Detailed information for compound 254887

Basic information

Technical information
  • TDR Targets ID: 254887
  • Name: 3-[[(2S)-2-[bis(4-methoxyphenoxy)phosphorylme thylamino]-3-(4-phenylphenyl)propanoyl]amino] propanoic acid
  • MW: 618.613 | Formula: C33H35N2O8P
  • H donors: 3 H acceptors: 4 LogP: 2.89 Rotable bonds: 17
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1ccc(cc1)OP(=O)(Oc1ccc(cc1)OC)CN[C@H](C(=O)NCCC(=O)O)Cc1ccc(cc1)c1ccccc1
  • InChi: 1S/C33H35N2O8P/c1-40-27-12-16-29(17-13-27)42-44(39,43-30-18-14-28(41-2)15-19-30)23-35-31(33(38)34-21-20-32(36)37)22-24-8-10-26(11-9-24)25-6-4-3-5-7-25/h3-19,31,35H,20-23H2,1-2H3,(H,34,38)(H,36,37)/t31-/m0/s1
  • InChiKey: CZSSGPCJACDKIX-HKBQPEDESA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-[[(2S)-2-[bis(4-methoxyphenoxy)phosphorylmethylamino]-1-oxo-3-(4-phenylphenyl)propyl]amino]propanoic acid
  • 3-[[(2S)-2-[bis(4-methoxyphenoxy)phosphorylmethylamino]-3-(4-phenylphenyl)propanoyl]amino]propionic acid

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii LsmAD domain-containing protein 0.0048 0.0147 0.0819
Schistosoma mansoni P2X receptor subunit 0.0512 0.2045 0.4346
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0281 0.1102 0.5318
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Onchocerca volvulus 0.0028 0.0066 0.0389
Echinococcus granulosus slit 2 protein 0.0039 0.0113 0.024
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Onchocerca volvulus 0.0281 0.1102 0.653
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Plasmodium falciparum histone acetyltransferase GCN5 0.004 0.0117 0.7941
Brugia malayi PAS domain containing protein 0.005 0.0157 0.0758
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.0222 0.0471
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0015 0.0215
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0078 0.0378
Brugia malayi G protein-coupled receptor F59B2.13 0.0281 0.1102 0.5318
Mycobacterium tuberculosis Conserved protein 0.0037 0.0104 0.0071
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.002 0.0033 0.0011
Echinococcus granulosus geminin 0.0175 0.0667 0.1417
Onchocerca volvulus 0.0037 0.0104 0.0615
Plasmodium vivax importin-beta 2, putative 0.0021 0.0037 0.2142
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0132 0.078
Mycobacterium tuberculosis Conserved protein 0.0037 0.0104 0.0071
Schistosoma mansoni sodium-dependent amino acid transporter 0.0034 0.009 0.0191
Onchocerca volvulus 0.0281 0.1102 0.653
Mycobacterium ulcerans putative regulatory protein 0.0037 0.0104 0.0082
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi beta-lactamase 0.0037 0.0104 0.0501
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.002 0.0033 0.0011
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0065 0.0217 0.0461
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0063 0.0211 0.0449
Brugia malayi Animal haem peroxidase family protein 0.0281 0.1102 0.5316
Echinococcus multilocularis protein jagged 2 0.0039 0.0113 0.024
Brugia malayi acetyltransferase, GNAT family protein 0.0149 0.0563 0.2718
Echinococcus multilocularis neurogenic locus protein delta 0.0039 0.0113 0.024
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0108 0.0392 0.1891
Echinococcus multilocularis neurogenic locus notch protein 0.0039 0.0113 0.024
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0031
Brugia malayi Dopamine receptor protein 2 0.0281 0.1102 0.5318
Loa Loa (eye worm) notch protein 0.0039 0.0113 0.0546
Echinococcus multilocularis geminin 0.0175 0.0667 0.1417
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0281 0.1102 0.5318
Echinococcus multilocularis neurogenic locus notch protein 0.0039 0.0113 0.024
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0078 0.1686
Brugia malayi Animal haem peroxidase family protein 0.0281 0.1102 0.5316
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0149 0.0563 0.1197
Echinococcus granulosus serotonin receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Echinococcus multilocularis dna polymerase eta 0.0075 0.0257 0.0547
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0034 0.009 1
Echinococcus granulosus protein jagged 1 0.0039 0.0113 0.024
Echinococcus multilocularis snurportin 1 0.0222 0.0861 0.183
Brugia malayi putative neuropeptide receptor 0.0281 0.1102 0.5318
Leishmania major DNA polymerase eta, putative 0.0075 0.0257 0.5808
Loa Loa (eye worm) hypothetical protein 0.0082 0.0287 0.1385
Schistosoma mansoni hypothetical protein 0.002 0.0033 0.007
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0066 0.0222 0.107
Brugia malayi Cytochrome P450 family protein 0.0031 0.0078 0.0378
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0063 0.0211 0.0449
Trypanosoma cruzi cytochrome P450, putative 0.0031 0.0078 0.1686
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0065 0.0218 0.1215
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis cpg binding protein 0.0031 0.008 0.017
Brugia malayi RNA, U transporter 1 0.0059 0.0194 0.0936
Schistosoma mansoni neuropeptide receptor 0.0281 0.1102 0.2342
Schistosoma mansoni survival motor neuron protein 0.005 0.0155 0.033
Schistosoma mansoni transcription factor LCR-F1 0.0063 0.021 0.0446
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Echinococcus granulosus tm gpcr rhodopsin 0.0281 0.1102 0.2342
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0106 0.2147
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0281 0.1102 0.2342
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0281 0.1102 0.2342
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0075 0.0261 0.1545
Schistosoma mansoni hypothetical protein 0.0063 0.021 0.0446
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0163
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0281 0.1102 0.2342
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0104 0.0501
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0281 0.1102 0.2342
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0104 0.0615
Brugia malayi hypothetical protein 0.0063 0.021 0.1012
Echinococcus granulosus g protein coupled receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0433
Loa Loa (eye worm) hypothetical protein 0.0168 0.064 0.309
Echinococcus multilocularis neural cadherin 0.0039 0.0113 0.024
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.0102 0.2235
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Trypanosoma brucei unspecified product 0.0038 0.0107 0.2175
Loa Loa (eye worm) CYP4Cod1 0.0031 0.0078 0.0378
Brugia malayi hypothetical protein 0.0168 0.064 0.309
Echinococcus granulosus notch 0.0039 0.0113 0.024
Trypanosoma cruzi DNA polymerase eta, putative 0.0075 0.0257 0.5808
Mycobacterium leprae Conserved hypothetical protein 0.002 0.0033 0.0028
Schistosoma mansoni hypothetical protein 0.0026 0.0058 0.0123
Brugia malayi Delta serrate ligand family protein 0.0039 0.0113 0.0546
Plasmodium vivax ataxin-2 like protein, putative 0.0048 0.0147 0.8498
Onchocerca volvulus 0.0281 0.1102 0.653
Brugia malayi Peroxidasin 0.0281 0.1102 0.5316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0113 0.0546
