Detailed information for compound 24660

Basic information

Technical information
  • TDR Targets ID: 24660
  • Name: 3-(diaminomethylideneamino)octanoic acid
  • MW: 201.266 | Formula: C9H19N3O2
  • H donors: 3 H acceptors: 2 LogP: 0.55 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCC(N=C(N)N)CC(=O)O
  • InChi: 1S/C9H19N3O2/c1-2-3-4-5-7(6-8(13)14)12-9(10)11/h7H,2-6H2,1H3,(H,13,14)(H4,10,11,12)
  • InChiKey: CDXONOVKDVPSCE-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-guanidinooctanoic acid
  • 3-[bis(azanyl)methylideneamino]octanoic acid
  • 3-guanidinocaprylic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei carbonic anhydrase-like protein 0.0355 0.3866 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0058 0.0457 0.0741
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0108 0.1029 0.1029
Schistosoma mansoni memapsin-2 (A01 family) 0.0467 0.5158 0.5158
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0022 0.0037 0.0096
Schistosoma mansoni nuclear hormone receptor 0.0108 0.1029 0.1029
Echinococcus multilocularis dna polymerase kappa 0.0043 0.0282 0.0282
Leishmania major glycerol uptake protein, putative 0.0021 0.0022 0.0058
Brugia malayi intermediate filament protein 0.0087 0.0785 0.095
Leishmania major glycerol uptake protein, putative 0.0021 0.0022 0.0058
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0161 0.0417
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0238 0.252 0.252
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0851 0.0851
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.013 0.1276 0.1276
Loa Loa (eye worm) carboxylesterase 0.0345 0.376 0.4552
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.0028 0.0072
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0028 0.0034
Loa Loa (eye worm) hypothetical protein 0.013 0.1276 0.1545
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0149 0.1498 0.8345
Schistosoma mansoni carbonic anhydrase-related 0.0132 0.13 0.13
Brugia malayi tailless protein 0.0108 0.1029 0.1247
Brugia malayi nuclear hormone receptor 0.0238 0.252 0.3051
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.0375 0.097
Onchocerca volvulus Protein ultraspiracle homolog 0.0238 0.252 0.4089
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0037 0.0304
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0149 0.1498 0.8345
Schistosoma mansoni lamin 0.0087 0.0785 0.0785
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0144 0.1441 0.3727
Schistosoma mansoni nuclear receptor 0.0108 0.1029 0.1029
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0019 0.0001 0.0008
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.012 0.1164 0.1164
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0047 0.0328 0.0532
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0065 0.0533 0.0533
Schistosoma mansoni intermediate filament proteins 0.0087 0.0785 0.0785
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0221 0.0221
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0125 0.1223 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0007 0.0007
Echinococcus granulosus axis inhibition protein axin 0.002 0.0017 0.0017
Plasmodium falciparum geranylgeranyltransferase, putative 0.0021 0.0028 0.0206
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0149 0.1498 0.8345
Loa Loa (eye worm) hypothetical protein 0.0554 0.6162 0.7462
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.0375 0.097
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0125 0.1223 0.3163
Brugia malayi regulator of G-protein signaling egl-10 0.002 0.0017 0.0021
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0149 0.1498 0.8345
Brugia malayi nuclear receptor RXR 0.013 0.1276 0.1545
Schistosoma mansoni sterol O-acyltransferase 1 0.0211 0.2214 0.2214
Schistosoma mansoni carbonic anhydrase-related 0.0132 0.13 0.13
Trichomonas vaginalis conserved hypothetical protein 0.0125 0.1223 1
Brugia malayi nuclear receptor RXR 0.0108 0.1029 0.1247
Echinococcus multilocularis musashi 0.0087 0.0785 0.0785
Schistosoma mansoni cytochrome P450 0.0019 0.0005 0.0005
Echinococcus granulosus carbonic anhydrase 0.0132 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0022 0.0037 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0238 0.252 0.3051
Brugia malayi hypothetical protein 0.0038 0.0221 0.0267
Brugia malayi Calcitonin receptor-like protein seb-1 0.0157 0.1592 0.1927
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0037 0.0278
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0375 0.097
Brugia malayi CHE-14 protein 0.0104 0.0978 0.1184
Brugia malayi MBOAT family protein 0.0021 0.0022 0.0027
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0357 0.0357
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0132 0.13 0.1575
Toxoplasma gondii DNA topoisomerase 2, putative 0.0065 0.0533 0.4098
Mycobacterium ulcerans hydroxymethylglutaryl-coenzyme a (HMG-CoA) reductase 0.0144 0.1441 0.8023
Brugia malayi nuclear hormone receptor family member odr-7 0.0108 0.1029 0.1247
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0082
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0164 0.1677 0.1677
Echinococcus multilocularis expressed protein 0.0393 0.4302 0.4302
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.014
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Echinococcus granulosus neurogenic locus notch protein 0.005 0.0358 0.0358
Schistosoma mansoni nuclear hormone receptor 0.0108 0.1029 0.1029
Schistosoma mansoni retinoic acid receptor RXR 0.0238 0.252 0.252
Mycobacterium tuberculosis Probable oxidoreductase 0.013 0.1278 0.7115
Plasmodium vivax diacylglycerol O-acyltransferase, putative 0.0021 0.0022 0.0402
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0175 0.1795 0.4642
Echinococcus multilocularis BC026374 protein (S09 family) 0.0058 0.0457 0.0457
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.0028 0.0028
Schistosoma mansoni cpg binding protein 0.0066 0.0543 0.0543
Echinococcus multilocularis transcription factor Dp 1 0.004 0.0248 0.0248
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0108 0.1029 0.1029
Schistosoma mansoni hypothetical protein 0.005 0.0357 0.0357
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0282 0.073
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0028 0.0072
Plasmodium vivax geranylgeranyltransferase, putative 0.0021 0.0028 0.0503
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1261 0.1261
Echinococcus multilocularis 0.0019 0.0005 0.0005
Schistosoma mansoni thyroid hormone receptor 0.0384 0.4206 0.4206
Echinococcus multilocularis protein patched 0.0104 0.0978 0.0978
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0108 0.1029 0.1247
Echinococcus granulosus lamin 0.0087 0.0785 0.0785
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0108 0.1029 0.1029
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0021 0.0028 0.0503
Schistosoma mansoni lipoxygenase 0.0043 0.0278 0.0278
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0357 0.0432
Echinococcus multilocularis sterol regulatory element binding protein 0.0104 0.0978 0.0978
