Detailed information for compound 209348

Basic information

Technical information
  • TDR Targets ID: 209348
  • Name: 2,5-bis[(3-fluorophenyl)methoxy]-1,6-bis(phen ylmethoxy)hexane-3,4-diol
  • MW: 578.643 | Formula: C34H36F2O6
  • H donors: 2 H acceptors: 2 LogP: 4.71 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(C(C(OCc1cccc(c1)F)COCc1ccccc1)O)C(OCc1cccc(c1)F)COCc1ccccc1
  • InChi: 1S/C34H36F2O6/c35-29-15-7-13-27(17-29)21-41-31(23-39-19-25-9-3-1-4-10-25)33(37)34(38)32(24-40-20-26-11-5-2-6-12-26)42-22-28-14-8-16-30(36)18-28/h1-18,31-34,37-38H,19-24H2
  • InChiKey: FHAHJYSCDBWYGW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1,6-dibenzyloxy-2,5-bis[(3-fluorophenyl)methoxy]hexane-3,4-diol
  • 1,6-dibenzoxy-2,5-bis[(3-fluorobenzyl)oxy]hexane-3,4-diol
  • 1,6-bis(benzyloxy)-2,5-bis[(3-fluorobenzyl)oxy]hexane-3,4-diol

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human immunodeficiency virus 1 Human immunodeficiency virus type 1 protease Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) Get druggable targets OG5_131408 All targets in OG5_131408
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus multilocularis Chromobox protein 3 Human immunodeficiency virus type 1 protease   99 aa 95 aa 28.4 %
Mycobacterium leprae Hypothetical protein Human immunodeficiency virus type 1 protease   99 aa 86 aa 27.9 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Giardia lamblia DNA-directed RNA polymerase subunit D Human immunodeficiency virus type 1 protease   99 aa 90 aa 27.8 %
Entamoeba histolytica retroviral aspartyl protease domain-containing protein Human immunodeficiency virus type 1 protease   99 aa 103 aa 31.1 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Candida albicans dethiobiotin synthetase Human immunodeficiency virus type 1 protease   99 aa 90 aa 22.2 %
Trypanosoma brucei variant surface glycoprotein (VSG), putative Human immunodeficiency virus type 1 protease   99 aa 80 aa 27.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus granulosus tachykinin peptides receptor 99D 0.0109 0.0111 0.011
Loa Loa (eye worm) solute carrier family 6 member 4 0.0535 0.0647 0.0646
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0024 0.0024
Schistosoma mansoni neuropeptide receptor 0.0109 0.0111 0.011
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0019 0.094
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0036 0.0036
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.005 0.0036 0.0036
Mycobacterium tuberculosis Conserved protein 0.0035 0.0017 0.0341
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Brugia malayi Serotonin receptor 0.0109 0.0111 0.0111
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.0068 0.0067
Mycobacterium ulcerans lipase LipD 0.0035 0.0017 0.0805
Onchocerca volvulus 0.012 0.0125 0.0374
Leishmania major ATP-dependent phosphofructokinase 0.011 0.0112 0.015
Echinococcus multilocularis synaptic vesicular amine transporter 0.019 0.0213 0.0212
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0006 0.0005
Onchocerca volvulus Vesicular acetylcholine transporter homolog 0.2661 0.332 1
Echinococcus granulosus neuropeptide receptor A26 0.0109 0.0111 0.011
Plasmodium vivax glutathione reductase, putative 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus multilocularis protein kinase c epsilon type 0.0885 0.1087 0.1087
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Brugia malayi G-protein coupled receptor 0.0109 0.0111 0.0111
Echinococcus multilocularis protein kinase c eta type 0.0212 0.024 0.024
Echinococcus granulosus bloom syndrome protein 0.0042 0.0026 0.0026
Plasmodium vivax topoisomerase I, putative 0.7972 1 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0111 0.011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0159 0.0174 0.0173
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0032 0.0042
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0584 0.0708 0.0708
Echinococcus multilocularis neuropeptide s receptor 0.0109 0.0111 0.011
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0037 0.002 0.0019
Loa Loa (eye worm) hypothetical protein 0.0829 0.1016 0.1016
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.012 0.0125 0.0124
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.005 0.0036 0.0036
Schistosoma mansoni serine/threonine protein kinase 0.0212 0.024 0.024
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.005 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0035 0.0017 0.0022
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.019 0.6622
Echinococcus granulosus serotonin transporter 0.0535 0.0647 0.0646
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0272 0.0271
Loa Loa (eye worm) hypothetical protein 0.0224 0.0256 0.0255
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0011 0.0368
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.0088 0.0087
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0112 0.2161
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0372 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0584 0.0708 0.0708
Trypanosoma brucei C2 domain/Ankyrin repeats (3 copies), putative 0.0021 0 0.0000000034972
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.005 0.0036 0.0036
Brugia malayi Latrophilin receptor protein 2 0.0031 0.0013 0.0013
Trichomonas vaginalis set domain proteins, putative 0.0234 0.0267 0.93
Schistosoma mansoni Lamin B receptor (ERG24) 0.0093 0.0091 0.009
Schistosoma mansoni neuropeptide receptor 0.0109 0.0111 0.011
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0011 0.0011
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0111 0.011
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0009 0.0008
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0205 0.0232 0.0231
Brugia malayi Dopamine receptor protein 2 0.0109 0.0111 0.0111
Schistosoma mansoni biogenic amine receptor 0.0109 0.0111 0.011
Echinococcus multilocularis lamin dm0 0.0026 0.0007 0.0006
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Echinococcus granulosus neuropeptide receptor 0.0109 0.0111 0.011
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0017 0.0805
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Echinococcus granulosus DNA topoisomerase 1 0.7972 1 1
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0091 0.0088 0.0087
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0212 0.024 0.024
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0006 0.0007
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0037 0.002 0.1082
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0037 0.002 0.0019
Echinococcus granulosus Rac GTPase activating protein 1 0.0212 0.024 0.024
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.0053 0.0041 0.004
Brugia malayi Protein kinase c protein 2 0.0677 0.0825 0.0825
Brugia malayi G protein-coupled receptor 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0307 0.0359 0.0359
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0032 0.0031
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0002 0.0002
Schistosoma mansoni opsin-like receptor 0.0109 0.0111 0.011
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0109 0.0111 0.0111
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0272 0.0271
Echinococcus granulosus protein kinase c eta type 0.0212 0.024 0.024
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0011 0.001
Leishmania major cytochrome p450-like protein 0.0028 0.0009 0.0011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0109 0.0111 0.011
Plasmodium falciparum glutathione reductase 0.0047 0.0032 0.0032
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0109 0.0111 0.0111
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0016 0.0016
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0031 0.0013 0.0013
Trichomonas vaginalis DNA helicase recq1, putative 0.0042 0.0026 0.0903
