Detailed information for compound 1783250

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 281.349 | Formula: C18H19NO2
  • H donors: 1 H acceptors: 1 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)cc(cc2)OCCCc1ccccc1
  • InChi: 1S/C18H19NO2/c20-18-11-9-15-8-10-16(13-17(15)19-18)21-12-4-7-14-5-2-1-3-6-14/h1-3,5-6,8,10,13H,4,7,9,11-12H2,(H,19,20)
  • InChiKey: FCNRKSJOVWUYPU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens monoamine oxidase B Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH Get druggable targets OG5_130722 All targets in OG5_130722
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi amine oxidase, flavin-containing family protein monoamine oxidase B 520 aa 462 aa 19.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0008 0.0008
Brugia malayi diacylglycerol kinase 0.0102 0.0319 0.1433
Trypanosoma brucei unspecified product 0.0073 0.0207 0.0586
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0037 0.0239
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0052 0.0154
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0161 0.0544 0.0544
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0057 0.0057
Brugia malayi hypothetical protein 0.0102 0.0319 0.1433
Entamoeba histolytica hypothetical protein 0.011 0.0349 0.0341
Schistosoma mansoni sphingoid long chain base kinase 0.2616 1 1
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Entamoeba histolytica deoxycytidyl transferase, putative 0.0106 0.0333 0.0325
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0045 0.0098 0.0742
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0202
Echinococcus granulosus heat shock protein 90 0.0032 0.0051 0.0051
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0021 0.0008 0.0002
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0427 0.1571 0.4606
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Echinococcus multilocularis neuropeptide receptor A26 0.0919 0.3467 0.3467
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.1614
Onchocerca volvulus 0.0072 0.0202 0.2399
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0134
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0083 0.0083
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0028 0.0015
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0038 0.0122
Schistosoma mansoni rotamase 0.0033 0.0053 0.0053
Brugia malayi acetyltransferase, GNAT family protein 0.0148 0.0497 0.2237
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0106 0.0333 0.0325
Onchocerca volvulus 0.0025 0.0024 0.0275
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0008
Loa Loa (eye worm) ceramide kinase 0.0102 0.0319 0.0318
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0083 0.0083
Trypanosoma brucei hypothetical protein, conserved 0.0102 0.0319 0.0916
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0023
Mycobacterium ulcerans beta-lactamase 0.0072 0.0202 0.0194
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0008 0.0007
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0127 0.0415 0.1199
Toxoplasma gondii hypothetical protein 0.0026 0.0028 0.0161
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0124 0.0405 0.119
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0825 0.3102 0.3102
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0083 0.0083
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0083 0.0083
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0001
Brugia malayi nuclear hormone receptor 0.0041 0.0083 0.0374
Brugia malayi Bromodomain containing protein 0.0163 0.0552 0.2485
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0108 0.0341 0.2616
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0028 0.0021
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0024 0.0168
Brugia malayi Diacylglycerol kinase protein 2 0.0102 0.0319 0.1433
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0023
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0119 0.0119
Loa Loa (eye worm) beta-lactamase 0.0072 0.0202 0.0202
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0102 0.0319 0.0318
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.002 0.0086
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.0219 0.0219
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0009
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.022 0.1735
Echinococcus granulosus bloom syndrome protein 0.0066 0.0181 0.0181
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0176
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0134
Plasmodium vivax DNA repair protein REV1, putative 0.0033 0.0052 0.0365
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0026 0.0053
Echinococcus multilocularis expressed protein 0.0033 0.0053 0.0053
Loa Loa (eye worm) hypothetical protein 0.0021 0.0008 0.0008
Entamoeba histolytica hypothetical protein 0.0023 0.0016 0.0008
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0024 0.002 0.0083
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0077 0.037
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0072 0.0205 0.0197
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.0115
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0596 0.2221 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0026 0.0026
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0161 0.0544 0.0544
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0102 0.0319 0.0318
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0131 0.0432 0.0432
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0083 0.0083
Mycobacterium ulcerans hypothetical protein 0.2616 1 1
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0024 0.002 0.0019
Trichomonas vaginalis esterase, putative 0.0072 0.0202 0.0989
Entamoeba histolytica diacylglycerol kinase, putative 0.0102 0.0319 0.0311
Brugia malayi hypothetical protein 0.0022 0.0009 0.004
Echinococcus granulosus mixed lineage leukemia protein mll 0.0044 0.0096 0.0096
Chlamydia trachomatis phosphoglycerate kinase 0.0339 0.123 1
Mycobacterium ulcerans DNA polymerase IV 0.0158 0.0537 0.0529
Trichomonas vaginalis hypothetical protein 0.0021 0.0007 0.0022
Schistosoma mansoni ferritin light chain 0.0026 0.0028 0.0028
Schistosoma mansoni hypothetical protein 0.011 0.0349 0.0348
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0034 0.0057 0.0057
Echinococcus granulosus dna polymerase eta 0.0156 0.0528 0.0528
Leishmania major hypothetical protein, conserved 0.0072 0.0202 0.0573
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.004
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.0202 0.0201
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0083 0.0374
Trichomonas vaginalis sphingosine kinase, putative 0.0102 0.0319 0.1568
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0083 0.0083
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0108 0.0341 0.2723
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0155 0.0522 0.1534
Plasmodium vivax diacylglycerol kinase, putative 0.0102 0.0319 0.2543
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0076 0.022 0.1739
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0055 0.0137 0.0137
Trypanosoma brucei ISWI complex protein 0.003 0.0043 0.0105
Onchocerca volvulus 0.0072 0.0202 0.2399
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Leishmania major T-complex protein 1, beta subunit, putative 0.0024 0.002 0.0034
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Schistosoma mansoni sphingosine kinase A B 0.2616 1 1
Loa Loa (eye worm) hypothetical protein 0.0102 0.0319 0.0318
