Detailed information for compound 1899187

Basic information

Technical information
  • TDR Targets ID: 1899187
  • Name: (4R)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxobuta noyl]amino]-5-[[(2S,3S)-1-[[(2S)-1-[(2S,4R)-2 -[[(2R)-1-hydroxy-1-oxopentan-2-yl]carbamoyl] -4-(phenylmethoxy)pyrrolidin-1-yl]-3-methyl-1 -oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2- yl]amino]-5-oxopentanoic acid
  • MW: 818.91 | Formula: C39H58N6O13
  • H donors: 8 H acceptors: 12 LogP: 1.42 Rotable bonds: 30
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCC[C@H](C(=O)O)NC(=O)[C@@H]1C[C@H](CN1C(=O)[C@H](C(C)C)NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@H](NC(=O)[C@@H](NC(=O)C)CC(=O)O)CCC(=O)O)OCc1ccccc1
  • InChi: 1S/C39H58N6O13/c1-7-12-27(39(56)57)42-36(53)29-17-25(58-20-24-13-10-9-11-14-24)19-45(29)38(55)32(21(3)4)43-37(54)33(22(5)8-2)44-34(51)26(15-16-30(47)48)41-35(52)28(18-31(49)50)40-23(6)46/h9-11,13-14,21-22,25-29,32-33H,7-8,12,15-20H2,1-6H3,(H,40,46)(H,41,52)(H,42,53)(H,43,54)(H,44,51)(H,47,48)(H,49,50)(H,56,57)/t22-,25+,26+,27+,28-,29-,32-,33-/m0/s1
  • InChiKey: AUECKNIWQAGLTA-NKVGBWMYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (4R)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-[[(1S,2S)-1-[[(1S)-1-[(2S,4R)-2-[[(1R)-1-carboxybutyl]carbamoyl]-4-(phenylmethoxy)pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamoyl]-2-methyl-butyl]amino]-5-oxo-pentanoic acid
  • (4R)-4-[[(2S)-2-acetamido-4-hydroxy-1,4-dioxobutyl]amino]-5-[[(1S,2S)-1-[[[(1S)-1-[[(2S,4R)-2-[[[(1R)-1-carboxybutyl]amino]-oxomethyl]-4-(phenylmethoxy)-1-pyrrolidinyl]-oxomethyl]-2-methylpropyl]amino]-oxomethyl]-2-methylbutyl]amino]-5-oxopentanoic acid
  • (4R)-4-[[(2S)-2-acetamido-4-hydroxy-4-keto-butanoyl]amino]-5-[[(1S,2S)-1-[[(1S)-1-[(2S,4R)-4-(benzyloxy)-2-[[(1R)-1-carboxybutyl]carbamoyl]pyrrolidine-1-carbonyl]-2-methyl-propyl]carbamoyl]-2-methyl-butyl]amino]-5-keto-valeric acid
  • (4R)-4-[[(2S)-2-acetamido-4-hydroxy-4-oxo-butanoyl]amino]-5-[[(2S,3S)-1-[[(2S)-1-[(2S,4R)-2-[[(2R)-1-hydroxy-1-oxo-pentan-2-yl]carbamoyl]-4-(phenylmethoxy)pyrrolidin-1-yl]-3-methyl-1-oxo-butan-2-yl]amino]-3-methyl-1-oxo-pentan-2-yl]amino]-5-oxo-pentanoic acid
  • Azapeptide-based compound 23

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis importin subunit beta 1 0.0019 0.0024 0.0024
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0107 0.0454 0.1397
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0053 0.0191 0.0739
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0053 0.0191 0.0191
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0071 0.0279 0.0279
Trypanosoma brucei beta tubulin 0.0471 0.2216 1
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0025 0.0088
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0019 0.0028 0.0085
Brugia malayi Smad1 0.0032 0.0091 0.0324
Trypanosoma brucei Diacylglycerol kinase catalytic domain containing protein, putative 0.0027 0.0063 0.0284
Plasmodium vivax tubulin epsilon chain, putative 0.0255 0.117 0.5281
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0097 0.0343
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0124 0.0124
Schistosoma mansoni rab6-interacting 0.0039 0.0124 0.0124
Echinococcus granulosus Tubulin beta 2C chain 0.0471 0.2216 0.2216
Loa Loa (eye worm) hypothetical protein 0.0107 0.0454 0.1397
Toxoplasma gondii exonuclease III APE 0.0019 0.0025 0.0111
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0107 0.0453 0.1753
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus multilocularis mothers against decapentaplegic 6 0.0015 0.0004 0.0004
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0019 0.0028 0.0085
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0127 0.0493
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0245 0.1123 0.4347
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0245 0.1123 0.3459
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0194
Loa Loa (eye worm) tubulin alpha chain 0.0356 0.166 0.5113
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0034 0.0097 0.0097
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0097 0.0097
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0024 0.0109
Echinococcus multilocularis mothers against decapentaplegic 2 0.0015 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0071 0.0279 0.0991
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0454 0.0454
Mycobacterium ulcerans glutaminase 0.0547 0.2584 0.7958
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0159 0.0566
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0053 0.0191 0.0862
Echinococcus multilocularis tubulin subunit TubB 0.0356 0.166 0.166
Loa Loa (eye worm) hypothetical protein 0.0122 0.0526 0.1619
Trypanosoma brucei cAMP-specific phosphodiesterase, putative 0.0053 0.0191 0.0862
Plasmodium falciparum ABC transporter G family member 2 0.0019 0.0028 0.0125
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0077 0.0348
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0107 0.0453 0.2044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0537 0.1653
Trypanosoma brucei tubulin delta chain 0.0111 0.0471 0.2124
Schistosoma mansoni hypothetical protein 0.0812 0.3869 0.3869
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0116 0.0413
Schistosoma mansoni tar DNA-binding protein 0.0189 0.085 0.085
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0159 0.0566
Loa Loa (eye worm) hypothetical protein 0.0073 0.0286 0.0881
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0127 0.0575
Mycobacterium ulcerans lipase LipD 0.0107 0.0454 0.1397
Brugia malayi hypothetical protein 0.0039 0.0124 0.0441
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Loa Loa (eye worm) calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase 0.0053 0.0191 0.0588
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0024 0.0075
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0093 0.0286
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0454 0.1756
Brugia malayi hypothetical protein 0.0027 0.0063 0.0223
Echinococcus multilocularis RUN 0.0039 0.0124 0.0124
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0024 0.0075
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0024 0.0109
Echinococcus granulosus lamin 0.0055 0.0199 0.0199
Schistosoma mansoni tubulin subunit delta 0.0111 0.0471 0.0471
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0024 0.0109
Trypanosoma cruzi diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Entamoeba histolytica ABC transporter, putative 0.0019 0.0028 0.0085
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0247 0.0247
Mycobacterium tuberculosis Conserved protein 0.0683 0.3247 0.9975
Schistosoma mansoni smad1 5 8 and 0.0032 0.0091 0.0091
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0024 0.0094
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Loa Loa (eye worm) nuclear factor I 0.0018 0.0021 0.0064
Echinococcus multilocularis beta tubulin 0.0471 0.2216 0.2216
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0004 0.0015
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0014 0 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0014 0 0.0002
Echinococcus granulosus tubulin gamma 1 chain 0.0255 0.117 0.117
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.027 0.1243 0.4811
Trypanosoma cruzi zeta tubulin, putative 0.0111 0.0471 0.2124
Mycobacterium ulcerans putative regulatory protein 0.002 0.0029 0.0089
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0186 0.0837 0.0837
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0077 0.0298
Schistosoma mansoni hypothetical protein 0.0047 0.0163 0.0163
Echinococcus granulosus Tubulin beta 2C chain 0.0471 0.2216 0.2216
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0144 0.0633 0.2452
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0053 0.0191 0.0191
Trichomonas vaginalis tubulin gamma chain, putative 0.0111 0.0471 0.1822
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0174 0.0535
Echinococcus granulosus tubulin alpha 1C chain 0.0356 0.166 0.166
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0006 0.0006
Schistosoma mansoni tubulin subunit alpha 0.0356 0.166 0.166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0073 0.0286 0.0286
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0174 0.0617
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0122 0.0526 0.0526
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.027 0.1243 0.3829
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0196 0.0758
Brugia malayi Steroid receptor seven-up type 2 0.0071 0.0279 0.0991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0031 0.0118
Echinococcus granulosus Smad4 0.0032 0.0091 0.0091
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0111
Echinococcus granulosus mothers against decapentaplegic 2 0.0015 0.0004 0.0004
Plasmodium falciparum diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Brugia malayi Tubulin alpha chain 0.0356 0.166 0.5901
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0111 0.0471 0.2124
Echinococcus multilocularis lipoxygenase domain containing protein 0.0039 0.0124 0.0124
Echinococcus multilocularis Tubulin beta 2C chain 0.0471 0.2216 0.2216
Loa Loa (eye worm) glutaminase 0.0547 0.2584 0.7958
Leishmania major hypothetical protein, conserved 0.0027 0.0063 0.0284
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0077 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0088 0.0395
Plasmodium vivax cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Schistosoma mansoni survival motor neuron protein 0.0047 0.0163 0.0163
Trypanosoma brucei Sphingosine kinase 0.0027 0.0063 0.0284
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0102 0.0314
