Detailed information for compound 207661

Basic information

Technical information
  • TDR Targets ID: 207661
  • Name: 3-butyl-8-methyl-1-propyl-7H-purine-2,6-dione
  • MW: 264.324 | Formula: C13H20N4O2
  • H donors: 1 H acceptors: 3 LogP: 2.16 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCn1c(=O)n(CCC)c(=O)c2c1nc([nH]2)C
  • InChi: 1S/C13H20N4O2/c1-4-6-8-16-11-10(14-9(3)15-11)12(18)17(7-5-2)13(16)19/h4-8H2,1-3H3,(H,14,15)
  • InChiKey: QMRNVBQRDCPVDY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-butyl-8-methyl-1-propyl-7H-purine-2,6-quinone
  • 81250-24-0
  • 3,7-Dihydro-3-butyl-8-methyl-1-propyl-1H-purine-2,6-dione
  • 1-Propyl-3-butyl-8-methylxanthine
  • 1H-Purine-2,6-dione, 3,7-dihydro-3-butyl-8-methyl-1-propyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei protein tyrosine phosphatase 1 0.0067 0.0346 0.5994
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Toxoplasma gondii histone deacetylase HDAC5 0.0024 0.0098 0.1695
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0008 0.0005 0.003
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0094 0.0598
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0003
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0112 0.0111
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.033 0.207
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Echinococcus granulosus ecdysone induced protein 78C 0.0007 0.0004 0.0004
Loa Loa (eye worm) acetyltransferase 0.0141 0.0769 0.0769
Echinococcus granulosus tar DNA binding protein 0.0068 0.0353 0.0353
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0007 0.0004 0.0004
Echinococcus granulosus histone deacetylase 6 0.0107 0.0577 0.0577
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0042 0.0042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.159 1
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0069 0.036 0.036
Mycobacterium tuberculosis Possible short-chain dehydrogenase EphD 0.0008 0.0005 0.003
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0004 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0007 0.0004 0.0004
Leishmania major short chain dehydrogenase-like protein 0.0008 0.0005 0.0082
Entamoeba histolytica 3-ketodihydrosphingosine reductase protein, putative 0.0008 0.0005 0.003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0067 0.0346 0.5994
Echinococcus granulosus Solute carrier family 22 5 0.1005 0.5729 0.5729
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.005 0.0049
Echinococcus multilocularis histone deacetylase 7 0.0107 0.0577 0.0577
Echinococcus multilocularis GPCR, family 2 0.0015 0.005 0.0049
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0005 0.0082
Onchocerca volvulus 0.0026 0.0112 0.1169
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0004 0.0003
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Trichomonas vaginalis pten, drome, putative 0.0067 0.0346 0.2178
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0094 0.0093
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Brugia malayi hypothetical protein 0.0008 0.0005 0.0005
Giardia lamblia Histone deacetylase 0.0083 0.0441 0.2745
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0082
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Plasmodium falciparum histone deacetylase, putative 0.0107 0.0577 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.033 0.0329
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Mycobacterium tuberculosis Probable short chain alcohol dehydrogenase/reductase 0.0008 0.0005 0.003
Onchocerca volvulus 0.0007 0.0004 0.0036
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0069 0.036 0.036
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trypanosoma cruzi histone deacetylase 1, putative 0.0083 0.0441 0.7628
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.033 0.0329
Echinococcus multilocularis Dehydrogenase:reductase SDR family 0.0008 0.0005 0.0005
Plasmodium falciparum steroid dehydrogenase, putative 0.0008 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Entamoeba histolytica Pten 3-phosphoinositide phosphatase, putative 0.0067 0.0346 0.2174
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Onchocerca volvulus 0.0067 0.0346 0.3625
Schistosoma mansoni pcd6 interacting protein-related 0.0067 0.0346 0.0346
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Echinococcus granulosus Dehydrogenase:reductase SDR family 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.005 0.0049
Trypanosoma cruzi histone deacetylase, putative 0.0107 0.0577 1
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0353 0.0353
Leishmania major short chain dehydrogenase, putative 0.0008 0.0005 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0004 0.0004
Leishmania major tyrosine specific protein phosphatase, putative 0.0067 0.0346 0.5994
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0083 0.0441 0.277
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0319 0.0318
Schistosoma mansoni rgs-gaip interacting protein gipc 0.0067 0.0346 0.0346
Echinococcus granulosus intermediate filament protein 0.0026 0.0112 0.0112
Leishmania major histone deacetylase, putative 0.0083 0.0441 0.7628
Trichomonas vaginalis short-chain dehydrogenases/reductase, putative 0.0008 0.0005 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Brugia malayi Histone deacetylase family protein 0.0107 0.0577 0.0577
Echinococcus granulosus hypothetical protein 0.0008 0.0005 0.0005
Mycobacterium tuberculosis Probable oxidoreductase 0.0279 0.1561 1
Toxoplasma gondii histone deacetylase HDAC1 0.0107 0.0577 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0007 0.0004 0.0004
Onchocerca volvulus 0.0067 0.0346 0.3625
Plasmodium vivax histone deacetylase, putative 0.0107 0.0577 1
