Detailed information for compound 1636573

Basic information

Technical information
  • TDR Targets ID: 1636573
  • Name: methyl-tri(prop-2-ynyl)azanium
  • MW: 146.209 | Formula: C10H12N+
  • H donors: 0 H acceptors: 0 LogP: 0.62 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: C#CC[N+](CC#C)(CC#C)C
  • InChi: 1S/C10H12N/c1-5-8-11(4,9-6-2)10-7-3/h1-3H,8-10H2,4H3/q+1
  • InChiKey: LKAHLPBXLNUNQZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • methyl-tri(prop-2-ynyl)ammonium
  • methyl-tripropargyl-ammonium
  • NCI60_007546

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0024 0.0038 0.0341
Loa Loa (eye worm) MH2 domain-containing protein 0.011 0.0591 0.0662
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0216 0.0242
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0024 0.0038 0.5144
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0038 0.0071
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.012 0.0653 0.2536
Trichomonas vaginalis PIKK family atypical protein kinase 0.0245 0.1462 0.2735
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0052 0.0216 0.0404
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0133 0.0738 0.138
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0052 0.0216 0.2885
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0074 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0301 0.1827 0.3419
Onchocerca volvulus Alhambra homolog 0.0029 0.0066 0.0021
Loa Loa (eye worm) hypothetical protein 0.0063 0.0285 0.032
Giardia lamblia Phosphatidylinositol 4-kinase 0.0052 0.0216 0.0827
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0216 0.0242
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0024 0.0038 0.5144
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0011 0.0153
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0024 0.0038 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.2081 0.3894
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0052 0.0216 0.2885
Echinococcus granulosus serine protein kinase ATM 0.012 0.0653 0.0653
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Brugia malayi CXXC zinc finger family protein 0.0028 0.0063 0.0118
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.2081 0.3894
Loa Loa (eye worm) DOMON domain-containing protein 0.0052 0.0214 0.024
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0083
Plasmodium vivax ataxin-2 like protein, putative 0.002 0.0011 0.0153
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0134 0.0748 0.2901
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0418 0.2577 0.4822
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0134 0.0748 0.0838
Echinococcus multilocularis serine protein kinase ATM 0.012 0.0653 0.0653
Trypanosoma cruzi cytochrome P450, putative 0.0024 0.0038 0.0071
Schistosoma mansoni zinc finger protein 0.0021 0.0015 0.0015
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0301 0.1827 0.3419
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0011 0.0021
Brugia malayi jmjC domain containing protein 0.0038 0.0127 0.0238
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2577 0.4822
Echinococcus granulosus jumonji domain containing protein 0.004 0.0138 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0278 0.1676 0.3136
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0418 0.2577 0.4822
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0216 0.0216
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0182 0.0182
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0115 0.062 0.1262
Entamoeba histolytica hypothetical protein 0.0679 0.4265 0.798
Schistosoma mansoni hypothetical protein 0.0052 0.0216 0.0216
Onchocerca volvulus 0.0052 0.0216 0.1154
Loa Loa (eye worm) hypothetical protein 0.0269 0.1621 0.1817
Brugia malayi beta-lactamase family protein 0.003 0.0074 0.0138
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0024 0.0038 0.0341
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0074 0.0138
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0418 0.2577 1
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.003 0.0074 0.0138
Mycobacterium tuberculosis Conserved protein 0.003 0.0074 0.0663
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0024 0.0038 0.0341
Onchocerca volvulus 0.003 0.0074 0.0084
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0079 0.039 0.073
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.012 0.0653 0.0653
Onchocerca volvulus 0.003 0.0074 0.0084
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0052 0.0216 0.0404
Brugia malayi beta-lactamase 0.003 0.0074 0.0138
Loa Loa (eye worm) hypothetical protein 0.0052 0.0216 0.0242
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2577 0.4822
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0487 0.0487
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0134 0.0748 0.1399
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0301 0.1827 0.1827
Trypanosoma cruzi PAB1-binding protein , putative 0.002 0.0011 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0226 0.0422
Loa Loa (eye worm) hypothetical protein 0.0558 0.3482 0.3904