Echinococcus granulosus cpg binding protein 0.0031 0.008 0.017
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0026 0.0058 0.028
Loa Loa (eye worm) hypothetical protein 0.0022 0.004 0.0193
Brugia malayi Cytochrome P450 family protein 0.0083 0.0291 0.1403
Plasmodium falciparum amino acid transporter, putative 0.0034 0.009 0.6111
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.2457 1 1
Trichomonas vaginalis rotamase, putative 0.0025 0.0055 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0025 0.0055 0.0267
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0026 0.0058 0.0123
Brugia malayi notch-like transmembrane receptor 0.0039 0.0113 0.0546
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0026 0.0058 0.0123
Echinococcus granulosus tm gpcr rhodopsin 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0111 0.0407 0.1966
Echinococcus multilocularis slit 2 protein 0.0039 0.0113 0.024
Echinococcus granulosus g protein coupled receptor 0.0281 0.1102 0.2342
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0281 0.1102 0.2342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Trichomonas vaginalis set domain proteins, putative 0.0424 0.1687 1
Schistosoma mansoni opsin-like receptor 0.0281 0.1102 0.2342
Echinococcus granulosus importin subunit beta 1 0.0021 0.0037 0.0079
Giardia lamblia High cysteine protein 0.0039 0.0113 0.0842
Brugia malayi hypothetical protein 0.0034 0.009 0.0433
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0039 0.0113 0.067
Treponema pallidum fructose-bisphosphate aldolase 0.0301 0.1185 0.5605
Brugia malayi larval opioid receptor 0.0281 0.1102 0.5318
Schistosoma mansoni neuropeptide receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis p2X purinoceptor 4 0.1162 0.4705 1
Echinococcus granulosus neuropeptide Y receptor 0.0281 0.1102 0.2342
Brugia malayi ImpB/MucB/SamB family protein 0.0075 0.0257 0.1241
Leishmania major DNA damage repair protein, putative 0.0017 0.0022 0.0379
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0281 0.1102 0.5318
Mycobacterium tuberculosis Conserved hypothetical protein 0.045 0.1794 0.1767
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0066 0.0317
Echinococcus granulosus snurportin 1 0.0222 0.0861 0.183
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0031
Schistosoma mansoni rotamase 0.0025 0.0055 0.0118
Onchocerca volvulus 0.005 0.0155 0.0921
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0119 0.0439 0.3705
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0037 0.0104 0.0615
Loa Loa (eye worm) hypothetical protein 0.0111 0.0407 0.1966
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Onchocerca volvulus Slit protein homolog 0.0039 0.0113 0.067
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0025 0.0053 0.0904
Brugia malayi beta-lactamase family protein 0.0037 0.0104 0.0501
Leishmania major cytochrome p450-like protein 0.002 0.0033 0.0639
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0149 0.0563 0.1197
Echinococcus multilocularis sex peptide receptor 0.0281 0.1102 0.2342
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0132 0.028
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Echinococcus granulosus muscleblind protein 0.0154 0.0582 0.1237
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0015 0.0015 0.0842
Onchocerca volvulus 0.0104 0.0379 0.2247
Leishmania major hypothetical protein, conserved 0.0048 0.0147 0.3268
Loa Loa (eye worm) cytochrome P450 0.002 0.0033 0.0159
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0281 0.1102 0.2342
Echinococcus multilocularis neuropeptide Y receptor 0.0281 0.1102 0.2342
Echinococcus granulosus sex peptide receptor 0.0281 0.1102 0.2342
Schistosoma mansoni biogenic amine receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Onchocerca volvulus Chorion peroxidase homolog 0.0281 0.1102 0.6528
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0261 0.5889
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0005 0.0031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0281 0.1102 0.2342
Mycobacterium leprae putative cytochrome p450 0.002 0.0033 0.0028
Echinococcus granulosus histone lysine methyltransferase setb 0.0054 0.0173 0.0368
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0119 0.0439 0.2118
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0106 0.0384 0.0816
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0433
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0063 0.0211 0.0449
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0025 0.0053 0.11
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0222 0.0471
Brugia malayi Melibiase family protein 0.007 0.024 0.1158
Mycobacterium tuberculosis Conserved protein 0.0037 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.007 0.024 0.1158
Loa Loa (eye worm) G-protein coupled receptor 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0281 0.1102 0.653
Schistosoma mansoni neuropeptide receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0501
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0433
Echinococcus multilocularis lamin 0.0028 0.0066 0.014
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0104 0.0071
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0066 0.0317
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0005 0.0011
Echinococcus multilocularis transfer RNA-Lys 0.0037 0.0104 0.0221
Echinococcus multilocularis 0.002 0.0033 0.007
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.002 0.0033 0.0011
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.002 0.0033 0.0011
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0007 0.0014
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0222 0.0471
Echinococcus multilocularis neuropeptide s receptor 0.0281 0.1102 0.2342
Schistosoma mansoni sodium/chloride dependent transporter 0.0108 0.0392 0.0833
Schistosoma mansoni cpg binding protein 0.0031 0.008 0.017
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0281 0.1102 0.2342
Echinococcus granulosus neuropeptide Y receptor 0.0281 0.1102 0.2342
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Schistosoma mansoni ran 0.0015 0.0015 0.0031
Onchocerca volvulus 0.0281 0.1102 0.653
Brugia malayi neuropeptide F receptor 0.0281 0.1102 0.5318
Echinococcus granulosus hypothetical protein 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.009 0.0191
Brugia malayi bHLH-PAS transcription factor 0.0037 0.0104 0.0501
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0015
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0261 0.5889
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.0554 0.0549
Trichomonas vaginalis esterase, putative 0.0037 0.0104 0.0615
Leishmania major hypothetical protein, conserved 0.0037 0.0104 0.2272
Schistosoma mansoni lamin 0.0028 0.0066 0.014
Loa Loa (eye worm) blistered cuticle protein 3 0.0281 0.1102 0.5316
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0106 0.0384 0.0816
Schistosoma mansoni intermediate filament proteins 0.0028 0.0066 0.014
Mycobacterium ulcerans DNA polymerase IV 0.0075 0.0261 0.024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Brugia malayi GCC2 and GCC3 family protein 0.0039 0.0113 0.0546
