Detailed information for compound 1823569

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 448.493 | Formula: C20H24N4O6S
  • H donors: 2 H acceptors: 7 LogP: 0.92 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C([C@@H](n1cnc(c1)S(=O)(=O)C1CC1)CC1CCOCC1)Nc1ccc(cn1)C(=O)O
  • InChi: 1S/C20H24N4O6S/c25-19(23-17-4-1-14(10-21-17)20(26)27)16(9-13-5-7-30-8-6-13)24-11-18(22-12-24)31(28,29)15-2-3-15/h1,4,10-13,15-16H,2-3,5-9H2,(H,26,27)(H,21,23,25)/t16-/m0/s1
  • InChiKey: KAGKVRONFJTRGB-INIZCTEOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucokinase (hexokinase 4) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma mansoni hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania mexicana hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium falciparum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium parvum hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Toxoplasma gondii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase type 2 Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania donovani hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania major hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium yoelii hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Schistosoma japonicum ko:K00844 hexokinase [EC2.7.1.1], putative Get druggable targets OG5_126743 All targets in OG5_126743
Onchocerca volvulus Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi Hexokinase family protein Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium knowlesi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 2 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans similar to D.occidentalis hexokinase HXK which is able to phosphorylate glucose and fructose Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma congolense hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Babesia bovis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Theileria parva hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Treponema pallidum hexokinase (hxk) Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei gambiense hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Neospora caninum cDNA FLJ57348, highly similar to Homo sapiens hexokinase domain containing 1 (HKDC1), mRNA, related Get druggable targets OG5_126743 All targets in OG5_126743
Entamoeba histolytica hexokinase 1 Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Brugia malayi hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Cryptosporidium hominis hexokinase i Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania braziliensis hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Leishmania infantum hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium berghei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Candida albicans one of four closely related hexokinase-like genes similar to P.angusta GLK1 and to S. cerevisiae Glucokinase GLK1 (YCL040W) Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus granulosus hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma cruzi hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Loa Loa (eye worm) hexokinase type II Get druggable targets OG5_126743 All targets in OG5_126743
Trypanosoma brucei hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
Plasmodium vivax hexokinase, putative Get druggable targets OG5_126743 All targets in OG5_126743
Echinococcus multilocularis hexokinase Get druggable targets OG5_126743 All targets in OG5_126743
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi Hexokinase family protein glucokinase (hexokinase 4) 465 aa 470 aa 30.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major hexokinase, putative 0.0096 0.1343 0.7611
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0295 0.0344
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0049 0.005
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0297 0.1705
Trypanosoma cruzi hexokinase, putative 0.0096 0.1343 0.7611
Echinococcus multilocularis peroxidasin 0.0026 0.0297 0.0289
Echinococcus granulosus tyrosine protein kinase shark 0.0007 0.0009 0.0002
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Echinococcus granulosus protein jagged 1 0.0008 0.0037 0.0029
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0189 0.0417
Brugia malayi Hexokinase family protein 0.006 0.081 0.0961
Loa Loa (eye worm) hypothetical protein 0.0013 0.0103 0.0114
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.005
Schistosoma mansoni cytochrome P450 0.0007 0.0016 0.001
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0259 0.0602
Toxoplasma gondii EGF family domain-containing protein 0.0008 0.0037 0.0053
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0664 0.3722
Loa Loa (eye worm) hypothetical protein 0.0027 0.0307 0.0358
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0007 0.0016 0.0079
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0017 0.0171 0.0163
Schistosoma mansoni nuclear receptor 0.0008 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Echinococcus granulosus protein jagged 2 0.0008 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0008
Echinococcus multilocularis thyroid hormone receptor alpha 0.0017 0.0171 0.0163
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.001 0.0061 0.0055
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0017 0.0171 0.0165
Schistosoma mansoni notch 0.0008 0.0038 0.0032
Brugia malayi photoreceptor-specific nuclear receptor 0.0017 0.0171 0.0196
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0017 0.0171 0.0963
