Detailed information for compound 330470

Basic information

Technical information
  • TDR Targets ID: 330470
  • Name: ethyl (E,4S)-6-methyl-4-[[(2S)-4-methyl-2-[[( 2S)-4-methyl-2-(phenylmethoxycarbonylamino)pe ntanoyl]amino]pentanoyl]amino]hept-2-enoate
  • MW: 545.711 | Formula: C30H47N3O6
  • H donors: 3 H acceptors: 4 LogP: 5.81 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 2
  • SMILES: CCOC(=O)/C=C/[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)OCc1ccccc1)CC(C)C)CC(C)C)CC(C)C
  • InChi: 1S/C30H47N3O6/c1-8-38-27(34)15-14-24(16-20(2)3)31-28(35)25(17-21(4)5)32-29(36)26(18-22(6)7)33-30(37)39-19-23-12-10-9-11-13-23/h9-15,20-22,24-26H,8,16-19H2,1-7H3,(H,31,35)(H,32,36)(H,33,37)/b15-14+/t24-,25+,26+/m1/s1
  • InChiKey: APNSQIQECQEJJX-DJYRPUISSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ethyl (E,4S)-4-[[(2S)-2-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-6-methyl-hept-2-enoate
  • (E,4S)-4-[[(2S)-2-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-1-oxopentyl]amino]-4-methyl-1-oxopentyl]amino]-6-methyl-2-heptenoic acid ethyl ester
  • (E,4S)-4-[[(2S)-2-[[(2S)-2-(benzyloxycarbonylamino)-4-methyl-pentanoyl]amino]-4-methyl-pentanoyl]amino]-6-methyl-hept-2-enoic acid ethyl ester
  • (E,4S)-6-methyl-4-[[(2S)-4-methyl-2-[[(2S)-4-methyl-1-oxo-2-[[oxo-(phenylmethoxy)methyl]amino]pentyl]amino]-1-oxopentyl]amino]hept-2-enoic acid ethyl ester

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0128 0.0866 0.4151
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0344
Echinococcus granulosus multidrug resistance associated protein 7 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Brugia malayi hypothetical protein 0.0041 0.0234 0.0422
Onchocerca volvulus 0.0293 0.2065 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0502 0.0502
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.034 0.0509
Echinococcus multilocularis tyrosine protein kinase Blk 0.0034 0.0182 0.0182
Schistosoma mansoni survival motor neuron protein 0.0047 0.0277 0.0277
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0293 0.2065 0.3729
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0038 0.0212 0.0769
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0091
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0202 0.0364
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0175 0.1205 0.1205
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0024 0.0109 0.0456
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0014 0.0038 0.0282
Loa Loa (eye worm) cytochrome P450 family protein 0.0056 0.034 0.0509
Leishmania major ATP-binding cassette protein subfamily C, member 5, putative 0.0014 0.0035 0.0112
Loa Loa (eye worm) hypothetical protein 0.0018 0.0067 0.0085
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0115 0.0774 0.2884
Loa Loa (eye worm) hypothetical protein 0.0033 0.0171 0.0247
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0277 0.0501
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0052 0.0052
Echinococcus granulosus fmrfamide receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0297 0.1095
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0052 0.0052
Brugia malayi GnHR receptor homolog 0.0016 0.0052 0.0094
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Loa Loa (eye worm) hypothetical protein 0.0033 0.0176 0.0254
Brugia malayi nuclear receptor NHR-88 0.0078 0.0502 0.0907
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0034 0.0182 0.0182
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0241 0.0436
Leishmania major DNA repair protein, putative 0.0018 0.0067 0.0226
Schistosoma mansoni hypothetical protein 0.004 0.0224 0.0224
Brugia malayi nuclear hormone receptor 0.0037 0.0202 0.0364
Echinococcus granulosus allatostatin A receptor 0.0016 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0072 0.0681
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.0502 0.0502
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0234 0.0234
Brugia malayi multidrug resistance related protein 1 0.0014 0.0035 0.0064
Trypanosoma brucei poly(adp-ribose) polymerase 0.0115 0.0774 0.336
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0202 0.0294
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.009
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0201 0.1396 0.1396
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Brugia malayi Serotonin receptor 0.0016 0.0052 0.0094
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Brugia malayi Serotonin receptor 0.0016 0.0052 0.0094
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0015 0.0046 0.5
Brugia malayi Cytochrome P450 family protein 0.0056 0.034 0.0614
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0014 0.0038 0.0038
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0234 0.0422
Toxoplasma gondii hypothetical protein 0.0019 0.0072 0.0295
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0502 0.0907
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0038 0.0208 0.0208
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0038 0.0149
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0368 0.1589
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0042 0.0241 0.0887
Loa Loa (eye worm) acetylcholine receptor protein 0.014 0.095 0.1458
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0297 0.1095
Onchocerca volvulus 0.0045 0.0258 0.1186
Loa Loa (eye worm) hypothetical protein 0.0099 0.0655 0.1
Brugia malayi Cytochrome P450 family protein 0.0038 0.0212 0.0383
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0014 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0106 0.1082
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0769 0.5536 1
Echinococcus granulosus neuropeptide receptor 0.0016 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Brugia malayi Tnks protein 0.0276 0.1944 0.3511
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0075 0.0479 0.0479
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0075 0.0479 0.1779
Echinococcus granulosus WGR domain containing protein 0.0044 0.0252 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0014 0.0038 0.009
Brugia malayi CHE-14 protein 0.0041 0.0234 0.0424
Echinococcus granulosus hypothetical protein 0.0016 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Onchocerca volvulus 0.0037 0.0202 0.0912
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0019 0.0072 0.0092
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0171 0.1864
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0202 0.0202
Echinococcus multilocularis chromobox protein 2 0.0011 0.0015 0.0015
Entamoeba histolytica hypothetical protein 0.0049 0.0287 0.2298
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Echinococcus granulosus single minded 2 0.0044 0.0254 0.0254
Trypanosoma brucei cAMP-specific phosphodiesterase 0.006 0.0368 0.1589
Schistosoma mansoni hypothetical protein 0.0166 0.1141 0.1141
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0004 0.0004
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0276 0.3112
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0019 0.0072 0.0295
Echinococcus granulosus cAMP and cAMP inhibited cGMP 3'5' cyclic 0.0026 0.0125 0.0125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0276 0.3112
Onchocerca volvulus 0.0065 0.0403 0.1896
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0293 0.2065 0.2065
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0052 0.0052
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0014 0.0038 0.0749
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0038 0.0208 0.0208
Brugia malayi excitatory GABA receptor EXP-1A 0.0293 0.2065 0.3729
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0293 0.2065 0.3194
Plasmodium vivax JmjC domain containing protein 0.0016 0.005 0.0122
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0091
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0293 0.2065 0.2065
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0014 0.0038 0.0127
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0208 0.0208
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0635 0.5122
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0293 0.2065 0.3729
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.0127
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0202 0.0202
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0293 0.2065 0.3729
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0003
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0208 0.0208
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0014 0.0038 0.0282
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0233 0.2595
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0106 0.1082
Brugia malayi hypothetical protein 0.0024 0.0106 0.0191
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0038 0.0212 0.0906
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0092 0.0092
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.0502 0.0907
Schistosoma mansoni chromobox protein 0.0011 0.0015 0.0015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Echinococcus granulosus dual 3'5' cyclic AMP and GMP phosphodiesterase 0.006 0.0368 0.0368
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0004 0.0004
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0035 0.0253
Brugia malayi hypothetical protein 0.014 0.095 0.1715
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0075 0.0479 0.0479
Loa Loa (eye worm) hypothetical protein 0.0028 0.0136 0.0192
Echinococcus multilocularis protein patched 0.0041 0.0234 0.0234
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0202 0.0912
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.004
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0502 0.0502
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0014 0.0038 0.0282
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0293 0.2065 0.3729
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0372 0.056
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0046 0.0156
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.0502 0.0907
Echinococcus multilocularis dual 3',5' cyclic AMP and GMP phosphodiesterase 0.006 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0128 0.0866 0.1328
Echinococcus multilocularis nAChR subunit 0.0293 0.2065 0.2065
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0234 0.0234
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0038 0.004