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0056 0.018 0.0382
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.0177 0.1491
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0022 0.0167
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.009 0.0191
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0104 0.0615
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0222 0.0861 0.4154
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0331 0.0704
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0022 0.0379
Schistosoma mansoni aryl hydrocarbon receptor 0.005 0.0157 0.0334
Echinococcus multilocularis notch 0.0039 0.0113 0.024
Echinococcus granulosus cytochrome P450 2K1 0.002 0.0033 0.007
Echinococcus granulosus survival motor neuron protein 1 0.0244 0.0949 0.2018
Brugia malayi sulfakinin receptor protein 0.0281 0.1102 0.5318
Echinococcus granulosus protein jagged 2 0.0039 0.0113 0.024
Loa Loa (eye worm) TYRA-2 protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0027 0.0064 0.0307
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0082 0.0287 0.1385
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0163
Onchocerca volvulus 0.0039 0.0113 0.067
Brugia malayi neuropeptide F receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0038 0.0106 0.051
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0013 0.0005 0.0011
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0281 0.1102 0.2342
Schistosoma mansoni histamine h1 receptor 0.0281 0.1102 0.2342
Trypanosoma cruzi importin beta-1 subunit, putative 0.0017 0.0021 0.0362
Echinococcus multilocularis protein jagged 1 0.0039 0.0113 0.024
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0022 0.1252
Trichomonas vaginalis rotamase, putative 0.0025 0.0053 0.0314
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.0177 0.0375
Echinococcus multilocularis dna polymerase kappa 0.0075 0.0261 0.0554
Echinococcus multilocularis neuropeptides capa receptor 0.0281 0.1102 0.2342
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Echinococcus multilocularis microtubule associated protein 2 0.0712 0.2863 0.6085
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.0222 0.0471
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0501
Schistosoma mansoni biogenic amine receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi beta-lactamase family protein 0.0037 0.0104 0.0501
Onchocerca volvulus 0.0104 0.0379 0.2247
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0037 0.0104 0.0615
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.0554 0.0523
Brugia malayi G protein-coupled receptor 0.0281 0.1102 0.5318
Echinococcus granulosus Chromobox protein 3 0.0012 0.00000001618 0.000000034389
Loa Loa (eye worm) hypothetical protein 0.0056 0.0181 0.0873
Brugia malayi Serotonin receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Schistosoma mansoni hypothetical protein 0.0175 0.0667 0.1417
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0013 0.0007 0.0015
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0005 0.0025
Brugia malayi hypoxia-induced factor 1 0.0155 0.0587 0.2833
Onchocerca volvulus 0.0281 0.1102 0.653
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0147 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0132 0.0734
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0034 0.009 0.0191
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Schistosoma mansoni hypothetical protein 0.0026 0.0058 0.0123
Loa Loa (eye worm) hypothetical protein 0.0028 0.0066 0.0317
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0281 0.1102 0.2342
Schistosoma mansoni sodium/chloride dependent transporter 0.0108 0.0392 0.0833
Giardia lamblia DNA damage repair protein 0.0017 0.0022 0.0061
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0066 0.0222 0.107
Echinococcus multilocularis g protein coupled receptor 0.0281 0.1102 0.2342
Echinococcus granulosus single minded 2 0.0039 0.0113 0.024
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0104 0.0221
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.1185 1
Echinococcus multilocularis neuropeptide receptor 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0034 0.009 0.0532
Echinococcus multilocularis g protein coupled receptor 0.0281 0.1102 0.2342
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0104 0.0071
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0063 0.0133
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi cytochrome P450 0.002 0.0033 0.0159
Schistosoma mansoni hypothetical protein 0.0056 0.0181 0.0385
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0281 0.1102 0.5318
Trypanosoma brucei unspecified product 0.0038 0.0107 0.2175
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0025 0.0053 0.0113
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.0102 0.0569
Echinococcus multilocularis neurogenic locus protein delta 0.0039 0.0113 0.024
Mycobacterium ulcerans beta-lactamase 0.0037 0.0104 0.0082
Brugia malayi Cadherin domain containing protein 0.0039 0.0113 0.0546
Mycobacterium ulcerans hypothetical protein 0.045 0.1794 0.1777
Echinococcus multilocularis fat cadherin tumor suppressor 0.0039 0.0113 0.024
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0281 0.1102 0.653
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0013 0.0062
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0015 0.0087
Echinococcus granulosus expressed protein 0.0025 0.0055 0.0118
Schistosoma mansoni hypothetical protein 0.0026 0.0058 0.0123
Loa Loa (eye worm) hypothetical protein 0.0244 0.0949 0.4581
Entamoeba histolytica hypothetical protein 0.0063 0.021 0.1769
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0047 0.0277
Echinococcus granulosus GTP binding nuclear protein Ran 0.0015 0.0015 0.0031
Echinococcus multilocularis dnaJ subfamily B 0.0422 0.1677 0.3565
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.002 0.0033 0.0011
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0104 0.6001
Mycobacterium ulcerans hypothetical protein 0.0037 0.0104 0.0082
Brugia malayi Calcitonin receptor-like protein seb-1 0.0082 0.0287 0.1385
Schistosoma mansoni neuropeptide F-like receptor 0.0281 0.1102 0.2342
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.002 0.0033 0.0011
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0128 0.2666
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Loa Loa (eye worm) animal heme peroxidase 0.0281 0.1102 0.5316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Brugia malayi Tachykinin-like peptides receptor 99D 0.0281 0.1102 0.5318
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.2457 1 1
Brugia malayi RE15519p 0.0281 0.1102 0.5318
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0056 0.018 0.0867
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.2457 1 0.5
Loa Loa (eye worm) animal heme peroxidase 0.0281 0.1102 0.5316
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0022 0.0379
Leishmania major GTP-binding protein, putative 0.0015 0.0015 0.0215
