Detailed information for compound 1783251

Basic information

Technical information
  • TDR Targets ID: 1783251
  • Name: 6-hydroxy-3,4-dihydro-1H-quinolin-2-one
  • MW: 163.173 | Formula: C9H9NO2
  • H donors: 2 H acceptors: 2 LogP: 0.71 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)ccc(c2)O
  • InChi: 1S/C9H9NO2/c11-7-2-3-8-6(5-7)1-4-9(12)10-8/h2-3,5,11H,1,4H2,(H,10,12)
  • InChiKey: HOSGXJWQVBHGLT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 6-hydroxy-3,4-dihydrocarbostyril
  • 54197-66-9
  • ZINC03957998

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0126 0.0157
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0026 0.0028 0.0024
Schistosoma mansoni endoplasmin 0.0033 0.0056 0.0056
Echinococcus granulosus expressed protein 0.0026 0.0028 0.0028
Leishmania major DNA polymerase kappa, putative 0.0039 0.0082 0.02
Schistosoma mansoni sphingosine kinase A B 0.1978 0.805 0.805
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0088 0.0088
Trypanosoma cruzi hypothetical protein, conserved 0.0077 0.0238 0.0643
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0014 0.0007
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0077 0.0238 0.0238
Loa Loa (eye worm) T-complex protein 1 0.0023 0.0017 0.0021
Trypanosoma brucei phosphoglycerate kinase 0.0127 0.0442 0.1177
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0471 0.1257
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Schistosoma mansoni cpg binding protein 0.0172 0.0629 0.0629
Schistosoma mansoni hypothetical protein 0.0179 0.0658 0.0658
Echinococcus granulosus lysine specific demethylase 5A 0.0075 0.023 0.023
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.011 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0073 0.0221 0.0275
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0009 0.004
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0039 0.0264
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0073 0.022 0.0262
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0014 0.0043
Brugia malayi beta-lactamase family protein 0.0073 0.0221 0.102
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0041 0.0088 0.0088
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.024 0.109
Schistosoma mansoni hypothetical protein 0.0025 0.0022 0.0022
Echinococcus granulosus dna polymerase eta 0.0203 0.0755 0.0755
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0221 0.102
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0357 0.1632
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0916 0.3688 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0081 0.036
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0126 0.0126
Plasmodium vivax importin-beta 2, putative 0.0029 0.004 0.0238
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0134 0.0471 0.1257
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0221 0.0264
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0162 0.0586 0.0586
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0127 0.0442 0.1177
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0106 0.0106
Echinococcus granulosus neuropeptide s receptor 0.0917 0.3689 0.3689
Brugia malayi diacylglycerol kinase 0.0077 0.0238 0.1096
Brugia malayi ImpB/MucB/SamB family protein 0.0203 0.0755 0.3478
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Schistosoma mansoni rotamase 0.0033 0.0058 0.0058
Loa Loa (eye worm) hypothetical protein 0.0077 0.0238 0.0295
Mycobacterium tuberculosis Conserved protein 0.0073 0.0221 0.0264
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Trypanosoma brucei phosphoglycerate kinase, putative 0.0127 0.0442 0.1177
Loa Loa (eye worm) histone methyltransferase 0.0054 0.0145 0.018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0012
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0073 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0012
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0916 0.3688 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0041 0.0088 0.0407
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0041 0.0088 0.0088
Trichomonas vaginalis dullard protein, putative 0.0025 0.0023 0.0091
Loa Loa (eye worm) phosphofructokinase 0.0106 0.0357 0.0444
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0046 0.0112 0.0774
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0028 0.0114
Leishmania major phosphoglycerate kinase B, cytosolic 0.0345 0.134 0.3618
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.014 0.0496 0.0605
Schistosoma mansoni DNA polymerase IV / kappa 0.0039 0.0082 0.0082
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0127 0.0442 0.1197
Echinococcus multilocularis dnaJ subfamily B 0.2452 1 1
Plasmodium falciparum diacylglycerol kinase, putative 0.0077 0.0238 0.1752
Giardia lamblia DINP protein human, muc B family 0.014 0.0496 0.3656
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.024 0.1766
Plasmodium vivax DNA repair protein REV1, putative 0.0039 0.0082 0.0553
Loa Loa (eye worm) hypothetical protein 0.0073 0.0221 0.0275
Onchocerca volvulus 0.0041 0.0088 0.0976
Schistosoma mansoni hypothetical protein 0.0084 0.0267 0.0267
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0077 0.024 0.1734
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0073 0.022 0.0262
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0059 0.0059
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0077 0.0238 0.1081
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.0334 0.0885
Brugia malayi Phosphoglycerate kinase 0.0127 0.0442 0.2037
Brugia malayi diacylglycerol kinase 0.0077 0.0238 0.1096
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0221 0.0578
Trichomonas vaginalis conserved hypothetical protein 0.0077 0.0238 0.1081
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Trichomonas vaginalis sphingosine kinase, putative 0.0077 0.0238 0.1081
Echinococcus granulosus fetal alzheimer antigen falz 0.0056 0.0149 0.0149
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0221 0.0264
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0056 0.0058
Entamoeba histolytica hypothetical protein 0.0024 0.0021 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.018 0.0662 0.1794
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0357 0.0444
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.0154 0.0154
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0039 0.0227
Treponema pallidum heat shock protein 90 0.0026 0.0028 0.0104
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0221 0.0275
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0026 0.0028 0.0024
Leishmania major hypothetical protein, conserved 0.0077 0.0238 0.0622
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0081 0.036
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0088 0.0407
Echinococcus granulosus CTD small phosphatase protein like 0.0025 0.0023 0.0023
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0069 0.0185
Leishmania major DNA polymerase kappa, putative 0.014 0.0496 0.1323
Echinococcus multilocularis Diacylglycerol kinase theta 0.0077 0.0238 0.0238
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0023 0.0091
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0056 0.0149 0.0149
Echinococcus multilocularis GPCR, family 2 0.011 0.0375 0.0375
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0054 0.0343
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0212 0.0793 0.0793
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0116 0.0396 0.2912
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0009 0.0024
