa (eye worm) hypothetical protein 0.0119 0.01 0.01
Toxoplasma gondii type I fatty acid synthase, putative 0.0058 0.003 0.0712
Brugia malayi hypothetical protein 0.0312 0.0318 0.0318
Toxoplasma gondii aspartyl protease ASP3 0.0037 0.0007 0.0134
Echinococcus granulosus protein arginine N methyltransferase 7 0.0112 0.0092 0.0091
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0112 0.0092 0.1149
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0062 0.0035 0.034
Onchocerca volvulus 0.0038 0.0008 0.0114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Loa Loa (eye worm) hypothetical protein 0.0119 0.01 0.01
Plasmodium vivax aspartyl protease, putative 0.0037 0.0007 0.0126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.0792 0.0791
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.5427 0.6102 1
Plasmodium vivax apical sushi protein, putative 0.0038 0.0008 0.0169
Echinococcus granulosus NAD dependent deacetylase sirtuin 7 0.0108 0.0087 0.0086
Schistosoma mansoni hypothetical protein 0.0077 0.0052 0.0051
Echinococcus multilocularis chromatin regulatory protein sir2 0.0731 0.0792 0.0989
Onchocerca volvulus 0.0038 0.0008 0.0114
Brugia malayi Sushi domain 0.0038 0.0008 0.0008
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0391 0.0407 0.0407
Brugia malayi Protein kinase domain containing protein 0.0077 0.0052 0.0052
Schistosoma mansoni amine oxidase 0.0119 0.01 0.0099
Trypanosoma brucei trypanothione synthetase 0.0068 0.0041 0.0511
Schistosoma mansoni furin-1 (S08 family) 0.3838 0.4305 0.4305
Loa Loa (eye worm) subtilase 0.0391 0.0407 0.0407
Onchocerca volvulus 0.0076 0.005 0.0728
Toxoplasma gondii F5/8 type C domain-containing protein 0.0047 0.0018 0.0408
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0241 0.0237 0.0236
Loa Loa (eye worm) TK/ROR protein kinase 0.0052 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0118 0.0098 0.2379
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0078 0.0053 0.1264
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Echinococcus multilocularis nuclear receptor 2C2 associated protein 0.0047 0.0018 0.0021
Entamoeba histolytica arginine N-methyltransferase 1, putative 0.0112 0.0092 0.1149
Schistosoma mansoni growth factor receptor-bound protein 0.014 0.0124 0.0123
Trypanosoma cruzi trypanothione synthetase 0.0068 0.0041 0.023
Mycobacterium tuberculosis Conserved hypothetical protein 0.0119 0.01 0.2414
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0083 0.0059 0.1057
Brugia malayi pregnancy-associated plasma protein-A 0.0038 0.0008 0.0008
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.5427 0.6102 0.763
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0199 0.019 0.0311
Onchocerca volvulus 0.0047 0.0018 0.0249
Plasmodium vivax hypothetical protein, conserved 0.0108 0.0087 0.1988
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0055 0.0028 0.0027
Toxoplasma gondii histone deacetylase SIR2-like 0.0108 0.0087 0.2113
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2162 0.241 0.3948
Brugia malayi neuroendocrine convertase 1 precursor 0.5609 0.6307 0.6307
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Echinococcus granulosus NAD dependent deacetylase sirtuin 3 0.0731 0.0792 0.0791
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Echinococcus multilocularis discoidin domain containing receptor 2 0.0047 0.0018 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Onchocerca volvulus 0.0077 0.0052 0.0749
Toxoplasma gondii F5/8 type C domain-containing protein 0.0047 0.0018 0.0408
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Plasmodium falciparum plasmepsin IV 0.0037 0.0007 0.0126
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0057 0.0029 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Brugia malayi Calcium binding EGF domain containing protein 0.0041 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0052 0.0024 0.0024
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0062 0.0035 0.034
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0087 0.0086
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.1771 0.1967 0.3223
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0046 0.0017 0.0017
Mycobacterium ulcerans monoamine oxidase 0.0119 0.01 0.2015
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0423 0.0443 0.5589
