Detailed information for compound 1680916

Basic information

Technical information
  • TDR Targets ID: 1680916
  • Name: (1R,2R,3S)-2-[(1R)-1-amino-2-hydroxy-2-oxoeth yl]-3-phenylcyclopropane-1-carboxylic acid
  • MW: 235.236 | Formula: C12H13NO4
  • H donors: 3 H acceptors: 4 LogP: -2.05 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)[C@@H]([C@@H]1[C@@H]([C@H]1C(=O)O)c1ccccc1)N
  • InChi: 1S/C12H13NO4/c13-10(12(16)17)8-7(9(8)11(14)15)6-4-2-1-3-5-6/h1-5,7-10H,13H2,(H,14,15)(H,16,17)/t7-,8+,9+,10+/m0/s1
  • InChiKey: IFLWVSHRWAIVQF-SGIHWFKDSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (1R,2R,3S)-2-[(1R)-1-amino-2-hydroxy-2-oxo-ethyl]-3-phenyl-cyclopropane-1-carboxylic acid
  • (1R,2R,3S)-2-[(1R)-1-amino-2-hydroxy-2-oxoethyl]-3-phenyl-1-cyclopropanecarboxylic acid
  • (1R,2R,3S)-2-[(1R)-1-amino-2-hydroxy-2-keto-ethyl]-3-phenyl-cyclopropane-1-carboxylic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Glutamate receptor ionotropic, kainate Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, kainate   956 aa 872 aa 38.0 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, kainate   956 aa 868 aa 37.8 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, kainate   956 aa 780 aa 35.6 %
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 Glutamate receptor ionotropic, kainate   956 aa 823 aa 37.9 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, kainate   956 aa 780 aa 36.0 %
Drosophila melanogaster Glutamate receptor IA Glutamate receptor ionotropic, kainate   956 aa 767 aa 33.4 %
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 Glutamate receptor ionotropic, kainate   956 aa 846 aa 26.4 %
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 Glutamate receptor ionotropic, kainate   956 aa 823 aa 37.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0144 0.0128
Loa Loa (eye worm) DR-78 0.0066 0.0256 0.024
Leishmania major fk506-binding protein 1-like protein 0.0209 0.1077 0.4057
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0459 0.1609
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0252 0.1321 0.1301
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Schistosoma mansoni potassium channel tetramerization domain-containing 0.0039 0.0103 0.0081
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0209 0.1077 0.1042
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0091
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0209 0.1077 0.3987
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0028 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Echinococcus multilocularis somatostatin receptor 0.0253 0.1328 0.1681
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0181 0.0229
Echinococcus multilocularis potassium voltage gated channel subfamily KQT 0.0034 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0459 0.1707
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0452 0.0431
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0167
Schistosoma mansoni septate junction protein 0.0035 0.0079 0.0057
Toxoplasma gondii PAN domain-containing protein 0.0286 0.1515 0.5668
Echinococcus multilocularis transient receptor potential gamma protein 0.0034 0.0072 0.0091
Onchocerca volvulus 0.01 0.0452 0.1574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0051 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-19 0.014 0.0679 0.0642
Brugia malayi celfurPC protein 0.1361 0.7674 0.7665
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0898 0.5022 0.5022
Trypanosoma cruzi hypothetical protein, conserved 0.0482 0.2641 1
Brugia malayi Nuclear hormone receptor E75 0.0066 0.0256 0.0217
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0066 0.0256 0.0324
Echinococcus multilocularis g protein coupled receptor 0.0253 0.1328 0.1681
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0091
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0043 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0944 0.5283 1
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0072
Schistosoma mansoni bromodomain containing protein 0.0072 0.029 0.0268
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0181 0.0912 0.0912
Echinococcus granulosus transient receptor potential gamma protein 0.0034 0.0072 0.0072
Brugia malayi K+ channel tetramerisation domain containing protein 0.0039 0.0103 0.0063
Echinococcus granulosus importin subunit beta 1 0.0028 0.0041 0.0041
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0253 0.1328 0.1328
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0577 0.3186 0.6022
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0253 0.1328 0.1681
Loa Loa (eye worm) G-protein coupled receptor 0.0253 0.1328 0.1314
Schistosoma mansoni biogenic amine receptor 0.0253 0.1328 0.1309
Echinococcus granulosus hypothetical protein 0.0034 0.0072 0.0072
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0034 0.0072 0.0091
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0209 0.1077 0.3987
Toxoplasma gondii subtilisin SUB9 0.0099 0.0442 0.1544
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.0564 0.0549
Echinococcus granulosus glycoprotein Antigen 5 0.0252 0.1321 0.1321
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0671 0.0671
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0072 0.0119
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Echinococcus granulosus cpg binding protein 0.0061 0.023 0.023
Toxoplasma gondii subtilisin SUB7 0.0099 0.0442 0.1544
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0253 0.1328 0.1309
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0066 0.0256 0.0217
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0039 0.0103 0.0086
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0209 0.1077 0.4012
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Toxoplasma gondii subtilisin SUB8 0.0099 0.0442 0.1544
Trypanosoma brucei PAB1-binding protein , putative 0.0101 0.0459 0.4036
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0034 0.0072 0.0072
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0091
Brugia malayi Glutamate receptor 1 precursor 0.004 0.0109 0.007
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0253 0.1328 0.1314
Echinococcus multilocularis potassium voltage gated channel protein 0.0898 0.5022 0.6355
Echinococcus granulosus potassium voltage gated channel protein 0.0898 0.5022 0.5022
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0028 0.004 0.005
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni amine GPCR 0.0253 0.1328 0.1309
Echinococcus granulosus notch 0.0035 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Echinococcus granulosus shaker cognate 0.0073 0.0296 0.0296
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0029 0.0043 0.0125
Brugia malayi hypothetical protein 0.01 0.0452 0.0414
Onchocerca volvulus 0.0071 0.0287 0.0939
Onchocerca volvulus 0.0034 0.0072 0.0111
Brugia malayi Kringle domain containing protein 0.0482 0.2641 0.2612
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.0296 0.0275
Plasmodium falciparum subtilisin-like protease 2 0.0099 0.0442 0.1544
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0442 0.082
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0072 0.005
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0167
Trypanosoma brucei potassium voltage-gated channel, putative 0.0039 0.0103 0.0596
Brugia malayi G-protein coupled receptor 0.0253 0.1328 0.1294
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0086
Schistosoma mansoni ryanodine receptor related 0.0034 0.0072 0.005
Echinococcus granulosus G protein coupled receptor 139 0.0253 0.1328 0.1328
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0034 0.0072 0.0111
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0066 0.0256 0.0256
Onchocerca volvulus 0.0253 0.1328 0.4947
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0167
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.014 0.0679 0.0679
Schistosoma mansoni glutamate receptor kainate 0.004 0.0109 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Echinococcus granulosus hyperpolarization activated cyclic 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0037 0.0037
Echinococcus granulosus muscleblind protein 0.0286 0.1517 0.1517
Loa Loa (eye worm) hypothetical protein 0.0101 0.0459 0.0443
Loa Loa (eye worm) hypothetical protein 0.01 0.0452 0.0436
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0209 0.1077 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.014 0.0679 0.0679
Onchocerca volvulus Putative nachr subunit 0.009 0.0396 0.1358
Schistosoma mansoni hypothetical protein 0.0061 0.0227 0.0206
Loa Loa (eye worm) TYRA-2 protein 0.0253 0.1328 0.1314
Brugia malayi K+ channel tetramerisation domain containing protein 0.0039 0.0103 0.0063
Giardia lamblia Fructose-bisphosphate aldolase 0.029 0.1539 0.5801
Trypanosoma brucei potassium voltage-gated channel, putative 0.0039 0.0103 0.0596
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.0296 0.0275
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.0072 0.0119
Brugia malayi beta-lactamase family protein 0.0071 0.0287 0.0248
Loa Loa (eye worm) hypothetical protein 0.0327 0.1748 0.1735
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.014 0.0679 0.0859
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.0371 0.0371
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Brugia malayi Trypsin-like protease protein 5 0.01 0.0452 0.0414
Trypanosoma cruzi potassium voltage-gated channel 0.0039 0.0103 0.0352
Loa Loa (eye worm) hypothetical protein 0.0074 0.0301 0.0285
Brugia malayi nuclear receptor RXR 0.0066 0.0256 0.0217
Echinococcus multilocularis dro:myosuppressin receptor 0.0253 0.1328 0.1681
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0209 0.1077 0.6983
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-33, BmFKBP-33 0.0029 0.0043 0.0003
Toxoplasma gondii kringle domain-containing protein 0.0482 0.2641 1
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0072
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0034 0.0072 0.0235
Echinococcus multilocularis enteropeptidase 0.0252 0.1321 0.1671
Onchocerca volvulus 0.01 0.0452 0.1574
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0186 0.0943 0.0943
Brugia malayi mbt repeat family protein 0.0046 0.0144 0.0105
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0256 0.0234
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0078 0.0078
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0209 0.1077 0.4057
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0103 0.0081
Echinococcus multilocularis muscleblind protein 0.0286 0.1517 0.192
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0253 0.1328 0.1294
Trypanosoma brucei btb/poz domain containing protein, putative 0.0039 0.0103 0.0596
Plasmodium vivax SET domain protein, putative 0.003 0.0051 0.0038
Echinococcus granulosus Potassium voltage gated channel protein Shaw 0.0073 0.0296 0.0296