Echinococcus multilocularis histone deacetylase 6 0.0107 0.0577 0.0577
Loa Loa (eye worm) dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0033 0.015 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0004 0.0003
Leishmania major protein-tyrosine phosphatase 1-like protein 0.0067 0.0346 0.5994
Treponema pallidum fructose-bisphosphate aldolase 0.0284 0.159 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.018 0.1125
Trypanosoma cruzi histone deacetylase, putative 0.0107 0.0577 1
Onchocerca volvulus 0.0008 0.0005 0.005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0094 0.0598
Loa Loa (eye worm) hypothetical protein 0.0026 0.0109 0.0109
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 1 0.0067 0.0346 0.0346
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.023 0.0229
Mycobacterium tuberculosis Probable dehydrogenase 0.0008 0.0005 0.003
Schistosoma mansoni protein-tyrosine phosphatase non-receptor type nt5 0.0067 0.0346 0.0346
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0007 0.0004 0.0003
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0007 0.0004 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0353 0.0352
Brugia malayi Dual specificity protein phosphatase CDC14B 0.0067 0.0346 0.0346
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0082
Loa Loa (eye worm) short chain dehydrogenase/reductase family oxidoreductase 0.0008 0.0005 0.0005
Mycobacterium tuberculosis Probable short-chain dehydrogenase/reductase 0.0008 0.0005 0.003
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0049
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0008 0.0005 0.5
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0005 0.003
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0005 0.005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1474 0.927
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Schistosoma mansoni intermediate filament proteins 0.0026 0.0112 0.0112
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0165 0.0906 0.0906
Echinococcus granulosus 3 ketodihydrosphingosine reductase 0.0008 0.0005 0.0005
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Mycobacterium ulcerans hypothetical protein 0.0023 0.0094 0.0598
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Brugia malayi ecdysteroid receptor 0.0007 0.0004 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0353 0.0352
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1474 0.927
Echinococcus granulosus epidermal retinal dehydrogenase 2 0.0008 0.0005 0.0005
Brugia malayi Histone deacetylase family protein 0.0107 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Echinococcus multilocularis hypothetical protein 0.0067 0.0346 0.0346
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Plasmodium vivax steroid dehydrogenase, putative 0.0008 0.0005 0.0082
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Giardia lamblia Fructose-bisphosphate aldolase 0.0284 0.159 1
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0008 0.0005 0.0082
Mycobacterium tuberculosis Possible fatty acyl-CoA reductase 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Echinococcus granulosus oxidoreductase 0.0008 0.0005 0.0005
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.033 0.0329
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.005 0.0049
Loa Loa (eye worm) dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0005 0.0082
Toxoplasma gondii carbonyl reductase 1, putative 0.0008 0.0005 0.0082
Brugia malayi ephrin receptor 1 precursor 0.0031 0.014 0.0139
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.018 0.3103
Brugia malayi Histone deacetylase 1 0.0083 0.0441 0.044
Mycobacterium ulcerans short chain dehydrogenase 0.0279 0.1561 1
Loa Loa (eye worm) protein-tyrosine-phosphatase 0.0067 0.0346 0.0346
Loa Loa (eye worm) histone deacetylase 0.0107 0.0577 0.0577
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0034
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1474 0.927
Onchocerca volvulus 0.0067 0.0346 0.3625
Trypanosoma cruzi quinonoid dihydropteridine reductase, putative 0.0008 0.0005 0.0082
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0139 0.0757 0.4849
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Onchocerca volvulus 0.0029 0.013 0.1357
Loa Loa (eye worm) histone deacetylase 11 0.0024 0.0098 0.0098
Toxoplasma gondii histone deacetylase HDAC2 0.0083 0.0441 0.7628
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.013 0.0129
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.023 0.0229
Echinococcus multilocularis histone deacetylase 3 0.0083 0.0441 0.044
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0139 0.0757 0.4849
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0082
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Mycobacterium leprae PROBABLE SHORT CHAIN ALCOHOL DEHYDROGENASE/REDUCTASE 0.0008 0.0005 0.0063
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.006
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0049
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0178 0.0983 0.0982
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0094 0.1618
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0005 0.0082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0007 0.0004 0.0004
Schistosoma mansoni steroid hormone receptor ad4bp 0.0007 0.0004 0.0004
Echinococcus granulosus neuropeptide receptor A26 0.0472 0.267 0.2669
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0008 0.0005 0.005
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0042 0.0042
Schistosoma mansoni protein tyrosine phosphatase 0.0067 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.175 1 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0007 0.0004 0.0004
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.036 0.036
