Detailed information for compound 160090

Basic information

Technical information
  • TDR Targets ID: 160090
  • Name: 4-methyl-3-(2-pyridin-4-yl-1H-indol-5-yl)-1H- 1,2,4-triazol-5-one
  • MW: 291.307 | Formula: C16H13N5O
  • H donors: 2 H acceptors: 4 LogP: 1.79 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1nnc(n1C)c1ccc2c(c1)cc([nH]2)c1ccncc1
  • InChi: 1S/C16H13N5O/c1-21-15(19-20-16(21)22)11-2-3-13-12(8-11)9-14(18-13)10-4-6-17-7-5-10/h2-9,18H,1H3,(H,20,22)
  • InChiKey: HZGRDAKGARZKQW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-3-[2-(4-pyridyl)-1H-indol-5-yl]-1H-1,2,4-triazol-5-one
  • 4-methyl-5-(2-pyridin-4-yl-1H-indol-5-yl)-2H-1,2,4-triazol-3-one
  • 4-methyl-5-[2-(4-pyridyl)-1H-indol-5-yl]-2H-1,2,4-triazol-3-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.0072 0.0245
Schistosoma mansoni follistatin 0.0076 0.1177 0.2475
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0118 0.0247
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0072 0.111 0.2334
Schistosoma mansoni organic anion transporter 0.0112 0.1809 0.3805
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Onchocerca volvulus 0.0112 0.1809 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0012 0.0024 0.0083
Leishmania major cathepsin L-like protease 0.0017 0.0118 0.0401
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0024 0.0083
Echinococcus granulosus Solute carrier organic anion transporter family 0.0112 0.1809 0.6173
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0013 0.0042 0.0089
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0067 0.0141
Schistosoma mansoni ubiquitin-like protein sumo/smt3-related 0.0031 0.0369 0.0777
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Onchocerca volvulus 0.0076 0.1177 0.6503
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0118 0.0401
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0076 0.1177 0.2475
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0135 0.0407
Brugia malayi dehydrogenases, short chain protein 9 0.0012 0.0024 0.0051
Toxoplasma gondii oxidoreductase, putative 0.0012 0.0024 0.0083
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.007 0.1886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0118
Onchocerca volvulus 0.0012 0.0024 0.0134
Schistosoma mansoni organic anion transporter 0.0112 0.1809 0.3805
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0721 0.246
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0012 0.0024 0.0083
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0012 0.0024 0.0083
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0512
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0083
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0024 0.0083
Echinococcus granulosus hypothetical protein 0.0012 0.0024 0.0083
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0067 0.0141
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0012 0.0024 0.0024
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0026 0.0286 0.0601
Echinococcus granulosus intermediate filament protein 0.0026 0.0286 0.0975
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0072 0.1743
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.0024 0.0024
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0024 0.0083
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0024 0.0083
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0135 0.0135
Brugia malayi oxidoreductase 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0024 0.0024
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0012 0.0024 0.0051
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0012 0.0024 0.0083
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.1177 0.2475
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.1177 0.4015
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0012 0.0024 0.0083
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0024 0.0024
Echinococcus multilocularis follistatin 0.0076 0.1177 0.4015
Brugia malayi hypothetical protein 0.0112 0.1809 0.3805
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Schistosoma mansoni carbonyl reductase 0.0012 0.0024 0.0051
Toxoplasma gondii cathepsin CPL 0.0017 0.0118 0.0401
Mycobacterium ulcerans short-chain type oxidoreductase 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0012 0.0024 0.0134
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0243 0.083
Onchocerca volvulus 0.0017 0.0118 0.065
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0072 0.1942
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Loa Loa (eye worm) hypothetical protein 0.0076 0.1177 0.2475
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Brugia malayi hypothetical protein 0.0011 0.0009 0.0019
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0083
Giardia lamblia Hypothetical protein 0.0012 0.0024 0.0659
Echinococcus granulosus agrin 0.0076 0.1177 0.4015
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0024 0.0024
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0012 0.0024 0.0024
Schistosoma mansoni intermediate filament proteins 0.0026 0.0286 0.0601
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0012 0.0024 0.0428
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Toxoplasma gondii transporter, major facilitator family protein 0.0112 0.1809 0.6173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus granulosus follistatin 0.0076 0.1177 0.4015
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0174 0.2931 1
Loa Loa (eye worm) GMP reductase 0.0072 0.111 0.2334
Schistosoma mansoni cathepsin F (C01 family) 0.0011 0.0018 0.0037
Loa Loa (eye worm) IMP dehydrogenase 1 0.0174 0.2931 0.6164
Leishmania major 3-keto-dihydrosphingosine reductase 0.0012 0.0024 0.0083