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0007 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0332 0.0389
Onchocerca volvulus 0.0008 0.0037 0.0171
Echinococcus multilocularis hexokinase 0.0096 0.1343 0.1336
Echinococcus granulosus neurogenic locus notch protein 4 0.0008 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0012 0.0095 0.0105
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0171 0.0196
Echinococcus multilocularis microtubule associated protein 2 0.0678 1 1
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0014 0.0016
Toxoplasma gondii microneme protein, putative 0.0019 0.0189 0.0417
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0307 0.0358
Schistosoma mansoni nuclear receptor 0.0008 0.0034 0.0028
Echinococcus granulosus peroxidasin 0.0026 0.0297 0.0289
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0017 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.005
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0259 0.1233
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Echinococcus granulosus lamin dm0 0.0027 0.0307 0.0299
Brugia malayi GCC2 and GCC3 family protein 0.0008 0.0037 0.0035
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0014 0.0124 0.0118
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Loa Loa (eye worm) steroid hormone receptor 0.0017 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0031 0.0367 0.0431
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Brugia malayi orphan nuclear receptor NR2E1 0.0008 0.0034 0.0032
Toxoplasma gondii PAN domain-containing protein 0.0289 0.4213 1
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0034 0.0027
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0095 0.1321 0.1315
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.001 0.0061 0.0054
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0171 0.0196
Onchocerca volvulus 0.0026 0.0297 0.1705
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0259 0.1233
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0014 0.0071
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0009 0.0049 0.0041
Echinococcus multilocularis hexokinase 0.0096 0.1343 0.1336
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0017 0.0171 0.0163
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0061 0.0054
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0008 0.0034 0.0027
Echinococcus granulosus epidermal growth factor receptor 0.0294 0.4288 0.4284
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0007 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Schistosoma mansoni steroid hormone receptor ad4bp 0.0017 0.0171 0.0165
Onchocerca volvulus Putative cubilin 0.0008 0.0037 0.0171
Mycobacterium leprae putative cytochrome p450 0.0007 0.0016 0.0009
Schistosoma mansoni peroxidasin 0.0026 0.0297 0.0291
Brugia malayi steroid hormone receptor 0.0017 0.0171 0.0196
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0664 0.0657
Schistosoma mansoni lamin 0.0027 0.0307 0.0301
Mycobacterium leprae Conserved hypothetical protein 0.0007 0.0016 0.0009
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0664 0.1513
Echinococcus multilocularis ecdysone induced protein 78C 0.0017 0.0171 0.0163
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0037 0.0035
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0259 0.1233
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.176 0.1754
Onchocerca volvulus Hexokinase homolog 0.006 0.081 0.4731
Schistosoma mansoni tyrosine kinase 0.0095 0.1321 0.1316
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0123 0.0138
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0007 0.0014 0.0007
Echinococcus multilocularis lamin dm0 0.0027 0.0307 0.0299
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0017 0.0171 0.0165
Echinococcus multilocularis tyrosine protein kinase shark 0.0007 0.0009 0.0002
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0664 0.3722
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0007 0.0016 0.0009
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0034 0.0032
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0664 0.1572
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0664 0.0657
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Brugia malayi Peroxidasin 0.0026 0.0297 0.0346
Brugia malayi Nuclear hormone receptor-like 1 0.0009 0.0049 0.005
Toxoplasma gondii PAN/Apple domain-containing protein 0.0019 0.0189 0.0417
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0007 0.0014 0.0007
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0124 0.176 1
Schistosoma mansoni hypothetical protein 0.0167 0.2389 0.2385
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0016 0.001
Onchocerca volvulus 0.0019 0.0189 0.1071
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.0034 0.0158
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Brugia malayi cytochrome P450 0.0007 0.0016 0.001
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0171 0.0857
Loa Loa (eye worm) CYP4Cod1 0.0007 0.0016 0.001
Brugia malayi Nuclear hormone receptor E75 0.0008 0.0034 0.0032
Echinococcus granulosus insulin receptor 0.0095 0.1321 0.1315
Onchocerca volvulus 0.0007 0.0014 0.0039
Onchocerca volvulus 0.0007 0.0014 0.0039
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0103 0.0095
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0017 0.0171 0.0196
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0014 0.0071
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0189 0.0417
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.176 0.1754
