Detailed information for compound 28886

Basic information

Technical information
  • TDR Targets ID: 28886
  • Name: 2-[[(1R,2S)-2-[(3,4-dichlorophenyl)methylamin o]cyclopentyl]methylamino]-1H-quinolin-4-one
  • MW: 416.344 | Formula: C22H23Cl2N3O
  • H donors: 3 H acceptors: 2 LogP: 5.64 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1Cl)CN[C@H]1CCC[C@@H]1CNc1cc(O)c2c(n1)cccc2
  • InChi: 1S/C22H23Cl2N3O/c23-17-9-8-14(10-18(17)24)12-25-19-7-3-4-15(19)13-26-22-11-21(28)16-5-1-2-6-20(16)27-22/h1-2,5-6,8-11,15,19,25H,3-4,7,12-13H2,(H2,26,27,28)/t15-,19+/m1/s1
  • InChiKey: GQAWHFHCJXEXAJ-BEFAXECRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[(1R,2S)-2-[(3,4-dichlorobenzyl)amino]cyclopentyl]methylamino]-4-quinolone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0029 0.0097 0.0232
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0709 0.4911 1
Brugia malayi ImpB/MucB/SamB family protein 0.0081 0.0466 0.0786
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Toxoplasma gondii cathepsin CPC2 0.0026 0.0074 0.039
Echinococcus granulosus Myosin regulatory light chain 0.0025 0.0068 0.0068
Echinococcus granulosus serine:threonine protein kinase NLK 0.0028 0.0092 0.0092
Echinococcus granulosus Calcium binding protein 0.0025 0.0068 0.0068
Plasmodium falciparum serine repeat antigen 5 0.0026 0.0074 0.1624
Trypanosoma brucei cysteine peptidase C (CPC) 0.0282 0.1887 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0012 0.003
Echinococcus multilocularis programmed cell death protein 0.0054 0.0272 0.0272
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Giardia lamblia DNA damage repair protein 0.0017 0.0013 0.003
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Echinococcus granulosus neuropeptide s receptor 0.048 0.329 0.329
Leishmania major calmodulin, putative 0.0029 0.0097 0.0513
Toxoplasma gondii preprocathepsin c precursor, putative 0.0026 0.0074 0.039
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0163 0.0333
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0197
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0012 0.0088
Trypanosoma brucei mitochondrial calcium uptake 1 0.0029 0.0097 0.0513
Echinococcus granulosus calumenin 0.0029 0.0097 0.0097
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0012 0.0066
Trypanosoma cruzi kinesin, putative 0.0149 0.0949 0.1598
Echinococcus granulosus lamin 0.0028 0.0089 0.0089
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0475 0.0799
Trichomonas vaginalis bollus pemphigoid antigen, putative 0.0025 0.0068 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Loa Loa (eye worm) glutathione reductase 0.0049 0.0239 0.0403
Plasmodium falciparum centrin-4 0.0025 0.0068 0.1495
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.7435
Schistosoma mansoni lamin 0.0028 0.0089 0.0089
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0178 0.0745
Treponema pallidum penicillin-binding protein (pbp-3) 0.0873 0.6067 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis calmodulin, putative 0.0025 0.0068 0.0162
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0026 0.0074 0.1624
Brugia malayi cathepsin B-like cysteine proteinase 0.0854 0.5936 1
Leishmania major centrin, putative,caltractin, putative 0.0029 0.0097 0.0513
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Loa Loa (eye worm) thioredoxin reductase 0.0049 0.0239 0.0403
Trichomonas vaginalis myosin light chain 1, putative 0.0029 0.0097 0.0232
Echinococcus granulosus calpain A 0.0595 0.4101 0.4101
Schistosoma mansoni pyruvate kinase 0.0034 0.0136 0.0136
Giardia lamblia Kinase, CAMK CAMKL 0.0028 0.0092 0.022
Schistosoma mansoni flap endonuclease-1 0.0024 0.0065 0.0065
Echinococcus granulosus calbindin 32 0.0029 0.0097 0.0097
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0455 0.3108 0.6345
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0064 0.0346 0.083
Echinococcus multilocularis calpain 5 0.0213 0.1403 0.1403
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.1403 0.2363
Loa Loa (eye worm) calpain family protein 1 0.0417 0.284 0.4784
Leishmania major centrin, putative 0.0029 0.0097 0.0513
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.0163
Chlamydia trachomatis transglycolase/transpeptidase 0.035 0.2367 0.4807
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0026 0.0074 0.0088
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0605 0.4173 1
Echinococcus multilocularis chromobox protein 1 0.0072 0.0402 0.0402
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0012 0.0025
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0346 0.0583
Trichomonas vaginalis conserved hypothetical protein 0.0064 0.0346 0.083
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0074 0.0074
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0043 0.0199 0.1054
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0111 0.0111
Trichomonas vaginalis calmodulin, putative 0.0054 0.0272 0.0652
Trichomonas vaginalis calmodulin-2, putative 0.0029 0.0097 0.0232
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.042 0.0708
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0029 0.0097 0.0163
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0062
Trypanosoma cruzi DNA polymerase eta, putative 0.0043 0.0199 0.0335
Loa Loa (eye worm) cathepsin B 0.0282 0.1887 0.3178
Leishmania major mitogen-activated protein kinase, putative,map kinase-like protein 0.0028 0.0092 0.0486
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0013 0.0021
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.0105
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0074 0.0176
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.0108 0.0157
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0083 0.014
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis calcium binding proteins, putative 0.0029 0.0097 0.0232
Onchocerca volvulus 0.0026 0.0074 0.0308
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Loa Loa (eye worm) hypothetical protein 0.0854 0.5936 1
Brugia malayi cathepsin Z-like cysteine proteinase 0.0026 0.0074 0.0124
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0021
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.069 0.1578
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0108 0.2379
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0352 0.238 0.6984
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Onchocerca volvulus 0.0026 0.0074 0.0308
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0455 0.3108 0.9121
Trypanosoma cruzi kinesin, putative 0.0149 0.0949 0.1598
Plasmodium falciparum serine repeat antigen 1 0.0026 0.0074 0.1624
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0027 0.0084 0.0084
Brugia malayi glutathione reductase 0.0049 0.0239 0.0403
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0074 0.0074
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.028 0.0472
Echinococcus granulosus cathepsin b 0.0854 0.5936 0.5936
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Trypanosoma brucei cysteine peptidase, putative 0.0064 0.0346 0.1835
Echinococcus granulosus pyruvate kinase 0.0018 0.0017 0.0017
Onchocerca volvulus 0.0246 0.163 0.6832
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0062 0.0105
Loa Loa (eye worm) hypothetical protein 0.0502 0.3442 0.5799
Brugia malayi Pre-SET motif family protein 0.0216 0.1419 0.2391
Trypanosoma cruzi hypothetical protein, conserved 0.0025 0.0068 0.0114
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma brucei calpain-like protein, putative 0.0213 0.1403 0.7435
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0092 0.022
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0037 0.0037
Loa Loa (eye worm) calpain 5 0.0149 0.0949 0.1598
Trypanosoma brucei calpain-like protein, putative 0.0213 0.1403 0.7435
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0037 0.0037
Plasmodium falciparum thioredoxin reductase 0.0017 0.0012 0.0274
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.069 0.1162
Brugia malayi 6-phosphofructokinase 0.0113 0.069 0.1162
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0258
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0112 0.0684 0.1899
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0064 0.0346 0.1835
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0074 0.0176
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0074 0.0074
Giardia lamblia Cathepsin B precursor 0.0026 0.0074 0.0176
Giardia lamblia Hypothetical protein 0.0029 0.0097 0.0232
Brugia malayi beta-lactamase 0.0075 0.042 0.0708
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0074 0.0074
Leishmania major DNA polymerase kappa, putative 0.0017 0.0013 0.0067
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0062 0.0061
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trypanosoma brucei antigen, putative 0.0213 0.1403 0.7435
Plasmodium vivax cyclin dependent kinase 7 (cdk7), putative 0.0028 0.0092 0.0654
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Echinococcus multilocularis musashi 0.0028 0.0089 0.0089
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma cruzi I/6 autoantigen, putative 0.0029 0.0097 0.0163