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0168 0.0965 0.1806
Loa Loa (eye worm) hypothetical protein 0.0038 0.0124 0.0139
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0168 0.0965 0.0965
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0558 0.3482 0.6516
Schistosoma mansoni cpg binding protein 0.0032 0.0085 0.0085
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0191 0.1117 0.4333
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0024 0.0038 0.0341
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0052 0.0216 0.2885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Schistosoma mansoni hypothetical protein 0.0029 0.0066 0.0066
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0024 0.0038 0.5144
Toxoplasma gondii FATC domain-containing protein 0.012 0.0653 0.133
Loa Loa (eye worm) cytochrome P450 family protein 0.0042 0.0152 0.017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0012 0.0013
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0066 0.0074
Toxoplasma gondii ABC1 family protein 0.003 0.0074 0.0151
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0965 0.1806
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0038 0.0071
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0024 0.0038 0.5144
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0418 0.2577 0.4822
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0024 0.0038 0.5144
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0052 0.0216 0.0216
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1393 0.8877 0.8877
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0846 0.5345 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.003 0.0074 0.0074
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0074 0.0074
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0024 0.0038 0.0341
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0216 0.0404
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0134 0.0748 1
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0024 0.0038 0.0341
Mycobacterium tuberculosis Probable hydrolase 0.003 0.0074 0.0663
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0134 0.0748 0.1399
Trichomonas vaginalis penicillin-binding protein, putative 0.003 0.0074 0.0138
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.5345 1
Loa Loa (eye worm) cytochrome P450 0.0024 0.0038 0.0043
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0066 0.0066
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0024 0.0038 0.5144
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0418 0.2577 0.4822
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0105 0.0561 0.0561
Loa Loa (eye worm) hypothetical protein 0.0105 0.0561 0.0628
Trichomonas vaginalis PIKK family atypical protein kinase 0.012 0.0653 0.1223
Brugia malayi Bromodomain containing protein 0.0038 0.0124 0.0231
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0024 0.0038 0.5144
Echinococcus multilocularis 0.0024 0.0038 0.0038
Echinococcus granulosus cytochrome P450 2K1 0.0024 0.0038 0.0038
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0134 0.0748 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0024 0.0038 0.5144
Trichomonas vaginalis conserved hypothetical protein 0.0115 0.062 0.1161
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0074 0.0138
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.1205 0.1351
Schistosoma mansoni hypothetical protein 0.0063 0.0285 0.0285
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0083
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0301 0.1827 0.3419
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0205 0.1206 0.468
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0024 0.0038 0.0341
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0134 0.0748 0.1399
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0024 0.0038 0.0341
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0038
Mycobacterium ulcerans beta-lactamase 0.003 0.0074 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0066 0.0066
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0561 0.1049
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0024 0.0038 0.0341
Leishmania major hypothetical protein, conserved 0.002 0.0011 0.0044
Leishmania major phosphatidylinositol 3-kinase, putative 0.0134 0.0748 0.2901
Toxoplasma gondii cytochrome p450 superfamily protein 0.0779 0.4914 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0074 0.0074
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0052 0.0216 0.2885
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.003 0.0074 0.0663
Entamoeba histolytica hypothetical protein 0.0052 0.0216 0.0404
Brugia malayi Cytochrome P450 family protein 0.0024 0.0038 0.0071
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0846 0.5345 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0264 0.1587 0.2969
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0024 0.0038 0.5144
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0074 0.0138
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0079 0.039 0.039
Mycobacterium tuberculosis Probable esterase LipL 0.003 0.0074 0.0663
