Detailed information for compound 1615345

Basic information

Technical information
  • TDR Targets ID: 1615345
  • Name: 3-(dimethylaminomethyl)-5-[1-(dimethylaminome thyl)-2-oxoindol-3-ylidene]-1,3-thiazolidine- 2,4-dione
  • MW: 360.431 | Formula: C17H20N4O3S
  • H donors: 0 H acceptors: 3 LogP: 1.54 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CN1C(=O)S/C(=C/2\C(=O)N(c3c2cccc3)CN(C)C)/C1=O)C
  • InChi: 1S/C17H20N4O3S/c1-18(2)9-20-12-8-6-5-7-11(12)13(15(20)22)14-16(23)21(10-19(3)4)17(24)25-14/h5-8H,9-10H2,1-4H3/b14-13-
  • InChiKey: IHSVGUNOFKTLFA-YPKPFQOOSA-N  

Network

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Synonyms

  • (5Z)-3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxoindol-3-ylidene]-1,3-thiazolidine-2,4-dione
  • 3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxo-indolin-3-ylidene]thiazolidine-2,4-dione
  • (5Z)-3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxo-indolin-3-ylidene]thiazolidine-2,4-dione
  • (5Z)-3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxo-3-indolinylidene]thiazolidine-2,4-dione
  • 3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxo-3-indolinylidene]thiazolidine-2,4-dione
  • (5Z)-3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-keto-indolin-3-ylidene]thiazolidine-2,4-quinone
  • 3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-keto-indolin-3-ylidene]thiazolidine-2,4-quinone
  • 3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxo-indol-3-ylidene]-1,3-thiazolidine-2,4-dione
  • (5Z)-3-(dimethylaminomethyl)-5-[1-(dimethylaminomethyl)-2-oxo-indol-3-ylidene]-1,3-thiazolidine-2,4-dione
  • NCI363916
  • 2,4-Thiazolidinedione der.
  • 2,4-Thiazolidinedione, 3-[(dimethylamino)methyl]-5-[1-[(dimethylamino)methyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]-, (5Z)-
  • AIDS-030276
  • AIDS030276
  • NCIStruc2_001983
  • 3-((dimethylamino)methyl)-5-(1-((dimethylamino)methyl)-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-1,3-thiazolidine-2,4-dione
  • NCI60_003336
  • 2,4-Thiazolidinedione, 3-[(dimethylamino)methyl]-5-[1-[(dimethylamino)methyl]-1,2-dihydro-2-oxo-3H-indol-3-ylidene]-
  • NSC363916
  • NCIStruc1_001705

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0221 0.0589
Trichomonas vaginalis ferritin, putative 0.0009 0.0003 0.0138
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis cpg binding protein 0.006 0.0158 0.0323
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0504
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0041 0.0336
Echinococcus multilocularis survival motor neuron protein 1 0.0749 0.2266 0.4658
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0049 0.0049
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.0199 0.0198
Wolbachia endosymbiont of Brugia malayi NAD-dependent DNA ligase, Lig 0.001 0.0006 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0029 0.0067
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0006 0.0034
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0028 0.0075
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0018 0.0044
Trypanosoma cruzi kinesin, putative 0.0019 0.0033 0.024
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.0008 0.0001 0.0002
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0081
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0081
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0021 0.0041 0.0326
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0052 0.0135 0.0323
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0135 0.0325
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0935
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0617
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0051 0.0134
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0018 0.0036
Toxoplasma gondii hypothetical protein 0.0048 0.0123 0.0981
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0106
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0135 0.0325
Brugia malayi hypothetical protein 0.0012 0.0012 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0135 0.0274
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Onchocerca volvulus 0.0012 0.0012 0.0029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0135 0.0323
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0033 0.024
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0029 0.0074
Schistosoma mansoni cpg binding protein 0.0057 0.0149 0.0359
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0049 0.0131
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0377
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0574 0.1179
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0022 0.0044 0.0349
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.006 0.0158
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0004 0.0008
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0935
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0412 0.1235 1
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.003 0.0499
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0308
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0006 0.0263
Giardia lamblia Sgs1 DNA helicase, putative 0.0009 0.0002 0.009
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0152
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.004 0.1704
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0617
Brugia malayi CHE-14 protein 0.0085 0.0235 0.0624
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Trypanosoma cruzi UDP-galactopyranose mutase 0.0409 0.1224 1
Echinococcus granulosus ferritin 0.0009 0.0003 0.0005
Brugia malayi nuclear hormone receptor 0.0025 0.0051 0.0134
Brugia malayi beta-lactamase family protein 0.0035 0.0083 0.0221
Loa Loa (eye worm) hypothetical protein 0.1158 0.3513 0.9353
Plasmodium vivax vivapain-2 0.0018 0.003 0.0246
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Loa Loa (eye worm) fatty acid synthase 0.0027 0.0057 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0052 0.0135 0.0355
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0254 0.0753 0.2004
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0021 0.0041 0.004
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0041 0.0334
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.0042
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0009 0.0002 0.0003
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.003 0.0059
Onchocerca volvulus 0.0012 0.0012 0.0029
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0149 0.0392
Echinococcus granulosus GPCR family 2 0.0081 0.0221 0.0533
Schistosoma mansoni calpain (C02 family) 0.0019 0.0033 0.0079
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0049 0.0049
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0409 0.1224 1
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0041 0.0082
Onchocerca volvulus 0.0044 0.0111 0.0292
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0071 0.017
Mycobacterium ulcerans polyketide synthase 0.0027 0.0058 0.0057
Entamoeba histolytica cysteine proteinase 1, putative 0.0009 0.0004 0.0042
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0006 0.0263
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0021 0.0041 0.004
Brugia malayi AMP-binding enzyme family protein 0.0011 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0063 0.0168 0.0445
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0154 0.0447 0.0917
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Schistosoma mansoni transcription factor LCR-F1 0.0154 0.0447 0.1081
Echinococcus granulosus cysteine protease 0.0009 0.0004 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0047 0.0118 0.0313
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0001 0.0002
Brugia malayi steroid hormone receptor 0.0052 0.0135 0.0358
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0021 0.0041 0.0691
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0001 0.0042
Entamoeba histolytica cysteine proteinase 2 0.0009 0.0004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0022 0.0935
Mycobacterium leprae Possible regulatory protein 0.0015 0.0022 0.0171