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Echinococcus granulosus NAD dependent deacetylase sirtuin 6 0.0108 0.0087 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0407 0.0667
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055 0.0027 0.0026
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0226 0.022 0.022
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0021 0.0034
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Schistosoma mansoni growth factor receptor-bound protein 0.014 0.0124 0.0123
Plasmodium vivax subtilisin-like protease 1 0.0391 0.0407 0.9408
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0063 0.0036 0.0853
Onchocerca volvulus 0.0037 0.0007 0.0087
Loa Loa (eye worm) hypothetical protein 0.0077 0.0052 0.0052
Toxoplasma gondii subtilisin SUB6 0.0391 0.0407 1
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0391 0.0407 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0391 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Brugia malayi AMP-binding enzyme family protein 0.0076 0.005 0.005
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Toxoplasma gondii kringle domain-containing protein 0.0052 0.0024 0.0558
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Onchocerca volvulus 0.0053 0.0025 0.036
Trypanosoma brucei subtilisin peptidase 0.0391 0.0407 0.5138
Loa Loa (eye worm) hypothetical protein 0.0391 0.0407 0.0407
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0391 0.0407 0.0407
Chlamydia trachomatis protoporphyrinogen oxidase 0.0119 0.01 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0119 0.01 0.2286
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0017 0.0021
Brugia malayi aspartic protease BmAsp-2, identical 0.0037 0.0007 0.0007
Echinococcus granulosus fibrillin 1 0.0032 0.0001 0.0001
Plasmodium vivax aspartyl protease, putative 0.0037 0.0007 0.0126
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0059 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0018
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0112 0.0092 0.015
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0199 0.019 0.019
Leishmania major NAD dependent deacetylase, putative,transcriptional regulator, Sir2 family protein, nicotinic acid mononucleotide 5,6-dimethylbe 0.0108 0.0087 0.1086
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Brugia malayi Kelch motif family protein 0.0228 0.0223 0.0223
Brugia malayi transcriptional regulator, Sir2 family protein 0.0731 0.0792 0.0792
Leishmania major sir2-family protein-like protein 0.0108 0.0087 0.1086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Toxoplasma gondii histone arginine methyltransferase PRMT1 0.0199 0.019 0.4662
Echinococcus multilocularis Coagulation factor 5 8 type, C terminal 0.0047 0.0018 0.0021
Plasmodium falciparum subtilisin-like protease 2 0.0391 0.0407 0.9408
Trypanosoma cruzi subtilisin peptidase 0.0391 0.0407 0.4995
Echinococcus granulosus chromatin regulatory protein sir2 0.0731 0.0792 0.0791
Echinococcus multilocularis protein will die slowly 0.0209 0.0201 0.025
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0199 0.019 0.019
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0112 0.0092 0.0888
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0007 0.0006
Echinococcus multilocularis tissue type plasminogen activator 0.0052 0.0024 0.0029
Loa Loa (eye worm) hypothetical protein 0.0077 0.0052 0.0052
Toxoplasma gondii F5/8 type C domain-containing protein 0.0047 0.0018 0.0408
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0118 0.0098 0.2379
Brugia malayi Sex muscle abnormal protein 5 0.014 0.0124 0.0124
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0078 0.0053 0.0804
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0112 0.0092 0.0888
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0109 0.0088 0.0109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0078 0.0054 0.5
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Toxoplasma gondii histone deacetylase SIR2 0.0108 0.0087 0.2113
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0017 0.0021
Echinococcus granulosus nmda type glutamate receptor 0.0109 0.0088 0.0088
Plasmodium falciparum subtilisin-like protease 1 0.0391 0.0407 0.9408
Echinococcus granulosus protein arginine methyltransferase 0.0199 0.019 0.019