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0293 0.2065 0.2065
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0015 0.0046 0.0373
Schistosoma mansoni hypothetical protein 0.004 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.063 0.452 0.7017
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0035 0.0136
Leishmania major phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.0123
Echinococcus granulosus nAChR subunit 0.0293 0.2065 0.2065
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0233 0.2595
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Onchocerca volvulus DNA ligase 3 homolog 0.0018 0.0067 0.0256
Echinococcus granulosus geminin 0.0166 0.1141 0.1141
Echinococcus granulosus SAM domain containing protein 0.0024 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.003 0.0152 0.0216
Loa Loa (eye worm) hypothetical protein 0.0067 0.042 0.0634
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0127 0.0855 1
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.005 0.005
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0072 0.0295
Brugia malayi nuclear receptor NHR-88 0.0037 0.0202 0.0364
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0936 0.0936
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.005 0.0059
Plasmodium falciparum tyrosine kinase-like protein 0.0026 0.0119 0.0502
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0046 0.0046
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0038 0.0149
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0014 0.0038 0.0127
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0202 0.0202
Echinococcus multilocularis carbonic anhydrase 0.0109 0.0726 0.0726
Plasmodium falciparum protein kinase, putative 0.0026 0.0119 0.0502
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0014 0.0038 0.0038
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0052 0.0052
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0092 0.0092
Brugia malayi Heterochromatin protein 1 0.0068 0.043 0.0777
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Onchocerca volvulus 0.0016 0.0052 0.0182
Brugia malayi Zinc finger, C2H2 type family protein 0.0127 0.0855 0.1545
Plasmodium falciparum dihydroorotate dehydrogenase 0.0324 0.2295 1
Brugia malayi Protein kinase domain containing protein 0.0015 0.0039 0.0071
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0024 0.0106 0.0106
Echinococcus granulosus multidrug resistance associated protein 1 0.0014 0.0035 0.0035
Schistosoma mansoni lip-related protein (liprin) alpha 0.0024 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0038 0.0212 0.0749
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Onchocerca volvulus 0.0016 0.0052 0.0182
Onchocerca volvulus 0.014 0.095 0.4561
Entamoeba histolytica hypothetical protein 0.0014 0.0038 0.0276
Brugia malayi MAP kinase sur-1 0.005 0.0297 0.0536
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.014 0.095 0.095
Brugia malayi hypothetical protein 0.0231 0.1619 0.2924
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0014 0.0038 0.0282
Onchocerca volvulus 0.0014 0.0038 0.0116
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0293 0.2065 0.3729
Echinococcus granulosus carbonic anhydrase II 0.0201 0.1396 0.1396
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.0324 0.2295 1
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0368 0.1363
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0075 0.0479 0.1779
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0201 0.1396 0.5215
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0345
Echinococcus granulosus epidermal growth factor receptor 0.0081 0.0521 0.0521
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0293 0.2065 0.2065
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0038 0.0212 0.0769
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0368 0.4205
Brugia malayi Dopamine receptor 0.0016 0.0052 0.0094
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0276
Brugia malayi Cation transporter family protein 0.0293 0.2065 0.3729
Echinococcus granulosus glycine receptor subunit beta 0.0293 0.2065 0.2065
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0324 0.2295 0.8582
Schistosoma mansoni neurotransmitter gated ion channel 0.014 0.095 0.095
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0024 0.0106 0.0106
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0052 0.0094
Schistosoma mansoni carbonic anhydrase 0.0109 0.0726 0.0726
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis chromobox protein 1 0.0068 0.043 0.043
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0202 0.0294
Onchocerca volvulus 0.0293 0.2065 1
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0047 0.0276 0.1187
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0293 0.2065 0.2065
Echinococcus granulosus glycine receptor subunit alpha 1 0.0293 0.2065 0.2065
Echinococcus multilocularis carbonic anhydrase 0.0109 0.0726 0.0726
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0109 0.0726 0.111
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0052 0.0052
Brugia malayi WGR domain containing protein 0.0115 0.0774 0.1398
Schistosoma mansoni biogenic amine receptor 0.0016 0.0052 0.0052
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0293 0.2065 0.2065
Schistosoma mansoni hypothetical protein 0.004 0.0224 0.0224
Leishmania major p-glycoprotein e 0.0014 0.0035 0.0112
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0293 0.2065 0.2065
Giardia lamblia ABC transporter, putative 0.0014 0.0035 0.0687
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0038 0.0069
Brugia malayi Neurabin protein 1 0.0024 0.0106 0.0191
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0024 0.0106 0.0145
Schistosoma mansoni camp/cgmp cyclic nucleotide phosphodiesterase 0.006 0.0368 0.0368
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0038 0.0282
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0038 0.0212 0.0778
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0075 0.0479 0.0479
Brugia malayi nuclear hormone receptor 0.0078 0.0502 0.0907
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0052 0.0052
Brugia malayi tailless protein 0.0037 0.0202 0.0364
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0075 0.0479 0.2073
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0663 0.0663
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0014 0.0038 0.0149
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0016 0.005 0.0058
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Entamoeba histolytica hypothetical protein 0.0011 0.0015 0.0084
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0052 0.0061
Echinococcus granulosus Ankyrin 0.0018 0.0066 0.0066
Brugia malayi ecdysone receptor 0.0037 0.0202 0.0364
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0038 0.0069
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0042 0.0241 0.1923
Schistosoma mansoni jumonji domain containing protein 0.006 0.0372 0.0372
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Echinococcus multilocularis epidermal growth factor receptor 0.0081 0.0521 0.0521
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0075 0.0479 0.1712
Brugia malayi Cytochrome P450 family protein 0.0094 0.062 0.112
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trypanosoma brucei protein kinase, putative 0.005 0.0297 0.1276
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0153 0.1048 0.1894
Schistosoma mansoni chromobox protein 0.0068 0.043 0.043
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0052 0.0052
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Entamoeba histolytica hypothetical protein 0.0022 0.0092 0.0716
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.0502 0.0502
Echinococcus multilocularis expressed conserved protein 0.009 0.0592 0.0592
Trypanosoma cruzi multidrug resistance protein E, putative 0.0014 0.0035 0.0117
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0014 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0212 0.2344
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0502 0.0502
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.014 0.095 0.1458
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Echinococcus multilocularis tyrosine protein kinase HCK 0.003 0.0155 0.0155
Leishmania major hypothetical protein, conserved 0.0391 0.2778 1
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0202 0.0202
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis poly (ADP ribose) polymerase 0.007 0.0446 0.0446
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0115 0.0774 0.2884
Entamoeba histolytica multidrug resistance protein, putative 0.0014 0.0035 0.0253
Echinococcus multilocularis stromal interaction molecule 1 0.0024 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Leishmania major hypothetical protein, conserved 0.0016 0.005 0.0166
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0297 0.0297
Leishmania major cytochrome p450-like protein 0.0038 0.0212 0.0749
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0297 0.3352
Brugia malayi ecdysteroid receptor 0.0078 0.0502 0.0907
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0202 0.0202
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0046 0.0373
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0293 0.2065 0.3729
Brugia malayi G-protein coupled receptor 0.0016 0.0052 0.0094
Echinococcus multilocularis survival motor neuron protein 1 0.0231 0.1619 0.1619
Brugia malayi larval opioid receptor 0.0016 0.0052 0.0094
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0038 0.0212 0.0906
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0033 0.0171 0.0171
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.005 0.005
Trypanosoma brucei p-glycoprotein 0.0014 0.0035 0.0136
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0038 0.0149
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0052 0.0052
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0052 0.0052
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.0502 0.0907
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus granulosus lysine specific demethylase 5A 0.006 0.0372 0.0372
Leishmania major protein kinase, putative 0.0016 0.0049 0.0162
Leishmania major phosphatidylinositol 3-kinase, putative 0.0075 0.0479 0.1712
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0082 0.0532 0.0532