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Echinococcus granulosus expressed protein 0.0009 0.0003 0.0005
Brugia malayi Cathepsin L-like cysteine proteinase 0.0012 0.0012 0.0031
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0219
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1599 0.4863 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0083 0.0199
Brugia malayi photoreceptor-specific nuclear receptor 0.0052 0.0135 0.0358
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0111 0.0314 0.2531
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0051 0.0101
Onchocerca volvulus Huntingtin homolog 0.0142 0.041 0.109
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0001 0.0003
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0029
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0089 0.3785
Echinococcus multilocularis ferritin 0.0009 0.0003 0.0005
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.0008 0.0001 0.0003
Echinococcus multilocularis FTZ F1 alpha 0.0052 0.0135 0.0274
Loa Loa (eye worm) acyl carrier protein 0.0012 0.0013 0.0032
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0052 0.0135 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0012 0.0012 0.0504
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0935
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0058 0.0153
Trichomonas vaginalis helicase, putative 0.0013 0.0015 0.0617
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0006 0.0016
Echinococcus granulosus Niemann Pick C1 protein 0.0282 0.0839 0.2026
Plasmodium vivax patched family protein, putative 0.0012 0.0012 0.0099
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0001 0.0042
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0051 0.0101
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Mycobacterium ulcerans bacterioferritin BfrB 0.0009 0.0003 0.0003
Echinococcus granulosus nuclear factor of activated T cells 5 0.0303 0.0902 0.2179
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0018 0.0042
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0052 0.0135 0.0323
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0022 0.0152
Mycobacterium tuberculosis Conserved protein 0.0035 0.0083 0.0095
Toxoplasma gondii type I fatty acid synthase, putative 0.0032 0.0072 0.0565
Brugia malayi CXXC zinc finger family protein 0.0057 0.0149 0.0395
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0018 0.0747
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0027 0.0058 0.0066
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0487 0.0999
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0033 0.024
Brugia malayi hypothetical protein 0.0012 0.0012 0.0032
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0409 0.1224 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0004 0.0144
Onchocerca volvulus 0.0018 0.003 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0083 0.0681
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0052 0.0135 0.0358
Mycobacterium tuberculosis Possible oxidoreductase 0.0409 0.1224 0.1399
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0015 0.0022 0.0152
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.0042
Mycobacterium ulcerans polyketide synthase Pks13 0.004 0.0098 0.0098
Schistosoma mansoni hypothetical protein 0.0082 0.0225 0.0544
Brugia malayi calpain family protein 1 0.0063 0.0168 0.0448
Brugia malayi Steroid receptor seven-up type 2 0.0052 0.0135 0.0358
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.003 0.0059
Brugia malayi calpain 5 0.0019 0.0033 0.0087
Onchocerca volvulus 0.0028 0.0062 0.0162
Schistosoma mansoni zinc finger protein 0.0025 0.0051 0.0122
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0006 0.0016
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0049 0.0049
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.024
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0083 0.0095
Schistosoma mansoni coup transcription factor 0.0052 0.0135 0.0325
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0027 0.0058 0.0461
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0049 0.0056
Toxoplasma gondii hypothetical protein 0.0012 0.0012 0.0081
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0027 0.0058 0.0461
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0207 0.3567
Echinococcus granulosus bloom syndrome protein 0.0021 0.004 0.0094
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.3785
Onchocerca volvulus 0.0021 0.0041 0.0106
Loa Loa (eye worm) hypothetical protein 0.0021 0.0041 0.0106
Loa Loa (eye worm) hypothetical protein 0.0073 0.0199 0.0527
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0089 0.3785
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.003 0.007
Onchocerca volvulus 0.0035 0.0083 0.0219
Brugia malayi Nuclear hormone receptor-like 1 0.0052 0.0135 0.0358
Loa Loa (eye worm) hypothetical protein 0.0142 0.041 0.109
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0022 0.0935
Brugia malayi G-protein alpha subunit 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0083 0.0095
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0041 0.0106
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.0199 0.0227
Schistosoma mansoni hypothetical protein 0.0082 0.0225 0.0544
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Loa Loa (eye worm) acetyltransferase 0.0144 0.0415 0.1102
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0052 0.0135 0.0355
Plasmodium falciparum acyl-CoA synthetase 0.0055 0.0143 0.1165
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0006 0.009
Schistosoma mansoni single-minded 0.0059 0.0155 0.0374
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0029 0.0063 0.0502
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.0267
Loa Loa (eye worm) hypothetical protein 0.0749 0.2266 0.603
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0081 0.0221 0.0533
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.003 0.0059
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0617
Schistosoma mansoni amine oxidase 0.0409 0.1224 0.296
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Brugia malayi amine oxidase, flavin-containing family protein 0.0488 0.1467 0.3906
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.007 0.0142
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0052 0.0135 0.0323
Schistosoma mansoni apoferritin-2 0.0009 0.0003 0.0008
Loa Loa (eye worm) hypothetical protein 0.0073 0.0199 0.0527
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Schistosoma mansoni SWI/SNF complex-related 0.008 0.0219 0.0528
Leishmania major cathepsin L-like protease 0.0068 0.0184 0.1498
Plasmodium vivax hypothetical protein, conserved 0.0409 0.1224 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.003 0.0246
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0004 0.0008
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0292
Brugia malayi hypothetical protein 0.0154 0.0447 0.119
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0001 0.0002
Echinococcus multilocularis Niemann Pick C1 protein 0.0282 0.0839 0.1723
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0051 0.0119
Mycobacterium ulcerans polyketide synthase Pks9 0.0018 0.003 0.0029
Brugia malayi calpain 7 0.0019 0.0033 0.0087
Echinococcus granulosus calpain 0.0019 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0055 0.0143 0.0142
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0052 0.0135 0.0274
Onchocerca volvulus Cathepsin L homolog 0.0018 0.003 0.0077
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0041 0.1746
Loa Loa (eye worm) oxidoreductase 0.0021 0.0041 0.0106
Schistosoma mansoni apoferritin-2 0.0009 0.0003 0.0008
Schistosoma mansoni cpg binding protein 0.006 0.0158 0.0383
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0063 0.0062
Echinococcus multilocularis SWI:SNF complex subunit SMARCC2 0.008 0.0219 0.0447
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.033
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0052 0.0135 0.0355
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0089 0.0725
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0083 0.3545
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0014 0.0019 0.0134