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0012 0.0024 0.0051
Onchocerca volvulus 0.0012 0.0024 0.0134
Brugia malayi sodium-independent organic anion transporter family protein 0.0112 0.1809 0.3805
Giardia lamblia MRP-like ABC transporter 0.0014 0.0072 0.1942
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0012 0.0024 0.0428
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Leishmania major cathepsin L-like protease 0.0064 0.0968 0.3302
Echinococcus multilocularis agrin 0.0076 0.1177 0.4015
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0968 0.3302
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0092 0.1451 0.1451
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0243 0.083
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0072 0.1743
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0112 0.1809 0.3805
Leishmania major short chain dehydrogenase, putative 0.0012 0.0024 0.0083
Schistosoma mansoni retinal dehydrogenase 0.0012 0.0024 0.0051
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0243 0.6506
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0174 0.2931 1
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Possible oxidoreductase 0.0012 0.0024 0.0024
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0083 0.1295 0.1295
Trypanosoma brucei small ubiquitin-related modifier 0.0031 0.0369 0.126
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0072 0.0245
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0042 0.0144
Schistosoma mansoni lamin 0.0026 0.0286 0.0601
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Trypanosoma cruzi GMP reductase 0.0174 0.2931 1
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0024 0.0428
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0012 0.0024 0.0083
Onchocerca volvulus Putative organic anion transporter 0.0112 0.1809 1
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0118 0.0401
Brugia malayi Retinol dehydrogenase 12 0.0012 0.0024 0.0051
Leishmania major inosine-5-monophosphate dehydrogenase 0.0174 0.2931 1
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0012 0.0024 0.0083
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0118 0.0401
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0083
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0135 0.0492
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0112 0.1809 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0243 0.0243
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0012 0.0024 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0083
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Leishmania major cathepsin L-like protease 0.0064 0.0968 0.3302
Leishmania major dehydrogenase-like protein 0.0012 0.0024 0.0083
Treponema pallidum Mg2+ transport protein (mgtE) 0.001 0 0.5
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0012 0.0024 0.0083
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0012 0.0024 0.0083
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0083
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0112 0.1809 0.6173
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0174 0.2931 0.6164
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0118 0.3014
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0012 0.0024 0.0083
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0118 0.065
Echinococcus granulosus lamin 0.0026 0.0286 0.0975
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0151
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0037
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0243 0.083
Trypanosoma cruzi hypothetical protein 0.0011 0.0012 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0083
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Schistosoma mansoni agrin 0.0076 0.1177 0.2475
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.1177 0.2475
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0243 0.0243
Onchocerca volvulus 0.0017 0.0118 0.065
Onchocerca volvulus 0.0026 0.0286 0.158
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0012 0.0024 0.0024
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0164 0.2746 1
Echinococcus multilocularis Small ubiquitin modifier 2 0.0031 0.0369 0.126
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Loa Loa (eye worm) cysteine protease 0.0017 0.0118 0.0247
Onchocerca volvulus 0.0012 0.0024 0.0134
Treponema pallidum hemolysin (tlyC) 0.001 0 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Onchocerca volvulus 0.0112 0.1809 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Loa Loa (eye worm) hypothetical protein 0.0076 0.1177 0.2475
Echinococcus multilocularis conserved hypothetical protein 0.0012 0.0024 0.0083
Onchocerca volvulus Putative GMP reductase 0.0072 0.111 0.6134
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0037
Onchocerca volvulus 0.0012 0.0024 0.0134
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0072 0.0245
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Trypanosoma cruzi small ubiquitin protein, putative 0.0031 0.0369 0.126
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0018 0.0018
Loa Loa (eye worm) ctsf protein 0.0017 0.0118 0.0247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0118
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Giardia lamblia Reductase, putative 0.0012 0.0024 0.0659
Mycobacterium ulcerans dehydrogenase 0.0012 0.0024 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Brugia malayi Cathepsin L-like precursor 0.0017 0.0118 0.0247
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0024 0.0083
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0012 0.0024 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Brugia malayi glutaminase DH11.1 0.0276 0.4755 1
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0071