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0094 0.0093
Echinococcus granulosus histone deacetylase 0.0107 0.0577 0.0577
Brugia malayi photoreceptor-specific nuclear receptor 0.0007 0.0004 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Mycobacterium leprae ROBABLE SHORT-CHAIN TYPE DEHYDROGENASE/REDUCTASE 0.0008 0.0005 0.0063
Loa Loa (eye worm) steroid hormone receptor 0.0007 0.0004 0.0003
Brugia malayi D-beta-hydroxybutyrate dehydrogenase, mitochondrial precursor 0.0008 0.0005 0.0005
Brugia malayi intermediate filament protein 0.0026 0.0112 0.0111
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0008 0.0005 0.0082
Trypanosoma brucei histone deacetylase 2 0.0024 0.0098 0.1695
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.023 0.0229
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.006
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1007 0.6336
Echinococcus multilocularis transient receptor potential cation channel 0.0008 0.0005 0.0005
Echinococcus multilocularis epidermal retinal dehydrogenase 2 0.0008 0.0005 0.0005
Brugia malayi Hypothetical oxidoreductase F56D1.5 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0083 0.0441 0.277
Loa Loa (eye worm) hypothetical protein 0.0083 0.0441 0.044
Trichomonas vaginalis histone deacetylase, putative 0.0083 0.0441 0.277
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0001 0.0004
Leishmania major histone deacetylase, putative 0.0107 0.0577 1
Entamoeba histolytica oxidoreductase, short chain dehydrogenase/reductase family 0.0008 0.0005 0.003
Echinococcus multilocularis histone deacetylase 8 0.0024 0.0098 0.0098
Onchocerca volvulus 0.0067 0.0346 0.3625
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0199 0.1254
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0082
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0082
Schistosoma mansoni cpg binding protein 0.0031 0.014 0.0139
Brugia malayi Nuclear hormone receptor-like 1 0.0007 0.0004 0.0003
Trypanosoma cruzi histone deacetylase, putative 0.0024 0.0098 0.1695
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0098
Brugia malayi Protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0007 0.0004 0.0004
Brugia malayi Steroid receptor seven-up type 2 0.0007 0.0004 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Mycobacterium ulcerans carveol-like dehydrogenase 0.0008 0.0005 0.003
Onchocerca volvulus 0.0067 0.0346 0.3625
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0082
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0005 0.003
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Leishmania major dehydrogenase-like protein 0.0008 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0005 0.003
Trypanosoma brucei beta-ketoacyl-ACP reductase 3, putative 0.0008 0.0005 0.0082
Onchocerca volvulus 0.0026 0.0112 0.1169
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0199 0.0199
Echinococcus multilocularis oxidoreductase 0.0008 0.0005 0.0005
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0005 0.0082
Onchocerca volvulus 4.1 G protein, putative homolog 0.0067 0.0346 0.3625
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.024 0.0239
Brugia malayi histone deacetylase 3 (HD3) 0.0083 0.0441 0.044
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0007 0.0004 0.0003
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Plasmodium vivax histone deacetylase 1, putative 0.0083 0.0441 0.7628
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Echinococcus granulosus hypothetical protein 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0031
Mycobacterium ulcerans dehydrogenase/decarboxylase protein 0.0008 0.0005 0.003
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0284 0.159 1
Onchocerca volvulus 0.0008 0.0005 0.005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0083 0.0436 0.0436
Brugia malayi nuclear hormone receptor 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Echinococcus multilocularis cpg binding protein 0.0031 0.014 0.0139
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0067 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0082
Mycobacterium ulcerans oxidoreductase 0.0008 0.0005 0.003
Loa Loa (eye worm) dual specificity protein phosphatase CDC14B 0.0067 0.0346 0.0346
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0061 0.5
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0094 0.0598
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0007 0.0004 0.0004
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.175 1 1
Mycobacterium tuberculosis Possible multi-functional enzyme with acyl-CoA-reductase activity AcrA1 0.0008 0.0005 0.003
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0112 0.0111
Echinococcus multilocularis geminin 0.0165 0.0906 0.0906
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0061 0.0384
Onchocerca volvulus 0.0008 0.0005 0.005
Schistosoma mansoni histone deacetylase 4 5 0.0107 0.0577 0.0577
Brugia malayi dehydrogenases, short chain protein 9 0.0008 0.0005 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Toxoplasma gondii histone deacetylase HDAC4 0.0024 0.0098 0.1695
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.036 0.036
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0178 0.0983 0.0982
Schistosoma mansoni histone deacetylase 0.0083 0.0441 0.044
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.023 0.0229
Leishmania major short chain dehydrogenase, putative 0.0008 0.0005 0.0082
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0082
Trichomonas vaginalis histone deacetylase, putative 0.0083 0.0441 0.277
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0178 0.0983 0.0982
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0082
Echinococcus multilocularis histone deacetylase 6 0.0107 0.0577 0.0577
