Detailed information for compound 1775328

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 661.915 | Formula: C43H55N3O3
  • H donors: 0 H acceptors: 4 LogP: 9.56 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: C[C@@H]1CC[C@]2([C@@H]([C@H]1C)C1=CC[C@H]3[C@@]([C@@]1(CC2)C)(C)CC[C@@H]1[C@]3(C)CCC(=O)C1(C)C)C(=O)OCc1nnn(c1)c1cccc2c1cccc2
  • InChi: 1S/C43H55N3O3/c1-27-17-22-43(38(48)49-26-30-25-46(45-44-30)33-14-10-12-29-11-8-9-13-31(29)33)24-23-41(6)32(37(43)28(27)2)15-16-35-40(5)20-19-36(47)39(3,4)34(40)18-21-42(35,41)7/h8-15,25,27-28,34-35,37H,16-24,26H2,1-7H3/t27-,28+,34+,35-,37+,40+,41-,42-,43+/m1/s1
  • InChiKey: BEVKUSMPNFNZIG-HFQYITBFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ecdysteroid receptor 0.0042 0.0063 0.0219
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0046 0.0078 0.0076
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0007 0.0018
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.016 0.0471 0.048
Schistosoma mansoni myst-related protein 0.003 0.0022 0.0022
Mycobacterium ulcerans glutaminase 0.0824 0.2771 0.2881
Schistosoma mansoni alkaline phosphatase 0.0164 0.0485 0.0485
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0036 0.0081
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0174 0.0419
Trypanosoma cruzi hypothetical protein, conserved 0.0109 0.0295 0.0709
Trypanosoma brucei metacaspase MCA3 0.0026 0.0007 0.0012
Onchocerca volvulus 0.0063 0.0138 0.0878
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0108 0.0294 0.0292
Echinococcus granulosus heat shock protein 0.0034 0.0036 0.0034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0063 0.0066
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0107 0.029 0.1655
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.029 0.0692
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Echinococcus multilocularis cpg binding protein 0.0254 0.0799 0.0797
Loa Loa (eye worm) latrophilin receptor protein 2 0.0207 0.0635 0.0662
Trypanosoma cruzi DNA polymerase eta, putative 0.0122 0.0342 0.0821
Schistosoma mansoni bromodomain containing protein 0.0206 0.0632 0.0632
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0046 0.0078 0.0076
Echinococcus granulosus bloom syndrome protein 0.0112 0.0305 0.0303
Schistosoma mansoni hypothetical protein 0.0334 0.1074 0.1074
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0095 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0174 0.0621
Mycobacterium ulcerans hypothetical protein 0.0074 0.0174 0.017
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0063 0.0063
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0189 0.0571 0.1372
Schistosoma mansoni endoplasmin 0.0034 0.0036 0.0036
Loa Loa (eye worm) mbt repeat family protein 0.0052 0.0098 0.0102
Schistosoma mansoni ferritin light chain 0.0035 0.004 0.004
Onchocerca volvulus Ceramide kinase 1 homolog 0.0109 0.0295 0.1893
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0063 0.0061
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0005 0.0007
Onchocerca volvulus 0.0052 0.0098 0.0618
Leishmania major hypothetical protein, conserved 0.0109 0.0295 0.0704
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0074 0.0176 0.0172
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0011 0.0068
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0061
Schistosoma mansoni ap endonuclease 0.0097 0.0253 0.0253
Schistosoma mansoni cpg binding protein 0.0237 0.0738 0.0738
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0107 0.029 0.0697
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0076 0.0176
Schistosoma mansoni hypothetical protein 0.0046 0.0078 0.0078
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.1097
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0174 0.017
Schistosoma mansoni apoferritin-2 0.0035 0.004 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0207 0.0635 0.0633
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0007 0.0018
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0046 0.0078 0.0076
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0115 0.0113
Echinococcus granulosus expressed protein 0.0034 0.0035 0.0033
Brugia malayi latrophilin 2 splice variant baaae 0.0447 0.1466 0.5287
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0063 0.0219
Loa Loa (eye worm) hypothetical protein 0.0037 0.0047 0.0049
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0188 0.1109
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0176 0.0172
Brugia malayi Bromodomain containing protein 0.0039 0.0053 0.0183
Echinococcus multilocularis transcription factor Dp 1 0.0115 0.0318 0.0316
Trichomonas vaginalis dullard protein, putative 0.0025 0.0005 0.001
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0146 0.0425 0.0422
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.029 0.0303
Giardia lamblia Heat shock protein HSP 90-alpha 0.0027 0.0012 0.0057
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0065 0.0145 0.0143
Mycobacterium tuberculosis Conserved hypothetical protein 0.0146 0.0425 0.0431
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0109 0.0295 0.174
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0109 0.0295 0.0295
Mycobacterium ulcerans hypothetical protein 0.0045 0.0076 0.0066
Echinococcus multilocularis zinc finger protein 0.0074 0.0176 0.0173
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0189 0.0571 0.1372
Trichomonas vaginalis glutaminase, putative 0.0824 0.2771 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0199 0.0608 0.1461
Schistosoma mansoni myelin transcription factor 1 myt1 0.0059 0.0122 0.0122
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.0613 0.1474
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0174 0.0621
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.1046
Trypanosoma brucei DNA polymerase kappa, putative 0.016 0.0471 0.1128
Trypanosoma cruzi metacaspase, putative 0.0026 0.0007 0.0018
Echinococcus granulosus polycomb protein SCMH1 0.0052 0.0098 0.0095
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Loa Loa (eye worm) hypothetical protein 0.0654 0.2182 0.2276
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0146 0.0425 0.0422
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0109 0.0295 0.0295
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0034 0.0035 0.0036
Entamoeba histolytica hypothetical protein 0.0146 0.0424 0.0442
Mycobacterium tuberculosis Conserved hypothetical protein 0.0646 0.2154 0.2237
Mycobacterium ulcerans hypothetical protein 0.0646 0.2154 0.2237
Loa Loa (eye worm) hypothetical protein 0.0128 0.0361 0.0376
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.0027 0.0011 0.0011
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0074 0.0174 0.0182
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0005 0.0005
Brugia malayi Endoplasmin precursor 0.0034 0.0036 0.0121
Mycobacterium ulcerans hypothetical protein 0.2794 0.9587 1
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0005 0.0016
Brugia malayi beta-lactamase family protein 0.0074 0.0174 0.0621
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0063 0.0394
Schistosoma mansoni hypothetical protein 0.0207 0.0635 0.0635
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0054 0.0052
Plasmodium vivax acyl-CoA synthetase, putative 0.0056 0.0111 0.0642
Leishmania major DNA polymerase kappa, putative 0.016 0.0471 0.1128
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0005 0.0016
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0415 0.1355 0.1413
Schistosoma mansoni hypothetical protein 0.0447 0.1466 0.1466
Trichomonas vaginalis diacylglycerol kinase, putative 0.0109 0.0295 0.1058
Mycobacterium tuberculosis Diacylglycerol kinase 0.0109 0.0295 0.0296
Plasmodium vivax endoplasmin, putative 0.0034 0.0036 0.0198