Trypanosoma brucei DNA repair protein, putative 0.0018 0.0067 0.0274
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0038 0.004
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0046 0.0083
Brugia malayi Immunoglobulin I-set domain containing protein 0.0014 0.0036 0.0065
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0109 0.0726 0.1311
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0075 0.0479 0.3856
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0003
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.005 0.0201
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0075 0.0479 0.2073
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0038 0.0212 0.0769
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.0149
Onchocerca volvulus Tankyrase homolog 0.025 0.1757 0.8498
Brugia malayi protein-tyrosine kinase 0.0034 0.0182 0.0328
Brugia malayi PAS domain containing protein 0.0059 0.0367 0.0662
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0052 0.0052
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0052 0.0052
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.0502 0.0502
Brugia malayi M-phase phosphoprotein, mpp8 0.0011 0.0015 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Entamoeba histolytica hypothetical protein 0.0049 0.0287 0.2298
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0014 0.0037 0.0037
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0038 0.0212 0.0906
Echinococcus granulosus glycine receptor subunit beta 0.0293 0.2065 0.2065
Mycobacterium ulcerans putative regulatory protein 0.0044 0.0254 0.109
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Onchocerca volvulus 0.0293 0.2065 1
Echinococcus multilocularis lysine specific demethylase 5A 0.006 0.0372 0.0372
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0015 0.0084
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0176 0.0318
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0019 0.0072 0.0149
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0038 0.0212 0.0769
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0014 0.0038 0.0282
Loa Loa (eye worm) hypothetical protein 0.0113 0.0757 0.1158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0051
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0014 0.0038 0.0149
Echinococcus granulosus g protein coupled receptor 0.0016 0.0052 0.0052
Schistosoma mansoni carbonic anhydrase-related 0.0109 0.0726 0.0726
Schistosoma mansoni patched 1 0.0041 0.0234 0.0234
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Brugia malayi FAT domain containing protein 0.0033 0.0171 0.0309
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Schistosoma mansoni protein phosphatase 2C 0.0016 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0109 0.0726 0.0726
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.005 0.0201
Echinococcus multilocularis 0.0046 0.0268 0.0268
Echinococcus multilocularis phd:f box containing protein 0.0016 0.005 0.005
Trichomonas vaginalis c2h2 zinc finger protein, putative 0.0024 0.0106 0.1082
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0034 0.0653
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0233 0.1064
Echinococcus multilocularis Ankyrin 0.0018 0.0066 0.0066
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0153 0.1048 0.1894
Brugia malayi Pax transcription factor protein 2 0.0235 0.1649 0.2978
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.0502 0.0907
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Echinococcus granulosus netrin receptor unc 5 0.0014 0.0036 0.0036
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0293 0.2065 0.3729
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.0127
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0014 0.0036 0.0036
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0061 0.0075
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0109 0.0726 0.1311
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0014 0.0038 0.0127
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0035 0.019 0.0343
Onchocerca volvulus 0.0016 0.0052 0.0182
Brugia malayi nuclear receptor RXR 0.0037 0.0202 0.0364
Toxoplasma gondii Alpha-galactosidase 0.0014 0.0037 0.0141
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0052 0.0052
Toxoplasma gondii hypothetical protein 0.0109 0.0726 0.3149
Schistosoma mansoni amine GPCR 0.0016 0.0052 0.0052
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0153 0.1048 0.1894
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0033 0.0171 0.0171
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.1506
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0289 0.0429
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0014 0.0038 0.0038
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0109 0.0726 0.1311
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0202 0.0364
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0052 0.0052
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0067 0.042 0.042
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0234 0.0344
Loa Loa (eye worm) DR-78 0.0037 0.0202 0.0294
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0075 0.0479 0.0479
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0038 0.0208 0.0208
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0052 0.0052
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0014 0.0038 0.0038
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0038 0.0212 0.0906
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0075 0.0479 0.2073
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0293 0.2065 0.3194
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Schistosoma mansoni multidrug resistance protein 0.0014 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0106 0.1082
Schistosoma mansoni cytochrome P450 0.0038 0.0212 0.0212
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.0502 0.0502
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0123 0.0831 0.0831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Loa Loa (eye worm) hypothetical protein 0.0096 0.0635 0.0969
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0153 0.1048 0.1894
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0038 0.0212 0.0906
Onchocerca volvulus 0.0016 0.0052 0.0182
Plasmodium vivax heterochromatin protein 1, putative 0.0011 0.0015 0.0027
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0046 0.0373
Loa Loa (eye worm) SRC-1 0.0038 0.0208 0.0304
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0052 0.0052
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0067 0.042 0.4823
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0315 0.3569
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0344
Schistosoma mansoni tankyrase 0.0278 0.1959 0.1959
Brugia malayi Protein kinase domain containing protein 0.0048 0.0286 0.0517
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.0127 0.0855 1
Onchocerca volvulus 0.0293 0.2065 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0052 0.0052
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.0015 0.0045
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0201 0.1396 0.5215
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0052 0.0052
Echinococcus multilocularis serine protein kinase ATM 0.0042 0.0241 0.0241
Schistosoma mansoni tyrosine kinase 0.0079 0.0508 0.0508
Schistosoma mansoni hypothetical protein 0.0011 0.0015 0.0015
Onchocerca volvulus 0.0016 0.0052 0.0182
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Echinococcus granulosus jun protein 0.0082 0.0532 0.0532
Plasmodium vivax hypothetical protein 0.0014 0.0038 0.009
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0202 0.0202
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0286 0.0426
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0019 0.0072 0.0149
Schistosoma mansoni tyrosine kinase 0.0149 0.1021 0.1021
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.005 0.0201
Brugia malayi jmjC domain containing protein 0.006 0.0372 0.0672
Echinococcus multilocularis GPCR, family 2 0.0015 0.0046 0.0046
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0094 0.0615 0.0938
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Brugia malayi Dopamine receptor protein 2 0.0016 0.0052 0.0094
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0293 0.2065 0.2065
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0052 0.0061
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0293 0.2065 0.2065
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Onchocerca volvulus 0.0153 0.1048 0.5043
Echinococcus granulosus expressed conserved protein 0.009 0.0592 0.0592
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0293 0.2065 0.2065
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0035 0.0117
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0038 0.0212 0.0906
Echinococcus multilocularis tumor protein p63 0.0677 0.4862 0.4862
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0052 0.0061
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Leishmania major ABC-thiol transporter 0.0014 0.0035 0.0112
Brugia malayi ORL1-like opioid receptor 0.0016 0.0052 0.0094
Schistosoma mansoni nAChR subunit 0.014 0.095 0.095
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0293 0.2065 0.3729
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.019 0.019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Echinococcus multilocularis nAChR subunit 0.0153 0.1048 0.1048
Echinococcus granulosus death domain containing protein 0.0014 0.0036 0.0036
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0038 0.0212 0.0906
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.0324 0.2295 1
Echinococcus multilocularis multidrug resistance associated protein 4 0.0011 0.0011 0.0011
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Brugia malayi WGR domain containing protein 0.0179 0.1236 0.2232
Brugia malayi neuropeptide F receptor 0.0016 0.0052 0.0094
Echinococcus multilocularis jun protein 0.0082 0.0532 0.0532
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.013 0.1377
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0368 0.1363
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0293 0.2065 0.2065
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0202 0.0202
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0048 0.0286 0.0286