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0064 0.0346 0.083
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0026 0.0074 0.0524
Plasmodium vivax hypothetical protein, conserved 0.0075 0.042 0.2998
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0074 0.0124
Trypanosoma brucei calpain-like protein, putative 0.0213 0.1403 0.7435
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0074 0.0074
Trichomonas vaginalis kakapo, putative 0.0025 0.0068 0.0162
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0282 0.1887 1
Loa Loa (eye worm) calpain family protein 1 0.0566 0.3896 0.6564
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0352 0.238 0.6902
Echinococcus granulosus dna polymerase eta 0.0081 0.0466 0.0466
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.042 0.1008
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Treponema pallidum penicillin-binding protein (pbp-1) 0.0709 0.4911 0.8091
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0074 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.069 0.1653
Giardia lamblia Cathepsin B precursor 0.0282 0.1887 0.4521
Echinococcus multilocularis dna polymerase eta 0.0081 0.0466 0.0466
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0566 0.3896 0.3896
Brugia malayi Protein kinase domain containing protein 0.0017 0.0015 0.0025
Mycobacterium tuberculosis Probable dehydrogenase 0.0112 0.0684 0.2006
Schistosoma mansoni pyruvate kinase 0.0034 0.0136 0.0136
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0026 0.0074 0.1624
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Schistosoma mansoni kinase 0.0156 0.0995 0.0995
Echinococcus multilocularis expressed protein 0.0035 0.0136 0.0136
Onchocerca volvulus 0.0025 0.0068 0.0284
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Brugia malayi Thioredoxin reductase 0.0049 0.0239 0.0403
Trichomonas vaginalis calcineurin B subunit, putative 0.0029 0.0097 0.0232
Trypanosoma cruzi centrin-3 0.0054 0.0272 0.0459
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.0012 0.003
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni microtubule-associated protein tau 0.1429 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Schistosoma mansoni ef hand domain family member A2 0.0029 0.0097 0.0097
Trichomonas vaginalis calpain, putative 0.0064 0.0346 0.083
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0029 0.0097 0.0163
Leishmania major pyruvate kinase 0.0034 0.0136 0.0721
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Echinococcus granulosus calpain 5 0.0213 0.1403 0.1403
Schistosoma mansoni cathepsin F (C01 family) 0.0026 0.0074 0.0074
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Mycobacterium tuberculosis Conserved protein 0.0075 0.042 0.1234
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0074 0.0176
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.004 0.0166
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0029 0.0097 0.0513
Giardia lamblia Calmodulin 0.0025 0.0068 0.0162
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0163 0.0275
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0166 0.1068 0.3134
Echinococcus multilocularis centrin 2 0.0029 0.0097 0.0097
Onchocerca volvulus 0.0025 0.0068 0.0284
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.0131 0.0692
Trichomonas vaginalis caltractin, putative 0.0025 0.0068 0.0162
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Brugia malayi Heterochromatin protein 1 0.0072 0.0402 0.0676
Toxoplasma gondii ABC1 family protein 0.0075 0.042 0.2229
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.042 0.042
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0103 0.0103
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0013 0.0067
Giardia lamblia Cysteine protease 0.0026 0.0074 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Loa Loa (eye worm) myosin regulatory light chain 1 0.0025 0.0068 0.0114
Loa Loa (eye worm) cysteine protease 0.0026 0.0074 0.0124
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0136 0.0229
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0029 0.0097 0.0097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Onchocerca volvulus 0.0028 0.0089 0.0374
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0021
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0108 0.0194
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0026 0.0074 0.0074
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0111 0.0111
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0012 0.003
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.0108 0.0258
Echinococcus granulosus pyruvate kinase 0.0018 0.0017 0.0017
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0074 0.0124
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0111 0.0589
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.0108 0.2379
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0375 0.0631
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0025
Giardia lamblia Cathepsin L precursor 0.0026 0.0074 0.0176
Leishmania major cysteine peptidase A (CPA) 0.0026 0.0074 0.039
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.028 0.0588
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Echinococcus multilocularis cysteine protease 0.0026 0.0074 0.0074
Schistosoma mansoni chromobox protein 0.0072 0.0402 0.0402
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0312 0.0312
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.7435
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.7435
Loa Loa (eye worm) hypothetical protein 0.0021 0.004 0.0067
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Schistosoma mansoni hypothetical protein 0.0029 0.0097 0.0097
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0217 0.0217
Plasmodium vivax vivapain-2 0.0026 0.0074 0.0524
Trypanosoma brucei calmodulin, putative 0.0029 0.0097 0.0513
Brugia malayi Myosin regulatory light chain 1 0.0025 0.0068 0.0114
Echinococcus granulosus EF hand domain containing family member A2 0.0029 0.0097 0.0097
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0037 0.0062
Brugia malayi cathepsin L-like cysteine proteinase 0.0026 0.0074 0.0124
Brugia malayi programmed cell death protein 6 0.0029 0.0097 0.0163
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0026 0.0074 0.0074
Toxoplasma gondii EF hand domain-containing protein 0.0029 0.0097 0.0513
Loa Loa (eye worm) hypothetical protein 0.0352 0.2386 0.4019
Echinococcus multilocularis calcyphosin protein 0.0025 0.0068 0.0068
Trypanosoma brucei caltractin, putative 0.0054 0.0272 0.1443
Loa Loa (eye worm) hypothetical protein 0.0075 0.042 0.0708
Plasmodium vivax myosin A tail domain interacting protein MTIP, putative 0.0025 0.0068 0.0482
Plasmodium vivax vivapain-1 0.0026 0.0074 0.0524
Schistosoma mansoni neuronal calcium sensor 0.0029 0.0097 0.0097
Leishmania major pyruvate kinase 0.0034 0.0136 0.0721
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0012 0.0025
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Echinococcus multilocularis microtubule associated protein 2 0.1429 1 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Echinococcus granulosus thioredoxin glutathione reductase 0.0049 0.0239 0.0239
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Loa Loa (eye worm) hypothetical protein 0.0031 0.0111 0.0187
Leishmania major hypothetical protein, conserved 0.0075 0.042 0.2229
Echinococcus multilocularis cathepsin b 0.0854 0.5936 0.5936
Schistosoma mansoni hypothetical protein 0.0027 0.0084 0.0084
Schistosoma mansoni cathepsin B (C01 family) 0.0026 0.0074 0.0074
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.0131 0.0692
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0136 0.057
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0163 0.0866
Loa Loa (eye worm) hypothetical protein 0.0075 0.042 0.0708
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Echinococcus granulosus cyclin dependent kinase 9 0.0183 0.1187 0.1187
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0074 0.0308
Entamoeba histolytica hypothetical protein 0.0026 0.0074 0.0088
Plasmodium falciparum serine repeat antigen 9 0.0026 0.0074 0.1624
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0114
Schistosoma mansoni calmodulin 0.0029 0.0097 0.0097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Plasmodium vivax serine/threonine protein kinase KIN, putative 0.0028 0.0092 0.0654
Echinococcus granulosus cathepsin L cysteine proteinase 0.0026 0.0074 0.0074
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma brucei pyruvate kinase 1 0.0034 0.0136 0.0721
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.069 0.1162
Trypanosoma brucei DNA polymerase IV, putative 0.0075 0.0426 0.226
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Brugia malayi Probable myosin regulatory light chain 0.0025 0.0068 0.0114
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0028 0.0092 0.0092
Plasmodium falciparum serine repeat antigen 3 0.0026 0.0074 0.1624
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.042 0.1008
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Loa Loa (eye worm) CMGC/CDK/CDK9 protein kinase 0.0156 0.0995 0.1676