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Brugia malayi ImpB/MucB/SamB family protein 0.0126 0.0441 0.2031
Trypanosoma brucei phosphoglycerate kinase 0.0345 0.134 0.3618
Trichomonas vaginalis DNA helicase recq, putative 0.0067 0.0197 0.0894
Mycobacterium ulcerans DNA polymerase IV 0.018 0.0662 0.0813
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0077 0.0238 0.0622
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0039 0.0039
Plasmodium vivax T-complex protein 1 subunit beta, putative 0.0023 0.0017 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0014 0.0016
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0041 0.0088 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0078 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0221 0.0599
Loa Loa (eye worm) hypothetical protein 0.0123 0.0428 0.0532
Schistosoma mansoni hypothetical protein 0.0031 0.0049 0.0049
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0134 0.0471 0.0471
Loa Loa (eye worm) hypothetical protein 0.1978 0.805 1
Trypanosoma cruzi heat shock protein 90, putative 0.0033 0.0056 0.0149
Plasmodium falciparum phosphoglycerate kinase 0.0345 0.134 1
Schistosoma mansoni alkaline phosphatase 0.0162 0.0586 0.0586
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0073 0.022 0.0262
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0039 0.0185
Giardia lamblia Heat shock protein HSP 90-alpha 0.0033 0.0056 0.0351
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0088 0.0407
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Echinococcus granulosus histone lysine methyltransferase setb 0.0068 0.0201 0.0201
Schistosoma mansoni myst-related protein 0.0024 0.0021 0.0021
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Schistosoma mansoni importin beta-1 0.0029 0.004 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Schistosoma mansoni transcription factor LCR-F1 0.0073 0.0221 0.0221
Echinococcus granulosus chaperonin containing TCP1 subunit 2 beta 0.0023 0.0017 0.0017
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0077 0.0238 0.1081
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.023 0.023
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0009 0.0022
Schistosoma mansoni DNA polymerase eta 0.0203 0.0755 0.0755
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0063 0.0063
Brugia malayi ecdysteroid receptor 0.0041 0.0088 0.0407
Trichomonas vaginalis bmru protein, putative 0.0077 0.0238 0.1081
Echinococcus granulosus expressed protein 0.0033 0.0058 0.0058
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0009 0.0009
Echinococcus multilocularis Carboxy terminal domain RNA polymerase II 0.0025 0.0023 0.0023
Echinococcus multilocularis ferritin 0.0026 0.0028 0.0028
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0077 0.0238 0.0643
Schistosoma mansoni myst-related protein 0.0024 0.0021 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.022 0.0262
Plasmodium vivax diacylglycerol kinase, putative 0.0077 0.0238 0.172
Toxoplasma gondii histone lysine methyltransferase SET1 0.0336 0.13 0.9704
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0041 0.0088 0.0407
Onchocerca volvulus Protein ultraspiracle homolog 0.0041 0.0088 0.0976
Loa Loa (eye worm) hypothetical protein 0.0349 0.1356 0.1684
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0221 0.0264
Plasmodium falciparum heat shock protein 90 0.0033 0.0056 0.0389
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0357 0.0357
Schistosoma mansoni diacylglycerol kinase theta 0.0077 0.0238 0.0238
Mycobacterium ulcerans hypothetical protein 0.0039 0.0082 0.0091
Trichomonas vaginalis DNA polymerase eta, putative 0.018 0.0662 0.3041
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0174 0.0174
Echinococcus multilocularis 0.0025 0.0023 0.0023
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0126 0.0126
Echinococcus granulosus methyl CpG binding domain protein 2 0.0035 0.0063 0.0063
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.022 0.0573
Plasmodium falciparum zinc finger protein, putative 0.0024 0.0021 0.0127
Entamoeba histolytica hypothetical protein 0.0073 0.0221 0.0263
Trichomonas vaginalis ferritin, putative 0.0026 0.0028 0.0115
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0039 0.0038
Loa Loa (eye worm) hypothetical protein 0.0073 0.0221 0.0275
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.022 0.0573
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0162 0.0586 0.0586
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0081 0.036
Onchocerca volvulus Ceramide kinase 1 homolog 0.0077 0.0238 0.2627
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0221 0.0264
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0009 0.0009
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0035 0.0198
Loa Loa (eye worm) hypothetical protein 0.0028 0.0035 0.0044
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0041 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0078 0.0241 0.0299
Onchocerca volvulus 0.0239 0.0905 1
Toxoplasma gondii t-complex protein beta subunit 0.0023 0.0017 0.0064
Schistosoma mansoni endoplasmin 0.0033 0.0056 0.0056
Echinococcus granulosus phosphoglycerate kinase 1 0.0345 0.134 0.134
Echinococcus multilocularis FTZ F1 alpha 0.0041 0.0088 0.0088
Echinococcus multilocularis importin subunit beta 1 0.0029 0.004 0.004
Brugia malayi mbt repeat family protein 0.005 0.0126 0.0581
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0126 0.0441 0.0537
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0077 0.024 0.1699
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0059 0.0375
Schistosoma mansoni nuclear hormone receptor 0.0041 0.0088 0.0088
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0054 0.0144 0.0168
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0009 0.0022
Loa Loa (eye worm) hypothetical protein 0.01 0.0331 0.0411
Mycobacterium ulcerans bacterioferritin BfrB 0.0026 0.0028 0.0024
Schistosoma mansoni methyl-cpg binding protein mbd 0.0035 0.0063 0.0063
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0082 0.02
Giardia lamblia Grp94/Hsp90 0.0026 0.0028 0.0145
Echinococcus granulosus cpg binding protein 0.0186 0.0685 0.0685
Trichomonas vaginalis helicase, putative 0.0039 0.0081 0.036
Loa Loa (eye worm) hypothetical protein 0.0073 0.0221 0.0275
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0041 0.0088 0.0407
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Trypanosoma brucei T-complex protein 1, beta subunit, putative 0.0023 0.0017 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0167 0.0607 0.1627
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0077 0.0238 0.172
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0201 0.0201
Brugia malayi Latrophilin receptor protein 2 0.011 0.0375 0.1729
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0304 0.0802
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.0153
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Mycobacterium tuberculosis Conserved hypothetical protein 0.0483 0.1905 0.2358
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0026 0.0028 0.0053
Entamoeba histolytica phosphoglycerate kinase, putative 0.0345 0.134 0.1655
Schistosoma mansoni heat shock protein 0.0033 0.0056 0.0056
Toxoplasma gondii phosphoglycerate kinase PGKII 0.0345 0.134 1
Brugia malayi 6-phosphofructokinase 0.0106 0.0357 0.1646
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0014 0.0007
Echinococcus granulosus dna polymerase kappa 0.018 0.0662 0.0662
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0106 0.0106