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0028 0.0034
Entamoeba histolytica DNA topoisomerase II, putative 0.0065 0.0533 0.4363
Loa Loa (eye worm) nuclear hormone receptor 0.0108 0.1029 0.1247
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0737 0.8259 0.8259
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0042 0.0268 0.0268
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0238 0.252 0.4089
Echinococcus granulosus carbonic anhydrase 0.0132 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.013 0.1276 0.1545
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0584 0.0584
Loa Loa (eye worm) hhat protein 0.0021 0.0022 0.0027
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0278 0.0278
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.0375 0.2879
Echinococcus granulosus ecdysone induced protein 78C 0.0238 0.252 0.252
Echinococcus granulosus pikachurin 0.005 0.0358 0.0358
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0007 0.0007
Brugia malayi Nuclear hormone receptor-like 1 0.013 0.1276 0.1545
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0238 0.252 0.3051
Echinococcus granulosus axis inhibition protein axin 0.002 0.0017 0.0017
Echinococcus granulosus geranylgeranyl transferase type I beta subunit 0.0021 0.0028 0.0028
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0147 0.1472 0.1472
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.004 0.0195
Echinococcus granulosus carbonic anhydrase 0.0132 0.13 0.13
Brugia malayi regulator of G-protein signaling rgs-7 0.002 0.0017 0.0021
Echinococcus granulosus geminin 0.0719 0.8058 0.8058
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0355 0.3866 0.3866
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0132 0.13 0.1575
Echinococcus multilocularis protein dispatched 1 0.011 0.105 0.105
Loa Loa (eye worm) hypothetical protein 0.0345 0.376 0.4552
Brugia malayi MBOAT family protein 0.0021 0.0022 0.0027
Schistosoma mansoni coup transcription factor 0.0238 0.252 0.252
Schistosoma mansoni hypothetical protein 0.005 0.0357 0.0357
Schistosoma mansoni zinc finger protein 0.0108 0.1029 0.1029
Loa Loa (eye worm) nuclear receptor NHR-67 0.0108 0.1029 0.1247
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0584 0.1511
Brugia malayi nuclear receptor NHR-88 0.0238 0.252 0.3051
Trichomonas vaginalis porcupine, putative 0.0021 0.0022 0.0183
Loa Loa (eye worm) abnormal epIthelia family member 0.005 0.0358 0.0434
Echinococcus multilocularis Membrane bound O acyl transferase, MBOAT 0.0021 0.0022 0.0022
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0017 0.0017
Loa Loa (eye worm) cytochrome P450 0.0019 0.0005 0.0006
Leishmania major cytochrome p450-like protein 0.0019 0.0005 0.0014
Schistosoma mansoni diacylglycerol O-acyltransferase 1 0.0021 0.0022 0.0022
Schistosoma mansoni neuroligin 3 (S09 family) 0.0058 0.0457 0.0457
Schistosoma mansoni microtubule-associated protein tau 0.0804 0.903 0.903
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0022 0.0022
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0149 0.1498 0.8345
Schistosoma mansoni axis inhibition protein axin 0.002 0.0017 0.0017
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0132 0.13 0.1575
Brugia malayi laminin-like protein K08C7.3 precursor 0.005 0.0358 0.0434
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0149 0.1498 0.8345
Brugia malayi hypothetical protein 0.0019 0.0001 0.0001
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.0028 0.0227
Plasmodium falciparum diacylglycerol O-acyltransferase 0.0021 0.0022 0.0165
Brugia malayi hypothetical protein 0.0043 0.0278 0.0336
Brugia malayi diacylglycerol acyltransferase 0.0021 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Onchocerca volvulus 0.0058 0.0457 0.0741
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0584 0.1511
Toxoplasma gondii acyl-CoA:diacylglycerol acyltransferase 1-related enzyme 0.0021 0.0022 0.0165
Brugia malayi Hydroxymethylglutaryl-coenzyme A reductase family protein 0.0144 0.1441 0.1745
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.0375 0.097
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.1261 0.1527
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0238 0.252 0.252
Loa Loa (eye worm) hypothetical protein 0.019 0.1976 0.2393
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0238 0.252 0.252
Loa Loa (eye worm) carbonic anhydrase 3 0.0355 0.3866 0.4681
Echinococcus multilocularis carbonic anhydrase 0.0132 0.13 0.13
Schistosoma mansoni hypothetical protein 0.0054 0.0411 0.0411
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0149 0.1498 0.8345
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0123 0.0317
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0021 0.0031 0.0146
Schistosoma mansoni hypothetical protein 0.0043 0.0278 0.0278
Schistosoma mansoni cell polarity protein 0.005 0.0358 0.0358
Leishmania major lanosterol synthase, putative 0.0133 0.1315 0.3402
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.0375 0.0375
Onchocerca volvulus 0.0058 0.0457 0.0741
Echinococcus multilocularis lipoxygenase domain containing protein 0.0043 0.0278 0.0278
Echinococcus multilocularis lysophospholipid acyltransferase 7 0.0021 0.0022 0.0022
Brugia malayi conserved hypotetical protein 0.0108 0.1029 0.1247
Brugia malayi latrophilin 2 splice variant baaae 0.0107 0.102 0.1235
Toxoplasma gondii acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha 0.0021 0.0022 0.0165
Echinococcus multilocularis ubiquitin specific protease 41 0.0125 0.1223 0.1223
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0125 0.1223 0.3163
Trypanosoma cruzi geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0028 0.0072
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.0022 0.0183
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0282 0.1547
Echinococcus multilocularis ecdysone induced protein 78C 0.0238 0.252 0.252
Trypanosoma brucei protein kinase, putative 0.0051 0.0375 0.097
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0058 0.0458 0.1185
Schistosoma mansoni hypothetical protein 0.0147 0.1472 0.1472
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1261 0.1261
Schistosoma mansoni ap endonuclease 0.0022 0.0037 0.0037
Schistosoma mansoni regulator of G protein signaling 0.002 0.0017 0.0017
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0022 0.0037 0.0178
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0278 0.0278
Leishmania major geranylgeranyltransferase, putative 0.0021 0.0028 0.0072
Echinococcus granulosus FTZ F1 alpha 0.0238 0.252 0.252
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0022 0.0027
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0022 0.0058
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0022 0.0037 0.0045
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0022 0.0058
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0374 0.0966
Plasmodium vivax DNA topoisomerase II, putative 0.0065 0.0533 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0149 0.1498 0.8345
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0022 0.0022