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0287 0.2359
Brugia malayi follicle stimulating hormone receptor 0.0253 0.1328 0.1294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Brugia malayi ecdysone receptor 0.0066 0.0256 0.0217
Schistosoma mansoni transient receptor potential channel 4 0.0034 0.0072 0.005
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0209 0.1077 0.1077
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0099 0.0442 0.1643
Schistosoma mansoni hypothetical protein 0.01 0.0452 0.0431
Loa Loa (eye worm) hypothetical protein 0.0047 0.0145 0.0129
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.009 0.0396 0.0358
Mycobacterium tuberculosis Probable proline rich membrane-anchored mycosin MycP5 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-5) 0.0099 0.0442 0.163
Schistosoma mansoni hypothetical protein 0.0028 0.004 0.0017
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0034 0.0072 0.005
Brugia malayi Subtilase family protein 0.0375 0.2026 0.1995
Echinococcus multilocularis neurogenic locus protein delta 0.0035 0.0079 0.01
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0091
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0046 0.0139 0.0139
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.0371 0.1271
Echinococcus multilocularis neuropeptide s receptor 0.0253 0.1328 0.1681
Loa Loa (eye worm) Kv4.2 voltage-gated potassium channel 0.0039 0.0103 0.0086
Schistosoma mansoni hypothetical protein 0.0029 0.0043 0.0021
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Schistosoma mansoni steroid hormone receptor ad4bp 0.014 0.0679 0.0658
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0171 0.086 0.084
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.014 0.0679 0.0859
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0253 0.1328 0.1294
Plasmodium vivax kelch protein K13, putative 0.0039 0.0103 0.0237
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.01 0.0452 0.0572
Schistosoma mansoni cpg binding protein 0.0061 0.023 0.0208
Echinococcus granulosus thyroid hormone receptor alpha 0.0066 0.0256 0.0256
Echinococcus granulosus neurogenic locus protein delta 0.0035 0.0079 0.0079
Echinococcus multilocularis epidermal growth factor receptor 0.0313 0.1673 0.2117
Brugia malayi Nuclear hormone receptor E75 0.0066 0.0256 0.0217
Brugia malayi neuroendocrine convertase 1 precursor 0.1685 0.9531 0.9529
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.0296 0.0275
Schistosoma mansoni adenoreceptor 0.0253 0.1328 0.1309
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0253 0.1328 0.4947
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0209 0.1077 0.1058
Echinococcus granulosus potassium channel KvQLT family member kqt 1 0.0034 0.0072 0.0072
Toxoplasma gondii subtilisin SUB12 0.0117 0.0548 0.1949
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0034 0.0072 0.0032
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0256 0.0234
Echinococcus granulosus protein jagged 1 0.0035 0.0079 0.0079
Leishmania major peptidylprolyl isomerase-like protein 0.0209 0.1077 0.4057
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0253 0.1328 0.1309
Loa Loa (eye worm) voltage-gated potassium channel 0.0034 0.0072 0.0055
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis conserved hypothetical protein 0.0034 0.0072 0.0091
Brugia malayi K+ channel tetramerisation domain containing protein 0.0039 0.0103 0.0063
Echinococcus multilocularis neuropeptide Y receptor 0.0253 0.1328 0.1681
Echinococcus granulosus membrane bound transcription factor site 1 0.0099 0.0442 0.0442
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0153 0.0153
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0066 0.0256 0.0324
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0051 0.0029
Echinococcus multilocularis fibrillin 1 0.0055 0.0192 0.0242
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0074 0.0301 0.028
Onchocerca volvulus 0.0187 0.0952 0.3497
Brugia malayi nuclear receptor NHR-67 0.0066 0.0256 0.0217
Schistosoma mansoni transient receptor potential channel 0.0034 0.0072 0.005
Brugia malayi Transient-receptor-potential like protein 0.0034 0.0072 0.0032
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0109 0.0087
Loa Loa (eye worm) proprotein convertase 2 0.0577 0.3186 0.3175
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0144 0.0122
Echinococcus multilocularis cpg binding protein 0.0061 0.023 0.0291
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.014 0.0679 0.0664
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni thyroid hormone receptor 0.014 0.0679 0.0658
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0287 0.0997
Loa Loa (eye worm) subtilase 0.0375 0.2026 0.2013
Plasmodium vivax ataxin-2 like protein, putative 0.0101 0.0459 0.1609
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.0371 0.1271
Echinococcus multilocularis neuropeptide FF receptor 2 0.0253 0.1328 0.1681
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Echinococcus multilocularis neurogenic locus notch protein 0.0035 0.0079 0.01
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0029 0.0043 0.0008
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.0439 0.1629
Loa Loa (eye worm) hypothetical protein 0.0028 0.004 0.0023
Loa Loa (eye worm) hypothetical protein 0.1767 1 1
Toxoplasma gondii hypothetical protein 0.0034 0.0072 0.0119
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0066 0.0256 0.0234
Onchocerca volvulus 0.0066 0.0256 0.0819
Schistosoma mansoni lipoxygenase 0.0117 0.0546 0.0525
Loa Loa (eye worm) TK/ROR protein kinase 0.0482 0.2641 0.2629
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0028 0.004 0.005
Brugia malayi hypothetical protein 0.0101 0.0459 0.0421
Echinococcus granulosus alpha 1A adrenergic receptor 0.0253 0.1328 0.1328
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0125
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit 0.0034 0.0072 0.0032
Echinococcus granulosus Nuclear hormone receptor HR96 0.0066 0.0256 0.0256
Brugia malayi putative neuropeptide receptor 0.0253 0.1328 0.1294
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0034 0.0072 0.0091
Echinococcus multilocularis dnaJ subfamily B 0.0405 0.2196 0.2779
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0034 0.0072 0.0072
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.004 0.0109 0.0138
Echinococcus multilocularis potassium voltage gated channel subfamily C 0.0073 0.0296 0.0375
Echinococcus granulosus dro:myosuppressin receptor 0.0253 0.1328 0.1328
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.014 0.0679 0.0664
Loa Loa (eye worm) voltage-gated potassium channel 0.0073 0.0296 0.028
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0034 0.0072 0.0072
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Trypanosoma cruzi potassium voltage-gated channel, putative 0.0039 0.0103 0.0352
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0898 0.5022 0.5002
Schistosoma mansoni myosin xvIII 0.0253 0.1328 0.1309
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0357 0.1924 0.1911
Schistosoma mansoni glutamate receptor AMPA 0.004 0.0109 0.0087
Brugia malayi Voltage-gated potassium channel, Shab-family (KCNB, Kv2-like) alpha-subunit. C. elegans exp-2 ortholog 0.0073 0.0296 0.0258
Echinococcus granulosus two pore calcium channel protein 1 0.0034 0.0072 0.0072
Giardia lamblia Histone acetyltransferase GCN5 0.0077 0.0318 0.1067
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.0689 0.2639
Brugia malayi sulfakinin receptor protein 0.0253 0.1328 0.1294
Loa Loa (eye worm) glutamate receptor 2 0.004 0.0109 0.0093
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0073 0.0296 0.0258
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0153 0.0153
Schistosoma mansoni hypothetical protein 0.0181 0.0916 0.0896
Schistosoma mansoni voltage-gated potassium channel KCNQ 0.0034 0.0072 0.005
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Loa Loa (eye worm) neuropeptide F receptor 0.0253 0.1328 0.1314
Echinococcus granulosus g protein coupled receptor 0.0253 0.1328 0.1328
Echinococcus granulosus tm gpcr rhodopsin 0.0253 0.1328 0.1328
Brugia malayi hypothetical protein 0.0056 0.02 0.0161
Brugia malayi G-protein coupled receptor 0.0253 0.1328 0.1294
Schistosoma mansoni nuclear hormone receptor 0.0066 0.0256 0.0234
Brugia malayi Importin beta-1 subunit 0.0028 0.0041 0.0001
Schistosoma mansoni site-1 peptidase (S08 family) 0.0099 0.0442 0.0421
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.027 0.027
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Brugia malayi Serotonin receptor 0.0768 0.4275 0.4252
Mycobacterium ulcerans hypothetical protein 0.01 0.0452 0.3952
Echinococcus granulosus glutamate receptor 2 0.0033 0.0067 0.0067
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.0072 0.0119
Brugia malayi Voltage-gated potassium channel, Shal-family (KCND, Kv4-like) alpha-subunit. C. elegans shl-1 ortholog 0.0039 0.0103 0.0063
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0253 0.1328 0.1309
Schistosoma mansoni two-pore calcium channel 0.0034 0.0072 0.005
Loa Loa (eye worm) FKBP5 protein 0.0209 0.1077 0.1063
Echinococcus granulosus peptide allatostatin:somatostatin 0.0253 0.1328 0.1328
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0227 0.0287
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0155 0.0276
Plasmodium falciparum subtilisin-like protease 3 0.0099 0.0442 0.1544
Onchocerca volvulus Slit protein homolog 0.0035 0.0079 0.0138
Echinococcus granulosus slit 2 protein 0.0035 0.0079 0.0079
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0209 0.1077 0.1042
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0171 0.086 0.1612
Echinococcus granulosus voltage gated potassium channel 0.0073 0.0296 0.0296
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0253 0.1328 0.1328
Schistosoma mansoni hypothetical protein 0.0028 0.004 0.0017
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Schistosoma mansoni neuropeptide receptor 0.0253 0.1328 0.1309
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0053 0.0183 0.0167
Plasmodium falciparum cysteine repeat modular protein 1 0.0482 0.2641 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus peptidase s8 s53 subtilisin kexin sedolisin 0.0197 0.1004 0.1004
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.01 0.0452 0.0572
Schistosoma mansoni immunophilin 0.0181 0.0912 0.0892
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0034 0.0072 0.005
Loa Loa (eye worm) hypothetical protein 0.009 0.0396 0.038
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni importin beta-1 0.0028 0.0041 0.0019
Schistosoma mansoni biogenic amine receptor 0.0253 0.1328 0.1309
Onchocerca volvulus 0.0046 0.0144 0.039
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0287 0.0525
Echinococcus granulosus BTB:POZ domain containing protein KCTD16 0.0039 0.0103 0.0103
Schistosoma mansoni hypothetical protein 0.01 0.0452 0.0431
