Detailed information for compound 1658896

Basic information

Technical information
  • TDR Targets ID: 1658896
  • Name: (3S,5R,8R,9S,10S,13R,14S,17R)-17-[(E,3E)-3-me thoxyiminoprop-1-enyl]-10,13-dimethyl-1,2,3,4 ,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclo penta[a]phenanthrene-3,14-diol
  • MW: 375.545 | Formula: C23H37NO3
  • H donors: 2 H acceptors: 2 LogP: 4.16 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CO/N=C/C=C/[C@H]1CC[C@]2([C@]1(C)CC[C@H]1[C@H]2CC[C@H]2[C@]1(C)CC[C@@H](C2)O)O
  • InChi: 1S/C23H37NO3/c1-21-11-9-18(25)15-17(21)6-7-20-19(21)10-12-22(2)16(5-4-14-24-27-3)8-13-23(20,22)26/h4-5,14,16-20,25-26H,6-13,15H2,1-3H3/b5-4+,24-14+/t16-,17+,18-,19-,20+,21-,22+,23-/m0/s1
  • InChiKey: MRNITUAYDRGKCQ-RGBJVUNTSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase, Na+/K+ transporting, beta 1 polypeptide Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Onchocerca volvulus Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum Sodium/potassium-transporting ATPase subunit beta-1, putative Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium transporting ATPase subunit Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma japonicum ko:K01540 Na+/K+-exchanging ATPase beta subunit [EC3.6.3.9B], putative Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus sodium:potassium transporting ATPase subunit Get druggable targets OG5_131864 All targets in OG5_131864
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni transmemberane protein Get druggable targets OG5_131864 All targets in OG5_131864
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus multilocularis nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131864 All targets in OG5_131864
Echinococcus granulosus nervana 2 Get druggable targets OG5_131864 All targets in OG5_131864
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni microtubule-associated protein tau 0.1363 1 1
Echinococcus multilocularis nervana 2 0.029 0.2003 0.1989
Brugia malayi Membrane calcium atpase protein 3 0.0041 0.0149 0.0224
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0081 0.0447 0.0674
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0057 0.0268 0.0559
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0202 0.0304
Schistosoma mansoni ATPase 0.0042 0.0155 0.0141
Schistosoma mansoni sodium / potassium ATPase beta chain 0.0241 0.1644 0.1632
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0026 0.0392
Schistosoma mansoni retinoic acid receptor RXR 0.0091 0.052 0.0506
Echinococcus multilocularis thyroid hormone receptor alpha 0.0091 0.052 0.0503
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0099 0.0585 0.0568
Treponema pallidum fructose-bisphosphate aldolase 0.1278 0.9364 1
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.0643 0.0625
Brugia malayi bZIP transcription factor family protein 0.0084 0.0471 0.071
Schistosoma mansoni hypothetical protein 0.0099 0.0585 0.0571
Mycobacterium ulcerans pyruvate kinase 0.004 0.0143 0.028
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0044 0.0174 0.0156
Brugia malayi photoreceptor-specific nuclear receptor 0.0091 0.052 0.0785
Schistosoma mansoni survival motor neuron protein 0.0058 0.0276 0.0262
Schistosoma mansoni calcium-transporting atpase 2 (atpase 2) 0.0041 0.0149 0.0135
Echinococcus granulosus Ca2 transporting ATPase plasma membrane 0.0041 0.0149 0.0131
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0064 0.0319 0.0673
Brugia malayi cytochrome P450 0.0029 0.0064 0.0096
Mycobacterium leprae Conserved hypothetical protein 0.0029 0.0064 0.0101
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.029 0.2003 0.1992
Schistosoma mansoni coup transcription factor 0.0091 0.052 0.0506
Brugia malayi Glycosyl hydrolases family 31 protein 0.0036 0.0111 0.0166
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0079 0.0079
Onchocerca volvulus 0.1034 0.7551 1
Toxoplasma gondii P-type ATPase4, putative 0.0044 0.0174 0.1352
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0051 0.0226 0.0464
Brugia malayi hypothetical protein 0.0048 0.0202 0.0304
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0091 0.052 0.0665
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0909 0.6616 1
Onchocerca volvulus 0.0169 0.1106 0.1443
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0019 0.0003
Leishmania major cytochrome p450-like protein 0.0029 0.0064 0.0369
Schistosoma mansoni hypothetical protein 0.0081 0.0447 0.0434
Echinococcus granulosus jun protein 0.0084 0.0471 0.0454
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0111 0.0118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.052 0.0503
Echinococcus granulosus phd:f box containing protein 0.0043 0.017 0.0152
Giardia lamblia Potassium-transporting ATPase alpha chain 1 0.0085 0.0479 0.0493
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0028
Loa Loa (eye worm) hypothetical protein 0.0181 0.1198 0.1809
Schistosoma mansoni hypothetical protein 0.0029 0.0059 0.0045
Echinococcus multilocularis jumonji domain containing 1A 0.0043 0.017 0.0152
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0034 0.005
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.104 0.1571
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0029 0.0064 0.0104
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.052 0.0785
Mycobacterium leprae putative cytochrome p450 0.0029 0.0064 0.0101
Plasmodium falciparum non-SERCA-type Ca2+ -transporting P-ATPase 0.0044 0.0174 0.7343
Schistosoma mansoni apoptosis regulator bax 0.0099 0.0585 0.0571
Loa Loa (eye worm) nuclear hormone receptor 0.0043 0.0164 0.0246
Schistosoma mansoni nuclear receptor 0.0043 0.0164 0.015
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0643 0.0686
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0028
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0061 0.006
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0043 0.0164 0.0146
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0025 0.003 0.0028
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0019 0.0028
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0041 0.0149 0.2306
Onchocerca volvulus 0.0043 0.0164 0.0192
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.017 0.0255
Echinococcus multilocularis cpg binding protein 0.0036 0.0115 0.0097
Plasmodium vivax calcium-transporting ATPase, putative 0.0044 0.0174 0.1814
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.0113
Trichomonas vaginalis sucrase-isomaltase, putative 0.0036 0.0111 0.0113
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0077 0.0416 0.0889
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0091 0.052 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.052 0.0785
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0471 0.1011
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0041 0.0149 0.0135
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0079 0.0487
Echinococcus multilocularis sterol regulatory element binding protein 0.0084 0.047 0.0453
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0029 0.0064 0.0104
Toxoplasma gondii histone lysine methyltransferase SET1 0.007 0.0364 0.2833
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0043 0.0164 0.0146
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.003 0.0231
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0079 0.0434 0.0655
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Giardia lamblia Methyltransferase like 2 0.0024 0.0023 0.0005
Echinococcus multilocularis nervana 2 0.029 0.2003 0.1989
Echinococcus multilocularis jun protein 0.0084 0.0471 0.0454
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.0276 0.0416
Echinococcus granulosus dnaJ subfamily B 0.0487 0.3471 0.3459
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0304
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0048 0.0202 0.0304
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative 0.0042 0.0155 0.2197
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0597 0.0583