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0537 0.1653
Echinococcus multilocularis Tubulin alpha 1 chain 0.0356 0.166 0.166
Schistosoma mansoni hypothetical protein 0.0145 0.0636 0.0636
Trichomonas vaginalis tubulin alpha chain, putative 0.0471 0.2216 0.8577
Echinococcus multilocularis Tubulin beta 2C chain 0.0471 0.2216 0.2216
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Entamoeba histolytica tubulin gamma chain 0.0255 0.117 0.3605
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0191 0.0739
Brugia malayi Protein kinase domain containing protein 0.0122 0.0526 0.1868
Mycobacterium leprae cell division protein FtsZ 0.0111 0.0471 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0024 0.0024
Brugia malayi nuclear receptor RXR 0.0038 0.0116 0.0413
Echinococcus multilocularis neuropeptide s receptor 0.0457 0.2149 0.2149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0159 0.049
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0077 0.0298
Brugia malayi steroid hormone receptor 0.0071 0.0279 0.0991
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0279 0.0279
Echinococcus granulosus peroxisome assembly protein 26 0.0356 0.166 0.166
Leishmania major beta tubulin 0.0471 0.2216 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0453 0.2044
Toxoplasma gondii beta tubulin 0.0471 0.2216 1
Schistosoma mansoni coup transcription factor 0.0071 0.0279 0.0279
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0279 0.0991
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0471 0.1822
Echinococcus multilocularis GPCR, family 2 0.0145 0.0636 0.0636
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Giardia lamblia hypothetical protein 0.0053 0.0191 0.086
Trypanosoma cruzi epsilon tubulin, putative 0.0255 0.117 0.5281
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1057 0.1057
Brugia malayi latrophilin 2 splice variant baaae 0.0313 0.145 0.5154
Loa Loa (eye worm) hypothetical protein 0.0381 0.1781 0.5487
Trichomonas vaginalis calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0739
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0186 0.0837 0.0837
Plasmodium vivax ABC transporter G family member 2, putative 0.0019 0.0028 0.0125
Echinococcus granulosus eukaryotic initiation factor 4A III 0.003 0.0077 0.0077
Entamoeba histolytica tubulin alpha chain, putative 0.0356 0.166 0.5113
Leishmania major beta tubulin 0.0471 0.2216 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0315
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0097 0.0343
Giardia lamblia Beta tubulin 0.0471 0.2216 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0071 0.0279 0.0279
Brugia malayi Tubulin alpha chain 0.0111 0.0471 0.1673
Schistosoma mansoni hypothetical protein 0.1023 0.4895 0.4895
Mycobacterium tuberculosis Diacylglycerol kinase 0.0027 0.0063 0.0193
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0071 0.0279 0.0279
Echinococcus granulosus beta tubulin 0.0471 0.2216 0.2216
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0014 0 0.0002
Schistosoma mansoni peroxidasin 0.0027 0.0063 0.0063
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0862
Echinococcus multilocularis tar DNA binding protein 0.0189 0.085 0.085
Loa Loa (eye worm) alpha-tubulin 0.0356 0.166 0.5113
Echinococcus multilocularis cpg binding protein 0.0093 0.0385 0.0385
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Mycobacterium ulcerans putative regulatory protein 0.002 0.0029 0.0089
Plasmodium falciparum LCCL domain-containing protein 0.0039 0.0124 0.056
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0088 0.0088
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.025
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0174 0.0174
Onchocerca volvulus 0.0027 0.0063 0.0224
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0053 0.0191 0.0191
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0038 0.0116 0.0357
Brugia malayi Ceramide kinase 0.0027 0.0063 0.0223
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0075
Trypanosoma cruzi tubulin delta chain 0.0111 0.0471 0.2124
Leishmania major DNA polymerase eta, putative 0.0019 0.0024 0.0109
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0071 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Onchocerca volvulus Netrin receptor homolog 0.0122 0.0526 0.1868
Echinococcus granulosus tubulin alpha chain 0.0356 0.166 0.166
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0053 0.0191 0.0191
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Loa Loa (eye worm) tubulin alpha-2 chain 0.0356 0.166 0.5113
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Echinococcus multilocularis Ankyrin 0.0122 0.0526 0.0526
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0026 0.0062 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0196 0.0758
Brugia malayi hypothetical protein 0.0071 0.028 0.0995
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0055 0.025
Schistosoma mansoni tubulin subunit beta 0.0111 0.0471 0.0471
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0071 0.0279 0.0279
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0088 0.0395
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0065 0.0247 0.1115
Leishmania major importin beta-1 subunit, putative 0.0015 0.0007 0.0033
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0127 0.2304
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0024 0.011
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Echinococcus multilocularis ceramide kinase 0.0027 0.0063 0.0063
Entamoeba histolytica protein tyrosine phosphatase, putative 0.027 0.1243 0.3829
Trichomonas vaginalis tubulin beta chain, putative 0.0356 0.166 0.6425
Brugia malayi Peroxidasin 0.0027 0.0063 0.0224
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0025 0.0076
Plasmodium vivax hypothetical protein, conserved 0.002 0.0029 0.0131
Trichomonas vaginalis tubulin, putative 0.0144 0.0633 0.2452
Brugia malayi ABC transporter family protein 0.0016 0.0013 0.0048
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0025 0.0111
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0163 0.0579
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0159 0.3382
Echinococcus multilocularis Smad4 0.0032 0.0091 0.0091
Echinococcus granulosus tubulin beta 4A class IVa 0.0471 0.2216 0.2216
Brugia malayi beta-lactamase family protein 0.0107 0.0454 0.1613
Trypanosoma cruzi tubulin delta chain 0.0111 0.0471 0.2124
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0032 0.0091 0.0091
Onchocerca volvulus 0.027 0.1243 0.4419
Brugia malayi nuclear hormone receptor family member nhr-6 0.0034 0.0097 0.0343
Mycobacterium ulcerans aldehyde dehydrogenase 0.0124 0.0537 0.1653
Toxoplasma gondii hypothetical protein 0.0054 0.0196 0.0884
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus snurportin 1 0.0199 0.09 0.09
Loa Loa (eye worm) TAR-binding protein 0.0189 0.085 0.2617
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.027 0.1243 0.3819
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0025 0.0025
Echinococcus granulosus tubulin alpha 0.0255 0.117 0.117
Schistosoma mansoni diacylglycerol kinase zeta iota 0.0027 0.0063 0.0063
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0063 0.0243
Plasmodium vivax tubulin alpha chain, putative 0.0356 0.166 0.7491
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0255 0.117 0.5281
Loa Loa (eye worm) tubulin beta chain 0.0111 0.0471 0.145
Brugia malayi Tubulin alpha-2 chain 0.0356 0.166 0.5901
Echinococcus granulosus dna polymerase kappa 0.0019 0.0024 0.0024
Echinococcus multilocularis hypothetical protein 0.0356 0.166 0.166
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Onchocerca volvulus 0.0107 0.0454 0.1613
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Trichomonas vaginalis tubulin gamma chain, putative 0.0255 0.117 0.453
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0024 0.0051 0.0051
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0096
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0381 0.1781 0.8038
Brugia malayi glutaminase DH11.1 0.0547 0.2584 0.9185
Brugia malayi beta-lactamase 0.0107 0.0454 0.1613
Schistosoma mansoni smad 0.0032 0.0091 0.0091
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0088 0.0269
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Schistosoma mansoni cpg binding protein 0.0093 0.0385 0.0385
Loa Loa (eye worm) beta-lactamase 0.0107 0.0454 0.1397
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0175
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0063 0.0284
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0102 0.0461
Trypanosoma brucei alpha tubulin 0.0356 0.166 0.7491
Brugia malayi beta-tubulin, identical 0.0471 0.2216 0.7878
Loa Loa (eye worm) Smad1 0.0032 0.0091 0.0281
Schistosoma mansoni tar DNA-binding protein 0.0189 0.085 0.085
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0027 0.0063 0.0284
Schistosoma mansoni hypothetical protein 0.0027 0.0063 0.0063
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0088 0.0311
Schistosoma mansoni hypothetical protein 0.1023 0.4895 0.4895
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.028 0.028
Loa Loa (eye worm) hypothetical protein 0.0457 0.2152 0.6627
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.003 0.0077 0.0237
Entamoeba histolytica hypothetical protein 0.0015 0.0007 0.0022
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0071 0.0279 0.0859
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0071 0.0279 0.0991
Onchocerca volvulus 0.0594 0.2813 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0356 0.166 0.6425
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0051 0.0051