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) LGC-31 protein 0.005 0.0036 0.0036
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0111 0.011
Entamoeba histolytica protein kinase, putative 0.0237 0.0272 0.524
Leishmania major cytochrome p450-like protein 0.0037 0.002 0.0026
Brugia malayi hypothetical protein 0.0026 0.0006 0.0006
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0109 0.0111 0.011
Brugia malayi Pre-SET motif family protein 0.0029 0.0011 0.0011
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0037 0.002 0.0019
Echinococcus granulosus sodium and chloride dependent glycine 0.0091 0.0088 0.0087
Echinococcus granulosus protein kinase c iota type 0.0697 0.085 0.085
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0018 0.0018
Schistosoma mansoni lamin 0.0026 0.0007 0.0006
Schistosoma mansoni protein kinase C 0.0234 0.0267 0.0267
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0019 0.0018
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0272 0.0271
Mycobacterium tuberculosis Probable reductase 0.0106 0.0107 0.403
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus multilocularis serine:threonine protein kinase N2 0.0237 0.0272 0.0271
Brugia malayi neuropeptide F receptor 0.0109 0.0111 0.0111
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0036 0.0036
Schistosoma mansoni unc-13 (munc13) 0.0234 0.0267 0.0267
Onchocerca volvulus 0.0109 0.0111 0.0333
Loa Loa (eye worm) hypothetical protein 0.0535 0.0647 0.0646
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.005 0.0036 0.0036
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0011 0.0368
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0017 0.0341
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0052 0.0051
Echinococcus granulosus lamin dm0 0.0026 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0212 0.024 0.024
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0027 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0068 0.0059 0.0058
Echinococcus granulosus GPCR family 2 0.0031 0.0013 0.0013
Brugia malayi C1-like domain containing protein 0.0584 0.0708 0.0708
Schistosoma mansoni family A2 unassigned peptidase (A02 family) 0.0278 0.0323 0.0322
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0237 0.0272 0.0271
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0107 0.403
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus granulosus unc 13 munc13 0.0234 0.0267 0.0267
Brugia malayi vesicular acetylcholine transporter unc-17 0.2661 0.332 0.332
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0535 0.0647 0.0646
Entamoeba histolytica protein kinase, putative 0.025 0.0287 0.554
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.005 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0287 0.9997
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0017 0.0341
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0111 0.011
Echinococcus multilocularis serotonin receptor 0.0109 0.0111 0.011
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0053 0.0041 0.004
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0122 1
Echinococcus multilocularis NMDA receptor 0.0053 0.0041 0.004
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0018 0.0915
Echinococcus multilocularis nAChR subunit 0.005 0.0036 0.0036
Echinococcus granulosus nmda type glutamate receptor 0.0131 0.0138 0.0138
Onchocerca volvulus Neuropeptide F receptor homolog 0.0109 0.0111 0.0333
Loa Loa (eye worm) hypothetical protein 0.012 0.0125 0.0124
Brugia malayi Thioredoxin reductase 0.0047 0.0032 0.0032
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.005 0.0036 0.0036
Echinococcus granulosus hypothetical protein 0.0109 0.0111 0.011
Brugia malayi protein kinase C3,putative 0.0466 0.056 0.056
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.0044 1
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0112 0.0112
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus synaptic vesicular amine transporter 0.019 0.0213 0.0212
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0011 0.0368
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.0287 0.0287
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0097 0.0096 0.0095
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypoxia-induced factor 1 0.015 0.0162 0.0162
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0048 0.0034 0.0034
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0234 0.0267 0.0267
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0237 0.0272 0.0271
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0109 0.0111 0.011
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0222 0.0253 1
Schistosoma mansoni hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0159 0.0174 0.0173
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0109 0.0111 0.011
Brugia malayi G-protein coupled receptor 0.0109 0.0111 0.0111
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0237 0.0272 0.0271
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.0124 0.0124
Onchocerca volvulus 0.0026 0.0007 0.0019
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0109 0.0111 0.011
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0011 0.001
Brugia malayi hypoxia-induced factor 1 0.015 0.0162 0.0162
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0036 0.0036
Schistosoma mansoni neuropeptide f receptor 76f 0.0109 0.0111 0.011
Brugia malayi GnHR receptor homolog 0.0109 0.0111 0.0111
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0034 0.0045
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.002 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0248 0.0248
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0002 0.0002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0111 0.011
Echinococcus granulosus alpha 1A adrenergic receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Brugia malayi Cytochrome P450 family protein 0.0037 0.002 0.002
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0109 0.0111 0.011
Echinococcus multilocularis musashi 0.0026 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0287 0.9997
Schistosoma mansoni glutamate receptor kainate 0.0144 0.0155 0.0155
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0028 0.0009 0.0011
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus granulosus biogenic amine 5HT receptor 0.0109 0.0111 0.011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0036 0.0036
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0011 0.0011
Echinococcus multilocularis G-protein coupled receptor, putative 0.0109 0.0111 0.011
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0017 0.0017
Loa Loa (eye worm) norepinephrine transporter 0.0535 0.0647 0.0646
Brugia malayi sulfakinin receptor protein 0.0109 0.0111 0.0111
Onchocerca volvulus 0.0029 0.0011 0.003
Schistosoma mansoni ap endonuclease 0.0056 0.0044 0.0043
Trypanosoma cruzi C-8 sterol isomerase, putative 0.3974 0.4972 0.6646
Echinococcus granulosus allatostatin A receptor 0.0109 0.0111 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0237 0.0272 0.0271
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0023 0.0002 0.0002
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0212 0.024 0.024
Echinococcus granulosus lamin 0.0026 0.0007 0.0006
Trypanosoma brucei cAMP binding protein, putative 0.0026 0.0007 0.0008
Loa Loa (eye worm) hypothetical protein 0.1041 0.1283 0.1282
Trypanosoma brucei cytochrome P450, putative 0.0037 0.002 0.0026
Echinococcus granulosus intermediate filament protein 0.0026 0.0007 0.0006
Echinococcus multilocularis glutamate receptor 2 0.0106 0.0107 0.0106
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0011 0.001
Echinococcus granulosus glycine receptor subunit beta 0.005 0.0036 0.0036
Toxoplasma gondii hypothetical protein 0.0091 0.0088 0.0087