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.009 0.0191
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.002 0.0033 0.0011
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0281 0.1102 0.2342
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.002 0.0033 0.0011
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0063 0.021 0.0446
Loa Loa (eye worm) hypothetical protein 0.0108 0.0392 0.1891
Brugia malayi Cadherin domain containing protein 0.0039 0.0113 0.0546
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus neuropeptides capa receptor 0.0281 0.1102 0.2342
Schistosoma mansoni amine GPCR 0.0281 0.1102 0.2342
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0104 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0104 0.0501
Entamoeba histolytica hypothetical protein 0.0063 0.021 0.1769
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0005 0.0031
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0063 0.021 0.0446
Echinococcus granulosus 7tm_1 domain containing protein 0.0281 0.1102 0.2342
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0132 0.0734
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0054 0.0173 0.0835
Onchocerca volvulus 0.0034 0.009 0.0532
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.002 0.0033 0.0011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0066 0.0222 0.0471
Schistosoma mansoni cpg binding protein 0.0031 0.008 0.017
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0025 0.0053 0.0447
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0237 0.0922 0.0892
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0013 0.0028
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0034 0.009 0.0191
Loa Loa (eye worm) melatonin receptor type 1A 0.0281 0.1102 0.5318
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0281 0.1102 0.2342
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0022 0.0167
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.024 0.051
Leishmania major protein kinase, putative 0.0016 0.0019 0.0309
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0147 0.3268
Mycobacterium tuberculosis Conserved hypothetical protein 0.045 0.1794 0.1767
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0037 0.053
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0022 0.0167
Echinococcus multilocularis importin subunit beta 1 0.0021 0.0037 0.0079
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0281 0.1102 0.2342
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0119 0.0439 0.0933
Echinococcus multilocularis fmrfamide receptor 0.0281 0.1102 0.2342
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0015 0.0015 0.0031
Schistosoma mansoni hypothetical protein 0.0021 0.0039 0.0084
Onchocerca volvulus Peroxidase homolog 0.0281 0.1102 0.6528
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.0177 0.0852
Echinococcus granulosus tm gpcr rhodopsin 0.0281 0.1102 0.2342
Echinococcus multilocularis peroxidasin 0.0281 0.1102 0.2341
Schistosoma mansoni DNA polymerase eta 0.0075 0.0257 0.0547
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0119 0.0439 0.0933
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0025
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.002 0.0033 0.0011
Echinococcus multilocularis g-protein coupled receptor 0.0281 0.1102 0.2342
Echinococcus granulosus tachykinin peptides receptor 99D 0.0281 0.1102 0.2342
Schistosoma mansoni laminin gamma-3 chain 0.0039 0.0113 0.024
Loa Loa (eye worm) hypothetical protein 0.0026 0.0058 0.028
Echinococcus granulosus 7TM GPCR rhodopsin 0.0281 0.1102 0.2342
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0197 0.0165
Echinococcus granulosus histone acetyltransferase KAT2B 0.0145 0.0546 0.1161
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Onchocerca volvulus Peroxidasin homolog 0.0281 0.1102 0.6528
Echinococcus granulosus neuropeptide s receptor 0.0281 0.1102 0.2342
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0104 0.0615
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0119 0.0439 0.2118
Toxoplasma gondii ABC1 family protein 0.0037 0.0104 0.0578
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.002 0.0033 0.0011
Trichomonas vaginalis adenylate cyclase, putative 0.0013 0.0005 0.0031
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0104 0.0071
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0108 0.0392 0.1891
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0039 0.0113 0.067
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0128 0.2666
Brugia malayi M-phase phosphoprotein, mpp8 0.0104 0.0379 0.1829
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.009 0.0191
Echinococcus granulosus dnaJ subfamily B 0.0422 0.1677 0.3565
Echinococcus granulosus g-protein coupled receptor 0.0281 0.1102 0.2342
Brugia malayi Muscle positioning protein 4 0.0039 0.0113 0.0546
Echinococcus granulosus peroxidasin 0.0281 0.1102 0.2341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Schistosoma mansoni slit 0.0039 0.0113 0.024
Loa Loa (eye worm) solute carrier family 6 member 4 0.0111 0.0407 0.1966
Brugia malayi Serotonin receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0154 0.0582 0.2809
Echinococcus granulosus p2X purinoceptor 4 0.1162 0.4705 1
Brugia malayi Dopamine receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0026 0.0058 0.0123
Schistosoma mansoni notch 0.0039 0.0113 0.024
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0119 0.0439 1
Echinococcus granulosus g protein coupled receptor 0.0281 0.1102 0.2342
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0281 0.1102 0.2342
Brugia malayi Animal haem peroxidase family protein 0.0281 0.1102 0.5316
Echinococcus granulosus protein jagged 2 0.0039 0.0113 0.024
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0025 0.0053 0.0258
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0281 0.1102 0.2342
Schistosoma mansoni notch 0.0039 0.0113 0.024
Leishmania major cytochrome p450-like protein 0.002 0.0033 0.0639
Schistosoma mansoni P2X receptor subunit 0.1162 0.4705 1
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus lamin 0.0028 0.0066 0.014
Schistosoma mansoni biogenic amine (5HT) receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0023
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0281 0.1102 0.5318
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0022 0.0046
Echinococcus multilocularis serotonin receptor 0.0281 0.1102 0.2342
Echinococcus granulosus neurogenic locus notch protein 4 0.0039 0.0113 0.024
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0034 0.009 0.0191
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0155 0.075
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0384 0.0816
Echinococcus multilocularis p2X purinoceptor 4 0.1162 0.4705 1
Echinococcus multilocularis fibropellin Ia 0.0039 0.0113 0.024
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.009 0.0191
Toxoplasma gondii EGF family domain-containing protein 0.0039 0.0113 0.063
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0022 0.0167
Echinococcus granulosus G protein coupled receptor 139 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0281 0.1102 0.653