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0095 0.0497
Schistosoma mansoni myst-related protein 0.003 0.0022 0.0022
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0052 0.0098 0.0098
Brugia malayi Bromodomain containing protein 0.0242 0.0755 0.2717
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.0002 0.0005
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0016 0.0095
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0097 0.0253 0.0264
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0063 0.0061
Echinococcus multilocularis neuropeptide s receptor 0.0939 0.3168 0.3167
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0116
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0199 0.0608 0.0634
Trichomonas vaginalis bmru protein, putative 0.0109 0.0295 0.1058
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0078 0.0461
Brugia malayi acetyltransferase, GNAT family protein 0.015 0.0439 0.1577
Onchocerca volvulus Alhambra homolog 0.0028 0.0016 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Brugia malayi jmjC domain containing protein 0.0115 0.0318 0.1139
Echinococcus multilocularis disco interacting protein 2 0.004 0.0058 0.0056
Entamoeba histolytica diacylglycerol kinase, putative 0.0109 0.0295 0.0308
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0024
Trypanosoma brucei Metacaspase-4 0.0026 0.0007 0.0012
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0049 0.0089 0.0512
Schistosoma mansoni terminal deoxycytidyl transferase 0.0146 0.0425 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0063 0.0219
Schistosoma mansoni cpg binding protein 0.0254 0.0799 0.0799
Loa Loa (eye worm) hypothetical protein 0.029 0.0921 0.0961
Trypanosoma cruzi DNA damage repair protein, putative 0.0045 0.0076 0.0182
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0514 0.1696 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0053 0.0102 0.01
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0199 0.0608 0.1461
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0514 0.1696 1
Loa Loa (eye worm) hypothetical protein 0.0207 0.0635 0.0662
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Trichomonas vaginalis DNA helicase recq, putative 0.006 0.0125 0.0444
Onchocerca volvulus 0.0472 0.1551 1
Loa Loa (eye worm) MBCTL1 0.0059 0.0122 0.0128
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0078 0.0461
Loa Loa (eye worm) glutaminase 0.0824 0.2771 0.289
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0063 0.0061
Trypanosoma brucei DNA polymerase IV, putative 0.0201 0.0613 0.1469
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0019 0.0099
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0063 0.0061
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0076 0.018 0.105
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0176 0.0628
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0063 0.0394
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Schistosoma mansoni jumonji domain containing protein 0.0137 0.0393 0.0393
Echinococcus granulosus mixed lineage leukemia protein mll 0.0053 0.0102 0.01
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0097 0.0253 0.0264
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0514 0.1696 1
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0078 0.0274
Entamoeba histolytica diacylglycerol kinase, putative 0.0109 0.0295 0.0308
Brugia malayi beta-lactamase 0.0074 0.0174 0.0621
Leishmania major importin beta-1 subunit, putative 0.0024 0.0003 0.0002
Toxoplasma gondii heat shock protein HSP90 0.0034 0.0036 0.0211
Brugia malayi Disco-interacting protein 2 homolog 0.0037 0.0047 0.0163
Echinococcus granulosus zinc finger protein 0.0074 0.0176 0.0173
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0009 0.0021
Echinococcus multilocularis fetal alzheimer antigen, falz 0.008 0.0194 0.0192
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0023 0.0133
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0061
Loa Loa (eye worm) hypothetical protein 0.2794 0.9587 1
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0253 0.0905
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Trypanosoma brucei ISWI complex protein 0.0046 0.0078 0.0183
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0109 0.0295 0.0293
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0019 0.002
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0046 0.0078 0.0449
Schistosoma mansoni caspase-3 (C14 family) 0.0026 0.0007 0.0007
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Plasmodium vivax phosphoglycerate kinase, putative 0.0514 0.1696 1
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0063 0.0063
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0174 0.017
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0308
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0514 0.1696 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.012 0.0125
Echinococcus granulosus Diacylglycerol kinase theta 0.0109 0.0295 0.0293
Trypanosoma brucei DNA polymerase IV, putative 0.0187 0.0567 0.1356
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.058 0.1927 0.4627
Brugia malayi SET domain containing protein 0.0028 0.0017 0.0052
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0116
Giardia lamblia Heat shock protein HSP 90-alpha 0.0034 0.0036 0.0198
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0019 0.0112
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0174 0.0174
Mycobacterium ulcerans phosphoglycerate kinase 0.0514 0.1696 0.1759
Echinococcus granulosus ceramide kinase 0.0109 0.0295 0.0293
Schistosoma mansoni heat shock protein 0.0034 0.0036 0.0036
Schistosoma mansoni phd/f-box containing protein 0.0026 0.0009 0.0009
Schistosoma mansoni hypothetical protein 0.0321 0.1029 0.1029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0146 0.0425 0.0443
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0265 0.063
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Trypanosoma brucei DNA polymerase IV, putative 0.0201 0.0613 0.1469
Brugia malayi Phosphoglycerate kinase 0.0189 0.0571 0.2055
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0049 0.0089 0.0314
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0189 0.0571 0.1367
Onchocerca volvulus 0.0026 0.0007 0.0036
Echinococcus granulosus geminin 0.035 0.1129 0.1127
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0063 0.0061
Loa Loa (eye worm) ceramide kinase 0.0109 0.0295 0.0308
Echinococcus multilocularis importin subunit beta 1 0.003 0.0023 0.002
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0514 0.1696 0.4075
Brugia malayi Cell death protein 3 precursor 0.0026 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0109 0.0295 0.0295
Schistosoma mansoni DNA polymerase IV / kappa 0.0045 0.0076 0.0076
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0002 0.0002
Loa Loa (eye worm) beta-lactamase 0.0074 0.0174 0.0182
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0007 0.0043
Loa Loa (eye worm) hypothetical protein 0.0223 0.0691 0.072
Trichomonas vaginalis sphingosine kinase, putative 0.0109 0.0295 0.1058
Plasmodium falciparum heat shock protein 90 0.0034 0.0036 0.0198
Brugia malayi mucosa associated lymphoid tissue lymphoma translocation protein 1 0.0026 0.0007 0.0018
Echinococcus multilocularis caspase 2 0.0026 0.0007 0.0005
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0079 0.0277
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0146 0.0425 0.0425
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0321 0.1029 0.1073
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0035 0.004 0.0169
Loa Loa (eye worm) acetyltransferase 0.015 0.0439 0.0458
Trypanosoma cruzi metacaspase, putative 0.0026 0.0007 0.0018
Leishmania major hypothetical protein, conserved 0.0046 0.0078 0.0183
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.016 0.0471 0.1128