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0012 0.0032 0.0031
Plasmodium falciparum histone deacetylase 2 0.0107 0.0577 1
Echinococcus multilocularis neuropeptide receptor A26 0.0472 0.267 0.2669
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0005 0.003
Trypanosoma cruzi histone deacetylase 1, putative 0.0083 0.0441 0.7628
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0353 0.0353
Schistosoma mansoni ephrin receptor 0.0065 0.0335 0.0335
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0007 0.0004 0.0003
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0005
Schistosoma mansoni histone deacetylase 4 5 0.0107 0.0577 0.0577
Onchocerca volvulus Glucosylceramidase homolog 0.0173 0.0954 1
Trypanosoma brucei histone deacetylase 4 0.0107 0.0577 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0004 0.0003
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0005 0.003
Trichomonas vaginalis histone deacetylase, putative 0.0083 0.0441 0.277
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi CXXC zinc finger family protein 0.0029 0.013 0.0129
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.033 0.0329
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0005 0.003
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1474 0.927
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0005 0.003
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0004 0.0003
Loa Loa (eye worm) protein tyrosine phosphatase 0.0067 0.0346 0.0346
Echinococcus multilocularis neuropeptide s receptor 0.0472 0.267 0.2669
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Echinococcus multilocularis retinol dehydrogenase 11 0.0008 0.0005 0.0005
Echinococcus multilocularis protein tyrosine phosphatase n9 0.0067 0.0346 0.0346
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Echinococcus granulosus steroid dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.036 0.036
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0013 0.0013
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Trypanosoma cruzi short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Brugia malayi hypothetical protein 0.0067 0.0346 0.0346
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0005 0.003
Echinococcus multilocularis lamin 0.0026 0.0112 0.0112
Brugia malayi TAR-binding protein 0.0068 0.0353 0.0352
Onchocerca volvulus Histone deacetylase 10 homolog 0.0024 0.0098 0.1025
Loa Loa (eye worm) hypothetical protein 0.0064 0.0331 0.033
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Echinococcus multilocularis 0.0067 0.0346 0.0346
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0083 0.0441 0.044
Echinococcus multilocularis receptor type tyrosine protein phosphatase zeta 0.0067 0.0346 0.0346
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0264 0.1474 0.1473
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0082
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0004 0.0004
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Echinococcus granulosus lamin dm0 0.0026 0.0112 0.0112
Brugia malayi Dehydrogenases, short chain protein 2 0.0008 0.0005 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.175 1 1
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0094 0.1233
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0094 0.0598
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Onchocerca volvulus 0.0067 0.0346 0.3625
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0005 0.003
Echinococcus granulosus histone deacetylase 7 0.0107 0.0577 0.0577
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Trypanosoma cruzi short chain dehydrogenase/reductase, putative 0.0008 0.0005 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0353 0.0353
Brugia malayi Latrophilin receptor protein 2 0.0015 0.005 0.0049
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0005 0.003
Schistosoma mansoni protein-tyrosine phosphatase n9 0.0067 0.0346 0.0346
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1474 0.927
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0007 0.0004 0.0003
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0007 0.0004 0.0003
Loa Loa (eye worm) histone deacetylase 3 0.0083 0.0441 0.044
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.006
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.023 0.0229
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0005 0.003
Onchocerca volvulus 0.0023 0.0094 0.0979
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0007 0.0004 0.0003
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0008 0.0005 0.0082
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.036 0.036
Trypanosoma brucei oxidoreductase-like protein 0.0008 0.0005 0.0082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.006
Trichomonas vaginalis steroid dehydrogenase, putative 0.0008 0.0005 0.0034
Plasmodium falciparum histone deacetylase 1 0.0083 0.0441 0.7628
Mycobacterium tuberculosis Possible iron-regulated short-chain dehydrogenase/reductase 0.0008 0.0005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0007 0.0004 0.0003
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0094 0.0598
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0007 0.0004 0.0003
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0005 0.0082
Trypanosoma brucei beta-ketoacyl-ACP reductase 2 0.0008 0.0005 0.0082
Schistosoma mansoni cpg binding protein 0.0029 0.013 0.013
Echinococcus granulosus histone deacetylase 8 0.0024 0.0098 0.0098
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.033 0.5706
Schistosoma mansoni histone deacetylase hda2 0.0024 0.0098 0.0098
Entamoeba histolytica estradiol 17-beta-dehydrogenase, putative 0.0008 0.0005 0.003
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0005 0.0082