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0072 0.0205 0.0197
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0083 0.0083
Mycobacterium ulcerans hypothetical protein 0.0072 0.0202 0.0194
Brugia malayi hypothetical protein 0.0025 0.0024 0.0104
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0055 0.0137 0.0136
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0009
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0026 0.0145
Onchocerca volvulus 0.0025 0.0023 0.0266
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0341 0.034
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0009
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.022 0.1737
Echinococcus granulosus methyl CpG binding domain protein 2 0.0034 0.0057 0.0057
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0205 0.0197
Toxoplasma gondii histone lysine methyltransferase SET1 0.0337 0.1225 0.996
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0075 0.059
Echinococcus multilocularis ferritin 0.0026 0.0028 0.0028
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0055 0.0137 0.0137
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0083 0.0083
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0027 0.0031 0.0232
Trypanosoma brucei unspecified product 0.0145 0.0486 0.1409
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0009 0.0009
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0051 0.0151
Echinococcus granulosus heat shock protein 0.0032 0.0051 0.0051
Onchocerca volvulus 0.0041 0.0083 0.0987
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0037 0.0086
Leishmania major diacylglycerol kinase, putative 0.0102 0.0319 0.0916
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0083 0.0083
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0341 0.1678
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0102 0.0319 0.0937
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0083 0.0083
Loa Loa (eye worm) diacylglycerol kinase 2 0.0102 0.0319 0.0318
Loa Loa (eye worm) histone methyltransferase 0.0055 0.0137 0.0136
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Echinococcus multilocularis bloom syndrome protein 0.0066 0.0181 0.0181
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0008 0.0008
Mycobacterium ulcerans oxidoreductase 0.0025 0.0024 0.0015
Schistosoma mansoni ap endonuclease 0.0076 0.022 0.022
Schistosoma mansoni amine oxidase 0.0025 0.0024 0.0023
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0202 0.0989
Echinococcus granulosus beta LACTamase domain containing family member 0.0072 0.0202 0.0202
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0202 0.0202
Trichomonas vaginalis glutaminase, putative 0.0543 0.2016 1
Trypanosoma cruzi ISWI complex protein 0.003 0.0043 0.0128
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0038 0.0249
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0083 0.0083
Schistosoma mansoni cpg binding protein 0.0187 0.0646 0.0645
Leishmania major DNA polymerase eta, putative 0.0083 0.0248 0.0707
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0083 0.0083
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0339 0.123 0.6096
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0215 0.0753 0.0753
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0031 0.014
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0339 0.123 1
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.1307 0.13
Brugia malayi Phosphoglycerate kinase 0.0124 0.0405 0.1821
Entamoeba histolytica diacylglycerol kinase, putative 0.0102 0.0319 0.0311
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0341 0.1678
Trichomonas vaginalis heat shock protein, putative 0.0032 0.0051 0.024
Trichomonas vaginalis DNA helicase recq, putative 0.0066 0.0181 0.0885
Onchocerca volvulus Huntingtin homolog 0.0122 0.0397 0.4719
Onchocerca volvulus 0.0033 0.0054 0.0641
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0043 0.0043
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.0432 0.127
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.001
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0076 0.022 0.0626
Leishmania major ATP-dependent phosphofructokinase 0.0108 0.0341 0.0981
Brugia malayi heat shock protein 90 0.0032 0.0051 0.0229
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0083 0.0083
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0044 0.0096 0.0096
Treponema pallidum exodeoxyribonuclease (exoA) 0.0076 0.022 0.1616
Toxoplasma gondii exonuclease III APE 0.0076 0.022 0.1739
Giardia lamblia TCP-1 chaperonin subunit beta 0.0024 0.002 0.0096
Echinococcus multilocularis 0.0025 0.0024 0.0023
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.002 0.0019
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0083 0.0374
Mycobacterium tuberculosis Probable lipase LipE 0.0072 0.0202 0.0194
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0134 0.1036
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0051 0.0121 0.0121
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0025 0.0024 0.0023
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0185 0.0185
Leishmania major DNA polymerase kappa, putative 0.0119 0.0383 0.1107
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0202
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0189 0.0652 0.0652
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0077 0.037
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.177
Mycobacterium tuberculosis Conserved hypothetical protein 0.0025 0.0024 0.0015
Mycobacterium ulcerans hypothetical protein 0.0033 0.0052 0.0044
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0038 0.0104
Schistosoma mansoni glutaminase 0.0543 0.2016 0.2016
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0107 0.0811
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0134
Loa Loa (eye worm) hypothetical protein 0.0122 0.0397 0.0397
Entamoeba histolytica diacylglycerol kinase, putative 0.0102 0.0319 0.0311
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0107 0.0517
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.0219 0.0219
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0083 0.0374
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0205 0.0921
Schistosoma mansoni hypothetical protein 0.0182 0.0627 0.0626
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0106 0.0333 0.0332
Echinococcus granulosus ferritin 0.0026 0.0028 0.0028
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0052 0.0131
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.005 0.0042
Brugia malayi CXXC zinc finger family protein 0.0173 0.0593 0.2668
Echinococcus multilocularis heat shock protein 90 0.0032 0.0051 0.0051
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0016 0.0047
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.022 0.1739
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0054 0.038
Echinococcus multilocularis microtubule associated protein 2 0.1391 0.5281 0.5281
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Entamoeba histolytica hypothetical protein 0.0024 0.002 0.0012
Loa Loa (eye worm) hypothetical protein 0.0141 0.0468 0.0468
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0025 0.0024 0.0128
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0341 0.034
Echinococcus granulosus intestinal type alkaline phosphatase 0.0161 0.0544 0.0544
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0008 0.0023
Leishmania major hypothetical protein, conserved 0.0102 0.0319 0.0916
Schistosoma mansoni terminal deoxycytidyl transferase 0.0106 0.0333 0.0332