Schistosoma mansoni alpha-1 adrenergic receptor 0.0253 0.1328 0.1309
Echinococcus granulosus potassium large conductance calcium activated 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Loa Loa (eye worm) TK/EGFR protein kinase 0.0313 0.1673 0.1659
Loa Loa (eye worm) hypothetical protein 0.0071 0.0287 0.0271
Loa Loa (eye worm) hypothetical protein 0.0047 0.0146 0.013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.014 0.0679 0.0658
Brugia malayi Trypsin family protein 0.01 0.0452 0.0414
Brugia malayi hypothetical protein 0.0074 0.0301 0.0263
Brugia malayi nuclear hormone receptor 0.0066 0.0256 0.0217
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0253 0.1328 0.1309
Leishmania major peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0125
Loa Loa (eye worm) hypothetical protein 0.0187 0.0952 0.0937
Onchocerca volvulus Putative cubilin 0.0035 0.0079 0.0138
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0287 0.0248
Trichomonas vaginalis fk506-binding protein, putative 0.0209 0.1077 0.2024
Trypanosoma brucei RNA helicase, putative 0.0143 0.0698 0.6344
Echinococcus multilocularis FTZ F1 alpha 0.014 0.0679 0.0859
Schistosoma mansoni tripeptidyl-peptidase II (S08 family) 0.0375 0.2026 0.2009
Loa Loa (eye worm) hypothetical protein 0.0089 0.0389 0.0373
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Echinococcus granulosus Nuclear hormone receptor HR96 0.0066 0.0256 0.0256
Echinococcus granulosus neuropeptide Y receptor 0.0253 0.1328 0.1328
Brugia malayi G protein-coupled receptor 0.0253 0.1328 0.1294
Onchocerca volvulus 0.0039 0.0103 0.0229
Brugia malayi CXXC zinc finger family protein 0.0056 0.0201 0.0162
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0073 0.0296 0.0375
Echinococcus multilocularis glutamate receptor 2 0.004 0.0109 0.0138
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0253 0.1328 0.1314
Schistosoma mansoni biogenic amine (5HT) receptor 0.0253 0.1328 0.1309
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0029 0.0043 0.5
Schistosoma mansoni fk506 binding protein 0.0029 0.0043 0.0021
Wolbachia endosymbiont of Brugia malayi FKBP-type peptidylprolyl isomerase 0.0029 0.0043 0.5
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0034 0.0072 0.0055
Schistosoma mansoni biogenic amine (5HT) receptor 0.0253 0.1328 0.1309
Schistosoma mansoni nuclear receptor 0.0066 0.0256 0.0234
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0253 0.1328 0.1681
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0144 0.0182
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0479 0.2621 0.4952
Echinococcus granulosus tissue type plasminogen activator 0.0482 0.2641 0.2641
Echinococcus granulosus furin 0.1767 1 1
Onchocerca volvulus 0.0099 0.0442 0.1537
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Schistosoma mansoni thyroid hormone receptor 0.014 0.0679 0.0658
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.0296 0.0275
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0039 0.0103 0.0352
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Schistosoma mansoni transcription factor LCR-F1 0.0056 0.02 0.0178
Echinococcus multilocularis fmrfamide receptor 0.0253 0.1328 0.1681
Schistosoma mansoni ATP-binding cassette transporter 0.004 0.0109 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.014 0.0679 0.0679
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0153 0.0194
Brugia malayi Bromodomain containing protein 0.0044 0.0132 0.0092
Echinococcus multilocularis hyperpolarization activated cyclic 0.0034 0.0072 0.0091
Brugia malayi Calcium binding EGF domain containing protein 0.0035 0.0079 0.0039
Echinococcus multilocularis orexin receptor type 2 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0181 0.0912 0.0897
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0253 0.1328 0.1294
Loa Loa (eye worm) hypothetical protein 0.0896 0.5012 0.5004
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Loa Loa (eye worm) hypothetical protein 0.01 0.0452 0.0436
Echinococcus multilocularis neurogenic locus notch protein 4 0.0035 0.0079 0.01
Onchocerca volvulus 0.0071 0.0287 0.0939
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Echinococcus multilocularis snurportin 1 0.0304 0.1618 0.2047
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Onchocerca volvulus 0.01 0.0452 0.1574
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0181 0.0912 0.1155
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0022 0.0022
Echinococcus multilocularis protein jagged 2 0.0035 0.0079 0.01
Schistosoma mansoni calcium-activated potassium channel 0.0034 0.0072 0.005
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0072 0.0091
Toxoplasma gondii subtilisin SUB6 0.0099 0.0442 0.1544
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Mycobacterium leprae Possible secreted protease 0.0099 0.0442 0.6179
Brugia malayi beta-lactamase 0.0071 0.0287 0.0248
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0056 0.02 0.02
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0034 0.0072 0.0091
Echinococcus granulosus neuroendocrine convertase 2 0.1401 0.7902 0.7902
Brugia malayi hypothetical protein 0.0074 0.0301 0.0263
Onchocerca volvulus 0.0039 0.0103 0.0229
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Plasmodium vivax K+ channel tetramerisation domain containing protein 0.0039 0.0103 0.0237
Mycobacterium tuberculosis Conserved protein 0.0071 0.0287 0.0997
Toxoplasma gondii PAN domain-containing protein 0.0286 0.1515 0.5668
Loa Loa (eye worm) hypothetical protein 0.0482 0.2641 0.2629
Echinococcus multilocularis nuclear receptor nhr 48 0.0066 0.0256 0.0324
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0287 0.0265
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0144 0.0144
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Brugia malayi nuclear hormone receptor family member nhr-6 0.0066 0.0256 0.0217
Schistosoma mansoni hypothetical protein 0.0327 0.1748 0.173
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Onchocerca volvulus 0.0253 0.1328 0.4947
Echinococcus granulosus sodium channel protein 0.0034 0.0072 0.0072
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0287 0.0525
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0034 0.0072 0.0091
Leishmania major hypothetical protein, conserved 0.0039 0.0103 0.0352
Schistosoma mansoni jumonji/arid domain-containing protein 0.0066 0.0256 0.0234
Brugia malayi Calcium binding EGF domain containing protein 0.0035 0.0079 0.0039
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.009 0.0396 0.0396
Schistosoma mansoni amine GPCR 0.0253 0.1328 0.1309
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Schistosoma mansoni voltage-gated potassium channel 0.0039 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0439 0.1629
Brugia malayi Trypsin family protein 0.01 0.0452 0.0414
Mycobacterium tuberculosis Conserved protein 0.0071 0.0287 0.0997
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0066 0.0256 0.0234
Schistosoma mansoni edp1-related 0.0039 0.0103 0.0081
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Giardia lamblia Furin precursor putative serine protease 0.0479 0.2621 1
Schistosoma mansoni hypothetical protein 0.0285 0.1513 0.1494
Schistosoma mansoni voltage-gated cation channel 0.0034 0.0072 0.005
Schistosoma mansoni lipoxygenase 0.0082 0.0345 0.0324
Brugia malayi jmjC domain containing protein 0.0061 0.0227 0.0188
Brugia malayi tailless protein 0.0066 0.0256 0.0217
Onchocerca volvulus 0.01 0.0452 0.1574
Schistosoma mansoni neuropeptide receptor 0.0253 0.1328 0.1309
Echinococcus granulosus g protein coupled receptor 0.0253 0.1328 0.1328
Echinococcus granulosus delta-like protein 1 0.0035 0.0079 0.0079
Echinococcus granulosus biogenic amine 5HT receptor 0.0253 0.1328 0.1328
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0034 0.0072 0.0055
Brugia malayi GCC2 and GCC3 family protein 0.0035 0.0079 0.0039
Loa Loa (eye worm) hypothetical protein 0.0069 0.0273 0.0257
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.014 0.0679 0.0658
Brugia malayi orphan nuclear receptor NR2E1 0.0066 0.0256 0.0217
Brugia malayi Serotonin receptor 0.0253 0.1328 0.1294
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0089 0.0389 0.0373
Leishmania major hypothetical protein, conserved 0.0039 0.0103 0.0352
Trichomonas vaginalis fk506-binding protein, putative 0.0029 0.0043 0.0062
Loa Loa (eye worm) hypothetical protein 0.01 0.0452 0.0436
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0051 0.0038
Brugia malayi Tachykinin-like peptides receptor 99D 0.0253 0.1328 0.1294
Echinococcus multilocularis two pore calcium channel protein 1 0.0034 0.0072 0.0091
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0022 0.0028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Echinococcus granulosus 7tm_1 domain containing protein 0.0253 0.1328 0.1328
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP3 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-3) 0.0099 0.0442 0.163
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0072 0.005
Echinococcus multilocularis short transient receptor potential channel 6 0.0034 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Mycobacterium tuberculosis Conserved protein 0.0071 0.0287 0.0997
Loa Loa (eye worm) hypothetical protein 0.0052 0.0174 0.0158
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.0549 0.1956
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0034 0.0072 0.0032
Toxoplasma gondii subtilisin SUB2 0.0099 0.0442 0.1544
Brugia malayi nuclear hormone receptor family member odr-7 0.0066 0.0256 0.0217
Mycobacterium ulcerans hypothetical protein 0.0071 0.0287 0.2359
Mycobacterium leprae PROBABLE PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP5 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-5) 0.0099 0.0442 0.6179
Brugia malayi Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog 0.0034 0.0072 0.0032
Loa Loa (eye worm) glutamate receptor 1 0.004 0.0109 0.0093
Brugia malayi Nuclear hormone receptor-like 1 0.0074 0.0301 0.0263
Echinococcus granulosus hypothetical protein 0.0253 0.1328 0.1328
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0034 0.0072 0.0072
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0209 0.1077 0.6983
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0287 0.0525
Onchocerca volvulus 0.014 0.0679 0.2448
Schistosoma mansoni neuropeptide f receptor 76f 0.0253 0.1328 0.1309
Loa Loa (eye worm) hypothetical protein 0.0061 0.0227 0.0211
Echinococcus granulosus two pore calcium channel protein 2 0.0034 0.0072 0.0072
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0039 0.0103 0.0237
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis BTB:POZ domain containing protein 0.0039 0.0103 0.013
Schistosoma mansoni zinc finger protein 0.0066 0.0256 0.0234
Plasmodium vivax subtilisin-like serine protease, putative 0.0099 0.0442 0.1544