Onchocerca volvulus 0.0021 0.0009 0.0097
Trypanosoma brucei diacylglycerol kinase, putative 0.0077 0.0238 0.0622
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0007 0.0016
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0039 0.0225
Brugia malayi Endoplasmin precursor 0.0033 0.0056 0.0256
Mycobacterium ulcerans DNA polymerase IV 0.018 0.0662 0.0813
Schistosoma mansoni cpg binding protein 0.0186 0.0685 0.0685
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0027
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0134 0.0473 0.0473
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0073 0.0221 0.0221
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0054 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.018 0.0662 0.1794
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0106 0.0489
Plasmodium vivax endoplasmin, putative 0.0033 0.0056 0.0352
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0126 0.0441 0.0441
Loa Loa (eye worm) transcription factor SMAD2 0.0246 0.0934 0.1161
Schistosoma mansoni hypothetical protein 0.031 0.1194 0.1194
Brugia malayi hypothetical protein 0.0077 0.0238 0.1096
Trypanosoma brucei Sphingosine kinase 0.0077 0.0238 0.0622
Schistosoma mansoni ferritin light chain 0.0026 0.0028 0.0028
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0035 0.0162
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0041 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Trypanosoma cruzi DNA polymerase eta, putative 0.0203 0.0755 0.2045
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0054 0.0124
Mycobacterium tuberculosis Conserved protein 0.1978 0.805 1
Brugia malayi PHD-finger family protein 0.0064 0.0183 0.0845
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0041 0.0088 0.0088
Trypanosoma cruzi DNA damage repair protein, putative 0.0039 0.0082 0.0222
Entamoeba histolytica hypothetical protein 0.0024 0.0018 0.0011
Loa Loa (eye worm) RecQ helicase 0.0067 0.0197 0.0245
Schistosoma mansoni hypothetical protein 0.011 0.0375 0.0375
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0434 0.1704 0.4607
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0434 0.1704 0.4607
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.0357 0.0947
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0023 0.0062
Entamoeba histolytica deoxycytidyl transferase, putative 0.0126 0.0441 0.0537
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0021 0.0009 0.0039
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0041 0.0088 0.011
Plasmodium falciparum importin beta, putative 0.0029 0.004 0.0275
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0434 0.1704 0.4619
Schistosoma mansoni hypothetical protein 0.011 0.0375 0.0375
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0077 0.024 0.0287
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0054 0.0146
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0081 0.036
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.0154 0.0154
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0134 0.0471 0.0471
Loa Loa (eye worm) glutaminase 2 0.0547 0.2169 0.2695
Loa Loa (eye worm) hypothetical protein 0.005 0.0126 0.0157
Loa Loa (eye worm) acetyltransferase 0.0146 0.0522 0.0649
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0054 0.0144 0.0179
Entamoeba histolytica hypothetical protein 0.0073 0.0221 0.0263
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.0357 0.0357
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0018 0.0066
Trypanosoma cruzi diacylglycerol kinase, putative 0.0077 0.0238 0.0643
Schistosoma mansoni blooms syndrome DNA helicase 0.0053 0.0139 0.0139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0077 0.024 0.024
Schistosoma mansoni hypothetical protein 0.011 0.0375 0.0375
Entamoeba histolytica diacylglycerol kinase, putative 0.0077 0.0238 0.0285
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0041 0.0088 0.0088
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0046 0.0112 0.0774
Schistosoma mansoni hypothetical protein 0.0319 0.1231 0.1231
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0035 0.0035
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Brugia malayi Importin beta-1 subunit 0.0029 0.004 0.0186
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0056 0.0149
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0073 0.0221 0.0221
Echinococcus multilocularis heat shock protein 90 0.0026 0.0028 0.0028
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0221 0.1005
Trichomonas vaginalis rotamase, putative 0.0033 0.0058 0.025
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.0334 0.0885
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0017 0.0017
Trichomonas vaginalis dullard protein, putative 0.0025 0.0023 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.022 0.0262
Schistosoma mansoni cpg binding protein 0.0186 0.0685 0.0685
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0077 0.0238 0.0295
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0041 0.0088 0.0088
Schistosoma mansoni retinoic acid receptor RXR 0.0041 0.0088 0.0088
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0221 0.0221
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Echinococcus granulosus bloom syndrome protein 0.0067 0.0197 0.0197
Trichomonas vaginalis antibiotic synthetase, putative 0.0021 0.0009 0.0024
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0077 0.0238 0.0238
Giardia lamblia DNA damage repair protein 0.0039 0.0082 0.0552
Schistosoma mansoni coup transcription factor 0.0041 0.0088 0.0088
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0081 0.036
Loa Loa (eye worm) ceramide kinase 0.0077 0.0238 0.0295
Brugia malayi nuclear receptor NHR-88 0.0041 0.0088 0.0407
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0129 0.0451 0.1221
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0054 0.0124
Brugia malayi Pre-SET motif family protein 0.0033 0.0059 0.027
Brugia malayi Steroid receptor seven-up type 2 0.0041 0.0088 0.0407
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0041 0.0088 0.0407
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0041 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0068 0.0201 0.0249
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0054 0.0144 0.0168
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0056 0.0127
Echinococcus granulosus geminin 0.0179 0.0658 0.0658
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0357 0.0433
Loa Loa (eye worm) CXXC zinc finger family protein 0.0172 0.0629 0.0781
Echinococcus granulosus ecdysone induced protein 78C 0.0041 0.0088 0.0088
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0253 0.1166
Schistosoma mansoni hypothetical protein 0.0239 0.0902 0.0902
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Loa Loa (eye worm) hypothetical protein 0.0077 0.0238 0.0295
Trichomonas vaginalis sphingosine kinase, putative 0.0077 0.0238 0.1081
Loa Loa (eye worm) hypothetical protein 0.0155 0.0557 0.0692
Trichomonas vaginalis rotamase, putative 0.0032 0.0054 0.0235
Echinococcus multilocularis dna polymerase eta 0.0203 0.0755 0.0755
Brugia malayi Diacylglycerol kinase protein 2 0.0077 0.0238 0.1096
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0035 0.0198
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0021 0.0009 0.0022
Echinococcus granulosus FTZ F1 alpha 0.0041 0.0088 0.0088
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Onchocerca volvulus Huntingtin homolog 0.0123 0.0428 0.4729
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0026 0.0028 0.0024