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0014 0.0014
Brugia malayi Subtilase family protein 0.0391 0.0407 0.0407
Schistosoma mansoni hypothetical protein 0.0077 0.0052 0.0051
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0037 0.0007 0.0007
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0112 0.0092 0.0092
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0037 0.0007 0.001
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Plasmodium vivax NAD-dependent deacetylase, putative 0.0108 0.0087 0.1988
Loa Loa (eye worm) hypothetical protein 0.0587 0.0629 0.0629
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.2162 0.241 0.2409
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0112 0.0092 0.0114
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0087 0.0086
Brugia malayi hypothetical protein 0.0032 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0035 0.0005 0.0005
Onchocerca volvulus 0.0141 0.0124 0.1805
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Echinococcus multilocularis discoidin domain containing receptor 2 0.0047 0.0018 0.0021
Onchocerca volvulus 0.0038 0.0008 0.0114
Loa Loa (eye worm) hypothetical protein 0.0044 0.0014 0.0014
Schistosoma mansoni hypothetical protein 0.1771 0.1967 0.1967
Trichomonas vaginalis conserved hypothetical protein 0.005 0.0021 0.0034
Echinococcus granulosus tissue type plasminogen activator 0.0052 0.0024 0.0023
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0119 0.01 0.2286
Schistosoma mansoni serine/threonine protein kinase 0.0224 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.8874 1 1
Mycobacterium ulcerans Sir2-like regulatory protein 0.0108 0.0087 0.1681
Echinococcus granulosus C type lectin domian containing protein 0.0038 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Brugia malayi Zinc metalloproteinase toh-2 precursor 0.0032 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Echinococcus multilocularis serine:threonine protein kinase N2 0.0087 0.0063 0.0078
Entamoeba histolytica hypothetical protein 0.0312 0.0318 0.4002
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0112 0.0092 0.0114
Loa Loa (eye worm) pregnancy-associated plasma protein-E 0.0038 0.0008 0.0008
Brugia malayi CUB domain containing protein 0.0032 0.0001 0.0001
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0001 0.0001
Echinococcus granulosus Coagulation factor 5 8 type C terminal 0.0047 0.0018 0.0017
Plasmodium falciparum LCCL domain-containing protein 0.0047 0.0018 0.0383
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0001 0.0001
Plasmodium vivax aspartyl protease, putative 0.0037 0.0007 0.0126
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0032 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.0055 0.0027 0.0026
Leishmania major subtilisin-like serine peptidase 0.0391 0.0407 0.5138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Echinococcus multilocularis Furin 1 0.2162 0.241 0.3012
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0078 0.0054 0.1274
Onchocerca volvulus Fatty acid synthase homolog 0.0146 0.013 0.1888
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0684 0.0738 0.0738
Brugia malayi Probable ATP-dependent helicase DHX35 0.0032 0.0001 0.0001
Toxoplasma gondii histone arginine methyltransferase PRMT3 0.0112 0.0092 0.2237
Echinococcus granulosus glutamate receptor 2 0.0046 0.0017 0.0017
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0391 0.0407 0.0407
Loa Loa (eye worm) sirtuin 4 0.0108 0.0087 0.0087
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2162 0.241 0.3948
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0037 0.0007 0.0134
Schistosoma mansoni protein kinase 0.0258 0.0256 0.0256
Onchocerca volvulus 0.0038 0.0008 0.0114
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0731 0.0792 0.1297
Toxoplasma gondii rhoptry neck protein RON1 0.0038 0.0008 0.018
Loa Loa (eye worm) Carm1-pending protein 0.0112 0.0092 0.0092
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0001 0.0001
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0108 0.0087 0.1086
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0731 0.0792 1
Loa Loa (eye worm) zinc metalloproteinase toh-2 0.0032 0.0001 0.0001
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0078 0.0054 0.1274
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0083 0.0059 0.1057