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.005 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0272 0.946
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0112 0.2161
Loa Loa (eye worm) hypothetical protein 0.0649 0.0789 0.0789
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0017 0.0585
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Leishmania major hypothetical protein, conserved 0.0021 0 0.0000000034972
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0111 0.011
Echinococcus multilocularis lamin 0.0026 0.0007 0.0006
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Echinococcus granulosus vesicular acetylcholine transporter 0.2661 0.332 0.332
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.0088 0.0087
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0112 0.3901
Echinococcus granulosus g protein coupled receptor 0.0109 0.0111 0.011
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0037 0.002 0.0019
Echinococcus granulosus 6 phosphofructokinase 0.011 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0366 0.0433 0.0433
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0109 0.0111 0.011
Toxoplasma gondii thioredoxin reductase 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.005 0.0036 0.0036
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Brugia malayi Protein kinase domain containing protein 0.025 0.0287 0.0287
Echinococcus multilocularis DNA topoisomerase 1 0.7972 1 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0109 0.0111 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0885 0.1087 0.1087
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Schistosoma mansoni hypothetical protein 0.0047 0.0032 0.0032
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0036 0.0036
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0058 0.0077
Brugia malayi phosphofructokinase 0.011 0.0112 0.0112
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.0112 0.9132
Onchocerca volvulus 0.0109 0.0111 0.0333
Mycobacterium ulcerans hypothetical protein 0.0035 0.0017 0.0805
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0091 0.0088 0.0088
Schistosoma mansoni glutamate receptor kainate 0.0144 0.0155 0.0155
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.005 0.0036 0.0036
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0107 0.403
Echinococcus granulosus glutamate receptor 2 0.0106 0.0107 0.0106
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0091 0.0088 0.0087
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0013
Schistosoma mansoni glutamate receptor NMDA 0.0237 0.0271 0.0271
Brugia malayi Serotonin receptor 0.0109 0.0111 0.0111
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.0287 0.0287
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0109 0.0111 0.011
Onchocerca volvulus 0.0109 0.0111 0.0333
Schistosoma mansoni inositol monophosphatase 0.0036 0.0018 0.0018
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0262 0.0262
Schistosoma mansoni DNA topoisomerase type I 0.7972 1 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0052 0.0051
Schistosoma mansoni lipoxygenase 0.0084 0.0079 0.0078
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) cytochrome P450 0.0028 0.0009 0.0008
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0032 0.0031
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0159 0.0174 0.0173
Echinococcus granulosus neuropeptide receptor 0.0109 0.0111 0.011
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0028 0.0009 0.0009
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0109 0.0111 0.011
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0058 0.0057
Schistosoma mansoni hypothetical protein 0.0212 0.024 0.024
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0058 0.0058
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0032 0.0032
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.019 0.0213 0.0212
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0219 0.0248 0.0248
Onchocerca volvulus 0.005 0.0036 0.0107
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0053 0.0041 0.004
Plasmodium falciparum amino acid transporter, putative 0.0091 0.0088 0.0087
Entamoeba histolytica hypothetical protein 0.0027 0.0007 0.013
Loa Loa (eye worm) hypothetical protein 0.0437 0.0523 0.0522
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0011 0.0011
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0262 0.0262
Plasmodium vivax hypothetical protein, conserved 0.0091 0.0088 0.0087
Onchocerca volvulus 0.0035 0.0017 0.0051
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0017 0.0017
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0237 0.0272 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Echinococcus granulosus neuropeptide FF receptor 2 0.0109 0.0111 0.011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Onchocerca volvulus 0.0026 0.0007 0.0019
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0111 0.011
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Onchocerca volvulus 0.0578 0.07 0.2107
Echinococcus multilocularis 0.0028 0.0009 0.0008
Brugia malayi putative neuropeptide receptor 0.0109 0.0111 0.0111
Loa Loa (eye worm) serotonin transporter b 0.0535 0.0647 0.0646
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0058 0.0077
Schistosoma mansoni alpha-1 adrenergic receptor 0.0109 0.0111 0.011
Plasmodium vivax amine transporter, putative 0.0091 0.0088 0.0087
Echinococcus multilocularis allatostatin A receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0034 0.0034
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0036 0.0036
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.059 0.0716 0.0715
Schistosoma mansoni lamin 0.0026 0.0007 0.0006
Schistosoma mansoni adenoreceptor 0.0109 0.0111 0.011
Trypanosoma cruzi DNA topoisomerase type IB small subunit, putative 0.2003 0.2493 0.3332
Echinococcus granulosus serine:threonine protein kinase N2 0.0421 0.0503 0.0502
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0011 0.0204
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Loa Loa (eye worm) hypothetical protein 0.0829 0.1016 0.1016
Brugia malayi 6-phosphofructokinase 0.011 0.0112 0.0112
Loa Loa (eye worm) GABA receptor subunit 0.0027 0.0007 0.0007
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0032 0.0031
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0011 0.001
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0111 0.011
Brugia malayi Cation transporter family protein 0.005 0.0036 0.0036
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0036 0.0036
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0111 0.011
Onchocerca volvulus 0.0035 0.0017 0.0051
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0011 0.0368
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0107 0.403
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.0009 0.0009
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0465 0.0558 0.0557
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0035 0.0017 0.0051
Schistosoma mansoni hypothetical protein 0.0068 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0907 0.1115 0.1114
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Schistosoma mansoni histamine h1 receptor 0.0109 0.0111 0.011
Brugia malayi Hr1 repeat family protein 0.0237 0.0272 0.0272
Onchocerca volvulus 0.005 0.0036 0.0107
Onchocerca volvulus 0.0234 0.0267 0.0804
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0111 0.011
Brugia malayi Cytochrome P450 family protein 0.0028 0.0009 0.0009
Schistosoma mansoni opsin-like receptor 0.0109 0.0111 0.011
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0111 0.011
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.005 0.0036 0.0036
Entamoeba histolytica recQ family helicase, putative 0.0022 0.0002 0.0025
Brugia malayi Pleckstrin Homology Domain 0.0224 0.0256 0.0256