Schistosoma mansoni hypothetical protein 0.0281 0.1102 0.2342
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0104 0.2102
Onchocerca volvulus 0.0281 0.1102 0.653
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Brugia malayi hypothetical protein 0.0244 0.0949 0.4581
Echinococcus granulosus fmrfamide receptor 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0281 0.1102 0.653
Echinococcus multilocularis neuropeptide receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Echinococcus granulosus neurogenic locus notch protein 0.0039 0.0113 0.024
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0025 0.0055 0.0267
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.009 0.05
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0104 0.0615
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0013 0.0062
Trypanosoma brucei DNA polymerase IV, putative 0.007 0.024 0.5307
Schistosoma mansoni notch 0.0039 0.0113 0.024
Entamoeba histolytica hypothetical protein 0.0063 0.021 0.1769
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.0554 0.0534
Giardia lamblia DINP protein human, muc B family 0.006 0.0197 0.1563
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0119 0.0439 1
Schistosoma mansoni hypothetical protein 0.0222 0.0861 0.183
Onchocerca volvulus 0.0281 0.1102 0.653
Echinococcus granulosus allatostatin A receptor 0.0281 0.1102 0.2342
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.009 0.0433
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.002 0.0033 0.0011
Brugia malayi Pre-SET motif family protein 0.0373 0.1477 0.7128
Brugia malayi intermediate filament protein 0.0028 0.0066 0.0317
Onchocerca volvulus 0.0037 0.0104 0.0615
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0261 0.5889
Echinococcus multilocularis dro:myosuppressin receptor 0.0281 0.1102 0.2342
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0384 0.0816
Echinococcus granulosus fibropellin Ia 0.0039 0.0113 0.024
Toxoplasma gondii peptidylprolyl isomerase 0.0025 0.0053 0.0295
Echinococcus granulosus dna polymerase kappa 0.0075 0.0261 0.0554
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0066 0.0317
Echinococcus granulosus neuropeptide receptor 0.0281 0.1102 0.2342
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.002 0.0033 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0022 0.0379
Loa Loa (eye worm) neuropeptide F receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) neuropeptide F receptor 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0424 0.1687 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0021 0.0124
Loa Loa (eye worm) beta-lactamase 0.0037 0.0104 0.0501
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus transcription factor Dp 1 0.0069 0.0234 0.0497
Schistosoma mansoni notch 0.0039 0.0113 0.024
Onchocerca volvulus 0.0281 0.1102 0.653
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0027 0.0163
Leishmania major lanosterol 14-alpha-demethylase, putative 0.002 0.0033 0.0639
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0384 0.0816
Trichomonas vaginalis ran, putative 0.0015 0.0015 0.0086
Echinococcus multilocularis serotonin transporter 0.0111 0.0407 0.0866
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0373 0.1477 0.7128
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0022 0.1473
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0025 0.0053 0.11
Schistosoma mansoni ran 0.0015 0.0015 0.0031
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0025 0.0053 0.0113
Schistosoma mansoni amine GPCR 0.0281 0.1102 0.2342
Schistosoma mansoni cpg binding protein 0.003 0.0073 0.0155
Schistosoma mansoni amine GPCR 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0179
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.002 0.0033 0.0011
Onchocerca volvulus 0.0281 0.1102 0.653
Toxoplasma gondii cytochrome p450 superfamily protein 0.002 0.0033 0.0184
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0104 0.0071
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0108 0.0392 0.1891
Trypanosoma brucei DNA polymerase eta, putative 0.0075 0.0257 0.5715
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Toxoplasma gondii histone lysine methyltransferase SET1 0.0062 0.0204 0.1139
Loa Loa (eye worm) animal heme peroxidase 0.0281 0.1102 0.5316
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0113 0.0546
Trypanosoma brucei importin beta-1 subunit, putative 0.0021 0.0037 0.053
Echinococcus multilocularis orexin receptor type 2 0.0281 0.1102 0.2342
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0281 0.1102 0.2342
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0104 0.0099
Schistosoma mansoni lamin 0.0028 0.0066 0.014
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus neuropeptide FF receptor 2 0.0281 0.1102 0.2342
Trichomonas vaginalis importin beta-1, putative 0.0017 0.0021 0.0124
Brugia malayi CXXC zinc finger family protein 0.003 0.0073 0.0352
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Echinococcus granulosus neurogenic locus protein delta 0.0039 0.0113 0.024
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0022 0.0167
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.009 0.05
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0066 0.0221 0.047
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Onchocerca volvulus Putative cubilin 0.0039 0.0113 0.067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0281 0.1102 0.2342
Schistosoma mansoni hypothetical protein 0.0281 0.1102 0.2342
Schistosoma mansoni single-minded 0.005 0.0157 0.0334
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Echinococcus multilocularis lamin dm0 0.0028 0.0066 0.014
Schistosoma mansoni hypothetical protein 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0281 0.1102 0.653
Schistosoma mansoni biogenic amine (5HT) receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0518 0.2072 1
Leishmania major cytochrome p450-like protein 0.0031 0.0078 0.1686
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.002 0.0033 0.0011
Echinococcus granulosus dna polymerase eta 0.0075 0.0257 0.0547
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0104 0.0221
Echinococcus multilocularis neuropeptide FF receptor 2 0.0281 0.1102 0.2342
Mycobacterium ulcerans hypothetical protein 0.045 0.1794 0.1777
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0013 0.0005 0.0031
Trypanosoma brucei PAB1-binding protein , putative 0.0048 0.0147 0.312
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Echinococcus multilocularis p2X purinoceptor 4 0.1162 0.4705 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0021 0.0039 0.0084
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0104 0.2272
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0022 0.0042 0.0237
Leishmania major DNA polymerase eta, putative 0.0037 0.0102 0.2235
Schistosoma mansoni opsin-like receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0093 0.0331 0.0704
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0281 0.1102 0.2342
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.045 0.1794 1