Brugia malayi Cathepsin L-like precursor 0.0017 0.0118 0.0247
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0286 0.0601
Trypanosoma brucei GMP reductase 0.0174 0.2931 1
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.0024 0.0024
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0024 0.0083
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0112 0.1809 0.6173
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0072 0.0245
Entamoeba histolytica ubiquitin like protein 0.0031 0.0369 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0118 0.0401
Toxoplasma gondii small ubiquitin family modifier, putative 0.0031 0.0369 0.126
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0174 0.2931 1
Trypanosoma cruzi GMP reductase 0.0174 0.2931 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0024 0.0083
Mycobacterium ulcerans dehydrogenase/reductase 0.0012 0.0024 0.0024
Brugia malayi secreted modular calcium-binding protein 1 0.0076 0.1177 0.2475
Leishmania major cathepsin L-like protease 0.0017 0.0118 0.0401
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0012 0.0024 0.0033
Brugia malayi multidrug resistance related protein 1 0.0014 0.0072 0.0151
Brugia malayi hypothetical protein 0.0112 0.1809 0.3805
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0012 0.0024 0.0083
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0243 0.083
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0012 0.0024 0.0024
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0512
Echinococcus granulosus cathepsin l1 0.0017 0.0118 0.0401
Echinococcus multilocularis oxidoreductase 0.0012 0.0024 0.0083
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0092 0.1451 0.4951
Mycobacterium ulcerans oxidoreductase 0.0012 0.0024 0.0024
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.0024 0.0428
Echinococcus granulosus cathepsin l1 0.0011 0.0018 0.006
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Toxoplasma gondii protease inhibitor PI2 0.0076 0.1177 0.4015
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0284
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0083
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0024 0.0428
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0012 0.0024 0.0024
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0012 0.0024 0.0083
Plasmodium vivax small ubiquitin-related modifier, putative 0.0031 0.0369 0.1268
Echinococcus multilocularis expressed protein 0.0076 0.1177 0.4015
Leishmania major oxidoreductase-like protein 0.0012 0.0024 0.0083
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0174 0.2931 0.2931
Brugia malayi Ubiquitin-like protein SMT3 0.0031 0.0369 0.0777
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0072 0.0245
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0118 0.065
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Brugia malayi cathepsin L-like precursor 0.0011 0.0018 0.0037
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0083
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0012 0.0024 0.0024
Mycobacterium ulcerans hypothetical protein 0.0024 0.0243 0.0243
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0012 0.0024 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0118 0.0229
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.1177 0.4015
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0083
Brugia malayi prostaglandin transporter 0.0112 0.1809 0.3805
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0012 0.0024 0.0089
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Toxoplasma gondii IMP dehydrogenas 0.0174 0.2931 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0243 0.0512
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.0024 0.0024
Brugia malayi Cathepsin L-like precursor 0.0017 0.0118 0.0247
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0012 0.0024 0.0134
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0024 0.0134
Schistosoma mansoni multidrug resistance protein 0.0014 0.0072 0.0151
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0083
Loa Loa (eye worm) dehydrogenase 0.0012 0.0024 0.0051
Onchocerca volvulus 0.0011 0.0009 0.0049
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0011 0.0018 0.0018
Trichomonas vaginalis glutaminase, putative 0.0276 0.4755 1
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0012 0.0024 0.0089
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0118 0.0247
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0083
Leishmania major short chain dehydrogenase-like protein 0.0012 0.0024 0.0083
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0012 0.0024 0.0134
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Toxoplasma gondii carbonyl reductase 1, putative 0.0012 0.0024 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0118
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0012 0.0024 0.0051
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Brugia malayi Cathepsin L-like precursor 0.0011 0.0018 0.0037
Brugia malayi intermediate filament protein 0.0026 0.0286 0.0601
Onchocerca volvulus Putative organic anion transporter 0.0112 0.1809 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0012 0.0024 0.0024
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.1177 0.2475
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0017 0.0118 0.065
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.0072 0.0245
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Leishmania major pentamidine resistance protein 1 0.0014 0.0072 0.0245
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0118 0.0118
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0072 0.1942
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0076 0.1177 0.2475