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0007 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Trypanosoma brucei hexokinase, putative 0.0096 0.1343 0.7611
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.001 0.0061 0.0054
Echinococcus multilocularis notch 0.0008 0.0037 0.0029
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0037 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0017 0.0171 0.0196
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0007 0.0016 0.0079
Entamoeba histolytica hypothetical protein 0.0035 0.0438 0.1031
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0061 0.0054
Echinococcus granulosus tyrosine protein kinase Src64B 0.001 0.0061 0.0054
Schistosoma mansoni notch 0.0008 0.0037 0.003
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0123 0.0115
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0171 0.0165
Plasmodium vivax hexokinase, putative 0.0096 0.1343 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.001 0.0061 0.0054
Schistosoma mansoni nck2/grb4 0.0007 0.0021 0.0015
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1999 1
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0171 0.0163
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0014 0.0071
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0989 0.0982
Brugia malayi nuclear receptor NHR-88 0.0017 0.0171 0.0196
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0259 0.0301
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0007 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0061 0.0054
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0007 0.0021 0.0016
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0007 0.0016 0.0079
Brugia malayi hypothetical protein 0.0009 0.0049 0.005
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0007 0.0016 0.0079
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0017 0.0171 0.0165
Loa Loa (eye worm) TK/INSR protein kinase 0.0095 0.1321 0.1573
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0007 0.0016 0.0079
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.5892 0.5888
Brugia malayi hexokinase type II 0.0031 0.0367 0.0431
Loa Loa (eye worm) hypothetical protein 0.012 0.1703 0.2031
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0014 0.0071
Echinococcus multilocularis tyrosine protein kinase Fyn 0.001 0.0061 0.0054
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0014 0.0071
Onchocerca volvulus 0.0027 0.0307 0.1763
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Echinococcus granulosus growth factor receptor bound protein 2 0.0007 0.0021 0.0014
Schistosoma mansoni tyrosine kinase 0.001 0.0061 0.0055
Echinococcus granulosus protein jagged 1 0.0008 0.0037 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0017 0.0171 0.0196
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0008 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Schistosoma mansoni hypothetical protein 0.0007 0.0016 0.001
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0008 0.0034 0.0028
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Echinococcus multilocularis hexokinase type 2 0.0096 0.1343 0.1336
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0259 0.0301
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0664 0.3722
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0189 0.0218
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0664 0.3722
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0095 0.1321 0.1315
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0171 0.5
Echinococcus multilocularis FTZ F1 alpha 0.0017 0.0171 0.0163
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0016 0.001
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0017 0.0009
Echinococcus multilocularis cpg binding protein 0.003 0.0356 0.0349
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0009
Echinococcus granulosus Nuclear hormone receptor HR96 0.0008 0.0034 0.0027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Schistosoma mansoni tyrosine kinase 0.0006 0.0008 0.0001
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0021 0.0015
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0009 0.0049 0.0041
Echinococcus granulosus delta-like protein 1 0.0008 0.0037 0.0029
Echinococcus granulosus thyroid hormone receptor alpha 0.0008 0.0034 0.0027
Loa Loa (eye worm) DR-78 0.0008 0.0034 0.0032
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0103 0.0095
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0664 0.0657
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0037 0.0029
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0007 0.0014 0.0016
Brugia malayi Protein kinase domain containing protein 0.0015 0.0136 0.0154
Brugia malayi Protein kinase domain containing protein 0.0095 0.1321 0.1573
Schistosoma mansoni tyrosine kinase 0.001 0.0061 0.0055
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0008 0.0034 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Onchocerca volvulus Protein ultraspiracle homolog 0.0017 0.0171 0.0963
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0007 0.0016 0.001
Trypanosoma brucei cytochrome P450, putative 0.0007 0.0016 0.001
Onchocerca volvulus 0.0019 0.0189 0.1071
Schistosoma mansoni notch 0.0008 0.0037 0.003
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Onchocerca volvulus 0.0026 0.0297 0.1705
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0017 0.0171 0.0196
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) hypothetical protein 0.0023 0.0259 0.0301
Echinococcus granulosus tyrosine protein kinase Lyn 0.0011 0.0075 0.0067
Echinococcus granulosus NCK adaptor protein 0.0007 0.0021 0.0014