Brugia malayi G-protein coupled receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Echinococcus multilocularis serotonin receptor 0.0281 0.1102 0.2342
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0301 0.1185 1
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0039 0.0113 0.024
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0281 0.1102 0.2342
Echinococcus multilocularis neurogenic locus notch protein 4 0.0039 0.0113 0.024
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0501
Treponema pallidum licC protein (licC) 0.045 0.1794 1
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0119 0.0439 1
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0106 0.0384 0.0816
Mycobacterium ulcerans DNA polymerase IV 0.0075 0.0261 0.024
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0021 0.0039 0.0084
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypoxia-induced factor 1 0.0155 0.0587 0.2833
Schistosoma mansoni neuropeptide f receptor 76f 0.0281 0.1102 0.2342
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0104 0.0082
Echinococcus granulosus sodium and chloride dependent glycine 0.0108 0.0392 0.0833
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis sodium and chloride dependent glycine 0.0108 0.0392 0.0833
Loa Loa (eye worm) acetyltransferase 0.0149 0.0563 0.2718
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0281 0.1102 0.2342
Brugia malayi polk-prov protein 0.0038 0.0106 0.051
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0015 0.0015 0.007
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0104 0.0615
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0111 0.0407 0.1966
Echinococcus multilocularis protein jagged 1 0.0039 0.0113 0.024
Echinococcus granulosus lamin dm0 0.0028 0.0066 0.014
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0015 0.0015 0.0991
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0022 0.0121
Echinococcus multilocularis neuropeptide receptor A26 0.0281 0.1102 0.2342
Toxoplasma gondii melibiase subfamily protein 0.0106 0.0384 0.214
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0132 0.7615
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.009 0.0191
Schistosoma mansoni importin beta-1 0.0021 0.0037 0.0079
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Schistosoma mansoni amine GPCR 0.0281 0.1102 0.2342
Echinococcus multilocularis musashi 0.0028 0.0066 0.014
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0433
Echinococcus multilocularis g protein coupled receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0063 0.0211 0.1019
Onchocerca volvulus Dual oxidase homolog 0.0281 0.1102 0.6528
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0005 0.0011
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0013 0.0005 0.0031
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0034 0.009 0.0433
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0034 0.009 0.0191
Loa Loa (eye worm) hypothetical protein 0.0111 0.0407 0.1966
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0128 0.2666
Loa Loa (eye worm) hypothetical protein 0.0075 0.0257 0.1241
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0063 0.0211 0.0449
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0082 0.0287 0.1385
Brugia malayi SET domain containing protein 0.0014 0.0011 0.0052
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0034 0.009 0.0191
Echinococcus granulosus neuropeptide receptor 0.0281 0.1102 0.2342
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0034 0.009 0.0191
Brugia malayi Latrophilin receptor protein 2 0.0026 0.0058 0.028
Schistosoma mansoni microtubule-associated protein tau 0.0712 0.2863 0.6085
Schistosoma mansoni hypothetical protein 0.0175 0.0667 0.1417
Schistosoma mansoni adenoreceptor 0.0281 0.1102 0.2342
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0039 0.0113 0.0546
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Brugia malayi Animal haem peroxidase family protein 0.0281 0.1102 0.5316
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0281 0.1102 0.2342
Echinococcus granulosus intermediate filament protein 0.0028 0.0066 0.014
Onchocerca volvulus 0.0111 0.0407 0.2414
Brugia malayi Animal haem peroxidase family protein 0.0281 0.1102 0.5316
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0281 0.1102 0.653
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0104 0.0221
Loa Loa (eye worm) hypothetical protein 0.0104 0.0379 0.1829
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0093 0.0331 0.0704
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0066 0.0222 0.0471
Echinococcus multilocularis neuropeptides capa receptor 0.0281 0.1102 0.2342
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0132 0.078
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0023 0.0047 0.0277
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0281 0.1102 0.2342
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0027 0.0163
Entamoeba histolytica Ran family GTPase 0.0015 0.0015 0.0123
Echinococcus granulosus protein jagged 1 0.0039 0.0113 0.024
Onchocerca volvulus 0.0281 0.1102 0.653
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0163
Brugia malayi Pre-SET motif family protein 0.0054 0.0173 0.0835
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0055 0.0328
Leishmania major DNA polymerase kappa, putative 0.006 0.0197 0.4432
Toxoplasma gondii hypothetical protein 0.0034 0.009 0.05
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0054 0.0173 0.0368
Onchocerca volvulus Peroxidase homolog 0.0281 0.1102 0.6528
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0281 0.1102 0.2342
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0173 0.0368
Brugia malayi CHD4 protein 0.0013 0.0007 0.0033
Echinococcus granulosus serotonin transporter 0.0111 0.0407 0.0866
Brugia malayi Cytochrome P450 family protein 0.002 0.0033 0.0159
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0033
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0173 0.0368
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0034 0.009 0.0433
Brugia malayi Muscleblind-like protein 0.0154 0.0582 0.2809
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0034 0.009 0.05
Schistosoma mansoni P2X receptor subunit 0.1162 0.4705 1
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Echinococcus granulosus dro:myosuppressin receptor 0.0281 0.1102 0.2342
Echinococcus multilocularis sodium and chloride dependent glycine 0.0108 0.0392 0.0833
Onchocerca volvulus Neurogenic locus notch homolog 0.0039 0.0113 0.067
Trypanosoma brucei unspecified product 0.007 0.024 0.5307
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0104 0.0071
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0013 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0023
Schistosoma mansoni peroxidasin 0.0281 0.1102 0.2341
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0063 0.0211 0.0449
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) latrophilin receptor protein 2 0.0026 0.0058 0.028
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0582 0.1237