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.003 0.02
Onchocerca volvulus 0.0145 0.0923 0.12
Brugia malayi jmjC domain containing protein 0.0165 0.1075 0.1624
Mycobacterium ulcerans aldehyde dehydrogenase 0.0193 0.1281 0.2821
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0193 0.1281 0.1266
Echinococcus multilocularis peregrin 0.0029 0.0059 0.0042
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0522
Echinococcus granulosus Niemann Pick C1 protein 0.0279 0.1925 0.191
Leishmania major cytochrome p450-like protein 0.0029 0.0064 0.0369
Leishmania major P-type H -ATPase, putative 0.0024 0.0026 0.0064
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0044 0.0174 0.0156
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0019 0.0003
Echinococcus granulosus jumonji domain containing 1A 0.0043 0.017 0.0152
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0029 0.0064 0.0104
Brugia malayi nuclear receptor NHR-88 0.0043 0.0164 0.0246
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0079 0.0434 0.093
Loa Loa (eye worm) pyruvate kinase 0.004 0.0143 0.0216
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.016
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0025 0.003 0.0025
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0073 0.039 0.0588
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0029 0.0064 0.0104
Mycobacterium ulcerans polyketide synthase MbtD 0.0024 0.0027 0.0019
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.029 0.2003 0.1989
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0081 0.0447 0.0957
Loa Loa (eye worm) hypothetical protein 0.0042 0.0155 0.0233
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Echinococcus multilocularis microtubule associated protein 2 0.1363 1 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.017 0.0255
Mycobacterium ulcerans thioesterase TesA 0.0066 0.0336 0.0711
Echinococcus multilocularis pyruvate kinase 0.0032 0.0081 0.0063
Trypanosoma cruzi calcium motive p-type ATPase, putative 0.0041 0.0149 0.2306
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0065 0.0327 0.069
Brugia malayi 6-phosphofructokinase 0.0107 0.0644 0.0972
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0048 0.0202 0.0188
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0241 0.1644 0.1629
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0059 0.0042
Schistosoma mansoni cpg binding protein 0.0036 0.0115 0.01
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0099 0.0585 0.0568
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0434 0.093
Echinococcus granulosus histone lysine methyltransferase setb 0.0131 0.0822 0.0805
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0434 0.093
Loa Loa (eye worm) hypothetical protein 0.0088 0.0504 0.0761
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0029 0.0064 0.0104
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0019 0.0003
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0091 0.052 0.0785
Loa Loa (eye worm) jmjC domain-containing protein 0.0165 0.1075 0.1624
Schistosoma mansoni thyroid hormone receptor 0.0091 0.052 0.0506
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0029 0.0064 0.0104
Trypanosoma brucei calcium-transporting ATPase, putative 0.0025 0.0035 0.027
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.0543 0.3893 0.5884
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0048 0.0202 0.0184
Schistosoma mansoni protein phosphatase 2C 0.0043 0.017 0.0155
Schistosoma mansoni DNA polymerase eta 0.0023 0.0018 0.0004
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.052 0.0506
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.0113
Echinococcus multilocularis FTZ F1 alpha 0.0091 0.052 0.0503
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0643 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0192 0.0289
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0019 0.0028
Plasmodium falciparum pyruvate kinase 0.004 0.0143 0.5784
Schistosoma mansoni alpha-glucosidase 0.0138 0.0874 0.0861
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0029 0.0064 0.0746
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0027 0.0048 0.0067
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0051 0.0226 0.1758
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0101 0.0597 0.058
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0164 0.0146
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0029 0.0064 0.0104
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0088 0.0504 0.0761
Trichomonas vaginalis cation-transporting ATPase, putative 0.0042 0.0155 0.016
Trichomonas vaginalis cation-transporting ATPase, putative 0.0042 0.0155 0.016
Schistosoma mansoni hypothetical protein 0.0539 0.3863 0.3854
Loa Loa (eye worm) hypothetical protein 0.0047 0.0194 0.0293
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0031 0.0079 0.0079
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0101 0.0597 0.058
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0064 0.0992
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0043 0.0164 0.0146
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0036 0.0111 0.0858
Onchocerca volvulus Protein ultraspiracle homolog 0.0091 0.052 0.0665
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0023 0.0019 0.002
Loa Loa (eye worm) cytochrome P450 family protein 0.0109 0.0655 0.0988
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0044 0.0174 0.0156
Schistosoma mansoni jumonji/arid domain-containing protein 0.0165 0.1075 0.1062
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0091 0.052 0.0506
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0029 0.0064 0.0104
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0716 0.07
Trypanosoma brucei hypothetical protein, conserved 0.0051 0.0226 0.3329
Schistosoma mansoni lipoxygenase 0.0082 0.0454 0.0441
Trypanosoma brucei P-type H+-ATPase, putative 0.0024 0.0026 0.0129
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0131 0.0822 0.0805
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0091 0.052 0.0785
Loa Loa (eye worm) hypothetical protein 0.0103 0.061 0.0921
Mycobacterium leprae Probable pyruvate kinase PykA 0.004 0.0143 0.0277
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0061 0.1561
Echinococcus multilocularis ecdysone induced protein 78C 0.0091 0.052 0.0503
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0079 0.0079
Echinococcus multilocularis Niemann Pick C1 protein 0.0279 0.1925 0.191
Loa Loa (eye worm) glutaminase 0.0325 0.2268 0.3428
Onchocerca volvulus 0.0241 0.1644 0.2157
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0029 0.0064 0.0104
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0061 0.006
Schistosoma mansoni phd/f-box containing protein 0.0043 0.017 0.0155
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0222 0.1502 0.1487
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.0698 0.0685
Mycobacterium ulcerans cation-transporter ATPase I CtpI 0.0026 0.0041 0.0052
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0051 0.0226 0.5
Echinococcus granulosus Niemann Pick C1 protein 0.0195 0.13 0.1285
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0029 0.0064 0.0104
Brugia malayi Pre-SET motif family protein 0.0909 0.6616 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1278 0.9364 1
Echinococcus multilocularis calcium transporting atpase 0.0041 0.0149 0.0131
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0193 0.1281 0.2821
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0077 0.0416 0.0889
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0137 0.087 0.0853
Loa Loa (eye worm) glutaminase 2 0.0325 0.2268 0.3428
Echinococcus granulosus aryl hydrocarbon receptor 0.017 0.1111 0.1095
Brugia malayi Heterochromatin protein 1 0.0084 0.0468 0.0706
Schistosoma mansoni pyruvate kinase 0.004 0.0143 0.0129
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.015 0.0961 0.1452