Loa Loa (eye worm) acetylcholine receptor protein 0.0023 0.0002 0.0002
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0437 0.0523 0.0522
Schistosoma mansoni diacylglycerol kinase theta 0.0212 0.024 0.024
Brugia malayi Cation transporter family protein 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.3974 0.4972 0.4971
Echinococcus granulosus serine:threonine protein kinase N2 0.0237 0.0272 0.0271
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.0044 0.0043
Echinococcus multilocularis GPCR, family 2 0.0031 0.0013 0.0013
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0036 0.0036
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Echinococcus granulosus microtubule associated protein 2 0.069 0.0841 0.0841
Loa Loa (eye worm) hypothetical protein 0.0229 0.0262 0.0262
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.0044 0.0058
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0111 0.011
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0109 0.0111 0.011
Brugia malayi RhoGAP domain containing protein 0.0212 0.024 0.024
Toxoplasma gondii hypothetical protein 0.0091 0.0088 0.0087
Onchocerca volvulus 0.0023 0.0002 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.069 0.0841 0.0841
Brugia malayi RhoGAP domain containing protein 0.0212 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0032 0.0014 0.0013
Echinococcus multilocularis orexin receptor type 2 0.0109 0.0111 0.011
Onchocerca volvulus 0.012 0.0125 0.0374
Brugia malayi larval opioid receptor 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0829 0.1016 0.1016
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0091 0.0088 0.0087
Entamoeba histolytica protein kinase, putative 0.0237 0.0272 0.524
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.0044 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0272 0.946
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0111 0.011
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.005 0.0036 0.0036
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0087
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0091 0.0088 0.0087
Trypanosoma brucei C-14 sterol reductase, putative 0.0093 0.0091 0.0121
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0231 0.0264 0.9176
Onchocerca volvulus 0.0023 0.0002 0.0006
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0036 0.0036
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.0044 0.0058
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0011 0.0368
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0027 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0029 0.0011 0.001
Echinococcus multilocularis serine threonine protein kinase 0.0695 0.0848 0.0848
Schistosoma mansoni hypothetical protein 0.0996 0.1226 0.1226
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0237 0.0272 0.0271
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0087
Entamoeba histolytica protein kinase, putative 0.025 0.0287 0.554
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) RasGEF domain-containing protein 0.0212 0.024 0.024
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0017 0.0341
Schistosoma mansoni DNA topoisomerase type I 0.5969 0.7481 0.7481
Loa Loa (eye worm) latrophilin receptor protein 2 0.0031 0.0013 0.0013
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0058 0.0057
Leishmania major cytochrome p450-like protein 0.0028 0.0009 0.0011
Echinococcus granulosus g protein coupled receptor 0.0109 0.0111 0.011
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.0044 0.0058
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.0044 0.0043
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0013
Toxoplasma gondii cytochrome p450 superfamily protein 0.0028 0.0009 0.0008
Trypanosoma cruzi sterol C-24 reductase, putative 0.0048 0.0034 0.0045
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0219 0.0248 0.0248
Trichomonas vaginalis AGC family protein kinase 0.0237 0.0272 0.946
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0018 0.0024
Echinococcus multilocularis RNA directed DNA polymerase 0.0437 0.0523 0.0522
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0091 0.0088 1
Brugia malayi ORL1-like opioid receptor 0.0109 0.0111 0.0111
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0044 0.1506
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0032 0.0031
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.005 0.0036 0.0036
Loa Loa (eye worm) CYP4Cod1 0.0037 0.002 0.002
Echinococcus multilocularis serotonin transporter 0.0535 0.0647 0.0646
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0018 0.0624
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0107 0.403
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.002 0.0026
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0028 0.0009 0.0011
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0013
Echinococcus granulosus geminin 0.0996 0.1226 0.1226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.0212 0.024 0.024
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0053 0.0041 0.004
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni unc-13 (munc13) 0.0236 0.027 0.0269
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0287 0.9997
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0111 0.011
Trypanosoma cruzi DNA topoisomerase IB, large subunit, putative 0.5969 0.7481 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0018 0.0624
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0109 0.0111 0.011
Echinococcus multilocularis protein kinase c iota type 0.0697 0.085 0.085
Leishmania major DNA topoisomerase type IB small subunit 0.2003 0.2493 0.3332
Echinococcus multilocularis Rac GTPase activating protein 1 0.0212 0.024 0.024
Toxoplasma gondii AGC kinase 0.0237 0.0272 0.0271
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0017 0.0585
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0011 0.0368
Schistosoma mansoni vav2 0.0224 0.0256 0.0255
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.0044 0.0044
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0017 0.0017
Echinococcus granulosus sodium and chloride dependent glycine 0.0091 0.0088 0.0087
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0011 0.0368
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0052 0.0051
Echinococcus multilocularis sodium and chloride dependent glycine 0.0091 0.0088 0.0087
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0058 0.0057
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.0112 0.0112
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.0044 0.0514
Echinococcus granulosus 7TM GPCR rhodopsin 0.0109 0.0111 0.011
Schistosoma mansoni voltage-gated potassium channel 0.004 0.0024 0.0024
Toxoplasma gondii diacylglycerol kinase, putative 0.0212 0.024 0.024
Brugia malayi Ras association domain family 1 isoform A 0.0212 0.024 0.024
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0009 0.0008
Onchocerca volvulus 0.0109 0.0111 0.0333
Entamoeba histolytica diacylglycerol kinase, putative 0.0212 0.024 0.4631
Schistosoma mansoni glutamate receptor kainate 0.0144 0.0155 0.0155
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0122 0.4642
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0212 0.024 0.024
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0006 0.0005
Echinococcus granulosus glutamate receptor 2 0.0159 0.0174 0.0173
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0036 0.0036
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.005 0.0036 0.0036
Onchocerca volvulus 0.0036 0.0019 0.0055
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0091 0.0121
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0109 0.0111 0.011
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0034 0.0016 0.0015