Trypanosoma brucei centrin, putative 0.0029 0.0097 0.0513
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0178 0.0426
Onchocerca volvulus 0.0352 0.2386 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0163 0.3609
Toxoplasma gondii cathepsin CPC1 0.0026 0.0074 0.039
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.042 0.1234
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.3267 0.9588
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Leishmania major kinesin, putative 0.0149 0.0949 0.5028
Leishmania major protein kinase, putative 0.003 0.0104 0.0553
Schistosoma mansoni cathepsin C 0.0026 0.0074 0.0074
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0163 0.0333
Trichomonas vaginalis calcium binding protein, putative 0.0029 0.0097 0.0232
Loa Loa (eye worm) hypothetical protein 0.0017 0.0015 0.0025
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Entamoeba histolytica grainin 2 0.0054 0.0272 0.0569
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0296 0.1983 0.5821
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0064 0.0346 0.083
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0026 0.0074 0.0524
Echinococcus granulosus neuronal calcium sensor 0.0029 0.0097 0.0097
Plasmodium vivax serine-repeat antigen (SERA) 0.0026 0.0074 0.0524
Echinococcus multilocularis pyruvate kinase 0.0027 0.0085 0.0085
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0043 0.0199 0.0836
Entamoeba histolytica calpain large subunit domain III containing protein 0.0149 0.0949 0.2204
Echinococcus multilocularis pyruvate kinase 0.0018 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0144
Schistosoma mansoni hypothetical protein 0.0064 0.0346 0.0346
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0854 0.5936 0.5936
Toxoplasma gondii troponin c, isotype gamma, putative 0.0029 0.0097 0.0513
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0108 0.0571
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0026 0.0074 0.0124
Leishmania major calmodulin, putative 0.0029 0.0097 0.0513
Echinococcus granulosus cathepsin L cysteine protease 0.0026 0.0074 0.0074
Brugia malayi Kringle domain containing protein 0.0017 0.0015 0.0025
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.042 0.1234
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0064 0.0346 0.1835
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0059 0.0312 0.1652
Echinococcus granulosus cathepsin L 0.0026 0.0074 0.0074
Trypanosoma brucei centrin, putative 0.0029 0.0097 0.0513
Trichomonas vaginalis centrin, putative 0.0025 0.0068 0.0162
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0113 0.069 0.2024
Entamoeba histolytica calcium binding family protein 0.0029 0.0097 0.0144
Onchocerca volvulus Myosin regulatory light chain 2 homolog 0.0025 0.0068 0.0284
Onchocerca volvulus 0.0026 0.0074 0.0308
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.0012 0.0036
Entamoeba histolytica cysteine proteinase 1, putative 0.0026 0.0074 0.0088
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0037 0.0089
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Schistosoma mansoni ap endonuclease 0.0038 0.0163 0.0163
Echinococcus multilocularis cyclin dependent kinase 9 0.0156 0.0995 0.0995
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0026 0.0074 0.1624
Leishmania major calcineurin B subunit, putative 0.0029 0.0097 0.0513
Loa Loa (eye worm) hypothetical protein 0.0032 0.0116 0.0195
Entamoeba histolytica hypothetical protein, conserved 0.0029 0.0097 0.0144
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.028 0.028
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0066
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0112 0.0684 0.2006
Leishmania major ATP-dependent phosphofructokinase 0.0113 0.069 0.3655
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Brugia malayi calpain D 0.0064 0.0346 0.0583
Echinococcus granulosus pyruvate kinase 0.0018 0.0017 0.0017
Brugia malayi Protein kinase domain containing protein 0.0028 0.0092 0.0155
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0217 0.0217
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0064 0.0346 0.0583
Trypanosoma brucei calmodulin, putative 0.0029 0.0097 0.0513
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0112 0.0684 0.2006
Mycobacterium ulcerans hypothetical protein 0.0075 0.042 0.0858
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0217 0.0217
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0094 0.0226
Onchocerca volvulus Cathepsin F homolog 0.0026 0.0074 0.0308
Trypanosoma brucei Calpain-like protein CALP1.3 0.0064 0.0346 0.1835
Trypanosoma cruzi calmodulin, putative 0.0029 0.0097 0.0163
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trichomonas vaginalis protein kinase atmrk1, putative 0.0028 0.0092 0.022
Loa Loa (eye worm) calmodulin-like protein 0.0029 0.0097 0.0163
Entamoeba histolytica calcium-binding protein, putative 0.0029 0.0097 0.0144
Loa Loa (eye worm) haspin protein kinase 0.0027 0.0084 0.0142
Loa Loa (eye worm) haspin protein kinase 0.0028 0.0092 0.0155
Schistosoma mansoni calmodulin-related 0.0025 0.0068 0.0068
Onchocerca volvulus 0.0026 0.0074 0.0308
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Trichomonas vaginalis DNA helicase recq1, putative 0.002 0.0037 0.0089
Echinococcus granulosus centrin 2 0.0029 0.0097 0.0097
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0217 0.0217
Giardia lamblia Cathepsin B precursor 0.0026 0.0074 0.0176
Toxoplasma gondii thioredoxin reductase 0.0049 0.0239 0.1267
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0097 0.0232
Onchocerca volvulus 0.0029 0.0097 0.0406
Echinococcus granulosus Pfam-B_8186 domain containing protein 0.0027 0.0084 0.0084
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0217 0.0217
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.1403 0.2363
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0475 0.0799
Entamoeba histolytica hypothetical protein 0.0027 0.0084 0.0114
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0025 0.0068 0.0284
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0037 0.0819
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0017 0.0012 0.0025
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.069 0.1578
Brugia malayi EF hand family protein 0.0029 0.0097 0.0163
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0068 0.0375 0.0375
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0258
Echinococcus granulosus expressed protein 0.0035 0.0136 0.0136
Giardia lamblia Cathepsin L precursor 0.0026 0.0074 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0177 0.1145 0.3361
Brugia malayi RasGEF domain containing protein 0.0025 0.0068 0.0114
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.0595 0.4101 0.4101
Giardia lamblia Cathepsin B precursor 0.0282 0.1887 0.4521
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0012 0.0066
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0213 0.1403 0.2363
Leishmania major programmed cell death 6 protein-like protein 0.0029 0.0097 0.0513
Echinococcus multilocularis hypothetical protein 0.0213 0.1403 0.1403
Mycobacterium tuberculosis Conserved protein 0.0075 0.042 0.1234
Giardia lamblia Cathepsin B precursor 0.0026 0.0074 0.0176
Toxoplasma gondii EF hand domain-containing protein 0.0025 0.0068 0.0359
Echinococcus multilocularis lamin dm0 0.0028 0.0089 0.0089
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0216 0.1419 0.2391
Plasmodium falciparum calpain 0.0064 0.0346 0.7652
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.028 0.028
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0163 0.0163
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.042 0.1008
Giardia lamblia Pyruvate kinase 0.0018 0.0017 0.0042
Plasmodium falciparum cysteine proteinase falcipain 3 0.0026 0.0074 0.1624
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Echinococcus multilocularis tissue type plasminogen activator 0.0017 0.0015 0.0015
Plasmodium vivax unspecified product 0.0026 0.0074 0.0524
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0074 0.0074
Loa Loa (eye worm) calpain D 0.0064 0.0346 0.0583
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0029 0.0097 0.0097
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Leishmania major hypothetical protein, conserved 0.0017 0.0015 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.042 0.0858
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0012 0.0021
Loa Loa (eye worm) myosin Light Chain family member 0.0025 0.0068 0.0114
Trypanosoma cruzi calmodulin, putative 0.0029 0.0097 0.0163
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0208 0.1102
Schistosoma mansoni rotamase 0.0035 0.0136 0.0136
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.042 0.042
Echinococcus granulosus dna polymerase kappa 0.0082 0.0475 0.0475
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0208 0.1102
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Mycobacterium ulcerans 6-phosphofructokinase 0.0113 0.069 0.1408
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Onchocerca volvulus 0.0032 0.0116 0.0486