Trichomonas vaginalis set domain proteins, putative 0.0472 0.1551 0.5594
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0174 0.017
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.029 0.029
Trypanosoma brucei DNA damage repair protein, putative 0.0045 0.0076 0.0176
Brugia malayi PHD-finger family protein 0.0028 0.0016 0.005
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0095 0.0093
Trichomonas vaginalis conserved hypothetical protein 0.0109 0.0295 0.1058
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0199 0.0608 0.2188
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0016
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0176 0.0978
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0174 0.0621
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.004 0.0058 0.0058
Echinococcus granulosus endoplasmin 0.0027 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0144 0.0417 0.0435
Loa Loa (eye worm) hypothetical protein 0.0213 0.0657 0.0686
Onchocerca volvulus 0.0074 0.0174 0.1113
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0019 0.0112
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0188 0.0186
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0032 0.0077
Loa Loa (eye worm) hypothetical protein 0.0115 0.0316 0.033
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0107 0.029 0.0291
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0172 0.0515 0.1238
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0174 0.0172
Trypanosoma brucei diacylglycerol kinase, putative 0.0109 0.0295 0.0704
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0023 0.0049
Leishmania major diacylglycerol kinase-like protein 0.0109 0.0295 0.0704
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0174 0.017
Leishmania major hypothetical protein, conserved 0.0109 0.0295 0.0704
Loa Loa (eye worm) RecQ helicase 0.0112 0.0305 0.0319
Trichomonas vaginalis dullard protein, putative 0.0025 0.0005 0.001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0005 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0176 0.0184
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.029 0.104
Onchocerca volvulus 0.0037 0.0047 0.0294
Echinococcus multilocularis dnaJ subfamily B 0.2913 1 1
Trichomonas vaginalis sphingosine kinase, putative 0.0109 0.0295 0.1058
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0199 0.0608 0.1456
Echinococcus granulosus Diacylglycerol kinase zeta 0.0109 0.0295 0.0293
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0063 0.0066
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0188 0.0186
Schistosoma mansoni DNA helicase recq5 0.0046 0.0078 0.0078
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0514 0.1696 0.4075
Echinococcus granulosus histone acetyltransferase MYST2 0.0059 0.0122 0.012
Schistosoma mansoni importin beta-1 0.003 0.0023 0.0023
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0199 0.0608 0.1456
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0044 0.0069 0.0067
Schistosoma mansoni alkaline phosphatase 0.0164 0.0485 0.0485
Echinococcus granulosus neuropeptide s receptor 0.0939 0.3168 0.3167
Trypanosoma cruzi ISWI complex protein 0.0046 0.0078 0.0188
Schistosoma mansoni DNA helicase recq1 0.0046 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0028 0.0016 0.0017
Brugia malayi Bromodomain containing protein 0.0119 0.0331 0.1187
Loa Loa (eye worm) hypothetical protein 0.0074 0.0176 0.0184
Brugia malayi nuclear hormone receptor 0.0042 0.0063 0.0219
Mycobacterium leprae Probable lipase LipE 0.0074 0.0174 0.0966
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0164 0.0485 0.0483
Echinococcus granulosus lysine specific demethylase 6a 0.0026 0.0009 0.0007
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0097 0.0253 0.1479
Echinococcus granulosus caspase 2 0.0026 0.0007 0.0005
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0172 0.0515 0.1238
Trichomonas vaginalis DNA polymerase eta, putative 0.0201 0.0613 0.2207
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0116
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1226 0.4163 1
Trypanosoma cruzi Sphingosine kinase 0.0109 0.0295 0.0709
Echinococcus granulosus cpg binding protein 0.0254 0.0799 0.0797
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0026 0.0009 0.0021
Giardia lamblia Sgs1 DNA helicase, putative 0.0046 0.0078 0.0449
Trichomonas vaginalis ferritin, putative 0.0035 0.004 0.0136
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0108 0.0294 0.0292
Entamoeba histolytica recQ family helicase, putative 0.006 0.0125 0.0131
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0189 0.0571 0.1372
Trichomonas vaginalis rotamase, putative 0.0034 0.0035 0.0118
Schistosoma mansoni hypothetical protein 0.0085 0.0213 0.0213
Leishmania major hypothetical protein, conserved 0.0074 0.0174 0.0414
Schistosoma mansoni 6-phosphofructokinase 0.0107 0.029 0.029
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0079 0.0277
Schistosoma mansoni bromodomain containing protein 0.0028 0.0016 0.0016
Entamoeba histolytica acyl-CoA synthetase, putative 0.0074 0.0176 0.0184
Loa Loa (eye worm) MH2 domain-containing protein 0.0256 0.0803 0.0837
Loa Loa (eye worm) hypothetical protein 0.0116 0.0319 0.0333
Echinococcus granulosus neuropeptide receptor A26 0.0939 0.3168 0.3167
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Entamoeba histolytica hypothetical protein 0.0146 0.0424 0.0442
Brugia malayi exodeoxyribonuclease III family protein 0.0097 0.0253 0.0905
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0007 0.0018
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0075 0.0177 0.1044
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0007 0.0043
Schistosoma mansoni SET domain protein 0.0024 0.0002 0.0002
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0026 0.0009 0.0053
Leishmania major sphingosine kinase A, B, putative 0.0109 0.0295 0.0704
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0164 0.0485 0.0483
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0195 0.0595 0.0593
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0201 0.0613 0.2207
Schistosoma mansoni ferritin light chain 0.0035 0.004 0.004
Echinococcus multilocularis lysine specific demethylase 5A 0.0098 0.0257 0.0255
Echinococcus granulosus GPCR family 2 0.0207 0.0635 0.0633
Loa Loa (eye worm) hypothetical protein 0.0059 0.0122 0.0128
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0032 0.019
Treponema pallidum bacterioferrin (TpF1) 0.0035 0.004 0.0236
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0019 0.0099
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0044 0.0069 0.0067
Echinococcus multilocularis sphingosine kinase 1 0.2794 0.9587 0.9587
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.0002 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Mycobacterium ulcerans 6-phosphofructokinase 0.0107 0.029 0.0291
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0007 0.0018
Plasmodium falciparum diacylglycerol kinase, putative 0.0109 0.0295 0.1729
Trichomonas vaginalis heat shock protein, putative 0.0034 0.0036 0.0121
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0008
Schistosoma mansoni hypothetical protein 0.0207 0.0635 0.0635
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0063 0.0219
Loa Loa (eye worm) CXXC zinc finger family protein 0.0237 0.0738 0.077
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.0011 0.0054
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0195 0.0595 0.0593
Schistosoma mansoni ferritin 0.0035 0.004 0.004
Loa Loa (eye worm) hypothetical protein 0.0078 0.0188 0.0196
Treponema pallidum phosphoglycerate kinase 0.0514 0.1696 1
Schistosoma mansoni hypothetical protein 0.0146 0.0424 0.0424
Trypanosoma cruzi heat shock protein 90, putative 0.0027 0.0012 0.0029