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0029 0.0064 0.0104
Loa Loa (eye worm) glutathione reductase 0.0047 0.0192 0.0289
Brugia malayi Steroid receptor seven-up type 2 0.0091 0.052 0.0785
Loa Loa (eye worm) phosphofructokinase 0.0107 0.0643 0.097
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0091 0.052 0.0785
Brugia malayi nuclear hormone receptor 0.0091 0.052 0.0785
Mycobacterium ulcerans glutaminase 0.0325 0.2268 0.5026
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0101 0.0597 0.058
Brugia malayi indoleamine 2,3-dioxygenase 0.0543 0.3893 0.5884
Brugia malayi Niemann-Pick C1 protein precursor 0.0195 0.13 0.1965
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0058 0.0087
Brugia malayi nuclear receptor NHR-88 0.0091 0.052 0.0785
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.0241 0.1644 0.1632
Mycobacterium ulcerans fatty acid synthase Fas 0.0025 0.003 0.0028
Echinococcus granulosus nervana 2 0.0241 0.1644 0.1629
Entamoeba histolytica acyl-CoA synthetase, putative 0.0031 0.0079 0.0084
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0084 0.0471 0.1011
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0029 0.0064 0.0104
Schistosoma mansoni RAR-like nuclear receptor 0.0091 0.052 0.0506
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Echinococcus granulosus sterol regulatory element binding protein 0.0084 0.047 0.0453
Echinococcus multilocularis lamin dm0 0.0053 0.0242 0.0225
Entamoeba histolytica hypothetical protein 0.0114 0.0698 0.0746
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0822 0.0808
Loa Loa (eye worm) hypothetical protein 0.0195 0.13 0.1965
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0143 0.0125
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0091 0.052 0.0785
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0029 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.104 0.1024
Trypanosoma brucei P-type H+-ATPase, putative 0.0024 0.0026 0.0129
Toxoplasma gondii type I fatty acid synthase, putative 0.0085 0.0478 0.3726
Schistosoma mansoni hypothetical protein 0.0081 0.0447 0.0434
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0643 0.0629
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.104 0.1571
Brugia malayi CXXC zinc finger family protein 0.0034 0.01 0.015
Echinococcus multilocularis Niemann Pick C1 protein 0.0195 0.13 0.1285
Loa Loa (eye worm) hypothetical protein 0.029 0.2003 0.3027
Schistosoma mansoni cpg binding protein 0.0034 0.01 0.0086
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0023 0.0019 0.0027
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0099 0.0585 0.0883
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0042 0.0155 0.016
Echinococcus multilocularis protein dispatched 1 0.0096 0.0558 0.0541
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0019 0.0021
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.0643 0.4945
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0091 0.052 0.0785
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0725 0.1576
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0036 0.0111 0.0166
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0643 0.0681
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0043 0.0164 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0091 0.052 0.0785
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 0.0042 0.0155 0.2197
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0043 0.017 0.1319
Brugia malayi hypothetical protein 0.018 0.1183 0.1788
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0111 0.1712
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0198 0.1323 0.131
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.0698 0.0682
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0032 0.0084 0.0126
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0079 0.0079
Brugia malayi bHLH-PAS transcription factor 0.0089 0.0511 0.0772
Trypanosoma brucei pyruvate kinase 1 0.004 0.0143 0.201
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0042 0.0155 0.1206
Onchocerca volvulus Fatty acid synthase homolog 0.0142 0.0907 0.1178
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0029 0.0064 0.0104
Brugia malayi Pyruvate kinase, M2 isozyme 0.004 0.0143 0.0216
Echinococcus granulosus lysine specific demethylase 5A 0.0165 0.1075 0.1059
Echinococcus granulosus Na:K ATPase alpha subunit 0.0085 0.0479 0.0462
Loa Loa (eye worm) DR-78 0.0043 0.0164 0.0246
Echinococcus granulosus pyruvate kinase 0.004 0.0143 0.0126
Mycobacterium ulcerans metal cation-transporting p-type ATPase F, CtpF 0.0044 0.0174 0.0348
Loa Loa (eye worm) CYP4Cod1 0.0049 0.0207 0.0312
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0037 0.0019
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0091 0.052 0.0503
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Schistosoma mansoni jumonji domain containing protein 0.0203 0.1358 0.1346
Echinococcus granulosus intermediate filament protein 0.0053 0.0242 0.0225
Schistosoma mansoni intermediate filament proteins 0.0053 0.0242 0.0228
Schistosoma mansoni nuclear receptor 0.0043 0.0164 0.015
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0434 0.093
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0059 0.0457
Onchocerca volvulus 0.0066 0.0337 0.0421
Loa Loa (eye worm) apoptosis regulator protein 0.0099 0.0585 0.0883
Onchocerca volvulus 0.0034 0.01 0.0107
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane 0.0041 0.0149 0.0131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Brugia malayi Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0041 0.0149 0.0224
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0137 0.087 0.1902
Brugia malayi hypothetical protein 0.0025 0.003 0.0045
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0029 0.0064 0.0992
Trypanosoma brucei trypanothione reductase 0.0047 0.0192 0.2792
Trichomonas vaginalis cation-transporting ATPase, putative 0.0024 0.0026 0.0022
Echinococcus granulosus neutral alpha glucosidase AB 0.0036 0.0111 0.0093
Loa Loa (eye worm) nuclear receptor NHR-67 0.0043 0.0164 0.0246
Loa Loa (eye worm) hypothetical protein 0.0044 0.0176 0.0264
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0029 0.0064 0.0104
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0029 0.0064 0.0104
Trypanosoma brucei pyruvate kinase 1, putative 0.004 0.0143 0.201
Leishmania major protein kinase, putative 0.0031 0.0079 0.0487
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0822 0.0808
Onchocerca volvulus 0.029 0.2003 0.2634
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0029 0.0064 0.0104
Echinococcus multilocularis survival motor neuron protein 1 0.0283 0.1957 0.1943
Schistosoma mansoni jumonji domain containing protein 0.0043 0.017 0.0155
Schistosoma mansoni lipoxygenase 0.0117 0.0716 0.0703
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0052 0.0235 0.0484
Trypanosoma cruzi calcium-transporting ATPase, putative 0.0025 0.0035 0.0529
Schistosoma mansoni hypothetical protein 0.0114 0.0698 0.0685
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0077 0.0421 0.0407
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0045 0.0184 0.0167
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0026
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0044 0.0174 0.1352
Plasmodium falciparum calcium-transporting ATPase 0.0041 0.0149 0.6055
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.033 0.2467
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0029 0.0064 0.0104
Schistosoma mansoni hypothetical protein 0.0081 0.0447 0.0434
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0045 0.018 0.0362
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0088 0.0504 0.049
Mycobacterium leprae Polyketide synthase Pks13 0.0118 0.0725 0.1577
Echinococcus granulosus peregrin 0.0029 0.0059 0.0042
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0061 0.0065
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0043 0.0164 0.0146