Brugia malayi EF hand family protein 0.0029 0.0097 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni myosin regulatory light chain 0.0025 0.0068 0.0068
Trypanosoma brucei unspecified product 0.0038 0.016 0.0847
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Brugia malayi beta-lactamase family protein 0.0075 0.042 0.0708
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0026 0.0074 0.0124
Trypanosoma brucei kinesin, putative 0.0149 0.0949 0.5028
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0296 0.1983 0.5732
Trypanosoma brucei unspecified product 0.0038 0.016 0.0847
Echinococcus multilocularis hypothetical protein 0.0027 0.0084 0.0084
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.069 0.1653
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0064 0.0346 0.083
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0136 0.023
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0013 0.0067
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.042 0.1008
Mycobacterium leprae conserved hypothetical protein 0.0075 0.042 0.1123
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0064 0.0346 0.0583
Loa Loa (eye worm) hypothetical protein 0.0081 0.0466 0.0786
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.1403 0.2363
Loa Loa (eye worm) CMGC/CDK/CRK7 protein kinase 0.0028 0.0092 0.0155
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.1403 0.2363
Echinococcus multilocularis 6 phosphofructokinase 0.0113 0.069 0.069
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0082 0.0475 0.1137
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.0131 0.0226
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0178 0.0426
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0108 0.0767
Trypanosoma cruzi centrin, putative 0.0054 0.0272 0.0459
Entamoeba histolytica calmodulin, putative 0.0025 0.0068 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0074 0.0176
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0026 0.0074 0.0088
Echinococcus multilocularis pyruvate kinase 0.0018 0.0017 0.0017
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0029 0.0097 0.0232
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0026 0.0074 0.1624
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0163 0.0275
Trypanosoma brucei pyruvate kinase 1, putative 0.0034 0.0136 0.0721
Giardia lamblia DINP protein human, muc B family 0.0062 0.0328 0.0787
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0177 0.1145 0.3261
Brugia malayi cathepsin F-like cysteine proteinase 0.0026 0.0074 0.0124
Echinococcus multilocularis pyruvate kinase 0.0018 0.0017 0.0017
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0497 0.3408 1
Trypanosoma cruzi calmodulin, putative 0.0029 0.0097 0.0163
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0453 0.3226
Brugia malayi 6-phosphofructokinase 0.0113 0.069 0.1162
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.0012 0.0274
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Giardia lamblia Programmed cell death protein-like protein 0.0025 0.0068 0.0162
Plasmodium falciparum glutathione reductase 0.0049 0.0239 0.5283
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.042 0.0708
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0166 0.1068 0.218
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Mycobacterium leprae Probable lipase LipE 0.0075 0.042 0.1123
Loa Loa (eye worm) hypothetical protein 0.0075 0.042 0.0708
Echinococcus granulosus cyclin dependent kinase 9 0.0156 0.0995 0.0995
Brugia malayi Pyruvate kinase, muscle isozyme 0.0034 0.0136 0.0229
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.0131 0.0692
Schistosoma mansoni calpain (C02 family) 0.0213 0.1403 0.1403
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0026 0.0074 0.0176
Entamoeba histolytica calmodulin, putative 0.0029 0.0097 0.0144
Leishmania major calpain family cysteine protease-like protein 0.0064 0.0346 0.1835
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.004 0.0178 0.0299
Schistosoma mansoni myosin regulatory light chain 0.0025 0.0068 0.0068
Plasmodium falciparum serine repeat antigen 2 0.0026 0.0074 0.1624
Trichomonas vaginalis calcium binding protein, putative 0.0029 0.0097 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0092 0.022
Loa Loa (eye worm) hypothetical protein 0.0566 0.3896 0.6564
Trypanosoma brucei calpain-like protein, putative 0.0213 0.1403 0.7435
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0346 0.0583
Trichomonas vaginalis rotamase, putative 0.0034 0.0131 0.0313
Giardia lamblia Cathepsin B precursor 0.0026 0.0074 0.0176
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0012 0.0021
Schistosoma mansoni serine/threonine protein kinase 0.0156 0.0995 0.0995
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0026 0.0074 0.0524
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0208 0.1102
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.003 0.0104 0.0176
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0012 0.0066
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0163 0.0391
Echinococcus granulosus serine:threonine protein kinase haspin 0.0027 0.0084 0.0084
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0197
Loa Loa (eye worm) hypothetical protein 0.0079 0.0453 0.0762
Entamoeba histolytica calpain family cysteine protease, putative 0.0064 0.0346 0.0748
Leishmania major hypothetical protein, unknown function 0.0064 0.0346 0.1835
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni calmodulin 0.0029 0.0097 0.0097
Trypanosoma brucei trypanothione reductase 0.0049 0.0239 0.1267
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0402 0.0962
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0497 0.3408 0.9932
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.042 0.1234
Trypanosoma brucei Calpain-like protein 2 0.0064 0.0346 0.1835
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0068 0.0162
Echinococcus multilocularis dna polymerase kappa 0.0082 0.0475 0.0475
Echinococcus granulosus Solute carrier family 22 5 0.1073 0.7486 0.7486
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0595 0.4101 0.4101
Loa Loa (eye worm) hypothetical protein 0.0417 0.284 0.4784
Giardia lamblia Cathepsin L precursor 0.0026 0.0074 0.0176
Plasmodium falciparum serine repeat antigen 6 0.0026 0.0074 0.1624
Trichomonas vaginalis G protein-coupled receptor kinase, putative 0.0028 0.0092 0.022
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0097 0.069
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0013 0.0067
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0352 0.238 0.4858
Echinococcus granulosus cathepsin b 0.0854 0.5936 0.5936
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0066
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0217 0.0366
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0163 0.0391
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.028 0.028
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Echinococcus granulosus calcyphosin protein 0.0025 0.0068 0.0068
Loa Loa (eye worm) ctsf protein 0.0026 0.0074 0.0124
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0163 0.0391
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0028 0.0092 0.0155
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0163 0.0305
Leishmania major trypanothione reductase 0.0049 0.0239 0.1267
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0012
Toxoplasma gondii centrin family protein 0.0025 0.0068 0.0359
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0037 0.0037
Loa Loa (eye worm) haspin protein kinase 0.0027 0.0084 0.0142
Giardia lamblia Pyruvate kinase 0.0034 0.0136 0.0326
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0068 0.0375 0.0375
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0854 0.5936 0.5936
Giardia lamblia Hypothetical protein 0.0026 0.0074 0.0176
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0013 0.0067
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.0108 0.0171
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0258
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.042 0.2229
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0108 0.0571
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0074 0.0124
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Schistosoma mansoni neuronal calcium sensor 0.0029 0.0097 0.0097
Brugia malayi intermediate filament protein 0.0028 0.0089 0.0151
Schistosoma mansoni reticulocalbin 0.0029 0.0097 0.0097
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0089 0.0151
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0026 0.0074 0.0524
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0074 0.0308
Trypanosoma brucei calpain, putative 0.0064 0.0346 0.1835
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Echinococcus multilocularis neuropeptide receptor A26 0.048 0.329 0.329
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Schistosoma mansoni hypothetical protein 0.0027 0.0084 0.0084
Brugia malayi Pyruvate kinase, M2 isozyme 0.0034 0.0136 0.0229
Brugia malayi calpain 7 0.0213 0.1403 0.2363
Onchocerca volvulus 0.0026 0.0074 0.0308
Schistosoma mansoni intermediate filament proteins 0.0028 0.0089 0.0089