Schistosoma mansoni glutaminase 0.0547 0.2169 0.2169
Leishmania major diacylglycerol kinase, putative 0.0077 0.0238 0.0622
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0045 0.0045
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0126 0.0441 0.0441
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0221 0.0599
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0011
Schistosoma mansoni zinc finger protein 0.0053 0.0139 0.0139
Echinococcus granulosus transcription factor Dp 1 0.0077 0.024 0.024
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0081 0.036
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0221 0.1596
Schistosoma mansoni bromodomain containing protein 0.0022 0.0011 0.0011
Loa Loa (eye worm) heat shock protein 90 0.0033 0.0056 0.0069
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0253 0.0253
Mycobacterium ulcerans heat shock protein 90 0.0026 0.0028 0.0024
Plasmodium vivax phosphoglycerate kinase, putative 0.0345 0.134 1
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0009 0.004
Loa Loa (eye worm) jmjC domain-containing protein 0.0075 0.023 0.0286
Toxoplasma gondii hypothetical protein 0.0148 0.0529 0.3906
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0134 0.0471 0.2173
Echinococcus granulosus intestinal type alkaline phosphatase 0.0162 0.0586 0.0586
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0035 0.0035
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0014 0.0007
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0471 0.1277
Loa Loa (eye worm) steroid hormone receptor 0.0041 0.0088 0.011
Trichomonas vaginalis set domain proteins, putative 0.0239 0.0905 0.4162
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0345 0.134 0.6169
Onchocerca volvulus 0.0077 0.0238 0.2627
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0212 0.0793 0.0793
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0021 0.0009 0.004
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0039 0.0163
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.011 0.0375 0.1729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0106
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0039 0.0163
Treponema pallidum bacterioferrin (TpF1) 0.0026 0.0028 0.0105
Loa Loa (eye worm) hypothetical protein 0.0054 0.0144 0.0179
Schistosoma mansoni phosphoglycerate kinase 0.0345 0.134 0.134
Echinococcus granulosus histone acetyltransferase KAT2B 0.0046 0.0112 0.0112
Plasmodium vivax diacylglycerol kinase, putative 0.0077 0.0238 0.172
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0129 0.0451 0.1221
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0366 0.1427 0.1427
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0023 0.0023
Schistosoma mansoni hypothetical protein 0.0077 0.0238 0.0238
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0041 0.0088 0.0088
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0028 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0021 0.0007 0.0016
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0039 0.0163
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.0345 0.134 1
Trypanosoma brucei Heat shock protein 83, putative 0.0033 0.0056 0.0127
Plasmodium falciparum acyl-CoA synthetase 0.0054 0.0144 0.1052
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0253 0.0253
Toxoplasma gondii ABC1 family protein 0.0073 0.0221 0.1596
Onchocerca volvulus 0.0021 0.0009 0.0097
Echinococcus granulosus endoplasmin 0.0026 0.0028 0.0028
Mycobacterium ulcerans hypothetical protein 0.0073 0.022 0.0262
Entamoeba histolytica hypothetical protein, conserved 0.1978 0.805 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0026 0.0028 0.0105
Schistosoma mansoni hypothetical protein 0.0073 0.0221 0.0221
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0039 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0039 0.0163
Onchocerca volvulus Bile acid receptor homolog 0.0041 0.0088 0.0976
Leishmania major diacylglycerol kinase-like protein 0.0077 0.0238 0.0622
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.022 0.1584
Schistosoma mansoni zinc finger protein 0.0031 0.0049 0.0049
Echinococcus granulosus heat shock protein 90 0.0033 0.0056 0.0056
Brugia malayi Bromodomain containing protein 0.0165 0.0601 0.277
Onchocerca volvulus 0.0025 0.0024 0.0268
Brugia malayi jmjC domain containing protein 0.0061 0.0174 0.0801
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0082 0.0222
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0073 0.022 0.0262
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Schistosoma mansoni alkaline phosphatase 0.0162 0.0586 0.0586
Brugia malayi phosphofructokinase 0.0106 0.0357 0.1646
Schistosoma mansoni hypothetical protein 0.0042 0.0093 0.0093
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0345 0.134 0.3632
Loa Loa (eye worm) hypothetical protein 0.0073 0.0221 0.0275
Schistosoma mansoni RAR-like nuclear receptor 0.0041 0.0088 0.0088
Trypanosoma brucei ISWI complex protein 0.0031 0.0049 0.0108
Mycobacterium ulcerans phosphoglycerate kinase 0.0345 0.134 0.1655
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0126 0.0126
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0126 0.1392
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0041 0.0088 0.0088
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0041 0.0088 0.0088
Mycobacterium ulcerans glutaminase 0.0547 0.2169 0.2687
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0078 0.0556
Leishmania major DNA damage repair protein, putative 0.0039 0.0082 0.02
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0345 0.134 0.3632
Loa Loa (eye worm) PHD-finger family protein 0.0042 0.0093 0.0116
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.0522 0.0522
Brugia malayi CXXC zinc finger family protein 0.0172 0.0629 0.2899
Loa Loa (eye worm) hypothetical protein 0.0345 0.134 0.1664
Leishmania major DNA polymerase eta, putative 0.0203 0.0755 0.2027
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.0787 0.0978
Toxoplasma gondii Dullard family phosphatase domain-containing protein 0.0025 0.0023 0.011
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.0522 0.2407
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.0357 0.0433
Trichomonas vaginalis heat shock protein, putative 0.0033 0.0056 0.024
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0021 0.0009 0.0009
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0077 0.0238 0.172
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0041 0.0088 0.0407
Trichomonas vaginalis ran, putative 0.0021 0.0009 0.0025
Echinococcus granulosus GPCR family 2 0.011 0.0375 0.0375
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0077 0.024 0.0627
Brugia malayi photoreceptor-specific nuclear receptor 0.0041 0.0088 0.0407
Trypanosoma cruzi DNA polymerase eta, putative 0.0116 0.0396 0.1074
Schistosoma mansoni nuclear lim interactor-interacting factor (nli-interacting factor) (nli-if) 0.0025 0.0023 0.0023
Mycobacterium tuberculosis Conserved protein 0.0073 0.0221 0.0264
Entamoeba histolytica recQ family helicase, putative 0.0036 0.0069 0.0074
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0106 0.0106
Leishmania major mitochondrial DNA polymerase beta 0.0916 0.3688 1
Loa Loa (eye worm) hypothetical protein 0.0143 0.0511 0.0634
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0077 0.024 0.0298
Onchocerca volvulus 0.0021 0.0009 0.0097
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0045 0.0108 0.0744
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0174 0.0174
Loa Loa (eye worm) beta-lactamase 0.0073 0.0221 0.0275