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.0371 0.0685
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.014 0.0679 0.0664
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0066 0.0256 0.0324
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0227 0.0287
Echinococcus multilocularis neuropeptides capa receptor 0.0253 0.1328 0.1681
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Brugia malayi Cyclic-nucleotide gated cation channel 0.0034 0.0072 0.0032
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.0439 0.0423
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0053 0.0183 0.0144
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0287 0.0363
Trypanosoma brucei FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0029 0.0043 0.002
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.0689 0.6246
Brugia malayi Nuclear hormone receptor-like 1 0.0074 0.0301 0.0263
Schistosoma mansoni biogenic amine receptor 0.0253 0.1328 0.1309
Echinococcus granulosus laminin 0.0053 0.0183 0.0183
Schistosoma mansoni hypothetical protein 0.0181 0.0916 0.0896
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0034 0.0072 0.0032
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0066 0.0256 0.0819
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.014 0.0679 0.0859
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Brugia malayi beta-lactamase family protein 0.0071 0.0287 0.0248
Schistosoma mansoni hypothetical protein 0.0405 0.2196 0.2179
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0227 0.0205
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Loa Loa (eye worm) hypothetical protein 0.0898 0.5022 0.5014
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0155 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0253 0.1328 0.1328
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0442 0.082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.014 0.0679 0.0642
Brugia malayi cation channel family protein 0.0034 0.0072 0.0032
Brugia malayi Calcium binding EGF domain containing protein 0.0035 0.0079 0.0039
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0209 0.1077 0.1364
Echinococcus multilocularis GPCR, family 2 0.0028 0.004 0.005
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Loa Loa (eye worm) hypothetical protein 0.0074 0.0301 0.0285
Echinococcus granulosus transmembrane protease serine 3 0.01 0.0452 0.0452
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus potassium voltage gated channel protein 0.0073 0.0296 0.0296
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0072 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.0564 0.0549
Toxoplasma gondii peptidyl-prolyl isomerase FKBP12, putative 0.0029 0.0043 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0253 0.1328 0.1309
Trypanosoma cruzi FKBP-type peptidylprolyl cis-trans isomerase, putative 0.0029 0.0043 0.0125
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0072
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0287 0.2375
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0671 0.0651
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0287 0.0271
Echinococcus granulosus sodium leak channel non selective protein 0.0034 0.0072 0.0072
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0072 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0577 0.3186 0.6022
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.014 0.0679 0.0679
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.0296 0.0275
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Echinococcus multilocularis thyroid hormone receptor alpha 0.014 0.0679 0.0859
Schistosoma mansoni transient receptor potential channel 0.0034 0.0072 0.005
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0253 0.1328 0.1294
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0287 0.0947
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0034 0.0072 0.0235
Onchocerca volvulus 0.0253 0.1328 0.4947
Echinococcus multilocularis neuropeptide receptor 0.0253 0.1328 0.1681
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Brugia malayi steroid hormone receptor 0.014 0.0679 0.0642
Schistosoma mansoni retinoic acid receptor RXR 0.014 0.0679 0.0658
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0048 0.0153 0.0153
Echinococcus granulosus neuropeptide receptor 0.0253 0.1328 0.1328
Plasmodium vivax subtilisin-like protease 2, putative 0.0099 0.0442 0.1544
Echinococcus multilocularis voltage gated potassium channel 0.0034 0.0072 0.0091
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis sodium channel protein 0.0034 0.0072 0.0091
Brugia malayi neuropeptide F receptor 0.0253 0.1328 0.1294
Echinococcus multilocularis g protein coupled receptor 0.0253 0.1328 0.1681
Schistosoma mansoni notch 0.0035 0.0079 0.0057
Brugia malayi K+ channel tetramerisation domain containing protein 0.0039 0.0103 0.0063
Trypanosoma brucei macrophage infectivity potentiator, precursor, putative 0.0029 0.0043 0.002
Echinococcus granulosus inhibitor of apoptosis protein 0.0327 0.1748 0.1748
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0034 0.0072 0.005
Loa Loa (eye worm) latrophilin receptor protein 2 0.0028 0.004 0.0023
Brugia malayi Membrane-bound transcription factor site-1 protease precursor 0.0099 0.0442 0.0404
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0671 0.085
Plasmodium falciparum histone acetyltransferase GCN5 0.0077 0.0318 0.1066
Loa Loa (eye worm) Notch2 0.0035 0.0079 0.0062
Echinococcus multilocularis allatostatin A receptor 0.0253 0.1328 0.1681
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Schistosoma mansoni immunophilin 0.0209 0.1077 0.1058
Schistosoma mansoni hypothetical protein 0.0406 0.2204 0.2187
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0072 0.0117
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0327 0.1748 0.173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0287 0.0525
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Leishmania major hypothetical protein, conserved 0.0039 0.0103 0.0352
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.0371 0.1271
Brugia malayi proprotein convertase 2 0.1401 0.7902 0.7894
Echinococcus granulosus g protein coupled receptor 0.0253 0.1328 0.1328
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0253 0.1328 0.1309
Loa Loa (eye worm) calcium channel 0.0034 0.0072 0.0055
Brugia malayi AKH receptor 0.0253 0.1328 0.1294
Toxoplasma gondii subtilisin SUB1 0.0099 0.0442 0.1544
Echinococcus multilocularis neuropeptide receptor 0.0253 0.1328 0.1681
Echinococcus multilocularis G protein coupled receptor 139 0.0253 0.1328 0.1681
Toxoplasma gondii K+ channel tetramerisation domain-containing protein 0.0039 0.0103 0.0237
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0041 0.0052
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.01 0.0452 0.0414
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.014 0.0679 0.0658
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0146 0.0185
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0073 0.0296 0.0296
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Trichomonas vaginalis conserved hypothetical protein 0.0073 0.0295 0.0541
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus multilocularis glycoprotein Antigen 5 0.0252 0.1321 0.1671
Schistosoma mansoni nuclear hormone receptor 0.014 0.0679 0.0658
Schistosoma mansoni cpg binding protein 0.0056 0.0201 0.0179
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0051 0.0064
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0181 0.0229
Echinococcus granulosus neurogenic locus notch protein 0.0035 0.0079 0.0079
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.0439 0.0417
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0944 0.5283 0.5283
Toxoplasma gondii kelch repeat and K+ channel tetramerisation domain containing protein 0.0039 0.0103 0.0237
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Loa Loa (eye worm) ryanodine receptor 0.0034 0.0072 0.0055
Onchocerca volvulus 0.0253 0.1328 0.4947
Leishmania major hypothetical protein, conserved 0.0034 0.0072 0.0235
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Onchocerca volvulus 0.0231 0.12 0.4453
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0103 0.0352
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.027 0.0341
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0584 0.3223 0.4079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0072 0.005
Echinococcus granulosus retinoic acid receptor rxr beta a 0.014 0.0679 0.0679
Schistosoma mansoni amine GPCR 0.0253 0.1328 0.1309
Trichomonas vaginalis immunophilin, putative 0.0209 0.1077 0.2024
Onchocerca volvulus Protein ultraspiracle homolog 0.014 0.0679 0.2448
Echinococcus granulosus histone acetyltransferase KAT2B 0.0277 0.1465 0.1465
Echinococcus multilocularis Peptidase S8 S53, subtilisin kexin sedolisin 0.0197 0.1004 0.127
Trypanosoma brucei BTB/POZ domain/Regulator of chromosome condensation (RCC1) repeat, putative 0.0039 0.0103 0.0596
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.0439 0.0439
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0039 0.0103 0.0086
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.014 0.0679 0.0642
Echinococcus granulosus lysine specific demethylase 5A 0.0066 0.0256 0.0256
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0152 0.0135
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus multilocularis g protein coupled receptor 0.0253 0.1328 0.1681
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.0546 0.0546
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni calcium channel voltage-dependent p/q type alpha 1a-related 0.0034 0.0072 0.005
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0048 0.0153 0.0153
Echinococcus multilocularis calcium activated potassium channel 0.0034 0.0074 0.0093
Loa Loa (eye worm) voltage-dependent calcium channel 0.0034 0.0072 0.0055
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Brugia malayi neuropeptide F receptor 0.0253 0.1328 0.1294
Trichomonas vaginalis fk506-binding protein, putative 0.0029 0.0043 0.0062
Echinococcus granulosus hyperpolarization activated cyclic 0.0034 0.0072 0.0072
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.3846 0.4867
Echinococcus multilocularis protein jagged 1 0.0035 0.0079 0.01
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0181 0.0142
Echinococcus granulosus microtubule associated protein 2 0.0693 0.3846 0.3846
Brugia malayi latrophilin 2 splice variant baaae 0.0061 0.0227 0.0188
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0034 0.0072 0.0055
Echinococcus granulosus somatostatin receptor 0.0253 0.1328 0.1328
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.0689 1
Schistosoma mansoni laminin gamma-3 chain 0.0035 0.0079 0.0057
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.0439 0.1629
Entamoeba histolytica hypothetical protein 0.0056 0.02 0.1241
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0327 0.1748 0.2213