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0022 0.0022
Echinococcus granulosus Protein patched homolog 1 0.0104 0.0978 0.0978
Schistosoma mansoni lamin 0.0087 0.0785 0.0785
Schistosoma mansoni nuclear receptor nhr-48 0.0108 0.1029 0.1029
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0021 0.0031 0.6116
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.014
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0149 0.1498 0.8345
Brugia malayi exodeoxyribonuclease III family protein 0.0022 0.0037 0.0045
Echinococcus granulosus dna polymerase kappa 0.0043 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0022 0.0037 0.0096
Loa Loa (eye worm) hypothetical protein 0.0087 0.0785 0.095
Loa Loa (eye worm) hypothetical protein 0.004 0.0249 0.0302
Loa Loa (eye worm) hypothetical protein 0.004 0.0249 0.0302
Echinococcus multilocularis thyroid hormone receptor alpha 0.0384 0.4206 0.4206
Chlamydia trachomatis DNA gyrase subunit B 0.0035 0.0191 1
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0149 0.1498 0.8345
Echinococcus granulosus ubiquitin specific protease 41 0.0125 0.1223 0.1223
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0022 0.0022
Echinococcus granulosus protein cysteine N palmitoyltransferase 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0027
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0021 0.0022 0.0027
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0029 0.0123 0.0656
Loa Loa (eye worm) hypothetical protein 0.0157 0.1592 0.1927
Schistosoma mansoni membrane-bound acyltransferase/hhat 0.0021 0.0022 0.0022
Trypanosoma brucei glycerol uptake protein, putative 0.0021 0.0022 0.0058
Echinococcus granulosus GPCR family 2 0.005 0.0357 0.0357
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0238 0.252 0.252
Brugia malayi Latrophilin receptor protein 2 0.005 0.0357 0.0432
Loa Loa (eye worm) DR-78 0.0108 0.1029 0.1247
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0719 0.8058 0.8058
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0021 0.0028 0.0028
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0355 0.3866 0.4681
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0457 0.2523
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0328 0.0532
Entamoeba histolytica hypothetical protein 0.0038 0.0221 0.1803
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0157 0.1592 0.1927
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0022 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.002 0.0017 0.014
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0028 0.0034
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0019 0.0001 0.0001
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0108 0.1029 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.004 0.0104
Onchocerca volvulus 0.0043 0.0278 0.045
Echinococcus granulosus lysophospholipid acyltransferase 7 0.0021 0.0022 0.0022
Brugia malayi nuclear receptor NHR-67 0.0108 0.1029 0.1247
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0017 0.0017
Echinococcus multilocularis membrane bound acyltransferase:hhat 0.0021 0.0022 0.0022
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0017 0.0017
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.002 0.0017 0.0017
Echinococcus multilocularis expressed conserved protein 0.0097 0.0904 0.0904
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0019 0.0001 0.0001
Echinococcus granulosus Membrane bound O acyl transferase MBOAT 0.0021 0.0022 0.0022
Brugia malayi cytoplasmic intermediate filament protein 0.0047 0.0321 0.0388
Onchocerca volvulus 0.0019 0.0001 0.0002
Brugia malayi Carboxylesterase family protein 0.0058 0.0457 0.0553
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0017 0.0017
Brugia malayi Pepsin A precursor 0.0019 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0108 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0042 0.0268 0.0268
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0017 0.0021
Brugia malayi MAP kinase sur-1 0.0051 0.0375 0.0454
Echinococcus multilocularis slit 2 protein 0.005 0.0358 0.0358
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0221 0.0221
Echinococcus granulosus expressed protein 0.0393 0.4302 0.4302
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0149 0.1498 0.8345
Brugia malayi hypothetical protein 0.002 0.0017 0.0021
Trypanosoma cruzi lanosterol synthase, putative 0.0154 0.1558 0.4029
Brugia malayi hypothetical protein 0.0108 0.1029 0.1247
Echinococcus multilocularis acetylcholinesterase 0.0345 0.376 0.376
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0238 0.252 0.252
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0357 0.0357
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0125 0.1223 0.1223
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0175 0.1795 0.4642
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.002 0.0017 0.0021
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0125 0.1223 1
Echinococcus granulosus RUN 0.0043 0.0278 0.0278
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0125 0.1223 0.3163
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0058 0.0457 0.0457
Giardia lamblia Prenyltransferase 0.0021 0.0028 0.0227
Brugia malayi follicle stimulating hormone receptor 0.0249 0.2649 0.3208
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0021 0.0028 0.0034
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0108 0.1029 0.1247
Loa Loa (eye worm) hypothetical protein 0.0042 0.0268 0.0324
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.051 0.5652 0.5652
Entamoeba histolytica hypothetical protein 0.002 0.0017 0.014
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0132 0.13 0.1575
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0068 0.0175
Leishmania major carbonic anhydrase-like protein 0.0355 0.3866 1
Schistosoma mansoni hypothetical protein 0.0107 0.102 0.102
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0022 0.0022
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0125 0.1223 0.3163
Loa Loa (eye worm) membrane bound O-acyltransferase domain containing 1 0.0021 0.0022 0.0027
Trypanosoma brucei DNA topoisomerase ii 0.0051 0.0374 0.0966
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0282 0.073
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0149 0.1498 0.8345
Trypanosoma brucei DNA polymerase IV, putative 0.0036 0.0202 0.0523
Brugia malayi photoreceptor-specific nuclear receptor 0.0238 0.252 0.3051
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0068 0.1251
Echinococcus multilocularis RUN 0.0043 0.0278 0.0278
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0034
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.002 0.0017 0.0017
Schistosoma mansoni regulator of G protein signaling 0.002 0.0017 0.0017
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0238 0.252 0.252
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0021 0.0022 0.0027
Schistosoma mansoni hypothetical protein 0.0038 0.0221 0.0221
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0021 0.0028 0.0227