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0113 0.069 0.1119
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0026 0.0074 0.1624
Echinococcus multilocularis calpain family protein 1, d 0.0417 0.284 0.284
Toxoplasma gondii pyruvate kinase PyK1 0.0034 0.0136 0.0721
Leishmania major i/6 autoantigen-like protein 0.0029 0.0097 0.0513
Giardia lamblia Cysteine protease 0.0026 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0028 0.0089 0.0151
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Brugia malayi Bloom's syndrome protein homolog 0.002 0.0037 0.0062
Plasmodium falciparum MO15-related protein kinase 0.0028 0.0092 0.2027
Echinococcus multilocularis pyruvate kinase 0.0034 0.0136 0.0136
Echinococcus granulosus pyruvate kinase 0.0034 0.0136 0.0136
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0108 0.0571
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0375 0.0631
Echinococcus granulosus EF HAND 1 calcium binding site 0.0029 0.0097 0.0097
Echinococcus multilocularis chromobox protein 1 0.0072 0.0402 0.0402
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0012 0.0021
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0026 0.0074 0.0524
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0111 0.0111
Echinococcus granulosus calmodulin 0.0029 0.0097 0.0097
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0124 0.0772 0.2159
Schistosoma mansoni neuronal calcium sensor 0.0029 0.0097 0.0097
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0136 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0328 0.0964
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0075 0.042 0.0708
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Brugia malayi Cell division protein kinase 2 0.0028 0.0092 0.0155
Onchocerca volvulus 0.0026 0.0074 0.0308
Loa Loa (eye worm) hypothetical protein 0.0044 0.0207 0.0349
Plasmodium falciparum cysteine repeat modular protein 1 0.0017 0.0015 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Plasmodium falciparum serine repeat antigen 4 0.0026 0.0074 0.1624
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.042 0.1234
Plasmodium vivax centrin-1, putative 0.0029 0.0097 0.069
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0013 0.0279
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0083 0.0594
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0346 0.0583
Entamoeba histolytica grainin 2 0.0025 0.0068 0.0074
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0131 0.022
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0059 0.0312 0.0914
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0113 0.069 0.1917
Schistosoma mansoni DNA polymerase eta 0.0081 0.0466 0.0466
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0012 0.0066
Schistosoma mansoni ap endonuclease 0.0038 0.0163 0.0163
Schistosoma mansoni DNA helicase recq1 0.002 0.0037 0.0037
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0168 0.1083 0.3179
Schistosoma mansoni DNA helicase recq5 0.002 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.002 0.0037 0.0062
Giardia lamblia Cysteine protease 0.0026 0.0074 0.0176
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0017 0.0092
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Schistosoma mansoni myosin light chain 0.0025 0.0068 0.0068
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.042 0.1234
Plasmodium falciparum pyruvate kinase 0.0034 0.0136 0.3007
Giardia lamblia Hypothetical protein 0.0026 0.0074 0.0176
Brugia malayi Cathepsin L-like cysteine proteinase 0.0026 0.0074 0.0124
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0207 0.1097
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0217 0.0217
Toxoplasma gondii calmodulin CAM1 0.0029 0.0097 0.0513
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Trypanosoma brucei hypothetical protein 0.0064 0.0346 0.1835
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0312 0.0636
Trichomonas vaginalis hypothetical protein 0.0064 0.0346 0.083
Echinococcus granulosus pyruvate kinase 0.0034 0.0136 0.0136
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Loa Loa (eye worm) phosphofructokinase 0.0113 0.069 0.1162
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.0172 0.0172
Echinococcus granulosus calpain 0.0213 0.1403 0.1403
Plasmodium vivax vivapain-2 0.0026 0.0074 0.0524
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Schistosoma mansoni centrin-related 0.0029 0.0097 0.0097
Leishmania major calmodulin-like protein 0.0029 0.0097 0.0513
Trypanosoma cruzi cysteine protease, putative 0.0026 0.0074 0.0124
Trichomonas vaginalis serine/threonine kinase, putative 0.0028 0.0092 0.022
Loa Loa (eye worm) RecQ helicase 0.002 0.0037 0.0062
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.0012 0.0274
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Leishmania major hypothetical protein, conserved 0.0064 0.0346 0.1835
Leishmania major DNA polymerase kappa, putative 0.0062 0.0328 0.1741
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0199 0.0478
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0854 0.5936 1
Echinococcus multilocularis Myosin regulatory light chain 0.0025 0.0068 0.0068
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Loa Loa (eye worm) hypothetical protein 0.0075 0.042 0.0708
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0136 0.057
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0163 0.0275
Trichomonas vaginalis calcium binding protein, putative 0.0025 0.0068 0.0162
Echinococcus multilocularis calbindin 32 0.0029 0.0097 0.0097
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Plasmodium vivax SET domain protein, putative 0.0031 0.0111 0.0793
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Echinococcus granulosus serine:threonine protein kinase haspin 0.0027 0.0084 0.0084
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0026 0.0074 0.0524
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0136 0.0229
Entamoeba histolytica protein kinase, putative 0.015 0.0956 0.2222
Echinococcus granulosus transcription factor Dp 1 0.0039 0.0172 0.0172
Leishmania major phospholipase c-like protein 0.0029 0.0097 0.0513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Brugia malayi phosphofructokinase 0.0113 0.069 0.1162
Giardia lamblia Cathepsin L precursor 0.0026 0.0074 0.0176
Mycobacterium leprae Probable pyruvate kinase PykA 0.0034 0.0136 0.0285
Trichomonas vaginalis calpain, putative 0.0064 0.0346 0.083
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0097 0.0232
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0111 0.0111
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.069 0.1653
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0034 0.0136 0.0399
Onchocerca volvulus 0.0075 0.042 0.1762
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Schistosoma mansoni calpain-2 (C02 family) 0.0064 0.0346 0.0346
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0282 0.1887 0.1887
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0026 0.0074 0.0124
Toxoplasma gondii cathepsin B 0.0282 0.1887 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0021
Plasmodium falciparum serine repeat antigen 7 0.0026 0.0074 0.1624
Giardia lamblia Fructose-bisphosphate aldolase 0.0605 0.4173 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0062
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0475 0.0799
Trypanosoma brucei calpain, putative 0.0064 0.0346 0.1835
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.004 0.0116
Loa Loa (eye worm) beta-lactamase 0.0075 0.042 0.0708
Echinococcus multilocularis calpain 7 (C02 family) 0.0213 0.1403 0.1403
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0026 0.0074 0.0524
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Echinococcus multilocularis EF hand domain containing family member A2 0.0029 0.0097 0.0097
Leishmania major DNA polymerase eta, putative 0.0043 0.0199 0.1054
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0013 0.0021
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Giardia lamblia Encystation-specific protease 0.0026 0.0074 0.0176
Plasmodium falciparum serine repeat antigen 8 0.0026 0.0074 0.1624
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0013 0.0067
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.042 0.0708
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.003 0.0104 0.0553
Trypanosoma brucei protein kinase, putative 0.0028 0.0092 0.0486
Giardia lamblia Cathepsin L-like protease 0.0026 0.0074 0.0176
Echinococcus granulosus calcium uptake protein 1 0.0029 0.0097 0.0097
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Echinococcus multilocularis geminin 0.0175 0.1131 0.1131
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0026 0.0074 0.0176
Trichomonas vaginalis phosphofructokinase, putative 0.0113 0.069 0.1653
Trichomonas vaginalis set domain proteins, putative 0.0246 0.163 0.3906
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Giardia lamblia Kinase, CAMK CAMKL 0.0028 0.0092 0.022
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.042 0.0858
Schistosoma mansoni rab 0.0029 0.0097 0.0097