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0083 0.0201
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0058 0.0066
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0029 0.0063 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0109
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0009 0.0004 0.0144
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0009 0.0002 0.0002
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.0267
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0415 0.1104
Loa Loa (eye worm) hypothetical protein 0.0142 0.041 0.109
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0031
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0006 0.0042
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0001 0.0002
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0135 0.0358
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.003 0.0072
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.024
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0051 0.0122
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0235 0.048
Brugia malayi Myosin head containing protein 0.0012 0.0012 0.0032
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0006 0.0023
Mycobacterium ulcerans hypothetical protein 0.0035 0.0083 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0221 0.0587
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0747
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0018 0.003 0.0233
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0009 0.0002 0.0002
Schistosoma mansoni nuclear receptor 0.0025 0.0051 0.0122
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0891 0.727
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0094 0.4292
Loa Loa (eye worm) hypothetical protein 0.0409 0.1224 0.3257
Loa Loa (eye worm) hypothetical protein 0.0073 0.0199 0.0527
Plasmodium vivax hypothetical protein, conserved 0.0409 0.1224 1
Schistosoma mansoni hypothetical protein 0.0807 0.2441 0.5903
Entamoeba histolytica SWIRM domain protein 0.008 0.0219 0.3758
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0935
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Brugia malayi hypothetical protein 0.0197 0.0578 0.1538
Echinococcus multilocularis aryl hydrocarbon receptor 0.0015 0.0022 0.0043
Schistosoma mansoni alpha-glucosidase 0.0144 0.0416 0.1005
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0051 0.0119
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0105 0.4456
Schistosoma mansoni hypothetical protein 0.0082 0.0225 0.0544
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0021 0.0041 0.0047
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0009 0.0003 0.0004
Schistosoma mansoni alpha glucosidase 0.0037 0.0089 0.0215
Onchocerca volvulus Fatty acid synthase homolog 0.0048 0.0124 0.0326
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0094 0.1603
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0104 0.0824
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0083 0.3545
Trichomonas vaginalis GTP-binding protein (q) alpha-11 subunit, gna11, putative 0.0008 0.0001 0.0042
Loa Loa (eye worm) cysteine protease 0.0018 0.003 0.0077
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0066 0.0178 0.0428
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0089 0.0234
Leishmania major hypothetical protein, conserved 0.0035 0.0083 0.0679
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0001 0.0002
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0083 0.0095
Mycobacterium tuberculosis Conserved hypothetical protein 0.0158 0.0458 0.0523
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0104 0.1134
Schistosoma mansoni survival motor neuron protein 0.0153 0.0443 0.107
Schistosoma mansoni hypothetical protein 0.0081 0.0221 0.0535
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.0579 0.1542
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0083 0.0083
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0131 0.0316
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0051 0.0131
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0574 0.1389
Brugia malayi Cathepsin L-like precursor 0.0012 0.0012 0.0031
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0052 0.0135 0.0355
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0052 0.0135 0.0358
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0005
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0029 0.0063 0.0071
Echinococcus multilocularis calpain 0.0019 0.0033 0.0065
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0018 0.0047
Brugia malayi nuclear hormone receptor 0.0052 0.0135 0.0358
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0051 0.0131
Plasmodium vivax vivapain-2 0.0018 0.003 0.0246
Onchocerca volvulus 0.0018 0.003 0.0077
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0199 0.1625
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0023
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0079
Echinococcus granulosus dnaJ subfamily B 0.0807 0.2441 0.5902
Echinococcus granulosus calpain 7 C02 family 0.0019 0.0033 0.0077
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0083 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.003 0.0217
Loa Loa (eye worm) hypothetical protein 0.0197 0.0578 0.1535
Onchocerca volvulus 0.0052 0.0135 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0094 0.0767
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0015 0.0022 0.0051
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.0579 0.1399
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0155
Loa Loa (eye worm) DR-78 0.0025 0.0051 0.0131
Loa Loa (eye worm) hypothetical protein 0.0085 0.0235 0.0622
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0051 0.0101
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0089 0.0699
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0415 0.0851
Entamoeba histolytica hypothetical protein 0.008 0.0219 0.3758
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0083 0.0653
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0018 0.0747
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0055 0.0143 0.0163
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0409 0.1224 1
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0051 0.0131 0.0349
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.001 0.0053
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0058 0.0057
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0165 0.1326
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0001 0.0003
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0041 0.0336
Echinococcus granulosus FTZ F1 alpha 0.0052 0.0135 0.0323
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.0199 0.3423
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0008 0.0001 0.0001
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.006 0.0143
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0083 0.3545
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Echinococcus multilocularis cysteine protease 0.0018 0.003 0.0059
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0179
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Echinococcus multilocularis calpain 7 (C02 family) 0.0019 0.0033 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0184 0.1474
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0041 0.0316
Echinococcus multilocularis calpain family protein 1, d 0.0044 0.0111 0.0226
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0051 0.0122
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Echinococcus granulosus survival motor neuron protein 1 0.0749 0.2266 0.5478
Schistosoma mansoni hypothetical protein 0.0166 0.0483 0.1168
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0006 0.0015
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0018 0.0042
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0009 0.0003 0.0004
Loa Loa (eye worm) RecQ helicase 0.0021 0.004 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0263
Entamoeba histolytica hypothetical protein 0.0154 0.0447 0.771
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0006 0.0263