Brugia malayi SRC-1 0.0038 0.0208 0.0375
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0038 0.0212 0.0769
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0038 0.0212 0.0769
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0003
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0202 0.0202
Echinococcus granulosus FTZ F1 alpha 0.0078 0.0502 0.0502
Echinococcus multilocularis transfer RNA-Lys 0.0044 0.0254 0.0254
Onchocerca volvulus 0.0024 0.0106 0.0444
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.0015 0.0026
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0091
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0297 0.0297
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0038 0.0212 0.0769
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0052 0.0052
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.008 0.0515 0.0783
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0038 0.0208 0.0208
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Schistosoma mansoni biogenic amine receptor 0.0016 0.0052 0.0052
Trichomonas vaginalis rod cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Brugia malayi Furin-like cysteine rich region family protein 0.0149 0.1021 0.1845
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0042 0.0241 0.0356
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0015 0.0015
Trypanosoma brucei cytochrome P450, putative 0.0056 0.034 0.1464
Schistosoma mansoni cgmp-dependent 35-cyclic phosphodiesterase 0.0026 0.0125 0.0125
Loa Loa (eye worm) phosphatidylinositol kinase 0.0014 0.0038 0.004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0113 0.0753 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0052 0.0094
Onchocerca volvulus 0.0016 0.0052 0.0182
Echinococcus granulosus aryl hydrocarbon receptor 0.0128 0.0869 0.0869
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0293 0.2065 0.2065
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0276
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0014 0.0038 0.0038
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.0324 0.2295 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0038 0.004
Echinococcus multilocularis Chromobox protein 3 0.0011 0.0015 0.0015
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0046 0.0373
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0293 0.2065 0.3729
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0038 0.0208 0.0208
Schistosoma mansoni multidrug resistance protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0052 0.0094
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0014 0.0038 0.004
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.006 0.0368 0.4205
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0212 0.0961
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0052 0.0052
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0179 0.1236 1
Schistosoma mansoni neuropeptide receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0038 0.0212 0.0906
Loa Loa (eye worm) TK/EGFR protein kinase 0.0149 0.1021 0.157
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Echinococcus granulosus poly ADP ribose polymerase 1 0.0179 0.1236 0.1236
Echinococcus granulosus sex peptide receptor 0.0016 0.0052 0.0052
Entamoeba histolytica ABC transporter, putative 0.0014 0.0035 0.0253
Entamoeba histolytica hypothetical protein 0.0014 0.0038 0.0276
Onchocerca volvulus 0.0016 0.0052 0.0182
Leishmania major carbonic anhydrase-like protein 0.0201 0.1396 0.5018
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0014 0.0038 0.0069
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0793 0.5713 0.5713
Trichomonas vaginalis cAMP-specific phosphodiesterase, putative 0.0041 0.023 0.2558
Echinococcus multilocularis Chromo domain 0.0011 0.0015 0.0015
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0075 0.0479 0.3856
Mycobacterium leprae putative cytochrome p450 0.0038 0.0212 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus granulosus poly (ADP ribose) polymerase 0.0044 0.0252 0.0252
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0052 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.013 0.1377
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.0234 0.0234
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0015 0.0046 0.0046
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0014 0.0038 0.0282
Brugia malayi Liprin-alpha 2 0.0024 0.0106 0.0191
Loa Loa (eye worm) cytochrome P450 family protein 0.0094 0.062 0.0945
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.019 0.019
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0052 0.0182
Schistosoma mansoni neuropeptide receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0014 0.0036 0.0036
Brugia malayi Cytochrome P450 family protein 0.0056 0.034 0.0614
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0014 0.0035 0.0253
Echinococcus granulosus Protein patched homolog 1 0.0041 0.0234 0.0234
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0034 0.0182 0.0182
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0015 0.0046 0.0373
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0038 0.0212 0.0769
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0663 0.0663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.0502 0.0762
Echinococcus granulosus glycine receptor subunit alpha 1 0.0293 0.2065 0.2065
Entamoeba histolytica hypothetical protein 0.0042 0.0241 0.1923
Leishmania major phosphatidylinositol kinase, putative 0.0014 0.0038 0.0123
Loa Loa (eye worm) TK protein kinase 0.0034 0.0182 0.0263
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0046 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0046 0.0373
Schistosoma mansoni phd/f-box containing protein 0.0016 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.0234 0.0234
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Loa Loa (eye worm) hypothetical protein 0.0231 0.1619 0.25
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0038 0.0212 0.0906
Trichomonas vaginalis cGMP-inhibited 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Loa Loa (eye worm) carbonic anhydrase 3 0.0201 0.1396 0.2154
Entamoeba histolytica hypothetical protein 0.0153 0.1048 0.848
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0042 0.0241 0.0436
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.005 0.005
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.005 0.0059
Echinococcus multilocularis microtubule associated protein 2 0.1382 1 1
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0035 0.0687
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0014 0.0038 0.0127
Entamoeba histolytica hypothetical protein 0.0049 0.0287 0.2298
Brugia malayi neuropeptide F receptor 0.0016 0.0052 0.0094
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0127 0.0855 0.0855
Plasmodium falciparum heterochromatin protein 1 0.0011 0.0015 0.0045
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0016 0.0053 0.0053
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0663 0.0663
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0052 0.0094
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0046 0.0046
Entamoeba histolytica hypothetical protein 0.0011 0.0015 0.0084
Brugia malayi Death domain containing protein 0.0014 0.0036 0.0065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0936 0.0936
Schistosoma mansoni cellular tumor antigen P53 0.0099 0.0655 0.0655
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0635 0.1147
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Plasmodium vivax tyrosine kinase-like protein, putative 0.0026 0.0119 0.0304
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0038 0.0212 0.0778
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0038 0.0208 0.0208
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.0502 0.0907
Trichomonas vaginalis chromobox protein, putative 0.0068 0.043 0.4939
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0032 0.0168 0.0168
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0234 0.0234
Echinococcus multilocularis carbonic anhydrase II 0.0201 0.1396 0.1396
Schistosoma mansoni tyrosine kinase 0.0048 0.0286 0.0286
Brugia malayi hypothetical protein 0.014 0.095 0.1715
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.014 0.095 0.1715
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0052 0.0052
Onchocerca volvulus 0.0153 0.1048 0.5043
Echinococcus granulosus neuropeptide receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis 0.0038 0.0212 0.0212
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0127
Entamoeba histolytica zinc finger protein, putative 0.0049 0.0287 0.2298
Brugia malayi ABC transporter transmembrane region family protein 0.0014 0.0035 0.0064
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0212 0.2344
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0368 0.4205
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Brugia malayi G protein-coupled receptor 0.0016 0.0052 0.0094
Onchocerca volvulus 0.0016 0.0052 0.0182
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0289 0.0521
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.1506
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0052 0.0052
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0042 0.0241 0.1034
Onchocerca volvulus 0.0011 0.0015 0.00000011989
Onchocerca volvulus Netrin receptor homolog 0.0014 0.0036 0.0103
Echinococcus granulosus stromal interaction molecule 1 0.0024 0.0106 0.0106
Echinococcus granulosus tyrosine protein kinase Lyn 0.0038 0.0211 0.0211
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0179 0.1236 0.1236
Onchocerca volvulus 0.0293 0.2065 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0145
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0202 0.0364
Schistosoma mansoni nAChR subunit 0.014 0.095 0.095
Entamoeba histolytica hypothetical protein 0.0014 0.0038 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0024 0.0106 0.1082
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Giardia lamblia GTOR 0.0075 0.0479 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.0502 0.0907
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) ACC-1 protein 0.0293 0.2065 0.3194
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0052 0.0052
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.0502 0.0762
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0208 0.0208
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0297 0.0442