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Brugia malayi nuclear receptor RXR 0.0048 0.0202 0.0304
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0052 0.0235 0.0481
Loa Loa (eye worm) hypothetical protein 0.0099 0.0585 0.0883
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Giardia lamblia PHD finger protein 15 0.0029 0.0059 0.0044
Trichomonas vaginalis maltase-glucoamylase, putative 0.0036 0.0111 0.0113
Loa Loa (eye worm) hypothetical protein 0.0138 0.0877 0.1325
Loa Loa (eye worm) hypothetical protein 0.0082 0.0454 0.0685
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0084 0.0471 0.1008
Echinococcus multilocularis lysine specific demethylase 5A 0.0163 0.1061 0.1045
Schistosoma mansoni sodium/potassium-dependent atpase beta subunit 0.029 0.2003 0.1992
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.016
Trypanosoma brucei Putative Phosphatase/Protein of unknown function DUF89, putative 0.0054 0.0245 0.3631
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0031 0.0079 0.0079
Brugia malayi nuclear hormone receptor 0.0043 0.0164 0.0246
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0192 0.2984
Leishmania major alpha glucosidase II subunit, putative 0.0036 0.0111 0.0734
Echinococcus multilocularis dnaJ subfamily B 0.0487 0.3471 0.3459
Echinococcus granulosus lamin dm0 0.0053 0.0242 0.0225
Leishmania major P-type ATPase, putative 0.0041 0.0149 0.1036
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0287 0.0433
Echinococcus granulosus calcium transporting atpase 0.0041 0.0149 0.0131
Brugia malayi Probable calcium-transporting ATPase KIAA0703 0.0025 0.0035 0.0051
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0029 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Loa Loa (eye worm) calcium ATPase 0.0023 0.0019 0.0027
Loa Loa (eye worm) hypothetical protein 0.0169 0.1106 0.1671
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.0543 0.3893 0.3882
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.1654 0.2499
Entamoeba histolytica hypothetical protein 0.0051 0.0226 0.0241
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.0543 0.3893 0.3882
Entamoeba histolytica hypothetical protein 0.0114 0.0698 0.0746
Schistosoma mansoni phosphatidylserine receptor 0.0043 0.017 0.0155
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0143 0.0148
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0084 0.0471 0.1011
Brugia malayi Thioredoxin reductase 0.0047 0.0192 0.0289
Loa Loa (eye worm) hypothetical protein 0.0283 0.1957 0.2957
Loa Loa (eye worm) fatty acid synthase 0.0078 0.0426 0.0643
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0181 0.1198 0.1809
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.052 0.0785
Echinococcus granulosus single minded 2 0.0089 0.0511 0.0494
Loa Loa (eye worm) intermediate filament protein 0.0053 0.0242 0.0365
Plasmodium vivax P-type ATPase4, putative 0.0044 0.0174 0.1814
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0018 0.0014
Plasmodium falciparum phd finger protein, putative 0.0029 0.0059 0.1481
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0043 0.0164 0.015
Loa Loa (eye worm) hypothetical protein 0.0028 0.0053 0.0079
Mycobacterium leprae Probable polyketide synthase Pks1 0.0084 0.0471 0.1008
Echinococcus granulosus nuclear receptor nhr 48 0.0043 0.0164 0.0146
Schistosoma mansoni methyltransferase-related 0.0024 0.0023 0.0009
Loa Loa (eye worm) hypothetical protein 0.0084 0.047 0.0709
Onchocerca volvulus 0.0043 0.0164 0.0192
Loa Loa (eye worm) E1-E2 ATPase 0.0024 0.0026 0.0038
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0045 0.0184 0.0167
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0636 0.1381
Brugia malayi chromobox protein homolog 3 0.0047 0.0194 0.0293
Trichomonas vaginalis adenylate cyclase, putative 0.0031 0.0079 0.0079
Trichomonas vaginalis set domain proteins, putative 0.1034 0.7551 0.8063
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.004 0.0143 0.028
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0041 0.0149 0.0135
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0029 0.0064 0.0104
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0036 0.0111 0.0118
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0058 0.0087
Plasmodium falciparum thioredoxin reductase 0.0047 0.0192 0.8284
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.033 0.0352
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0061 0.006
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0044 0.0174 0.0156
Plasmodium vivax SET domain protein, putative 0.0131 0.0822 1
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0042 0.0155 0.0138
Brugia malayi jmjC domain containing protein 0.0043 0.017 0.0255
Schistosoma mansoni hypothetical protein 0.0543 0.3893 0.3885
Leishmania major P-type H -ATPase, putative 0.0024 0.0026 0.0064
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.0113
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0061 0.0386
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0241 0.1644 0.1629
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0091 0.052 0.0503
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0091 0.052 0.0785
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0042 0.0155 0.0138
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.0079 0.1225
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0042 0.0155 0.1087
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0053 0.0242 0.0365
Echinococcus granulosus thyroid hormone receptor alpha 0.0043 0.0164 0.0146
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0143 0.2223
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0207 0.3212
Schistosoma mansoni zinc finger protein 0.0043 0.0164 0.015
Echinococcus multilocularis geminin 0.0539 0.3863 0.3852
Loa Loa (eye worm) hypothetical protein 0.0023 0.0019 0.0028
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0091 0.052 0.0503
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0079 0.0434 0.093
Echinococcus granulosus nervana 2 0.029 0.2003 0.1989
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0031 0.0079 0.1121
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.0079 0.1225
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0032 0.0084 0.2746
Schistosoma mansoni aldehyde dehydrogenase 0.0193 0.1281 0.1269
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0051 0.0226 0.0464
Loa Loa (eye worm) hypothetical protein 0.0062 0.0305 0.046
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0079 0.0434 0.093
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0725 0.1579
Mycobacterium tuberculosis Probable reductase 0.0106 0.0636 0.1381
Schistosoma mansoni chromobox protein 0.0084 0.0468 0.0454
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0643 0.0686
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0304
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0029 0.0064 0.0104
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0061 0.0386
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0111 0.0113
Schistosoma mansoni hypothetical protein 0.0099 0.0585 0.0571
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0131 0.0822 0.0805
Brugia malayi conserved hypotetical protein 0.0043 0.0164 0.0246
Brugia malayi Pyruvate kinase, muscle isozyme 0.004 0.0143 0.0216
Chlamydia trachomatis pyruvate kinase 0.004 0.0143 0.5004
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0029 0.0064 0.0104
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0164 0.0246
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.0643 0.0626
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.0643 0.1395
Echinococcus multilocularis nervana 2 0.0241 0.1644 0.1629
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0192 0.0389
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0029 0.0064 0.0104
Brugia malayi orphan nuclear receptor NR2E1 0.0043 0.0164 0.0246
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0043 0.0164 0.0246