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Echinococcus multilocularis histone acetyltransferase MYST2 0.0058 0.0148 0.0148
Plasmodium vivax diacylglycerol kinase, putative 0.0102 0.0319 0.2543
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0134 0.0126
Trypanosoma cruzi DNA damage repair protein, putative 0.0033 0.0052 0.0154
Schistosoma mansoni phosphoglycerate kinase 0.0339 0.123 0.123
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0072 0.0202 0.0194
Trypanosoma cruzi DNA polymerase eta, putative 0.0083 0.0248 0.0728
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0107 0.0811
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0083 0.0987
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0038 0.0288
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0339 0.123 0.1223
Brugia malayi ImpB/MucB/SamB family protein 0.0106 0.0333 0.1497
Mycobacterium ulcerans esterase/lipase LipP 0.0072 0.0202 0.0194
Onchocerca volvulus 0.0021 0.0008 0.0091
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0083 0.0083
Echinococcus multilocularis snurportin 1 0.0307 0.1109 0.1109
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0024
Entamoeba histolytica hypothetical protein, conserved 0.2616 1 1
Trypanosoma brucei unspecified product 0.0073 0.0207 0.0586
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0083 0.0083
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Onchocerca volvulus 0.0238 0.0841 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0028 0.0201
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0024 0.0023
Schistosoma mansoni phosphoglycerate kinase 0.0339 0.123 0.123
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0127 0.0415 0.122
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0008 0.0008
Schistosoma mansoni amine oxidase 0.0025 0.0024 0.0023
Entamoeba histolytica diacylglycerol kinase, putative 0.0102 0.0319 0.0311
Trypanosoma cruzi diacylglycerol kinase, putative 0.0102 0.0319 0.0937
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0031 0.014
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0072 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0009
Brugia malayi Bloom's syndrome protein homolog 0.0066 0.0181 0.0813
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0127 0.0415 0.122
Trypanosoma cruzi Sphingosine kinase 0.0102 0.0319 0.0937
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0202 0.0989
Plasmodium falciparum T-complex protein 1 subunit beta 0.0024 0.002 0.0136
Echinococcus granulosus geminin 0.0182 0.0627 0.0626
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0051 0.0151
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.0732 0.0732
Schistosoma mansoni myst-related protein 0.0024 0.002 0.0019
Echinococcus granulosus neuropeptide receptor A26 0.0919 0.3467 0.3467
Entamoeba histolytica hypothetical protein 0.011 0.0349 0.0341
Echinococcus granulosus Diacylglycerol kinase theta 0.0102 0.0319 0.0318
Leishmania major sphingosine kinase A, B, putative 0.0102 0.0319 0.0916
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0028 0.002
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.163
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0021 0.0008 0.0001
Schistosoma mansoni hypothetical protein 0.0407 0.1495 0.1495
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0131 0.0432 0.0432
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0341 0.1002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0083 0.0083
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0083 0.0374
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0119 0.0111
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0008 0.0026
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0043 0.0043
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0158 0.0537 0.2651
Brugia malayi 6-phosphofructokinase 0.0108 0.0341 0.1533
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0161 0.0544 0.0544
Schistosoma mansoni hypothetical protein 0.0189 0.0652 0.0652
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0427 0.1571 0.4618
Mycobacterium leprae Probable lipase LipE 0.0072 0.0202 0.1588
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0026 0.0114
Brugia malayi Importin beta-1 subunit 0.0029 0.0037 0.0165
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0202
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.1614
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0107 0.0107
Mycobacterium ulcerans hypothetical protein 0.0072 0.0205 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0537 0.1578
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0055 0.0137 0.0136
Trichomonas vaginalis helicase, putative 0.0039 0.0077 0.037
Schistosoma mansoni DNA polymerase eta 0.0156 0.0528 0.0528
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0076 0.022 0.1616
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0051 0.0355
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0108 0.0341 0.0981
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.0115
Echinococcus granulosus neuropeptide s receptor 0.0919 0.3467 0.3467
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0037 0.0037
Loa Loa (eye worm) acetyltransferase 0.0148 0.0497 0.0497
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0025 0.0024 0.0168
Loa Loa (eye worm) mbt repeat family protein 0.0051 0.0121 0.0121
Schistosoma mansoni hypothetical protein 0.0083 0.0247 0.0247
Schistosoma mansoni DNA polymerase IV / kappa 0.0033 0.0052 0.0052
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.0432 0.127
Schistosoma mansoni heat shock protein 0.0032 0.0051 0.0051
Schistosoma mansoni cpg binding protein 0.0173 0.0593 0.0593
Plasmodium vivax endoplasmin, putative 0.0032 0.0051 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0053 0.025
Schistosoma mansoni hypothetical protein 0.0323 0.1169 0.1169
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0024 0.002 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0022
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0008 0.0008
Brugia malayi latrophilin 2 splice variant baaae 0.0407 0.1495 0.673
Loa Loa (eye worm) glutaminase 2 0.0543 0.2016 0.2016
Schistosoma mansoni cpg binding protein 0.0187 0.0646 0.0645
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0027 0.0031 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.011 0.0349 0.0348
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0902 0.3401 1
Loa Loa (eye worm) hypothetical protein 0.0072 0.0205 0.0204
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0156 0.0528 0.1552
Loa Loa (eye worm) T-complex protein 1 0.0024 0.002 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.0027 0.0031 0.0031
Schistosoma mansoni myelin transcription factor 1 myt1 0.0058 0.0148 0.0148
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0102 0.0319 0.0937
Brugia malayi 6-phosphofructokinase 0.0108 0.0341 0.1533
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0083 0.0374
Echinococcus granulosus cpg binding protein 0.0187 0.0646 0.0645
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0339 0.123 0.3617
Onchocerca volvulus 0.0102 0.0319 0.3785
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0121 0.0121
Schistosoma mansoni alkaline phosphatase 0.0161 0.0544 0.0544
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0072 0.0202 0.0194
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.022 0.022
Plasmodium falciparum DNA repair protein REV1, putative 0.0033 0.0052 0.0404
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0102 0.0319 0.1568