Schistosoma mansoni nuclear receptor nhr-48 0.0034 0.0097 0.0097
Trypanosoma brucei ATP-binding cassette protein, putative 0.0019 0.0028 0.0125
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0025 0.0111
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0088 0.0395
Loa Loa (eye worm) tubulin alpha 2 0.0245 0.1123 0.3459
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0071 0.0279 0.0991
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0034 0.0097 0.0097
Schistosoma mansoni lipoxygenase 0.0164 0.073 0.073
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0097 0.0097
Echinococcus granulosus ATP binding cassette sub family G 0.0019 0.0028 0.0028
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0087 0.0358 0.1615
Entamoeba histolytica hypothetical protein, conserved 0.0683 0.3247 1
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Loa Loa (eye worm) hypothetical protein 0.003 0.0077 0.0237
Schistosoma mansoni smad 0.0015 0.0004 0.0004
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0071 0.0279 0.0279
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0053 0.0191 0.0191
Schistosoma mansoni microtubule-associated protein tau 0.2076 1 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0356 0.166 0.166
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0176 0.0789 0.2803
Brugia malayi Eye-specific diacylglycerol kinase 0.0027 0.0063 0.0223
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0127 0.0575
Loa Loa (eye worm) hypothetical protein 0.0176 0.0789 0.2429
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.003 0.0077 0.0348
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0454 0.2047
Loa Loa (eye worm) hypothetical protein 0.0212 0.096 0.2958
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.003 0.0077 0.0274
Trypanosoma cruzi epsilon tubulin, putative 0.0255 0.117 0.5281
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0127 0.0493
Echinococcus granulosus tubulin alpha 1C chain 0.0356 0.166 0.166
Schistosoma mansoni sphingosine kinase A B 0.0683 0.3247 0.3247
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0071 0.0279 0.0991
Echinococcus granulosus GPCR family 2 0.0145 0.0636 0.0636
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.003 0.0077 0.0077
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0174 0.0174
Loa Loa (eye worm) hypothetical protein 0.0145 0.0636 0.1957
Giardia lamblia DINP protein human, muc B family 0.0019 0.0024 0.0107
Loa Loa (eye worm) hypothetical protein 0.002 0.0029 0.0089
Echinococcus multilocularis Diacylglycerol kinase zeta 0.0027 0.0063 0.0063
Echinococcus granulosus tubulin alpha chain 0.0356 0.166 0.166
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0073 0.0286 0.1017
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Echinococcus granulosus nuclear receptor nhr 48 0.0034 0.0097 0.0097
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0053 0.0191 0.0191
Entamoeba histolytica tubulin alpha-1 chain 0.0356 0.166 0.5113
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0063 0.0194
Mycobacterium ulcerans esterase/lipase LipP 0.0107 0.0454 0.1397
Trypanosoma brucei ABC transporter, putative 0.0019 0.0028 0.0125
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0122 0.0526 0.1619
Echinococcus multilocularis smad 0.0032 0.0091 0.0091
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0189 0.085 0.085
Echinococcus granulosus tubulin alpha chain 0.0356 0.166 0.166
Echinococcus multilocularis nuclear receptor nhr 48 0.0034 0.0097 0.0097
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0381 0.1781 0.1781
Schistosoma mansoni ankyrin 23/unc44 0.0122 0.0526 0.0526
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0031 0.0118
Echinococcus granulosus dnaJ subfamily B 0.0812 0.3869 0.3869
Brugia malayi Tubulin beta chain 0.0144 0.0633 0.2252
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0071 0.0279 0.0859
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0034 0.0097 0.0343
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Mycobacterium ulcerans hypothetical protein 0.0683 0.3247 1
Trypanosoma cruzi cAMP-specific phosphodiesterase, putative 0.0053 0.0191 0.0862
Echinococcus multilocularis netrin receptor unc 5 0.0122 0.0526 0.0526
Mycobacterium tuberculosis Conserved protein 0.0107 0.0454 0.1394
Schistosoma mansoni intermediate filament proteins 0.0055 0.0199 0.0199
Schistosoma mansoni zinc finger protein 0.0034 0.0097 0.0097
Echinococcus granulosus ecdysone induced protein 78C 0.0071 0.0279 0.0279
Brugia malayi RNA recognition motif domain containing protein 0.0189 0.085 0.3021
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus Diacylglycerol kinase theta 0.0027 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0107 0.0454 0.1397
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0328 0.1524 0.1524
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0471 0.2216 0.2216
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0102 0.5
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0111 0.0471 0.1822
Brugia malayi hypothetical protein 0.0038 0.0116 0.0413
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0063 0.0194
Echinococcus multilocularis Tubulin beta 2C chain 0.0471 0.2216 0.2216
Echinococcus multilocularis snurportin 1 0.0199 0.09 0.09
Onchocerca volvulus 0.0034 0.0097 0.0343
Echinococcus granulosus mixed lineage leukemia protein mll 0.0024 0.0051 0.0051
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0034 0.0097 0.0097
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0159 0.0489
Entamoeba histolytica tubulin family protein 0.0471 0.2216 0.6826
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0088 0.027
Schistosoma mansoni tubulin subunit beta 0.0471 0.2216 0.2216
Mycobacterium ulcerans transmembrane ABC transporter ATP-binding protein 0.0019 0.0028 0.0085
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Brugia malayi TAR-binding protein 0.0189 0.085 0.3021
Toxoplasma gondii alpha-tubulin I, putative 0.0356 0.166 0.7491
Loa Loa (eye worm) hypothetical protein 0.0054 0.0194 0.0598
Loa Loa (eye worm) hypothetical protein 0.0232 0.1057 0.3254
Mycobacterium ulcerans cell division protein FtsZ 0.0111 0.0471 0.145
Toxoplasma gondii HEAT repeat-containing protein 0.0019 0.0024 0.011
Echinococcus granulosus ATP binding cassette sub family G 0.0019 0.0028 0.0028
Toxoplasma gondii beta-tubulin, putative 0.0471 0.2216 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0036 0.0107 0.0329
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0025 0.0111
Loa Loa (eye worm) diacylglycerol kinase 2 0.0027 0.0063 0.0194
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0055 0.025
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0015 0.0004 0.0015
Echinococcus granulosus Tubulin alpha 1 chain 0.0356 0.166 0.166
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.0633 0.2452
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0026 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0107 0.0454 0.1397
Brugia malayi MH1 domain containing protein 0.0018 0.0021 0.0074
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0107 0.0454 0.1613
Toxoplasma gondii aldehyde dehydrogenase 0.0124 0.0537 0.2421
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0053 0.0191 0.0739
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0328 0.1524 0.5418
Echinococcus granulosus tar DNA binding protein 0.0189 0.085 0.085
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0027 0.0063 0.0243
Loa Loa (eye worm) BEN-1 protein 0.0471 0.2216 0.6826
Loa Loa (eye worm) histone methyltransferase 0.003 0.0077 0.0237
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0124 0.0537 0.1648
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Schistosoma mansoni thyroid hormone receptor 0.0071 0.0279 0.0279
Leishmania major beta tubulin 0.0471 0.2216 1
Brugia malayi beta-lactamase family protein 0.0107 0.0454 0.1613
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0224
Loa Loa (eye worm) nuclear receptor NHR-67 0.0034 0.0097 0.0297
Mycobacterium tuberculosis Probable lipase LipE 0.0107 0.0454 0.1394
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0038 0.0116 0.0116
Plasmodium falciparum tubulin delta chain, putative 0.0111 0.0471 0.2124
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0196 0.0758
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0073 0.0286 0.1017
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0025 0.0025
Brugia malayi Inositol-1 0.004 0.0127 0.0453
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0071 0.0279 0.0279
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0191 0.0862
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0191 0.0862
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0453 0.2044
Trypanosoma cruzi diacylglycerol kinase-like protein, putative 0.0027 0.0063 0.0284
Trypanosoma cruzi beta tubulin, putative 0.0471 0.2216 1
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0088 0.0088
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0739
Schistosoma mansoni hypothetical protein 0.0122 0.0526 0.0526
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.049
Leishmania major hypothetical protein, conserved 0.0107 0.0454 0.2047
Echinococcus multilocularis lamin 0.0055 0.0199 0.0199
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.002 0.0029 0.0089
Loa Loa (eye worm) ABC transporter 0.0016 0.0013 0.0042
Echinococcus multilocularis eukaryotic initiation factor 4A 0.003 0.0077 0.0077
Plasmodium falciparum alpha tubulin 2 0.0356 0.166 0.7491
Echinococcus multilocularis tubulin alpha 3 chain 0.0356 0.166 0.166
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Brugia malayi CXXC zinc finger family protein 0.0088 0.0361 0.1282