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0143 0.0165
Entamoeba histolytica hypothetical protein 0.0114 0.0698 0.0746
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0091 0.052 0.0785
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.017 0.0255
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0064 0.0319 0.0673
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.0079 0.0079
Toxoplasma gondii aldehyde dehydrogenase 0.0193 0.1281 1
Schistosoma mansoni hypothetical protein 0.0099 0.0585 0.0571
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0061 0.006
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0043 0.0164 0.0246
Echinococcus multilocularis chromobox protein 1 0.0084 0.0468 0.0451
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Loa Loa (eye worm) pyruvate kinase 0.004 0.0143 0.0216
Schistosoma mansoni chromobox protein 0.0084 0.0468 0.0454
Giardia lamblia Fructose-bisphosphate aldolase 0.1278 0.9364 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.0113
Onchocerca volvulus 0.0181 0.1198 0.1564
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 0.0042 0.0155 0.2197
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0137 0.087 0.1313
Echinococcus multilocularis transfer RNA-Lys 0.0089 0.0511 0.0494
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0029 0.0064 0.0104
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0048 0.0202 0.0188
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0055
Schistosoma mansoni transmemberane protein 0.029 0.2003 0.1992
Leishmania major pyruvate kinase 0.004 0.0143 0.0994
Echinococcus multilocularis sodium:potassium transporting ATPase subunit 0.029 0.2003 0.1989
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.0643 0.1395
Mycobacterium leprae Possible regulatory protein 0.0031 0.0079 0.0134
Mycobacterium ulcerans Type I modular polyketide synthase 0.0079 0.0434 0.093
Brugia malayi jmjC domain containing protein 0.0043 0.017 0.0255
Echinococcus multilocularis pyruvate kinase 0.004 0.0143 0.0126
Toxoplasma gondii P-type ATPase PMA1 0.0024 0.0026 0.0196
Schistosoma mansoni jumonji/arid domain-containing protein 0.0165 0.1075 0.1062
Toxoplasma gondii pyruvate kinase PyK1 0.004 0.0143 0.1114
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0048 0.0202 0.0184
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.017 0.2631
Trichomonas vaginalis pyruvate kinase, putative 0.004 0.0143 0.0148
Echinococcus granulosus survival motor neuron protein 1 0.0283 0.1957 0.1943
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0029 0.0064 0.0104
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0126 0.0108
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0716 0.07
Loa Loa (eye worm) hypothetical protein 0.0044 0.0175 0.0264
Brugia malayi intermediate filament protein 0.0053 0.0242 0.0365
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0143 0.0165
Loa Loa (eye worm) hypothetical protein 0.0138 0.0873 0.1318
Mycobacterium ulcerans aldehyde dehydrogenase 0.0193 0.1281 0.2821
Loa Loa (eye worm) pyruvate kinase-PB 0.0028 0.0053 0.0079
Brugia malayi tailless protein 0.0043 0.0164 0.0246
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.033 0.499
Echinococcus multilocularis Na+:K+ ATPase alpha subunit 0.0085 0.0479 0.0462
Echinococcus multilocularis 0.0029 0.0064 0.0047
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0597 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.047 0.0497
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0207 0.0312
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0255
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0192 0.0175
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0029 0.0064 0.0369
Trichomonas vaginalis chromobox protein, putative 0.005 0.0221 0.023
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0365
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0019 0.0003
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0193 0.1281 1
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0059 0.0366
Brugia malayi hypothetical protein 0.0283 0.1957 0.2957
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0636 0.1378
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1278 0.9364 1
Schistosoma mansoni hypothetical protein 0.0487 0.3471 0.3461
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.0166
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0084 0.0678
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0091 0.052 0.0785
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0099 0.0585 0.0568
Echinococcus multilocularis expressed protein 0.0367 0.2582 0.2569
Onchocerca volvulus Bile acid receptor homolog 0.0091 0.052 0.0665
Echinococcus granulosus sodium:potassium transporting ATPase subunit 0.029 0.2003 0.1989
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0019 0.0028
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0091 0.052 0.0503
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0054 0.0245 0.3801
Mycobacterium ulcerans polyketide synthase 0.0084 0.0471 0.1011
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Onchocerca volvulus Alhambra homolog 0.0029 0.0059 0.0053
Schistosoma mansoni aryl hydrocarbon receptor 0.0259 0.1777 0.1765
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0032 0.0084 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0194 0.0202
Brugia malayi nuclear receptor RXR 0.0043 0.0164 0.0246
Trypanosoma brucei glucosidase, putative 0.0036 0.0111 0.1485
Leishmania major trypanothione reductase 0.0047 0.0192 0.138
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0131 0.0822 0.641
Leishmania major phosphopantetheinyl transferase-like protein 0.0051 0.0226 0.1646
Onchocerca volvulus Heterochromatin protein 1 homolog 0.005 0.0221 0.0267
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.033 0.0497
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0084 0.0471 0.1008
Brugia malayi Cytochrome P450 family protein 0.0029 0.0064 0.0096
Trichomonas vaginalis chromobox protein, putative 0.005 0.0221 0.023
Echinococcus granulosus pyruvate kinase 0.004 0.0143 0.0126
Schistosoma mansoni aldehyde dehydrogenase 0.0193 0.1281 0.1269
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0636 0.1381
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0073 0.039 0.0588
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0045
Brugia malayi Cytochrome P450 family protein 0.0049 0.0207 0.0312
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.003 0.0462
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.033 0.0497
Schistosoma mansoni ATPase 0.0042 0.0155 0.0141
Onchocerca volvulus 0.0036 0.011 0.0121
Echinococcus multilocularis lysine specific demethylase 6a 0.0043 0.017 0.0152
Echinococcus granulosus JmjC domain containing protein 4 0.0043 0.017 0.0152
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0597 0.0583
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0164 0.015
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0725 0.1579
Toxoplasma gondii melibiase subfamily protein 0.0101 0.0597 0.4653
Loa Loa (eye worm) hypothetical protein 0.029 0.2003 0.3027
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0019 0.0003
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0164 0.0192
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0138 0.0873 0.1318
Brugia malayi hypothetical protein 0.0066 0.0337 0.0508
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.095 0.1434
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.0643 0.0686
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0044
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0018 0.0026
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0304
Echinococcus multilocularis plasma membrane calcium transporting ATPase 0.0041 0.0149 0.0131
Trichomonas vaginalis alpha-glucosidase, putative 0.0036 0.0111 0.0113
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0137 0.087 0.6743