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0022 0.0027
Loa Loa (eye worm) hypothetical protein 0.0125 0.1223 0.1481
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0068 0.0513
Brugia malayi Eukaryotic aspartyl protease family protein 0.0019 0.0001 0.0001
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0125 0.1223 0.1223
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0065 0.0533 0.0646
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0022 0.0058
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0238 0.252 0.3051
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.002 0.0017 0.0017
Echinococcus granulosus diacylglycerol O acyltransferase 1 0.0021 0.0022 0.0022
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Echinococcus multilocularis neurogenic locus notch protein 0.005 0.0358 0.0358
Echinococcus multilocularis para nitrobenzyl esterase 0.0058 0.0457 0.0457
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0125 0.1223 0.1223
Echinococcus granulosus acetylcholinesterase 0.0345 0.376 0.376
Echinococcus multilocularis sterol O acyltransferase 1 0.0211 0.2214 0.2214
Loa Loa (eye worm) steroid hormone receptor 0.0238 0.252 0.3051
Loa Loa (eye worm) PXA domain-containing protein 0.002 0.0017 0.0021
Echinococcus multilocularis axis inhibition protein axin 0.002 0.0017 0.0017
Brugia malayi Carboxylesterase family protein 0.0058 0.0457 0.0553
Brugia malayi nuclear receptor NHR-88 0.0108 0.1029 0.1247
Onchocerca volvulus 0.0108 0.1029 0.1671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0238 0.252 0.3051
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0149 0.1498 0.8345
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0584 0.0707
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Leishmania major DNA topoisomerase ii 0.0058 0.0458 0.1185
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0357 0.0357
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.0028 0.0206
Schistosoma mansoni carbonic anhydrase-related 0.0132 0.13 0.13
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0355 0.3866 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0108 0.1029 0.1029
Loa Loa (eye worm) TOPoisomerase family member 0.0065 0.0533 0.0646
Giardia lamblia DNA topoisomerase II 0.0062 0.05 0.4093
Brugia malayi nuclear hormone receptor 0.0108 0.1029 0.1247
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0019 0.0001 0.0001
Echinococcus granulosus carbonic anhydrase II 0.0355 0.3866 0.3866
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Echinococcus multilocularis FTZ F1 alpha 0.0238 0.252 0.252
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.004 0.0104
Mycobacterium tuberculosis Carboxylesterase LipT 0.0058 0.0457 0.2523
Schistosoma mansoni cpg binding protein 0.0066 0.0543 0.0543
Loa Loa (eye worm) carboxylesterase 0.0058 0.0457 0.0553
Trypanosoma brucei unspecified product 0.0036 0.0202 0.0523
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0175 0.1795 0.4642
Onchocerca volvulus 0.0043 0.0278 0.045
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0175 0.1795 1
Schistosoma mansoni hypothetical protein 0.0043 0.0278 0.0278
Onchocerca volvulus 0.0019 0.0001 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0238 0.252 0.3051
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0183
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0345 0.376 0.376
Mycobacterium leprae putative cytochrome p450 0.0149 0.1498 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.002 0.0017 0.014
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.014
Schistosoma mansoni laminin gamma-3 chain 0.005 0.0358 0.0358
Loa Loa (eye worm) hypothetical protein 0.0107 0.102 0.1235
Schistosoma mansoni regulator of G protein signaling 0.002 0.0017 0.0017
Brugia malayi hypothetical protein 0.002 0.0017 0.0021
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0019 0.0001 0.0001
Brugia malayi CXXC zinc finger family protein 0.0062 0.0502 0.0608
Brugia malayi small heat shock protein 0.0608 0.6774 0.8203
Echinococcus granulosus o acyltransferase membrane bound domain 0.0021 0.0022 0.0022
Echinococcus multilocularis Polycystic kidney disease protein 0.0043 0.0278 0.0278
Schistosoma mansoni retinoid-x-receptor (RXR) 0.013 0.1276 0.1276
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Toxoplasma gondii hypothetical protein 0.0132 0.13 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0068 0.0513
Schistosoma mansoni rab6-interacting 0.0043 0.0278 0.0278
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.0375 0.0454
Brugia malayi MBOAT family protein 0.0021 0.0022 0.0027
Schistosoma mansoni lipoxygenase 0.012 0.1164 0.1164
Echinococcus granulosus BC026374 protein S09 family 0.0058 0.0457 0.0457
Echinococcus multilocularis protein cysteine N palmitoyltransferase 0.0021 0.0022 0.0022
Mycobacterium ulcerans DNA polymerase IV 0.0043 0.0282 0.1547
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0183
Trypanosoma brucei lanosterol synthase 0.0154 0.1558 0.4029
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0123 0.0149
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0.0037 1
Schistosoma mansoni geranylgeranyl transferase type I beta subunit 0.0021 0.0028 0.0028
Echinococcus multilocularis dnaJ subfamily B 0.0888 1 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0132 0.1306 0.1306
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0238 0.252 0.252
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0238 0.252 0.252
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0022 0.0037 0.0037
Brugia malayi nuclear hormone receptor family member nhr-6 0.0108 0.1029 0.1247
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1261 0.1261
Schistosoma mansoni RAR-like nuclear receptor 0.0238 0.252 0.252
Schistosoma mansoni ap endonuclease 0.0022 0.0037 0.0037
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0125 0.1223 0.1223
Loa Loa (eye worm) hypothetical protein 0.0054 0.0411 0.0498
Loa Loa (eye worm) hypothetical protein 0.005 0.0358 0.0434
Echinococcus multilocularis lamin 0.0087 0.0785 0.0785
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0093 0.0851 0.1031
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0125 0.1223 0.1481
Echinococcus multilocularis Rab geranylgeranyltransferase, beta subunit 0.0021 0.0028 0.0028
Brugia malayi hypothetical protein 0.013 0.1276 0.1545
Trypanosoma cruzi protein farnesyltransferase, putative 0.0021 0.0028 0.0072
Echinococcus multilocularis regulator of G protein signaling 0.002 0.0017 0.0017
Onchocerca volvulus Bile acid receptor homolog 0.0554 0.6162 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0238 0.252 0.252
Onchocerca volvulus 0.0238 0.252 0.4089
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0458 0.1185
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0851 0.0851
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0022 0.0037 0.0679
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0149 0.1498 0.8345
Echinococcus multilocularis geminin 0.0719 0.8058 0.8058
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0125 0.1223 0.1223