Echinococcus granulosus ephrin type A receptor 4 A 0.0065 0.0335 0.0335
Plasmodium falciparum oxidoreductase, short-chain dehydrogenase family, putative 0.0008 0.0005 0.0082
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0067 0.0346 0.0346
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0061 0.0384
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.023 0.0229
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Onchocerca volvulus 0.0067 0.0346 0.3625
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0199 0.3446
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0094 0.0587
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Trichomonas vaginalis histone deacetylase, putative 0.0083 0.0441 0.277
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0199 0.3446
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0005 0.0082
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0061 0.1039
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0264 0.1474 0.1473
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0067 0.0346 0.2174
Schistosoma mansoni retinal dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0005 0.0005
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0.0005 0.003
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0008 0.0005 0.005
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0067 0.0346 0.0346
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0048 0.024 0.0239
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0055 0.0349
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0094 0.0093
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0005 0.003
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0005 0.0082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0055 0.0349
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.005 0.0049
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0175 0.0174
Brugia malayi Protein-tyrosine phosphatase 1 0.0067 0.0346 0.0346
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0061 0.1039
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Leishmania major 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0007 0.0004 0.0004
Brugia malayi oxidoreductase 0.0008 0.0005 0.0005
Schistosoma mansoni lamin 0.0026 0.0112 0.0112
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Schistosoma mansoni RAR-like nuclear receptor 0.0007 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Mycobacterium ulcerans dehydrogenase/reductase 0.0008 0.0005 0.003
Onchocerca volvulus 0.0067 0.0346 0.3625
Echinococcus granulosus geminin 0.0165 0.0906 0.0906
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.03 0.5196
Onchocerca volvulus 0.0008 0.0005 0.005
Trypanosoma cruzi histone deacetylase, putative 0.0024 0.0098 0.1695
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0094 0.0598
Schistosoma mansoni 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Echinococcus granulosus FTZ F1 alpha 0.0007 0.0004 0.0004
Onchocerca volvulus 0.0067 0.0346 0.3625
Onchocerca volvulus 0.0008 0.0005 0.005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0067 0.0346 0.0346
Trypanosoma brucei histone deacetylase 3 0.0107 0.0577 1
Loa Loa (eye worm) fibronectin type III domain-containing protein 0.0069 0.036 0.036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0007 0.0004 0.0003
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Echinococcus granulosus histone deacetylase 3 0.0083 0.0441 0.044
Brugia malayi histone deacetylase 1 (HD1) 0.0083 0.0441 0.044
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0178 0.0983 0.0982
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0008 0.0005 0.0082
Trypanosoma cruzi 3-ketoacyl-CoA reductase, putative 0.0008 0.0005 0.0082
Echinococcus multilocularis histone deacetylase 6 0.0107 0.0577 0.0577
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0094 0.0587
Trypanosoma brucei histone deacetylase 1 0.0083 0.0441 0.7628
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0178 0.0983 0.0982
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0769 0.0769
Onchocerca volvulus 0.0008 0.0005 0.005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0004 0.0003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) RNA binding protein 0.0068 0.0353 0.0352
Loa Loa (eye worm) hypothetical protein 0.0015 0.005 0.0049
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0007 0.0004 0.0004
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Mycobacterium tuberculosis Probable short-chain type oxidoreductase 0.0008 0.0005 0.003
Schistosoma mansoni lamin 0.0026 0.0112 0.0112
Loa Loa (eye worm) histone deacetylase 7A 0.0107 0.0577 0.0577
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0094 0.1618
Mycobacterium tuberculosis Possible ketoacyl reductase 0.0008 0.0005 0.003
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0013
Mycobacterium ulcerans short-chain membrane-associated dehydrogenase 0.0008 0.0005 0.003
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.036 0.036
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0014 0.0013
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.033 0.5706
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0769 0.0769
Trichomonas vaginalis antibiotic synthetase, putative 0.0007 0.0001 0.0004
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0353 0.0352
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0067 0.0346 0.0346
Schistosoma mansoni histone deacetylase hda2 0.0107 0.0577 0.0577
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0034 0.0034
Trypanosoma cruzi beta-ketoacyl-ACP reductase 2, putative 0.0008 0.0005 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.005 0.0049
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.0069 0.036 0.036
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0007 0.0004 0.0004