Trypanosoma brucei carbonic anhydrase-like protein 0.0201 0.1396 0.6076
Brugia malayi SET domain containing protein 0.0011 0.0015 0.0026
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Toxoplasma gondii GAF domain-containing protein 0.0019 0.0072 0.0295
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.0324 0.2295 0.8582
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0297 0.6167
Schistosoma mansoni hypothetical protein 0.0047 0.0277 0.0277
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0038 0.0212 0.0769
Schistosoma mansoni single-minded 0.0059 0.0367 0.0367
Schistosoma mansoni microtubule-associated protein tau 0.1382 1 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.0646 0.0646
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.014 0.095 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0038 0.0208 0.0208
Onchocerca volvulus 0.0099 0.0655 0.3123
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.0067 0.0235
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0052 0.0094
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.0324 0.2295 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0011 0.0015 0.0015
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.006 0.0372 0.0372
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0014 0.0036 0.0036
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0014 0.0038 0.0127
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.005 0.0172
Onchocerca volvulus 0.0016 0.0052 0.0182
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.0234 0.0345
Brugia malayi conserved hypotetical protein 0.0037 0.0202 0.0364
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0344
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0052 0.0052
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0014 0.0038 0.0149
Schistosoma mansoni carbonic anhydrase-related 0.0109 0.0726 0.0726
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0075 0.0479 0.1779
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0046 0.0373
Brugia malayi jmjC domain containing protein 0.0016 0.005 0.0091
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0038 0.004
Echinococcus multilocularis aryl hydrocarbon receptor 0.0128 0.0869 0.0869
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.0324 0.2295 0.5
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0015 0.0027
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0052 0.0061
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0038 0.0149
Echinococcus granulosus orexin receptor type 2 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0033 0.0171 0.0171
Echinococcus multilocularis glycine receptor subunit beta 0.0293 0.2065 0.2065
Leishmania major protein kinase, putative 0.0016 0.0049 0.0162
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0289 0.0521
Loa Loa (eye worm) hypothetical protein 0.0049 0.0289 0.0429
Onchocerca volvulus 0.0016 0.0052 0.0182
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0014 0.0038 0.0282
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0635 0.0635
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Loa Loa (eye worm) TK protein kinase 0.003 0.0155 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Schistosoma mansoni hypothetical protein 0.0033 0.0176 0.0176
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Schistosoma mansoni sarm1 0.0024 0.0106 0.0106
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0115 0.0774 0.1185
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0024 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0106
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0052 0.0052
Schistosoma mansoni chromobox protein 0.0068 0.043 0.043
Brugia malayi jmjC domain containing protein 0.006 0.0372 0.0672
Echinococcus multilocularis 0.0014 0.0038 0.0038
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0052 0.0052
Onchocerca volvulus 0.0293 0.2065 1
Trypanosoma brucei multidrug resistance-associated protein, putative 0.0014 0.0035 0.0136
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0324 0.2295 0.4145
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0075 0.0479 0.0865
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0145
Loa Loa (eye worm) hypothetical protein 0.0893 0.6436 1
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0035 0.0253
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Echinococcus multilocularis multidrug resistance associated protein 1 0.0014 0.0035 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0315 0.3569
Loa Loa (eye worm) hypothetical protein 0.0015 0.0046 0.0052
Onchocerca volvulus 0.0235 0.1649 0.797
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0202 0.0202
Plasmodium falciparum GAF domain-related protein, putative 0.0019 0.0072 0.0295
Loa Loa (eye worm) hypothetical protein 0.0109 0.0726 0.111
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Loa Loa (eye worm) hypothetical protein 0.0014 0.0038 0.004
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.014 0.095 0.1715
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.0502 0.2378
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0201 0.1396 0.2154
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0052 0.0052
Brugia malayi CHD4 protein 0.0011 0.0015 0.0026
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0179 0.1236 0.1236
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0127 0.0855 0.0855
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0276
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0052 0.0052
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.0026 0.0125 0.1317
Echinococcus granulosus ATP binding cassette sub family G 0.001 0.0004 0.0004
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0052 0.0061
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.006 0.0368 0.1363
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0123 0.0831 0.0831
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0038 0.0069
Echinococcus granulosus Chromobox protein 3 0.0011 0.0015 0.0015
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0014 0.0038 0.009
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0293 0.2065 0.2065
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0075 0.0479 0.0479
Echinococcus granulosus tyrosine kinase 0.0034 0.0182 0.0182
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.0502 0.0762
Echinococcus multilocularis liprin beta 1 0.0024 0.0106 0.0106
Onchocerca volvulus 0.014 0.095 0.4561
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.009
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0038 0.0212 0.0906
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0052 0.0052
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0038 0.0212 0.0906
Plasmodium vivax hypothetical protein, conserved 0.0019 0.0072 0.0179
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0127 0.0855 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0014 0.0038 0.0149
Schistosoma mansoni amine GPCR 0.0016 0.0052 0.0052
Toxoplasma gondii FATC domain-containing protein 0.0042 0.0241 0.1034
Echinococcus granulosus nuclear factor of activated T cells 5 0.0072 0.0458 0.0458
Trypanosoma cruzi multidrug resistance-associated protein, putative 0.0014 0.0035 0.0117
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.0502 0.0907
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0014 0.0038 0.0127
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.014 0.095 0.095
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.005 0.005
Toxoplasma gondii melibiase subfamily protein 0.01 0.0663 0.2877
Schistosoma mansoni carbonic anhydrase-related 0.0109 0.0726 0.0726
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0016 0.005 0.005
Schistosoma mansoni jumonji domain containing protein 0.0016 0.005 0.005
Echinococcus multilocularis Zinc finger, PHD finger 0.0014 0.0038 0.0038
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0028 0.0136 0.0494
Echinococcus granulosus insulin receptor 0.0048 0.0286 0.0286
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0052 0.0052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0038 0.0069
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0014 0.0038 0.0282
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0038 0.0212 0.0769
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Giardia lamblia Hypothetical protein 0.0014 0.0038 0.0749
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0081 0.0521 0.0521
Echinococcus granulosus somatostatin receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Brugia malayi Melatonin receptor type 1A 0.0016 0.0052 0.0094
Echinococcus granulosus epidermal growth factor receptor 0.0149 0.1021 0.1021
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0014 0.0038 0.0276
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.0276
Schistosoma mansoni chromobox protein 0.0011 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0038 0.0212 0.0769
Echinococcus granulosus nAChR subunit 0.0153 0.1048 0.1048
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0072 0.0458 0.0458
Brugia malayi hypothetical protein 0.014 0.095 0.1715
Echinococcus granulosus chromobox protein 2 0.0011 0.0015 0.0015
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0502 0.0502
Schistosoma mansoni netrin receptor unc5 0.0014 0.0036 0.0036
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.0502 0.0502
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.034 0.1257
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0297 0.3352
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0038 0.0038
Echinococcus granulosus serotonin receptor 0.0016 0.0052 0.0052
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0297 0.1095
Echinococcus granulosus liprin beta 1 0.0024 0.0106 0.0106
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.0502 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0136 0.1445
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.0502 0.0502
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0052 0.0052
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0042 0.0241 0.0241
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0202 0.0364
Schistosoma mansoni opsin-like receptor 0.0016 0.0052 0.0052
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0035 0.0253
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0014 0.0038 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0297 0.0297