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0034 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Toxoplasma gondii subtilisin SUB10 0.0099 0.0442 0.1544
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Toxoplasma gondii transporter, cation channel family protein 0.0034 0.0072 0.0119
Brugia malayi G protein-coupled receptor F59B2.13 0.0253 0.1328 0.1294
Schistosoma mansoni furin-1 (S08 family) 0.0922 0.5159 0.5148
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Echinococcus granulosus fibropellin Ia 0.0035 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Schistosoma mansoni glutamate receptor kainate 0.004 0.0109 0.0087
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0121 0.0569 0.0548
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0304 0.1618 0.1604
Brugia malayi mbt repeat family protein 0.0046 0.0144 0.0105
Loa Loa (eye worm) nuclear receptor NHR-67 0.0066 0.0256 0.024
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0181 0.0159
Echinococcus granulosus neuropeptide receptor A26 0.0253 0.1328 0.1328
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0944 0.5283 0.6686
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.009 0.0396 0.0501
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0209 0.1077 0.6917
Brugia malayi Dopamine receptor 0.0253 0.1328 0.1294
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.0439 0.1523
Echinococcus multilocularis glutamate receptor 2 0.0033 0.0067 0.0085
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Brugia malayi mKIAA0176 protein 0.0039 0.0103 0.0063
Echinococcus granulosus serotonin receptor 0.0253 0.1328 0.1328
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-33 0.0029 0.0043 0.0026
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0253 0.1328 0.1681
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0253 0.1328 0.1314
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0253 0.1328 0.1314
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0406 0.2204 0.416
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0029 0.0043 0.0215
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0287 0.0997
Brugia malayi Cadherin domain containing protein 0.0035 0.0079 0.0039
Schistosoma mansoni amine GPCR 0.0253 0.1328 0.1309
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0066 0.0256 0.0819
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0187 0.0952 0.0932
Brugia malayi Nuclear hormone receptor family member nhr-31 0.014 0.0679 0.0642
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0209 0.1077 0.4057
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0072 0.005
Loa Loa (eye worm) hypothetical protein 0.0073 0.0296 0.028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0146 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Schistosoma mansoni neuropeptide F-like receptor 0.0253 0.1328 0.1309
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0253 0.1328 0.1314
Echinococcus granulosus nuclear receptor 2DBD gamma 0.014 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Onchocerca volvulus 0.0087 0.0378 0.1288
Loa Loa (eye worm) hypothetical protein 0.0029 0.0043 0.0026
Onchocerca volvulus 0.0253 0.1328 0.4947
Brugia malayi Nuclear hormone receptor family member nhr-14 0.014 0.0679 0.0642
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0452 0.0431
Echinococcus granulosus neuropeptides capa receptor 0.0253 0.1328 0.1328
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0066 0.0256 0.0324
Toxoplasma gondii ABC1 family protein 0.0071 0.0287 0.0947
Brugia malayi Voltage-gated calcium channel, P/Q-type, alpha subunit. C. elegans unc-2 ortholog 0.0034 0.0072 0.0032
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0153 0.0194
Onchocerca volvulus 0.0056 0.0201 0.0608
Echinococcus granulosus FTZ F1 alpha 0.014 0.0679 0.0679
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.002
Onchocerca volvulus 0.0253 0.1328 0.4947
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0209 0.1077 0.2024
Onchocerca volvulus Deterin homolog 0.0327 0.1748 0.6564
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0072 0.005
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus voltage dependent calcium channel 0.0034 0.0072 0.0072
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0671 0.0651
Brugia malayi hypothetical protein 0.0066 0.0253 0.0214
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0327 0.1748 0.1716
Treponema pallidum fructose-bisphosphate aldolase 0.029 0.1539 1
Echinococcus granulosus nuclear receptor nhr 48 0.0066 0.0256 0.0256
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-13, BmFKBP-13 0.0029 0.0043 0.0003
Echinococcus multilocularis neurogenic locus protein delta 0.0035 0.0079 0.01
Trypanosoma cruzi macrophage infectivity potentiator, precursor, putative 0.0029 0.0043 0.0125
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus granulosus Tolloid protein 1 0.0053 0.0183 0.0183
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1539 1
Brugia malayi PHD-finger family protein 0.0034 0.0075 0.0036
Brugia malayi Cadherin domain containing protein 0.0035 0.0079 0.0039
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Onchocerca volvulus 0.0035 0.0079 0.0138
Echinococcus multilocularis BTB:POZ domain containing protein KCTD16 0.0039 0.0103 0.013
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Schistosoma mansoni 60S ribosomal protein L21 0.0034 0.0072 0.005
Echinococcus multilocularis potassium large conductance calcium activated 0.0034 0.0072 0.0091
Schistosoma mansoni glutamate receptor NMDA 0.0048 0.0153 0.0131
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Trypanosoma brucei btb/poz domain containing protein, putative 0.0039 0.0103 0.0596
Loa Loa (eye worm) hypothetical protein 0.0074 0.0301 0.0285
Loa Loa (eye worm) hypothetical protein 0.0286 0.1517 0.1503
Brugia malayi Trypsin family protein 0.01 0.0452 0.0414
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Echinococcus granulosus Mastin 0.0252 0.1321 0.1321
Schistosoma mansoni site-1 peptidase (S08 family) 0.0099 0.0442 0.0421
Schistosoma mansoni voltage-dependent calcium channel 0.0034 0.0072 0.005
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0035 0.0079 0.0039
Brugia malayi Steroid receptor seven-up type 2 0.014 0.0679 0.0642
Loa Loa (eye worm) potassium channel tetramerisation domain containing 5 0.0039 0.0103 0.0086
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0034 0.0072 0.005
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0479 0.2621 0.4952
Loa Loa (eye worm) G-protein coupled receptor 0.0253 0.1328 0.1314
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0287 0.1524 0.1505
Schistosoma mansoni hypothetical protein 0.0253 0.1328 0.1309
Trypanosoma brucei subtilisin peptidase 0.0099 0.0442 0.3872
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.014 0.0679 0.0859
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0287 0.0997
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0078 0.0099
Brugia malayi Muscle positioning protein 4 0.0035 0.0079 0.0039
Schistosoma mansoni histamine h1 receptor 0.0253 0.1328 0.1309
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0209 0.1077 0.4012
Brugia malayi Nuclear hormone receptor-like 1 0.014 0.0679 0.0642
Schistosoma mansoni coup transcription factor 0.014 0.0679 0.0658
Schistosoma mansoni cell polarity protein 0.0035 0.0079 0.0057
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0253 0.1328 0.1328
Echinococcus multilocularis 0.0029 0.0043 0.0054
Echinococcus multilocularis fibropellin Ia 0.0035 0.0079 0.01
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Onchocerca volvulus 0.0035 0.0079 0.0138
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Loa Loa (eye worm) melatonin receptor type 1A 0.0253 0.1328 0.1314
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Schistosoma mansoni opsin-like receptor 0.0253 0.1328 0.1309
Echinococcus granulosus short transient receptor potential channel 6 0.0034 0.0072 0.0072
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Echinococcus multilocularis geminin 0.0181 0.0916 0.116
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0287 0.1053
Schistosoma mansoni hypothetical protein 0.0253 0.1328 0.1309
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0167
Brugia malayi larval opioid receptor 0.0253 0.1328 0.1294
Echinococcus granulosus fmrfamide receptor 0.0253 0.1328 0.1328
Brugia malayi Dopamine receptor protein 2 0.0253 0.1328 0.1294
Schistosoma mansoni egf-like domain protein 0.0053 0.0183 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-41 0.014 0.0679 0.0642
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0209 0.1077 0.1063
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0253 0.1328 0.1309
Echinococcus granulosus tm gpcr rhodopsin 0.0253 0.1328 0.1328
Leishmania major peptidyl-prolyl cis-trans isomerase, macrophage infectivity potentiator precursor, putative 0.0029 0.0043 0.0125
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Trypanosoma cruzi PAB1-binding protein , putative 0.0101 0.0459 0.1707
Echinococcus granulosus potassium voltage gated channel subfamily D 0.0073 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0028 0.0041 0.0024
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0053 0.0183 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.014 0.0679 0.0664
Onchocerca volvulus 0.01 0.0452 0.1574
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0028 0.004 0.004
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.009 0.0396 0.0501
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.0671 0.0671
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0035 0.0079 0.0138
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0209 0.1077 0.2024
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Loa Loa (eye worm) hypothetical protein 0.0187 0.0952 0.0937
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0253 0.1328 0.1681
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0046 0.0139 0.0175
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0187 0.0952 0.0932
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Entamoeba histolytica hypothetical protein 0.0056 0.02 0.1241
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0039 0.0103 0.0081
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0034 0.0072 0.005
Brugia malayi Bromodomain containing protein 0.0083 0.0355 0.0317
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0048 0.0153 0.0194
Echinococcus multilocularis glutamate receptor 2 0.0048 0.0153 0.0194
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0066 0.0256 0.0324
Schistosoma mansoni hypothetical protein 0.0304 0.1618 0.1599
Echinococcus multilocularis Mastin 0.0252 0.1321 0.1671
Echinococcus granulosus enteropeptidase 0.0252 0.1321 0.1321
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0287 0.0997
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.009 0.0396 0.0396