Echinococcus granulosus dna polymerase eta 0.0223 0.0691 0.0689
Echinococcus multilocularis 0.0025 0.0005 0.0003
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0116
Brugia malayi Calcitonin receptor-like protein seb-1 0.0654 0.2182 0.7874
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0032 0.0077
Giardia lamblia Phosphoglycerate kinase 0.0514 0.1696 1
Mycobacterium ulcerans bacterioferritin BfrB 0.0035 0.004 0.0029
Trypanosoma cruzi metacaspase 5, putative 0.0026 0.0007 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0207 0.0635 0.0633
Loa Loa (eye worm) hypothetical protein 0.0074 0.0176 0.0184
Entamoeba histolytica diacylglycerol kinase, putative 0.0109 0.0295 0.0308
Echinococcus granulosus lysine specific demethylase 5A 0.0115 0.0318 0.0315
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0005 0.0016
Brugia malayi ImpB/MucB/SamB family protein 0.0146 0.0425 0.1525
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0005 0.0016
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0063 0.0138 0.0138
Brugia malayi steroid hormone receptor 0.0042 0.0063 0.0219
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0063 0.0066
Brugia malayi CXXC zinc finger family protein 0.0237 0.0738 0.2659
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0019 0.0112
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.0184
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0063 0.0061
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0063 0.0219
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0098 0.0098
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0027 0.0012 0.0023
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0059 0.0122 0.012
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0063 0.0063
Giardia lamblia DINP protein human, muc B family 0.016 0.0471 0.2769
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.029 0.104
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0046 0.0078 0.0274
Echinococcus multilocularis ferritin 0.0035 0.004 0.0038
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0174 0.0414
Echinococcus multilocularis caspase 3, apoptosis cysteine peptidase 0.0026 0.0007 0.0005
Echinococcus granulosus transcription factor Dp 1 0.0115 0.0318 0.0316
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0063 0.0061
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Trichomonas vaginalis hypothetical protein 0.0025 0.0005 0.0009
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0109 0.0295 0.0308
Echinococcus granulosus snurportin 1 0.0321 0.1029 0.1027
Echinococcus multilocularis caspase 8 0.0026 0.0007 0.0005
Echinococcus granulosus expressed protein 0.0035 0.004 0.0038
Echinococcus multilocularis phosphoglycerate kinase 1 0.0514 0.1696 0.1694
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0079 0.0277
Brugia malayi heat shock protein 90 0.0034 0.0036 0.0121
Trypanosoma cruzi DNA damage repair protein, putative 0.0045 0.0076 0.0182
Entamoeba histolytica diacylglycerol kinase, putative 0.0109 0.0295 0.0308
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0253 0.1479
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Schistosoma mansoni heat shock protein 0.0034 0.0036 0.0036
Trypanosoma cruzi heat shock protein 90, putative 0.0034 0.0036 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Loa Loa (eye worm) T-complex protein 1 0.0024 0.0002 0.0002
Echinococcus granulosus heat shock protein 90 0.0027 0.0012 0.001
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.1008
Entamoeba histolytica hypothetical protein 0.003 0.0022 0.0023
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0097 0.0253 0.0252
Trypanosoma cruzi Heat shock protein 83, putative 0.0034 0.0036 0.0086
Loa Loa (eye worm) hypothetical protein 0.0074 0.0174 0.0182
Echinococcus granulosus dna polymerase kappa 0.0201 0.0613 0.0611
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0174 0.017
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0016 0.0095
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.006 0.0125 0.0296
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0174 0.0182
Schistosoma mansoni transcription factor LCR-F1 0.0146 0.0424 0.0424
Brugia malayi diacylglycerol kinase 0.0109 0.0295 0.1058
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Trypanosoma brucei DNA polymerase eta, putative 0.0223 0.0691 0.1655
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0061
Plasmodium falciparum JmjC domain-containing protein, putative 0.0026 0.0009 0.0039
Leishmania major ATP-dependent phosphofructokinase 0.0107 0.029 0.0692
Plasmodium falciparum zinc finger protein, putative 0.003 0.0022 0.0117
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0027 0.0012 0.0003
Toxoplasma gondii hypothetical protein 0.0082 0.0202 0.1188
Trypanosoma cruzi Sphingosine kinase 0.0109 0.0295 0.0709
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.1552 0.1609
Loa Loa (eye worm) hypothetical protein 0.0052 0.0098 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Leishmania major phosphoglycerate kinase B, cytosolic 0.0514 0.1696 0.4072
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0063 0.0219
Mycobacterium ulcerans lipase LipD 0.0074 0.0174 0.017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0097 0.0253 0.0602
Echinococcus granulosus caspase 8 0.0026 0.0007 0.0005
Schistosoma mansoni cpg binding protein 0.0254 0.0799 0.0799
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0063 0.0219
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0052 0.0098 0.0618
Loa Loa (eye worm) hypothetical protein 0.01 0.0265 0.0276
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0052 0.0054
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0045 0.0076 0.0446
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0074 0.0176 0.0172
Echinococcus multilocularis heat shock protein 90 0.0027 0.0012 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0063 0.0219
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0019 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0176 0.0172
Plasmodium vivax DNA repair protein REV1, putative 0.0045 0.0076 0.0433
Schistosoma mansoni rotamase 0.0034 0.0035 0.0035
Schistosoma mansoni subfamily C14A unassigned peptidase (C14 family) 0.0026 0.0007 0.0007
Trypanosoma cruzi diacylglycerol kinase, putative 0.0109 0.0295 0.0709
Schistosoma mansoni endoplasmin 0.0034 0.0036 0.0036
Brugia malayi beta-lactamase family protein 0.0074 0.0174 0.0621
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0052 0.0295
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0049 0.0089 0.0525
Onchocerca volvulus 0.0042 0.0063 0.0394
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0063 0.0066
Mycobacterium ulcerans beta-lactamase 0.0074 0.0174 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0005 0.0009
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0156 0.0459 0.0456
Toxoplasma gondii heat shock protein 90, putative 0.0034 0.0036 0.0211
Toxoplasma gondii hypothetical protein 0.0198 0.0603 0.3556
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0063 0.0219
Schistosoma mansoni sphingoid long chain base kinase 0.2794 0.9587 0.9587
Echinococcus granulosus phosphoglycerate kinase 1 0.0514 0.1696 0.1694
Echinococcus multilocularis dna polymerase kappa 0.0201 0.0613 0.0611
Brugia malayi hypothetical protein 0.0128 0.0361 0.1294
Mycobacterium ulcerans bacterioferritin BfrA 0.0035 0.004 0.0029
Brugia malayi Diacylglycerol kinase protein 2 0.0109 0.0295 0.1058
Brugia malayi jmjC domain containing protein 0.0156 0.0459 0.1648
Schistosoma mansoni phosphoglycerate kinase 0.0514 0.1696 0.1696
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0003 0.0002
Trypanosoma brucei phosphoglycerate kinase 0.0514 0.1696 0.4072
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.0035 0.0118