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0091 0.052 0.0785
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.0643 0.0626
Brugia malayi nuclear receptor NHR-67 0.0043 0.0164 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0079 0.0079
Schistosoma mansoni alpha-glucosidase 0.0138 0.0874 0.0861
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0091 0.052 0.0503
Toxoplasma gondii thioredoxin reductase 0.0047 0.0192 0.1496
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0181 0.1198 0.1185
Mycobacterium ulcerans metal cation transporter p-type ATPase a 0.0086 0.0485 0.1044
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0042 0.0155 0.2406
Brugia malayi phosphofructokinase 0.0107 0.0643 0.097
Trichomonas vaginalis cation-transporting ATPase, putative 0.0042 0.0155 0.016
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.052 0.0785
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.003 0.0462
Mycobacterium ulcerans short-chain dehydrogenase 0.0026 0.0036 0.0041
Loa Loa (eye worm) hypothetical protein 0.018 0.1183 0.1788
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0061 0.047
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0029 0.0064 0.0104
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0192 0.2046
Brugia malayi ecdysone receptor 0.0043 0.0164 0.0246
Brugia malayi hypothetical protein 0.0048 0.0202 0.0304
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0084 0.047 0.0709
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0023 0.0019
Brugia malayi steroid hormone receptor 0.0091 0.052 0.0785
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0137 0.087 0.1902
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0194 0.0202
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0018 0.0026
Schistosoma mansoni calcium-transporting atpase sarcoplasmic/endoplasmic reticulum type (calcium pump) 0.0041 0.0149 0.0135
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Mycobacterium ulcerans aldehyde dehydrogenase 0.0193 0.1281 0.2821
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.0468 0.0706
Loa Loa (eye worm) acyl carrier protein 0.0036 0.0116 0.0175
Brugia malayi PHD-finger family protein 0.0029 0.0059 0.0089
Trichomonas vaginalis glutaminase, putative 0.0325 0.2268 0.2418
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Toxoplasma gondii cytochrome p450 superfamily protein 0.0029 0.0064 0.0497
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0041 0.015 0.1167
Mycobacterium ulcerans polyketide synthase Pks9 0.0052 0.0235 0.0484
Schistosoma mansoni alpha glucosidase 0.0036 0.0111 0.0096
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0023 0.002 0.0021
Leishmania major hypothetical protein, conserved 0.0025 0.003 0.0099
Brugia malayi E1-E2 ATPase family protein 0.0027 0.0045 0.0066
Trypanosoma cruzi P-type H+-ATPase, putative 0.0024 0.0026 0.0392
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0049 0.0207 0.0422
Onchocerca volvulus 0.0093 0.0537 0.0687
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0304
Loa Loa (eye worm) hypothetical protein 0.0048 0.0202 0.0304
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0164 0.0146
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.033 0.5123
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0032 0.0084 0.0066
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0079 0.1225
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0044 0.0174 0.018
Brugia malayi hypothetical protein 0.0114 0.0698 0.1055
Loa Loa (eye worm) calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type 0.0025 0.0035 0.0051
Schistosoma mansoni hypothetical protein 0.0029 0.0064 0.005
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0092 0.0093
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0193 0.1281 0.1266
Plasmodium falciparum JmjC domain-containing protein, putative 0.0043 0.017 0.7123
Schistosoma mansoni pyruvate kinase 0.004 0.0143 0.0129
Schistosoma mansoni hypothetical protein 0.0102 0.0607 0.0593
Brugia malayi CHE-14 protein 0.0084 0.047 0.0709
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0091 0.052 0.0785
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Loa Loa (eye worm) hypothetical protein 0.0053 0.0242 0.0365
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0643 0.0681
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.0698 0.0682
Leishmania major cytochrome p450-like protein 0.0049 0.0207 0.1496
Onchocerca volvulus 0.0081 0.0447 0.0567
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0624 0.4496 1
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0029 0.0064 0.0104
Loa Loa (eye worm) hypothetical protein 0.0134 0.0841 0.1271
Brugia malayi Cytochrome P450 family protein 0.0049 0.0207 0.0312
Echinococcus multilocularis nervana 2 0.0241 0.1644 0.1629
Loa Loa (eye worm) hypothetical protein 0.0091 0.052 0.0785
Echinococcus multilocularis pyruvate kinase 0.004 0.0143 0.0126
Schistosoma mansoni hypothetical protein 0.0068 0.0354 0.034
Trypanosoma brucei calcium motive p-type ATPase, putative 0.0041 0.0149 0.2095
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0346 0.0332
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0043 0.0164 0.0192
Entamoeba histolytica hypothetical protein 0.0114 0.0698 0.0746
Echinococcus multilocularis expressed conserved protein 0.0183 0.1212 0.1196
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.0643 0.0629
Brugia malayi glutathione reductase 0.0047 0.0192 0.0289
Echinococcus multilocularis lamin 0.0053 0.0242 0.0225
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 0.0041 0.0149 0.1156
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0031 0.0079 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0029 0.0064 0.0104
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0079 0.0434 0.0927
Mycobacterium ulcerans polyketide synthase 0.0079 0.0434 0.093
Mycobacterium leprae conserved hypothetical protein 0.0051 0.0226 0.0461
Loa Loa (eye worm) cytochrome P450 0.0029 0.0064 0.0096
Plasmodium vivax glutathione reductase, putative 0.0047 0.0192 0.2046
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0624 0.4496 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0064 0.0319 0.067
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0643 0.097
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0643 0.0681
Trypanosoma brucei calcium-translocating P-type ATPase 0.0041 0.0149 0.2095
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0061 0.0046
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0084 0.0471 0.0454
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0043 0.017 0.1319
Onchocerca volvulus 0.0144 0.0921 0.1197
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0029 0.0064 0.0104
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.104 0.1024
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0099 0.0585 0.0571
Echinococcus granulosus L aminoadipate semialdehyde 0.0181 0.1198 0.1182
Brugia malayi glutaminase DH11.1 0.0325 0.2268 0.3428
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0043 0.017 0.2429
Plasmodium vivax pyruvate kinase, putative 0.004 0.0143 0.1429
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0041 0.0149 0.0154
Brugia malayi jmjC domain containing protein 0.0222 0.1502 0.2269
Brugia malayi hypoxia-induced factor 1 0.0148 0.095 0.1434
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0066 0.0336 0.0707
Echinococcus granulosus expressed protein 0.0367 0.2582 0.2569
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.029 0.2003 0.1989
Trypanosoma brucei cytochrome P450, putative 0.0049 0.0207 0.3026
Schistosoma mansoni thyroid hormone receptor 0.0091 0.052 0.0506
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0079 0.0079
Leishmania major vacuolar-type Ca2 -ATPase, putative 0.0042 0.0155 0.1087
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Entamoeba histolytica pyruvate kinase, putative 0.0028 0.0053 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.052 0.0503