Schistosoma mansoni calpain-7 (C02 family) 0.0213 0.1403 0.1403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0163 0.0249
Entamoeba histolytica phosphofructokinase, putative 0.0113 0.069 0.1578
Echinococcus granulosus tissue type plasminogen activator 0.0017 0.0015 0.0015
Echinococcus multilocularis programmed cell death protein 6 0.0025 0.0068 0.0068
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0112 0.0684 0.2006
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0066
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0111 0.0111
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0083 0.0441
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0037 0.0819
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0021
Giardia lamblia Cathepsin B precursor 0.0026 0.0074 0.0176
Onchocerca volvulus 0.0029 0.0097 0.0406
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0124 0.0772 0.2265
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0213 0.1403 0.2363
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0213 0.1403 0.7435
Onchocerca volvulus Cathepsin L homolog 0.0026 0.0074 0.0308
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0854 0.5936 0.5936
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0163 0.0866
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Leishmania major calmodulin-like protein 0.0029 0.0097 0.0513
Trypanosoma cruzi major cysteine proteinase, putative 0.0026 0.0074 0.0124
Brugia malayi beta-lactamase family protein 0.0075 0.042 0.0708
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0068 0.0375 0.0375
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0089 0.0151
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0068 0.0375 0.0631
Echinococcus multilocularis cyclin dependent kinase 9 0.0183 0.1187 0.1187
Echinococcus multilocularis EF hand domain containing family member A2 0.0029 0.0097 0.0097
Trypanosoma brucei hypothetical protein, conserved 0.0029 0.0097 0.0513
Brugia malayi calpain family protein 1 0.0566 0.3896 0.6564
Schistosoma mansoni calpain-7 (C02 family) 0.0213 0.1403 0.1403
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0059 0.0312 0.0636
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0012 0.0066
Giardia lamblia Cathepsin B precursor 0.0282 0.1887 0.4521
Plasmodium falciparum glutathione reductase 0.0017 0.0012 0.0274
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0475 0.2515
Giardia lamblia Cathepsin L precursor 0.0026 0.0074 0.0176
Trypanosoma brucei protein I/6 0.0029 0.0097 0.0513
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0012 0.0025
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0258
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0026 0.0074 0.0524
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.05 0.3431 0.7003
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0012
Trypanosoma brucei unspecified product 0.0075 0.0426 0.226
Mycobacterium ulcerans hypothetical protein 0.0021 0.004 0.0081
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0402 0.0962
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Plasmodium falciparum flap endonuclease 1 0.0027 0.0083 0.184
Echinococcus multilocularis lamin 0.0028 0.0089 0.0089
Giardia lamblia Cysteine protease 0.0026 0.0074 0.0176
Brugia malayi calpain 5 0.0149 0.0949 0.1598
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0059 0.0312 0.0312
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0059 0.0312 0.0525
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.0079 0.0453 0.1218
Onchocerca volvulus 0.0017 0.0015 0.0061
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0083 0.0083
Trypanosoma cruzi cruzipain precursor, putative 0.0026 0.0074 0.0124
Schistosoma mansoni cathepsin S (C01 family) 0.0026 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0013 0.0013
Echinococcus granulosus cathepsin L 0.0026 0.0074 0.0074
Entamoeba histolytica protein kinase domain containing protein 0.0028 0.0092 0.0132
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0854 0.5936 0.5936
Chlamydia trachomatis endonuclease IV 0.0079 0.0453 0.0898
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0083 0.0441
Entamoeba histolytica grainin, putative 0.0029 0.0097 0.0144
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Onchocerca volvulus Pyruvate kinase homolog 0.0034 0.0136 0.057
Trichomonas vaginalis calcineurin B subunit, putative 0.0029 0.0097 0.0232
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0258
Echinococcus granulosus cathepsin l1 0.0026 0.0074 0.0074
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0029 0.0097 0.0163
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0475 0.0969
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.0079 0.0453 0.1328
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0083 0.0199
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0059 0.0312 0.0312
Leishmania major centrin, putative 0.0029 0.0097 0.0513
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0083 0.014
Echinococcus multilocularis cysteine protease 0.0026 0.0074 0.0074
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0064 0.0346 0.083
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0346 0.0583
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0402 0.0676
Echinococcus granulosus Cell division cycle 2 protein kinase 0.0028 0.0092 0.0092
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0061 0.0322
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Echinococcus granulosus calpain 7 C02 family 0.0213 0.1403 0.1403
Schistosoma mansoni hypothetical protein 0.0175 0.1131 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0074 0.0176
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.0131 0.022
Toxoplasma gondii endonuclease IV APN 0.0079 0.0453 0.2399
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0136 0.0229
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.0595 0.4101 0.4101
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.05 0.3431 1
Trypanosoma cruzi conserved protein 0.0064 0.0346 0.0583
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.028 0.028
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0328 0.1741
Schistosoma mansoni pyruvate kinase 0.0018 0.0017 0.0017
Leishmania major serine/threonine kinase-like protein, putative 0.0028 0.0092 0.0486
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0012 0.0021
Onchocerca volvulus 0.0028 0.0089 0.0374
Brugia malayi Pre-SET motif family protein 0.0031 0.0111 0.0187
Echinococcus granulosus flap endonuclease 1 0.0027 0.0083 0.0083
Plasmodium vivax vivapain-3 0.0026 0.0074 0.0524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0012 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0013 0.0021
Schistosoma mansoni chromobox protein 0.0072 0.0402 0.0402
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0282 0.1887 0.3178
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0217 0.0217
Loa Loa (eye worm) hypothetical protein 0.0064 0.0346 0.0583
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0497 0.3408 0.6956
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0083 0.0199
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Trichomonas vaginalis calcium binding protein, putative 0.0029 0.0097 0.0232
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0217 0.0366
Loa Loa (eye worm) EF hand family protein 0.0029 0.0097 0.0163
Trypanosoma brucei Calpain-like protein 1.1 0.0064 0.0346 0.1835
Mycobacterium ulcerans endonuclease IV 0.0079 0.0453 0.0924
Trichomonas vaginalis calpain, putative 0.0064 0.0346 0.083
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0112 0.0684 0.2006
Echinococcus multilocularis Calcium binding protein 0.0025 0.0068 0.0068
Chlamydia trachomatis transglycolase/transpeptidase 0.0709 0.4911 1
Echinococcus granulosus calpain A 0.0213 0.1403 0.1403
Mycobacterium ulcerans beta-lactamase 0.0075 0.042 0.0858
Echinococcus multilocularis cathepsin b 0.0854 0.5936 0.5936
Giardia lamblia Kinase, CAMK CAMKL 0.0028 0.0092 0.022
Trichomonas vaginalis conserved hypothetical protein 0.05 0.3431 0.8221
Toxoplasma gondii calcium binding protein precursor, putative 0.0025 0.0068 0.0359
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0108 0.0194
Plasmodium vivax calpain, putative 0.0213 0.1403 1
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0068 0.0375 0.0816
Onchocerca volvulus 0.0026 0.0074 0.0308
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0346 0.0583
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0064 0.0346 0.1835
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0282 0.1887 0.4521
Entamoeba histolytica calmodulin, putative 0.0029 0.0097 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Onchocerca volvulus 0.0075 0.042 0.1762
Trichomonas vaginalis caltractin, putative 0.0025 0.0068 0.0162
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0074 0.0176
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0124 0.0772 0.2265
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0163 0.0275
Treponema pallidum penicillin-binding protein (pbp-2) 0.05 0.3431 0.5646
Trypanosoma cruzi cysteine proteinase, putative 0.0026 0.0074 0.0124