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0024 0.0094
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0088 0.0088
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0186 0.0837 0.0837
Echinococcus granulosus neuropeptide s receptor 0.0457 0.2149 0.2149
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Brugia malayi eukaryotic initiation factor 4A 0.003 0.0077 0.0274
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Brugia malayi hypothetical protein 0.0016 0.0012 0.0044
Trichomonas vaginalis tubulin, putative 0.0111 0.0471 0.1822
Onchocerca volvulus 0.0047 0.0163 0.0579
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0356 0.166 0.166
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0034 0.0097 0.0297
Echinococcus multilocularis Tubulin beta 2C chain 0.0471 0.2216 0.2216
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0024 0.0074
Giardia lamblia Gamma tubulin 0.0255 0.117 0.528
Echinococcus granulosus Tubulin beta 2C chain 0.0471 0.2216 0.2216
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0093 0.0286
Echinococcus multilocularis high affinity cgmp specific 3' 5' cyclic 0.0053 0.0191 0.0191
Leishmania major DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0235 0.1073 0.1073
Schistosoma mansoni rab6-interacting 0.0039 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Loa Loa (eye worm) tubulin beta-1 chain 0.0471 0.2216 0.6826
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0315
Trypanosoma brucei zeta tubulin, putative 0.0111 0.0471 0.2124
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0053 0.0191 0.0191
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Trichomonas vaginalis diacylglycerol kinase, putative 0.0027 0.0063 0.0243
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0024 0.0086
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Mycobacterium tuberculosis Probable hydrolase 0.0107 0.0454 0.1394
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.003 0.0077 0.0348
Trypanosoma brucei tubulin gamma chain 0.0255 0.117 0.5281
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0053 0.0191 0.0679
Loa Loa (eye worm) hypothetical protein 0.0039 0.0124 0.0383
Loa Loa (eye worm) eye-specific diacylglycerol kinase 0.0027 0.0063 0.0194
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.0199 0.0707
Loa Loa (eye worm) hypothetical protein 0.0107 0.0454 0.1397
Echinococcus granulosus tubulin subunit TubB 0.0356 0.166 0.166
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0073 0.0286 0.0286
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.0107 0.0453 0.0453
Echinococcus granulosus tubulin delta chain 0.0111 0.0471 0.0471
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0111
Schistosoma mansoni Smad4 0.0032 0.0091 0.0091
Schistosoma mansoni thyroid hormone receptor 0.0071 0.0279 0.0279
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0159 0.049
Loa Loa (eye worm) MH2 domain-containing protein 0.0476 0.2244 0.6911
Entamoeba histolytica Ran family GTPase 0.0014 0 0.0001
Echinococcus multilocularis tubulin alpha chain 0.0356 0.166 0.166
Loa Loa (eye worm) hypothetical protein 0.0245 0.1123 0.3459
Loa Loa (eye worm) hypothetical protein 0.0053 0.0191 0.0588
Echinococcus multilocularis tubulin delta chain 0.0111 0.0471 0.0471
Toxoplasma gondii hypothetical protein 0.002 0.0029 0.0131
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0315
Trypanosoma brucei hypothetical protein, conserved 0.0107 0.0454 0.2047
Plasmodium falciparum tubulin epsilon chain, putative 0.0255 0.117 0.5281
Onchocerca volvulus 0.0027 0.0063 0.0224
Echinococcus multilocularis tubulin alpha chain 0.0356 0.166 0.166
Loa Loa (eye worm) hypothetical protein 0.0025 0.0055 0.0171
Echinococcus multilocularis tubulin alpha 3 chain 0.0356 0.166 0.166
Echinococcus multilocularis tubulin alpha 0.0255 0.117 0.117
Trichomonas vaginalis tubulin gamma chain, putative 0.0255 0.117 0.453
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0063 0.0063
Leishmania major diacylglycerol kinase-like protein 0.0027 0.0063 0.0284
Echinococcus multilocularis FTZ F1 alpha 0.0071 0.0279 0.0279
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0107 0.0453 0.1753
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0191 0.0862
Giardia lamblia ABC transporter 0.0019 0.0027 0.0118
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0063 0.0194
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0191 0.0739
Plasmodium falciparum importin beta, putative 0.0019 0.0024 0.011
Brugia malayi RNA binding protein 0.0189 0.085 0.3021
Schistosoma mansoni hypothetical protein 0.0039 0.0124 0.0124
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0071 0.0279 0.0279
Schistosoma mansoni RAR-like nuclear receptor 0.0071 0.0279 0.0279
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0224
Loa Loa (eye worm) tubulin beta-2A chain 0.0471 0.2216 0.6826
Loa Loa (eye worm) transcription factor SMAD2 0.0476 0.2244 0.6911
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0313 0.145 0.4465
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0025 0.0076
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0025 0.0076
Brugia malayi Uncoordinated protein 44 0.0122 0.0526 0.1868
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0159 0.0718
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0031 0.0118
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.027 0.1243 0.5609
Leishmania major GTP-binding protein, putative 0.0014 0 0.0002
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Echinococcus granulosus Tubulin beta 2C chain 0.0471 0.2216 0.2216
Schistosoma mansoni high-affinity cgmp-specific 35-cyclic phosphodiesterase 0.0053 0.0191 0.0191
Schistosoma mansoni glutaminase 0.0547 0.2584 0.2584
Leishmania major hypothetical protein, conserved 0.0025 0.0055 0.025
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0454 0.1756
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0159 0.049
Brugia malayi cytoplasmic intermediate filament protein 0.0029 0.0076 0.027
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0071 0.0279 0.0279
Brugia malayi hypothetical protein 0.0025 0.0055 0.0197
Brugia malayi nuclear hormone receptor 0.0034 0.0097 0.0343
Loa Loa (eye worm) DR-78 0.0034 0.0097 0.0297
Brugia malayi intermediate filament protein 0.0055 0.0199 0.0707
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0537 0.0537
Brugia malayi Pre-SET motif family protein 0.0065 0.0247 0.0878
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.025
Schistosoma mansoni peroxidasin 0.0027 0.0063 0.0063
Brugia malayi Pre-SET motif family protein 0.0439 0.2062 0.7329
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0019 0.0028 0.0028
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0063 0.0224
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0071 0.0279 0.0279
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0024 0.0051 0.0051
Trypanosoma brucei beta tubulin 0.0471 0.2216 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0107 0.0454 0.1397
Schistosoma mansoni smad1 5 8 and 0.0032 0.0091 0.0091
Plasmodium vivax delta tubulin, putative 0.0111 0.0471 0.2124
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1689 0.8124 0.8124
Brugia malayi nuclear receptor NHR-88 0.0034 0.0097 0.0343
Echinococcus granulosus Ankyrin 0.0122 0.0526 0.0526
Echinococcus granulosus histone lysine methyltransferase setb 0.0065 0.0247 0.0247
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0014 0 0.0001
Plasmodium vivax RNA helicase-1, putative 0.003 0.0077 0.0348
Onchocerca volvulus Peroxidasin homolog 0.0027 0.0063 0.0224
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus granulosus dna polymerase eta 0.0019 0.0024 0.0024
Schistosoma mansoni tubulin subunit gamma 0.0255 0.117 0.117
Trypanosoma brucei epsilon tubulin 0.0255 0.117 0.5281
Loa Loa (eye worm) blistered cuticle protein 3 0.0027 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0357
Leishmania major beta tubulin 0.0471 0.2216 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0127 0.0392
Entamoeba histolytica tubulin family protein 0.0471 0.2216 0.6826
Loa Loa (eye worm) tubulin alpha chain 0.0356 0.166 0.5113
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Brugia malayi hypothetical protein 0.0039 0.0124 0.0441
Schistosoma mansoni tubulin subunit alpha 0.0356 0.166 0.166
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0088 0.0395
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0071 0.0279 0.0859
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.027 0.1243 0.4811
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0053 0.0191 0.0739
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0077 0.0348
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0862
Echinococcus multilocularis tubulin alpha chain 0.0356 0.166 0.166
Giardia lamblia Beta tubulin 0.0471 0.2216 1
Brugia malayi hypothetical protein 0.0594 0.2813 1
Brugia malayi tubulin alpha-2 chain 0.0356 0.166 0.5901
Trichomonas vaginalis sphingosine kinase, putative 0.0027 0.0063 0.0243
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Loa Loa (eye worm) hypothetical protein 0.0356 0.166 0.5113
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Plasmodium falciparum phosphodiesterase gamma, putative 0.0053 0.0191 0.0862
Trypanosoma brucei alpha tubulin 0.0356 0.166 0.7491
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0328 0.1524 0.1524
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0247 0.0247
Leishmania major beta tubulin 0.0471 0.2216 1
Trypanosoma cruzi ABC transporter, putative 0.0019 0.0028 0.0125
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0159 0.0566
Loa Loa (eye worm) hypothetical protein 0.0053 0.0191 0.0588