Plasmodium vivax hypothetical protein, conserved 0.0052 0.0216 0.2885
Brugia malayi Cytochrome P450 family protein 0.0024 0.0038 0.0071
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0216 0.0439
Schistosoma mansoni hypothetical protein 0.0141 0.079 0.079
Schistosoma mansoni bromodomain containing protein 0.0064 0.0293 0.0293
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0216 0.0404
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0024 0.0038 0.0341
Schistosoma mansoni fkbp-rapamycin associated protein 0.0105 0.0561 0.0561
Trichomonas vaginalis PIKK family atypical protein kinase 0.0105 0.0561 0.1049
Schistosoma mansoni cpg binding protein 0.0028 0.0063 0.0063
Leishmania major cytochrome p450-like protein 0.0024 0.0038 0.0148
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0024 0.0038 0.5144
Giardia lamblia GTOR 0.0418 0.2577 0.9875
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0105 0.0561 0.1049
Trichomonas vaginalis PIKK family atypical protein kinase 0.0264 0.1587 0.2969
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0024 0.0038 0.5144
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0016 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0074 0.0074
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0216 0.0216
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0024 0.0038 0.0341
Loa Loa (eye worm) phosphatidylinositol kinase 0.0052 0.0216 0.0242
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0024 0.0038 0.5144
Mycobacterium tuberculosis Probable lipase LipE 0.003 0.0074 0.0663
Brugia malayi MH2 domain containing protein 0.011 0.0591 0.1105
Echinococcus multilocularis 0.0052 0.0216 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0063 0.0285 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0965 0.1806
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0068 0.0318 0.0357
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0168 0.0965 0.0965
Onchocerca volvulus 0.0052 0.0216 0.1154
Mycobacterium ulcerans lipase LipD 0.003 0.0074 1
Leishmania major cytochrome p450-like protein 0.0024 0.0038 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0083
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0134 0.0748 0.0748
Echinococcus granulosus peregrin 0.0031 0.0081 0.0081
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0052 0.0216 0.0837
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0066 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0052 0.0216 0.0404
Loa Loa (eye worm) hypothetical protein 0.0115 0.062 0.0695
Loa Loa (eye worm) hypothetical protein 0.0077 0.0375 0.042
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0079 0.039 0.039
Echinococcus multilocularis peregrin 0.0031 0.0081 0.0081
Mycobacterium ulcerans esterase/lipase LipP 0.003 0.0074 1
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0052 0.0216 0.0216
Echinococcus granulosus geminin 0.0141 0.079 0.079
Toxoplasma gondii target of rapamycin (TOR), putative 0.0321 0.1956 0.398
Leishmania major hypothetical protein, conserved 0.003 0.0074 0.0287
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.025 0.1492 0.2792
Entamoeba histolytica hypothetical protein 0.012 0.0653 0.1223
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0052 0.0216 0.0216
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0024 0.0038 0.5144
Brugia malayi jmjC domain containing protein 0.0094 0.0487 0.091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0355 0.2173 0.4065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.1551 0.2902
Mycobacterium leprae Probable lipase LipE 0.003 0.0074 0.2021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.1551 0.2902
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0105 0.0105
Schistosoma mansoni cpg binding protein 0.0032 0.0085 0.0085
Leishmania major phosphatidylinositol 4-kinase, putative 0.0052 0.0216 0.0837
Echinococcus multilocularis geminin 0.0141 0.079 0.079
Echinococcus granulosus beta LACTamase domain containing family member 0.003 0.0074 0.0074
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0024 0.0038 0.5144
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0024 0.0038 0.0341
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0063 0.0285 0.0285
Brugia malayi PHD-finger family protein 0.0029 0.0066 0.0123
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0191 0.1116 1
Loa Loa (eye worm) hypothetical protein 0.0269 0.1621 0.1817
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0418 0.2577 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0168 0.0965 0.1082
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0052 0.0216 0.0404
Mycobacterium leprae conserved hypothetical protein 0.003 0.0074 0.2021
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0134 0.0748 0.0748
Schistosoma mansoni dopamine-beta-monooxygenase 0.051 0.3176 0.3176
Trichomonas vaginalis PIKK family atypical protein kinase 0.0259 0.1551 0.2902
Loa Loa (eye worm) hypothetical protein 0.0047 0.0182 0.0204
Loa Loa (eye worm) hypothetical protein 0.0049 0.0198 0.0222
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0024 0.0038 0.0341