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0357 0.0433
Schistosoma mansoni jumonji/arid domain-containing protein 0.0075 0.023 0.023
Onchocerca volvulus 0.0073 0.022 0.2427
Trypanosoma brucei heat shock protein 90, putative 0.0033 0.0056 0.0127
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0039 0.0163
Loa Loa (eye worm) MBCTL1 0.0057 0.0154 0.0192
Echinococcus multilocularis endoplasmin 0.0026 0.0028 0.0028
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0023 0.011
Onchocerca volvulus 0.005 0.0126 0.1392
Schistosoma mansoni microtubule-associated protein tau 0.1386 0.5618 0.5618
Leishmania major hypothetical protein, conserved 0.0077 0.0238 0.0622
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0174 0.0174
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.0154 0.0154
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0082 0.0222
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0009 0.0009
Mycobacterium leprae conserved hypothetical protein 0.0023 0.0014 0.0043
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0045 0.0106 0.0727
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0012
Brugia malayi heat shock protein 90 0.0033 0.0056 0.0256
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0221 0.0221
Brugia malayi glutaminase DH11.1 0.0547 0.2169 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0041 0.0088 0.0088
Mycobacterium ulcerans diacylglycerol kinase 0.0077 0.0238 0.0285
Entamoeba histolytica diacylglycerol kinase, putative 0.0077 0.0238 0.0285
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Brugia malayi hypothetical protein 0.0123 0.0428 0.1973
Trichomonas vaginalis chaperonin-60kD, ch60, putative 0.0023 0.0017 0.0063
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0026 0.0028 0.0146
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0077 0.024 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0088 0.0407
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0058 0.0266
Brugia malayi steroid hormone receptor 0.0041 0.0088 0.0407
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0349 0.1356 0.6249
Leishmania major phosphoglycerate kinase C, glycosomal 0.0345 0.134 0.3618
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0035 0.0196
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0056 0.0149 0.0149
Giardia lamblia Phosphoglycerate kinase 0.0345 0.134 1
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Echinococcus multilocularis alkaline phosphatase 0.0162 0.0586 0.0586
Echinococcus granulosus heat shock protein 0.0033 0.0056 0.0056
Plasmodium vivax NLI interacting factor-like phosphatase, putative 0.0025 0.0023 0.011
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0026 0.0028 0.0028
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0017 0.008
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Brugia malayi jmjC domain containing protein 0.0075 0.023 0.106
Loa Loa (eye worm) hypothetical protein 0.0239 0.0902 0.112
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0083 0.0103
Echinococcus granulosus mixed lineage leukemia protein mll 0.0044 0.0101 0.0101
Loa Loa (eye worm) hypothetical protein 0.0054 0.0144 0.0179
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0073 0.0221 0.0221
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0126 0.0126
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0009 0.0044
Trichomonas vaginalis chaperonin, putative 0.0023 0.0017 0.0063
Brugia malayi Ceramide kinase 0.0077 0.0238 0.1096
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0023
Brugia malayi RNA, U transporter 1 0.0083 0.026 0.12
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0077 0.0238 0.0238
Toxoplasma gondii phosphoglycerate kinase PGKI 0.0345 0.134 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.0144 0.0179
Schistosoma mansoni DNA helicase recq1 0.0028 0.0035 0.0035
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0162 0.0586 0.0586
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0059 0.0059
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0068 0.0201 0.0201
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0014 0.0043
Chlamydia trachomatis phosphoglycerate kinase 0.0345 0.134 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Echinococcus multilocularis microtubule associated protein 2 0.1386 0.5618 0.5618
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0009 0.0001
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0162 0.0586 0.0586
Brugia malayi T-complex protein 1, beta subunit 0.0023 0.0017 0.008
Trichomonas vaginalis hypothetical protein 0.0021 0.0007 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Trypanosoma brucei DNA damage repair protein, putative 0.0039 0.0082 0.02
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.0153
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Brugia malayi beta-lactamase family protein 0.0073 0.0221 0.102
Entamoeba histolytica diacylglycerol kinase, putative 0.0077 0.0238 0.0285
Entamoeba histolytica hypothetical protein 0.0073 0.0221 0.0263
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0035 0.0035
Trypanosoma cruzi DNA damage repair protein, putative 0.0039 0.0082 0.0222
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.0357 0.0433
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.011 0.0375 0.0375
Entamoeba histolytica acyl-CoA synthetase, putative 0.0073 0.022 0.0262
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0039 0.0082 0.0553
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0221 0.0264
Schistosoma mansoni diacylglycerol kinase theta 0.0077 0.0238 0.0238
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0041
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0039 0.0163
Trypanosoma cruzi ISWI complex protein 0.0031 0.0049 0.0131
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0068 0.0201 0.0201
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0009 0.004
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0041 0.0088 0.0407
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.0357 0.2617
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0077 0.0238 0.0295
Plasmodium falciparum DNA repair protein REV1, putative 0.0039 0.0082 0.0589
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.0153
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Leishmania major hypothetical protein, conserved 0.0031 0.0049 0.0108
Trichomonas vaginalis esterase, putative 0.0073 0.0221 0.1005
Brugia malayi mbt repeat family protein 0.005 0.0126 0.0581
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0077 0.024 0.0648
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0039 0.0227
Mycobacterium ulcerans hypothetical protein 0.0073 0.0221 0.0264
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0041 0.0088 0.0407
Trichomonas vaginalis bmru protein, putative 0.0077 0.0238 0.1081
Onchocerca volvulus 0.0073 0.0221 0.2445
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.0154 0.0154
Echinococcus granulosus sphingosine kinase 1 0.1978 0.805 0.805
Schistosoma mansoni apoferritin-2 0.0026 0.0028 0.0028
Echinococcus granulosus Diacylglycerol kinase zeta 0.0077 0.0238 0.0238
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0129 0.0451 0.1201
Echinococcus multilocularis neuropeptide s receptor 0.0917 0.3689 0.3689
Trichomonas vaginalis bromodomain-containing protein, putative 0.0046 0.0112 0.05
Toxoplasma gondii heat shock protein HSP90 0.0033 0.0056 0.0352
Loa Loa (eye worm) hypothetical protein 0.0073 0.022 0.0273
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0357 0.1632