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0007 0.0016 0.0009
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0259 0.1295
Brugia malayi Cytochrome P450 family protein 0.0007 0.0016 0.001
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.001 0.0061 0.0054
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Entamoeba histolytica hexokinase 1 0.0096 0.1343 0.3197
Brugia malayi ecdysone receptor 0.0008 0.0034 0.0032
Schistosoma mansoni tyrosine kinase 0.0159 0.2271 0.2266
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0014 0.0008
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0297 0.0346
Toxoplasma gondii microneme protein MIC17A 0.0019 0.0189 0.0417
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Schistosoma mansoni notch 0.0008 0.0037 0.003
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0008 0.0034 0.0158
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0307 0.0358
Schistosoma mansoni cpg binding protein 0.003 0.0356 0.035
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0123 0.0115
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0008 0.0034 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0007 0.0016 0.0079
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4185 1
Brugia malayi intermediate filament protein 0.0027 0.0307 0.0358
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0041 0.004
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0159 0.2271 0.2265
Onchocerca volvulus Peroxidase homolog 0.0026 0.0297 0.1705
Echinococcus granulosus epidermal growth factor receptor 0.0159 0.2271 0.2265
Loa Loa (eye worm) hypothetical protein 0.0023 0.0259 0.0301
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Plasmodium falciparum hexokinase 0.0096 0.1343 1
Brugia malayi ecdysteroid receptor 0.0017 0.0171 0.0196
Schistosoma mansoni tyrosine kinase 0.0095 0.1321 0.1316
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Trypanosoma brucei protein kinase, putative 0.0051 0.0664 0.3722
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0014 0.0008
Toxoplasma gondii hexokinase 0.0096 0.1343 0.3164
Echinococcus multilocularis nuclear receptor nhr 48 0.0008 0.0034 0.0027
Echinococcus granulosus slit 2 protein 0.0008 0.0037 0.0029
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0014 0.0071
Brugia malayi Furin-like cysteine rich region family protein 0.0294 0.4288 0.5127
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0189 0.0417
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0297 0.0346
Onchocerca volvulus 0.0028 0.0332 0.1914
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0017 0.0171 0.0163
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0007 0.0016 0.001
Onchocerca volvulus 0.0096 0.1343 0.7875
Echinococcus granulosus hexokinase 0.0096 0.1343 0.1336
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0019 0.0189 0.0417
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0297 0.0346
Loa Loa (eye worm) hexokinase 0.003 0.0355 0.0416
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0007 0.0016 0.0009
Onchocerca volvulus 0.0023 0.0259 0.1482
Leishmania major hexokinase, putative 0.0096 0.1343 0.7611
Brugia malayi nuclear receptor NHR-67 0.0008 0.0034 0.0032
Echinococcus granulosus nuclear receptor nhr 48 0.0008 0.0034 0.0027
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.4185 1
Brugia malayi Cytochrome P450 family protein 0.0007 0.0016 0.001
Onchocerca volvulus 0.0008 0.0037 0.0171
Echinococcus granulosus fibropellin Ia 0.0008 0.0037 0.0029
Brugia malayi Delta serrate ligand family protein 0.0008 0.0037 0.0035
Brugia malayi MAP kinase sur-1 0.0051 0.0664 0.0786
Echinococcus multilocularis mitogen activated protein kinase 11 0.0124 0.176 0.1754
Schistosoma mansoni cpg binding protein 0.003 0.0356 0.035
Echinococcus granulosus mitogen activated protein kinase 11 0.0124 0.176 0.1754
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0014 0.0016
Echinococcus granulosus cytochrome P450 2K1 0.0007 0.0016 0.0008
Echinococcus multilocularis tyrosine protein kinase Abl 0.001 0.0061 0.0054
Toxoplasma gondii microneme protein MIC17B 0.0019 0.0189 0.0417
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0259 0.1233
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Onchocerca volvulus Huntingtin homolog 0.012 0.1703 1
Echinococcus granulosus ecdysone induced protein 78C 0.0017 0.0171 0.0163
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0438 0.0432
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0438 0.0431
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0014 0.0071
Echinococcus granulosus tyrosine protein kinase Src42A 0.001 0.0061 0.0054
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0008 0.0037 0.0035
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0007 0.0016 0.0009
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0034 0.0028
Loa Loa (eye worm) hypothetical protein 0.012 0.1703 0.2031
Loa Loa (eye worm) oxidoreductase 0.0007 0.0014 0.0008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Toxoplasma gondii microneme protein MIC4 0.0019 0.0189 0.0417
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Schistosoma mansoni retinoic acid receptor RXR 0.0017 0.0171 0.0165
Brugia malayi small heat shock protein 0.0568 0.8356 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0008 0.0034 0.0032
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0061 0.0054
Brugia malayi Uncoordinated protein 44 0.0014 0.0123 0.0138
Schistosoma mansoni laminin gamma-3 chain 0.0008 0.0037 0.003
Brugia malayi conserved hypotetical protein 0.0008 0.0034 0.0032