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Leishmania major kinesin, putative 0.0019 0.0033 0.0267
Loa Loa (eye worm) hypothetical protein 0.0031 0.0071 0.0185
Schistosoma mansoni steroid hormone receptor ad4bp 0.0052 0.0135 0.0325
Onchocerca volvulus 0.0012 0.0012 0.0029
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0041 0.0308
Echinococcus multilocularis cysteine protease 0.0018 0.003 0.0059
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0303 0.0902 0.1853
Schistosoma mansoni nuclear receptor 0.0025 0.0051 0.0122
Brugia malayi cathepsin L-like precursor 0.0012 0.0012 0.0031
Mycobacterium leprae Polyketide synthase Pks13 0.004 0.0098 0.0793
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0049 0.0056
Echinococcus granulosus SWI:SNF complex subunit SMARCC2 0.008 0.0219 0.0526
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0051 0.0134
Brugia malayi protein C24B5.3 0.0012 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0377
Echinococcus granulosus tumor protein p63 0.0347 0.1036 0.2504
Toxoplasma gondii cathepsin CPL 0.0018 0.003 0.0226
Loa Loa (eye worm) calpain family protein 1 0.0063 0.0168 0.0445
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0133 0.0152
Loa Loa (eye worm) hypothetical protein 0.0018 0.003 0.0077
Onchocerca volvulus 0.0073 0.0199 0.0527
Schistosoma mansoni hypothetical protein 0.0166 0.0483 0.1168
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0079
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0343 0.0828
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0006 0.0263
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0047 0.0118 0.0134
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.0267
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0006 0.0023
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0089 0.1518
Echinococcus granulosus lysine specific histone demethylase 1A 0.1158 0.3513 0.8497
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0029
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0409 0.1224 1
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0079
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0196 0.0574 0.1526
Brugia malayi DKFZp564C0469 protein 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Trypanosoma cruzi UDP-galactopyranose mutase 0.0409 0.1224 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0052 0.0135 0.0358
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.007 0.0184
Echinococcus granulosus microtubule associated protein 2 0.1361 0.4134 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0219
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.0199 0.0198
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0617
Mycobacterium ulcerans acetyl-CoA synthetase 0.0021 0.0041 0.004
Leishmania major cysteine peptidase A (CPA) 0.0018 0.003 0.0244
Brugia malayi Patched protein homolog 1 0.0012 0.0012 0.0032
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0018 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Onchocerca volvulus 0.1237 0.3756 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0574 0.1387
Brugia malayi bHLH-PAS transcription factor 0.0043 0.0108 0.0288
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0081 0.0221 0.0453
Leishmania major protein kinase, putative 0.0015 0.0022 0.0179
Brugia malayi beta-lactamase 0.0035 0.0083 0.0221
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0006 0.0052
Schistosoma mansoni ferritin light chain 0.0009 0.0003 0.0008
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0083 0.0671
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0033 0.033
Brugia malayi SWIRM domain containing protein 0.1237 0.3756 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0747
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0199 0.1625
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0018 0.0143
Echinococcus multilocularis microtubule associated protein 2 0.1361 0.4134 0.8502
Echinococcus multilocularis calpain 5 0.0019 0.0033 0.0065
Schistosoma mansoni GTP-binding protein alpha subunit 0.0008 0.0001 0.0002
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0052 0.0135 0.0323
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0219
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0263
Onchocerca volvulus 0.0018 0.003 0.0077
Onchocerca volvulus 0.0012 0.0012 0.0029
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.0487 0.1296
Loa Loa (eye worm) hypothetical protein 0.008 0.0219 0.0579
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.2872 0.8751 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0009 0.0004 0.0004
Echinococcus granulosus aryl hydrocarbon receptor 0.0015 0.0022 0.0051
Loa Loa (eye worm) hypothetical protein 0.0198 0.0579 0.154
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0017 0.0026 0.0194
Mycobacterium tuberculosis Polyketide synthase Pks13 0.004 0.0098 0.0112
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Plasmodium vivax vivapain-3 0.0009 0.0004 0.003
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.003 0.0499
Loa Loa (eye worm) calpain family protein 1 0.0044 0.0111 0.0292
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.0008 0.0001 0.0002
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0048 0.0123 0.0323
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0184 0.1474
Schistosoma mansoni thyroid hormone receptor 0.0052 0.0135 0.0325
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0154 0.0447 0.1079
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.000000000098663
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0133 0.0152
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.1158 0.3513 0.9353
Echinococcus multilocularis GPCR, family 2 0.0081 0.0221 0.0453
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Trichomonas vaginalis esterase, putative 0.0035 0.0083 0.3545
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.3785
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0409 0.1224 1
Brugia malayi hypothetical protein 0.0012 0.0012 0.0032
Onchocerca volvulus 0.0012 0.0012 0.0029
Onchocerca volvulus Protein ultraspiracle homolog 0.0052 0.0135 0.0355
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.003 0.0079
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0066 0.0178 0.0364
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0135 0.0323
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.001 0.008
Onchocerca volvulus 0.0047 0.0118 0.0311
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0052 0.0135 0.0325
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0199 0.0198
Treponema pallidum DNA ligase (lig) 0.001 0.0006 1
Schistosoma mansoni ferritin 0.0009 0.0003 0.0008
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0142 0.0409 0.4566
Brugia malayi tailless protein 0.0025 0.0051 0.0134
Onchocerca volvulus 0.0153 0.0443 0.1175
Onchocerca volvulus 0.0025 0.0051 0.0131
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0221 0.0533
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0263
Onchocerca volvulus 0.0035 0.0083 0.0219
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.3785
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Onchocerca volvulus 0.0015 0.0022 0.0056
Schistosoma mansoni DNA helicase recq5 0.0009 0.0002 0.0005
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0083 0.0095
Schistosoma mansoni ferritin 0.0009 0.0003 0.0008
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0021 0.0041 0.004
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0051 0.0122
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0029 0.0063 0.0502
Mycobacterium tuberculosis Probable thioesterase TesA 0.0022 0.0044 0.005
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0244
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0022 0.0152
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0617
Toxoplasma gondii histone lysine-specific demethylase 0.0409 0.1224 0.9914
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0041 0.0308
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0015 0.0617
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0052 0.0135 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0052 0.0135 0.0358