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0238 0.252 0.252
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0282 0.073
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.0562 0.4596
Loa Loa (eye worm) hypothetical protein 0.0104 0.0978 0.1184
Loa Loa (eye worm) hypothetical protein 0.013 0.1276 0.1545
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0348
Brugia malayi Nuclear hormone receptor E75 0.0108 0.1029 0.1247
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0104 0.0978 0.1184
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0355 0.3866 1
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0737 0.8259 1
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0004 0.0005
Loa Loa (eye worm) cytochrome P450 family protein 0.0029 0.0123 0.0149
Echinococcus granulosus cpg binding protein 0.0066 0.0543 0.0543
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0021 0.0028 0.0227
Giardia lamblia 3-hydroxy-3-methylglutaryl-coenzyme A reductase 0.0068 0.0562 0.4596
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.0022 0.0183
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0355 0.3866 0.4681
Trypanosoma cruzi GUP1, putative 0.0021 0.0022 0.0058
Brugia malayi hypothetical protein 0.0058 0.0457 0.0553
Leishmania major DNA polymerase kappa, putative 0.0022 0.004 0.0104
Brugia malayi Carboxylesterase family protein 0.0058 0.0457 0.0553
Trypanosoma brucei cytochrome P450, putative 0.0029 0.0123 0.0317
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0047 0.0321 0.0388
Entamoeba histolytica vacuolar protein sorting 26 0.0021 0.0022 0.0183
Brugia malayi orphan nuclear receptor NR2E1 0.0108 0.1029 0.1247
Loa Loa (eye worm) hypothetical protein 0.005 0.0358 0.0434
Echinococcus multilocularis lamin dm0 0.0087 0.0785 0.0785
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0027
Brugia malayi Probable protein farnesyltransferase beta subunit, putative 0.0021 0.0028 0.0034
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Mycobacterium tuberculosis Halimadienyl diphosphate synthase 0.0085 0.0766 0.4253
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Plasmodium falciparum geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.0028 0.0206
Toxoplasma gondii exonuclease III APE 0.0022 0.0037 0.0278
Echinococcus multilocularis diacylglycerol O acyltransferase 1 0.0021 0.0022 0.0022
Plasmodium vivax DNA gyrase subunit B, putative 0.0021 0.0031 0.0572
Brugia malayi aspartic protease BmAsp-2, identical 0.0019 0.0001 0.0001
Echinococcus granulosus expressed conserved protein 0.0097 0.0904 0.0904
Schistosoma mansoni gliotactin 0.0058 0.0457 0.0457
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0851 0.0851
Echinococcus granulosus regulator of G protein signaling 3 0.002 0.0017 0.0017
Schistosoma mansoni slit 0.005 0.0358 0.0358
Schistosoma mansoni zinc finger protein 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0132 0.13 0.13
Onchocerca volvulus 0.0058 0.0457 0.0741
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Schistosoma mansoni acetylcholinesterase 0.0058 0.0457 0.0457
Mycobacterium ulcerans DNA gyrase subunit B 0.0021 0.0031 0.0146
Brugia malayi Carboxylesterase family protein 0.0345 0.376 0.4552
Schistosoma mansoni patched 1 0.0104 0.0978 0.0978
Echinococcus multilocularis microtubule associated protein 2 0.0804 0.903 0.903
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0017 0.0017
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0357 0.0432
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0093 0.0851 0.1031
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Trypanosoma brucei 3-hydroxy-3-methylglutaryl-CoA reductase, putative 0.0144 0.1441 0.3727
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.014
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0238 0.252 0.3051
Trypanosoma cruzi DNA topoisomerase II, putative 0.0058 0.0458 0.1185
Schistosoma mansoni hydroxymethylglutaryl-CoA reductase (NADPH) 0.0144 0.1441 0.1441
Schistosoma mansoni hypothetical protein 0.0888 1 1
Schistosoma mansoni cpg binding protein 0.0062 0.0502 0.0502
Schistosoma mansoni geranylgeranyl transferase type II beta subunit 0.0021 0.0028 0.0028
Loa Loa (eye worm) hhat protein 0.0021 0.0022 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0149 0.1498 0.8345
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0238 0.252 0.252
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0019 0.0005 0.0014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0022 0.0027
Brugia malayi Carboxylesterase family protein 0.0058 0.0457 0.0553
Echinococcus multilocularis acetylcholinesterase 0.0345 0.376 0.376
Schistosoma mansoni nuclear hormone receptor 0.0238 0.252 0.252
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0108 0.1029 0.1671
Trypanosoma cruzi GUP1, putative 0.0021 0.0022 0.0058
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0058 0.0457 0.2523
Onchocerca volvulus 0.0087 0.0785 0.1274
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0149 0.1498 0.8345
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0737 0.8259 1
Brugia malayi laminin alpha chain 0.005 0.0358 0.0434
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0238 0.252 0.252
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0022 0.0183
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0737 0.8259 0.8259
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0068 0.0175
Brugia malayi Doublecortin family protein 0.0043 0.0278 0.0336
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0022 0.0022
Brugia malayi cytochrome P450 0.0019 0.0005 0.0006
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.013 0.1276 0.1276
Onchocerca volvulus 0.0058 0.0457 0.0741
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0058 0.0458 0.1185
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0149 0.1498 0.8345
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0021 0.0028 0.0227
Loa Loa (eye worm) intermediate filament protein 0.0087 0.0785 0.095
Trypanosoma cruzi 3-hydroxy-3-methylglutaryl-CoA reductase 0.0144 0.1441 0.3727
Trichomonas vaginalis spcc417.12 protein, putative 0.0058 0.0457 0.3735
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.014
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0021 0.0028 0.0206
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0007 0.0009
Brugia malayi EGF-like domain containing protein 0.005 0.0358 0.0434
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0047 0.0328 0.0532
Loa Loa (eye worm) hypothetical protein 0.0043 0.0278 0.0336
Leishmania major mitochondrial DNA topoisomerase II 0.0051 0.0374 0.0966
Echinococcus granulosus thyroid hormone receptor alpha 0.0108 0.1029 0.1029
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0457 0.0457
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0282 0.073
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0125 0.1223 0.1223
Entamoeba histolytica hypothetical protein 0.0038 0.0221 0.1803
Onchocerca volvulus 0.0108 0.1029 0.1671
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0238 0.252 0.3051
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0022 0.0022