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0134 0.0748 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0794 0.501 0.9373
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0418 0.2577 1
Onchocerca volvulus 0.003 0.0074 0.0084
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0269 0.1621 0.3033
Trichomonas vaginalis esterase, putative 0.003 0.0074 0.0138
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0269 0.1621 0.3033
Trypanosoma brucei cytochrome P450, putative 0.0024 0.0038 0.0148
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0083
Trypanosoma brucei PAB1-binding protein , putative 0.002 0.0011 0.0044
Loa Loa (eye worm) phosphatidylinositol 3 0.0418 0.2577 0.2889
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0558 0.3482 0.3482
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0168 0.0965 0.1806
Brugia malayi PHD-finger family protein 0.0026 0.0049 0.0092
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0034 0.0034
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0063 0.0063
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0134 0.0748 0.1399
Brugia malayi DOMON domain containing protein 0.0052 0.0214 0.04
Echinococcus multilocularis cpg binding protein 0.0032 0.0085 0.0085
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0418 0.2577 1
Leishmania major phosphatidylinositol kinase, putative 0.0052 0.0216 0.0837
Plasmodium vivax SET domain protein, putative 0.003 0.0074 0.099
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0127 0.0127
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0079 0.039 0.039
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0137 0.0764 0.1429
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0079 0.039 0.039
Brugia malayi Bromodomain containing protein 0.0075 0.0367 0.0687
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0024 0.0038 0.0341
Entamoeba histolytica protein kinase rad3, putative 0.0105 0.0561 0.1049
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0024 0.0038 0.0341
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.0269 0.1621 0.1621
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.146 0.2731
Loa Loa (eye worm) phosphatidylinositol 3 0.025 0.1492 0.1673
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.059 0.3689 0.6903
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0846 0.5345 1
Brugia malayi Pre-SET motif family protein 0.0205 0.1205 0.2255
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0079 0.039 0.039
Schistosoma mansoni hypothetical protein 0.002 0.0012 0.0012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0274 0.0274
Echinococcus granulosus zinc finger protein 0.0021 0.0015 0.0015
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0066 0.0066
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0558 0.3482 0.3482
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0301 0.1827 0.3419
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0105 0.0561 0.1049
Loa Loa (eye worm) DOMON domain-containing protein 0.0052 0.0214 0.024
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0216 0.0216
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0024 0.0038 0.5144
Loa Loa (eye worm) hypothetical protein 0.0069 0.0329 0.0369
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0074 0.0138
Mycobacterium leprae conserved hypothetical protein 0.0052 0.0216 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0052 0.0216 0.0404
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0216 0.0439
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.012 0.0653 0.1223
Trichomonas vaginalis set domain proteins, putative 0.0233 0.1388 0.2596
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0083
Schistosoma mansoni peptidyl-glycine monooxygenase 0.0269 0.1621 0.1621
Plasmodium vivax hypothetical protein 0.0052 0.0216 0.2885
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0134 0.0748 0.1399
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0418 0.2577 0.4822
Loa Loa (eye worm) hypothetical protein 0.0288 0.1743 0.1954
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0038 0.0043
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0216 0.0404
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0168 0.0965 0.3745
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0079 0.039 0.0437
Loa Loa (eye worm) hypothetical protein 0.0029 0.0066 0.0074
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0079 0.039 0.039
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0105 0.0561 0.1049
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0052 0.0216 0.0216
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0418 0.2577 0.2577
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0134 0.0748 0.1399
Brugia malayi Bromodomain containing protein 0.0031 0.0081 0.0151
Loa Loa (eye worm) hypothetical protein 0.003 0.0074 0.0083
Echinococcus multilocularis zinc finger protein 0.0021 0.0015 0.0015
Onchocerca volvulus 0.0052 0.0214 0.1139
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0052 0.0216 0.2885
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0846 0.5345 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0391 0.2403 0.4496