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0041 0.0334
Trichomonas vaginalis GTP-binding protein (z) alpha subunit, gnaz, putative 0.0008 0.0001 0.0042
Schistosoma mansoni cpg binding protein 0.006 0.0158 0.0383
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0083 0.0095
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0052 0.0135 0.0325
Plasmodium vivax vivapain-1 0.0009 0.0004 0.003
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0051 0.0134
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0018 0.0044
Trypanosoma cruzi kinesin, putative 0.0019 0.0033 0.024
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0006 0.0263
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0105 0.0832
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0001 0.0042
Schistosoma mansoni hypothetical protein 0.0031 0.007 0.0169
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.0199 0.0227
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0009 0.0004 0.0008
Brugia malayi protein C24B5.3 0.0012 0.0012 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Onchocerca volvulus Cathepsin L homolog 0.0018 0.003 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Brugia malayi latrophilin 2 splice variant baaae 0.0174 0.0507 0.1349
Mycobacterium tuberculosis Conserved protein 0.0035 0.0083 0.0095
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0033 0.0079
Onchocerca volvulus 0.0025 0.0051 0.0131
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0006 0.0031
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.0042
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Echinococcus multilocularis thyroid hormone receptor alpha 0.0052 0.0135 0.0274
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0029 0.0063 0.0071
Leishmania major UDP-galactopyranose mutase 0.0409 0.1224 1
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.0008 0.0001 0.0002
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0015 0.0022 0.0056
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0055 0.0143 0.1119
Echinococcus granulosus cathepsin L 0.0009 0.0004 0.0006
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0041 0.0099
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0009 0.0002 0.0018
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0022 0.0042 0.0041
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0018 0.0747
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.0487 0.1175
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.0579 1
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0021 0.0041 0.0047
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0049 0.0394
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0049 0.0049
Echinococcus multilocularis expressed protein 0.0009 0.0003 0.0005
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0747
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0219
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Echinococcus granulosus calpain A 0.0019 0.0033 0.0077
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0022 0.0935
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0022 0.0935
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0377
Schistosoma mansoni DNA ligase IV 0.001 0.0006 0.0015
Echinococcus multilocularis tumor protein p63 0.0347 0.1036 0.2129
Brugia malayi beta-lactamase family protein 0.0035 0.0083 0.0221
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0155
Onchocerca volvulus Huntingtin homolog 0.0142 0.041 0.109
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0747
Echinococcus multilocularis 0.0409 0.1224 0.2516
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0052 0.0135 0.0355
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.006 0.0141
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0235 0.0565
Entamoeba histolytica SWIRM domain protein 0.008 0.0219 0.3758
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0006 0.0006
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.003 0.007
Schistosoma mansoni patched 1 0.0085 0.0235 0.0567
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0033 0.024
Loa Loa (eye worm) calpain 5 0.0019 0.0033 0.0084
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0047
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.0008 0.0001 0.0003
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0027 0.0058 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0052 0.0135 0.0325
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0104 0.0824
Schistosoma mansoni hypothetical protein 0.0082 0.0225 0.0544
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0133 0.0152
Mycobacterium leprae Probable polyketide synthase Pks1 0.0029 0.0063 0.0502
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0089 0.3785
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0019 0.0033 0.024
Brugia malayi SWIRM domain containing protein 0.008 0.0219 0.0581
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Schistosoma mansoni ferritin 0.0009 0.0003 0.0008
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0105 0.0832
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0022 0.0043 0.0048
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0047
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0001 0.0002
Echinococcus multilocularis geminin 0.0166 0.0483 0.0991
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Brugia malayi PAS domain containing protein 0.0059 0.0155 0.0412
Brugia malayi hypoxia-induced factor 1 0.0182 0.0531 0.1413
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.03 0.0891 0.727
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0004 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0083 0.3545
Schistosoma mansoni hypothetical protein 0.0153 0.0443 0.107
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0292
Echinococcus granulosus calpain A 0.0066 0.0178 0.0428
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0022 0.0152
Brugia malayi hypothetical protein 0.0749 0.2266 0.6031
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.003 0.0246
Trypanosoma cruzi major cysteine proteinase, putative 0.0054 0.0139 0.1109
Trypanosoma brucei antigen, putative 0.0019 0.0033 0.033
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.0008 0.0001 0.0003
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0199 0.053
Onchocerca volvulus 0.0012 0.0012 0.0029
Mycobacterium tuberculosis Conserved protein 0.0035 0.0083 0.0095
Echinococcus multilocularis dnaJ subfamily B 0.0807 0.2441 0.5018
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0011 0.001 0.0072
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0021 0.0041 0.0326
Entamoeba histolytica cysteine protease, putative 0.0018 0.003 0.0499
Echinococcus multilocularis bloom syndrome protein 0.0021 0.004 0.008
Loa Loa (eye worm) calpain 0.0019 0.0033 0.0084
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0235 0.0565
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0051 0.0119
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Echinococcus granulosus death domain containing protein 0.0031 0.007 0.0167
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0047
Brugia malayi Death domain containing protein 0.0031 0.007 0.0186
Mycobacterium leprae Probable lipase LipE 0.0035 0.0083 0.0671
Mycobacterium ulcerans hypothetical protein 0.0158 0.0458 0.0457
Schistosoma mansoni hypothetical protein 0.0081 0.0221 0.0535
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis protoporphyrinogen oxidase 0.0409 0.1224 0.2516
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0409 0.3338
Chlamydia trachomatis protoporphyrinogen oxidase 0.0409 0.1224 1
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0006 0.0034
Brugia malayi topoisomerase 0.001 0.0006 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0135 0.0358
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.0487 0.0999
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0089 0.0181
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.3785
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0052 0.0135 0.0355
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0083 0.0898