Echinococcus multilocularis transcription factor Dp 1 0.0069 0.0234 0.0497
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0017 0.0021 0.0124
Echinococcus multilocularis aryl hydrocarbon receptor 0.0013 0.0005 0.0011
Schistosoma mansoni hypothetical protein 0.0026 0.0058 0.0123
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.002 0.0033 0.0011
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0104 0.2272
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0056 0.018 0.0382
Brugia malayi Dopamine receptor protein 1 0.0281 0.1102 0.5318
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0054 0.0173 0.0368
Echinococcus granulosus neuropeptides capa receptor 0.0281 0.1102 0.2342
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.002 0.0033 0.0011
Brugia malayi latrophilin 2 splice variant baaae 0.0056 0.0181 0.0873
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0104 0.0221
Giardia lamblia Fructose-bisphosphate aldolase 0.0301 0.1185 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Echinococcus granulosus sodium and chloride dependent glycine 0.0108 0.0392 0.0833
Onchocerca volvulus 0.0281 0.1102 0.653
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Trypanosoma brucei DNA polymerase kappa, putative 0.0038 0.0106 0.2147
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0015 0.0015 0.0081
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0054 0.0173 0.0368
Brugia malayi Blistered cuticle protein 3 0.0281 0.1102 0.5316
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.002 0.0033 0.0011
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0013 0.0007 0.0015
Schistosoma mansoni hypothetical protein 0.0422 0.1677 0.3565
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0281 0.1102 0.2342
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.007 0.024 0.051
Brugia malayi Cytochrome P450 family protein 0.0031 0.0078 0.0378
Echinococcus multilocularis muscleblind protein 0.0154 0.0582 0.1237
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0007 0.0014
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0025 0.0053 0.11
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0093 0.0331 0.0704
Brugia malayi putative neuropeptide receptor NPR1 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0281 0.1102 0.6528
Loa Loa (eye worm) hypothetical protein 0.0154 0.0582 0.2809
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0.0007 0.0033
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0034 0.009 0.0191
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0104 0.0071
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0015 0.0015 0.007
Mycobacterium ulcerans lipase LipD 0.0037 0.0104 0.0082
Loa Loa (eye worm) animal heme peroxidase 0.0281 0.1102 0.5316
Echinococcus granulosus neuropeptide receptor A26 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Plasmodium vivax hypothetical protein, conserved 0.0034 0.009 0.5193
Echinococcus granulosus peptide allatostatin:somatostatin 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0013 0.0005 0.0031
Onchocerca volvulus 0.0281 0.1102 0.6528
Echinococcus multilocularis fmrfamide receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Plasmodium falciparum ataxin-2 like protein, putative 0.0048 0.0147 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Onchocerca volvulus 0.0066 0.0221 0.131
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0163
Loa Loa (eye worm) hypothetical protein 0.0104 0.0379 0.1829
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Schistosoma mansoni neuropeptide receptor 0.0281 0.1102 0.2342
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0015 0.0015 0.0215
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0163
Loa Loa (eye worm) norepinephrine transporter 0.0111 0.0407 0.1966
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0051 0.0162 0.0345
Loa Loa (eye worm) hypothetical protein 0.0048 0.0147 0.0709
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0261 0.5799
Schistosoma mansoni neuropeptide F-like receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Entamoeba histolytica hypothetical protein 0.0017 0.0021 0.0177
Brugia malayi hypothetical protein 0.0281 0.1102 0.5316
Schistosoma mansoni biogenic amine receptor 0.0281 0.1102 0.2342
Mycobacterium leprae Probable lipase LipE 0.0037 0.0104 0.0099
Schistosoma mansoni cytochrome P450 0.002 0.0033 0.007
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0025 0.0053 0.0258
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0066 0.0222 0.0471
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0026 0.0058 0.0123
Brugia malayi Importin beta-1 subunit 0.0021 0.0037 0.0179
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0111 0.0407 0.0866
Schistosoma mansoni cell polarity protein 0.0039 0.0113 0.024
Echinococcus granulosus delta-like protein 1 0.0039 0.0113 0.024
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0033 0.0639
Loa Loa (eye worm) Notch2 0.0039 0.0113 0.0546
Echinococcus granulosus somatostatin receptor 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0039 0.0113 0.067
Echinococcus multilocularis G protein coupled receptor 139 0.0281 0.1102 0.2342
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.002 0.0033 0.0434
Echinococcus multilocularis GPCR, family 2 0.0026 0.0058 0.0123
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0022 0.0379
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0197 0.431
Trypanosoma cruzi DNA polymerase kappa, putative 0.0075 0.0261 0.5889
Echinococcus granulosus GPCR family 2 0.0026 0.0058 0.0123
Schistosoma mansoni voltage-gated potassium channel 0.0027 0.0063 0.0133
Schistosoma mansoni myosin xvIII 0.0281 0.1102 0.2342
Loa Loa (eye worm) serotonin transporter b 0.0111 0.0407 0.1966
Trypanosoma brucei cytochrome P450, putative 0.0031 0.0078 0.1503
Entamoeba histolytica hypothetical protein 0.0063 0.021 0.1769
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0281 0.1102 0.2342
Brugia malayi hypothetical protein 0.0104 0.0379 0.1829
Onchocerca volvulus 0.0039 0.0113 0.067
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0281 0.1102 0.2342
Plasmodium vivax amine transporter, putative 0.0034 0.009 0.5193
Toxoplasma gondii HEAT repeat-containing protein 0.0021 0.0037 0.0206
Schistosoma mansoni alpha-1 adrenergic receptor 0.0281 0.1102 0.2342
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0177 0.0144
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0073 0.0352
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.002 0.0033 0.0011
Leishmania major DNA polymerase kappa, putative 0.0017 0.0022 0.0379
Brugia malayi ORL1-like opioid receptor 0.0281 0.1102 0.5318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0027 0.0163
Schistosoma mansoni growth hormone secretagogue receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0119 0.0439 0.0933
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.0177 0.0375
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0034 0.009 0.0191
Brugia malayi follicle stimulating hormone receptor 0.0518 0.2072 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0106 0.0384 0.0816