Schistosoma mansoni tyrosine kinase 0.0159 0.2271 0.2266
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0297 0.0346
Trypanosoma brucei hexokinase 0.0096 0.1343 0.7611
Toxoplasma gondii hypothetical protein 0.0019 0.0189 0.0417
Onchocerca volvulus 0.0008 0.0037 0.0171
Schistosoma mansoni hexokinase 0.0096 0.1343 0.1337
Echinococcus granulosus lamin 0.0027 0.0307 0.0299
Echinococcus granulosus neurogenic locus protein delta 0.0008 0.0037 0.0029
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0017 0.0171 0.0163
Schistosoma mansoni hypothetical protein 0.0035 0.0438 0.0432
Echinococcus granulosus intermediate filament protein 0.0027 0.0307 0.0299
Brugia malayi Hexokinase family protein 0.003 0.0355 0.0416
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Brugia malayi hypothetical protein 0.0026 0.0297 0.0346
Onchocerca volvulus 0.0096 0.1343 0.7875
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.176 1
Brugia malayi hypothetical protein 0.0009 0.0049 0.005
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0007 0.0016 0.0079
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0124 0.176 0.2099
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Onchocerca volvulus Bile acid receptor homolog 0.0017 0.0171 0.0963
Schistosoma mansoni tyrosine kinase 0.0007 0.0009 0.0003
Onchocerca volvulus Slit protein homolog 0.0008 0.0037 0.0171
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.001 0.0061 0.0054
Echinococcus multilocularis epidermal growth factor receptor 0.0294 0.4288 0.4284
Echinococcus multilocularis neural cadherin 0.0008 0.0037 0.0029
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0297 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0017 0.0171 0.0196
Echinococcus multilocularis tyrosine protein kinase Src42A 0.001 0.0061 0.0054
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0017 0.0171 0.0165
Schistosoma mansoni thyroid hormone receptor 0.0017 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Brugia malayi SRC-1 0.001 0.0061 0.0064
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0259 0.1233
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0014 0.0071
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Leishmania major cytochrome p450-like protein 0.0007 0.0016 0.001
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0297 0.1705
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0259 0.0602
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0017 0.0171 0.0163
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0014 0.0071
Brugia malayi Muscle positioning protein 4 0.0008 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Brugia malayi nuclear receptor RXR 0.0009 0.0049 0.005
Loa Loa (eye worm) hypothetical protein 0.0066 0.0888 0.1055
Schistosoma mansoni tyrosine kinase 0.0294 0.4288 0.4285
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hexokinase type II 0.0096 0.1343 0.1599
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0438 0.0431
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0123 0.0138
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0017 0.0171 0.0163
Onchocerca volvulus 0.0007 0.0014 0.0039
Toxoplasma gondii cytochrome p450 superfamily protein 0.0007 0.0016 0.0004
Brugia malayi Tyrosine-protein kinase abl-1 0.001 0.0061 0.0064
Echinococcus multilocularis fat cadherin tumor suppressor 0.0008 0.0037 0.0029
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0124 0.176 1
Onchocerca volvulus 0.0019 0.0189 0.1071
Entamoeba histolytica hypothetical protein 0.0035 0.0438 0.1031
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0035
Brugia malayi Sex muscle abnormal protein 5 0.0007 0.0021 0.0016
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0007 0.0016 0.0009
Loa Loa (eye worm) hexokinase 0.0096 0.1343 0.1599
Leishmania major cytochrome p450-like protein 0.0007 0.0016 0.001
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0037 0.0029
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0989 0.0982
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0017 0.0171 0.0163
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0008 0.0034 0.0028
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0017 0.0171 0.0196
Schistosoma mansoni tyrosine kinase 0.001 0.0061 0.0055
Brugia malayi nuclear hormone receptor family member odr-7 0.0008 0.0034 0.0032
Schistosoma mansoni tyrosine kinase 0.0156 0.223 0.2226
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Schistosoma mansoni growth factor receptor-bound protein 0.0007 0.0021 0.0015
Echinococcus multilocularis mitogen activated protein kinase 14 0.0124 0.176 0.1754
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0171 0.1183
Echinococcus granulosus neural cadherin 0.0008 0.0037 0.0029
Echinococcus multilocularis growth factor receptor bound protein 2 0.0007 0.0021 0.0014
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0007 0.0016 0.0009
Brugia malayi hypothetical protein 0.0035 0.0438 0.0516
Brugia malayi P38 map kinase family protein 2 0.0124 0.176 0.2099
Echinococcus multilocularis tyrosine protein kinase Src64B 0.001 0.0061 0.0054
Echinococcus multilocularis geminin 0.0167 0.2389 0.2384
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0007 0.0016 0.0079
Echinococcus multilocularis neurogenic locus notch protein 0.0008 0.0037 0.0029
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0014 0.0071
Onchocerca volvulus Peroxidase homolog 0.0026 0.0297 0.1705
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Toxoplasma gondii hypothetical protein 0.0019 0.0189 0.0417
Toxoplasma gondii microneme protein MIC17C 0.0019 0.0189 0.0417