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Mycobacterium ulcerans lipase LipD 0.0071 0.0287 0.2359
Brugia malayi Nuclear hormone receptor family member nhr-1 0.014 0.0679 0.0642
Loa Loa (eye worm) trypsin family protein 0.01 0.0452 0.0436
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.0671 0.0656
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0327 0.1748 0.1748
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.009 0.0396 0.0501
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0035 0.0079 0.0057
Mycobacterium leprae Probable lipase LipE 0.0071 0.0287 0.3777
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0253 0.1328 0.1681
Onchocerca volvulus Neurogenic locus notch homolog 0.0035 0.0079 0.0138
Echinococcus granulosus neurogenic locus notch protein 0.0035 0.0079 0.0079
Giardia lamblia Kinase, PLK 0.0098 0.0439 0.1534
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0144 0.039
Brugia malayi Glutamate receptor 2 precursor 0.004 0.0109 0.007
Schistosoma mansoni Tr4/Tr2 (homologue) 0.014 0.0679 0.0658
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0048 0.0153 0.0194
Schistosoma mansoni amine GPCR 0.0253 0.1328 0.1309
Schistosoma mansoni voltage-gated potassium channel 0.0073 0.0296 0.0275
Echinococcus multilocularis 0.1361 0.7674 0.9711
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0253 0.1328 0.1309
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.01 0.0452 0.0431
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.014 0.0679 0.2448
Onchocerca volvulus 0.0253 0.1328 0.4947
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0043 0.002
Brugia malayi ORL1-like opioid receptor 0.0253 0.1328 0.1294
Giardia lamblia High cysteine protein 0.0035 0.0079 0.0139
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Leishmania major FKBP-type peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0125
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0008
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0577 0.3186 0.6022
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni neuropeptide F-like receptor 0.0253 0.1328 0.1309
Onchocerca volvulus 0.0253 0.1328 0.4947
Brugia malayi putative neuropeptide receptor NPR1 0.0253 0.1328 0.1294
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0034 0.0072 0.0072
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.009 0.0396 0.0396
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.01 0.0452 0.0452
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0039 0.0103 0.0352
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0086
Schistosoma mansoni notch 0.0035 0.0079 0.0057
Loa Loa (eye worm) hypothetical protein 0.0286 0.1517 0.1503
Schistosoma mansoni hypothetical protein 0.0028 0.004 0.0017
Echinococcus multilocularis fk506 binding protein 0.0209 0.1077 0.1364
Onchocerca volvulus Transient receptor potential cation channel trpm homolog 0.0034 0.0072 0.0111
Echinococcus granulosus geminin 0.0181 0.0916 0.0916
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.0439 0.0813
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0442 0.082
Trypanosoma cruzi subtilisin peptidase 0.0099 0.0442 0.1643
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0072 0.0091
Schistosoma mansoni hypothetical protein 0.0253 0.1328 0.1309
Trypanosoma cruzi serine peptidase, clan SB, family S8-like protein 0.0099 0.0442 0.1643
Schistosoma mansoni neuropeptide receptor 0.0253 0.1328 0.1309
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.014 0.0679 0.0664
Onchocerca volvulus Neuropeptide F receptor homolog 0.0253 0.1328 0.4947
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.0671 0.085
Brugia malayi Hypothetical subtilase-type proteinase F21H12.6 in chromosome II 0.0099 0.0442 0.0404
Loa Loa (eye worm) notch protein 0.0035 0.0079 0.0062
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis shaker cognate 0.0073 0.0296 0.0375
Onchocerca volvulus 0.0039 0.0103 0.0229
Echinococcus granulosus glutamate receptor 2 0.0048 0.0153 0.0153
Mycobacterium ulcerans membrane-anchored serine protease (mycosin), MycP4 0.0099 0.0442 0.386
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.0439 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-49 0.014 0.0679 0.0642
Onchocerca volvulus 0.0071 0.0287 0.0939
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0215
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0039 0.0103 0.0352
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Echinococcus multilocularis potassium voltage gated channel protein 0.0034 0.0072 0.0091
Toxoplasma gondii calcium binding egf domain-containing protein 0.0053 0.0183 0.0547
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0053 0.0183 0.0167
Loa Loa (eye worm) hypothetical protein 0.0071 0.0287 0.0271
Brugia malayi photoreceptor-specific nuclear receptor 0.014 0.0679 0.0642
Mycobacterium tuberculosis Probable alanine and proline rich membrane-anchored mycosin MycP2 (serine protease) (subtilisin-like protease) (subtilase-like) 0.0099 0.0442 0.163
Trypanosoma brucei btb/poz domain containing protein, putative 0.0039 0.0103 0.0596
Echinococcus granulosus neuropeptides capa receptor 0.0253 0.1328 0.1328
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Brugia malayi Nuclear hormone receptor family member nhr-3 0.014 0.0679 0.0642
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus granulosus neuropeptide FF receptor 2 0.0253 0.1328 0.1328
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0253 0.1328 0.1681
Schistosoma mansoni glutamate receptor NMDA 0.004 0.0109 0.0087
Echinococcus multilocularis serotonin receptor 0.0253 0.1328 0.1681
Brugia malayi Voltage-gated calcium channel, alpha subunit 0.0034 0.0072 0.0032
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0253 0.1328 0.1309
Onchocerca volvulus 0.0039 0.0103 0.0229
Echinococcus granulosus nuclear receptor 2DBD gamma 0.014 0.0679 0.0679
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.1767 1 1
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0287 0.3777
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0209 0.1077 0.4057
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0944 0.5283 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0034 0.0072 0.0091
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Leishmania major potassium voltage-gated channel, putative 0.0039 0.0103 0.0352
Brugia malayi Nuclear hormone receptor family member nhr-40 0.014 0.0679 0.0642
Loa Loa (eye worm) hypothetical protein 0.0037 0.0092 0.0076
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Mycobacterium ulcerans membrane-anchored mycosin MycP3 0.0099 0.0442 0.386
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0181 0.0181
Echinococcus multilocularis neural cadherin 0.0035 0.0079 0.01
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.0371 0.0685
Brugia malayi Delta serrate ligand family protein 0.0035 0.0079 0.0039
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0253 0.1328 0.1681
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0072 0.005
Trypanosoma brucei serine peptidase, clan SB, family S8-like protein 0.0099 0.0442 0.3872
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni nuclear receptor 0.0066 0.0256 0.0234
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0253 0.1328 0.1309
Brugia malayi ion channel NompC 0.0034 0.0072 0.0032
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0209 0.1077 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0287 0.0997
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0442 0.082
Echinococcus granulosus sex peptide receptor 0.0253 0.1328 0.1328
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus zinc finger protein 0.0029 0.0046 0.0046
Toxoplasma gondii subtilisin SUB4 0.0099 0.0442 0.1544
Schistosoma mansoni growth hormone secretagogue receptor 0.0253 0.1328 0.1309
Echinococcus granulosus BTB:POZ domain containing protein 0.0039 0.0103 0.0103
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) hypothetical protein 0.01 0.0452 0.0436
Echinococcus multilocularis inhibitor of apoptosis protein 0.0327 0.1748 0.2213
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Loa Loa (eye worm) ion channel NompC 0.0034 0.0072 0.0055
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0074 0.0301 0.0381
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0253 0.1328 0.1328
Echinococcus multilocularis voltage gated potassium channel 0.0073 0.0296 0.0375
Brugia malayi RNA, U transporter 1 0.0081 0.0341 0.0303
Echinococcus multilocularis slit 2 protein 0.0035 0.0079 0.01
Echinococcus multilocularis FK506 binding protein 8, 38 kDa 0.0029 0.0043 0.0054
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0203 0.104 0.1025
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.014 0.0679 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0253 0.1328 0.1294
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.014 0.0679 0.0664
Echinococcus multilocularis two pore calcium channel protein 2 0.0034 0.0072 0.0091
Echinococcus granulosus dnaJ subfamily B 0.0405 0.2196 0.2196
Schistosoma mansoni cercarial elastase (S01 family) 0.01 0.0452 0.0431
Loa Loa (eye worm) nuclear hormone receptor 0.0066 0.0256 0.024
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0029 0.0043 0.0008
Echinococcus granulosus g-protein coupled receptor 0.0253 0.1328 0.1328
Chlamydia trachomatis peptidyl-prolyl cis-trans isomerase 0.0029 0.0043 0.5
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Echinococcus granulosus transient receptor potential cation channel 0.0034 0.0072 0.0072
Brugia malayi Large-conductance calcium-activated potassium channel Slo-1 (KCNMA) alpha subunit. C. elegans slo-1 ortholog 0.0034 0.0072 0.0032
Echinococcus granulosus FK506 binding protein 8 38 kDa 0.0029 0.0043 0.0043
Echinococcus multilocularis g-protein coupled receptor 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Entamoeba histolytica acetyltransferase, GNAT family 0.0077 0.0318 0.2015
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0577 0.3186 0.6022
Schistosoma mansoni hypothetical protein 0.0056 0.02 0.0178
Plasmodium falciparum kelch protein K13 0.0039 0.0103 0.0237
Trichomonas vaginalis esterase, putative 0.0071 0.0287 0.0525
Schistosoma mansoni hypothetical protein 0.0482 0.2641 0.2625
Brugia malayi Nuclear hormone receptor family member nhr-25 0.014 0.0679 0.0642
Schistosoma mansoni notch 0.0035 0.0079 0.0057
Loa Loa (eye worm) hypothetical protein 0.0074 0.0301 0.0285
Echinococcus multilocularis neuroendocrine convertase 2 0.1401 0.7902 1
Echinococcus granulosus FK506 binding protein 2 0.0029 0.0043 0.0043
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0034 0.0072 0.0032
Trypanosoma cruzi subtilisin-like serine peptidase, putative 0.0099 0.0442 0.1643
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Trichomonas vaginalis hypothetical protein 0.0406 0.2204 0.416
Schistosoma mansoni hypothetical protein 0.0028 0.004 0.0017