Echinococcus granulosus snurportin 1 0.0307 0.1109 0.1109
Schistosoma mansoni heat shock protein 0.0032 0.0051 0.0051
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0035
Echinococcus granulosus ceramide kinase 0.0102 0.0319 0.0318
Trichomonas vaginalis diacylglycerol kinase, putative 0.0102 0.0319 0.1568
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.022 0.1737
Leishmania major phosphoglycerate kinase C, glycosomal 0.0339 0.123 0.3602
Loa Loa (eye worm) hypothetical protein 0.0102 0.0319 0.0318
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0027 0.0031 0.0031
Entamoeba histolytica acyl-CoA synthetase, putative 0.0072 0.0205 0.0197
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.005 0.0125
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0024 0.002 0.0019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0537 0.1578
Leishmania major DNA damage repair protein, putative 0.0033 0.0052 0.0131
Echinococcus granulosus importin subunit beta 1 0.0029 0.0037 0.0037
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0058 0.0148 0.0148
Schistosoma mansoni hypothetical protein 0.0189 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0023
Schistosoma mansoni myst-related protein 0.0024 0.002 0.0019
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0066
Schistosoma mansoni microtubule-associated protein tau 0.1391 0.5281 0.5281
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0083 0.0374
Entamoeba histolytica phosphoglycerate kinase, putative 0.0339 0.123 0.1223
Mycobacterium tuberculosis Conserved protein 0.0072 0.0202 0.0194
Loa Loa (eye worm) hypothetical protein 0.0076 0.022 0.022
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Mycobacterium tuberculosis Probable hydrolase 0.0072 0.0202 0.0194
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0134
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0083 0.0083
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0008 0.0024
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0072 0.0205 0.0197
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0102 0.0319 0.1568
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0076 0.022 0.0648
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Giardia lamblia DINP protein human, muc B family 0.0119 0.0383 0.3073
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0077 0.037
Echinococcus multilocularis 6 phosphofructokinase 0.0108 0.0341 0.034
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0038 0.003
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0077 0.037
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0134 0.1072
Echinococcus granulosus 6 phosphofructokinase 0.0108 0.0341 0.034
Brugia malayi RNA, U transporter 1 0.0082 0.0241 0.1085
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Onchocerca volvulus 0.0021 0.0008 0.0091
Toxoplasma gondii ABC1 family protein 0.0072 0.0202 0.1589
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0038 0.0249
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0038 0.0249
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0102 0.0319 0.0318
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0202
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.0115
Schistosoma mansoni endoplasmin 0.0032 0.0051 0.0051
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0052 0.0154
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0132 0.0435 0.0435
Trichomonas vaginalis diacylglycerol kinase, putative 0.0102 0.0319 0.1568
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0026 0.0076
Echinococcus multilocularis dnaJ subfamily B 0.2466 0.9422 0.9422
Loa Loa (eye worm) RecQ helicase 0.0066 0.0181 0.0181
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.022 0.1737
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0076 0.022 0.022
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0083 0.0374
Trypanosoma brucei hypothetical protein, conserved 0.0072 0.0202 0.0573
Loa Loa (eye worm) hypothetical protein 0.0029 0.0037 0.0037
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.005 0.0347
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0076 0.022 0.1772
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0076 0.022 0.022
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0341 0.1678
Loa Loa (eye worm) hypothetical protein 0.0072 0.0205 0.0204
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0009 0.0009
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0185 0.0185
Echinococcus multilocularis SAM and MBT domain containing protein 0.0051 0.0121 0.0121
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0256 0.0732
Trichomonas vaginalis DNA helicase recq1, putative 0.0066 0.0181 0.0885
Loa Loa (eye worm) hypothetical protein 0.0067 0.0185 0.0185
Plasmodium falciparum diacylglycerol kinase, putative 0.0102 0.0319 0.2573
Echinococcus granulosus microtubule associated protein 2 0.1391 0.5281 0.5281
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0123 0.0115
Echinococcus multilocularis protoporphyrinogen oxidase 0.0025 0.0024 0.0023
Schistosoma mansoni DNA helicase recq5 0.0027 0.0031 0.0031
Brugia malayi PHD-finger family protein 0.0063 0.0169 0.0758
Trypanosoma brucei chrX additional, unordered contigs 0.0033 0.0052 0.0131
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0008 0.0024
Brugia malayi glutaminase DH11.1 0.0543 0.2016 0.9076
Trichomonas vaginalis D-aminoacylase, putative 0.0072 0.0202 0.0989
Loa Loa (eye worm) hypothetical protein 0.0051 0.0121 0.0121
Brugia malayi amine oxidase, flavin-containing family protein 0.0025 0.0024 0.0104
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0016 0.0066
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0077 0.037
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0024 0.0069
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0124 0.0405 0.119
Trypanosoma cruzi Heat shock protein 83, putative 0.0032 0.0051 0.0151
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0102 0.0319 0.0318
Schistosoma mansoni diacylglycerol kinase theta 0.0102 0.0319 0.0318
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0083 0.0083
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0024
Mycobacterium ulcerans phosphoglycerate kinase 0.0339 0.123 0.1223
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0427 0.1571 0.4606
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0083 0.0987
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.022 0.022
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0026 0.0114
Mycobacterium tuberculosis Possible oxidoreductase 0.0025 0.0024 0.0015
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Trypanosoma brucei phosphoglycerate kinase 0.0339 0.123 0.3602
Trichomonas vaginalis DNA polymerase eta, putative 0.0158 0.0537 0.2651
Brugia malayi jmjC domain containing protein 0.0062 0.0166 0.0747
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0031 0.0193
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0058 0.0148 0.0664
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.1109 0.1109
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0107 0.0811
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0077 0.037
Schistosoma mansoni hypothetical protein 0.0189 0.0652 0.0652
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0219 0.0219
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0176
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0027 0.0031 0.0193
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0025 0.0024 0.0126
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0008 0.0035