Loa Loa (eye worm) transcription factor SMAD2 0.0256 0.0803 0.0837
Plasmodium falciparum phosphoglycerate kinase 0.0514 0.1696 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0003 0.0007
Trichomonas vaginalis helicase, putative 0.0046 0.0079 0.0277
Echinococcus multilocularis 6 phosphofructokinase 0.0107 0.029 0.0288
Loa Loa (eye worm) hypothetical protein 0.0046 0.0078 0.0082
Brugia malayi ImpB/MucB/SamB family protein 0.0223 0.0691 0.2486
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Echinococcus granulosus heat shock protein 90 0.0034 0.0036 0.0034
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0654 0.2182 0.7874
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0176 0.0628
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0188 0.1049
Loa Loa (eye worm) hypothetical protein 0.0074 0.0176 0.0184
Giardia lamblia Grp94/Hsp90 0.0027 0.0012 0.0057
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.029 0.0303
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0012 0.0035
Onchocerca volvulus 0.0074 0.0174 0.1113
Trypanosoma brucei metacaspase 0.0026 0.0007 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0063 0.0066
Loa Loa (eye worm) histone methyltransferase 0.0065 0.0145 0.0151
Loa Loa (eye worm) diacylglycerol kinase 2 0.0109 0.0295 0.0308
Leishmania major DNA damage repair protein, putative 0.0045 0.0076 0.0176
Brugia malayi Eye-specific diacylglycerol kinase 0.0109 0.0295 0.1058
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0318 0.0318
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0076 0.0176
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0308
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Echinococcus multilocularis expressed protein 0.0035 0.004 0.0038
Trypanosoma cruzi ISWI complex protein 0.0046 0.0078 0.0188
Loa Loa (eye worm) endoplasmin 0.0034 0.0036 0.0037
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trypanosoma brucei phosphoglycerate kinase 0.0189 0.0571 0.1367
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0076 0.0182
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0033 0.0032 0.0034
Loa Loa (eye worm) hypothetical protein 0.0065 0.0145 0.0151
Brugia malayi Pre-SET motif family protein 0.0415 0.1355 0.4885
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0019 0.0061
Mycobacterium ulcerans acyl-CoA synthetase 0.0074 0.0176 0.0172
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0063 0.0061
Treponema pallidum exodeoxyribonuclease (exoA) 0.0097 0.0253 0.149
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0316 0.0316
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0016 0.0017
Schistosoma mansoni protein phosphatase 2C 0.0026 0.0009 0.0009
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0019 0.0112
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0063 0.0063
Echinococcus multilocularis microtubule associated protein 2 0.1436 0.4889 0.4888
Schistosoma mansoni ap endonuclease 0.0097 0.0253 0.0253
Plasmodium vivax metacaspase 1, putative 0.0026 0.0007 0.003
Echinococcus granulosus ferritin 0.0035 0.004 0.0038
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0063 0.0063
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0207 0.0635 0.0633
Schistosoma mansoni ferritin 0.0035 0.004 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0114 0.0314 0.075
Plasmodium vivax importin-beta 2, putative 0.003 0.0023 0.012
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.021 0.0646 0.1552
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0174 0.0966
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0005 0.001
Trichomonas vaginalis bromodomain-containing protein, putative 0.0049 0.0089 0.0314
Trypanosoma brucei unspecified product 0.0101 0.0268 0.0638
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.015 0.0439 0.0437
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0109 0.0295 0.0709
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0101 0.0093
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0063 0.0138 0.0136
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0101 0.0093
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0654 0.2182 0.2276
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0063 0.0063
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0019 0.0099
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0097 0.0253 0.0607
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.0011 0.0054
Onchocerca volvulus 0.0237 0.0738 0.4755
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.1008
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0146 0.0424 0.0422
Toxoplasma gondii hypothetical protein 0.0027 0.0011 0.0068
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0074 0.0176 0.0978
Loa Loa (eye worm) bromodomain containing protein 0.0057 0.0115 0.012
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0134 0.0134
Brugia malayi F/Y-rich N-terminus family protein 0.008 0.0194 0.0693
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0097 0.0097
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Echinococcus granulosus caspase 3 apoptosis cysteine peptidase 0.0026 0.0007 0.0005
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0097 0.0253 0.0607
Brugia malayi polk-prov protein 0.01 0.0265 0.0947
Echinococcus multilocularis SAM and MBT domain containing protein 0.0052 0.0098 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Echinococcus granulosus histone lysine methyltransferase setb 0.0115 0.0316 0.0314
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0097 0.0253 0.0905
Toxoplasma gondii ICE family protease (caspase) p20 domain-containing protein 0.0026 0.0007 0.0043
Brugia malayi nuclear receptor NHR-88 0.0042 0.0063 0.0219
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0172 0.0515 0.1238
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0036 0.0086
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0063 0.0063
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0174 0.0174
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.015 0.0439 0.0439
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.029 0.0303
Echinococcus multilocularis lysine specific demethylase 6a 0.0026 0.0009 0.0007
Echinococcus multilocularis Diacylglycerol kinase theta 0.0109 0.0295 0.0293
Plasmodium falciparum acyl-CoA synthetase 0.0056 0.0111 0.0642
Echinococcus multilocularis endoplasmin 0.0027 0.0012 0.001
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0174 0.0182
Trypanosoma brucei hypothetical protein, conserved 0.0109 0.0295 0.0704
Giardia lamblia PHD finger protein 15 0.0028 0.0016 0.0082
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0016 0.0016
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0002 0.0002
Onchocerca volvulus Huntingtin homolog 0.0128 0.0361 0.2315
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0207 0.0635 0.2285
Echinococcus granulosus histone acetyltransferase KAT2B 0.0049 0.0089 0.0087
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0026 0.0009 0.0016
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0079 0.0277
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0046 0.0078 0.0082
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0842 0.2834 0.2832
Echinococcus granulosus alkaline phosphatase 0.0164 0.0485 0.0483
Plasmodium falciparum phd finger protein, putative 0.0028 0.0016 0.0082
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0164 0.0485 0.0483
Trypanosoma brucei metacaspase MCA2 0.0026 0.0007 0.0012
Trichomonas vaginalis esterase, putative 0.0074 0.0174 0.0621
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Brugia malayi mbt repeat family protein 0.0052 0.0098 0.0344
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0109 0.0295 0.1058
Schistosoma mansoni zinc finger protein 0.0046 0.0078 0.0078