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.005 0.0036 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0032 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0006 0.0005
Brugia malayi PAS domain containing protein 0.0048 0.0034 0.0034
Schistosoma mansoni neuropeptide receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0088
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0111 0.011
Schistosoma mansoni DNA topoisomerase type I 0.5969 0.7481 0.7481
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0109 0.0111 0.011
Schistosoma mansoni atypical protein kinase C 0.0715 0.0873 0.0873
Mycobacterium tuberculosis Conserved protein 0.0035 0.0017 0.0341
Brugia malayi putative neuropeptide receptor NPR1 0.0109 0.0111 0.0111
Echinococcus multilocularis geminin 0.0996 0.1226 0.1226
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0234 0.0267 0.0267
Echinococcus granulosus neuropeptide s receptor 0.0109 0.0111 0.011
Leishmania major DNA topoisomerase IB, large subunit 0.5969 0.7481 1
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Schistosoma mansoni intracisternal A-particle retropepsin (A02 family) 0.1528 0.1895 0.1895
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0018 0.0024
Brugia malayi intermediate filament protein 0.0026 0.0007 0.0007
Brugia malayi Protein kinase domain containing protein 0.0025 0.0004 0.0004
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0111 0.011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0109 0.0111 0.011
Schistosoma mansoni diacylglycerol kinase theta 0.0212 0.024 0.024
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0112 0.0112
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0112 0.3901
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0535 0.0647 0.0646
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0052 0.0051
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0237 0.0272 0.0271
Mycobacterium leprae Probable lipase LipE 0.0035 0.0017 0.0735
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0112 0.3901
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0021 0 0.000000091176
Brugia malayi RhoGEF domain containing protein 0.0212 0.024 0.024
Brugia malayi hypothetical protein 0.0091 0.0088 0.0088
Echinococcus granulosus glutamate receptor NMDA 0.0077 0.0071 0.007
Schistosoma mansoni nAChR subunit 0.0023 0.0002 0.0002
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0011 0.0011
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0907 0.1115 0.1114
Loa Loa (eye worm) vesicular acetylcholine transporter unc-17 0.2661 0.332 0.332
Brugia malayi AKH receptor 0.0109 0.0111 0.0111
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0036 0.0036
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0018 0.0346
Brugia malayi Abnormal catecholamine distribution protein 1 0.019 0.0213 0.0213
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0052 0.0051
Schistosoma mansoni lipoxygenase 0.012 0.0124 0.0124
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0011 0.0011
Echinococcus multilocularis lamin b receptor 0.0093 0.0091 0.009
Echinococcus multilocularis sex peptide receptor 0.0109 0.0111 0.011
Mycobacterium tuberculosis Conserved protein 0.0035 0.0017 0.0341
Schistosoma mansoni inositol monophosphatase 0.0036 0.0018 0.0018
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.0068 0.0067
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.276 0.3445 0.3445
Schistosoma mansoni single-minded 0.0048 0.0034 0.0034
Trichomonas vaginalis ion channel nompc, putative 0.0021 0 0.000000091176
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.005 0.0036 0.0036
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0011 0.001
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0018 0.0024
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0025 0.0004 0.0012
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Onchocerca volvulus 0.0234 0.0267 0.0804
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0111 0.011
Trypanosoma cruzi cAMP binding protein, putative 0.0026 0.0007 0.0008
Loa Loa (eye worm) AGC/NDR protein kinase 0.0237 0.0272 0.0271
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0027 0.0007 0.0007
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0017 0.0735
Loa Loa (eye worm) glutathione reductase 0.0047 0.0032 0.0032
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0007 0.0006
Onchocerca volvulus Putative nachr subunit 0.005 0.0036 0.0107
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0032 0.0031
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Trypanosoma cruzi C-14 sterol reductase, putative 0.0093 0.0091 0.0121
Brugia malayi Dopamine receptor 0.0109 0.0111 0.0111
Echinococcus granulosus tm gpcr rhodopsin 0.0109 0.0111 0.011
Toxoplasma gondii exonuclease III APE 0.0056 0.0044 0.0043
Echinococcus granulosus RNA directed DNA polymerase 0.0437 0.0523 0.0522
Echinococcus granulosus sex peptide receptor 0.0109 0.0111 0.011
Brugia malayi RNA binding protein 0.0062 0.0052 0.0052
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0011 0.001
Schistosoma mansoni neurotransmitter gated ion channel 0.0027 0.0007 0.0007
Onchocerca volvulus 0.0109 0.0111 0.0333
Loa Loa (eye worm) hypothetical protein 0.0944 0.1161 0.116
Schistosoma mansoni protein kinase C mu 0.0584 0.0708 0.0708
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) AGC/AKT protein kinase 0.025 0.0287 0.0287
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0023 0.0002 0.0002
Brugia malayi Melatonin receptor type 1A 0.0109 0.0111 0.0111
Echinococcus multilocularis unc 13 (munc13) 0.0234 0.0267 0.0267
Schistosoma mansoni myosin xvIII 0.0109 0.0111 0.011
Onchocerca volvulus 0.0023 0.0002 0.0006
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus Diacylglycerol kinase theta 0.0212 0.024 0.024
Echinococcus multilocularis vesicular acetylcholine transporter 0.2661 0.332 0.332
Brugia malayi ERG2 and Sigma1 receptor like protein 0.3974 0.4972 0.4972
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0212 0.024 0.024
Brugia malayi Variant SH3 domain containing protein 0.0212 0.024 0.024
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.0044 0.0058
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0032 0.0952
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0006 0.0005
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0017 0.0017
Trichomonas vaginalis esterase, putative 0.0035 0.0017 0.0585
Brugia malayi latrophilin 2 splice variant baaae 0.0068 0.0059 0.0059
Schistosoma mansoni serine/threonine protein kinase 0.0219 0.0248 0.0248
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0011 0.0011
Echinococcus multilocularis raf serine:threonine protein kinase 0.0212 0.024 0.024
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.0112 0.1594
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0018 0.0018
Schistosoma mansoni amine GPCR 0.0109 0.0111 0.011
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0036 0.0036
Schistosoma mansoni amine GPCR 0.0109 0.0111 0.011
Echinococcus granulosus nAChR subunit 0.0027 0.0007 0.0007
Schistosoma mansoni serine/threonine protein kinase 0.0907 0.1115 0.1114
Echinococcus multilocularis neuropeptide receptor 0.0109 0.0111 0.011
Trichomonas vaginalis DNA helicase recq, putative 0.0042 0.0026 0.0903
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus granulosus Protein kinase C brain isozyme 0.0907 0.1115 0.1114
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0031 0.0013 0.0013
Entamoeba histolytica hypothetical protein 0.0212 0.024 0.4631
Brugia malayi Protein kinase domain containing protein 0.0237 0.0272 0.0272
Loa Loa (eye worm) beta-lactamase 0.0035 0.0017 0.0017
Onchocerca volvulus 0.0091 0.0088 0.0263
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0017 0.0017
Echinococcus granulosus orexin receptor type 2 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni serine/threonine protein kinase 0.0237 0.0272 0.0271