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.004
Loa Loa (eye worm) hypothetical protein 0.0102 0.0319 0.0318
Loa Loa (eye worm) hypothetical protein 0.0085 0.0252 0.0252
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0008 0.0042
Trichomonas vaginalis chaperonin, putative 0.0024 0.002 0.0083
Trichomonas vaginalis ran, putative 0.0021 0.0008 0.0025
Loa Loa (eye worm) hypothetical protein 0.0054 0.0134 0.0134
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0205 0.1611
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Mycobacterium tuberculosis Conserved protein 0.0072 0.0202 0.0194
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0102 0.0319 0.2543
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0339 0.123 0.3617
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0083 0.0374
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.0212
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0046 0.0103 0.0779
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0341 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0185 0.0185
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0075 0.0552
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0072 0.0205 0.0197
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0537 0.1578
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0028 0.0165
Schistosoma mansoni methyl-cpg binding protein mbd 0.0034 0.0057 0.0057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0083 0.0083
Brugia malayi Calcitonin receptor-like protein seb-1 0.0596 0.2221 1
Echinococcus multilocularis polycomb protein SCMH1 0.0051 0.0121 0.0121
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0083 0.0083
Plasmodium vivax phosphoglycerate kinase, putative 0.0339 0.123 1
Schistosoma mansoni zinc finger protein 0.0052 0.0128 0.0127
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0161 0.0544 0.0544
Plasmodium falciparum phosphoglycerate kinase 0.0339 0.123 1
Echinococcus multilocularis dna polymerase kappa 0.0158 0.0537 0.0536
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0107 0.0517
Trypanosoma brucei phosphoglycerate kinase 0.0339 0.123 0.3602
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0083 0.0083
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0215 0.0753 0.0753
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0189 0.0652 0.0652
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0119 0.0383 0.0376
Schistosoma mansoni bromodomain containing protein 0.0022 0.0011 0.001
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0083 0.0374
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0102 0.0319 0.2543
Plasmodium vivax acetyl-CoA synthetase, putative 0.0021 0.0008 0.0002
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0108 0.0341 0.0333
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0026 0.0114
Onchocerca volvulus Huntingtin homolog 0.0122 0.0397 0.4719
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0083 0.0083
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0102 0.0319 0.0318
Brugia malayi ImpB/MucB/SamB family protein 0.0156 0.0528 0.2376
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0119 0.0111
Leishmania major mitochondrial DNA polymerase beta 0.0902 0.3401 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0054 0.038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0076 0.022 0.0648
Echinococcus granulosus endoplasmin 0.0026 0.0026 0.0025
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0024 0.002 0.0034
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0083 0.0083
Brugia malayi beta-lactamase family protein 0.0072 0.0202 0.0908
Echinococcus multilocularis ceramide kinase 0.0102 0.0319 0.0318
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0008 0.0035
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0339 0.123 1
Trichomonas vaginalis ferritin, putative 0.0026 0.0028 0.0126
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0102 0.0319 0.0916
Trichomonas vaginalis rotamase, putative 0.0033 0.0053 0.025
Schistosoma mansoni hypothetical protein 0.0307 0.1109 0.1109
Toxoplasma gondii hypothetical protein 0.0146 0.0487 0.3918
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0024 0.002 0.0096
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0038 0.0176
Mycobacterium ulcerans DNA polymerase IV 0.0158 0.0537 0.0529
Schistosoma mansoni bromodomain containing protein 0.0139 0.0463 0.0462
Trypanosoma brucei DNA polymerase IV, putative 0.0158 0.0537 0.1558
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0076 0.022 0.0626
Loa Loa (eye worm) hypothetical protein 0.0122 0.0397 0.0397
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0176
Trichomonas vaginalis set domain proteins, putative 0.0238 0.0841 0.4164
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0035
Mycobacterium tuberculosis Diacylglycerol kinase 0.0102 0.0319 0.0311
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0359 0.1307 0.13
Loa Loa (eye worm) MBCTL1 0.0058 0.0148 0.0148
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0028 0.002
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0038 0.0122
Echinococcus granulosus polycomb protein SCMH1 0.0051 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0023
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0458 0.1688 0.1682
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0131 0.0432 0.125
Leishmania major diacylglycerol kinase-like protein 0.0102 0.0319 0.0916
Onchocerca volvulus 0.0051 0.0121 0.1434
Brugia malayi Phosphoglycerate kinase 0.0339 0.123 0.5537
Leishmania major hypothetical protein, conserved 0.0102 0.0319 0.0916
Brugia malayi F/Y-rich N-terminus family protein 0.0058 0.0149 0.0668
Giardia lamblia DNA damage repair protein 0.0033 0.0052 0.0365
Treponema pallidum phosphoglycerate kinase 0.0339 0.123 1
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0038 0.0249
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0007 0.0022
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0083 0.0374
Echinococcus granulosus heat shock protein 90 0.0026 0.0026 0.0025
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0102 0.0319 0.0318
Brugia malayi steroid hormone receptor 0.0041 0.0083 0.0374
Schistosoma mansoni zinc finger protein 0.003 0.0043 0.0043
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0076 0.022 0.0213
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.005 0.0148
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0026 0.0076
Echinococcus multilocularis sphingosine kinase 1 0.2616 1 1
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0026 0.0018
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0072 0.0205 0.1611
Leishmania major importin beta-1 subunit, putative 0.0023 0.0016 0.0024
Plasmodium vivax hypothetical protein, conserved 0.0072 0.0202 0.1589
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0205 0.0921
Brugia malayi T-complex protein 1, beta subunit 0.0024 0.002 0.0086
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0161 0.0544 0.0544
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0205 0.0197
Schistosoma mansoni hypothetical protein 0.0041 0.0084 0.0084
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.022 0.108
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0083 0.0374
Schistosoma mansoni hypothetical protein 0.0189 0.0652 0.0652
Brugia malayi exodeoxyribonuclease III family protein 0.0076 0.022 0.0991
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0026 0.0025
Leishmania major UDP-galactopyranose mutase 0.0025 0.0024 0.0046