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0114
Mycobacterium ulcerans lipase LipD 0.0075 0.042 0.0858
Echinococcus granulosus cathepsin l cysteine peptidase 0.0026 0.0074 0.0074
Schistosoma mansoni lamin 0.0028 0.0089 0.0089
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.0079 0.0453 0.0762
Mycobacterium tuberculosis Conserved protein 0.0075 0.042 0.1234
Brugia malayi Calmodulin-like protein 0.0029 0.0097 0.0163
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0083 0.0112
Trichomonas vaginalis chromobox protein, putative 0.0043 0.0199 0.0478
Brugia malayi cyclin-dependent kinase 9 0.0156 0.0995 0.1676
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0064 0.0346 0.0583
Echinococcus granulosus mitogen activated protein kinase 15 0.0028 0.0092 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0049 0.0239 0.0702
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0017 0.0384
Echinococcus multilocularis pyruvate kinase 0.0034 0.0136 0.0136
Brugia malayi polk-prov protein 0.0044 0.0207 0.0349
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0089 0.0151
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0028 0.0092 0.0155
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0017 0.0124
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0074 0.0074
Echinococcus granulosus chromobox protein 1 0.0072 0.0402 0.0402
Echinococcus multilocularis serine:threonine protein kinase NLK 0.0028 0.0092 0.0092
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0066
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0163 0.0479
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0013 0.0067
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0708 0.4899 1
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Trypanosoma cruzi caltractin, putative 0.0029 0.0097 0.0163
Trichomonas vaginalis centrin, putative 0.0025 0.0068 0.0162
Toxoplasma gondii cathepsin CPL 0.0026 0.0074 0.039
Trichomonas vaginalis esterase, putative 0.0075 0.042 0.1008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis centrin, putative 0.0025 0.0068 0.0162
Leishmania major DNA polymerase eta, putative 0.0081 0.0466 0.2472
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0012 0.0012
Toxoplasma gondii centrin, putative 0.0029 0.0097 0.0513
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0062
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Trypanosoma brucei DNA polymerase eta, putative 0.0081 0.0466 0.2472
Schistosoma mansoni reticulocalbin 0.0029 0.0097 0.0097
Entamoeba histolytica cysteine proteinase 2 0.0026 0.0074 0.0088
Schistosoma mansoni calpain C (C02 family) 0.0213 0.1403 0.1403
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Leishmania major calpain protease-like protein 0.0064 0.0346 0.1835
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0064 0.0346 0.0583
Loa Loa (eye worm) hypothetical protein 0.0075 0.042 0.0708
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0108 0.0258
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Brugia malayi cyclin-dependent kinase 7 homolog 0.0028 0.0092 0.0155
Schistosoma mansoni centrin 0.0029 0.0097 0.0097
Brugia malayi hypothetical protein 0.0027 0.0084 0.0142
Brugia malayi calpain family protein 1 0.0566 0.3896 0.6564
Giardia lamblia Cathepsin L-like protease 0.0026 0.0074 0.0176
Brugia malayi GSG2 0.0027 0.0084 0.0142
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0163 0.0163
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.069 0.069
Echinococcus granulosus 6 phosphofructokinase 0.0113 0.069 0.069
Entamoeba histolytica cell division protein kinase 2, putative 0.0028 0.0092 0.0132
Plasmodium vivax serine-repeat antigen (SERA) 0.0026 0.0074 0.0524
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0605 0.4173 1
Leishmania major hypothetical protein, conserved 0.0029 0.0097 0.0513
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Trypanosoma cruzi I/6 autoantigen, putative 0.0029 0.0097 0.0163
Echinococcus multilocularis calpain 0.0213 0.1403 0.1403
Plasmodium falciparum thioredoxin reductase 0.0049 0.0239 0.5283
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Loa Loa (eye worm) fibroinase 0.0026 0.0074 0.0124
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0037 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.042 0.042
Plasmodium vivax unspecified product 0.0026 0.0074 0.0524
Echinococcus granulosus cysteine protease 0.0026 0.0074 0.0074
Trypanosoma cruzi DNA polymerase eta, putative 0.0081 0.0466 0.0786
Echinococcus granulosus cathepsin l1 0.0026 0.0074 0.0074
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0074 0.0074
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0055 0.0283 0.0477
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.028 0.0822
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0064 0.0346 0.083
Echinococcus multilocularis bloom syndrome protein 0.002 0.0037 0.0037
Trypanosoma brucei centrin-3 0.0054 0.0272 0.1443
Echinococcus granulosus EF hand domain containing family member A2 0.0029 0.0097 0.0097
Onchocerca volvulus 0.0026 0.0074 0.0308
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.2363
Schistosoma mansoni protein kinase 0.0028 0.0092 0.0092
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0026 0.0074 0.0524
Schistosoma mansoni hypothetical protein 0.0175 0.1131 0.1131
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Brugia malayi cathepsin L precursor 0.0026 0.0074 0.0124
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0083 0.0441
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0074 0.0074
Trypanosoma brucei Mitogen-activated protein kinase 10, putative 0.0028 0.0092 0.0486
Schistosoma mansoni hypothetical protein 0.0029 0.0097 0.0097
Trichomonas vaginalis DNA helicase recq, putative 0.002 0.0037 0.0089
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0113 0.069 0.3655
Onchocerca volvulus 0.0043 0.0195 0.0815
Onchocerca volvulus 0.0075 0.042 0.1762
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0029 0.0097 0.0144
Echinococcus granulosus programmed cell death protein 0.0054 0.0272 0.0272
Echinococcus multilocularis neuropeptide s receptor 0.048 0.329 0.329
Loa Loa (eye worm) programmed cell death protein 6 0.0029 0.0097 0.0163
Loa Loa (eye worm) hypothetical protein 0.0025 0.0068 0.0114
Onchocerca volvulus 0.0029 0.0097 0.0406
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.0595 0.4101 0.4101
Echinococcus granulosus geminin 0.0175 0.1131 0.1131
Trypanosoma brucei Calpain-like protein 1.2 0.0064 0.0346 0.1835
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0136 0.023
Plasmodium falciparum cysteine proteinase falcipain 1 0.0026 0.0074 0.1624
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.042 0.0708
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0068 0.0375 0.0631
Schistosoma mansoni serine/threonine kinase 0.0028 0.0092 0.0092
Echinococcus multilocularis programmed cell death protein 0.0054 0.0272 0.0272
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0026 0.0074 0.0074
Echinococcus multilocularis cathepsin L 0.0026 0.0074 0.0074
Echinococcus granulosus neuropeptide receptor A26 0.048 0.329 0.329
Giardia lamblia Sgs1 DNA helicase, putative 0.002 0.0037 0.0089
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0074 0.0124
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0017 0.0015 0.0104
Trypanosoma brucei Component of motile flagella 41 0.0029 0.0097 0.0513
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Chlamydia trachomatis pyruvate kinase 0.0034 0.0136 0.0252
Brugia malayi Neuronal calcium sensor family protein 1 0.0025 0.0068 0.0114
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.1835
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0026 0.0074 0.0124
Leishmania major hypothetical protein, conserved 0.0029 0.0097 0.0513
Echinococcus multilocularis thioredoxin glutathione reductase 0.0049 0.0239 0.0239
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Brugia malayi chromobox protein homolog 3 0.004 0.0178 0.0299
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.042 0.1008
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Trichomonas vaginalis calcium binding protein, putative 0.0054 0.0272 0.0652
Schistosoma mansoni 6-phosphofructokinase 0.0113 0.069 0.069
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0163 0.1164
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0026 0.0074 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Echinococcus granulosus serine:threonine protein kinase haspin 0.0027 0.0084 0.0084
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.003 0.0104 0.0744
Trypanosoma cruzi trypanothione reductase, putative 0.0049 0.0239 0.0403
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0074 0.0124
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0026 0.0074 0.0524
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0136 0.0327
Trypanosoma cruzi pyruvate kinase 2, putative 0.0034 0.0136 0.0229
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0026 0.0074 0.0074
Trichomonas vaginalis AGC family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0026 0.0074 0.0176
Toxoplasma gondii calmodulin, putative 0.0025 0.0068 0.0359