Brugia malayi hypothetical protein 0.0067 0.0346 0.0346
Onchocerca volvulus 0.0067 0.0346 0.3625
Schistosoma mansoni oxidoreductase short chain dehydrogenase/reductase family 0.0008 0.0005 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0008 0.0005 0.0082
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis glucosylceramidase, putative 0.0264 0.1474 0.927
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0067 0.0346 0.0346
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0005 0.003
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi RNA binding protein 0.0068 0.0353 0.0352
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Echinococcus granulosus histone deacetylase 6 0.0107 0.0577 0.0577
Schistosoma mansoni coup transcription factor 0.0007 0.0004 0.0004
Echinococcus multilocularis ecdysone induced protein 78C 0.0007 0.0004 0.0004
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0175 0.0174
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0178 0.0983 0.0982
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0007 0.0004 0.0004
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Echinococcus multilocularis ephrin type A receptor 4 A 0.0065 0.0335 0.0335
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Toxoplasma gondii oxidoreductase, putative 0.0008 0.0005 0.0082
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.018 0.1099
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Echinococcus granulosus Receptor type tyrosine protein phosphatase O 0.0067 0.0346 0.0346
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0353 0.0353
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi histone deacetylase 11 0.0024 0.0098 0.0098
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.033 0.0329
Mycobacterium tuberculosis Possible oxidoreductase 0.0008 0.0005 0.003
Brugia malayi Dehydrogenases, short chain protein 30 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0067 0.0346 0.3625
Trichomonas vaginalis histone deacetylase, putative 0.0083 0.0441 0.277
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0004 0.0004
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Mycobacterium leprae Possible short-chain dehydrogenase EphD 0.0008 0.0005 0.0063
Schistosoma mansoni retinoic acid receptor RXR 0.0007 0.0004 0.0004
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0007 0.0004 0.0004
Schistosoma mansoni receptor protein tyrosine phosphatase 0.0069 0.036 0.036
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Onchocerca volvulus 0.0008 0.0005 0.005
Leishmania major oxidoreductase-like protein 0.0008 0.0005 0.0082
Echinococcus multilocularis receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type 0.0067 0.0346 0.0346
Trypanosoma cruzi 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0082
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0034 0.0034
Echinococcus granulosus retinol dehydrogenase 11 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0007 0.0004 0.0003
Trypanosoma brucei beta-D-hydroxybutyrate dehydrogenase 0.0008 0.0005 0.0082
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0353 0.0353
Echinococcus multilocularis receptor type tyrosine protein phosphatase H 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Schistosoma mansoni cpg binding protein 0.0031 0.014 0.0139
Echinococcus granulosus lamin 0.0026 0.0112 0.0112
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0082
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0067 0.0346 0.0346
Brugia malayi hypothetical protein 0.0067 0.0346 0.0346
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0007 0.0004 0.0003
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0008 0.0005 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0055 0.0349
Echinococcus multilocularis conserved hypothetical protein 0.0008 0.0005 0.0005
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0023 0.0094 0.1233
Schistosoma mansoni protein tyrosine phosphatase 0.0069 0.036 0.036
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0199 0.1254
Schistosoma mansoni hypothetical protein 0.0033 0.0152 0.0151
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Mycobacterium leprae Probable oxidoreductase 0.0008 0.0005 0.0063
Brugia malayi steroid hormone receptor 0.0007 0.0004 0.0003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.005 0.0049
Onchocerca volvulus Sepiapterin reductase homolog 0.0008 0.0005 0.005
Onchocerca volvulus 0.0008 0.0005 0.005
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0093
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.023 0.0229
Onchocerca volvulus 0.0008 0.0005 0.005
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0007 0.0004 0.0036
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Echinococcus granulosus histone deacetylase 1 0.0083 0.0441 0.044
Onchocerca volvulus 0.0067 0.0346 0.3625
Plasmodium vivax histone deacetylase, putative 0.0024 0.0098 0.1695
Onchocerca volvulus 0.0008 0.0005 0.005
Loa Loa (eye worm) hypothetical protein 0.0017 0.0061 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.023 0.0229
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Schistosoma mansoni thyroid hormone receptor 0.0007 0.0004 0.0004
Plasmodium vivax histone deacetylase 2, putative 0.0107 0.0577 1
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Toxoplasma gondii oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0082
Mycobacterium ulcerans ketoacyl reductase 0.0008 0.0005 0.003
Entamoeba histolytica hypothetical protein, conserved 0.0008 0.0005 0.003
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0353 0.0353
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Echinococcus multilocularis FTZ F1 alpha 0.0007 0.0004 0.0004
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0747 0.0746