Schistosoma mansoni bromodomain containing protein 0.0142 0.0503 0.0503
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Echinococcus granulosus zinc finger protein 0.0053 0.0139 0.0139
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0221 0.0264
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0157 0.0567 0.1535
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0044 0.0101 0.0101
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0129 0.0451 0.1221
Trypanosoma cruzi Heat shock protein 83, putative 0.0033 0.0056 0.0149
Schistosoma mansoni ap endonuclease 0.0077 0.024 0.024
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0106 0.0106
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0134 0.0471 0.0575
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0023 0.0091
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0039 0.0227
Loa Loa (eye worm) glutaminase 0.0547 0.2169 0.2695
Trypanosoma brucei DNA polymerase IV, putative 0.018 0.0662 0.1776
Trichomonas vaginalis phosphoglycerate kinase, putative 0.0345 0.134 0.6169
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0021 0.0009 0.0022
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0009 0.0044
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Loa Loa (eye worm) MH2 domain-containing protein 0.0246 0.0934 0.1161
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0054 0.0057
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0014 0.0043
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0009 0.0009
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.014 0.0496 0.1323
Mycobacterium ulcerans beta-lactamase 0.0073 0.0221 0.0264
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0916 0.3688 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.011 0.0375 0.0375
Schistosoma mansoni apoferritin-2 0.0026 0.0028 0.0028
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0357 0.0967
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0054 0.0145 0.0145
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0077 0.0238 0.0238
Schistosoma mansoni ferritin light chain 0.0026 0.0028 0.0028
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0046 0.0112 0.0774
Loa Loa (eye worm) hypothetical protein 0.0081 0.0253 0.0314
Trypanosoma cruzi DNA polymerase kappa, putative 0.018 0.0662 0.1794
Echinococcus multilocularis snurportin 1 0.031 0.1194 0.1194
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0041 0.0088 0.0088
Brugia malayi hypothetical protein 0.0021 0.0009 0.0044
Trypanosoma brucei hypothetical protein, conserved 0.0077 0.0238 0.0622
Plasmodium vivax heat shock protein 86, putative 0.0033 0.0056 0.0352
Brugia malayi MH2 domain containing protein 0.0246 0.0934 0.4307
Echinococcus granulosus Diacylglycerol kinase theta 0.0077 0.0238 0.0238
Echinococcus multilocularis expressed protein 0.0033 0.0058 0.0058
Toxoplasma gondii diacylglycerol kinase, putative 0.0077 0.0238 0.172
Mycobacterium ulcerans lipase LipD 0.0073 0.0221 0.0264
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0221 0.0264
Loa Loa (eye worm) diacylglycerol kinase 2 0.0077 0.0238 0.0295
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0044 0.0101 0.0101
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.022 0.0262
Trypanosoma cruzi Sphingosine kinase 0.0077 0.0238 0.0643
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.031 0.1194 0.1484
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0126 0.0126
Trypanosoma brucei unspecified product 0.0087 0.0279 0.0735
Plasmodium vivax acyl-CoA synthetase, putative 0.0054 0.0144 0.1017
Schistosoma mansoni heat shock protein 0.0033 0.0056 0.0056
Brugia malayi Bromodomain containing protein 0.0081 0.0255 0.1174
Mycobacterium tuberculosis Diacylglycerol kinase 0.0077 0.0238 0.0285
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0357 0.1632
Onchocerca volvulus 0.0172 0.0629 0.6949
Brugia malayi nuclear receptor RXR 0.0021 0.0009 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0058 0.025
Echinococcus multilocularis chaperonin containing TCP1, subunit 2 (beta) 0.0023 0.0017 0.0017
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0023 0.0091
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0134 0.0471 0.0471
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0009 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0101 0.0334 0.0885
Leishmania major hypothetical protein, conserved 0.0073 0.0221 0.0578
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0039 0.0163
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.0345 0.134 0.1655
Schistosoma mansoni phosphoglycerate kinase 0.0345 0.134 0.134
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0018 0.0066
Trypanosoma cruzi heat shock protein 90, putative 0.0026 0.0028 0.0075
Trypanosoma cruzi heat shock protein 85, putative 0.0026 0.0028 0.0075
Brugia malayi Pre-SET motif family protein 0.0211 0.0787 0.363
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0026 0.0028 0.0104
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0041 0.0088 0.0407
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0221 0.1005
Schistosoma mansoni sphingoid long chain base kinase 0.1978 0.805 0.805
Brugia malayi latrophilin 2 splice variant baaae 0.0239 0.0902 0.4157
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0088 0.0088
Entamoeba histolytica hypothetical protein 0.0073 0.0221 0.0263
Mycobacterium ulcerans bacterioferritin BfrA 0.0026 0.0028 0.0024
Leishmania major sphingosine kinase A, B, putative 0.0077 0.0238 0.0622
Brugia malayi hypothetical protein 0.0021 0.0009 0.0044
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0018 0.0047
Echinococcus multilocularis ceramide kinase 0.0077 0.0238 0.0238
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0127 0.0442 0.1197
Brugia malayi hypothetical protein 0.0073 0.0221 0.1017
Onchocerca volvulus 0.0081 0.0253 0.2796
Plasmodium vivax SET domain protein, putative 0.0033 0.0059 0.0375
Schistosoma mansoni terminal deoxycytidyl transferase 0.0126 0.0441 0.0441
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0009 0.0009
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.0154 0.0711
Giardia lamblia Heat shock protein HSP 90-alpha 0.0026 0.0028 0.0145
Brugia malayi exodeoxyribonuclease III family protein 0.0077 0.024 0.1104
Trypanosoma brucei unspecified product 0.0087 0.0279 0.0735
Trypanosoma cruzi Sphingosine kinase 0.0077 0.0238 0.0643
Schistosoma mansoni hypothetical protein 0.011 0.0375 0.0375
Echinococcus multilocularis neuropeptide receptor A26 0.0917 0.3689 0.3689
Entamoeba histolytica T-complex protein 1 beta subunit, putative 0.0023 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0203 0.0755 0.0937
Trypanosoma brucei heat shock protein, putative 0.0033 0.0056 0.0127
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0014 0.0016
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.018 0.0662 0.3041
Brugia malayi 6-phosphofructokinase 0.0106 0.0357 0.1646
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.0086
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0162 0.0586 0.0586
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0106 0.0132
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0009 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0041 0.0088 0.0407
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0041 0.0088 0.011
Treponema pallidum phosphoglycerate kinase 0.0345 0.134 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.0357 0.0444
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0127 0.0442 0.1197