Mycobacterium ulcerans diacylglycerol kinase 0.0109 0.0295 0.0296
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0005 0.0009
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0016 0.0014
Trypanosoma brucei DNA polymerase kappa, putative 0.0114 0.0314 0.075
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0036 0.0037
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0189 0.0571 0.1372
Echinococcus multilocularis expressed protein 0.0034 0.0035 0.0033
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0063 0.0063
Giardia lamblia DNA damage repair protein 0.0045 0.0076 0.0433
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0016 0.0014
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.006 0.0125 0.0296
Loa Loa (eye worm) hypothetical protein 0.0074 0.0174 0.0182
Toxoplasma gondii exonuclease III APE 0.0097 0.0253 0.149
Trypanosoma brucei mitochondrial DNA polymerase beta 0.1226 0.4163 1
Echinococcus multilocularis polycomb protein SCMH1 0.0052 0.0098 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0063 0.0219
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0005 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.058 0.1927 0.4627
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0063 0.0219
Loa Loa (eye worm) hypothetical protein 0.0026 0.0009 0.0009
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0174 0.0621
Brugia malayi mbt repeat family protein 0.0052 0.0098 0.0344
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0063 0.0219
Trypanosoma brucei DNA polymerase kappa, putative 0.0114 0.0314 0.075
Brugia malayi Ceramide kinase 0.0109 0.0295 0.1058
Entamoeba histolytica deoxycytidyl transferase, putative 0.0146 0.0425 0.0443
Schistosoma mansoni hypothetical protein 0.2913 1 1
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.0002 0.0013
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0063 0.0066
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0207 0.0635 0.0633
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0063 0.0063
Schistosoma mansoni blooms syndrome DNA helicase 0.0088 0.0224 0.0224
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Brugia malayi hypothetical protein 0.0109 0.0295 0.1058
Trypanosoma brucei metacaspase 5, putative 0.0026 0.0007 0.0012
Brugia malayi Pre-SET motif family protein 0.0063 0.0138 0.049
Trypanosoma cruzi heat shock protein 85, putative 0.0027 0.0012 0.0029
Mycobacterium ulcerans hypothetical protein 0.0074 0.0176 0.0172
Trypanosoma brucei chrX additional, unordered contigs 0.0045 0.0076 0.0176
Entamoeba histolytica acyl-coA synthetase, putative 0.0074 0.0176 0.0184
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0005 0.0003
Plasmodium vivax diacylglycerol kinase, putative 0.0109 0.0295 0.1729
Schistosoma mansoni sphingosine kinase A B 0.2794 0.9587 0.9587
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0054 0.0052
Onchocerca volvulus Cell death protein 3 homolog 0.0026 0.0007 0.0035
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.0613 0.1474
Schistosoma mansoni zinc finger protein 0.0074 0.0176 0.0176
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0065 0.0145 0.0143
Loa Loa (eye worm) phosphofructokinase 0.0107 0.029 0.0303
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0051 0.0097 0.0094
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.04 0.0398
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0199 0.0608 0.0606
Echinococcus multilocularis bloom syndrome protein 0.0112 0.0305 0.0303
Leishmania major DNA polymerase kappa, putative 0.0045 0.0076 0.0176
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0109 0.0295 0.0704
Mycobacterium tuberculosis Conserved protein 0.0074 0.0174 0.017
Trypanosoma cruzi hypothetical protein, conserved 0.0045 0.0076 0.0182
Brugia malayi Probable ClpP-like protease 0.0078 0.0188 0.0671
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0009 0.0009
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0199 0.0608 0.0634
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0146 0.0424 0.0422
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0005 0.001
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0023 0.0049
Mycobacterium ulcerans DNA polymerase IV 0.0201 0.0613 0.0628
Schistosoma mansoni sex comb on midleg homolog 0.0052 0.0098 0.0098
Brugia malayi Phosphoglycerate kinase 0.0514 0.1696 0.6119
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0009 0.0009
Trichomonas vaginalis bmru protein, putative 0.0109 0.0295 0.1058
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0174 0.017
Loa Loa (eye worm) hypothetical protein 0.0025 0.0004 0.0004
Trypanosoma cruzi metacaspase, putative 0.0026 0.0007 0.0018
Mycobacterium tuberculosis Conserved protein 0.2794 0.9587 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0051 0.0097 0.0094
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0164 0.0485 0.0483
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0003 0.0002
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0003 0.0002
Echinococcus multilocularis ceramide kinase 0.0109 0.0295 0.0293
Brugia malayi Importin beta-1 subunit 0.003 0.0023 0.0074
Echinococcus multilocularis GPCR, family 2 0.0207 0.0635 0.0633
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.0613 0.1474
Brugia malayi glutaminase DH11.1 0.0824 0.2771 1
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0174 0.0621
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0056 0.0111 0.0549
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0042 0.0063 0.0066
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0007 0.003
Echinococcus multilocularis jumonji domain containing 1A 0.0026 0.0009 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0063 0.0219
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0016 0.0082
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0063 0.0061
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0063 0.0138 0.0813
Mycobacterium tuberculosis Conserved protein 0.0074 0.0174 0.017
Entamoeba histolytica heat shock protein 90, putative 0.0034 0.0036 0.0037
Echinococcus granulosus jumonji domain containing 1A 0.0026 0.0009 0.0007
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0097 0.0253 0.0251
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0095 0.0093
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0174 0.0419
Entamoeba histolytica phosphofructokinase, putative 0.0107 0.029 0.0303
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0097 0.0253 0.0252
Echinococcus granulosus sphingosine kinase 1 0.2794 0.9587 0.9587
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0074 0.0176 0.0172
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0031 0.0028 0.0028
Schistosoma mansoni diacylglycerol kinase theta 0.0109 0.0295 0.0295
Trypanosoma brucei unspecified product 0.0187 0.0567 0.1356
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0063 0.0063
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0059 0.0122 0.012
Loa Loa (eye worm) hypothetical protein 0.0074 0.0174 0.0182
Trypanosoma cruzi diacylglycerol kinase, putative 0.0109 0.0295 0.0709
Trypanosoma brucei heat shock protein 90, putative 0.0034 0.0036 0.0081
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Trypanosoma brucei heat shock protein, putative 0.0034 0.0036 0.0081
Echinococcus multilocularis JmjC domain containing protein 4 0.0026 0.0009 0.0007
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0174 0.0621
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0079 0.0277
Onchocerca volvulus Huntingtin homolog 0.0128 0.0361 0.2315
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0107 0.029 0.1711
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0063 0.0061
Schistosoma mansoni hypothetical protein 0.0062 0.0134 0.0134
Echinococcus multilocularis heat shock protein 90 0.0034 0.0036 0.0034