Leishmania major beta tubulin 0.0471 0.2216 1
Schistosoma mansoni diacylglycerol kinase theta 0.0027 0.0063 0.0063
Trypanosoma cruzi alpha tubulin, putative 0.0356 0.166 0.7491
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0087 0.0358 0.1385
Trichomonas vaginalis glutaminase, putative 0.0547 0.2584 1
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0191 0.0862
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Giardia lamblia Hypothetical protein 0.0053 0.0191 0.086
Leishmania major beta tubulin 0.0471 0.2216 1
Trypanosoma cruzi Sphingosine kinase 0.0027 0.0063 0.0284
Schistosoma mansoni nuclear receptor 0.0034 0.0097 0.0097
Toxoplasma gondii hypothetical protein 0.002 0.0029 0.0131
Trypanosoma brucei alpha tubulin, putative 0.0144 0.0633 0.2858
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0036 0.0107 0.2276
Loa Loa (eye worm) steroid hormone receptor 0.0071 0.0279 0.0859
Leishmania major beta tubulin 0.0471 0.2216 1
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0075 0.0268
Trypanosoma brucei cAMP-specific phosphodiesterase 0.0107 0.0453 0.2044
Onchocerca volvulus 0.0088 0.0361 0.1282
Giardia lamblia Translation initiation factor eIF-4A, putative 0.003 0.0077 0.0346
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0145 0.0636 0.0636
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.003 0.0077 0.0237
Trypanosoma brucei diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Echinococcus granulosus peroxidasin 0.0027 0.0063 0.0063
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0122 0.0526 0.0526
Echinococcus multilocularis tubulin subunit beta 0.0471 0.2216 0.2216
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Brugia malayi Nuclear hormone receptor-like 1 0.0071 0.0279 0.0991
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Mycobacterium ulcerans beta-lactamase 0.0107 0.0454 0.1397
Echinococcus multilocularis Polycystic kidney disease protein 0.0039 0.0124 0.0124
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0097 0.0097
Schistosoma mansoni sphingoid long chain base kinase 0.0683 0.3247 0.3247
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0073 0.0286 0.1108
Loa Loa (eye worm) tubulin gamma chain 0.0255 0.117 0.3605
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0055 0.025
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0145 0.0636 0.0636
Brugia malayi nuclear receptor NHR-88 0.0071 0.0279 0.0991
Loa Loa (eye worm) MH1 domain-containing protein 0.0032 0.0091 0.0281
Giardia lamblia Delta tubulin 0.0111 0.0471 0.2122
Entamoeba histolytica protein tyrosine phosphatase, putative 0.027 0.1243 0.3829
Leishmania major zeta tubulin, putative 0.0111 0.0471 0.2124
Echinococcus granulosus netrin receptor unc 5 0.0122 0.0526 0.0526
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0174 0.0174
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0071 0.0279 0.0859
Plasmodium falciparum cGMP-specific phosphodiesterase 0.0053 0.0191 0.0862
Schistosoma mansoni smad1 5 8 and 0.0032 0.0091 0.0091
Trypanosoma brucei hypothetical protein, conserved 0.0053 0.0191 0.0862
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.003 0.0077 0.0298
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0127 0.0493
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0031 0.0118
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.003 0.0077 0.0348
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.0633 0.2452
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.027 0.1243 0.4419
Plasmodium falciparum phosphodiesterase delta, putative 0.0053 0.0191 0.0862
Schistosoma mansoni cpg binding protein 0.0088 0.0361 0.0361
Plasmodium vivax multidomain scavenger receptor, putative 0.0039 0.0124 0.056
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.027 0.1243 0.4811
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Trypanosoma cruzi ATP-binding cassette protein, putative 0.0019 0.0028 0.0125
Loa Loa (eye worm) RNA binding protein 0.0189 0.085 0.2617
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0107 0.0454 0.1394
Echinococcus granulosus FTZ F1 alpha 0.0071 0.0279 0.0279
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.002 0.0029 0.0089
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0024 0.0024
Echinococcus granulosus tubulin alpha 3 chain 0.0356 0.166 0.166
Mycobacterium tuberculosis Conserved protein 0.0107 0.0454 0.1394
Schistosoma mansoni hypothetical protein 0.0145 0.0636 0.0636
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Echinococcus multilocularis tubulin gamma 1 chain 0.0255 0.117 0.117
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus granulosus cpg binding protein 0.0093 0.0385 0.0385
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0739
Mycobacterium leprae Probable lipase LipE 0.0107 0.0454 0.9638
Schistosoma mansoni aldehyde dehydrogenase 0.0124 0.0537 0.0537
Plasmodium vivax tubulin beta chain, putative 0.0471 0.2216 1
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0088 0.0395
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0034 0.0097 0.0343
Echinococcus multilocularis neuropeptide receptor A26 0.0457 0.2149 0.2149
Brugia malayi ecdysteroid receptor 0.0071 0.0279 0.0991
Echinococcus granulosus beta tubulin 0.0471 0.2216 0.2216
Echinococcus multilocularis beta tubulin 0.0471 0.2216 0.2216
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.006 0.0226 0.0226
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0107 0.0454 0.1397
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0199 0.09 0.2772
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0031 0.0118
Onchocerca volvulus 0.0039 0.0124 0.0441
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0189 0.085 0.085
Schistosoma mansoni tar DNA-binding protein 0.0189 0.085 0.085
Plasmodium falciparum GAF domain-related protein, putative 0.002 0.0029 0.0131
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0457 0.2152 0.6627
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Trichomonas vaginalis tubulin, putative 0.0144 0.0633 0.2452
Brugia malayi nuclear hormone receptor 0.0071 0.0279 0.0991
Brugia malayi Blistered cuticle protein 3 0.0027 0.0063 0.0224
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0127 0.0575
Loa Loa (eye worm) hypothetical protein 0.0683 0.3247 1
Brugia malayi tubulin alpha chain - mouse 0.0356 0.166 0.5901
Loa Loa (eye worm) tubulin alpha 2 0.0101 0.0423 0.1304
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Trypanosoma cruzi hypothetical protein, conserved 0.0107 0.0454 0.2047
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0093 0.0286
Loa Loa (eye worm) hypothetical protein 0.0594 0.2813 0.8664
Echinococcus multilocularis tubulin alpha chain 0.0356 0.166 0.166
Trypanosoma cruzi diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus granulosus Tubulin beta 2C chain 0.0471 0.2216 0.2216
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0014 0 0.0002
Brugia malayi Tubulin gamma chain 0.0255 0.117 0.416
Echinococcus granulosus sphingosine kinase 1 0.0683 0.3247 0.3247
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0093 0.0286
Plasmodium vivax importin-beta 2, putative 0.0019 0.0024 0.011
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0088 0.0395
Onchocerca volvulus Chorion peroxidase homolog 0.0027 0.0063 0.0224
Trichomonas vaginalis tubulin beta chain, putative 0.0356 0.166 0.6425
Trichomonas vaginalis importin beta-1, putative 0.0015 0.0007 0.0028
Trichomonas vaginalis esterase, putative 0.0107 0.0454 0.1756
Echinococcus granulosus smad 0.0032 0.0091 0.0091
Schistosoma mansoni polycystin 1-related 0.0039 0.0124 0.0124
Trypanosoma brucei beta tubulin 0.0471 0.2216 1
Schistosoma mansoni tubulin subunit alpha 0.0111 0.0471 0.0471
Loa Loa (eye worm) beta-tubulin 0.0471 0.2216 0.6826
Trypanosoma cruzi importin beta-1 subunit, putative 0.0015 0.0007 0.0033
Brugia malayi Importin beta-1 subunit 0.0019 0.0024 0.0086
Plasmodium falciparum tubulin gamma chain 0.0255 0.117 0.5281
Loa Loa (eye worm) hypothetical protein 0.0025 0.0057 0.0175
Trypanosoma brucei alpha tubulin 0.0356 0.166 0.7491
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0862
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.027 0.1243 0.3829
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0088 0.0088
Schistosoma mansoni proteasome subunit alpha 6 (T01 family) 0.0027 0.0063 0.0063
Trypanosoma brucei epsilon tubulin 0.0255 0.117 0.5281
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0127 0.0392
Schistosoma mansoni tubulin subunit beta 0.0471 0.2216 0.2216
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0087 0.0358 0.1385
Echinococcus granulosus tubulin epsilon chain 0.0255 0.117 0.117
Mycobacterium tuberculosis Probable lipase LipD 0.0107 0.0454 0.1394
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0077 0.0077
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0088 0.0395
Echinococcus granulosus thyroid hormone receptor alpha 0.0034 0.0097 0.0097
Echinococcus granulosus tubulin alpha chain 0.0356 0.166 0.166
Treponema pallidum cell division protein FtsZ 0.0111 0.0471 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0124 0.0383
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0025 0.0109
Schistosoma mansoni tar DNA-binding protein 0.0189 0.085 0.085
Loa Loa (eye worm) nuclear hormone receptor 0.0034 0.0097 0.0297
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0019 0.0028 0.0125
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0038 0.0116 0.0116
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0014 0 0.0002
Brugia malayi Death domain containing protein 0.0122 0.0526 0.1868
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0071 0.0279 0.0991