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0077 0.0238 0.0643
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0221 0.1005
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0035 0.0235
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0349 0.1356 0.1684
Mycobacterium ulcerans acyl-CoA synthetase 0.0073 0.022 0.0262
Schistosoma mansoni ferritin 0.0026 0.0028 0.0028
Trypanosoma brucei DNA polymerase IV, putative 0.018 0.0662 0.1776
Loa Loa (eye worm) endoplasmin 0.0033 0.0056 0.0069
Loa Loa (eye worm) hypothetical protein 0.0029 0.004 0.005
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0127 0.0442 0.1197
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0056 0.0149
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.0154 0.0154
Leishmania major DNA polymerase eta, putative 0.0116 0.0396 0.1053
Giardia lamblia TCP-1 chaperonin subunit beta 0.0023 0.0017 0.0063
Loa Loa (eye worm) hypothetical protein 0.0022 0.0011 0.0014
Onchocerca volvulus 0.0073 0.0221 0.2445
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0088 0.0088
Brugia malayi Eye-specific diacylglycerol kinase 0.0077 0.0238 0.1096
Echinococcus multilocularis thyroid hormone receptor alpha 0.0041 0.0088 0.0088
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0073 0.022 0.0273
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.0357 0.1632
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0021 0.0009 0.0009
Loa Loa (eye worm) hypothetical protein 0.011 0.0375 0.0466
Leishmania major importin beta-1 subunit, putative 0.0024 0.0018 0.0025
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0059 0.0164 0.1197
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0126 0.0126
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0046 0.0112 0.05
Entamoeba histolytica acyl-coA synthetase, putative 0.0073 0.022 0.0262
Brugia malayi nuclear hormone receptor 0.0041 0.0088 0.0407
Leishmania major T-complex protein 1, beta subunit, putative 0.0023 0.0017 0.0023
Echinococcus multilocularis heat shock protein 0.0033 0.0056 0.0056
Echinococcus multilocularis expressed protein 0.0026 0.0028 0.0028
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0221 0.0264
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0018 0.0066
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0039 0.0081 0.036
Echinococcus multilocularis cpg binding protein 0.0186 0.0685 0.0685
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0073 0.022 0.0262
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0044 0.0101 0.0101
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.004 0.0238
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0466 0.1839 0.2275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0041 0.0088 0.011
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0077 0.0238 0.1081
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0044 0.0101 0.0101
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0077 0.024 0.0287
Onchocerca volvulus Huntingtin homolog 0.0123 0.0428 0.4729
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0051 0.0132 0.0153
Trypanosoma cruzi DNA polymerase kappa, putative 0.018 0.0662 0.1794
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0035 0.0063 0.0063
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0026 0.0027 0.0027
Brugia malayi polk-prov protein 0.0093 0.0304 0.1401
Echinococcus multilocularis dna polymerase kappa 0.018 0.0662 0.0662
Brugia malayi Bloom's syndrome protein homolog 0.0067 0.0197 0.0909
Echinococcus granulosus microtubule associated protein 2 0.1386 0.5618 0.5618
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0221 0.1005
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0059 0.0059
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0082 0.02
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0026 0.0028 0.0148
Echinococcus granulosus snurportin 1 0.031 0.1194 0.1194
Mycobacterium leprae Probable lipase LipE 0.0073 0.0221 0.1596
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0069 0.0163
Loa Loa (eye worm) hypothetical protein 0.0073 0.022 0.0273
Trichomonas vaginalis dullard protein, putative 0.0025 0.0023 0.0091
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.0357 0.0433
Schistosoma mansoni acetyl-CoA synthetase 0.0021 0.0009 0.0009
Brugia malayi Carboxy-terminal domain RNA polymerase II polypeptide A smallphosphatase 1 0.0025 0.0023 0.0108
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0009 0.0011
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0035 0.0162
Onchocerca volvulus 0.0033 0.0059 0.0648
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0041 0.0088 0.0088
Trypanosoma cruzi ISWI complex protein 0.0031 0.0049 0.0131
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0134 0.0471 0.0586
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0009 0.0011
Echinococcus granulosus heat shock protein 90 0.0026 0.0028 0.0028
Trypanosoma brucei chrX additional, unordered contigs 0.0039 0.0082 0.02
Loa Loa (eye worm) hypothetical protein 0.0054 0.0144 0.0179
Echinococcus multilocularis ecdysone induced protein 78C 0.0041 0.0088 0.0088
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0253 0.0253
Trypanosoma cruzi diacylglycerol kinase, putative 0.0077 0.0238 0.0643
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0014 0.0081
Brugia malayi F/Y-rich N-terminus family protein 0.0058 0.0158 0.0727
Trypanosoma brucei DNA damage repair protein, putative 0.0039 0.0082 0.02
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0021 0.0009 0.0011
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0054 0.0144 0.0979
Schistosoma mansoni ap endonuclease 0.0077 0.024 0.024
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.0357 0.2586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0041 0.0088 0.011
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0077 0.0238 0.0238
Trichomonas vaginalis DNA helicase recq1, putative 0.0067 0.0197 0.0894
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0073 0.022 0.0262
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0221 0.1596
Echinococcus granulosus Carboxy terminal domain RNA polymerase II 0.0025 0.0023 0.0023
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0041 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0039 0.0227
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0039 0.0227
Mycobacterium ulcerans hypothetical protein 0.0483 0.1905 0.2358
Trypanosoma brucei DNA polymerase eta, putative 0.0203 0.0755 0.2027
Brugia malayi Phosphoglycerate kinase 0.0345 0.134 0.6176
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0088 0.0088
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0077 0.0238 0.0643
Toxoplasma gondii heat shock protein 90, putative 0.0033 0.0056 0.0352
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.0357 0.0357
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0077 0.024 0.0648
Loa Loa (eye worm) hypothetical protein 0.0123 0.0428 0.0532
Echinococcus multilocularis phosphoglycerate kinase 1 0.0345 0.134 0.134
Trypanosoma brucei phosphoglycerate kinase 0.0345 0.134 0.3618
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0035 0.0044
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0012
Schistosoma mansoni ran 0.0021 0.0009 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Trypanosoma cruzi T-complex protein 1, beta subunit, putative 0.0023 0.0017 0.0045
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Entamoeba histolytica NLI interacting factor-like phosphatase domain-containing protein 0.0025 0.0023 0.0018