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0072 0.0202 0.0194
Brugia malayi ecdysteroid receptor 0.0041 0.0083 0.0374
Trichomonas vaginalis conserved hypothetical protein 0.0102 0.0319 0.1568
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0034
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0083 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Onchocerca volvulus Ceramide kinase 1 homolog 0.0102 0.0319 0.3785
Echinococcus multilocularis heat shock protein 0.0032 0.0051 0.0051
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0083 0.0374
Schistosoma mansoni endoplasmin 0.0032 0.0051 0.0051
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0132 0.0435 0.0435
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0053 0.0238
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0058 0.015 0.1199
Onchocerca volvulus 0.0072 0.0202 0.2399
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Brugia malayi MH2 domain containing protein 0.0247 0.0879 0.3955
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0083 0.0083
Toxoplasma gondii diacylglycerol kinase, putative 0.0102 0.0319 0.2543
Schistosoma mansoni alkaline phosphatase 0.0161 0.0544 0.0544
Mycobacterium ulcerans 6-phosphofructokinase 0.0108 0.0341 0.0333
Echinococcus granulosus alkaline phosphatase 0.0161 0.0544 0.0544
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0189 0.0652 0.0652
Plasmodium falciparum heat shock protein 90 0.0032 0.0051 0.0394
Echinococcus granulosus dna polymerase kappa 0.0158 0.0537 0.0536
Loa Loa (eye worm) hypothetical protein 0.0076 0.022 0.022
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.163
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0062 0.0183
Schistosoma mansoni DNA helicase recq1 0.0027 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0086 0.0256 0.0256
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0134 0.0126
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0008 0.0026
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0127 0.0415 0.122
Trypanosoma brucei Heat shock protein 83, putative 0.0032 0.0051 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0257 0.0735
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0596 0.2221 0.2221
Echinococcus multilocularis endoplasmin 0.0026 0.0026 0.0025
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0124 0.0405 0.119
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0051 0.0051
Onchocerca volvulus 0.0021 0.0008 0.0091
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0083 0.0083
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0189 0.0652 0.0652
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0044 0.0096 0.0096
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0176
Echinococcus multilocularis expressed protein 0.0026 0.0028 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0083 0.0374
Echinococcus granulosus phosphoglycerate kinase 1 0.0339 0.123 0.123
Trichomonas vaginalis bmru protein, putative 0.0102 0.0319 0.1568
Brugia malayi polk-prov protein 0.0086 0.0256 0.1152
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.0333 0.121 0.1203
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0124 0.0405 0.117
Onchocerca volvulus 0.0173 0.0593 0.7048
Trypanosoma cruzi heat shock protein 90, putative 0.0032 0.0051 0.0151
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0119 0.0119
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0062 0.0161
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0083 0.0374
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.0202 0.0201
Toxoplasma gondii propionate-CoA ligase 0.0021 0.0008 0.0002
Schistosoma mansoni hypothetical protein 0.2466 0.9422 0.9422
Brugia malayi Endoplasmin precursor 0.0032 0.0051 0.0229
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0202 0.0594
Loa Loa (eye worm) oxidoreductase 0.0021 0.0008 0.0008
Toxoplasma gondii histone lysine-specific demethylase 0.0025 0.0024 0.0128
Schistosoma mansoni apoferritin-2 0.0026 0.0028 0.0028
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0341 0.0333
Mycobacterium tuberculosis Conserved hypothetical protein 0.0475 0.1756 0.175
Mycobacterium ulcerans hypothetical protein 0.0475 0.1756 0.175
Brugia malayi hypothetical protein 0.011 0.0349 0.1569
Plasmodium vivax heat shock protein 86, putative 0.0032 0.0051 0.0355
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.011 0.0349 0.0348
Schistosoma mansoni diacylglycerol kinase theta 0.0102 0.0319 0.0318
Loa Loa (eye worm) glutaminase 0.0543 0.2016 0.2016
Leishmania major hypothetical protein, conserved 0.003 0.0043 0.0105
Brugia malayi nuclear receptor NHR-88 0.0041 0.0083 0.0374
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0016 0.0066
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0124 0.0405 0.119
Mycobacterium tuberculosis Conserved protein 0.0072 0.0202 0.0194
Echinococcus granulosus histone acetyltransferase MYST2 0.0058 0.0148 0.0148
Echinococcus granulosus zinc finger protein 0.0052 0.0128 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Loa Loa (eye worm) hypothetical protein 0.0156 0.0528 0.0528
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0596 0.2221 0.2221
Trypanosoma brucei DNA polymerase IV, putative 0.0145 0.0486 0.1409
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0062 0.0166 0.0166
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0083 0.0083
Echinococcus multilocularis Diacylglycerol kinase theta 0.0102 0.0319 0.0318
Trypanosoma brucei DNA polymerase kappa, putative 0.0119 0.0383 0.1107
Trypanosoma brucei Sphingosine kinase 0.0102 0.0319 0.0916
Echinococcus granulosus fetal alzheimer antigen falz 0.0055 0.0137 0.0137
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0025 0.0024 0.0023
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0257 0.0735
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0008 0.0007
Entamoeba histolytica hypothetical protein 0.011 0.0349 0.0341
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Trichomonas vaginalis phosphofructokinase, putative 0.0108 0.0341 0.1678
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0028 0.0159
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0072 0.0202 0.0202
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0072 0.0205 0.0197
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0038 0.0288
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0036 0.0035
Giardia lamblia Phosphoglycerate kinase 0.0339 0.123 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0051 0.0121 0.0121
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0083 0.0083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0083 0.0083
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0027 0.0031 0.0031
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0038 0.0176
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Mycobacterium ulcerans diacylglycerol kinase 0.0102 0.0319 0.0311
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0076 0.022 0.0213
Plasmodium falciparum importin beta, putative 0.0029 0.0037 0.0279
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0083 0.0083
Leishmania major phosphoglycerate kinase B, cytosolic 0.0339 0.123 0.3602
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.002 0.0019
Loa Loa (eye worm) transcription factor SMAD2 0.0247 0.0879 0.0878
Trypanosoma cruzi hypothetical protein, conserved 0.0102 0.0319 0.0937
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0008 0.0001
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0027 0.0031 0.0031