Trichomonas vaginalis PIKK family atypical protein kinase 0.0245 0.1462 0.2735
Mycobacterium tuberculosis Conserved protein 0.003 0.0074 0.0663
Brugia malayi DOMON domain containing protein 0.0052 0.0214 0.04
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0127 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0965 0.1806
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0063 0.0285 0.0285
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0182 0.0182
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.003 0.0074 1
Brugia malayi FAT domain containing protein 0.0063 0.0285 0.0534
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0052 0.0216 0.0216
Loa Loa (eye worm) DOMON domain-containing protein 0.0052 0.0214 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.003 0.0074 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.002 0.0011 0.0153
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0134 0.0748 0.0748
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0074 0.0074
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.027 0.027
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.071 0.1328
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0052 0.0216 0.0404
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0024 0.0038 0.5144
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0216 0.0242
Onchocerca volvulus 0.0052 0.0214 0.1139
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0134 0.0748 0.2901
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0024 0.0038 0.5144
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0965 0.1806
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0134 0.0748 0.1399
Entamoeba histolytica hypothetical protein 0.0052 0.0216 0.0404
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0423 0.261 1
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0052 0.0216 0.0216
Brugia malayi Cytochrome P450 family protein 0.0042 0.0152 0.0284
Trichomonas vaginalis PIKK family atypical protein kinase 0.0168 0.0965 0.1806
Entamoeba histolytica hypothetical protein 0.0052 0.0216 0.0404
Giardia lamblia PHD finger protein 15 0.0029 0.0066 0.0252
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.2081 0.3894
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0024 0.0038 0.0148
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.0269 0.1621 0.1621
Loa Loa (eye worm) CYP4Cod1 0.0024 0.0038 0.0043
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0134 0.0748 0.0748
Schistosoma mansoni jumonji domain containing protein 0.0075 0.0362 0.0362
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0034 0.0034
Leishmania major phosphatidylinositol kinase related protein, putative 0.0066 0.0309 0.1197
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0134 0.0748 0.1522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.2081 0.3894
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0024 0.0038 0.0341
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.1567 1 1
Brugia malayi DOMON domain containing protein 0.0052 0.0214 0.04
Loa Loa (eye worm) transcription factor SMAD2 0.011 0.0591 0.0662
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0301 0.1827 0.3419
Loa Loa (eye worm) cytochrome P450 family protein 0.0024 0.0038 0.0043
Brugia malayi hypothetical protein 0.002 0.0011 0.0021
Schistosoma mansoni cytochrome P450 0.0024 0.0038 0.0038
Mycobacterium tuberculosis Probable conserved lipoprotein 0.003 0.0074 0.0663
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0034 0.0034
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0024 0.0038 0.0341
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0063 0.0071
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0219 0.1295 0.4963
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0248 0.0504
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0301 0.1827 0.709
Giardia lamblia Hypothetical protein 0.0052 0.0216 0.0827
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0024 0.0038 0.0071
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0846 0.5345 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0418 0.2577 0.4822
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0024 0.0038 0.0341
Trypanosoma cruzi target of rapamycin kinase 3 0.0341 0.2083 0.3897
Mycobacterium tuberculosis Conserved protein 0.003 0.0074 0.0663
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.003 0.0074 0.0663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0245 0.1462 0.2735
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.012 0.0653 0.1223
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0168 0.0965 0.3745
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.146 0.2731
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0134 0.0748 0.1522
Mycobacterium tuberculosis Probable lipase LipD 0.003 0.0074 0.0663
Loa Loa (eye worm) hypothetical protein 0.0044 0.0162 0.0181
Loa Loa (eye worm) phosphatidylinositol 3 0.14 0.892 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0226 0.0422
Trypanosoma cruzi hypothetical protein, conserved 0.003 0.0074 0.0138