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0968 0.3302
Giardia lamblia Oxidoreductase, short chain dehydrogenase/reductase family 0.0012 0.0024 0.0659
Loa Loa (eye worm) hypothetical protein 0.0076 0.1177 0.2475
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0968 0.3302
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Brugia malayi Cathepsin L-like precursor 0.0017 0.0118 0.0247
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0118 0.0247
Leishmania major short chain dehydrogenase/reductase, putative 0.0012 0.0024 0.0083
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0072 0.1743
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0076 0.1177 0.2475
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0024 0.0428
Loa Loa (eye worm) hypothetical protein 0.0017 0.0118 0.0247
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Schistosoma mansoni multidrug resistance protein 0.0014 0.0072 0.0151
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0072 0.0245
Onchocerca volvulus 0.0012 0.0024 0.0134
Plasmodium falciparum small ubiquitin-related modifier 0.0031 0.0369 0.1345
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0012 0.0024 0.0033
Echinococcus granulosus steroid dehydrogenase 0.0012 0.0024 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Schistosoma mansoni carbonyl reductase 0.0012 0.0024 0.0051
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0012 0.0024 0.0083
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0174 0.2931 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0112 0.1809 0.6173
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Loa Loa (eye worm) fibroinase 0.0017 0.0118 0.0247
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0286 0.0601
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0369 0.0759
Schistosoma mansoni multidrug resistance protein 0.0014 0.0072 0.0151
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0072 0.0245
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0118 0.0229
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0072 0.111 0.2334
Onchocerca volvulus 0.0024 0.0243 0.1345
Echinococcus granulosus lamin dm0 0.0026 0.0286 0.0975
Brugia malayi Cathepsin L-like precursor 0.0017 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0118 0.0428
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0243 0.083
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0012 0.0024 0.0083
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0012 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0284
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0018 0.0037
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0012 0.0024 0.0083
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Loa Loa (eye worm) glutaminase 0.0276 0.4755 1
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0072 0.1743
Trypanosoma cruzi short chain dehydrogenase, putative 0.0012 0.0024 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Trichomonas vaginalis steroid dehydrogenase, putative 0.0012 0.0024 0.0033
Mycobacterium ulcerans short chain dehydrogenase 0.057 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus granulosus WW domain containing oxidoreductase 0.0012 0.0024 0.0083
Leishmania major short chain dehydrogenase, putative 0.0012 0.0024 0.0083
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0164 0.2746 0.2746
Leishmania major small ubiquitin protein, putative 0.0031 0.0369 0.126
Brugia malayi Dehydrogenases, short chain protein 2 0.0012 0.0024 0.0051
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0174 0.2931 1
Loa Loa (eye worm) multidrug resistance-associated protein 0.0011 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0277 0.0583
Loa Loa (eye worm) hypothetical protein 0.0012 0.0034 0.0071
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0118 0.0401
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0135 1
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0012 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0118 0.0229
Leishmania major pteridine reductase 1 0.0012 0.0024 0.0083
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0072 0.0151
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Leishmania major cathepsin L-like protease 0.0064 0.0968 0.3302
Trypanosoma brucei p-glycoprotein 0.0014 0.0072 0.0245
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0284
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0118 0.0428
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0083
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0174 0.2931 0.6164
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.0072 0.0151
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0243 0.0243
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.0072 0.0245
Brugia malayi sodium-independent organic anion transporter family protein 0.0112 0.1809 0.3805
Echinococcus granulosus retinol dehydrogenase 11 0.0012 0.0024 0.0083
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0118 0.0401
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0014 0.007 0.0146
Leishmania major cathepsin L-like protease 0.0017 0.0118 0.0401
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Loa Loa (eye worm) SMO-1 protein 0.0031 0.0369 0.0777
Echinococcus granulosus hypothetical protein 0.0012 0.0024 0.0083
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0024 0.0243 0.0512
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0243 0.0243
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0072 0.0245
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Brugia malayi Cathepsin L-like precursor 0.0011 0.0018 0.0037
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Leishmania major guanosine monophosphate reductase 0.0174 0.2931 1