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0036 0.0069 0.0163
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0053 0.0137 0.0966
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0039 0.0185
Loa Loa (eye worm) hypothetical protein 0.0057 0.0154 0.0192
Onchocerca volvulus 0.0073 0.0221 0.2445
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0011
Treponema pallidum exodeoxyribonuclease (exoA) 0.0077 0.024 0.1699
Trichomonas vaginalis heat shock protein, putative 0.0026 0.0028 0.0114
Schistosoma mansoni hypothetical protein 0.0179 0.0658 0.0658
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.0522 0.0522
Trichomonas vaginalis glutaminase, putative 0.0547 0.2169 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0106
Brugia malayi beta-lactamase 0.0073 0.0221 0.102
Mycobacterium tuberculosis Conserved protein 0.0073 0.0221 0.0264
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0009 0.0001
Mycobacterium ulcerans hypothetical protein 0.1978 0.805 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0041 0.0088 0.011
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0127 0.0442 0.1197
Echinococcus granulosus ferritin 0.0026 0.0028 0.0028
Echinococcus granulosus alkaline phosphatase 0.0162 0.0586 0.0586
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0041 0.0088 0.011
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.0345 0.134 1
Schistosoma mansoni ran 0.0021 0.0009 0.0009
Plasmodium falciparum diacylglycerol kinase, putative 0.0077 0.0238 0.1752
Brugia malayi AMP-binding enzyme family protein 0.0021 0.0009 0.004
Loa Loa (eye worm) hypothetical protein 0.0073 0.0221 0.0275
Trypanosoma brucei DNA polymerase kappa, putative 0.014 0.0496 0.1323
Trichomonas vaginalis DNA helicase recq, putative 0.0036 0.0069 0.03
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.011 0.0375 0.0375
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0054 0.0145 0.0145
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0039 0.0185
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0077 0.024 0.1733
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.0357 0.0947
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0134 0.0471 0.1277
Loa Loa (eye worm) hypothetical protein 0.0086 0.0275 0.0342
Trichomonas vaginalis diacylglycerol kinase, putative 0.0077 0.0238 0.1081
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0039 0.0081 0.036
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0174 0.0174
Echinococcus multilocularis sphingosine kinase 1 0.1978 0.805 0.805
Entamoeba histolytica heat shock protein 90, putative 0.0033 0.0056 0.0058
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0017 0.0017
Trypanosoma brucei unspecified product 0.0167 0.0607 0.1627
Echinococcus multilocularis bloom syndrome protein 0.0067 0.0197 0.0197
Echinococcus multilocularis zinc finger protein 0.0053 0.0139 0.0139
Plasmodium falciparum T-complex protein 1 subunit beta 0.0023 0.0017 0.0102
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0081 0.036
Brugia malayi AMP-binding enzyme family protein 0.0073 0.022 0.1012
Toxoplasma gondii exonuclease III APE 0.0077 0.024 0.1734
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0073 0.022 0.1584
Brugia malayi AMP-binding enzyme family protein 0.0073 0.022 0.1012
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Trypanosoma brucei DNA polymerase kappa, putative 0.0093 0.0304 0.0802
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0041 0.0088 0.0976
Trichomonas vaginalis ap endonuclease, putative 0.0077 0.024 0.109
Loa Loa (eye worm) latrophilin receptor protein 2 0.011 0.0375 0.0466
Schistosoma mansoni hypothetical protein 0.2452 1 1
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0078 0.0518
Echinococcus multilocularis geminin 0.0179 0.0658 0.0658
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0058 0.0072
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0077 0.024 0.0627
Echinococcus granulosus importin subunit beta 1 0.0029 0.004 0.004
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0221 0.1005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0009 0.0023
Trypanosoma brucei Mitochondrial import inner membrane translocase subunit TIM50 0.0025 0.0023 0.004
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0041 0.0088 0.0088
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0126 0.0126
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0221 0.0221
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0221 0.0264
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Echinococcus granulosus neuropeptide receptor A26 0.0917 0.3689 0.3689
Leishmania major heat shock protein 83-1 0.0033 0.0056 0.0127
Brugia malayi Calcitonin receptor-like protein seb-1 0.0349 0.1356 0.6249
Trypanosoma cruzi heat shock protein 85, putative 0.0033 0.0056 0.0149
Loa Loa (eye worm) hypothetical protein 0.0021 0.0009 0.0012
Schistosoma mansoni DNA helicase recq5 0.0028 0.0035 0.0035
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0134 0.0473 0.0473
Echinococcus multilocularis heat shock protein 90 0.0033 0.0056 0.0056
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.004 0.0086
Leishmania major 4-coumarate:coa ligase-like protein 0.0073 0.022 0.0573
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0021 0.0009 0.004
Entamoeba histolytica hypothetical protein 0.0023 0.0014 0.0007
Echinococcus multilocularis transcription factor Dp 1 0.0077 0.024 0.024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0088 0.0407
Schistosoma mansoni thyroid hormone receptor 0.0041 0.0088 0.0088
Echinococcus granulosus ceramide kinase 0.0077 0.0238 0.0238
Loa Loa (eye worm) hypothetical protein 0.0093 0.0304 0.0378
Trichomonas vaginalis nuclear lim interactor-interacting factor, putative 0.0025 0.0023 0.0091
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0813 0.3261 0.3261
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0126 0.0441 0.0441
Leishmania major hypothetical protein, conserved 0.0025 0.0023 0.004
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0126 0.0441 0.0547
Trypanosoma brucei DNA polymerase kappa, putative 0.018 0.0662 0.1776
Loa Loa (eye worm) oxidoreductase 0.0021 0.0009 0.0011
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0041 0.0088 0.011
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0041 0.0088 0.0407
Loa Loa (eye worm) hypothetical protein 0.0041 0.0088 0.011
Brugia malayi AMP-binding enzyme family protein 0.0073 0.022 0.1012
Plasmodium falciparum NLI interacting factor-like phosphatase, putative 0.0025 0.0023 0.0148
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0106 0.0106
Trichomonas vaginalis diacylglycerol kinase, putative 0.0077 0.0238 0.1081
Loa Loa (eye worm) hypothetical protein 0.0025 0.0023 0.0029
Giardia lamblia Nuclear LIM interactor-interacting factor 1 0.0025 0.0023 0.0109
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.0357 0.0357
Entamoeba histolytica diacylglycerol kinase, putative 0.0077 0.0238 0.0285
Schistosoma mansoni chaperonin containing t-complex protein 1 beta subunit tcpb 0.0023 0.0017 0.0017
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0077 0.024 0.024

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 161 uM Inhibition of recombinant human MAO-A assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182
IC50 (binding) = 201 uM Inhibition of recombinant human MAO-B assessed as inhibition of kynuramine conversion to fluorescent metabolite 4-hydroxyquinoline after 20 mins by fluorescence spectrophotometry ChEMBL. 24012182

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.