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0053 0.0053
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0106 0.0333 0.0332
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0008 0.0007
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0058 0.0148 0.0148
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0083 0.0083
Brugia malayi Bromodomain containing protein 0.008 0.0233 0.1048
Echinococcus granulosus expressed protein 0.0033 0.0053 0.0053
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0124 0.0405 0.119
Schistosoma mansoni sex comb on midleg homolog 0.0051 0.0121 0.0121
Mycobacterium ulcerans dehydrogenase 0.0025 0.0024 0.0015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0096 0.0096
Trypanosoma brucei heat shock protein, putative 0.0032 0.0051 0.0128
Loa Loa (eye worm) hypothetical protein 0.0072 0.0205 0.0204
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0036 0.0064 0.0461
Echinococcus granulosus GPCR family 2 0.0189 0.0652 0.0652
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0028 0.002
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Leishmania major DNA polymerase kappa, putative 0.0033 0.0052 0.0131
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0134 0.0919
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0008 0.0023
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0106 0.0333 0.0332
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.011 0.0349 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0072 0.0202 0.0594
Trypanosoma brucei diacylglycerol kinase, putative 0.0102 0.0319 0.0916
Schistosoma mansoni hypothetical protein 0.0182 0.0627 0.0626
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Schistosoma mansoni ran 0.0021 0.0008 0.0007
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0051 0.0128
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0368 0.1345 0.1344
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0027 0.0031 0.0031
Mycobacterium ulcerans glutaminase 0.0543 0.2016 0.201
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0119 0.0907
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0023
Echinococcus multilocularis cpg binding protein 0.0187 0.0646 0.0645
Leishmania major acetyl-CoA synthetase, putative 0.0021 0.0008 0.0001
Brugia malayi phosphofructokinase 0.0108 0.0341 0.1533
Loa Loa (eye worm) hypothetical protein 0.0339 0.123 0.123
Giardia lamblia Heat shock protein HSP 90-alpha 0.0032 0.0051 0.0355
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0205 0.0581
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0148 0.0497 0.0497
Brugia malayi SWIRM domain containing protein 0.0025 0.0024 0.0104
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0189 0.0652 0.2936
Schistosoma mansoni importin beta-1 0.0029 0.0037 0.0037
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0008 0.0001
Loa Loa (eye worm) CXXC zinc finger family protein 0.0173 0.0593 0.0593
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0052 0.0131
Echinococcus granulosus Diacylglycerol kinase zeta 0.0102 0.0319 0.0318
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0339 0.123 1
Mycobacterium tuberculosis Conserved protein 0.2616 1 1
Trypanosoma brucei DNA damage repair protein, putative 0.0033 0.0052 0.0131
Loa Loa (eye worm) hypothetical protein 0.0153 0.0516 0.0516
Trypanosoma brucei phosphoglycerate kinase, putative 0.0124 0.0405 0.117
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.005 0.0148
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0205 0.0197
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0035 0.0062 0.0161
Entamoeba histolytica recQ family helicase, putative 0.0035 0.0062 0.0055
Loa Loa (eye worm) PHD-finger family protein 0.0041 0.0084 0.0084
Loa Loa (eye worm) endoplasmin 0.0032 0.0051 0.0051
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0038 0.0249
Brugia malayi beta-lactamase family protein 0.0072 0.0202 0.0908
Loa Loa (eye worm) hypothetical protein 0.0098 0.0305 0.0304
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0025 0.0024 0.0015
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0077 0.037
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0072 0.0205 0.0197
Schistosoma mansoni hypothetical protein 0.003 0.0043 0.0043
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0028 0.0161
Brugia malayi Pre-SET motif family protein 0.0033 0.0054 0.0243
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0083 0.0083
Plasmodium falciparum protoporphyrinogen oxidase 0.0025 0.0024 0.0168
Brugia malayi AMP-binding enzyme family protein 0.0072 0.0205 0.0921
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.022 0.0212
Trypanosoma cruzi heat shock protein 85, putative 0.0032 0.0051 0.0151
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0044 0.0096 0.0725
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0033 0.0052 0.0365
Loa Loa (eye worm) latrophilin receptor protein 2 0.0189 0.0652 0.0652
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.0219 0.0219
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0052 0.0154
Loa Loa (eye worm) hypothetical protein 0.0072 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0407 0.1495 0.1495
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0083 0.0374
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0044 0.0096 0.0096
Mycobacterium leprae conserved hypothetical protein 0.0072 0.0202 0.1588
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0102 0.0319 0.1568
Echinococcus multilocularis phosphoglycerate kinase 1 0.0339 0.123 0.123
Trypanosoma cruzi UDP-galactopyranose mutase 0.0025 0.0024 0.0069
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0028 0.0021
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0076 0.022 0.022
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0026 0.0147
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0008 0.0035
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0077 0.037
Brugia malayi Latrophilin receptor protein 2 0.0189 0.0652 0.2936
Trichomonas vaginalis sphingosine kinase, putative 0.0102 0.0319 0.1568
Schistosoma mansoni 6-phosphofructokinase 0.0108 0.0341 0.034
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0202 0.0989
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0054 0.0054
Echinococcus multilocularis zinc finger protein 0.0052 0.0128 0.0127
Echinococcus granulosus expressed protein 0.0026 0.0028 0.0028
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0185 0.0185
Trypanosoma cruzi DNA polymerase kappa, putative 0.0158 0.0537 0.1578
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0075 0.0067
Onchocerca volvulus 0.0072 0.0205 0.2432
Schistosoma mansoni ferritin light chain 0.0026 0.0028 0.0028
Brugia malayi jmjC domain containing protein 0.0076 0.0219 0.0984
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.005 0.0125
Mycobacterium ulcerans acyl-CoA synthetase 0.0072 0.0205 0.0197
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0024 0.0128
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0131 0.0432 0.0432
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Echinococcus multilocularis dna polymerase eta 0.0156 0.0528 0.0528
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0028 0.002
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0339 0.123 1
Brugia malayi mbt repeat family protein 0.0051 0.0121 0.0543
Mycobacterium ulcerans lipase LipD 0.0072 0.0202 0.0194
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0083 0.0083
Schistosoma mansoni hypothetical protein 0.0102 0.0319 0.0318