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.029 0.2003 0.1989
Schistosoma mansoni na+/k+ atpase alpha subunit 0.0085 0.0479 0.0465
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0051 0.0227 0.177
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.0346 0.0365
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.033 0.5123
Loa Loa (eye worm) hypothetical protein 0.0037 0.0119 0.0179
Schistosoma mansoni cytochrome P450 0.0029 0.0064 0.005
Schistosoma mansoni steroid hormone receptor ad4bp 0.0091 0.052 0.0506
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0091 0.052 0.0506
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0091 0.052 0.0785
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0195 0.13 0.1389
Loa Loa (eye worm) steroid hormone receptor 0.0091 0.052 0.0785
Brugia malayi Nuclear hormone receptor-like 1 0.0048 0.0202 0.0304
Giardia lamblia Pyruvate kinase 0.004 0.0143 0.0134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0267
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0061 0.047
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0043 0.017 0.2631
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0019 0.0003
Mycobacterium ulcerans hypothetical protein 0.0023 0.0019 0.0003
Schistosoma mansoni hypothetical protein 0.0081 0.0447 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0091 0.052 0.0785
Echinococcus granulosus cytochrome P450 2K1 0.0029 0.0064 0.0047
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0061 0.006
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0194 0.0232
Trichomonas vaginalis guanylate cyclase, putative 0.0031 0.0079 0.0079
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0051 0.0226 0.0464
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0267
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.0643 0.1392
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0091 0.052 0.0503
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0118 0.0725 0.158
Brugia malayi 6-phosphofructokinase 0.0107 0.0643 0.097
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0468 0.0494
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0031 0.0079 0.1225
Onchocerca volvulus 0.0053 0.0242 0.0296
Mycobacterium tuberculosis Probable thioesterase TesA 0.0066 0.0336 0.0711
Loa Loa (eye worm) cytochrome P450 family protein 0.0049 0.0207 0.0312
Brugia malayi Intermediate filament tail domain containing protein 0.0053 0.0242 0.0365
Echinococcus granulosus Nuclear hormone receptor HR96 0.0043 0.0164 0.0146
Echinococcus multilocularis musashi 0.0053 0.0242 0.0225
Trichomonas vaginalis chromobox protein, putative 0.0084 0.0468 0.0494
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0091 0.052 0.0785
Onchocerca volvulus 0.0058 0.0276 0.0341
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0267
Echinococcus granulosus FTZ F1 alpha 0.0091 0.052 0.0503
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.0643 0.097
Brugia malayi Cytochrome P450 family protein 0.0109 0.0655 0.0988
Echinococcus granulosus chromobox protein 1 0.0084 0.0468 0.0451
Echinococcus multilocularis phd:f box containing protein 0.0043 0.017 0.0152
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.033 0.0316
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.104 0.1024
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0091 0.052 0.0503
Brugia malayi hypothetical protein 0.0043 0.0164 0.0246
Echinococcus multilocularis chromobox protein 1 0.0084 0.0468 0.0451
Schistosoma mansoni nuclear hormone receptor 0.0043 0.0164 0.015
Toxoplasma gondii type I fatty acid synthase, putative 0.0056 0.0265 0.206
Schistosoma mansoni hypothetical protein 0.0539 0.3863 0.3854
Mycobacterium tuberculosis Hypothetical protein 0.0024 0.0023 0.0011
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0118 0.0725 0.158
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0032 0.0084 0.0147
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0036 0.0111 0.0113
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0725 0.1579
Trypanosoma cruzi cytochrome P450, putative 0.0049 0.0207 0.3212
Trypanosoma cruzi pyruvate kinase 2, putative 0.004 0.0143 0.2223
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0043 0.017 0.0155
Brugia malayi ecdysteroid receptor 0.0091 0.052 0.0785
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0019 0.0012
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.0166
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0018 0.0004
Schistosoma mansoni hypothetical protein 0.0058 0.0276 0.0262
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0636 0.1381
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0019 0.0003
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0084 0.0471 0.1011
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0091 0.052 0.0503
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.016
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0024 0.0027 0.0019
Trypanosoma cruzi Putative Phosphatase/Protein of unknown function DUF89, putative 0.0054 0.0245 0.3801
Mycobacterium tuberculosis Possible metal cation transporting P-type ATPase CtpH 0.0026 0.0041 0.0052
Echinococcus multilocularis neutral alpha glucosidase AB 0.0036 0.0111 0.0093
Echinococcus multilocularis L aminoadipate semialdehyde 0.0181 0.1198 0.1182
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0042 0.0155 0.2406
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0059 0.0042
Brugia malayi Melibiase family protein 0.0067 0.0346 0.0522
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0029 0.0064 0.0992
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.0166
Loa Loa (eye worm) pyruvate kinase 0.004 0.0143 0.0216
Loa Loa (eye worm) hypothetical protein 0.0083 0.0467 0.0705
Onchocerca volvulus 0.0086 0.0485 0.0618
Schistosoma mansoni jun-related protein 0.0068 0.0354 0.034
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.0346 0.0332
Echinococcus granulosus cpg binding protein 0.0036 0.0115 0.0097
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0117 0.0716 0.1081
Plasmodium vivax JmjC domain containing protein 0.0043 0.017 0.176
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0091 0.052 0.0785
Echinococcus multilocularis nuclear receptor nhr 48 0.0043 0.0164 0.0146
Schistosoma mansoni lamin 0.0053 0.0242 0.0228
Brugia malayi PAS domain containing protein 0.0121 0.0745 0.1125
Brugia malayi jmjC domain containing protein 0.0043 0.017 0.0255
Echinococcus granulosus geminin 0.0539 0.3863 0.3852
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0019 0.0003
Onchocerca volvulus Pyruvate kinase homolog 0.004 0.0143 0.0165
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0061 0.047
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0029 0.0064 0.0104
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0029 0.0064 0.0104
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.0643 1
Echinococcus granulosus expressed conserved protein 0.0183 0.1212 0.1196
Loa Loa (eye worm) hypothetical protein 0.0025 0.003 0.0044
Leishmania major hypothetical protein, conserved 0.0054 0.0245 0.1795
Echinococcus multilocularis protein patched 0.0084 0.047 0.0453
Loa Loa (eye worm) CXXC zinc finger family protein 0.0034 0.01 0.015
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.033 0.0312
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0029 0.0064 0.0104
Leishmania major pyruvate kinase 0.004 0.0143 0.0994
Schistosoma mansoni plasma membrane calcium-transporting atpase 0.0041 0.0149 0.0135
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0145 0.0923 0.091
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0019 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0091 0.052 0.0785
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0099 0.0585 0.0568
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0084 0.0471 0.0454
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0079 0.0434 0.0927