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0012 0.0024 0.0051
Onchocerca volvulus Sepiapterin reductase homolog 0.0012 0.0024 0.0134
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0284
Echinococcus multilocularis cysteine protease 0.0017 0.0118 0.0401
Onchocerca volvulus 0.0017 0.0118 0.065
Mycobacterium ulcerans oxidoreductase 0.0012 0.0024 0.0024
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0243 0.0243
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0083
Brugia malayi dehydrogenases, short chain protein 2 0.0012 0.0024 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus multilocularis lamin 0.0026 0.0286 0.0975
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0083 0.1295 0.4418
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0012 0.0024 0.0134
Giardia lamblia Short-chain dehydrogenase, putative 0.0012 0.0024 0.0659
Leishmania major p-glycoprotein e 0.0014 0.0072 0.0245
Giardia lamblia Sentrin 0.0031 0.0369 1
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0012 0.0024 0.0083
Echinococcus multilocularis ubiquitin 0.0011 0.0009 0.003
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0118 0.0401
Mycobacterium ulcerans glutaminase 0.0276 0.4755 0.4755
Onchocerca volvulus 0.0026 0.0286 0.158
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0012 0.0024 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Leishmania major short chain dehydrogenase/reductase, putative 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0011 0.0009 0.0019
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0243 0.0243
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0164 0.2746 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0012 0.0024 0.0083
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.0072 0.0245
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Loa Loa (eye worm) glutaminase 2 0.0276 0.4755 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.1177 0.4015
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0024 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011 0.0012 0.0041
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0083
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Leishmania major cathepsin L-like protease 0.0017 0.0118 0.0401
Entamoeba histolytica short chain dehydrogenase family protein 0.0012 0.0024 0.0428
Brugia malayi SPARC precursor 0.0076 0.1177 0.2475
Onchocerca volvulus 0.0012 0.0024 0.0134
Trypanosoma brucei short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0112 0.1809 1
Onchocerca volvulus 0.0012 0.0024 0.0134
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Loa Loa (eye worm) dehydrogenase 0.0012 0.0024 0.0051
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Echinococcus granulosus ubiquitin 0.0011 0.0009 0.003
Trypanosoma brucei oxidoreductase-like protein 0.0012 0.0024 0.0083
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Brugia malayi hypothetical protein 0.0012 0.0024 0.0051
Echinococcus multilocularis steroid dehydrogenase 0.0012 0.0024 0.0083
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0024 0.0083
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0012 0.0024 0.0083
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0042 0.0144
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0012 0.0024 0.0428
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Mycobacterium ulcerans carveol-like dehydrogenase 0.0012 0.0024 0.0024
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Entamoeba histolytica hypothetical protein 0.0014 0.0072 0.1743
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0012 0.0024 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0118 0.0229
Echinococcus granulosus oxidoreductase 0.0012 0.0024 0.0083
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0012 0.0024 0.0083
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0012 0.0024 0.0083
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0072 0.0245
Brugia malayi Dehydrogenases, short chain protein 30 0.0012 0.0024 0.0051
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0018 0.0135 0.0284
Echinococcus multilocularis cysteine protease 0.0017 0.0118 0.0401
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0174 0.2931 1
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0012 0.0024 0.0051
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0118 0.0247
Echinococcus granulosus multidrug resistance associated protein 4 0.0011 0.0012 0.0041
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0118 0.065
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0012 0.0024 0.0083
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0243 0.0512
Echinococcus multilocularis retinol dehydrogenase 13 0.0012 0.0024 0.0083
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Schistosoma mansoni glutaminase 0.0276 0.4755 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0012 0.0024 0.0024
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0968 0.3302
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0174 0.2931 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Onchocerca volvulus Putative organic anion transporter 0.0112 0.1809 1
Entamoeba histolytica ABC transporter, putative 0.0014 0.0072 0.1743
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0012 0.0024 0.0083
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0012 0.0024 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Entamoeba histolytica cysteine protease, putative 0.0017 0.0118 0.3014
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.0072 0.0245
Echinococcus multilocularis lamin dm0 0.0026 0.0286 0.0975
Plasmodium vivax vivapain-2 0.0017 0.0118 0.0342
Giardia lamblia ABC transporter, putative 0.0014 0.0072 0.1942