Brugia malayi hypothetical protein 0.0012 0.0012 0.0032
Brugia malayi nuclear receptor NHR-67 0.0025 0.0051 0.0134
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0006 0.0052
Echinococcus multilocularis ecdysone induced protein 78C 0.0052 0.0135 0.0274
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0574 0.1389
Plasmodium falciparum protoporphyrinogen oxidase 0.0409 0.1224 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Loa Loa (eye worm) hypothetical protein 0.1237 0.3756 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0052 0.0135 0.0355
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0009 0.0002 0.0002
Giardia lamblia Replication factor C, subunit 1 0.001 0.0006 0.0282
Onchocerca volvulus 0.0051 0.0131 0.0345
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0135 0.0274
Onchocerca volvulus 0.0043 0.0108 0.0285
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0052 0.0135 0.0274
Schistosoma mansoni topbp1 0.001 0.0006 0.0015
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0199 0.0198
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0033 0.024
Mycobacterium ulcerans polyketide synthase 0.0029 0.0063 0.0062
Echinococcus multilocularis protein dispatched 1 0.0097 0.0271 0.0556
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0132 0.1055
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0052 0.0135 0.0325
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0001 0.0002
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0021 0.0041 0.0047
Trypanosoma brucei mitochondrial DNA polymerase beta 0.03 0.0891 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Mycobacterium ulcerans fatty acid synthase Fas 0.0008 0.0001 0.0001
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0049 0.0056
Echinococcus multilocularis expressed conserved protein 0.0186 0.0543 0.1114
Schistosoma mansoni blooms syndrome DNA helicase 0.0017 0.0027 0.0064
Onchocerca volvulus 0.0068 0.0184 0.0487
Brugia malayi Patched related family protein 4 0.0012 0.0012 0.0032
Leishmania major protein kinase, putative 0.0015 0.0022 0.0179
Loa Loa (eye worm) hypothetical protein 0.0488 0.1467 0.3904
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0051 0.0134
Onchocerca volvulus 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0104 0.0293 0.0777
Brugia malayi Patched related family protein 12 0.0012 0.0012 0.0032
Plasmodium vivax acyl-CoA synthetase, putative 0.0055 0.0143 0.1165
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0022 0.0042 0.0329
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0105 0.025
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Schistosoma mansoni RAR-like nuclear receptor 0.0052 0.0135 0.0325
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0052 0.0135 0.0358
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0051 0.0134
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Brugia malayi hypothetical protein 0.0028 0.006 0.0158
Entamoeba histolytica hypothetical protein 0.0154 0.0447 0.771
Plasmodium falciparum cysteine proteinase falcipain 1 0.0009 0.0004 0.003
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0104 0.0824
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Mycobacterium ulcerans putative regulatory protein 0.0043 0.0108 0.0108
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0081 0.0221 0.0587
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0022 0.0129
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Brugia malayi hypothetical protein 0.001 0.0006 0.0016
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.0008 0.0001 0.0003
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0105 0.0855
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0021 0.0041 0.004
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0135 0.0358
Toxoplasma gondii ABC1 family protein 0.0035 0.0083 0.0658
Schistosoma mansoni retinoic acid receptor RXR 0.0052 0.0135 0.0325
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0196 0.0574 0.1179
Echinococcus multilocularis hypothetical protein 0.0019 0.0033 0.0065
Echinococcus granulosus nibrin 0.001 0.0006 0.0013
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0041 0.0423
Onchocerca volvulus Protein patched homolog 0.0012 0.0012 0.0029
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.007 0.0142
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0083 0.3545
Giardia lamblia hypothetical protein 0.008 0.0219 1
Brugia malayi calpain family protein 1 0.0063 0.0168 0.0448
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0377
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0263
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0052 0.0135 0.0325
Echinococcus granulosus geminin 0.0166 0.0483 0.1166
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0017 0.0029 0.0216
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0033 0.033
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0008 0.0001 0.0001
Schistosoma mansoni calpain-7 (C02 family) 0.0019 0.0033 0.0079
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0049 0.0049
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0019 0.0032 0.0264
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0263
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0018 0.0159
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0196 0.0574 0.1389
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.007 0.0186
Onchocerca volvulus 0.0018 0.003 0.0077
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0052 0.0135 0.0358
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.0008 0.0001 0.0002
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0199 0.053
Toxoplasma gondii SWIRM domain-containing protein 0.008 0.0219 0.1755
Brugia malayi hypothetical protein 0.0409 0.1224 0.3258
Schistosoma mansoni netrin receptor unc5 0.0031 0.007 0.0169
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.0199 0.0198
Loa Loa (eye worm) hypothetical protein 0.0009 0.0002 0.0003
Echinococcus granulosus replication factor c subunit 1 0.001 0.0006 0.0013
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0018 0.0036
Schistosoma mansoni calpain C (C02 family) 0.0019 0.0033 0.0079
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0155
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0155
Trypanosoma brucei glucosidase, putative 0.0037 0.0089 0.0962
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0196 0.0574 0.1387
Echinococcus granulosus cathepsin l1 0.0018 0.003 0.007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0052 0.0135 0.0358
Brugia malayi ecdysone receptor 0.0025 0.0051 0.0134
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.0199 0.3423
Schistosoma mansoni microtubule-associated protein tau 0.1361 0.4134 1
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0023
Onchocerca volvulus 0.0018 0.003 0.0077
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0029 0.0063 0.0062
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0026 0.0055 0.0063
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0225 0.0665 0.0759
Onchocerca volvulus Protein patched homolog 0.0012 0.0012 0.0029
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0079
Mycobacterium ulcerans hypothetical protein 0.0073 0.0199 0.0198
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0184 0.2028
Brugia malayi nuclear receptor NHR-88 0.0052 0.0135 0.0358
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0254 0.0753 0.2002
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0019 0.0033 0.024
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.003 0.1274
Mycobacterium ulcerans acyl-CoA synthetase 0.0021 0.0041 0.004
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0052 0.0135 0.0274
Brugia malayi nuclear receptor RXR 0.0028 0.006 0.0158
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.0008 0.0001 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0235 1
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0089 0.3785
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0026 0.0055 0.0063
Entamoeba histolytica recQ family helicase, putative 0.0011 0.001 0.0153
Plasmodium vivax calpain, putative 0.0019 0.0033 0.0269