Mycobacterium leprae Possible regulatory protein 0.0015 0.0046 0.0034
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0372 0.0372
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.01 0.0663 0.0663
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.014 0.095 0.1715
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Echinococcus granulosus tyrosine protein kinase Src64B 0.0038 0.0208 0.0208
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0052 0.0052
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0052 0.0094
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0052 0.0052
Echinococcus multilocularis liprin alpha 2 0.0024 0.0106 0.0106
Leishmania major pentamidine resistance protein 1 0.0014 0.0035 0.0112
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0208 0.0208
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0014 0.0038 0.0282
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0052 0.0052
Trichomonas vaginalis cAMP/cGMP cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0502 0.0502
Schistosoma mansoni tyrosine kinase 0.0081 0.0521 0.0521
Echinococcus granulosus tankyrase 0.0278 0.1956 0.1956
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Leishmania major cytochrome p450-like protein 0.0038 0.0212 0.0749
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0127 0.0855 0.3189
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0038 0.0212 0.0769
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0109 0.0726 0.1311
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0038 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0052 0.0315 0.3569
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0293 0.2065 0.2065
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0075 0.0479 0.1779
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.1506
Schistosoma mansoni hypothetical protein 0.0035 0.019 0.019
Schistosoma mansoni multidrug resistance protein 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Loa Loa (eye worm) LGC-31 protein 0.0293 0.2065 0.3194
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.1075 0.7767 0.7767
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0052 0.0094
Echinococcus multilocularis Glycoside hydrolase, family 27 0.01 0.0663 0.0663
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.005 0.0201
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0014 0.0038 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Toxoplasma gondii cytochrome p450 superfamily protein 0.0038 0.0212 0.0906
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0127 0.0855 0.0855
Giardia lamblia Multidrug resistance-associated protein 1 0.0014 0.0035 0.0687
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0003
Schistosoma mansoni acetylcholine receptor-related 0.014 0.095 0.095
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0635 0.0635
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0052 0.0094
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0502 0.0907
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0202 0.0202
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0293 0.2065 0.2065
Loa Loa (eye worm) helicase 0.0011 0.0015 0.0003
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0293 0.2065 0.3194
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0293 0.2065 0.2065
Schistosoma mansoni neuropeptide receptor 0.0016 0.0052 0.0052
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0297 0.1276
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0293 0.2065 0.3729
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0208 0.0208
Trichomonas vaginalis cAMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0049 0.0168
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.0502 0.0762
Brugia malayi steroid hormone receptor 0.0078 0.0502 0.0907
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.014 0.095 0.095
Echinococcus granulosus cytochrome P450 2K1 0.0038 0.0212 0.0212
Schistosoma mansoni coup transcription factor 0.0078 0.0502 0.0502
Schistosoma mansoni fkbp-rapamycin associated protein 0.0042 0.0241 0.0241
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.006 0.0372 0.0372
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0038 0.0149
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.0015 0.0015
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0015 0.0084
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0153 0.1048 0.1048
Loa Loa (eye worm) cytochrome P450 0.0038 0.0212 0.031
Entamoeba histolytica protein kinase, putative 0.003 0.0155 0.1222
Schistosoma mansoni retinoic acid receptor RXR 0.0175 0.1205 0.1205
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0052 0.0052
Onchocerca volvulus 0.0016 0.0052 0.0182
Brugia malayi RE15519p 0.0016 0.0052 0.0094
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.0015 0.0026
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0049 0.0168
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0014 0.0038 0.0038
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0324 0.2295 0.6057
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0038 0.0212 0.0769
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0038 0.0212 0.0906
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0145
Onchocerca volvulus 0.0016 0.0052 0.0182
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.0502 0.0762
Brugia malayi G-protein coupled receptor 0.0016 0.0052 0.0094
Echinococcus multilocularis thyroid hormone receptor alpha 0.0201 0.1399 0.1399
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0014 0.0038 0.0127
Echinococcus granulosus g protein coupled receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0052 0.0061
Onchocerca volvulus 0.0024 0.0106 0.0444
Echinococcus granulosus Chromo domain 0.0011 0.0015 0.0015
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0202 0.0202
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.014 0.095 0.1458
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0014 0.0038 0.0276
Schistosoma mansoni multidrug resistance protein 0.0014 0.0035 0.0035
Brugia malayi hypothetical protein 0.0015 0.0046 0.0083
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0046 0.0083
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0046 0.0051
Onchocerca volvulus 0.0016 0.0052 0.0182
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0127 0.0855 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0016 0.0049 0.0168
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0038 0.0212 0.0906
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0293 0.2065 0.2065
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.0502 0.0502
Echinococcus granulosus multidrug resistance associated protein 4 0.0011 0.0011 0.0011
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0038 0.0212 0.0769
Schistosoma mansoni tyrosine kinase 0.0079 0.0508 0.0508
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0052 0.0061
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.01 0.0663 0.0663
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.0502 0.0762
Loa Loa (eye worm) hypothetical protein 0.0014 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Brugia malayi Dopamine receptor protein 1 0.0016 0.0052 0.0094
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.005 0.0059
Brugia malayi hypothetical protein 0.0037 0.0202 0.0364
Plasmodium vivax hypothetical protein, conserved 0.0011 0.0015 0.0027
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0067 0.042 0.042
Echinococcus granulosus tyrosine protein kinase Fyn 0.0038 0.0208 0.0208
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0106
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Leishmania major ATP-binding cassette protein subfamily C, member 1, putative 0.0014 0.0035 0.0112
Echinococcus granulosus survival motor neuron protein 1 0.0231 0.1619 0.1619
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0202 0.1406 0.217
Echinococcus multilocularis insulin receptor 0.0048 0.0286 0.0286
Plasmodium vivax tryptophan-rich antigen (Pv-fam-a) 0.0529 0.3786 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0145
Echinococcus granulosus GPCR family 2 0.0015 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Echinococcus multilocularis sex peptide receptor 0.0016 0.0052 0.0052
Brugia malayi bHLH-PAS transcription factor 0.0044 0.0254 0.0459
Brugia malayi Valyl-tRNA synthetase 0.0011 0.0015 0.0026
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Brugia malayi sulfakinin receptor protein 0.0016 0.0052 0.0094
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.014 0.095 0.1715
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.0502 0.0502
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0241 0.2694
Trypanosoma cruzi DNA repair protein, putative 0.0018 0.0067 0.0235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0297 0.0297
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0038 0.0212 0.0906
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0038 0.0212 0.0906
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0014 0.0038 0.0749
Schistosoma mansoni ankyrin 23/unc44 0.0014 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0344
Schistosoma mansoni hypothetical protein 0.0014 0.0038 0.0038
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0038 0.0212 0.0769
Trichomonas vaginalis guanylate cyclase, putative 0.0015 0.0046 0.0373
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0502 0.0907
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.0502 0.0502
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0075 0.0479 0.1712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0038 0.0282
Loa Loa (eye worm) hypothetical protein 0.0109 0.0726 0.111
Loa Loa (eye worm) hypothetical protein 0.0769 0.5536 0.8599
Onchocerca volvulus 0.0014 0.0038 0.0116
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0202 0.0294
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0014 0.0038 0.0038
Onchocerca volvulus 0.0016 0.0052 0.0182
Loa Loa (eye worm) phosphatidylinositol 3 0.0075 0.0479 0.0726
Brugia malayi nuclear receptor NHR-67 0.0037 0.0202 0.0364
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0052 0.0052
Echinococcus granulosus chromobox protein 1 0.0068 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) ABC transporter transmembrane region family protein 0.0014 0.0035 0.0035