Schistosoma mansoni SWI/SNF complex-related 0.005 0.0021 0.002
Loa Loa (eye worm) DEAH box polypeptide 35 0.0032 0.0001 0.0001
Echinococcus granulosus protein kinase c epsilon type 0.0095 0.0072 0.0072
Toxoplasma gondii subtilisin SUB12 0.0391 0.0407 1
Brugia malayi Will die slowly protein 0.0209 0.0201 0.0201
Toxoplasma gondii subtilisin SUB10 0.0391 0.0407 1
Plasmodium vivax plasmepsin V, putative 0.0414 0.0433 1
Echinococcus multilocularis MAM 0.0077 0.0052 0.0064
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0108 0.0087 0.0822
Brugia malayi hypothetical protein 0.0057 0.0029 0.0029
Echinococcus granulosus protein will die slowly 0.0209 0.0201 0.02
Loa Loa (eye worm) hypothetical protein 0.0038 0.0008 0.0008
Loa Loa (eye worm) apoptosis regulator protein 0.0055 0.0027 0.0027
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Brugia malayi Protein kinase domain containing protein 0.0052 0.0024 0.0024
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0044 0.0014 0.0014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Brugia malayi Eukaryotic aspartyl protease family protein 0.0037 0.0007 0.0007
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0037 0.0007 0.0007
Mycobacterium ulcerans thioesterase TesA 0.0067 0.0041 0.0492
Toxoplasma gondii subtilisin SUB9 0.0391 0.0407 1
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0423 0.0443 0.5459
Leishmania major arginine N-methyltransferase, type I 0.0112 0.0092 0.1149
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2162 0.241 0.3948
Plasmodium falciparum plasmepsin II 0.0037 0.0007 0.0126
Trichomonas vaginalis WD repeat domain, putative 0.0209 0.0201 0.0328
Toxoplasma gondii subtilisin SUB4 0.0391 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.0587 0.0629 0.0629
Brugia malayi SWIRM domain containing protein 0.005 0.0021 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0119 0.01 0.2286
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0391 0.0407 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Toxoplasma gondii aspartyl protease 0.0037 0.0007 0.0134
Schistosoma mansoni protein arginine N-methyltransferase 1 0.0199 0.019 0.019
Mycobacterium tuberculosis Probable thioesterase TesA 0.0067 0.0041 0.0967
Echinococcus granulosus NAD dependent deacetylase sirtuin 1 0.0108 0.0087 0.0086
Loa Loa (eye worm) fatty acid synthase 0.008 0.0055 0.0055
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0081 0.0056 0.0056
Brugia malayi GCC2 and GCC3 family protein 0.0048 0.002 0.002
Echinococcus multilocularis 0.7103 0.7998 1
Echinococcus granulosus growth factor receptor bound protein 2 0.014 0.0124 0.0123
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0044 0.0014 0.0017
Brugia malayi Pepsin A precursor 0.0037 0.0007 0.0007
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0587 0.0629 0.0785
Toxoplasma gondii subtilisin SUB7 0.0391 0.0407 1
Echinococcus multilocularis protoporphyrinogen oxidase 0.0119 0.01 0.0124
Mycobacterium ulcerans Type I modular polyketide synthase 0.0078 0.0053 0.0804
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0067 0.0041 0.0603
Giardia lamblia Hypothetical protein 0.0731 0.0792 0.2119
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Toxoplasma gondii aspartyl protease ASP5 0.0377 0.0391 0.9605
Entamoeba histolytica NAD-dependent deacetylase 1, putative 0.0108 0.0087 0.1086
Brugia malayi NAD-dependent deacetylase SIRT1 0.0108 0.0087 0.0087
Onchocerca volvulus 0.0038 0.0008 0.0114
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.015 0.0135 0.0135
Giardia lamblia Furin precursor putative serine protease 0.1771 0.1967 0.5352
Plasmodium vivax protein arginine N-methyltransferase 1, putative 0.0199 0.019 0.4386
Toxoplasma gondii PA14 domain-containing protein 0.0047 0.0018 0.0408
Echinococcus multilocularis fibrillin 1 0.0032 0.0001 0.0001
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0119 0.01 0.243
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.0731 0.0792 1
Echinococcus granulosus MAM 0.0077 0.0052 0.0051
Brugia malayi Suppressor of lurcher protein 1 precursor 0.0032 0.0001 0.0001
Plasmodium vivax LCCL domain-containing protein 0.0047 0.0018 0.0383
Trichomonas vaginalis protein arginine N-methyltransferase, putative 0.0112 0.0092 0.015
Echinococcus multilocularis protein arginine methyltransferase 0.0199 0.019 0.0237