Loa Loa (eye worm) carboxylesterase 0.0058 0.0457 0.0553
Leishmania major hypothetical protein, conserved 0.0021 0.0022 0.0058
Schistosoma mansoni DNA topoisomerase II 0.0065 0.0533 0.0533
Schistosoma mansoni o-acyltransferase (membrane bound) domain containing protein 0.0021 0.0022 0.0022
Echinococcus multilocularis GPCR, family 2 0.005 0.0357 0.0357
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0021 0.0031 0.0234
Loa Loa (eye worm) hypothetical protein 0.013 0.1276 0.1545
Brugia malayi Carboxylesterase family protein 0.0345 0.376 0.4552
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0108 0.1029 0.1671
Schistosoma mansoni hypothetical protein 0.0019 0.0005 0.0005
Brugia malayi hypothetical protein 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.005 0.0357 0.0432
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0021 0.0028 0.0028
Echinococcus granulosus Nuclear hormone receptor HR96 0.0108 0.1029 0.1029
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0584 0.0584
Brugia malayi Cytochrome P450 family protein 0.0029 0.0123 0.0149
Loa Loa (eye worm) hypothetical protein 0.0345 0.376 0.4552
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Brugia malayi PXA domain containing protein 0.002 0.0017 0.0021
Brugia malayi RNA binding protein 0.0128 0.1261 0.1527
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0132 0.13 0.1575
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0058 0.0457 0.3735
Trypanosoma brucei DNA polymerase kappa, putative 0.0033 0.0161 0.0417
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0375 0.3068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.012 0.1164 0.1164
Brugia malayi PXA domain containing protein 0.002 0.0017 0.0021
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0238 0.252 0.252
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0144 0.1441 0.1745
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0065 0.0533 0.0533
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0584 0.0707
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0058 0.0457 0.0457
Brugia malayi Steroid receptor seven-up type 2 0.0238 0.252 0.3051
Entamoeba histolytica hypothetical protein 0.002 0.0017 0.014
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.0375 0.3068
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0125 0.1223 1
Echinococcus multilocularis beta adrenergic receptor kinase 0.0021 0.0022 0.0022
Echinococcus granulosus cytochrome P450 2K1 0.0019 0.0005 0.0005
Leishmania major cytochrome p450-like protein 0.0019 0.0005 0.0014
Echinococcus multilocularis Regulator of G protein signaling 20 0.002 0.0017 0.0017
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0022 0.0037 0.0304
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.1223 0.148
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Echinococcus granulosus transcription factor Dp 1 0.004 0.0248 0.0248
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.0375 0.0375
Schistosoma mansoni loxhd1 0.0043 0.0278 0.0278
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.014
Schistosoma mansoni hypothetical protein 0.005 0.0357 0.0357
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0238 0.252 0.3051
Echinococcus multilocularis regulator of G protein signaling 7 0.002 0.0017 0.0017
Loa Loa (eye worm) MBOAT family protein 0.0021 0.0022 0.0027
Echinococcus granulosus para nitrobenzyl esterase 0.0058 0.0457 0.0457
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0175 0.1795 1
Echinococcus granulosus Regulator of G protein signaling 20 0.002 0.0017 0.0017
Echinococcus multilocularis carbonic anhydrase 0.0132 0.13 0.13
Trypanosoma cruzi glycerol uptake protein, putative 0.0021 0.0022 0.0058
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0851 0.0851
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Toxoplasma gondii cytochrome p450 superfamily protein 0.0019 0.0005 0.0033
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0108 0.1029 0.1029
Toxoplasma gondii Rab geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0028 0.0206
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0238 0.252 0.3051
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0028 0.0227
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1261 0.1261
Brugia malayi ecdysone receptor 0.0108 0.1029 0.1247
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0021 0.0028 0.0206
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0238 0.252 0.3051
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0149 0.1498 0.8345
Loa Loa (eye worm) hypothetical protein 0.0029 0.0116 0.014
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Schistosoma mansoni hypothetical protein 0.0719 0.8058 0.8058
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Brugia malayi hypothetical protein 0.0043 0.0278 0.0336
Loa Loa (eye worm) hypothetical protein 0.0211 0.2214 0.268
Loa Loa (eye worm) cytochrome P450 family protein 0.0019 0.0005 0.0006
Entamoeba histolytica hypothetical protein 0.0038 0.0221 0.1803
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0147 0.1472 0.1472
Echinococcus granulosus sterol O acyltransferase 1 0.0211 0.2214 0.2214
Echinococcus granulosus Polycystic kidney disease protein 0.0043 0.0278 0.0278
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0375 0.3068
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0021 0.0028 0.0072
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0584 0.1511
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0238 0.252 0.3051
Trypanosoma brucei DNA polymerase IV, putative 0.0043 0.0282 0.073
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0149 0.1498 0.8345
Loa Loa (eye worm) hypothetical protein 0.005 0.0358 0.0434
Schistosoma mansoni z-protein (S1r protein) 0.002 0.0017 0.0017
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0355 0.3866 0.3866
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0584 0.1511
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.005 0.0358 0.0434
Brugia malayi Niemann-Pick C1 protein precursor 0.0104 0.0976 0.1182
Schistosoma mansoni thyroid hormone receptor 0.0384 0.4206 0.4206
Echinococcus multilocularis hydroxymethylglutaryl coenzyme A reductase 0.0144 0.1441 0.1441
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.013 0.1276 0.1276
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0125 0.1223 1
Onchocerca volvulus 0.0062 0.0502 0.0815
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.002 0.0017 0.0017
Schistosoma mansoni nuclear receptor 0.0108 0.1029 0.1029
Brugia malayi aspartic protease BmAsp-1, identical 0.0019 0.0001 0.0001
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.013 0.1276 0.1545
Toxoplasma gondii histone lysine methyltransferase SET1 0.0118 0.1144 0.8797
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0221 0.0221
Loa Loa (eye worm) hypothetical protein 0.0132 0.13 0.1575
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0149 0.1498 0.8345
Schistosoma mansoni axis inhibition protein axin 0.002 0.0017 0.0017
Brugia malayi MBOAT family protein 0.0021 0.0022 0.0027