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.0177 0.0852
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Echinococcus granulosus p2X purinoceptor 4 0.1162 0.4705 1
Brugia malayi GnHR receptor homolog 0.0281 0.1102 0.5318
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0301 0.1185 0.7021
Echinococcus granulosus biogenic amine 5HT receptor 0.0281 0.1102 0.2342
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0063 0.0211 0.1681
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0281 0.1102 0.5318
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0261 0.5799
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0281 0.1102 0.2342
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Onchocerca volvulus Neuropeptide F receptor homolog 0.0281 0.1102 0.653
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0281 0.1102 0.2342
Echinococcus multilocularis somatostatin receptor 0.0281 0.1102 0.2342
Brugia malayi Melatonin receptor type 1A 0.0281 0.1102 0.5318
Onchocerca volvulus 0.0028 0.0066 0.0389
Loa Loa (eye worm) hypothetical protein 0.0034 0.009 0.0433
Schistosoma mansoni amine GPCR 0.0281 0.1102 0.2342
Plasmodium vivax SET domain protein, putative 0.0054 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Brugia malayi AKH receptor 0.0281 0.1102 0.5318
Echinococcus multilocularis neuropeptide Y receptor 0.0281 0.1102 0.2342
Schistosoma mansoni notch 0.0039 0.0113 0.024
Echinococcus granulosus microtubule associated protein 2 0.0712 0.2863 0.6085
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0501
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0281 0.1102 0.5318
Echinococcus multilocularis G-protein coupled receptor, putative 0.0281 0.1102 0.2342
Brugia malayi hypothetical protein 0.0031 0.0078 0.0376
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Echinococcus granulosus neural cadherin 0.0039 0.0113 0.024
Onchocerca volvulus 0.0281 0.1102 0.653
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Echinococcus multilocularis expressed protein 0.0025 0.0055 0.0118
Echinococcus multilocularis rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Onchocerca volvulus 0.0034 0.009 0.0532
Schistosoma mansoni notch 0.0039 0.0113 0.024
Trypanosoma cruzi cytochrome p450-like protein, putative 0.002 0.0033 0.0639
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0056 0.018 0.0867
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0501
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Schistosoma mansoni sodium/chloride dependent transporter 0.0111 0.0407 0.0866
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0104 0.0082
Loa Loa (eye worm) hypothetical protein 0.0037 0.0104 0.0501
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0031 0.0078 0.0057
Loa Loa (eye worm) cytochrome P450 family protein 0.0083 0.0291 0.1403
Onchocerca volvulus 0.0281 0.1102 0.6528
Brugia malayi G-protein coupled receptor 0.0281 0.1102 0.5318
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0015 0.0013 0.0075
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0013 0.0073
Schistosoma mansoni P2X receptor subunit 0.0512 0.2045 0.4346
Brugia malayi Calcium binding EGF domain containing protein 0.0039 0.0113 0.0546
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0281 0.1102 0.5318
Schistosoma mansoni hypothetical protein 0.0281 0.1102 0.2342
Plasmodium falciparum transporter, putative 0.0034 0.009 0.6111
Giardia lamblia Histone acetyltransferase GCN5 0.004 0.0117 0.0873
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.0147 0.3268
Brugia malayi EGF-like domain containing protein 0.0039 0.0113 0.0546
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0281 0.1102 0.2342
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0034 0.009 0.0433
Echinococcus granulosus biogenic amine 5HT receptor 0.0281 0.1102 0.2342
Onchocerca volvulus 0.003 0.0073 0.0433
Brugia malayi hypothetical protein 0.0281 0.1102 0.5318
Echinococcus multilocularis survival motor neuron protein 1 0.0244 0.0949 0.2018
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0005 0.0031
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) G-protein coupled receptor 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Onchocerca volvulus 0.0039 0.0113 0.067
Schistosoma mansoni septate junction protein 0.0039 0.0113 0.024
Trichomonas vaginalis DNA polymerase eta, putative 0.0075 0.0261 0.1545
Trypanosoma brucei DNA polymerase kappa, putative 0.0075 0.0261 0.5799
Echinococcus granulosus orexin receptor type 2 0.0281 0.1102 0.2342
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.007 0.024 0.1422
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0015 0.0087
Leishmania major importin beta-1 subunit, putative 0.0017 0.0021 0.0362
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Echinococcus granulosus alpha 1A adrenergic receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.045 0.1794 0.1777
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.0177 0.0375
Schistosoma mansoni hypothetical protein 0.0039 0.0113 0.024
Onchocerca volvulus Peroxidasin homolog 0.0281 0.1102 0.6528
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0034 0.009 0.0191
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0054 0.0173 0.0964
Toxoplasma gondii hypothetical protein 0.0034 0.009 0.05
Echinococcus multilocularis Chromobox protein 3 0.0012 0.00000001618 0.000000034389
Loa Loa (eye worm) hypothetical protein 0.0039 0.0113 0.0546
Schistosoma mansoni peroxidasin 0.0281 0.1102 0.2341
Echinococcus granulosus neurogenic locus notch protein 0.0039 0.0113 0.024
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.0177 0.0375
Echinococcus multilocularis allatostatin A receptor 0.0281 0.1102 0.2342
Loa Loa (eye worm) cytochrome P450 family protein 0.0031 0.0078 0.0378
Trichomonas vaginalis guanylate cyclase, putative 0.0013 0.0005 0.0031
Schistosoma mansoni opsin-like receptor 0.0281 0.1102 0.2342
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.002 0.0033 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Echinococcus granulosus rhodopsin orphan GPCR 0.0281 0.1102 0.2342
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5316
Loa Loa (eye worm) hypothetical protein 0.0281 0.1102 0.5318
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0119 0.0439 1
Schistosoma mansoni hypothetical protein 0.005 0.0155 0.033
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0197 0.4432
Brugia malayi hypothetical protein 0.0048 0.0147 0.0709
Echinococcus granulosus p2X purinoceptor 4 0.1162 0.4705 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0281 0.1102 0.2342
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.002 0.0033 0.0639
Entamoeba histolytica acetyltransferase, GNAT family 0.004 0.0117 0.0985
Plasmodium falciparum importin beta, putative 0.0021 0.0037 0.2521

Activities

Activity type Activity value Assay description Source Reference
Ratio (functional) = 5 Ratio of maximum plasma concentration (C) measured ex vivo to that of IC50 of (10a or 10c) in rat treated intravenously with 10 mg/kg ChEMBL. 8120868

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.