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Schistosoma mansoni protein kinase C mu 0.0212 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0122 0.4642
Leishmania major hypothetical protein, conserved 0.0026 0.0007 0.0008
Onchocerca volvulus 0.0109 0.0111 0.0333
Brugia malayi neuropeptide F receptor 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0109 0.0111 0.011
Schistosoma mansoni survival motor neuron protein 0.0047 0.0032 0.0032
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Leishmania major C-8 sterol isomerase-like protein 0.3974 0.4972 0.6646
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0032 0.0031
Brugia malayi diacylglycerol kinase 0.0212 0.024 0.024
Loa Loa (eye worm) neuropeptide F receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) AGC/PKN protein kinase 0.0237 0.0272 0.0271
Onchocerca volvulus 0.0109 0.0111 0.0333
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Trypanosoma brucei trypanothione reductase 0.0047 0.0032 0.0042
Onchocerca volvulus 0.0366 0.0433 0.1304
Echinococcus multilocularis g-protein coupled receptor 0.0109 0.0111 0.011
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0011 0.001
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0109 0.0111 0.0111
Schistosoma mansoni biogenic amine receptor 0.0109 0.0111 0.011
Schistosoma mansoni acetylcholine receptor-related 0.0023 0.0002 0.0002
Echinococcus multilocularis glutamate receptor NMDA 0.0077 0.0071 0.007
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0885 0.1087 0.1087
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.019 0.6622
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0058 0.0077
Brugia malayi protein kinase C II. 0.0885 0.1087 0.1087
Echinococcus multilocularis g protein coupled receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) melatonin receptor type 1A 0.0109 0.0111 0.011
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.005 0.0036 0.0036
Brugia malayi Calcitonin receptor-like protein seb-1 0.0099 0.0098 0.0098
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0036 0.0036
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0109 0.0111 0.011
Brugia malayi Protein kinase domain containing protein 0.0237 0.0272 0.0272
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0017 0.0585
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0212 0.024 0.024
Toxoplasma gondii DNA topoisomerase I, putative 0.7972 1 1
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.0112 1
Trypanosoma cruzi cytochrome P450, putative 0.0037 0.002 0.0026
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0287 0.9997
Echinococcus multilocularis myotubularin protein 13 0.0224 0.0256 0.0255
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0052 0.0051
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus granulosus g-protein coupled receptor 0.0109 0.0111 0.011
Echinococcus granulosus dro:myosuppressin receptor 0.0109 0.0111 0.011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0017 0.0571
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0017 0.0571
Echinococcus multilocularis somatostatin receptor 0.0109 0.0111 0.011
Brugia malayi hypothetical protein 0.0163 0.0178 0.0178
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0017 0.0022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0017 0.0805
Loa Loa (eye worm) hypothetical protein 0.0163 0.0178 0.0178
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0535 0.0647 0.0647
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus peptide allatostatin:somatostatin 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0052 0.0051
Echinococcus multilocularis neuropeptides capa receptor 0.0109 0.0111 0.011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0032 0.0032
Schistosoma mansoni hypothetical protein 0.0028 0.0009 0.0008
Schistosoma mansoni acetylcholine receptor subunit beta 0.0023 0.0002 0.0002
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0099 0.0098 0.0098
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0036 0.0036
Loa Loa (eye worm) RecQ helicase 0.0042 0.0026 0.0026
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0017 0.0022
Schistosoma mansoni ap endonuclease 0.0056 0.0044 0.0043
Onchocerca volvulus 0.0829 0.1016 0.3059
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0237 0.0272 0.0271
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus granulosus nmda type glutamate receptor 0.0092 0.009 0.0089
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0022 0.0022
Brugia malayi RE15519p 0.0109 0.0111 0.0111
Echinococcus granulosus N chimaerin 0.0212 0.024 0.024
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0159 0.0174 0.0173
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0052 0.0051
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Schistosoma mansoni hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) ACC-1 protein 0.005 0.0036 0.0036
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0058 0.0057
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Plasmodium falciparum thioredoxin reductase 0.0047 0.0032 0.0032
Onchocerca volvulus 0.0091 0.0088 0.0263
Loa Loa (eye worm) hypothetical protein 0.0212 0.024 0.024
Onchocerca volvulus 0.0109 0.0111 0.0333
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.0044 0.1506
Echinococcus granulosus myotubularin protein 13 0.0224 0.0256 0.0255
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0484 0.0583 0.0582
Schistosoma mansoni ATP-binding cassette transporter 0.0144 0.0155 0.0155
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.0088 0.0087
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0088
Echinococcus multilocularis nmda type glutamate receptor 0.0092 0.009 0.0089
Brugia malayi excitatory GABA receptor EXP-1A 0.005 0.0036 0.0036
Echinococcus multilocularis sodium and chloride dependent glycine 0.0091 0.0088 0.0087
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0022 0.0022
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0028 0.0009 0.0011
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0109 0.0111 0.011
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0287 0.9997
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.002 0.002
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0032 0.0032
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0018 0.0624
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0022 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0212 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0058 0.1108
Echinococcus multilocularis neuropeptide receptor A26 0.0109 0.0111 0.011
Brugia malayi G protein-coupled receptor F59B2.13 0.0109 0.0111 0.0111
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0109 0.0111 0.011
Schistosoma mansoni vesicular amine transporter 0.019 0.0213 0.0212
Loa Loa (eye worm) ACC-1 protein 0.005 0.0036 0.0036
Leishmania major trypanothione reductase 0.0047 0.0032 0.0042
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0002 0.0002
Echinococcus granulosus cytochrome P450 2K1 0.0028 0.0009 0.0008
Toxoplasma gondii ABC1 family protein 0.0035 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.2031 0.2528 0.2528
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus granulosus single minded 2 0.0039 0.0023 0.0022
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0107 0.403
Loa Loa (eye worm) glutamate receptor 2 0.0144 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0944 0.1161 0.116
Loa Loa (eye worm) G-protein coupled receptor 0.0109 0.0111 0.011
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0109 0.0111 0.0111
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0014 0.042
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Loa Loa (eye worm) hypothetical protein 0.0099 0.0098 0.0098
Brugia malayi Bloom's syndrome protein homolog 0.0042 0.0026 0.0026