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0071 0.0279 0.0991
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0025 0.0111
Brugia malayi MH2 domain containing protein 0.0476 0.2244 0.7976
Plasmodium vivax 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0685 0.3255 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0111 0.0471 1
Echinococcus granulosus neuropeptide receptor A26 0.0457 0.2149 0.2149
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.0191 0.0679
Echinococcus multilocularis ATP binding cassette sub family G 0.0019 0.0028 0.0028
Leishmania major epsilon tubulin, putative 0.0255 0.117 0.5281
Echinococcus multilocularis tubulin beta 1 chain 0.0471 0.2216 0.2216
Trichomonas vaginalis penicillin-binding protein, putative 0.0107 0.0454 0.1756
Trypanosoma brucei unspecified product 0.0019 0.0024 0.0109
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0034 0.0097 0.0097
Brugia malayi MH1 domain containing protein 0.0032 0.0091 0.0324
Brugia malayi Immunoglobulin I-set domain containing protein 0.0122 0.0526 0.1868
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0159 0.049
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.027 0.1243 0.4811
Echinococcus granulosus mothers against decapentaplegic 5 0.0032 0.0091 0.0091
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0159 0.049
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0031 0.0118
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0102 0.0461
Echinococcus granulosus ATP binding cassette sub family G 0.0019 0.0028 0.0028
Loa Loa (eye worm) tubulin beta chain 0.0471 0.2216 0.6826
Trichomonas vaginalis conserved hypothetical protein 0.0111 0.0471 0.1822
Echinococcus multilocularis Tubulin alpha 1 chain 0.0356 0.166 0.166
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Loa Loa (eye worm) CXXC zinc finger family protein 0.0088 0.0361 0.1111
Echinococcus multilocularis Tubulin beta 2C chain 0.0471 0.2216 0.2216
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0159 0.049
Echinococcus multilocularis ATP binding cassette sub family G 0.0019 0.0028 0.0028
Onchocerca volvulus 0.0499 0.2354 0.8369
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0454 0.1756
Giardia lamblia Epsilon tubulin 0.0111 0.0471 0.2122
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0174 0.0174
Brugia malayi Latrophilin receptor protein 2 0.0145 0.0636 0.2259
Leishmania major beta tubulin 0.0471 0.2216 1
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus granulosus RUN 0.0039 0.0124 0.0124
Giardia lamblia Beta tubulin 0.0471 0.2216 1
Onchocerca volvulus Ceramide kinase 1 homolog 0.0027 0.0063 0.0223
Toxoplasma gondii diacylglycerol kinase catalytic domain-containing protein 0.0027 0.0063 0.0284
Brugia malayi Tubulin beta-1 chain 0.0471 0.2216 0.7878
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0279 0.0279
Onchocerca volvulus Dual oxidase homolog 0.0027 0.0063 0.0224
Schistosoma mansoni loxhd1 0.0039 0.0124 0.0124
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Schistosoma mansoni alpha tubulin 0.0356 0.166 0.166
Brugia malayi hypothetical protein 0.0038 0.0116 0.0413
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.0199 0.0613
Onchocerca volvulus 0.0107 0.0454 0.1613
Schistosoma mansoni ABC transporter 0.0016 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0315
Leishmania major hypothetical protein, conserved 0.0053 0.0191 0.0862
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0025 0.0076
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0191 0.0862
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0031 0.0118
Schistosoma mansoni nuclear receptor 0.0034 0.0097 0.0097
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0032 0.0091 0.0091
Mycobacterium tuberculosis Conserved protein 0.0107 0.0454 0.1394
Onchocerca volvulus 0.0065 0.0247 0.0878
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0065 0.0247 0.0247
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0159 0.049
Mycobacterium tuberculosis Probable esterase LipL 0.0107 0.0454 0.1394
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0124 0.0537 0.2421
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0328 0.1524 0.4695
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0071 0.0279 0.0279
Schistosoma mansoni lamin 0.0055 0.0199 0.0199
Brugia malayi N-terminal motif family protein 0.0176 0.0789 0.2803
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus multilocularis lamin dm0 0.0055 0.0199 0.0199
Trichomonas vaginalis bmru protein, putative 0.0027 0.0063 0.0243
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0024 0.0024
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0088 0.0088
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0053 0.0191 0.0862
Echinococcus granulosus lamin dm0 0.0055 0.0199 0.0199
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0107 0.0453 0.2044
Mycobacterium leprae conserved hypothetical protein 0.0107 0.0454 0.9638
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0224
Echinococcus multilocularis geminin 0.1023 0.4895 0.4895
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.0031 0.0118
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0191 0.0739
Brugia malayi MH1 domain containing protein 0.0032 0.0091 0.0324
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0381 0.1781 0.1781
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Trypanosoma brucei beta tubulin 0.0255 0.117 0.5281
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0357
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Brugia malayi photoreceptor-specific nuclear receptor 0.0071 0.0279 0.0991
Onchocerca volvulus 0.0055 0.0199 0.0707
Leishmania major eukaryotic initiation factor 4a, putative 0.003 0.0077 0.0348
Plasmodium vivax phosphodiesterase gamma, putative 0.0053 0.0191 0.0862
Brugia malayi hypothetical protein 0.0034 0.0097 0.0343
Trypanosoma cruzi hypothetical protein, conserved 0.0053 0.0191 0.0862
Mycobacterium leprae conserved hypothetical protein 0.002 0.0029 0.0617
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0127 0.0127
Echinococcus multilocularis mothers against decapentaplegic 5 0.0032 0.0091 0.0091
Leishmania major delta tubulin, putative 0.0111 0.0471 0.2124
Echinococcus multilocularis ATP binding cassette sub family G 0.0019 0.0028 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.028 0.028
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.0109
Echinococcus multilocularis Diacylglycerol kinase theta 0.0027 0.0063 0.0063
Trichomonas vaginalis diacylglycerol kinase, epsilon, putative 0.0027 0.0063 0.0243
Trichomonas vaginalis conserved hypothetical protein 0.0107 0.0453 0.1753
Toxoplasma gondii diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Echinococcus granulosus tubulin alpha chain 0.0356 0.166 0.166
Toxoplasma gondii diacylglycerol kinase accessory domain (presumed) domain-containing protein 0.0027 0.0063 0.0284
Trichomonas vaginalis diacylglycerol kinase, zeta, iota, putative 0.0027 0.0063 0.0243
Entamoeba histolytica hypothetical protein 0.0071 0.028 0.0862
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0055 0.025
Giardia lamblia Alpha-tubulin 0.0356 0.166 0.749
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0124 0.0537 0.0537
Schistosoma mansoni nuclear hormone receptor 0.0034 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0313 0.145 0.145
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0224
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0065 0.0247 0.0247
Brugia malayi orphan nuclear receptor NR2E1 0.0034 0.0097 0.0343
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Mycobacterium tuberculosis Cell division protein FtsZ 0.0111 0.0471 0.1446
Schistosoma mansoni retinoic acid receptor RXR 0.0071 0.0279 0.0279
Brugia malayi Diacylglycerol kinase protein 2 0.0027 0.0063 0.0223
Trypanosoma brucei beta tubulin 0.0471 0.2216 1
Schistosoma mansoni camp-specific cyclic nucleotide phosphodiesterase 0.0053 0.0191 0.0191
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0024 0.0075
Trypanosoma cruzi tubulin gamma chain 0.0255 0.117 0.5281
Trypanosoma cruzi cAMP phosphodiesterase A, putative 0.0053 0.0191 0.0862
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0439 0.2062 0.635
Brugia malayi Tubulin beta chain 0.0111 0.0471 0.1673
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0077 0.0077
Onchocerca volvulus 0.0034 0.0097 0.0343
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0071 0.0279 0.0279
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0065 0.0247 0.0247
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0194
Echinococcus multilocularis tubulin epsilon chain 0.0255 0.117 0.117
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0034 0.0097 0.0097
Brugia malayi Doublecortin family protein 0.0039 0.0124 0.0441
Schistosoma mansoni alpha tubulin 0.0356 0.166 0.166
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Trichomonas vaginalis tubulin beta chain, putative 0.0471 0.2216 0.8577
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0071 0.0279 0.0859
Brugia malayi MH1 domain containing protein 0.0018 0.0021 0.0074
Trichomonas vaginalis helicase, putative 0.002 0.0031 0.0118
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0159 0.049
Brugia malayi Cell division protein ftsZ 0.0111 0.0471 0.1673
Echinococcus multilocularis sphingosine kinase 1 0.0683 0.3247 0.3247
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0071 0.0279 0.0859
Loa Loa (eye worm) hypothetical protein 0.0065 0.0247 0.0761
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.027 0.1243 0.4811
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0088 0.0088
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0088 0.0395