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0075 0.0479 0.0479
Brugia malayi hypothetical protein 0.0024 0.0106 0.0191
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Onchocerca volvulus 0.0016 0.0052 0.0182
Leishmania major ATP-binding cassette protein subfamily C, member 2, putative 0.0014 0.0035 0.0112
Trichomonas vaginalis cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Schistosoma mansoni dihydroorotate dehydrogenase 0.0324 0.2295 0.2295
Trichomonas vaginalis cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative 0.0041 0.023 0.2558
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus granulosus poly adp ribose polymerase 2 0.0115 0.0774 0.0774
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0115 0.0774 0.0774
Echinococcus multilocularis epidermal growth factor receptor 0.0149 0.1021 0.1021
Brugia malayi coiled-coil like protein 1 0.0024 0.0106 0.0191
Giardia lamblia MRP-like ABC transporter 0.0014 0.0035 0.0687
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0038 0.0212 0.0769
Loa Loa (eye worm) hypothetical protein 0.0051 0.0302 0.0451
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0293 0.2065 0.3729
Echinococcus multilocularis serotonin receptor 0.0016 0.0052 0.0052
Schistosoma mansoni zinc finger protein 0.0037 0.0202 0.0202
Echinococcus multilocularis chromobox protein 1 0.0068 0.043 0.043
Brugia malayi chromobox protein homolog 3 0.0038 0.0212 0.0382
Brugia malayi Protein cec-1. 0.0011 0.0015 0.0026
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0024 0.0106 0.0191
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0202 0.0202
Brugia malayi hypothetical protein 0.0037 0.0202 0.0364
Loa Loa (eye worm) hypothetical protein 0.0014 0.0035 0.0035
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0293 0.2065 0.2065
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Echinococcus multilocularis ATP binding cassette sub family G 0.001 0.0004 0.0004
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.0127 0.0855 0.6913
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0052 0.0052
Echinococcus granulosus Sterile alpha motif SAM 0.0024 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0003
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0149
Schistosoma mansoni tyrosine kinase 0.0038 0.0208 0.0208
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0038 0.0212 0.0906
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.0014 0.0036 0.0036
Loa Loa (eye worm) phosphatidylinositol 3 0.0075 0.0479 0.0726
Entamoeba histolytica protein kinase rad3, putative 0.0042 0.0241 0.1923
Loa Loa (eye worm) pax transcription factor protein 2 0.0235 0.1649 0.2547
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0059
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0048 0.0286 0.0286
Schistosoma mansoni nAChR subunit 0.0293 0.2065 0.2065
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Brugia malayi nuclear receptor RXR 0.0041 0.0234 0.0422
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.0324 0.2295 1
Trichomonas vaginalis cone cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0293 0.2065 0.2065
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0201 0.1396 0.1396
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0276
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0293 0.2065 0.3194
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0038 0.0212 0.0778
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0201 0.1396 0.2522
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0297 0.1276
Brugia malayi hypothetical protein 0.014 0.095 0.1715
Leishmania major hypothetical protein, conserved 0.0018 0.0067 0.0226
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0014 0.0038 0.0038
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.014 0.095 0.1715
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0297 0.3352
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.001 0.0004 0.0004
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.0324 0.2295 0.8582
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0052 0.0052
Schistosoma mansoni thyroid hormone receptor 0.0201 0.1399 0.1399
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0011 0.0015 0.0045
Trypanosoma brucei multidrug resistance protein E 0.0014 0.0035 0.0136
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0014 0.0038 0.0149
Schistosoma mansoni adenoreceptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.0015 0.0003
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0127 0.0855 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0293 0.2065 0.3729
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0201 0.1396 0.2522
Schistosoma mansoni aryl hydrocarbon receptor 0.0173 0.119 0.119
Echinococcus granulosus liprin alpha 2 0.0024 0.0106 0.0106
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0297 0.0297
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0202 0.0364
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0202 0.0364
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.014 0.095 0.1715
Schistosoma mansoni hypothetical protein 0.0067 0.042 0.042
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0293 0.2065 0.3729
Entamoeba histolytica hypothetical protein 0.0011 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0018 0.0066 0.0083
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0011 0.0015 0.0015
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0014 0.0038 0.0038
Schistosoma mansoni hypothetical protein 0.0015 0.0046 0.0046
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.0127 0.0855 1
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0293 0.2065 0.2065
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0052 0.0052
Trichomonas vaginalis adenylate cyclase, putative 0.0015 0.0046 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.0502 0.0762
Echinococcus multilocularis SAM domain containing protein 0.0024 0.0106 0.0106
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0047 0.0276 0.1187
Entamoeba histolytica hypothetical protein 0.0035 0.019 0.1506
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.1075 0.7767 0.7767
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.0502 0.0502
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.0502 0.0907
Loa Loa (eye worm) hypothetical protein 0.0047 0.0276 0.041
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0052 0.0052
Schistosoma mansoni tyrosine kinase 0.0048 0.0286 0.0286
Echinococcus granulosus tyrosine protein kinase Blk 0.0034 0.0182 0.0182
Trichomonas vaginalis high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative 0.0026 0.0125 0.1317
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0052 0.0052
Onchocerca volvulus Putative nachr subunit 0.0293 0.2065 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0052 0.0094
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.005 0.005
Toxoplasma gondii hypothetical protein 0.0052 0.0315 0.1355
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) CYP4Cod1 0.0056 0.034 0.0509
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.005 0.005
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0014 0.0038 0.0038
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0297 0.3352
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0014 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Schistosoma mansoni opsin-like receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0015 0.0046 0.0156
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0038 0.0212 0.0906
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0502 0.0907
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0059
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0014 0.0038 0.0149
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.0324 0.2295 0.4145
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0038 0.0212 0.0769
Echinococcus multilocularis netrin receptor unc 5 0.0014 0.0036 0.0036
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.005 0.005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0038 0.0212 0.0906
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0015 0.0045
Mycobacterium leprae Conserved hypothetical protein 0.0038 0.0212 0.0769
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0014 0.0038 0.0282
Loa Loa (eye worm) hypothetical protein 0.0016 0.005 0.0059
Leishmania major cytochrome p450-like protein 0.0056 0.034 0.1209
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0276
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Echinococcus granulosus carbonic anhydrase 0.0109 0.0726 0.0726
Schistosoma mansoni nuclear receptor 0.0037 0.0202 0.0202
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0297 0.1053
Schistosoma mansoni opsin-like receptor 0.0016 0.0052 0.0052
Brugia malayi putative neuropeptide receptor 0.0016 0.0052 0.0094
Brugia malayi hypothetical protein 0.0041 0.0234 0.0422
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0016 0.0052 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0287 0.3243
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0026 0.0125 0.0226
Brugia malayi hypothetical protein 0.0012 0.0018 0.0033
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0052 0.0052
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0293 0.2065 0.3729
Entamoeba histolytica ATP-binding cassette protein, putative 0.0014 0.0035 0.0253
Onchocerca volvulus 0.0016 0.0052 0.0182
Loa Loa (eye worm) hypothetical protein 0.0024 0.0106 0.0145
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0056 0.034 0.1464
Brugia malayi aryl hydrocarbon receptor AHR-1 0.0113 0.0753 0.136
Schistosoma mansoni acetylcholine receptor subunit beta 0.014 0.095 0.095
Schistosoma mansoni hypothetical protein 0.0015 0.0046 0.0046
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0208 0.0208
Brugia malayi Cation transporter family protein 0.0293 0.2065 0.3729
Schistosoma mansoni hypothetical protein 0.0166 0.1141 0.1141
Echinococcus multilocularis protein dispatched 1 0.0047 0.0277 0.0277
Echinococcus granulosus chromobox protein 1 0.0068 0.043 0.043
Loa Loa (eye worm) hypothetical protein 0.0078 0.0502 0.0762
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Schistosoma mansoni thyroid hormone receptor 0.0201 0.1399 0.1399
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0009
Schistosoma mansoni jun-related protein 0.0067 0.042 0.042
Echinococcus granulosus g protein coupled receptor 0.0016 0.0052 0.0052