Brugia malayi Nuclear hormone receptor-like 1 0.0017 0.0171 0.0196
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0157 0.0786
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0259 0.1233
Loa Loa (eye worm) cytochrome P450 0.0007 0.0016 0.001
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Echinococcus granulosus death domain containing protein 0.0014 0.0123 0.0115
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0034 0.0027
Brugia malayi Cadherin domain containing protein 0.0008 0.0037 0.0035
Onchocerca volvulus 0.0019 0.0189 0.1071
Echinococcus multilocularis fibropellin Ia 0.0008 0.0037 0.0029
Brugia malayi tailless protein 0.0008 0.0034 0.0032
Echinococcus multilocularis protein jagged 1 0.0008 0.0037 0.0029
Toxoplasma gondii PAN domain-containing protein 0.0289 0.4213 1
Onchocerca volvulus 0.0008 0.0037 0.0171
Echinococcus multilocularis neurogenic locus notch protein 4 0.0008 0.0037 0.0029
Entamoeba histolytica hypothetical protein 0.0035 0.0438 0.1031
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0297 0.0346
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0259 0.1233
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1999 1
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0259 0.1295
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0664 0.0786
Schistosoma mansoni tyrosine kinase 0.0156 0.223 0.2226
Schistosoma mansoni netrin receptor unc5 0.0014 0.0123 0.0116
Echinococcus multilocularis 0.0091 0.1262 0.1255
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0017 0.0171 0.0196
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0123 0.0678
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0008 0.0034 0.0027
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0014 0.0008
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Echinococcus granulosus c src tyrosine kinase 0.001 0.0061 0.0054
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0014 0.0008
Echinococcus granulosus hexokinase 0.0096 0.1343 0.1336
Toxoplasma gondii histone lysine methyltransferase SET1 0.0053 0.0708 0.1652
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0171 0.0163
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.4185 1
Onchocerca volvulus 0.0019 0.0189 0.1071
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0017 0.0171 0.0196
Brugia malayi Cytochrome P450 family protein 0.0026 0.0295 0.0344
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0568 0.8356 1
Schistosoma mansoni hypothetical protein 0.0014 0.0123 0.0116
Loa Loa (eye worm) nuclear receptor NHR-67 0.0008 0.0034 0.0032
Trypanosoma cruzi hexokinase, putative 0.0096 0.1343 0.7611
Onchocerca volvulus Huntingtin homolog 0.012 0.1703 1
Entamoeba histolytica hexokinase 2 0.0096 0.1343 0.3197
Schistosoma mansoni peroxidasin 0.0026 0.0297 0.0291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0017 0.0171 0.0163
Echinococcus granulosus Ankyrin 0.0014 0.0124 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0017 0.0171 0.0196
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Echinococcus multilocularis slit 2 protein 0.0008 0.0037 0.0029
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0007 0.0016 0.0009
Onchocerca volvulus 0.0019 0.0189 0.1071
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0007 0.0016 0.0009
Echinococcus multilocularis musashi 0.0027 0.0307 0.0299
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0664 0.3722
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0259 0.0301
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0124 0.0139
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0171 0.0792
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0008 0.0034 0.0027
Brugia malayi nuclear receptor NHR-88 0.0008 0.0034 0.0032
Onchocerca volvulus 0.0096 0.1343 0.7875
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0007 0.0016 0.0079
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) SRC-1 0.001 0.0061 0.0064
Echinococcus granulosus hexokinase 0.0096 0.1343 0.1336
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0124 0.0139
Echinococcus multilocularis hexokinase 0.0096 0.1343 0.1336
Brugia malayi Cytochrome P450 family protein 0.0007 0.0016 0.001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0017 0.0171 0.0163
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0171 0.0196
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0123 0.0115
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0017 0.0171 0.0163
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0259 0.1402
Toxoplasma gondii subtilisin SUB12 0.0019 0.0189 0.0417
Schistosoma mansoni cell polarity protein 0.0008 0.0037 0.003
Loa Loa (eye worm) hexokinase 0.006 0.081 0.0961
Loa Loa (eye worm) hexokinase 0.0096 0.1343 0.1599
Onchocerca volvulus 0.0019 0.0189 0.1071
Onchocerca volvulus 0.0008 0.0034 0.0158
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0664 0.0657
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0014 0.0008
Trypanosoma brucei hexokinase 0.0096 0.1343 0.7611
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0007 0.0016 0.0009
Echinococcus granulosus geminin 0.0167 0.2389 0.2384
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1999 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0803 0.0797
Onchocerca volvulus 0.0026 0.0297 0.1705
Brugia malayi Death domain containing protein 0.0014 0.0123 0.0138
Schistosoma mansoni intermediate filament proteins 0.0027 0.0307 0.0301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Echinococcus multilocularis c src tyrosine kinase 0.001 0.0061 0.0054