Leishmania major DNA polymerase eta, putative 0.0122 0.0342 0.0816
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0063 0.0066
Brugia malayi hypothetical protein 0.0146 0.0424 0.1523
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0063 0.0061
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0097 0.0253 0.0251
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0188 0.0188
Echinococcus granulosus caspase 0.0026 0.0007 0.0005
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0109 0.0295 0.0709
Trypanosoma brucei DNA damage repair protein, putative 0.0045 0.0076 0.0176
Plasmodium vivax SET domain protein, putative 0.0063 0.0138 0.08
Echinococcus granulosus peregrin 0.0039 0.0053 0.0051
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0074 0.0176 0.0172
Loa Loa (eye worm) 6-phosphofructokinase 0.0107 0.029 0.0303
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.008 0.0194 0.0194
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0005 0.0005
Trypanosoma brucei phosphoglycerate kinase 0.0514 0.1696 0.4072
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0046 0.0078 0.0076
Schistosoma mansoni microtubule-associated protein tau 0.1436 0.4889 0.4889
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Plasmodium falciparum metacaspase 1 0.0026 0.0007 0.003
Brugia malayi jmjC domain containing protein 0.0026 0.0009 0.0024
Echinococcus multilocularis dna polymerase eta 0.0223 0.0691 0.0689
Onchocerca volvulus 0.0074 0.0174 0.1113
Echinococcus multilocularis heat shock protein 0.0034 0.0036 0.0034
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0063 0.0061
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0035 0.004 0.0029
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0176 0.0418
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.0002 0.0002
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0032 0.0072
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0109 0.0295 0.0293
Schistosoma mansoni phosphoglycerate kinase 0.0514 0.1696 0.1696
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0074 0.0176 0.0172
Loa Loa (eye worm) PHD-finger family protein 0.0062 0.0134 0.014
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0007 0.0018
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.029 0.104
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0005 0.001
Brugia malayi Bloom's syndrome protein homolog 0.0112 0.0305 0.1095
Echinococcus granulosus phd:f box containing protein 0.0026 0.0009 0.0007
Leishmania major hypothetical protein, conserved 0.0025 0.0005 0.0007
Schistosoma mansoni phosphatidylserine receptor 0.0026 0.0009 0.0009
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Trypanosoma brucei DNA polymerase kappa, putative 0.01 0.0265 0.063
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0223 0.0691 0.0689
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0101 0.0093
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0063 0.0394
Schistosoma mansoni hypothetical protein 0.035 0.1129 0.1129
Toxoplasma gondii ABC1 family protein 0.0074 0.0174 0.1028
Trypanosoma brucei Heat shock protein 83, putative 0.0034 0.0036 0.0081
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0174 0.0172
Chlamydia trachomatis phosphoglycerate kinase 0.0514 0.1696 1
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0005 0.0012
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0063 0.0063
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Echinococcus multilocularis peregrin 0.0039 0.0053 0.0051
Schistosoma mansoni hypothetical protein 0.0028 0.0016 0.0016
Brugia malayi 6-phosphofructokinase 0.0107 0.029 0.104
Loa Loa (eye worm) hypothetical protein 0.003 0.0023 0.0024
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0046 0.0079 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0063 0.0219
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.058 0.1927 0.463
Schistosoma mansoni methyl-cpg binding protein mbd 0.0051 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0514 0.1696 0.1769
Trichomonas vaginalis dullard protein, putative 0.0025 0.0005 0.001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0079 0.0277
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0109 0.0295 0.0293
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0109 0.0295 0.174
Schistosoma mansoni coup transcription factor 0.0042 0.0063 0.0063
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0156 0.0459 0.0456
Echinococcus multilocularis caspase 0.0026 0.0007 0.0005
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0026 0.0009 0.0009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0063 0.0066
Leishmania major hypothetical protein, conserved 0.0026 0.0009 0.0016
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0056 0.0111 0.0104
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0009 0.0009
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0063 0.0061
Loa Loa (eye worm) hypothetical protein 0.0074 0.0174 0.0182
Schistosoma mansoni glutaminase 0.0824 0.2771 0.2771
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0174 0.1016
Brugia malayi PHD-finger family protein 0.0027 0.0011 0.0031
Echinococcus multilocularis histone acetyltransferase MYST2 0.0059 0.0122 0.012
Echinococcus granulosus microtubule associated protein 2 0.1436 0.4889 0.4888
Plasmodium vivax diacylglycerol kinase, putative 0.0109 0.0295 0.1729
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0174 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0074 0.0176 0.0172
Leishmania major diacylglycerol kinase, putative 0.0109 0.0295 0.0704
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0007 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0056 0.0111 0.0104
Brugia malayi AMP-binding enzyme family protein 0.0074 0.0176 0.0628
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.0184
Loa Loa (eye worm) hypothetical protein 0.0126 0.0356 0.0372
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0098 0.0258 0.1512
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0097 0.0253 0.1479
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0035 0.004 0.0166
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0036 0.0086
Trypanosoma brucei unspecified product 0.0101 0.0268 0.0638
Brugia malayi RNA, U transporter 1 0.0085 0.0214 0.0766
Loa Loa (eye worm) heat shock protein 90 0.0034 0.0036 0.0037
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0514 0.1696 0.6119
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0032 0.0072
Echinococcus granulosus fetal alzheimer antigen falz 0.008 0.0194 0.0192
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0223 0.0691 0.0689
Brugia malayi Latrophilin receptor protein 2 0.0207 0.0635 0.2285
Loa Loa (eye worm) jmjC domain-containing protein 0.0115 0.0318 0.0331
Trypanosoma brucei DNA polymerase kappa, putative 0.0201 0.0613 0.1469
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0034 0.0035 0.0118
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0053 0.0102 0.01
Loa Loa (eye worm) jmjC domain-containing protein 0.0026 0.0009 0.0009
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0049 0.0089 0.0525
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0095 0.0087
Leishmania major phosphoglycerate kinase C, glycosomal 0.0514 0.1696 0.4072
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0164 0.0485 0.0483
Schistosoma mansoni jumonji/arid domain-containing protein 0.0115 0.0318 0.0318
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0005 0.001
Brugia malayi 6-phosphofructokinase 0.0107 0.029 0.104
Plasmodium falciparum importin beta, putative 0.003 0.0023 0.012
Trichomonas vaginalis DNA helicase recq, putative 0.0112 0.0305 0.1095
Plasmodium falciparum diacylglycerol kinase, putative 0.0109 0.0295 0.1729
Entamoeba histolytica hypothetical protein 0.0146 0.0424 0.0442