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0087
Entamoeba histolytica phosphofructokinase, putative 0.011 0.0112 0.2161
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.0044 0.1425
Schistosoma mansoni microtubule-associated protein tau 0.069 0.0841 0.0841
Loa Loa (eye worm) RNA binding protein 0.0062 0.0052 0.0051
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.0112 0.4239
Mycobacterium ulcerans beta-lactamase 0.0035 0.0017 0.0805
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0017 0.0341
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0112 0.015
Echinococcus granulosus protein kinase C gamma type 0.0695 0.0848 0.0848
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0023 0.0002 0.0002
Schistosoma mansoni nAChR subunit 0.0023 0.0002 0.0002
Echinococcus granulosus glutamate receptor subunit protein glur 0.0053 0.0041 0.004
Loa Loa (eye worm) phosphofructokinase 0.011 0.0112 0.0112
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.0044 0.0043
Loa Loa (eye worm) raf kinase 0.0212 0.024 0.024
Schistosoma mansoni amine GPCR 0.0109 0.0111 0.011
Schistosoma mansoni cytochrome P450 0.0028 0.0009 0.0008
Echinococcus multilocularis Diacylglycerol kinase theta 0.0212 0.024 0.024
Echinococcus granulosus nAChR subunit 0.005 0.0036 0.0036
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0159 0.0174 0.0173
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.005 0.0036 0.0036
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0011 0.001
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0006 0.0007
Echinococcus multilocularis neuropeptide Y receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0566 0.0685 0.0685
Schistosoma mansoni 6-phosphofructokinase 0.011 0.0112 0.0112
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0099 0.0098 0.0098
Entamoeba histolytica PH domain containing protein kinase, putative 0.0433 0.0518 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0002 0.0002
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Brugia malayi glutathione reductase 0.0047 0.0032 0.0032
Echinococcus granulosus somatostatin receptor 0.0109 0.0111 0.011
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0027 0.0007 0.0007
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0017 0.0585
Brugia malayi hypothetical protein 0.0229 0.0262 0.0262
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.0112 0.3901
Schistosoma mansoni sodium-dependent amino acid transporter 0.0091 0.0088 0.0087
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0017 0.0022
Loa Loa (eye worm) TYRA-2 protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Echinococcus granulosus serotonin receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0053 0.0041 0.004
Brugia malayi Dopamine receptor protein 1 0.0109 0.0111 0.0111
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0179 0.0539
Brugia malayi cytochrome P450 0.0028 0.0009 0.0009
Echinococcus multilocularis serine:threonine protein kinase N2 0.0652 0.0793 0.0793
Brugia malayi Cytochrome P450 family protein 0.0028 0.0009 0.0009
Brugia malayi Glutamate receptor 2 precursor 0.0144 0.0155 0.0155
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.0287 0.9997
Loa Loa (eye worm) hypothetical protein 0.0091 0.0088 0.0087
Brugia malayi diacylglycerol kinase 0.0212 0.024 0.024
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0088
Loa Loa (eye worm) hypothetical protein 0.0578 0.07 0.07
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0031 0.0013 0.0013
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Schistosoma mansoni amine GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0212 0.024 0.024
Echinococcus multilocularis nAChR subunit 0.0027 0.0007 0.0007
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0107 0.8682
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0017 0.0341
Echinococcus granulosus glycine receptor subunit alpha 1 0.005 0.0036 0.0036
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.005 0.0036 0.0036
Brugia malayi TAR-binding protein 0.0062 0.0052 0.0052
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0037 0.002 0.002
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Echinococcus multilocularis glutamate receptor 2 0.0159 0.0174 0.0173
Echinococcus granulosus lamin b receptor 0.0093 0.0091 0.009
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0032 0.0032
Echinococcus granulosus protein kinase c epsilon type 0.0885 0.1087 0.1087
Leishmania major sterol C-24 reductase, putative 0.0048 0.0034 0.0045
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Trypanosoma brucei rac serine-threonine kinase, putative 0.025 0.0287 0.0384
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0109 0.0111 0.011
Echinococcus multilocularis serine:threonine protein kinase 38 0.0237 0.0272 0.0271
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0007 0.0006
Echinococcus multilocularis glycine receptor subunit beta 0.005 0.0036 0.0036
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.0112 0.015
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.1066 0.1314 0.1314
Leishmania major protein kinase, putative 0.0024 0.0004 0.0004
Trypanosoma cruzi C2 domain/Ankyrin repeats (3 copies), putative 0.0021 0 0.0000000034972
Schistosoma mansoni serine/threonine kinase 0.0237 0.0272 0.0271
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0023 0.0002 0.0002
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0237 0.0272 0.0271
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0109 0.0111 0.011
Echinococcus granulosus tar DNA binding protein 0.0062 0.0052 0.0051
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0159 0.0174 0.0173
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.005 0.0036 0.0036
Trypanosoma brucei DNA topoisomerase type IB small subunit 0.2003 0.2493 0.3332
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0031 0.0013 0.0013
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.005 0.0036 0.0036
Schistosoma mansoni nAChR subunit 0.005 0.0036 0.0036
Onchocerca volvulus 0.0027 0.0007 0.002
Brugia malayi hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Trypanosoma brucei C-8 sterol isomerase, putative 0.3974 0.4972 0.6646
Leishmania major C-14 sterol reductase, putative 0.0093 0.0091 0.0121
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus raf serine:threonine protein kinase 0.0212 0.024 0.024
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0535 0.0647 0.0646
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0023 0.0002 0.0002
Schistosoma mansoni rac gtpase activating protein 0.0212 0.024 0.024
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.005 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0026 0.0006 0.0005
Echinococcus multilocularis bloom syndrome protein 0.0042 0.0026 0.0026
Echinococcus granulosus tm gpcr rhodopsin 0.276 0.3445 0.3445
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni neuropeptide F-like receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0091 0.0088 0.0087
Onchocerca volvulus 0.012 0.0125 0.0374
Brugia malayi Inositol-1 0.0036 0.0018 0.0018
Schistosoma mansoni opsin-like receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0237 0.0272 0.0271
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0159 0.0174 0.0173
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Onchocerca volvulus 0.0535 0.0647 0.1947
Loa Loa (eye worm) inositol-1 0.0036 0.0018 0.0018
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.0044 0.0043
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Schistosoma mansoni biogenic amine (5HT) receptor 0.0109 0.0111 0.011
Brugia malayi 6-phosphofructokinase 0.011 0.0112 0.0112
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Entamoeba histolytica protein kinase, putative 0.0028 0.0009 0.0157
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0034 0.0016 0.0015