Loa Loa (eye worm) hypothetical protein 0.0031 0.0367 0.0431
Schistosoma mansoni septate junction protein 0.0008 0.0037 0.003
Brugia malayi nuclear hormone receptor 0.0008 0.0034 0.0032
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Onchocerca volvulus 0.0008 0.0037 0.0171
Brugia malayi CXXC zinc finger family protein 0.0028 0.0332 0.0389
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0007 0.0016 0.0079
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0259 0.1233
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0171 0.1183
Loa Loa (eye worm) cytochrome P450 family protein 0.0007 0.0016 0.001
Brugia malayi notch-like transmembrane receptor 0.0008 0.0037 0.0035
Schistosoma mansoni lamin 0.0027 0.0307 0.0301
Echinococcus multilocularis 0.0007 0.0016 0.0008
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0664 0.1572
Onchocerca volvulus 0.0017 0.0171 0.0963
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0007 0.0016 0.0009
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Schistosoma mansoni nuclear hormone receptor 0.0017 0.0171 0.0165
Loa Loa (eye worm) nuclear hormone receptor 0.0008 0.0034 0.0032
Brugia malayi hypothetical protein 0.012 0.1703 0.2031
Echinococcus granulosus hexokinase type 2 0.0096 0.1343 0.1336
Echinococcus granulosus mitogen activated protein kinase 14 0.0124 0.176 0.1754
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0124 0.176 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0017 0.0171 0.0196
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0017 0.0009
Loa Loa (eye worm) hypothetical protein 0.0023 0.0259 0.0301
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0042 0.0035
Loa Loa (eye worm) hypothetical protein 0.0014 0.0124 0.014
Echinococcus multilocularis protein jagged 1 0.0008 0.0037 0.0029
Schistosoma mansoni hypothetical protein 0.0167 0.2389 0.2385
Onchocerca volvulus 0.006 0.081 0.4731
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Onchocerca volvulus 0.0019 0.0189 0.1071
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Toxoplasma gondii PAN domain-containing protein 0.0019 0.0189 0.0417
Schistosoma mansoni hypothetical protein 0.0008 0.0037 0.003
Schistosoma mansoni notch 0.0008 0.0037 0.003
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0259 0.1402
Brugia malayi nuclear hormone receptor 0.0017 0.0171 0.0196
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0017 0.0171 0.0165
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0007 0.0016 0.0079
Mycobacterium ulcerans hypothetical protein 0.0023 0.0259 0.1233
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0157 0.0786
Echinococcus granulosus tyrosine protein kinase Fyn 0.001 0.0061 0.0054
Brugia malayi Hexokinase family protein 0.0096 0.1343 0.1599
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0014 0.0071
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0014 0.0008
Echinococcus multilocularis lamin 0.0027 0.0307 0.0299
Schistosoma mansoni notch 0.0008 0.0037 0.003
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0007 0.0016 0.0079
Loa Loa (eye worm) hypothetical protein 0.0007 0.0014 0.0008
Loa Loa (eye worm) Notch2 0.0008 0.0037 0.0035
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0664 0.3722
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.005
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0007 0.0021 0.0016
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0664 0.1572
Onchocerca volvulus 0.0007 0.0014 0.0039
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0014 0.0008
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0123 0.0116
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0007 0.0016 0.0009
Loa Loa (eye worm) TK/EGFR protein kinase 0.0294 0.4288 0.5127
Brugia malayi nuclear receptor RXR 0.0008 0.0034 0.0032
Echinococcus multilocularis epidermal growth factor receptor 0.0159 0.2271 0.2265
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0297 0.0346
Brugia malayi nuclear hormone receptor family member nhr-6 0.0008 0.0034 0.0032
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0017 0.0171 0.0163
Echinococcus granulosus FTZ F1 alpha 0.0017 0.0171 0.0163
Onchocerca volvulus 0.0008 0.0034 0.0158
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0014 0.0123 0.0138
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0297 0.1705
Onchocerca volvulus Neurogenic locus notch homolog 0.0008 0.0038 0.0181
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0008 0.0037 0.0171
Echinococcus multilocularis insulin receptor 0.0095 0.1321 0.1315
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0007 0.0016 0.0079
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0123 0.0115
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0007 0.0016 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0017 0.0171 0.0196
Trypanosoma cruzi cytochrome P450, putative 0.0007 0.0016 0.001
Brugia malayi Blistered cuticle protein 3 0.0026 0.0297 0.0346
Brugia malayi Calcium binding EGF domain containing protein 0.0008 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0026 0.0297 0.0346
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0007 0.0016 0.0009
Echinococcus granulosus protein jagged 2 0.0008 0.0037 0.0029
Brugia malayi hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0017 0.0171 0.0196
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0017 0.0171 0.0196
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0259 0.1402
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0157 0.0786
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0259 0.0602