Echinococcus granulosus jumonji domain containing protein 0.004 0.0143 0.0125
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0043 0.0164 0.015
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0029 0.0064 0.0104
Schistosoma mansoni lamin 0.0053 0.0242 0.0228
Plasmodium falciparum glutathione reductase 0.0047 0.0192 0.8284
Loa Loa (eye worm) hypothetical protein 0.0043 0.0164 0.0246
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.033 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0061 0.006
Schistosoma mansoni patched 1 0.0084 0.047 0.0456
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0084 0.0471 0.1011
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0137 0.087 0.0853
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1278 0.9364 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0111 0.1712
Echinococcus granulosus lysine specific demethylase 6a 0.0043 0.017 0.0152
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0059 0.0045
Echinococcus granulosus lamin 0.0053 0.0242 0.0225
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0037 0.0019
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0051 0.0226 1
Schistosoma mansoni cpg binding protein 0.0036 0.0115 0.01
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0018 0.0014
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0091 0.052 0.0506
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0125 0.078 0.0764
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0029 0.0064 0.0104
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0042 0.0155 0.016
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0018 0.0267
Loa Loa (eye worm) hypothetical protein 0.0043 0.017 0.0255
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0018 0.0004
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0636 0.1381
Brugia malayi hypothetical protein 0.0043 0.0164 0.0246
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0019 0.0003
Echinococcus multilocularis aryl hydrocarbon receptor 0.017 0.1111 0.1095
Brugia malayi jmjC domain containing protein 0.0043 0.017 0.0255
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0044 0.0174 0.0186
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0029 0.0064 0.0104
Brugia malayi nuclear hormone receptor family member nhr-6 0.0043 0.0164 0.0246
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0029 0.0064 0.0104
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0137 0.087 0.1902
Loa Loa (eye worm) hypothetical protein 0.0029 0.0059 0.0089
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0636 0.1381
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0051 0.0226 1
Echinococcus granulosus plasma membrane calcium transporting ATPase 0.0041 0.0149 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0091 0.052 0.0785
Mycobacterium tuberculosis Conserved protein 0.0024 0.0023 0.0011
Leishmania major hypothetical protein, conserved 0.0043 0.017 0.1201
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0624 0.4496 1
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0029 0.0064 0.0104
Schistosoma mansoni glutaminase 0.0325 0.2268 0.2257
Echinococcus granulosus Protein patched homolog 1 0.0084 0.047 0.0453
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0029 0.0064 0.0104
Onchocerca volvulus 0.009 0.0516 0.0659
Echinococcus multilocularis JmjC domain containing protein 4 0.0043 0.017 0.0152
Brugia malayi Nuclear hormone receptor E75 0.0043 0.0164 0.0246
Loa Loa (eye worm) hypothetical protein 0.004 0.0143 0.0216
Echinococcus granulosus chromobox protein 1 0.0084 0.0468 0.0451
Onchocerca volvulus 0.0091 0.052 0.0665
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.0643 0.0681
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0092 0.0093
Schistosoma mansoni single-minded 0.0121 0.0745 0.0732
Mycobacterium leprae PROBABLE CATION-TRANSPORTER ATPASE I CTPI 0.0071 0.0371 0.0786
Mycobacterium ulcerans putative regulatory protein 0.0089 0.0511 0.1102
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0042 0.0155 0.0147
Schistosoma mansoni nuclear hormone receptor 0.0091 0.052 0.0506
Mycobacterium ulcerans polyketide synthase Pks13 0.0118 0.0725 0.158
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0192 0.0175
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0031 0.0079 0.1225
Loa Loa (eye worm) hypothetical protein 0.0023 0.0018 0.0026
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0126 0.0108
Leishmania major calcium-translocating P-type ATPase 0.0042 0.0155 0.1087
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0222 0.1502 0.1487
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0029 0.0064 0.0104
Brugia malayi F/Y-rich N-terminus family protein 0.0025 0.0029 0.0043
Brugia malayi Bromodomain containing protein 0.0029 0.0059 0.0089
Brugia malayi follicle stimulating hormone receptor 0.0243 0.1654 0.2499
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0051 0.0226 0.0177
Schistosoma mansoni nuclear receptor nhr-48 0.0043 0.0164 0.015
Loa Loa (eye worm) hypothetical protein 0.0052 0.0235 0.0354
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0137 0.087 0.0857
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0059 0.0457
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0091 0.052 0.0506
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0091 0.052 0.0503
Onchocerca volvulus 0.0037 0.0119 0.0132
Leishmania major protein kinase, putative 0.0031 0.0079 0.0487
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0031 0.0079 0.1225
Schistosoma mansoni hypothetical protein 0.0543 0.3893 0.3885
Mycobacterium ulcerans thioesterase 0.0066 0.0336 0.0711
Leishmania major calcium-transporting ATPase, putative 0.0041 0.0149 0.1036
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0051 0.0226 0.247
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0061 0.006
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0019 0.0021
Loa Loa (eye worm) hypothetical protein 0.0131 0.0822 0.1241
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0043 0.0164 0.0146
Brugia malayi Na,K-ATPase alpha subunit 0.0088 0.0504 0.0761
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0051 0.0226 0.1758
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.029 0.2003 0.1989
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0018 0.0267
Echinococcus granulosus nervana 2 0.029 0.2003 0.1989
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0018 0.0019
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0061 0.1561
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0091 0.052 0.0506
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0131 0.0822 0.0808
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0029 0.0064 0.0104
Brugia malayi nuclear hormone receptor family member odr-7 0.0043 0.0164 0.0246
Brugia malayi Pre-SET motif family protein 0.0131 0.0822 0.1241
Onchocerca volvulus 0.0053 0.0242 0.0296
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0059 0.0089
Leishmania major hypothetical protein, conserved 0.0024 0.0023 0.004
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0091 0.052 0.0503
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0042 0.0155 0.2406
Brugia malayi Methyltransferase-like protein 4 0.0024 0.0023 0.0033
Leishmania major calcium motive p-type ATPase, putative 0.0041 0.0149 0.1036
Echinococcus granulosus nervana 2 0.0241 0.1644 0.1629
Brugia malayi AMP-binding enzyme family protein 0.0081 0.0447 0.0674
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0101 0.0597 0.0583
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 0.0038 0.013 0.012
Echinococcus granulosus ecdysone induced protein 78C 0.0091 0.052 0.0503
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0019 0.0012

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 4 uM In vitro inhibitory concentration of the compound against dog kidney Na+/K+ ATPase ChEMBL. 10882359

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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