Leishmania major mitochondrial DNA polymerase beta 0.1226 0.4163 1
Trypanosoma cruzi metacaspase, putative 0.0026 0.0007 0.0018
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0063 0.0061
Brugia malayi MH2 domain containing protein 0.0256 0.0803 0.2892
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0007 0.0007
Schistosoma mansoni DNA polymerase eta 0.0223 0.0691 0.0691
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0176 0.0418
Toxoplasma gondii diacylglycerol kinase, putative 0.0109 0.0295 0.174
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0052 0.0295
Echinococcus granulosus intestinal type alkaline phosphatase 0.0164 0.0485 0.0483
Onchocerca volvulus 0.0074 0.0176 0.1125
Plasmodium falciparum metacaspase-like protein 0.0026 0.0007 0.003
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0188 0.1109
Plasmodium vivax heat shock protein 86, putative 0.0034 0.0036 0.0198
Brugia malayi diacylglycerol kinase 0.0109 0.0295 0.1058
Leishmania major metacaspase, putative 0.0026 0.0007 0.0012
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0012 0.0035
Schistosoma mansoni diacylglycerol kinase theta 0.0109 0.0295 0.0295
Echinococcus multilocularis alkaline phosphatase 0.0164 0.0485 0.0483
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0027 0.0012 0.001
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0514 0.1696 0.1759
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0019 0.0099
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0019 0.0099
Echinococcus multilocularis snurportin 1 0.0321 0.1029 0.1027
Entamoeba histolytica hypothetical protein, conserved 0.2794 0.9587 1
Echinococcus granulosus importin subunit beta 1 0.003 0.0023 0.002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0046 0.0079 0.0277
Brugia malayi PHD-finger family protein 0.009 0.0231 0.0827
Schistosoma mansoni hypothetical protein 0.0025 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0079 0.0277
Schistosoma mansoni hypothetical protein 0.035 0.1129 0.1129
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0074 0.0176 0.0418
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0115 0.0316 0.0314
Echinococcus granulosus SAM and MBT domain containing protein 0.0052 0.0098 0.0095
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0514 0.1696 0.6119
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0053 0.0102 0.01
Echinococcus granulosus 6 phosphofructokinase 0.0107 0.029 0.0288
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0188 0.1097
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0063 0.0219
Loa Loa (eye worm) hypothetical protein 0.0447 0.1466 0.1529
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.006 0.0125 0.0301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0063 0.0061
Mycobacterium tuberculosis Conserved protein 0.0074 0.0174 0.017
Trichomonas vaginalis DNA helicase recq1, putative 0.0112 0.0305 0.1095
Onchocerca volvulus 0.0109 0.0295 0.1893
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0109 0.0295 0.1058
Trypanosoma cruzi DNA polymerase kappa, putative 0.0201 0.0613 0.1474
Loa Loa (eye worm) hypothetical protein 0.0128 0.0361 0.0376
Plasmodium vivax JmjC domain containing protein 0.0026 0.0009 0.0039
Schistosoma mansoni caspase-7 (C14 family) 0.0026 0.0007 0.0007
Echinococcus granulosus disco interacting protein 2 0.004 0.0058 0.0056
Trypanosoma brucei phosphoglycerate kinase, putative 0.0189 0.0571 0.1367
Trichomonas vaginalis heat shock protein, putative 0.0027 0.0012 0.0035
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0097 0.0253 0.143
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0109 0.0295 0.0709
Echinococcus granulosus JmjC domain containing protein 4 0.0026 0.0009 0.0007
Trichomonas vaginalis diacylglycerol kinase, putative 0.0109 0.0295 0.1058
Echinococcus multilocularis geminin 0.035 0.1129 0.1127
Schistosoma mansoni ferritin 0.0035 0.004 0.004
Trypanosoma brucei Sphingosine kinase 0.0109 0.0295 0.0704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0063 0.0219
Brugia malayi phosphofructokinase 0.0107 0.029 0.104
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0188 0.1109
Schistosoma mansoni hypothetical protein 0.0207 0.0635 0.0635
Loa Loa (eye worm) hypothetical protein 0.0109 0.0295 0.0308
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0059 0.0123 0.0722
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0436 0.1428 0.1428
Trypanosoma cruzi DNA polymerase eta, putative 0.0223 0.0691 0.1659
Plasmodium falciparum DNA repair protein REV1, putative 0.0045 0.0076 0.0433
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0122 0.0342 0.2015
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0109 0.0295 0.1058
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0174 0.017
Trichomonas vaginalis rotamase, putative 0.0033 0.0032 0.0108
Echinococcus multilocularis phd:f box containing protein 0.0026 0.0009 0.0007
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0026 0.0009 0.0053
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0005 0.003
Echinococcus multilocularis neuropeptide receptor A26 0.0939 0.3168 0.3167
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0199 0.0608 0.0606
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0082 0.0202 0.1176
Entamoeba histolytica hypothetical protein 0.0146 0.0424 0.0442
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0005 0.0005
Leishmania major heat shock protein 83-1 0.0034 0.0036 0.0081
Loa Loa (eye worm) glutaminase 2 0.0824 0.2771 0.289
Entamoeba histolytica phosphoglycerate kinase, putative 0.0514 0.1696 0.1769
Leishmania major DNA polymerase eta, putative 0.0223 0.0691 0.1655
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0005 0.0003
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0007 0.0018
Trichomonas vaginalis Clan CD, family C14, metacaspase-like cysteine peptidase 0.0026 0.0007 0.0018
Toxoplasma gondii histone lysine methyltransferase SET1 0.04 0.1304 0.7687
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0063 0.0219
Schistosoma mansoni apoferritin-2 0.0035 0.004 0.004
Schistosoma mansoni hypothetical protein 0.0207 0.0635 0.0635
Schistosoma mansoni ferritin 0.0035 0.004 0.004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0172 0.0515 0.1233
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0063 0.0063
Trichomonas vaginalis phosphofructokinase, putative 0.0107 0.029 0.104
Loa Loa (eye worm) hypothetical protein 0.0056 0.0111 0.0116
Entamoeba histolytica hypothetical protein 0.0024 0.0003 0.0003
Treponema pallidum heat shock protein 90 0.0027 0.0012 0.0071
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0189 0.0571 0.1372
Trypanosoma cruzi heat shock protein 85, putative 0.0034 0.0036 0.0086
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.1226 0.4163 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0059 0.0122 0.0434
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0097 0.0253 0.0602
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0035 0.004 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0115 0.0316 0.0316
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0063 0.0061
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0199 0.0608 0.0608
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0063 0.0138 0.0138
Mycobacterium ulcerans DNA polymerase IV 0.0201 0.0613 0.0628
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0174 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0053 0.0101 0.0093

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 2 % Growth inhibition of human HCT116 cells assessed as dead cells at 10 uM after 48 hrs by sulforhodamine-B assay relative to control ChEMBL. 23811086

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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