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0125
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0144 0.0144
Leishmania major hypothetical protein, conserved 0.0101 0.0459 0.1707
Brugia malayi conserved hypotetical protein 0.0066 0.0256 0.0217
Onchocerca volvulus 0.0035 0.0079 0.0138
Brugia malayi RE15519p 0.0253 0.1328 0.1294
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0577 0.3186 0.6022
Brugia malayi Fibulin-1 precursor 0.0053 0.0183 0.0144
Loa Loa (eye worm) voltage-gated calcium channel 0.0034 0.0072 0.0055
Loa Loa (eye worm) potassium channel tetramerisation domain containing 3 0.0039 0.0103 0.0086
Echinococcus granulosus biogenic amine 5HT receptor 0.0253 0.1328 0.1328
Echinococcus granulosus short transient receptor potential channel 6 0.0034 0.0072 0.0072
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0253 0.1328 0.1681
Echinococcus multilocularis G-protein coupled receptor, putative 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0327 0.1748 0.1735
Schistosoma mansoni glutamate receptor kainate 0.004 0.0109 0.0087
Echinococcus granulosus snurportin 1 0.0304 0.1618 0.1618
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0074 0.0301 0.028
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.0439 0.0555
Trichomonas vaginalis conserved hypothetical protein 0.0099 0.0442 0.082
Loa Loa (eye worm) hypothetical protein 0.0071 0.0287 0.0271
Trichomonas vaginalis fk506 binding protein, putative 0.0029 0.0043 0.0062
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0072 0.0091
Echinococcus granulosus Furin 1 0.0577 0.3186 0.3186
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0066 0.0256 0.0256
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0287 0.1524 0.1929
Brugia malayi Nuclear hormone receptor family member nhr-25 0.014 0.0679 0.0642
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0034 0.0072 0.0119
Echinococcus granulosus GPCR family 2 0.0028 0.004 0.004
Echinococcus granulosus tm gpcr rhodopsin 0.0253 0.1328 0.1328
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0091
Schistosoma mansoni notch 0.0035 0.0079 0.0057
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0066 0.0256 0.024
Echinococcus multilocularis sex peptide receptor 0.0253 0.1328 0.1681
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.014 0.0679 0.0664
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0482 0.2641 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0146 0.0146
Toxoplasma gondii subtilisin SUB5 0.0099 0.0442 0.1544
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Loa Loa (eye worm) K+ channel tetramerisation domain-containing protein 0.0039 0.0103 0.0086
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0253 0.1328 0.1681
Brugia malayi Melatonin receptor type 1A 0.0253 0.1328 0.1294
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0253 0.1328 0.1681
Brugia malayi Pre-SET motif family protein 0.0203 0.104 0.1005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0034 0.0072 0.0032
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.0439 0.2804
Plasmodium vivax peptidyl-prolyl cis-trans isomerase, putative 0.0029 0.0043 0.0008
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.014 0.0679 0.0642
Echinococcus multilocularis ryanodine receptor 44f 0.0034 0.0072 0.0091
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-13 0.0029 0.0043 0.0026
Echinococcus granulosus tachykinin peptides receptor 99D 0.0253 0.1328 0.1328
Schistosoma mansoni opsin-like receptor 0.0253 0.1328 0.1309
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Echinococcus multilocularis transient receptor potential cation channel 0.0034 0.0072 0.0091
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0859 0.4797 0.6071
Brugia malayi Cytochrome P450 family protein 0.0048 0.0152 0.0113
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0072 0.0072
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0034 0.0072 0.0072
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0053 0.0183 0.0161
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Onchocerca volvulus 0.0482 0.2641 1
Schistosoma mansoni cyclic-nucleotide-gated cation channel 0.0034 0.0072 0.005
Echinococcus multilocularis laminin 0.0053 0.0183 0.0232
Schistosoma mansoni voltage-gated potassium channel 0.0034 0.0072 0.005
Echinococcus multilocularis short transient receptor potential channel 6 0.0034 0.0072 0.0091
Brugia malayi ecdysteroid receptor 0.014 0.0679 0.0642
Echinococcus granulosus orexin receptor type 2 0.0253 0.1328 0.1328
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.2492 1
Leishmania major hypothetical protein, conserved 0.0071 0.0287 0.1053
Onchocerca volvulus 0.0035 0.0079 0.0138
Echinococcus multilocularis Tolloid protein 1 0.0053 0.0183 0.0232
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Schistosoma mansoni hypothetical protein 0.0253 0.1328 0.1309
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni RAR-like nuclear receptor 0.014 0.0679 0.0658
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.014 0.0679 0.0859
Schistosoma mansoni cpg binding protein 0.0061 0.023 0.0208
Brugia malayi Calcitonin receptor-like protein seb-1 0.0089 0.0389 0.0351
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Brugia malayi Calcium binding EGF domain containing protein 0.0053 0.0183 0.0144
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0034 0.0072 0.0072
Echinococcus multilocularis ecdysone induced protein 78C 0.014 0.0679 0.0859
Schistosoma mansoni notch 0.0035 0.0079 0.0057
Brugia malayi nuclear receptor NHR-88 0.014 0.0679 0.0642
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus granulosus neural cadherin 0.0035 0.0079 0.0079
Echinococcus multilocularis neuropeptides capa receptor 0.0253 0.1328 0.1681
Echinococcus multilocularis potassium voltage gated channel protein 0.0073 0.0296 0.0375
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0577 0.3186 0.6022
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0144 0.0182
Brugia malayi Protein kinase domain containing protein 0.0482 0.2641 0.2612
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Echinococcus multilocularis neuropeptide Y receptor 0.0253 0.1328 0.1681
Schistosoma mansoni slit 0.0035 0.0079 0.0057
Brugia malayi Muscleblind-like protein 0.0286 0.1517 0.1483
Brugia malayi olfactory channel protein osm-9 0.0034 0.0072 0.0032
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Echinococcus granulosus ryanodine receptor 44f 0.0034 0.0072 0.0072
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0287 0.1053
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0034 0.0072 0.0298
Onchocerca volvulus 0.0073 0.0296 0.0974
Loa Loa (eye worm) steroid hormone receptor 0.014 0.0679 0.0664
Schistosoma mansoni neuropeptide receptor 0.0253 0.1328 0.1309
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.014 0.0679 0.0658
Schistosoma mansoni hyperpolarization activated cyclic nucleotide-gated potassium channel 0.0034 0.0072 0.005
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0327 0.1748 0.1716
Schistosoma mansoni voltage-gated potassium channel 0.0898 0.5022 0.5011
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0209 0.1077 0.4057
Toxoplasma gondii hypothetical protein 0.0034 0.0072 0.0119
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0256 0.024
Echinococcus multilocularis neurogenic locus notch protein 0.0035 0.0079 0.01
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0253 0.1328 0.1681
Trichomonas vaginalis conserved hypothetical protein 0.0406 0.2204 0.416
Echinococcus granulosus rhodopsin orphan GPCR 0.0253 0.1328 0.1328
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Echinococcus granulosus neuropeptide Y receptor 0.0253 0.1328 0.1328
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.0671 0.0651
Onchocerca volvulus 0.0066 0.0256 0.0819
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.029 0.1539 1
Schistosoma mansoni kinase 0.005 0.0163 0.0141
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus TRP transient receptor potential channel 0.0034 0.0072 0.0072
Mycobacterium tuberculosis Probable membrane-anchored mycosin MycP4 (serine protease) (subtilisin-like protease) (subtilase-like) (mycosin-4) 0.0099 0.0442 0.163
Onchocerca volvulus 0.0253 0.1328 0.4947
Brugia malayi Trypsin family protein 0.0187 0.0952 0.0916
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0253 0.1328 0.1328
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0074 0.0301 0.0301
Echinococcus granulosus neurogenic locus notch protein 4 0.0035 0.0079 0.0079
Mycobacterium ulcerans beta-lactamase 0.0071 0.0287 0.2359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Loa Loa (eye worm) hypothetical protein 0.014 0.0679 0.0664
Brugia malayi voltage-dependent calcium channel 0.0034 0.0072 0.0032
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0034 0.0072 0.0072
Schistosoma mansoni hypothetical protein 0.0143 0.0698 0.0678
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Echinococcus multilocularis voltage dependent calcium channel 0.0034 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) beta-lactamase 0.0071 0.0287 0.0271
Echinococcus granulosus protein jagged 2 0.0035 0.0079 0.0079
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0253 0.1328 0.1309
Schistosoma mansoni vesicular amine transporter 0.0073 0.0296 0.0275
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus ecdysone induced protein 78C 0.014 0.0679 0.0679
Plasmodium falciparum ataxin-2 like protein, putative 0.0101 0.0459 0.1609
Onchocerca volvulus 0.0035 0.0079 0.0138
Plasmodium vivax subtilisin-like protease 1 0.0099 0.0442 0.1544
Brugia malayi MH2 domain containing protein 0.012 0.0564 0.0527
Echinococcus multilocularis fmrfamide receptor 0.0253 0.1328 0.1681
Loa Loa (eye worm) hypothetical protein 0.0074 0.0301 0.0285
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0287 0.0997
Leishmania major hypothetical protein, unknown function 0.0034 0.0072 0.0235
Loa Loa (eye worm) endoprotease bli-4 0.1767 1 1
Trypanosoma brucei inositol 1,4,5-trisphosphate receptor 0.0034 0.0072 0.0298
Onchocerca volvulus Bile acid receptor homolog 0.014 0.0679 0.2448
Echinococcus multilocularis Furin 1 0.0577 0.3186 0.4031
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.009 0.0396 0.038
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0253 0.1328 0.1328
Brugia malayi hypothetical protein 0.0066 0.0256 0.0217
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.3846 0.3833
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.01 0.0452 0.0452
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit 0.0034 0.0072 0.0032
Brugia malayi GnHR receptor homolog 0.0253 0.1328 0.1294
Echinococcus multilocularis serotonin receptor 0.0253 0.1328 0.1681
Toxoplasma gondii LsmAD domain-containing protein 0.0101 0.0459 0.1609
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0253 0.1328 0.1309