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0041 0.0316
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0244
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0051 0.0122
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0041 0.0316
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0244
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0022 0.0935
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0041 0.1746
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0199 0.1618
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0219 0.9311
Schistosoma mansoni hypothetical protein 0.0174 0.0507 0.1226
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0415 0.1003
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0105 0.4456
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0033 0.033
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0409 0.1224 0.1223
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0423
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0051 0.0101
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0221 0.0453
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypoxia-induced factor 1 0.0182 0.0531 0.1411
Onchocerca volvulus 0.0097 0.0271 0.0719
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0219
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.003 0.0077
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.0579 0.1189
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Entamoeba histolytica cysteine proteinase, putative 0.0009 0.0004 0.0042
Brugia malayi AMP-binding enzyme family protein 0.0073 0.0199 0.053
Schistosoma mansoni hypothetical protein 0.0081 0.0221 0.0535
Echinococcus granulosus cathepsin l1 0.0012 0.0012 0.0026
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0022 0.0042 0.0041
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0184 0.1474
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0052 0.0135 0.0358
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0018 0.0044
Loa Loa (eye worm) fibroinase 0.0018 0.003 0.0077
Brugia malayi hypothetical protein 0.0025 0.0051 0.0134
Schistosoma mansoni hypothetical protein 0.0154 0.0447 0.1081
Echinococcus granulosus expressed conserved protein 0.0186 0.0543 0.131
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0089 0.3785
Onchocerca volvulus Netrin receptor homolog 0.0031 0.007 0.0184
Brugia malayi Patched related family protein 10 0.0012 0.0012 0.0032
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.0487 0.1293
Loa Loa (eye worm) patched family protein 0.0012 0.0012 0.0029
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0051 0.0119
Schistosoma mansoni topbp1 0.001 0.0006 0.0015
Schistosoma mansoni amine oxidase 0.0409 0.1224 0.296
Echinococcus granulosus Ankyrin 0.0031 0.0071 0.0168
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0019 0.0034 0.0039
Mycobacterium ulcerans thioesterase 0.0022 0.0044 0.0043
Trichomonas vaginalis GTP-binding protein alpha subunit, gna, putative 0.0008 0.0001 0.0042
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0178 0.0431
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.0199 0.1625
Entamoeba histolytica hypothetical protein 0.001 0.0006 0.009
Toxoplasma gondii patched family protein 0.0012 0.0012 0.0081
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0009 0.0002 0.0002
Plasmodium vivax unspecified product 0.0009 0.0004 0.003
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0049 0.0056
Leishmania major cathepsin L-like protease 0.0018 0.003 0.0244
Mycobacterium ulcerans oxidoreductase 0.0409 0.1224 0.1223
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.003 0.0072
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis calpain A 0.0066 0.0178 0.0364
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0014 0.0019 0.0157
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0089 0.1518
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0041 0.0109
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0083 0.0169
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Trypanosoma brucei calpain-like protein, putative 0.0019 0.0033 0.033
Loa Loa (eye worm) hypothetical protein 0.0254 0.0753 0.2002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0052 0.0135 0.0358
Trichomonas vaginalis DNA helicase recq, putative 0.0011 0.001 0.0419
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0063 0.0168 0.0407
Loa Loa (eye worm) hypothetical protein 0.0063 0.0168 0.0445
Leishmania major cathepsin L-like protease 0.0068 0.0184 0.1498
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0015 0.0022 0.0152
Schistosoma mansoni cathepsin F (C01 family) 0.0012 0.0012 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Onchocerca volvulus Bile acid receptor homolog 0.0052 0.0135 0.0355
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0308
Loa Loa (eye worm) hypothetical protein 0.0028 0.006 0.0155
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0014 0.0018 0.0286
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0052 0.0135 0.0358
Brugia malayi hypothetical protein 0.0142 0.041 0.1092
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0083 0.0201
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus granulosus cpg binding protein 0.006 0.0158 0.038
Entamoeba histolytica calpain large subunit domain III containing protein 0.0019 0.0033 0.0548
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0015 0.0022 0.0025
Onchocerca volvulus 0.0012 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Mycobacterium ulcerans dehydrogenase 0.0409 0.1224 0.1223
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0015 0.0617
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0051 0.0122
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0029 0.0057
Echinococcus granulosus lysine specific histone demethylase 1A 0.0409 0.1224 0.2959
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0235 0.0622
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0052 0.0133 0.0152
Trichomonas vaginalis GTP-binding protein (O) alpha subunit, gnao, putative 0.0008 0.0001 0.0042
Trichomonas vaginalis G protein (olf) alpha subunit, gnal, putative 0.0008 0.0001 0.0042
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.0008 0.0001 0.0002
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0041 0.0097
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0009 0.0003 0.0018
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.003 0.0077
Entamoeba histolytica protein kinase, putative 0.0019 0.0033 0.0548
Loa Loa (eye worm) ctsf protein 0.0018 0.003 0.0077
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.004 0.0098 0.0112
Brugia malayi Papain family cysteine protease containing protein 0.0009 0.0004 0.0009
Schistosoma mansoni DNA helicase recq1 0.0009 0.0002 0.0005
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0019 0.0033 0.024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.0199 0.0198
Schistosoma mansoni hypothetical protein 0.0081 0.0221 0.0535
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.006 0.012
Echinococcus granulosus netrin receptor unc 5 0.0031 0.007 0.0167
Echinococcus granulosus single minded 2 0.0043 0.0108 0.0259
Loa Loa (eye worm) hypothetical protein 0.0174 0.0507 0.1347
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.0032 0.0036
Loa Loa (eye worm) hypothetical protein 0.0035 0.0083 0.0219
Echinococcus multilocularis Ankyrin 0.0031 0.0071 0.0143
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0066 0.0178 0.0431
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0052 0.0135 0.0355
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0079
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0041 0.0109
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0196 0.0574 0.1529
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0142 0.0409 0.3319
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0027 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0054
Echinococcus multilocularis nibrin 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0409 0.1224 0.3257
Brugia malayi Protein kinase domain containing protein 0.0031 0.007 0.0186