Echinococcus multilocularis glutamate receptor 2 0.0144 0.0155 0.0155
Schistosoma mansoni glutamate receptor NMDA 0.0307 0.0359 0.0359
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0053 0.0041 0.004
Onchocerca volvulus 0.0047 0.0032 0.0096
Trypanosoma brucei DNA topoisomerase IB, large subunit 0.5969 0.7481 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0212 0.024 0.024
Onchocerca volvulus 0.0027 0.0007 0.002
Brugia malayi Pre-SET motif family protein 0.0205 0.0232 0.0232
Echinococcus multilocularis nmda type glutamate receptor 0.0131 0.0138 0.0138
Brugia malayi follicle stimulating hormone receptor 0.0566 0.0685 0.0685
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Echinococcus multilocularis dro:myosuppressin receptor 0.0109 0.0111 0.011
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0017 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0017 0.0585
Schistosoma mansoni hypothetical protein 0.0996 0.1226 0.1226
Echinococcus multilocularis N chimaerin 0.0212 0.024 0.024
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0058 0.0077
Leishmania major hypothetical protein, conserved 0.0026 0.0006 0.0007
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0159 0.0174 0.0173
Brugia malayi Glutamate receptor 1 precursor 0.0144 0.0155 0.0155
Onchocerca volvulus 0.059 0.0716 0.2154
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0009 0.0011
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0025 0.0004 0.0004
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0234 0.0267 0.0267
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0109 0.0111 0.011
Entamoeba histolytica protein kinase, putative 0.0028 0.0009 0.0157
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0023 0.0002 0.0002
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0031 0.0013 0.0013
Onchocerca volvulus 0.0091 0.0088 0.0263
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0014 0.0195
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0018 0.0024
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0366 0.0433 0.0433
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0028 0.0009 0.0011
Schistosoma mansoni amine GPCR 0.0109 0.0111 0.011
Brugia malayi beta-lactamase family protein 0.0035 0.0017 0.0017
Echinococcus granulosus fmrfamide receptor 0.0109 0.0111 0.011
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0007
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.0112 0.0112
Brugia malayi p70 ribosomal S6 kinase beta 0.0237 0.0272 0.0272
Echinococcus granulosus neuropeptides capa receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Brugia malayi Cation transporter family protein 0.012 0.0125 0.0125
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.0044 0.336
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0109 0.0111 0.011
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.005 0.0036 0.0036
Trichomonas vaginalis AGC family protein kinase 0.025 0.0287 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0122 0.4642
Brugia malayi Cytochrome P450 family protein 0.0037 0.002 0.002
Onchocerca volvulus 0.005 0.0036 0.0107
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0011 0.0011
Schistosoma mansoni biogenic amine receptor 0.0109 0.0111 0.011
Onchocerca volvulus 0.0109 0.0111 0.0333
Loa Loa (eye worm) hypothetical protein 0.0212 0.024 0.024
Echinococcus multilocularis fmrfamide receptor 0.0109 0.0111 0.011
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0109 0.0111 0.011
Schistosoma mansoni sodium/chloride dependent transporter 0.0097 0.0096 0.0095
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0017 0.0341
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0023 0.0002 0.0002
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0212 0.024 0.024
Plasmodium vivax SET domain protein, putative 0.0029 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.005 0.0036 0.0036
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.012 0.0125 0.0124
Loa Loa (eye worm) glutamate receptor 1 0.0144 0.0155 0.0155
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0109 0.0111 0.011
Plasmodium falciparum topoisomerase I 0.7972 1 1
Echinococcus multilocularis serotonin receptor 0.0109 0.0111 0.011
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.005 0.0036 0.0036
Treponema pallidum sodium- and chloride- dependent transporter 0.0535 0.0647 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0002 0.0002
Brugia malayi beta-lactamase 0.0035 0.0017 0.0017
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Echinococcus granulosus neuropeptide Y receptor 0.0109 0.0111 0.011
Schistosoma mansoni glutamate receptor AMPA 0.0144 0.0155 0.0155
Schistosoma mansoni intermediate filament proteins 0.0026 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0053 0.0041 0.004
Brugia malayi Tachykinin-like peptides receptor 99D 0.0109 0.0111 0.0111
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0091 0.0088 0.0087
Schistosoma mansoni sodium/chloride dependent transporter 0.0535 0.0647 0.0646
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0109 0.0111 0.0333
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0032 0.0032
Loa Loa (eye worm) hypothetical protein 0.0035 0.0017 0.0017
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.0044 0.0834
Echinococcus granulosus NDR protein kinase 0.0237 0.0272 0.0271
Brugia malayi Protein kinase domain containing protein 0.0219 0.0248 0.0248
Echinococcus granulosus rhodopsin orphan GPCR 0.0109 0.0111 0.011
Echinococcus multilocularis glycine receptor subunit alpha 1 0.005 0.0036 0.0036
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0027 0.0007 0.0007
Plasmodium falciparum transporter, putative 0.0091 0.0088 0.0087
Brugia malayi beta-lactamase family protein 0.0035 0.0017 0.0017
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0109 0.0111 0.011
Schistosoma mansoni growth hormone secretagogue receptor 0.0109 0.0111 0.011
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.005 0.0036 0.0036
Schistosoma mansoni blooms syndrome DNA helicase 0.0033 0.0015 0.0015
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0023 0.0002 0.0002
Echinococcus granulosus G protein coupled receptor 139 0.0109 0.0111 0.011
Schistosoma mansoni vesicular acetylcholine transporter 0.2661 0.332 0.332
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0091 0.0088 0.0087
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0179 0.6236
Echinococcus granulosus glutamate NMDA receptor subunit 0.0307 0.0359 0.0359
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0053 0.0041 0.004
Onchocerca volvulus 0.0109 0.0111 0.0333
Echinococcus granulosus g protein coupled receptor 0.0109 0.0111 0.011
Echinococcus granulosus 7tm_1 domain containing protein 0.0109 0.0111 0.011
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.0124 0.0124
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0109 0.0111 0.011
Loa Loa (eye worm) hypothetical protein 0.0109 0.0111 0.011
Entamoeba histolytica diacylglycerol kinase, putative 0.0212 0.024 0.4631
Schistosoma mansoni glutamate receptor AMPA 0.0144 0.0155 0.0155
Schistosoma mansoni neuropeptide receptor 0.0109 0.0111 0.011
Brugia malayi hypothetical protein 0.0109 0.0111 0.0111
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0017 0.0341
Trichomonas vaginalis DNA helicase recq, putative 0.0022 0.0002 0.0044
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.012 0.0125 0.0124
Echinococcus multilocularis rhodopsin orphan GPCR 0.0109 0.0111 0.011
Loa Loa (eye worm) DNA topoisomerase I 0.7972 1 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1.8 uM Inhibitory activity against HIV-1 protease ChEMBL. 14505679
IC50 (binding) = 1.8 uM Inhibitory activity against HIV-1 protease ChEMBL. 14505679

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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