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0174 0.0174
Schistosoma mansoni alpha tubulin 0.0356 0.166 0.166
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0381 0.1781 0.1781
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0073 0.0286 0.1108
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Onchocerca volvulus 0.0039 0.0124 0.0441
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0174 0.0174
Echinococcus granulosus importin subunit beta 1 0.0019 0.0024 0.0024
Brugia malayi nuclear receptor NHR-67 0.0034 0.0097 0.0343
Echinococcus multilocularis musashi 0.0055 0.0199 0.0199
Brugia malayi Animal haem peroxidase family protein 0.0027 0.0063 0.0224
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0004 0.0013
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0107 0.0454 0.0454
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0124 0.0537 0.0537
Trichomonas vaginalis tubulin gamma chain, putative 0.0471 0.2216 0.8577
Trypanosoma brucei importin beta-1 subunit, putative 0.0019 0.0024 0.011
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.027 0.1243 0.4811
Echinococcus multilocularis tubulin alpha chain 0.0356 0.166 0.166
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0088 0.0395
Schistosoma mansoni inositol monophosphatase 0.004 0.0127 0.0127
Brugia malayi isocitrate dehydrogenase 0.0032 0.0088 0.0311
Brugia malayi diacylglycerol kinase 0.0027 0.0063 0.0223
Onchocerca volvulus 0.0144 0.0633 0.2252
Brugia malayi Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative 0.0053 0.0191 0.0679
Brugia malayi Tubulin alpha-2 chain 0.0356 0.166 0.5901
Echinococcus granulosus Nuclear hormone receptor HR96 0.0034 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0107 0.0454 0.1397
Trichomonas vaginalis conserved hypothetical protein 0.0053 0.0191 0.0739
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Onchocerca volvulus 0.0046 0.0159 0.0566
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0159 0.049
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Echinococcus multilocularis tubulin alpha 1C chain 0.0356 0.166 0.166
Loa Loa (eye worm) alpha-tubulin 0.0356 0.166 0.5113
Onchocerca volvulus Bile acid receptor homolog 0.0071 0.0279 0.0991
Trichomonas vaginalis tubulin beta chain, putative 0.0356 0.166 0.6425
Onchocerca volvulus 0.0027 0.0063 0.0223
Entamoeba histolytica diacylglycerol kinase, putative 0.0027 0.0063 0.0194
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Echinococcus multilocularis microtubule associated protein 2 0.2076 1 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0071 0.0279 0.0859
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0071 0.0279 0.0991
Brugia malayi alpha-tubulin 0.0356 0.166 0.5901
Onchocerca volvulus 0.0055 0.0199 0.0707
Echinococcus granulosus Tubulin alpha 1 chain 0.0356 0.166 0.166
Trypanosoma brucei epsilon tubulin 0.0255 0.117 0.5281
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Toxoplasma gondii histone lysine methyltransferase SET1 0.0169 0.0754 0.3401
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0038 0.0116 0.0116
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0186 0.0837 0.0837
Schistosoma mansoni tumor necrosis factor receptor related 0.0186 0.0837 0.0837
Echinococcus multilocularis acylglycerol kinase, mitochondrial 0.0027 0.0063 0.0063
Plasmodium vivax tubulin gamma chain, putative 0.0255 0.117 0.5281
Schistosoma mansoni DNA polymerase eta 0.0019 0.0024 0.0024
Trypanosoma cruzi Sphingosine kinase 0.0027 0.0063 0.0284
Brugia malayi diacylglycerol kinase 0.0027 0.0063 0.0223
Plasmodium falciparum 3',5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Brugia malayi nuclear receptor RXR 0.0034 0.0097 0.0343
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0357
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0189 0.085 0.2617
Schistosoma mansoni tubulin subunit beta 0.0471 0.2216 0.2216
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0111 0.0471 0.2124
Echinococcus multilocularis thyroid hormone receptor alpha 0.0071 0.0279 0.0279
Schistosoma mansoni calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase 0.0053 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.049
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.0107 0.0453 0.0453
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Brugia malayi Nuclear hormone receptor E75 0.0034 0.0097 0.0343
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0053 0.0191 0.0679
Echinococcus granulosus beta LACTamase domain containing family member 0.0107 0.0454 0.0454
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0014 0 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0107 0.0454 0.2047
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0739
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0007 0.0028
Trichomonas vaginalis tubulin beta chain, putative 0.0356 0.166 0.6425
Trichomonas vaginalis sphingosine kinase, putative 0.0027 0.0063 0.0243
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0159 0.3382
Plasmodium vivax tubulin alpha chain, putative 0.0356 0.166 0.7491
Onchocerca volvulus Peroxidase homolog 0.0027 0.0063 0.0224
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Echinococcus granulosus geminin 0.1023 0.4895 0.4895
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0122 0.0526 0.0526
Trichomonas vaginalis tubulin epsilon chain, putative 0.0471 0.2216 0.8577
Echinococcus granulosus Diacylglycerol kinase zeta 0.0027 0.0063 0.0063
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.002 0.0029 0.0089
Brugia malayi RNA, U transporter 1 0.0053 0.0191 0.068
Schistosoma mansoni hypothetical protein 0.0071 0.028 0.028
Trichomonas vaginalis ran, putative 0.0014 0 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus intermediate filament protein 0.0055 0.0199 0.0199
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Trichomonas vaginalis bmru protein, putative 0.0027 0.0063 0.0243
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0102 0.0315
Echinococcus granulosus mothers against decapentaplegic 6 0.0015 0.0004 0.0004
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0034 0.0097 0.0097
Schistosoma mansoni hypothetical protein 0.0145 0.0636 0.0636
Trichomonas vaginalis set domain proteins, putative 0.0499 0.2354 0.9112
Brugia malayi Nuclear hormone receptor-like 1 0.0038 0.0116 0.0413
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus multilocularis high affinity cAMP specific 3',5' cyclic 0.0053 0.0191 0.0191
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0457 0.2152 0.7648
Trichomonas vaginalis D-aminoacylase, putative 0.0107 0.0454 0.1756
Loa Loa (eye worm) tubulin alpha 2 0.0245 0.1123 0.3459
Schistosoma mansoni Smad4 0.0015 0.0004 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0063 0.0284
Leishmania major gamma-tubulin 0.0255 0.117 0.5281
Leishmania major sphingosine kinase A, B, putative 0.0027 0.0063 0.0284
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0024 0.0051 0.0051
Schistosoma mansoni inositol monophosphatase 0.004 0.0127 0.0127
Loa Loa (eye worm) BEN-1 protein 0.0471 0.2216 0.6826
Loa Loa (eye worm) hypothetical protein 0.0027 0.0063 0.0194
Schistosoma mansoni tubulin subunit alpha 0.0356 0.166 0.166
Leishmania major diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0071 0.0279 0.0991
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0029 0.0076 0.0234
Echinococcus multilocularis peroxidasin 0.0027 0.0063 0.0063
Leishmania major beta tubulin 0.0471 0.2216 1
Toxoplasma gondii GAF domain-containing protein 0.002 0.0029 0.0131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0071 0.0279 0.0859
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0127 0.0575
Trypanosoma brucei zeta tubulin 0.0111 0.0471 0.2124
Loa Loa (eye worm) hypothetical protein 0.0055 0.0199 0.0613
Echinococcus granulosus TGF beta signal transducer SmadC 0.0032 0.0091 0.0091
Echinococcus granulosus lipoxygenase domain containing protein 0.0039 0.0124 0.0124
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0071 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0018 0.0021 0.0064
Leishmania major hypothetical protein, conserved 0.0053 0.0191 0.0862
Leishmania major cAMP-specific phosphodiesterase, putative 0.0053 0.0191 0.0862
Schistosoma mansoni ap endonuclease 0.0019 0.0025 0.0025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0071 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0073 0.0286 0.0286
Trichomonas vaginalis tubulin beta chain, putative 0.0356 0.166 0.6425
Trichomonas vaginalis tubulin beta chain, putative 0.0144 0.0633 0.2452
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.028 0.028
Trichomonas vaginalis diacylglycerol kinase, putative 0.0027 0.0063 0.0243
Echinococcus multilocularis calcium:calmodulin dependent 3',5' cyclic 0.0053 0.0191 0.0191
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0194
Loa Loa (eye worm) glutaminase 2 0.0547 0.2584 0.7958
Toxoplasma gondii alpha tubulin TUBA1 0.0356 0.166 0.7491
Trichomonas vaginalis tubulin epsilon chain, putative 0.0356 0.166 0.6425
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0159 0.0489
Plasmodium vivax SET domain protein, putative 0.0065 0.0247 0.1115
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0279 0.0991
Echinococcus granulosus Polycystic kidney disease protein 0.0039 0.0124 0.0124
Schistosoma mansoni tubulin subunit beta 0.0471 0.2216 0.2216
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0127 0.0575
Echinococcus granulosus high affinity cAMP specific 3'5' cyclic 0.0053 0.0191 0.0191
Loa Loa (eye worm) hypothetical protein 0.0026 0.0062 0.019
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0053 0.0191 0.0739