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0418 0.2577 0.2577
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0301 0.1827 0.3419
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.004 0.0139 0.0156
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0024 0.0038 0.5144
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0052 0.0216 0.0439
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0418 0.2577 0.2577
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0024 0.0038 0.5144
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0138 0.0138
Trichomonas vaginalis PIKK family atypical protein kinase 0.0341 0.2081 0.3894
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0052 0.0216 0.0404
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.003 0.0074 0.0074
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0024 0.0038 0.0341
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0052 0.0216 0.0404
Brugia malayi Pre-SET motif family protein 0.003 0.0074 0.0139
Plasmodium vivax hypothetical protein, conserved 0.003 0.0074 0.0989
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0263 0.0294
Leishmania major hypothetical protein, conserved 0.0052 0.0216 0.0837
Brugia malayi Cytochrome P450 family protein 0.0024 0.0038 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0245 0.1462 0.2735
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0127 0.0142
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0024 0.0038 0.5144
Onchocerca volvulus 0.0233 0.1388 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0109 0.0109
Mycobacterium ulcerans hypothetical protein 0.003 0.0074 1
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0105 0.0561 0.0561
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0301 0.1827 0.3419
Brugia malayi beta-lactamase family protein 0.003 0.0074 0.0138
Plasmodium falciparum phd finger protein, putative 0.0029 0.0066 0.0878
Echinococcus multilocularis Zinc finger, PHD finger 0.0134 0.0748 0.0748
Schistosoma mansoni hypothetical protein 0.0141 0.079 0.079
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0024 0.0038 0.5144
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0168 0.0965 0.1806
Trypanosoma brucei hypothetical protein, conserved 0.003 0.0074 0.0287
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0679 0.4265 0.798
Toxoplasma gondii LsmAD domain-containing protein 0.002 0.0011 0.0023
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0134 0.0748 0.1399
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0341 0.2083 0.8082
Mycobacterium tuberculosis Conserved hypothetical protein 0.0052 0.0216 0.1934
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0168 0.0965 0.0965
Leishmania major phosphatidylinositol 3-kinase, putative 0.0168 0.0965 0.3745
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.059 0.3689 0.6903
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0168 0.0965 0.3745
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0066 0.0134
Loa Loa (eye worm) phosphatidylinositol 3 0.0052 0.0216 0.0242
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0321 0.1956 0.3659
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0066 0.0309 0.0577
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0024 0.0038 0.0148
Echinococcus granulosus cpg binding protein 0.0032 0.0085 0.0085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0079 0.039 0.039
Loa Loa (eye worm) beta-lactamase 0.003 0.0074 0.0083
Leishmania major hypothetical protein, unknown function 0.0052 0.0216 0.0837
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0487 0.0487
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0127 0.0127
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0052 0.0216 0.0837
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0721 0.4536 0.8487
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0846 0.5345 1
Onchocerca volvulus 0.003 0.0074 0.0084
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.003 0.0074 0.0083
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0052 0.0216 0.0404
Trichomonas vaginalis PIKK family atypical protein kinase 0.0244 0.146 0.2731
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0024 0.0038 0.0071
Brugia malayi cytochrome P450 0.0024 0.0038 0.0071
Schistosoma mansoni peptidylglycine monooxygenase 0.0269 0.1621 0.1621
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0068 0.0318 0.0596
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.027 0.027
Leishmania major cytochrome p450-like protein 0.0024 0.0038 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0066 0.0878
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0341 0.2083 0.8082
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.1567 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0109 0.0109
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0052 0.0216 0.0216
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0182 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0287 0.1736 0.3248

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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