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.175 1 1
Trichomonas vaginalis glucosylceramidase, putative 0.0182 0.1007 0.6336
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Brugia malayi protein-tyrosine phosphatase Lar-like precursor, putative 0.0067 0.0346 0.0346
Schistosoma mansoni short-chain dehydrogenase/reductase 0.0008 0.0005 0.0005
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Brugia malayi hypothetical protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0178 0.0983 0.0982
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Schistosoma mansoni hypothetical protein 0.0165 0.0906 0.0906
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Trypanosoma brucei histone deacetylase, putative 0.0107 0.0577 1
Toxoplasma gondii sterol carrier protein-2 HAD-2SCP-2 0.0008 0.0005 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0094 0.0598
Onchocerca volvulus Protein ultraspiracle homolog 0.0007 0.0004 0.0036
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.033 0.5706
Echinococcus granulosus protein tyrosine phosphatase n9 0.0067 0.0346 0.0346
Echinococcus granulosus cpg binding protein 0.0031 0.014 0.0139
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Mycobacterium tuberculosis Probable oxidoreductase 0.0008 0.0005 0.003
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0007 0.0004 0.0004
Mycobacterium ulcerans short-chain dehydrogenase 0.0008 0.0005 0.003
Echinococcus multilocularis estradiol 17 beta dehydrogenase 12 0.0008 0.0005 0.0005
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Echinococcus multilocularis retinol dehydrogenase 13 0.0008 0.0005 0.0005
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0055 0.0349
Leishmania major histone deacetylase, putative 0.0083 0.0441 0.7628
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Leishmania major short chain dehydrogenase/reductase, putative 0.0008 0.0005 0.0082
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0082
Echinococcus granulosus histone deacetylase 6 0.0107 0.0577 0.0577
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0007 0.0004 0.0004
Trichomonas vaginalis hydroxyacyl dehydrogenase, putative 0.0008 0.0005 0.0034
Onchocerca volvulus 0.0067 0.0346 0.3625
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0049
Trichomonas vaginalis short-chain dehydrogenase, putative 0.0008 0.0005 0.0034
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.0069 0.036 0.036
Echinococcus granulosus carbonyl reductase 1 0.0008 0.0005 0.0005
Toxoplasma gondii histone deacetylase HDAC3 0.0083 0.0441 0.7628
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.0069 0.036 0.036
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0064 0.0331 0.3464
Brugia malayi nuclear receptor NHR-88 0.0007 0.0004 0.0003
Mycobacterium tuberculosis Probable shortchain dehydrogenase 0.0008 0.0005 0.003
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0769 0.0769
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0139 0.0757 1
Leishmania major pteridine reductase 1 0.0008 0.0005 0.0082
Schistosoma mansoni receptor protein tyrosine phosphatase n (ia2) 0.0067 0.0346 0.0346
Echinococcus multilocularis lamin dm0 0.0026 0.0112 0.0112
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Trichomonas vaginalis histone deacetylase, putative 0.0083 0.0441 0.277
Brugia malayi Retinol dehydrogenase 12 0.0008 0.0005 0.0005
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Onchocerca volvulus 0.0067 0.0346 0.3625
Giardia lamblia Protein tyrosine phosphatase 0.0067 0.0346 0.2151
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0094 0.0598
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Loa Loa (eye worm) histone deacetylase 1 0.0083 0.0441 0.044
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Mycobacterium ulcerans oxidoreductase 0.0008 0.0005 0.003
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.024 0.0239
Echinococcus granulosus neuropeptide s receptor 0.0472 0.267 0.2669
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0033 0.0152 0.0151
Trypanosoma brucei 3-keto-dihydrosphingosine reductase 0.0008 0.0005 0.0082
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Brugia malayi hypothetical protein 0.0008 0.0005 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0067 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Echinococcus multilocularis histone deacetylase 0.0107 0.0577 0.0577
Brugia malayi hypothetical protein 0.0067 0.0346 0.0346
Mycobacterium ulcerans short-chain type oxidoreductase 0.0008 0.0005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0007 0.0004 0.0003
Echinococcus multilocularis musashi 0.0026 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0026 0.0112 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0007 0.0004 0.0003
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0014 0.0013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0093
Schistosoma mansoni protein tyrosine phosphatase 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Leishmania major quinonoid dihydropteridine reductase 0.0008 0.0005 0.0082
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.024 0.0239
Trypanosoma cruzi hypothetical protein, conserved 0.0008 0.0005 0.0082
Schistosoma mansoni histone deacetylase 1 2 3 0.0024 0.0098 0.0098
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0082
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0094 0.0093
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Entamoeba histolytica histone deacetylase, putative 0.0083 0.0441 0.2767
Schistosoma mansoni hypothetical protein 0.0015 0.005 0.0049
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Onchocerca volvulus Bile acid receptor homolog 0.0007 0.0004 0.0036
Schistosoma mansoni carbonyl reductase 0.0008 0.0005 0.0005