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0078 0.0053 0.1264
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.5427 0.6102 0.6102
Schistosoma mansoni dock 0.0047 0.0018 0.0017
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0391 0.0407 1
Brugia malayi hypothetical protein 0.0038 0.0008 0.0008
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0037 0.0007 0.0006
Onchocerca volvulus 0.0077 0.0052 0.0749
Echinococcus granulosus discoidin domain containing receptor 2 0.0047 0.0018 0.0017
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0032 0.0001 0.0001
Plasmodium falciparum plasmepsin X 0.0037 0.0007 0.0126
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.005 0.0021 0.002
Echinococcus granulosus membrane bound transcription factor site 1 0.0391 0.0407 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Trypanosoma brucei Silent information regulator 2 related protein 1 0.0731 0.0792 1
Trypanosoma cruzi Silent information regulator 2 related protein 3 0.0108 0.0087 0.0822
Leishmania major hypothetical protein, conserved 0.0052 0.0024 0.0287
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Echinococcus granulosus serine:threonine protein kinase N2 0.0078 0.0053 0.0052
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0391 0.0407 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0001 0.0001
Plasmodium vivax subtilisin-like protease 2, putative 0.0391 0.0407 0.9408
Onchocerca volvulus 0.0037 0.0007 0.0087
Echinococcus granulosus Furin 1 0.2162 0.241 0.2409
Giardia lamblia NAD-dependent histone deacetylase Sir2 0.0108 0.0087 0.0181
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0691 0.0746 0.0746
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0423 0.0443 0.5459
Schistosoma mansoni memapsin-2 (A01 family) 0.0037 0.0007 0.0006
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0072 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0391 0.0407 0.4995
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0083 0.0059 0.1404
Schistosoma mansoni hypothetical protein 0.0052 0.0024 0.0023
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0119 0.01 0.2015
Echinococcus granulosus glutamate NMDA receptor subunit 0.0258 0.0256 0.0256
Toxoplasma gondii bicoid-interacting protein BIN3 0.0112 0.0092 0.2237
Schistosoma mansoni hypothetical protein 0.0055 0.0027 0.0026
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0119 0.01 0.2108
Giardia lamblia Transcriptional regulator, Sir2 family 0.0108 0.0087 0.0181
Entamoeba histolytica hypothetical protein, conserved 0.0108 0.0087 0.1086
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0037 0.0007 0.0134
Plasmodium falciparum plasmepsin IX 0.0037 0.0007 0.0126
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Mycobacterium ulcerans NAD-dependent deacetylase 0.0108 0.0087 0.1681
Toxoplasma gondii subtilisin SUB2 0.0391 0.0407 1
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0407 0.0667
Echinococcus granulosus integrin beta 2 0.0948 0.1036 0.1036
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1323 0.1461 0.146
Echinococcus granulosus neuroendocrine convertase 2 0.5609 0.6307 0.6307
Brugia malayi Nematode astacin protease protein 30 0.0032 0.0001 0.0001
Brugia malayi Lectin C-type domain containing protein 0.0032 0.0001 0.0001
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0059 0.0952
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0083 0.0059 0.1404
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0047 0.0018 0.0028
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0046 0.0017 0.037
Loa Loa (eye worm) hypothetical protein 0.0037 0.0007 0.0007
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0119 0.01 0.2286
Brugia malayi CUB domain containing protein 0.0032 0.0001 0.0001
Echinococcus multilocularis glutamate receptor 2 0.0046 0.0017 0.0021
Brugia malayi Furin-like cysteine rich region family protein 0.0623 0.0669 0.0669
Schistosoma mansoni glutamate receptor NMDA 0.0046 0.0017 0.0017
Brugia malayi hypothetical protein 0.0197 0.0187 0.0187
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0119 0.01 0.2015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Brugia malayi SWIRM domain containing protein 0.0637 0.0685 0.0685
Entamoeba histolytica SWIRM domain protein 0.005 0.0021 0.0253