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0009 0.0049 0.0043
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0017 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0019 0.0189 0.0218
Schistosoma mansoni coup transcription factor 0.0017 0.0171 0.0165
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0297 0.0346
Loa Loa (eye worm) hypothetical protein 0.0026 0.0299 0.035
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4185 1
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0664 0.0658
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0007 0.0016 0.001
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0307 0.0358
Schistosoma mansoni slit 0.0008 0.0037 0.003
Onchocerca volvulus 0.0019 0.0189 0.1071
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0189 0.0218
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.001 0.0061 0.0054
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Loa Loa (eye worm) notch protein 0.0008 0.0037 0.0035
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0664 0.1572
Leishmania major cytochrome p450-like protein 0.0007 0.0016 0.001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0017 0.0171 0.0196
Echinococcus multilocularis Ankyrin 0.0014 0.0124 0.0117
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0007 0.0016 0.0009
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0009 0.0049 0.0043
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0297 0.0346
Schistosoma mansoni microtubule-associated protein tau 0.0678 1 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0017 0.0171 0.0196
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0007 0.0021 0.0015
Brugia malayi EGF-like domain containing protein 0.0008 0.0037 0.0035
Onchocerca volvulus 0.0019 0.0189 0.1071
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0007 0.0016 0.0009
Schistosoma mansoni adapter molecule crk 0.0007 0.0021 0.0015
Schistosoma mansoni tyrosine kinase 0.0156 0.223 0.2226
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0008 0.0034 0.0027
Loa Loa (eye worm) hypothetical protein 0.0008 0.0034 0.0032
Echinococcus granulosus notch 0.0008 0.0037 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0009 0.0049 0.005
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0017 0.0171 0.0196
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0664 0.3722
Echinococcus multilocularis protein jagged 2 0.0008 0.0037 0.0029
Echinococcus granulosus dnaJ subfamily B 0.0402 0.5892 0.5888
Echinococcus multilocularis NCK adaptor protein 0.0007 0.0021 0.0014
Brugia malayi Variant SH3 domain containing protein 0.0007 0.0021 0.0016
Echinococcus granulosus tyrosine protein kinase Btk29A 0.001 0.0061 0.0054
Brugia malayi PAN domain containing protein 0.0019 0.0189 0.0218
Schistosoma mansoni tyrosine kinase 0.001 0.0061 0.0055
Schistosoma mansoni nuclear receptor nhr-48 0.0008 0.0034 0.0028
Schistosoma mansoni cpg binding protein 0.0028 0.0332 0.0326
Loa Loa (eye worm) hypothetical protein 0.0012 0.0095 0.0105
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0297 0.1705
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0007 0.0016 0.0079
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0007 0.0016 0.0079
Schistosoma mansoni RAR-like nuclear receptor 0.0017 0.0171 0.0165
Onchocerca volvulus 0.0027 0.0307 0.1763
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0259 0.1233
Onchocerca volvulus 0.0019 0.0189 0.1071
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Brugia malayi Cadherin domain containing protein 0.0008 0.0037 0.0035
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0007 0.0016 0.0079
Schistosoma mansoni nuclear hormone receptor 0.0008 0.0034 0.0028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0017 0.0171 0.0196
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0297 0.0346
Echinococcus granulosus neurogenic locus notch protein 0.0008 0.0037 0.0029
Loa Loa (eye worm) hypothetical protein 0.0009 0.0049 0.005
Schistosoma mansoni hypothetical protein 0.0402 0.5892 0.5889
Schistosoma mansoni zinc finger protein 0.0008 0.0034 0.0028
Brugia malayi hexokinase 0.0096 0.1343 0.1599
Brugia malayi Steroid receptor seven-up type 2 0.0017 0.0171 0.0196
Entamoeba histolytica hypothetical protein 0.0035 0.0438 0.1031
Loa Loa (eye worm) hypothetical protein 0.0008 0.0037 0.0035
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0007 0.0016 0.0079
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0157 0.0786
Brugia malayi hypothetical protein 0.0008 0.0034 0.0032
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0017 0.001
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0007 0.0016 0.0079
Echinococcus granulosus cpg binding protein 0.003 0.0356 0.0349
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.001 0.0061 0.0054
Echinococcus multilocularis neurogenic locus protein delta 0.0008 0.0037 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4185 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0664 0.1548
Loa Loa (eye worm) PAN domain-containing protein 0.0019 0.0189 0.0218

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 1350 nM Activation of recombinant human glucokinase by G6PDH/NADP coupled assay ChEMBL. 24239482
FC (binding) = 0.11 Activation of recombinant human glucokinase assessed as decrease in enzyme Km for glucose by G6PDH/NADP coupled assay relative to control ChEMBL. 24239482
FC (binding) = 1.21 Activation of recombinant human glucokinase assessed as increase in enzyme Vmax for glucose by G6PDH/NADP coupled assay relative to control ChEMBL. 24239482

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.