Schistosoma mansoni short chain dehydrogenase 0.0008 0.0005 0.0005
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0083 0.0441 0.277
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Onchocerca volvulus 0.0067 0.0346 0.3625
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.023 0.0229
Trypanosoma brucei short-chain dehydrogenase, putative 0.0008 0.0005 0.0082
Toxoplasma gondii 3-ketoacyl-CoA reductase, putative 0.0008 0.0005 0.0082
Echinococcus granulosus GPCR family 2 0.0015 0.005 0.0049
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0067 0.0346 0.0346
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0112 0.0111
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0007 0.0004 0.0004
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0284 0.159 1
Echinococcus multilocularis carbonyl reductase 1 0.0008 0.0005 0.0005
Echinococcus multilocularis Receptor type tyrosine protein phosphatase O 0.0069 0.036 0.036
Trypanosoma cruzi histone deacetylase, putative 0.0107 0.0577 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0067 0.0346 0.0346
Echinococcus granulosus WW domain containing oxidoreductase 0.0008 0.0005 0.0005
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 13 homolog 0.0008 0.0005 0.005
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0067 0.0346 0.0346
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Loa Loa (eye worm) oxidoreductase 0.0008 0.0005 0.0005
Brugia malayi dehydrogenases, short chain protein 2 0.0008 0.0005 0.0005
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0094 0.0598
Trichomonas vaginalis estradiol 17 beta-dehydrogenase, putative 0.0008 0.0005 0.0034
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Onchocerca volvulus 0.0067 0.0346 0.3625
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0007 0.0004 0.0003
Echinococcus multilocularis 3 ketodihydrosphingosine reductase 0.0008 0.0005 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.036 0.036
Onchocerca volvulus 0.0067 0.0346 0.3625
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Mycobacterium ulcerans short chain dehydrogenase 0.0008 0.0005 0.003
Leishmania major histone deacetylase, putative 0.0107 0.0577 1
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0199 0.3446
Entamoeba histolytica hypothetical protein 0.0008 0.0005 0.003
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0007 0.0004 0.0003
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0004 0.0003
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0067 0.0346 0.5994
Leishmania major hypothetical protein, conserved 0.0008 0.0005 0.0082
Onchocerca volvulus 0.0014 0.0044 0.0457
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.033 0.5706
Mycobacterium tuberculosis Decaprenylphosphoryl-D-2-keto erythro pentose reductase 0.0008 0.0005 0.003
Schistosoma mansoni receptor protein tyrosine phosphatase r (pcptp1) 0.0067 0.0346 0.0346
Trypanosoma brucei 3-ketoacyl-CoA reductase, putative 0.0008 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0083 0.0441 0.044
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0067 0.0346 0.2174
Echinococcus multilocularis thyroid hormone receptor alpha 0.0007 0.0004 0.0004
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0007 0.0004 0.0003
Mycobacterium ulcerans dehydrogenase 0.0008 0.0005 0.003
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.0063
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0152 0.0151
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0008 0.0005 0.0005
Trypanosoma cruzi tyrosine specific protein phosphatase, putative 0.0067 0.0346 0.5994
Schistosoma mansoni steroid dehydrogenase 0.0008 0.0005 0.0005
Echinococcus granulosus receptor type tyrosine protein phosphatase zeta 0.0069 0.036 0.036
Onchocerca volvulus Dehydrogenase\/reductase SDR family member 1 homolog 0.0008 0.0005 0.005
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Schistosoma mansoni non-receptor protein-tyrosine phosphatase 0.0067 0.0346 0.0346
Mycobacterium leprae Probable short-chain type dehydrogenase/reductase 0.0008 0.0005 0.0063
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0008 0.0005 0.0005
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Brugia malayi Protein-tyrosine phosphatase 0.0069 0.036 0.036
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0008 0.0005 0.003
Echinococcus multilocularis histone deacetylase 1 0.0083 0.0441 0.044
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0094 0.1618
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0008 0.0005 0.0005
Entamoeba histolytica short chain dehydrogenase family protein 0.0008 0.0005 0.003
Loa Loa (eye worm) hypothetical protein 0.0008 0.0005 0.0005
Trypanosoma cruzi NAD(P)-dependent oxidoreductase, putative 0.0008 0.0005 0.0082
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0067 0.0346 0.0346
Trypanosoma cruzi short chain dehydrogenase, putative 0.0008 0.0005 0.0082
Loa Loa (eye worm) hypothetical protein 0.0067 0.0346 0.0346
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0067 0.0346 0.0346
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.0954 0.6
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.0069 0.036 0.036
Echinococcus multilocularis steroid dehydrogenase 0.0008 0.0005 0.0005
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0094 0.0587
Schistosoma mansoni histone deacetylase 0.0083 0.0441 0.044
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0067 0.0346 0.0346

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 375 uM Inhibitory activity of the compound was tested against human cytosolic phosphoenolpyruvate carboxykinase (PEPCK) enzyme ChEMBL. 14505680

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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