Echinococcus granulosus sterol regulatory element binding protein 0.0104 0.0978 0.0978
Entamoeba histolytica membrane-bound O-acyltransferase (MBOAT ) family protein 0.0021 0.0022 0.0183
Schistosoma mansoni rab6-interacting 0.0043 0.0278 0.0278
Loa Loa (eye worm) aspartyl protease 6 0.0019 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.0238 0.252 0.3051
Leishmania major glycerol uptake protein, putative 0.0021 0.0022 0.0058
Mycobacterium ulcerans carboxylesterase, LipT 0.0058 0.0457 0.2523
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0238 0.252 0.3051
Brugia malayi steroid hormone receptor 0.0238 0.252 0.3051
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Loa Loa (eye worm) hypothetical protein 0.0608 0.6774 0.8203
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0028 0.0227
Plasmodium falciparum DNA topoisomerase 2 0.0065 0.0533 0.4098
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0051 0.0374 0.0966
Leishmania major farnesyltransferase beta subunit 0.0021 0.0028 0.0072
Entamoeba histolytica geranylgeranyl transferase beta subunit 0.0021 0.0028 0.0227
Toxoplasma gondii hypothetical protein 0.0021 0.0022 0.0165
Schistosoma mansoni regulator of G protein signaling 0.002 0.0017 0.0017
Trichomonas vaginalis transmembrane protein nessy, putative 0.0021 0.0022 0.0183
Loa Loa (eye worm) hypothetical protein 0.0044 0.0287 0.0348
Echinococcus granulosus hydroxymethylglutaryl coenzyme A reductase 0.0144 0.1441 0.1441
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0022 0.0037 0.0096
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0238 0.252 0.252
Echinococcus granulosus acetylcholinesterase 0.0345 0.376 0.376
Echinococcus granulosus intermediate filament protein 0.0087 0.0785 0.0785
Loa Loa (eye worm) CXXC zinc finger family protein 0.0062 0.0502 0.0608
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0065 0.0533 0.0646
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0238 0.252 0.3051
Trichomonas vaginalis DNA topoisomerase II, putative 0.0065 0.0533 0.4363
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0457 0.0457
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.1261 0.1527
Schistosoma mansoni leukocyte receptor cluster (lrc) member 4 protein 0.0021 0.0022 0.0022
Leishmania major 3-hydroxy-3-methylglutaryl-CoA reductase 0.0144 0.1441 0.3727
Schistosoma mansoni steroid hormone receptor ad4bp 0.0238 0.252 0.252
Brugia malayi Intermediate filament tail domain containing protein 0.0087 0.0785 0.095
Echinococcus multilocularis nuclear receptor nhr 48 0.0108 0.1029 0.1029
Brugia malayi hypothetical protein 0.0108 0.1029 0.1247
Schistosoma mansoni BC026374 protein (S09 family) 0.0058 0.0457 0.0457
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0238 0.252 0.3051
Plasmodium vivax multidomain scavenger receptor, putative 0.0043 0.0278 0.5194
Giardia lamblia Rab geranylgeranyltransferase 0.0021 0.0028 0.0227
Brugia malayi MH2 domain containing protein 0.0125 0.1223 0.148
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.0375 0.097
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0149 0.1498 0.8345
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0157 0.1592 0.1927
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0238 0.252 0.3051
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0238 0.252 0.3051
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0001 0.0001
Echinococcus granulosus membrane bound acyltransferase:hhat 0.0021 0.0022 0.0022
Schistosoma mansoni hypothetical protein 0.0043 0.0278 0.0278
Echinococcus multilocularis Niemann Pick C1 protein 0.0104 0.0976 0.0976
Loa Loa (eye worm) doublecortin family protein 0.0043 0.0278 0.0336
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0282 0.073
Onchocerca volvulus 0.0087 0.0785 0.1274
Loa Loa (eye worm) hypothetical protein 0.0033 0.0161 0.0195
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Loa Loa (eye worm) hypothetical protein 0.0238 0.252 0.3051
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0058 0.0457 0.0457
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0149 0.1498 0.8345
Trypanosoma brucei geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0028 0.0072
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0087 0.0785 0.095
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0149 0.1498 0.8345
Brugia malayi polk-prov protein 0.0033 0.0161 0.0195
Brugia malayi hypothetical protein 0.0025 0.0068 0.0082
Leishmania major glycerol uptake protein, putative 0.0021 0.0022 0.0058
Brugia malayi Probable DNA topoisomerase II 0.0065 0.0533 0.0646
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0357 0.0357
Schistosoma mansoni hypothetical protein 0.0043 0.0278 0.0278
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.0375 0.097
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Trypanosoma cruzi lanosterol synthase, putative 0.0154 0.1558 0.4029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0238 0.252 0.3051
Loa Loa (eye worm) hypothetical protein 0.0043 0.0278 0.0336
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0584 0.0584
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0132 0.13 0.1575
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0093 0.0851 0.0851
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.0562 0.4596
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0.0037 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0068 0.0175
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0021 0.0028 0.0028
Trichomonas vaginalis DNA polymerase eta, putative 0.0043 0.0282 0.2307
Echinococcus granulosus regulator of G protein signaling 7 0.002 0.0017 0.0017
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0355 0.3866 0.4681
Brugia malayi Hhat protein 0.0021 0.0022 0.0027
Echinococcus multilocularis carbonic anhydrase II 0.0355 0.3866 0.3866
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0238 0.252 0.3051
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0238 0.252 0.252
Echinococcus granulosus lamin dm0 0.0087 0.0785 0.0785
Schistosoma mansoni hypothetical protein 0.005 0.0357 0.0357
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0149 0.1498 0.8345
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0375 0.3068
Trichomonas vaginalis 3-hydroxy-3-methylglutaryl-coenzyme A reductase, putative 0.0068 0.0562 0.4596
Loa Loa (eye worm) diacylglycerol acyltransferase 0.0021 0.0022 0.0027
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0737 0.8259 0.8259
Echinococcus multilocularis carbonic anhydrase 0.0132 0.13 0.13
Entamoeba histolytica Rab geranylgeranyltransferase beta subunit, putative 0.0021 0.0028 0.0227
Loa Loa (eye worm) hypothetical protein 0.0085 0.0767 0.0928
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0093 0.0851 0.0851
Trypanosoma cruzi hypothetical protein, conserved 0.0021 0.0028 0.0072
Schistosoma mansoni regulator of G protein signaling 0.002 0.0017 0.0017
Brugia malayi Cytochrome P450 family protein 0.0019 0.0005 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0238 0.252 0.3051
Echinococcus multilocularis Niemann Pick C1 protein 0.0207 0.2169 0.2169