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.042 0.042
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0605 0.4173 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0043 0.0195 0.0195
Echinococcus multilocularis neurocalcin 0.0029 0.0097 0.0097
Schistosoma mansoni mitochondrial solute carrier 0.0029 0.0097 0.0097
Toxoplasma gondii calmodulin CAM2 0.0025 0.0068 0.0359
Trichomonas vaginalis centrin, putative 0.0029 0.0097 0.0232
Trichomonas vaginalis CMGC family protein kinase 0.0028 0.0092 0.022
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0026 0.0074 0.0176
Loa Loa (eye worm) hypothetical protein 0.0026 0.0074 0.0124
Trichomonas vaginalis centrin, putative 0.0029 0.0097 0.0232
Echinococcus multilocularis calcium uptake protein 1 0.0029 0.0097 0.0097
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.028 0.0472
Entamoeba histolytica cysteine proteinase, putative 0.0026 0.0074 0.0088
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0029 0.0097 0.0163
Leishmania major cathepsin L-like protease 0.0026 0.0074 0.039
Mycobacterium tuberculosis Probable reductase 0.0112 0.0684 0.2006
Schistosoma mansoni hypothetical protein 0.0017 0.0015 0.0015
Trypanosoma brucei DNA polymerase IV, putative 0.0082 0.0475 0.2515
Plasmodium vivax glutathione reductase, putative 0.0049 0.0239 0.1705
Treponema pallidum fructose-bisphosphate aldolase 0.0605 0.4173 0.6872
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0328 0.1741
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0074 0.0074
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0166 0.1068 0.3033
Toxoplasma gondii calcium-dependent protein kinase 0.003 0.0104 0.0553
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Trypanosoma cruzi centrin, putative 0.0054 0.0272 0.0459
Echinococcus granulosus programmed cell death protein 6 0.0025 0.0068 0.0068
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0026 0.0074 0.0074
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0012 0.0088
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.0079 0.0453 1
Plasmodium falciparum centrin-1 0.0029 0.0097 0.214
Brugia malayi calcium-binding protein 0.0029 0.0097 0.0163
Echinococcus granulosus neurocalcin 0.0029 0.0097 0.0097
Brugia malayi cathepsin L-like precursor 0.0026 0.0074 0.0124
Schistosoma mansoni Mername-AA248 (C02 family) 0.0213 0.1403 0.1403
Loa Loa (eye worm) pyruvate kinase 0.0034 0.0136 0.0229
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Toxoplasma gondii EFHC1, putative 0.0029 0.0097 0.0513
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Trichomonas vaginalis calmodulin, putative 0.0029 0.0097 0.0232
Echinococcus granulosus lamin dm0 0.0028 0.0089 0.0089
Brugia malayi calpain 5 0.0064 0.0346 0.0583
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0026 0.0074 0.0176
Echinococcus granulosus bloom syndrome protein 0.002 0.0037 0.0037
Toxoplasma gondii centrin 0.0029 0.0097 0.0513
Mycobacterium ulcerans epimerase 0.0021 0.004 0.0081
Mycobacterium ulcerans pyruvate kinase 0.0034 0.0136 0.0278
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0026 0.0074 0.039
Echinococcus multilocularis Cell division cycle 2 protein kinase 0.0028 0.0092 0.0092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0068 0.0375 0.1987
Brugia malayi Cathepsin L-like precursor 0.0026 0.0074 0.0124
Brugia malayi fibroinase precursor 0.0026 0.0074 0.0124
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0029 0.0097 0.0144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0082 0.0475 0.0799
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.042 0.1234
Echinococcus multilocularis serine:threonine protein kinase haspin 0.0027 0.0084 0.0084
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0094 0.0226
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.0108 0.0767
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0064 0.0346 0.1835
Onchocerca volvulus 0.0026 0.0074 0.0308
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.2363
Trichomonas vaginalis rotamase, putative 0.0035 0.0136 0.0327
Trichomonas vaginalis pyruvate kinase, putative 0.0034 0.0136 0.0326
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0108 0.0258
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0026 0.0074 0.0176
Trypanosoma brucei I/6 autoantigen 0.0029 0.0097 0.0513
Trypanosoma cruzi cysteine peptidase, putative 0.0026 0.0074 0.0124
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.7435
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.042 0.1234
Echinococcus multilocularis calpain A 0.0595 0.4101 0.4101
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Toxoplasma gondii kringle domain-containing protein 0.0017 0.0015 0.0077
Echinococcus multilocularis cathepsin L 0.0026 0.0074 0.0074
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0029 0.0097 0.0097
Echinococcus granulosus chromobox protein 1 0.0072 0.0402 0.0402
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Mycobacterium tuberculosis Probable oxidoreductase 0.0124 0.0772 0.2265
Plasmodium vivax pyruvate kinase, putative 0.0034 0.0136 0.097
Loa Loa (eye worm) hypothetical protein 0.0034 0.0136 0.0229
Trichomonas vaginalis CAMK family protein kinase 0.0028 0.0092 0.022
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.004 0.0081
Brugia malayi Flap endonuclease-1 0.0027 0.0083 0.014
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0064 0.0346 0.0583
Brugia malayi cathepsin Z-like cysteine proteinase 0.0026 0.0074 0.0124
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.2363
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.004 0.0067
Mycobacterium ulcerans DNA polymerase IV 0.0082 0.0475 0.0969
Trypanosoma cruzi Mitogen-activated protein kinase 10, putative 0.0028 0.0092 0.0155
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.002 0.0037 0.0197
Loa Loa (eye worm) TK/ROR protein kinase 0.0017 0.0015 0.0025
Toxoplasma gondii exonuclease III APE 0.0038 0.0163 0.0866
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0064 0.0346 0.0583
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0012 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0296 0.1983 0.4049
Trypanosoma brucei DNA polymerase kappa, putative 0.0082 0.0475 0.2515
Trichomonas vaginalis DNA polymerase eta, putative 0.0082 0.0475 0.1137
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0013 0.0021
Leishmania major DNA damage repair protein, putative 0.0017 0.0013 0.0067
Schistosoma mansoni neuronal calcium sensor 0.0029 0.0097 0.0097
Echinococcus multilocularis calumenin 0.0029 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0026 0.0074 0.0176
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0026 0.0074 0.0124
Echinococcus multilocularis neuronal calcium sensor 0.0029 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0097 0.0163
Toxoplasma gondii hypothetical protein 0.0064 0.0346 0.1835
Entamoeba histolytica cysteine protease, putative 0.0026 0.0074 0.0088
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0213 0.1403 0.2363
Plasmodium vivax thioredoxin reductase, putative 0.0049 0.0239 0.1705
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.003 0.0104 0.0176
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0068 0.0375 0.1987
Loa Loa (eye worm) 6-phosphofructokinase 0.0113 0.069 0.1162
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0029 0.0097 0.0097
Loa Loa (eye worm) calpain 0.0213 0.1403 0.2363
Echinococcus multilocularis cathepsin L cysteine protease 0.0026 0.0074 0.0074
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0455 0.3108 0.9049
Echinococcus multilocularis calmodulin 0.0029 0.0097 0.0097
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0015 0.0025
Brugia malayi Papain family cysteine protease containing protein 0.0026 0.0074 0.0124
Entamoeba histolytica protein kinase domain containing protein 0.0156 0.0995 0.2316
Schistosoma mansoni calmodulin related calcium binding protein 0.0029 0.0097 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0026 0.0074 0.0176
Echinococcus granulosus intermediate filament protein 0.0028 0.0089 0.0089
Mycobacterium ulcerans hypothetical protein 0.0017 0.0013 0.0026
Giardia lamblia Cathepsin L precursor 0.0026 0.0074 0.0176
Treponema pallidum hypothetical protein 0.0165 0.1061 0.1731
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0028 0.0092 0.0155
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0013 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0044 0.0207 0.1097
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0111 0.0111
Echinococcus multilocularis calmodulin 0.0029 0.0097 0.0097
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0029 0.0097 0.0097

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 9 nM Inhibitory activity of the compound against Staphylococcus aureus MRS ChEMBL. 12657260
MIC (functional) = 0.125 ug ml-1 Antibacterial activity of the compound against E. faecalis 1 ChEMBL. 12657260
MIC (functional) = 1 ug ml-1 Antibacterial activity of the compound against S. aureus Oxford ChEMBL. 12657260

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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