Leishmania major hypothetical protein, conserved 0.0027 0.0063 0.0284
Loa Loa (eye worm) hypothetical protein 0.0034 0.0097 0.0297
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0145 0.0636 0.0636
Onchocerca volvulus 0.0107 0.0454 0.1613
Echinococcus multilocularis dnaJ subfamily B 0.0812 0.3869 0.3869
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0159 0.0718
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0024 0.0075
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0019 0.0028 0.0125
Brugia malayi Calcitonin receptor-like protein seb-1 0.0457 0.2152 0.7648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0279 0.0991
Schistosoma mansoni importin beta-1 0.0019 0.0024 0.0024
Trichomonas vaginalis tubulin beta chain, putative 0.0356 0.166 0.6425
Echinococcus granulosus tubulin subunit beta 0.0471 0.2216 0.2216
Brugia malayi hypothetical protein 0.0027 0.0063 0.0224
Schistosoma mansoni tubulin subunit beta 0.0471 0.2216 0.2216
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0145 0.0636 0.0636
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0038 0.0116 0.0116
Plasmodium falciparum tubulin beta chain 0.0471 0.2216 1
Echinococcus multilocularis peroxisome assembly protein 26 0.0356 0.166 0.166
Brugia malayi ecdysone receptor 0.0034 0.0097 0.0343
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0024 0.0074
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0024 0.0024
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0024 0.0086
Plasmodium falciparum diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Trypanosoma cruzi Diacylglycerol kinase catalytic domain containing protein, putative 0.0027 0.0063 0.0284
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Leishmania major cAMP phosphodiesterase A, putative;with=GeneDB:LinJ18_V3.1100 0.0053 0.0191 0.0862
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.0633 0.2452
Leishmania major alpha tubulin 0.0356 0.166 0.7491
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.0016 0.0012 0.0038
Trichomonas vaginalis tubulin epsilon chain, putative 0.0471 0.2216 0.8577
Brugia malayi MH2 domain containing protein 0.0015 0.0004 0.0015
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0381 0.1781 0.1781
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0381 0.1781 0.8038
Onchocerca volvulus Protein ultraspiracle homolog 0.0071 0.0279 0.0991
Schistosoma mansoni tubulin subunit epsilon 0.0255 0.117 0.117
Echinococcus multilocularis dna polymerase eta 0.0019 0.0024 0.0024
Plasmodium falciparum eukaryotic initiation factor 4A 0.003 0.0077 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0065 0.0247 0.0247
Trichomonas vaginalis tubulin epsilon chain, putative 0.0356 0.166 0.6425
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0357
Giardia lamblia Alpha-tubulin 0.0356 0.166 0.749
Schistosoma mansoni hypothetical protein 0.0145 0.0636 0.0636
Treponema pallidum ATP-dependent RNA helicase 0.003 0.0077 0.1174
Schistosoma mansoni cpg binding protein 0.0093 0.0385 0.0385
Loa Loa (eye worm) latrophilin receptor protein 2 0.0145 0.0636 0.1957
Loa Loa (eye worm) doublecortin family protein 0.0039 0.0124 0.0383
Trichomonas vaginalis tubulin alpha chain, putative 0.0255 0.117 0.453
Trypanosoma brucei cAMP phosphodiesterase A, putative 0.0053 0.0191 0.0862
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.0109
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0071 0.0279 0.0279
Trypanosoma brucei 3', 5'-cyclic nucleotide phosphodiesterase, putative 0.0053 0.0191 0.0862
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0145 0.0636 0.2259
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0107 0.0454 0.1394
Trypanosoma cruzi zeta tubulin, putative 0.0111 0.0471 0.2124
Loa Loa (eye worm) tubulin beta-4 chain 0.0471 0.2216 0.6826
Trichomonas vaginalis tubulin epsilon chain, putative 0.0111 0.0471 0.1822
Brugia malayi MH2 domain containing protein 0.0032 0.0091 0.0324
Loa Loa (eye worm) PDE1B protein 0.0053 0.0191 0.0588
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0107 0.0453 0.1753
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0071 0.0279 0.0279
Echinococcus multilocularis beta LACTamase domain containing family member 0.0107 0.0454 0.0454
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0015 0.0007 0.0028
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0159 0.0718
Echinococcus granulosus Tubulin alpha 1 chain 0.0356 0.166 0.166
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0174 0.0174
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0024 0.0109
Mycobacterium ulcerans diacylglycerol kinase 0.0027 0.0063 0.0194
Toxoplasma gondii beta-1 tubulin, putative 0.0471 0.2216 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0071 0.0279 0.0991
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.0031 0.0118
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0212 0.096 0.3717
Echinococcus granulosus tubulin alpha 3 chain 0.0356 0.166 0.166
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0034 0.0097 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0071 0.0279 0.0991
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Loa Loa (eye worm) inositol-1 0.004 0.0127 0.0392
Schistosoma mansoni Smad4 0.0015 0.0004 0.0004
Schistosoma mansoni hypothetical protein 0.0016 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0035 0.0102 0.0315
Toxoplasma gondii ABC1 family protein 0.0107 0.0454 0.2047
Loa Loa (eye worm) ceramide kinase 0.0027 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0038 0.0116 0.0357
Loa Loa (eye worm) hypothetical protein 0.0046 0.0159 0.049
Mycobacterium ulcerans hypothetical protein 0.0046 0.0159 0.049
Onchocerca volvulus 0.0027 0.0063 0.0224
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1057 0.1057
Onchocerca volvulus 0.0071 0.0279 0.0991
Brugia malayi nuclear hormone receptor family member odr-7 0.0034 0.0097 0.0343
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0029 0.0112
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0127 0.0127
Mycobacterium ulcerans hypothetical protein 0.0107 0.0454 0.1397
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0053 0.0191 0.0862
Echinococcus granulosus eukaryotic initiation factor 4A 0.003 0.0077 0.0077
Loa Loa (eye worm) tubulin alpha-3 chain 0.0212 0.096 0.2958
Plasmodium vivax diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Schistosoma mansoni lamin 0.0055 0.0199 0.0199
Loa Loa (eye worm) animal heme peroxidase 0.0027 0.0063 0.0194
Brugia malayi MH2 domain containing protein 0.0032 0.0091 0.0324
Loa Loa (eye worm) hypothetical protein 0.0019 0.0024 0.0075
Echinococcus granulosus acylglycerol kinase mitochondrial 0.0027 0.0063 0.0063
Leishmania major beta tubulin 0.0471 0.2216 1
Brugia malayi hypothetical protein 0.0232 0.1057 0.3756
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.003 0.0077 0.0077
Schistosoma mansoni netrin receptor unc5 0.0122 0.0526 0.0526
Trypanosoma brucei alpha tubulin 0.0356 0.166 0.7491
Echinococcus granulosus alpha tubulin 0.0356 0.166 0.166
Echinococcus granulosus ceramide kinase 0.0027 0.0063 0.0063
Echinococcus granulosus tubulin beta 1 chain 0.0471 0.2216 0.2216
Brugia malayi tailless protein 0.0034 0.0097 0.0343
Schistosoma mansoni lipoxygenase 0.0235 0.1073 0.1073
Loa Loa (eye worm) MH2 domain-containing protein 0.0032 0.0091 0.0281
Echinococcus granulosus high affinity cgmp specific 3' 5' cyclic 0.0053 0.0191 0.0191
Trichomonas vaginalis tubulin, putative 0.0471 0.2216 0.8577
Brugia malayi hypothetical protein 0.0034 0.0097 0.0343
Loa Loa (eye worm) hypothetical protein 0.0122 0.0526 0.1619
Trypanosoma cruzi cyclic nucleotide phosphodiesterase 0.0053 0.0191 0.0862
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0071 0.0279 0.0991
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0019 0.0028 0.0125
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0024 0.0109
Schistosoma mansoni hypothetical protein 0.0199 0.09 0.09
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0055 0.025
Brugia malayi conserved hypotetical protein 0.0034 0.0097 0.0343
Plasmodium falciparum alpha tubulin 1 0.0356 0.166 0.7491
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0107 0.0454 0.1394
Echinococcus granulosus calcium:calmodulin dependent 3'5' cyclic 0.0053 0.0191 0.0191
Schistosoma mansoni steroid hormone receptor ad4bp 0.0071 0.0279 0.0279
Onchocerca volvulus Peroxidase homolog 0.0027 0.0063 0.0224
Echinococcus granulosus death domain containing protein 0.0122 0.0526 0.0526
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0025 0.0096
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0235 0.1073 0.1073
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.0107 0.0453 0.0453
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0014 0 0.0002
Plasmodium vivax diacylglycerol kinase, putative 0.0027 0.0063 0.0284
Loa Loa (eye worm) intermediate filament protein 0.0055 0.0199 0.0613
Schistosoma mansoni nuclear hormone receptor 0.0071 0.0279 0.0279
Leishmania major beta tubulin 0.0471 0.2216 1
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0381 0.1781 0.1781
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0159 0.049
Schistosoma mansoni tubulin subunit beta 0.0471 0.2216 0.2216
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0073 0.0286 0.1108
Echinococcus multilocularis ecdysone induced protein 78C 0.0071 0.0279 0.0279
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0071 0.0279 0.0279

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 34 uM Inhibitory concentration against Hepatitis C virus serine protease ChEMBL. 15239657

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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