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Loa Loa (eye worm) steroid hormone receptor 0.0052 0.0135 0.0355
Toxoplasma gondii type I fatty acid synthase, putative 0.0019 0.0034 0.0258
Schistosoma mansoni alpha-glucosidase 0.0144 0.0416 0.1005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Echinococcus multilocularis cathepsin L 0.0009 0.0004 0.0005
Leishmania major cathepsin L-like protease 0.0068 0.0184 0.1498
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0083 0.0653
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0221 0.0589
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.0008 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0051 0.0119
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.004 0.1704
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0058 0.0057
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0047 0.0118 0.0311
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0083 0.0219
Loa Loa (eye worm) hypothetical protein 0.0051 0.0131 0.0345
Mycobacterium tuberculosis Conserved hypothetical protein 0.0409 0.1224 0.1399
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis protein patched 0.0085 0.0235 0.048
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0083 0.0095
Brugia malayi Cathepsin L-like precursor 0.0018 0.003 0.0079
Onchocerca volvulus 0.0035 0.0083 0.0219
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0019 0.0033 0.033
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0018 0.003 0.0029
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0051 0.0101
Brugia malayi nuclear receptor NHR-88 0.0025 0.0051 0.0134
Echinococcus multilocularis transfer RNA-Lys 0.0043 0.0108 0.022
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0006 0.0011
Echinococcus granulosus ecdysone induced protein 78C 0.0052 0.0135 0.0323
Brugia malayi nuclear receptor RXR 0.0025 0.0051 0.0134
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0009 0.0002 0.0005
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.004 0.0106
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.003 0.1274
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.0199 0.1618
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.006 0.0158
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0083 0.0221
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0022 0.0935
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0083 0.0083
Echinococcus granulosus calpain 5 0.0019 0.0033 0.0077
Loa Loa (eye worm) hypothetical protein 0.0017 0.0027 0.0069
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0015 0.0617
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0051 0.0134
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0089 0.0704
Entamoeba histolytica hypothetical protein 0.0154 0.0447 0.771
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Brugia malayi ecdysteroid receptor 0.0052 0.0135 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.003 0.1274
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0089 0.0212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.003 0.1274
Schistosoma mansoni Mername-AA248 (C02 family) 0.0019 0.0033 0.0079
Loa Loa (eye worm) beta-lactamase 0.0035 0.0083 0.0219
Echinococcus granulosus cathepsin L cysteine protease 0.0009 0.0004 0.0006
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0041 0.0334
Entamoeba histolytica hypothetical protein 0.0154 0.0447 0.771
Schistosoma mansoni Lysine-specific histone demethylase 1 0.1158 0.3513 0.8497
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0409 0.1224 0.296
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0051 0.0119
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0153 0.0443 0.1178
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.003 0.0059
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Onchocerca volvulus 0.0018 0.003 0.0077
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.003 0.0246
Echinococcus granulosus histone acetyltransferase KAT2B 0.014 0.0403 0.0971
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0022 0.0935
Brugia malayi Patched family protein 0.0012 0.0012 0.0032
Entamoeba histolytica cysteine proteinase, putative 0.0012 0.0012 0.0187
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Echinococcus multilocularis lysine specific histone demethylase 1A 0.1158 0.3513 0.7224
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0051 0.0131
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0015 0.0022 0.0043
Brugia malayi Calcitonin receptor-like protein seb-1 0.0254 0.0753 0.2004
Loa Loa (eye worm) hypothetical protein 0.0055 0.0143 0.0377
Schistosoma mansoni ferritin light chain 0.0009 0.0003 0.0008
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.007 0.0167
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0089 0.0699
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0051 0.0131
Mycobacterium ulcerans lipase LipD 0.0035 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.008 0.0219 0.9311
Leishmania major mitochondrial DNA polymerase beta 0.03 0.0891 0.7278
Loa Loa (eye worm) hypothetical protein 0.0031 0.007 0.0184
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0018 0.0116
Onchocerca volvulus 0.0018 0.003 0.0077
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.006 0.0155
Schistosoma mansoni ferritin 0.0009 0.0003 0.0008
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.0589 0.1424
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0051 0.0101
Onchocerca volvulus 0.0057 0.0149 0.0392
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0018 0.0747
Plasmodium falciparum lipid/sterol:H+ symporter 0.0012 0.0012 0.0099
Brugia malayi hypothetical protein 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0015 0.0022 0.0056
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0089 0.0236
Onchocerca volvulus Cathepsin F homolog 0.0018 0.003 0.0077
Mycobacterium ulcerans Type I modular polyketide synthase 0.0027 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.0012 0.0012 0.0029
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.007 0.0169
Loa Loa (eye worm) hypothetical protein 0.001 0.0006 0.0014
Brugia malayi Uncoordinated protein 44 0.0031 0.007 0.0186
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.0199 0.0198
Onchocerca volvulus 0.001 0.0006 0.0014
Schistosoma mansoni trimeric G-protein alpha o subunit 0.0008 0.0001 0.0002
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0011 0.0009 0.001
Brugia malayi hypothetical protein 0.0008 0.0001 0.0003
Schistosoma mansoni aryl hydrocarbon receptor 0.0059 0.0155 0.0374
Mycobacterium ulcerans thioesterase TesA 0.0022 0.0044 0.0043
Brugia malayi hypothetical protein 0.0025 0.0051 0.0134
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0051 0.0131
Brugia malayi hypothetical protein 0.0028 0.006 0.0158
Brugia malayi conserved hypotetical protein 0.0025 0.0051 0.0134
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0015 0.0617
Loa Loa (eye worm) hypothetical protein 0.0052 0.0135 0.0355
Loa Loa (eye worm) hypothetical protein 0.0025 0.0051 0.0131
Mycobacterium ulcerans monoamine oxidase 0.0409 0.1224 0.1223
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0184 0.1474
Entamoeba histolytica cysteine protease, putative 0.0009 0.0004 0.0042
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.006 0.0143
Trypanosoma brucei kinesin, putative 0.0019 0.0033 0.033
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0052 0.0135 0.0323
Mycobacterium ulcerans bacterioferritin BfrA 0.0009 0.0003 0.0003
Mycobacterium ulcerans beta-lactamase 0.0035 0.0083 0.0083

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.74 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.663 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.626 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.504 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.493 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.413 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.392 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.37 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.36 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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