Schistosoma mansoni septate junction protein 0.0057 0.0029 0.0028
Onchocerca volvulus 0.0038 0.0008 0.0114
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0052 0.0024 0.0525
Toxoplasma gondii subtilisin SUB5 0.0391 0.0407 1
Onchocerca volvulus 0.0038 0.0008 0.0114
Trichomonas vaginalis hypothetical protein 0.0047 0.0018 0.0028
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0046 0.0017 0.0021
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055 0.0027 0.0026
Brugia malayi Stress-activated protein kinase jnk-1 0.0224 0.0218 0.0218
Brugia malayi Angiotensin-converting enzyme family protein 0.0691 0.0746 0.0746
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0119 0.01 0.2286
Echinococcus granulosus discoidin domain containing receptor 2 0.0047 0.0018 0.0017
Trichomonas vaginalis conserved hypothetical protein 0.0391 0.0407 0.0667
Echinococcus granulosus discoidin domain containing receptor 2 0.0047 0.0018 0.0017
Echinococcus multilocularis c4b binding protein beta chain 0.0038 0.0008 0.001
Mycobacterium tuberculosis Transcriptional regulatory protein 0.0108 0.0087 0.2097
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0391 0.0407 0.0509
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Plasmodium vivax aspartyl proteinase, putative 0.0037 0.0007 0.0126
Brugia malayi CUB domain containing protein 0.0032 0.0001 0.0001
Leishmania major silent information regulator 2, putative 0.0731 0.0792 1
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Plasmodium falciparum protein arginine N-methyltransferase 1 0.0199 0.019 0.4386
Plasmodium falciparum transcriptional regulatory protein sir2a 0.0108 0.0087 0.1988
Loa Loa (eye worm) integrin beta-2 0.1283 0.1416 0.1416
Brugia malayi proprotein convertase 2 0.5609 0.6307 0.6307
Echinococcus granulosus furin 0.8874 1 1
Onchocerca volvulus 0.0047 0.0018 0.0249
Brugia malayi Integrin beta pat-3 precursor 0.1283 0.1416 0.1416
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0731 0.0792 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0083 0.0059 0.1404
Mycobacterium leprae Polyketide synthase Pks13 0.0118 0.0098 0.2071
Trichomonas vaginalis conserved hypothetical protein 0.1771 0.1967 0.3223
Trypanosoma cruzi UDP-galactopyranose mutase 0.0119 0.01 0.099
Echinococcus granulosus c-Jun N-terminal kinases 0.0224 0.0218 0.0218
Loa Loa (eye worm) hypothetical protein 0.0042 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0169 0.0156 0.0156
Trichomonas vaginalis alpha-L-fucosidase, putative 0.0047 0.0018 0.0028
Loa Loa (eye worm) aspartyl protease 6 0.0037 0.0007 0.0007
Onchocerca volvulus 0.0209 0.0201 0.2928
Plasmodium vivax subtilisin-like serine protease, putative 0.0391 0.0407 0.9408
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0112 0.0092 0.0888
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.0792 0.0791
Trypanosoma cruzi UDP-galactopyranose mutase 0.0119 0.01 0.099
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0391 0.0407 1
Trypanosoma brucei SIR2-like protein 4, putative 0.0108 0.0087 0.1086
Plasmodium falciparum protoporphyrinogen oxidase 0.0119 0.01 0.2286
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0312 0.0318 0.3825
Echinococcus multilocularis membrane bound transcription factor site 1 0.0391 0.0407 0.0509
Schistosoma mansoni cathepsin D (A01 family) 0.0037 0.0007 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Giardia lamblia High cysteine membrane protein Group 2 0.3265 0.3658 1
Echinococcus multilocularis epidermal growth factor receptor 0.0623 0.0669 0.0836
Trypanosoma brucei trypanothione synthetase, putative 0.0068 0.0041 0.0511
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0087 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Schistosoma mansoni hypothetical protein 0.0209 0.0201 0.02
Brugia malayi Protein kinase domain containing protein 0.0047 0.0018 0.0018
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0017 0.0017
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0258 0.0256 0.032
Toxoplasma gondii subtilisin SUB8 0.0391 0.0407 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0021 0.0021
Echinococcus multilocularis nmda type glutamate receptor 0.0109 0.0088 0.0109
Loa Loa (eye worm) hypothetical protein 0.0032 0.0001 0.0001
Trichomonas vaginalis beta-hexosaminidase B, putative 0.0047 0.0018 0.0028