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.037
Trypanosoma brucei DNA polymerase eta, putative 0.0156 0.0528 0.1533
Loa Loa (eye worm) hypothetical protein 0.2616 1 1
Brugia malayi Ceramide kinase 0.0102 0.0319 0.1433
Trichomonas vaginalis ap endonuclease, putative 0.0076 0.022 0.108
Entamoeba histolytica acyl-coA synthetase, putative 0.0072 0.0205 0.0197
Trypanosoma brucei heat shock protein 90, putative 0.0032 0.0051 0.0128
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0021 0.0008 0.0002
Brugia malayi diacylglycerol kinase 0.0102 0.0319 0.1433
Plasmodium falciparum diacylglycerol kinase, putative 0.0102 0.0319 0.2573
Schistosoma mansoni jumonji domain containing protein 0.0062 0.0166 0.0166
Brugia malayi Eye-specific diacylglycerol kinase 0.0102 0.0319 0.1433
Schistosoma mansoni apoferritin-2 0.0026 0.0028 0.0028
Trichomonas vaginalis bmru protein, putative 0.0102 0.0319 0.1568
Trichomonas vaginalis penicillin-binding protein, putative 0.0072 0.0202 0.0989
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0131 0.0432 0.0424
Schistosoma mansoni ap endonuclease 0.0076 0.022 0.022
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0106 0.0333 0.0332
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0205 0.0581
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0026 0.0018
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0038 0.0249
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0062 0.0166 0.0166
Entamoeba histolytica phosphofructokinase, putative 0.0108 0.0341 0.0333
Echinococcus multilocularis geminin 0.0182 0.0627 0.0626
Echinococcus granulosus lysine specific histone demethylase 1A 0.0025 0.0024 0.0023
Brugia malayi beta-lactamase 0.0072 0.0202 0.0908
Leishmania major heat shock protein 83-1 0.0032 0.0051 0.0128
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0025 0.0024 0.0023
Echinococcus multilocularis lysine specific demethylase 5A 0.0062 0.0166 0.0166
Leishmania major DNA polymerase eta, putative 0.0156 0.0528 0.1533
Trypanosoma cruzi diacylglycerol kinase, putative 0.0102 0.0319 0.0937
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0054 0.0054
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0024 0.0128
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0083 0.0374
Schistosoma mansoni coup transcription factor 0.0041 0.0083 0.0083
Echinococcus multilocularis transcription factor Dp 1 0.0076 0.0219 0.0219
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0072 0.0202 0.0908
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0339 0.123 0.6096
Trypanosoma brucei phosphoglycerate kinase 0.0124 0.0405 0.117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0083 0.0083
Brugia malayi nuclear receptor RXR 0.0022 0.0009 0.004
Brugia malayi hypothetical protein 0.0122 0.0397 0.1787
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0051 0.0043
Loa Loa (eye worm) MH2 domain-containing protein 0.0247 0.0879 0.0878
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0119 0.0383 0.1107
Loa Loa (eye worm) hypothetical protein 0.0041 0.0083 0.0083
Mycobacterium ulcerans monoamine oxidase 0.0025 0.0024 0.0015
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0024 0.002 0.0019
Trypanosoma cruzi ISWI complex protein 0.003 0.0043 0.0128
Trypanosoma cruzi Sphingosine kinase 0.0102 0.0319 0.0937
Loa Loa (eye worm) hypothetical protein 0.0189 0.0652 0.0652
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0083 0.0248 0.1962
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0083 0.0987
Echinococcus granulosus dnaJ subfamily B 0.2466 0.9422 0.9422
Giardia lamblia Grp94/Hsp90 0.0026 0.0026 0.0147
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0075 0.0075
Entamoeba histolytica heat shock protein 90, putative 0.0032 0.0051 0.0043
Giardia lamblia Sgs1 DNA helicase, putative 0.0027 0.0031 0.0193
Brugia malayi mbt repeat family protein 0.0051 0.0121 0.0543
Echinococcus multilocularis alkaline phosphatase 0.0161 0.0544 0.0544
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0076 0.022 0.0213
Trypanosoma brucei DNA polymerase kappa, putative 0.0158 0.0537 0.1558
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0051 0.0355
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0148 0.0497 0.0497
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0131 0.0432 0.0432
Loa Loa (eye worm) hypothetical protein 0.0025 0.0024 0.0023
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0102 0.0319 0.0937
Toxoplasma gondii t-complex protein beta subunit 0.0024 0.002 0.0096
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0024 0.002 0.0012
Leishmania major 4-coumarate:coa ligase-like protein 0.0072 0.0205 0.0581
Plasmodium vivax importin-beta 2, putative 0.0029 0.0037 0.0239
Plasmodium falciparum zinc finger protein, putative 0.0024 0.002 0.0136
Brugia malayi Probable ClpP-like protease 0.0076 0.022 0.0989
Entamoeba histolytica hypothetical protein 0.011 0.0349 0.0341
Trichomonas vaginalis DNA helicase recq, putative 0.0035 0.0062 0.0295
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0902 0.3401 1
Loa Loa (eye worm) phosphofructokinase 0.0108 0.0341 0.034
Brugia malayi Pre-SET motif family protein 0.0209 0.0732 0.3294
Echinococcus multilocularis beta LACTamase domain containing family member 0.0072 0.0202 0.0202
Mycobacterium tuberculosis Probable esterase LipL 0.0072 0.0202 0.0194
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.022 0.022
Echinococcus multilocularis heat shock protein 90 0.0026 0.0026 0.0025
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0083 0.0083
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0072 0.0202 0.0194
Schistosoma mansoni blooms syndrome DNA helicase 0.0052 0.0127 0.0127
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0463 0.0463
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0037 0.0086
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0256 0.0732
Trichomonas vaginalis rotamase, putative 0.0032 0.005 0.0235
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0083 0.0083
Schistosoma mansoni ran 0.0021 0.0008 0.0007
Echinococcus multilocularis GPCR, family 2 0.0189 0.0652 0.0652
Trypanosoma brucei DNA polymerase kappa, putative 0.0086 0.0257 0.0735
Echinococcus multilocularis neuropeptide s receptor 0.0919 0.3467 0.3467
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0131 0.0432 0.125
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0051 0.0121 0.1434
Trypanosoma brucei DNA polymerase IV, putative 0.0158 0.0537 0.1558
Loa Loa (eye worm) hypothetical protein 0.0022 0.0009 0.0009
Brugia malayi hypothetical protein 0.0022 0.0009 0.004
Echinococcus granulosus transcription factor Dp 1 0.0076 0.0219 0.0219
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0131 0.0432 0.1943
Loa Loa (eye worm) hypothetical protein 0.0058 0.0148 0.0148
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0054 0.0054
Mycobacterium tuberculosis Probable lipase LipD 0.0072 0.0202 0.0194
Loa Loa (eye worm) 6-phosphofructokinase 0.0108 0.0341 0.034
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0025 0.0024 0.0128
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0083 0.0083
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0083 0.0083
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0902 0.3401 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.13 uM Inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182
IC50 (binding) = 22.5 uM Inhibition of recombinant human MAO-A assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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