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0287 0.0997
Echinococcus multilocularis membrane bound transcription factor site 1 0.0099 0.0442 0.056
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0577 0.3186 0.3171
Schistosoma mansoni hypothetical protein 0.0034 0.0072 0.005
Echinococcus granulosus potassium voltage gated channel protein 0.0073 0.0296 0.0296
Loa Loa (eye worm) hypothetical protein 0.0053 0.0183 0.0167
Brugia malayi hypothetical protein 0.0253 0.1328 0.1294
Echinococcus granulosus calcium activated potassium channel 0.0034 0.0074 0.0074
Loa Loa (eye worm) hypothetical protein 0.0071 0.0287 0.0271
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0146 0.0124
Brugia malayi Dopamine receptor protein 1 0.0253 0.1328 0.1294
Echinococcus multilocularis muscleblind protein 1 0.0286 0.1517 0.192
Schistosoma mansoni nuclear receptor nhr-48 0.0066 0.0256 0.0234
Trichomonas vaginalis set domain proteins, putative 0.0231 0.12 0.2256
Schistosoma mansoni transient receptor potential cation channel subfamily m member 0.0034 0.0072 0.005
Leishmania major subtilisin-like serine peptidase 0.0099 0.0442 0.1643
Schistosoma mansoni tyrosine kinase 0.0313 0.1673 0.1654
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni voltage-gated ion channel 0.0034 0.0072 0.005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0287 0.0265
Loa Loa (eye worm) hypothetical protein 0.0071 0.0287 0.0271
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Toxoplasma gondii EGF family domain-containing protein 0.0035 0.0079 0.0146
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0056 0.02 0.0253
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0072 0.0117
Loa Loa (eye worm) neuropeptide F receptor 0.0253 0.1328 0.1314
Brugia malayi nuclear receptor NHR-88 0.0066 0.0256 0.0217
Loa Loa (eye worm) hypothetical protein 0.0046 0.0144 0.0128
Entamoeba histolytica hypothetical protein 0.0056 0.02 0.1241
Echinococcus granulosus protein jagged 2 0.0035 0.0079 0.0079
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Echinococcus multilocularis voltage gated hydrogen channel 1 0.0034 0.0072 0.0091
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Toxoplasma gondii subtilisin SUB11 0.0099 0.0442 0.1544
Schistosoma mansoni transient receptor potential channel 0.0034 0.0072 0.005
Brugia malayi cation channel family protein 0.0034 0.0072 0.0032
Schistosoma mansoni voltage-gated potassium channel 0.0898 0.5022 0.5011
Loa Loa (eye worm) hypothetical protein 0.0053 0.0181 0.0165
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0034 0.0072 0.0072
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0034 0.0072 0.0091
Leishmania major hypothetical protein, conserved 0.0482 0.2641 1
Echinococcus multilocularis fat cadherin tumor suppressor 0.0035 0.0079 0.01
Schistosoma mansoni hypothetical protein 0.0035 0.0079 0.0057
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0452 0.0431
Entamoeba histolytica hypothetical protein 0.0056 0.02 0.1241
Toxoplasma gondii peptidyl-prolyl cis-trans isomerase, FKBP-type domain-containing protein 0.0029 0.0043 0.0008
Echinococcus granulosus potassium voltage gated channel protein 0.0034 0.0072 0.0072
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-30 0.0029 0.0043 0.0026
Echinococcus granulosus neuropeptide receptor 0.0253 0.1328 0.1328
Onchocerca volvulus 0.0253 0.1328 0.4947
Loa Loa (eye worm) hypothetical protein 0.0071 0.0287 0.0271
Mycobacterium leprae PROBABLE MEMBRANE-ANCHORED MYCOSIN MYCP3 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-3) 0.0099 0.0442 0.6179
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0287 0.0525
Echinococcus granulosus epidermal growth factor receptor 0.0313 0.1673 0.1673
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Echinococcus granulosus voltage gated potassium channel 0.0034 0.0072 0.0072
Echinococcus granulosus voltage gated hydrogen channel 1 0.0034 0.0072 0.0072
Loa Loa (eye worm) MBCTL1 0.0053 0.0181 0.0165
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.0671 0.0634
Echinococcus multilocularis neuropeptide receptor A26 0.0253 0.1328 0.1681
Brugia malayi hypothetical protein 0.0034 0.0072 0.0032
Brugia malayi nuclear hormone receptor 0.014 0.0679 0.0642
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0043 0.0062
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0039 0.0103 0.0352
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0066 0.0256 0.024
Schistosoma mansoni hypothetical protein 0.0046 0.0139 0.0117
Onchocerca volvulus 0.003 0.0051 0.003
Schistosoma mansoni immunophilin 0.0209 0.1077 0.1058
Echinococcus multilocularis potassium voltage gated channel protein 0.0073 0.0296 0.0375
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0201 0.0185
Brugia malayi hypothetical protein 0.0066 0.0256 0.0217
Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor, putative 0.0034 0.0072 0.0235
Echinococcus multilocularis protein jagged 1 0.0035 0.0079 0.01
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.0452 0.0431
Echinococcus multilocularis sodium leak channel non selective protein 0.0034 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Schistosoma mansoni opsin-like receptor 0.0253 0.1328 0.1309
Brugia malayi nuclear receptor RXR 0.0074 0.0301 0.0263
Echinococcus granulosus glutamate NMDA receptor subunit 0.004 0.0109 0.0109
Giardia lamblia High cysteine membrane protein Group 2 0.0439 0.2393 0.9114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0089 0.0389 0.0351
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0034 0.0072 0.0091
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-30, BmFKBP-30 0.0029 0.0043 0.0003
Onchocerca volvulus Arrow homolog 0.0053 0.0183 0.0539
Trypanosoma brucei btb/poz domain containing protein, putative 0.0039 0.0103 0.0596
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.014 0.0679 0.0658
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0039 0.0103 0.0352
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0181 0.0181
Echinococcus granulosus neuropeptide s receptor 0.0253 0.1328 0.1328
Echinococcus granulosus allatostatin A receptor 0.0253 0.1328 0.1328
Trypanosoma brucei polo-like protein kinase 0.0098 0.0439 0.3837
Loa Loa (eye worm) hypothetical protein 0.0034 0.0072 0.0055
Toxoplasma gondii calcium binding egf domain-containing protein 0.0053 0.0183 0.0547
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.0546 0.0691
Onchocerca volvulus 0.0039 0.0103 0.0229
Echinococcus multilocularis potassium voltage gated channel subfamily D 0.0073 0.0296 0.0375
Loa Loa (eye worm) hypothetical protein 0.0039 0.0103 0.0086
Echinococcus granulosus protein jagged 1 0.0035 0.0079 0.0079
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0186 0.0943 0.1193
Brugia malayi acetyltransferase, GNAT family protein 0.0287 0.1524 0.1491
Onchocerca volvulus 0.0327 0.1748 0.6564
Schistosoma mansoni zinc finger protein 0.0029 0.0046 0.0023
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0209 0.1077 1
Echinococcus multilocularis zinc finger protein 0.0029 0.0046 0.0058
Brugia malayi Pre-SET motif family protein 0.003 0.0051 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0253 0.1328 0.1681
Onchocerca volvulus 0.0253 0.1328 0.4947
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0144 0.0122
Loa Loa (eye worm) acetyltransferase 0.0287 0.1524 0.151
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0253 0.1328 0.1309
Mycobacterium ulcerans proline rich membrane-anchored mycosin MycP5 0.0099 0.0442 0.386
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0074 0.0301 0.0285
Echinococcus multilocularis notch 0.0035 0.0079 0.01
Echinococcus multilocularis tissue type plasminogen activator 0.0482 0.2641 0.3342
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0287 0.2359
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Brugia malayi EGF-like domain containing protein 0.0035 0.0079 0.0039
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0099 0.0442 0.082
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0287 0.0287
Echinococcus granulosus potassium voltage gated channel subfamily C 0.0073 0.0296 0.0296
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0144 0.0122
Brugia malayi jmjC domain containing protein 0.0066 0.0256 0.0217
Brugia malayi Furin-like cysteine rich region family protein 0.0313 0.1673 0.164
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0253 0.1328 0.1309
Echinococcus multilocularis transfer RNA-Gly 0.0073 0.0296 0.0375
Loa Loa (eye worm) hypothetical protein 0.0253 0.1328 0.1314
Echinococcus multilocularis transmembrane protease serine 3 0.01 0.0452 0.0572
Schistosoma mansoni inhibitor of apoptosis protein 0.0327 0.1748 0.173
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0209 0.1077 0.1077
Loa Loa (eye worm) hypothetical protein 0.0035 0.0079 0.0062
Echinococcus multilocularis hyperpolarization activated cyclic 0.0034 0.0072 0.0091
Loa Loa (eye worm) hypothetical protein 0.01 0.0452 0.0436
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.029 0.1539 0.2899
Brugia malayi Voltage-gated potassium channel, Shaw-family (KCNC, Kv3-like) alpha-subunit. C. elegans egl-36 ortholog 0.0034 0.0072 0.0032
Plasmodium falciparum subtilisin-like protease 1 0.0099 0.0442 0.1544
Trypanosoma cruzi btb/poz domain containing protein, putative 0.0039 0.0103 0.0352
Loa Loa (eye worm) hypothetical protein 0.0099 0.0442 0.0426
Brugia malayi notch-like transmembrane receptor 0.0035 0.0079 0.0039
Schistosoma mansoni notch 0.0035 0.0079 0.0057

Activities

Activity type Activity value Assay description Source Reference
EC50 (functional) = 122 uM Effective concentration forskolin-stimulated cAMP formation in BHK cells expressing mGluR2 receptor ChEMBL. 8667369
EC50 (functional) > 300 uM Concentration required for the half-maximal inhibition of cAMP formation in BHK cells expressing mGluR2 ChEMBL. 8667369
EC50 (functional) > 300 uM Concentration required for the half-maximal inhibition of cAMP formation in BHK cells expressing mGluR4 ChEMBL. 8667369
IC50 (functional) > 300 uM Concentration required for the half-maximal inhibition of PI hydrolysis in BHK cells expressing mGluR1a ChEMBL. 8667369
IC50 (functional) > 300 uM Concentration required for the half-maximal inhibition of cAMP formation in BHK cells expressing mGluR4 ChEMBL. 8667369
Ki (binding) = 15 uM Binding affinity towards Ionotropic glutamate receptor kainate ChEMBL. 8667369
Ki (binding) = 125 uM Binding affinity towards Ionotropic glutamate receptor AMPA ChEMBL. 8667369
Ki (binding) = 129 uM Binding affinity towards Ionotropic glutamate receptor NMDA ChEMBL. 8667369
Ki (binding) = 135 uM Binding affinity towards metabotropic glutamate receptor mGluR1 ChEMBL. 8667369
Ki (binding) > 280 uM Binding affinity of the compound towards metabotropic glutamate receptor mGluR4a ChEMBL. 8667369

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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