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0062 0.0035 0.0453
Brugia malayi transcriptional regulator, Sir2 family protein 0.0108 0.0087 0.0087
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0037 0.0007 0.0006
Brugia malayi CUB domain containing protein 0.0035 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0055 0.0027 0.0027
Loa Loa (eye worm) transcriptional regulator 0.0108 0.0087 0.0087
Leishmania major UDP-galactopyranose mutase 0.0119 0.01 0.1248
Echinococcus multilocularis growth factor receptor bound protein 2 0.014 0.0124 0.0154
Brugia malayi CUB domain containing protein 0.0032 0.0001 0.0001
Echinococcus granulosus c4b binding protein beta chain 0.0038 0.0008 0.0008
Brugia malayi hypothetical protein 0.0037 0.0007 0.0007
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0078 0.0054 0.1274
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0046 0.0017 0.0021
Onchocerca volvulus 0.0038 0.0008 0.0114
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0001 0.0001
Trypanosoma cruzi arginine N-methyltransferase, type I 0.0112 0.0092 0.0888
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0258 0.0256 0.032
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0018 0.0028
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0119 0.01 0.2286
Trypanosoma cruzi Silent information regulator 2 related protein 1 0.0731 0.0792 1
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0731 0.0792 0.1297
Schistosoma mansoni protein kinase 0.0258 0.0256 0.0256
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.005 0.0021 0.0026
Mycobacterium tuberculosis Possible oxidoreductase 0.0119 0.01 0.2414
Schistosoma mansoni protein arginine n-methyltransferase 0.0112 0.0092 0.0091
Schistosoma mansoni discoidin domain receptor 0.0047 0.0018 0.0017
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.2162 0.241 0.3948
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0001 0.0001
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0078 0.0053 0.0911
Schistosoma mansoni chromatin regulatory protein sir2 0.0731 0.0792 0.0791
Loa Loa (eye worm) hypothetical protein 0.0047 0.0018 0.0018
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0119 0.01 0.0099
Echinococcus multilocularis NAD dependent deacetylase sirtuin 7 0.0108 0.0087 0.0108
Onchocerca volvulus 0.0391 0.0407 0.5945
Echinococcus multilocularis expressed protein 0.0372 0.0385 0.0481
Loa Loa (eye worm) hypothetical protein 0.0133 0.0115 0.0115
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0587 0.0629 0.0628
Toxoplasma gondii subtilisin SUB11 0.0391 0.0407 1
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0684 0.0738 0.0923
Schistosoma mansoni amine oxidase 0.0119 0.01 0.0099
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0087 0.0086
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0224 0.0218 0.0218
Trichomonas vaginalis hypothetical protein 0.1771 0.1967 0.3223
Echinococcus granulosus lysine specific histone demethylase 1A 0.0119 0.01 0.0099
Plasmodium falciparum plasmepsin III 0.0037 0.0007 0.0126
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.1771 0.1967 0.3223
Echinococcus multilocularis discoidin domain receptor 0.0047 0.0018 0.0021
Trichomonas vaginalis chromatin regulatory protein sir2, putative 0.0108 0.0087 0.0141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0046 0.0017 0.0017
Schistosoma mansoni chromatin regulatory protein sir2 0.0108 0.0087 0.0086
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0391 0.0407 0.0667

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 37 % Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-7 M ChEMBL. 2170647
Inhibition (functional) = 37 % Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-7 M ChEMBL. 2170647
Inhibition (functional) = 71 % Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-6 M ChEMBL. 2170647
Inhibition (functional) = 71 % Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-6 M ChEMBL. 2170647
Inhibition (functional) = 79 % Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-5 M ChEMBL. 2170647
Inhibition (functional) = 79 % Antagonistic activity against Leukotriene B4 receptor by using [3H]-LTB4 as a radioligand at a concentration of 10e-5 M ChEMBL. 2170647

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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