Echinococcus multilocularis o acyltransferase (membrane bound) domain 0.0021 0.0022 0.0022
Leishmania major cytochrome p450-like protein 0.0029 0.0123 0.0317
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0104 0.0976 0.7986
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0021 0.0028 0.0227
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Echinococcus granulosus microtubule associated protein 2 0.0804 0.903 0.903
Mycobacterium ulcerans oxidoreductase 0.013 0.1278 0.7115
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.0375 0.097
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.0375 0.0375
Brugia malayi Cytochrome P450 family protein 0.0019 0.0005 0.0006
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0022 0.0037 0.0096
Schistosoma mansoni carbonic anhydrase 0.0132 0.13 0.13
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Giardia lamblia DINP protein human, muc B family 0.0022 0.004 0.0328
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.0978 0.7999
Brugia malayi MBOAT family protein 0.0021 0.0022 0.0027
Echinococcus multilocularis carboxylesterase 5A 0.0345 0.376 0.376
Entamoeba histolytica hypothetical protein 0.0021 0.0022 0.0183
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0249 0.2649 0.3208
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.1223 0.148
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.0028 0.0227
Schistosoma mansoni hypothetical protein 0.0043 0.0278 0.0278
Brugia malayi TAR-binding protein 0.0128 0.1261 0.1527
Echinococcus multilocularis regulator of G protein signaling 3 0.002 0.0017 0.0017
Brugia malayi Regulator of G protein signaling domain containing protein 0.002 0.0017 0.0021
Echinococcus granulosus slit 2 protein 0.005 0.0358 0.0358
Loa Loa (eye worm) acetylcholinesterase 1 0.0345 0.376 0.4552
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Loa Loa (eye worm) RNA binding protein 0.0128 0.1261 0.1527
Plasmodium falciparum LCCL domain-containing protein 0.0043 0.0278 0.2129
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0149 0.1498 0.8345
Echinococcus multilocularis geranylgeranyl transferase type I beta subunit 0.0021 0.0028 0.0028
Entamoeba histolytica hypothetical protein, conserved 0.0021 0.0022 0.0183
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0068 0.0513
Leishmania major glycerol uptake protein, putative 0.0021 0.0022 0.0058
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0175 0.1795 0.4642
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0022 0.0037 0.0304
Echinococcus granulosus beta-adrenergic receptor kinase 0.0021 0.0022 0.0022
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0021 0.0028 0.0227
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0149 0.1498 0.8345
Plasmodium falciparum carbonic anhydrase 0.0132 0.13 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0238 0.252 0.3051
Echinococcus granulosus Niemann Pick C1 protein 0.0104 0.0976 0.0976
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.0375 0.3068
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0021 0.0022 0.0027
Echinococcus granulosus tar DNA binding protein 0.0128 0.1261 0.1261
Schistosoma mansoni tar DNA-binding protein 0.0128 0.1261 0.1261
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0238 0.252 0.252
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Trichomonas vaginalis ap endonuclease, putative 0.0022 0.0037 0.0304
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0238 0.252 0.252
Echinococcus granulosus nuclear receptor nhr 48 0.0108 0.1029 0.1029
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0238 0.252 0.252
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Echinococcus granulosus Nuclear hormone receptor HR96 0.0108 0.1029 0.1029
Echinococcus granulosus neuroligin 0.0058 0.0457 0.0457
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0584 0.4776
Echinococcus granulosus Niemann Pick C1 protein 0.0207 0.2169 0.2169
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0238 0.252 0.252
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0043 0.0282 0.2307
Loa Loa (eye worm) CYP4Cod1 0.0029 0.0123 0.0149
Brugia malayi Cytochrome P450 family protein 0.0029 0.0123 0.0149
Brugia malayi A-kinase anchor protein 10, precursor 0.002 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0104 0.0976 0.1182
Echinococcus multilocularis pikachurin 0.005 0.0358 0.0358
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0022 0.0022
Trichomonas vaginalis conserved hypothetical protein 0.002 0.0017 0.014
Brugia malayi hypothetical protein 0.013 0.1276 0.1545
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0108 0.1029 0.1029
Trypanosoma cruzi cytochrome P450, putative 0.0029 0.0123 0.0317
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.005 0.0358 0.0358
Echinococcus multilocularis cpg binding protein 0.0066 0.0543 0.0543
Loa Loa (eye worm) RGS-3 protein 0.002 0.0017 0.0021
Entamoeba histolytica hypothetical protein 0.0038 0.0221 0.1803
Loa Loa (eye worm) hypothetical protein 0.0108 0.1029 0.1247
Echinococcus multilocularis tar DNA binding protein 0.0128 0.1261 0.1261
Loa Loa (eye worm) hypothetical protein 0.0132 0.13 0.1575
Loa Loa (eye worm) hypothetical protein 0.0132 0.13 0.1575
Echinococcus granulosus lipoxygenase domain containing protein 0.0043 0.0278 0.0278
Trichomonas vaginalis protein farnesyltransferase beta subunit, putative 0.0021 0.0028 0.0227
Schistosoma mansoni hypothetical protein 0.0021 0.0022 0.0022
Loa Loa (eye worm) TAR-binding protein 0.0128 0.1261 0.1527
Echinococcus granulosus carboxylesterase 5A 0.0345 0.376 0.376
Schistosoma mansoni polycystin 1-related 0.0043 0.0278 0.0278
Brugia malayi ecdysteroid receptor 0.0554 0.6162 0.7462
Trypanosoma cruzi DNA polymerase kappa, putative 0.0043 0.0282 0.073
Plasmodium falciparum DNA gyrase subunit B 0.0021 0.0031 0.0234
Loa Loa (eye worm) hypothetical protein 0.0058 0.0457 0.0553
Leishmania major hypothetical protein, conserved 0.0025 0.0068 0.0175
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0093 0.0851 0.0851
Schistosoma mansoni cathepsin D (A01 family) 0.0019 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.013 0.1276 0.1545
Loa Loa (eye worm) hypothetical protein 0.0019 0.0001 0.0001
Onchocerca volvulus 0.0021 0.0022 0.0036
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0019 0.0001 0.0001
Brugia malayi Nuclear hormone receptor-like 1 0.013 0.1276 0.1545
Brugia malayi Nuclear hormone receptor E75 0.0108 0.1029 0.1247
Echinococcus multilocularis neuroligin 0.0058 0.0457 0.0457
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0034
Plasmodium vivax geranylgeranyl transferase type2 beta subunit, putative 0.0021 0.0028 0.0503

Activities

Activity type Activity value Assay description Source Reference
MISS T/C (functional) = 0.88 In vivo blood glucose was determined in obese, hyperglycemic, hyperinsulinemic, insulin-resistant KKAy mice after a dose of 500 mg/kg for 4 days ChEMBL. 11312922

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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