Entamoeba histolytica hypothetical protein 0.0012 0.0024 0.0428
Echinococcus multilocularis transient receptor potential cation channel 0.0012 0.0024 0.0083
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0012 0.0024 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0243 0.0243
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0012 0.0024 0.0024
Trypanosoma cruzi hypothetical protein, conserved 0.0012 0.0024 0.0083
Plasmodium vivax vivapain-2 0.0017 0.0118 0.0342
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0072 0.0245
Brugia malayi GMP reductase 0.0072 0.111 0.2334
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Entamoeba histolytica hypothetical protein, conserved 0.0012 0.0024 0.0428
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Onchocerca volvulus 0.0112 0.1809 1
Echinococcus granulosus Small ubiquitin modifier 2 0.0031 0.0369 0.126
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0243 0.0512
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Echinococcus granulosus carbonyl reductase 1 0.0012 0.0024 0.0083
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0012 0.0024 0.0083
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0118 0.3014
Schistosoma mansoni lamin 0.0026 0.0286 0.0601
Echinococcus multilocularis retinol dehydrogenase 11 0.0012 0.0024 0.0083
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0286 0.0601
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0243 0.0243
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0012 0.0024 0.0051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0243 0.6506
Onchocerca volvulus 0.0019 0.015 0.083
Mycobacterium ulcerans ketoacyl reductase 0.0012 0.0024 0.0024
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0017 0.0118 0.065
Leishmania major ABC-thiol transporter 0.0014 0.0072 0.0245
Brugia malayi hypothetical protein 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0012 0.0024 0.0024
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Toxoplasma gondii oxidoreductase, putative 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0017 0.0118 0.065
Echinococcus multilocularis musashi 0.0026 0.0286 0.0975
Schistosoma mansoni carbonyl reductase 0.0012 0.0024 0.0051
Onchocerca volvulus 0.0012 0.0024 0.0134
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0012 0.0024 0.0033
Loa Loa (eye worm) agrin synaptic family protein 0.0076 0.1177 0.2475
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0012 0.0024 0.0024
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Schistosoma mansoni steroid dehydrogenase 0.0012 0.0024 0.0051
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0024 0.0024
Leishmania major hypothetical protein, conserved 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0112 0.1809 0.3805
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0868 0.2961
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0024 0.0083
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0076 0.1177 0.4015
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0174 0.2931 1
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0118 0.0401
Trypanosoma cruzi small ubiquitin protein, putative 0.0031 0.0369 0.126
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0072 0.0245
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0118 0.0247
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0174 0.2931 0.2931
Mycobacterium ulcerans short-chain dehydrogenase 0.0012 0.0024 0.0024
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0012 0.0024 0.0033
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0012 0.0024 0.0024
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Mycobacterium leprae Probable oxidoreductase 0.0012 0.0024 0.0083
Loa Loa (eye worm) hypothetical protein 0.0012 0.0024 0.0051
Loa Loa (eye worm) oxidoreductase 0.0012 0.0024 0.0051
Leishmania major quinonoid dihydropteridine reductase 0.0012 0.0024 0.0083
Onchocerca volvulus 0.0011 0.0018 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0243 0.6506
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Brugia malayi sodium-independent organic anion transporter family protein 0.0112 0.1809 0.3805
Schistosoma mansoni short chain dehydrogenase 0.0012 0.0024 0.0051
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0012 0.0024 0.0083
Schistosoma mansoni multidrug resistance protein 0.0014 0.0072 0.0151
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0118 0.0428
Echinococcus multilocularis carbonyl reductase 1 0.0012 0.0024 0.0083
Leishmania major cathepsin L-like protease 0.0017 0.0118 0.0401
Mycobacterium ulcerans short chain dehydrogenase 0.0012 0.0024 0.0024
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0012 0.0024 0.0024
Onchocerca volvulus 0.0017 0.0118 0.065
Trypanosoma cruzi short chain dehydrogenase, putative 0.0012 0.0024 0.0083
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0968 0.3302
Entamoeba histolytica cysteine proteinase, putative 0.0011 0.0018 0.0239
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0012 0.0024 0.0051
Brugia malayi Cathepsin L-like precursor 0.0017 0.0118 0.0247
Trypanosoma cruzi MFS transporter, putative 0.0112 0.1809 0.6173
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0072 0.0151
Brugia malayi Cathepsin L-like cysteine proteinase 0.0011 0.0018 0.0037
Plasmodium falciparum steroid dehydrogenase, putative 0.0012 0.0024 0.0089
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0072 0.1743

Activities

Activity type Activity value Assay description Source Reference
Max (functional) = 0.4 mmHg s-1 Maximum increase in dP/dt from that of the control in the anesthetized rats at dose 3.0 mg/kg ChEMBL. 2213839

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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