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.014 0.095 0.095
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0052 0.0052
Entamoeba histolytica hypothetical protein 0.0014 0.0038 0.0276
Leishmania major phosphatidylinositol kinase related protein, putative 0.0014 0.0038 0.0123
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0123 0.0831 0.0831
Brugia malayi hypothetical protein 0.014 0.095 0.1715
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0115 0.0774 0.0774
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.019 0.019
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0075 0.0479 0.1712
Onchocerca volvulus 0.014 0.095 0.4561
Schistosoma mansoni hypothetical protein 0.0038 0.0212 0.0212
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.0502 0.2378
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0052 0.0052
Schistosoma mansoni nuclear receptor 0.0037 0.0202 0.0202
Plasmodium falciparum carbonic anhydrase 0.0109 0.0726 0.3149
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Leishmania major phosphatidylinositol 3-kinase, putative 0.0014 0.0038 0.0123
Leishmania major hypothetical protein, unknown function 0.0014 0.0038 0.0123
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0106
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0127 0.0855 0.0855
Loa Loa (eye worm) ACC-1 protein 0.0293 0.2065 0.3194
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0014 0.0038 0.0123
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0208 0.0208
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0052 0.0061
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0014 0.0038 0.0038
Schistosoma mansoni biogenic amine receptor 0.0016 0.0052 0.0052
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.004 0.0224 0.0224
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0133 0.0904 0.0904
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0234 0.2614
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0202 0.0202
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0052 0.0052
Brugia malayi hypothetical protein 0.0065 0.0403 0.0729
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.0018 0.0067 0.0274
Onchocerca volvulus 0.0078 0.0502 0.2378
Onchocerca volvulus 0.0037 0.0202 0.0912
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0046 0.0373
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0038 0.0212 0.0769
Schistosoma mansoni neurotransmitter gated ion channel 0.014 0.095 0.095
Loa Loa (eye worm) tnks protein 0.0254 0.1787 0.2762
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Schistosoma mansoni jumonji/arid domain-containing protein 0.006 0.0372 0.0372
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0234 0.0234
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0052 0.0052
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0014 0.0038 0.0069
Brugia malayi hypothetical protein 0.0016 0.0052 0.0094
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.0026 0.0125 0.1317
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0293 0.2065 0.2065
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0052 0.0052
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0293 0.2065 0.3729
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0014 0.0038 0.0038
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Loa Loa (eye worm) hypothetical protein 0.0041 0.0234 0.0344
Echinococcus multilocularis glycine receptor subunit beta 0.0293 0.2065 0.2065
Brugia malayi Uncoordinated protein 44 0.0018 0.0063 0.0113
Echinococcus granulosus poly (ADP ribose) polymerase 0.0022 0.0092 0.0092
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.01 0.0663 0.0663
Onchocerca volvulus 0.003 0.0152 0.0668
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0038 0.0212 0.0906
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.0502 0.0502
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0042 0.0241 0.0241
Trypanosoma cruzi target of rapamycin kinase 3 0.0075 0.0479 0.1779
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0234 0.0422
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.0053 0.0096
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0293 0.2065 0.2065
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0052 0.0052
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0297 0.1095
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0038 0.0212 0.0769
Loa Loa (eye worm) hypothetical protein 0.0011 0.0015 0.0003
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0075 0.0479 0.1712
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0038 0.0212 0.0906
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0042 0.0241 0.0887
Onchocerca volvulus 0.0016 0.0052 0.0182
Mycobacterium ulcerans putative regulatory protein 0.0019 0.0072 0.0295
Brugia malayi cytochrome P450 0.0038 0.0212 0.0383
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0502 0.0907
Brugia malayi Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative 0.0026 0.0125 0.0226
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.005 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0502 0.0907
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0052 0.0052
Brugia malayi Cation transporter family protein 0.0293 0.2065 0.3729
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0075 0.0479 0.0865
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0015 0.0039 0.0039
Trypanosoma cruzi cytochrome P450, putative 0.0056 0.034 0.1257
Schistosoma mansoni myosin xvIII 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Loa Loa (eye worm) hypothetical protein 0.0107 0.0713 0.109
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0293 0.2065 0.3194
Trichomonas vaginalis cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0015 0.0046 0.0373
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0136 0.1445
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0075 0.0479 0.2073
Brugia malayi AKH receptor 0.0016 0.0052 0.0094
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0042 0.0241 0.0241
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Echinococcus multilocularis serotonin receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0202 0.0202
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0293 0.2065 0.2065
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0052 0.0061
Schistosoma mansoni amine GPCR 0.0016 0.0052 0.0052
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0184 0.1276 0.555
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0109 0.0726 0.1311
Echinococcus granulosus serine protein kinase ATM 0.0042 0.0241 0.0241
Loa Loa (eye worm) hypothetical protein 0.0109 0.0726 0.111
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.0502 0.2378
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Giardia lamblia Phosphatidylinositol 4-kinase 0.0014 0.0038 0.0749
Trypanosoma cruzi hypothetical protein 0.0011 0.0011 0.0025
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.0502 0.0907
Toxoplasma gondii target of rapamycin (TOR), putative 0.0075 0.0479 0.2073
Schistosoma mansoni tyrosine kinase 0.0038 0.0208 0.0208
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0014 0.0038 0.0038
Schistosoma mansoni tyrosine kinase 0.0079 0.0508 0.0508
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0153 0.1048 0.1048
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0052 0.0052
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0052 0.0182
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0052 0.0052
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.043 0.0649
Schistosoma mansoni hypothetical protein 0.0015 0.0046 0.0046
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0293 0.2065 0.2065
Loa Loa (eye worm) hypothetical protein 0.014 0.095 0.1458
Trichomonas vaginalis chromobox protein, putative 0.0068 0.043 0.4939
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0052 0.0052
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0052 0.0052
Loa Loa (eye worm) hypothetical protein 0.0037 0.0202 0.0294
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.0502 0.0502
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0202 0.0912
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.0015 0.0045
Onchocerca volvulus 0.0047 0.0277 0.128
Loa Loa (eye worm) phosphatidylinositol 3 0.0014 0.0038 0.004
Echinococcus granulosus tyrosine protein kinase Src42A 0.0032 0.0168 0.0168
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0297 0.1053
Echinococcus granulosus carbonic anhydrase 0.0109 0.0726 0.0726
Mycobacterium leprae conserved hypothetical protein 0.0019 0.0072 0.0149
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0038 0.0212 0.0906
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0293 0.2065 0.3194
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.0015 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Echinococcus granulosus glycine receptor subunit alpha 1 0.0293 0.2065 0.2065
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0052 0.0052
Schistosoma mansoni amine GPCR 0.0016 0.0052 0.0052
Leishmania major ATP-binding cassette protein subfamily C, member 6, putative 0.0014 0.0035 0.0112
Schistosoma mansoni hypothetical protein 0.0024 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0293 0.2065 0.3194
Echinococcus granulosus carbonic anhydrase 0.0109 0.0726 0.0726
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0014 0.0038 0.0282
Echinococcus granulosus phd:f box containing protein 0.0016 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0125 0.0175
Schistosoma mansoni tyrosine kinase 0.0081 0.0521 0.0521
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Echinococcus granulosus tumor protein p63 0.0677 0.4862 0.4862
Echinococcus multilocularis carbonic anhydrase 0.0109 0.0726 0.0726
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0011 0.0015 0.0045
Echinococcus multilocularis tankyrase 0.0278 0.1956 0.1956
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.0502 0.0907
Echinococcus multilocularis cAMP and cAMP inhibited cGMP 3',5' cyclic 0.0026 0.0125 0.0125
Loa Loa (eye worm) hypothetical protein 0.0153 0.1048 0.1612
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein 0.0014 0.0035 0.0136
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.0502 0.0502
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0075 0.0479 0.2073
Echinococcus multilocularis tyrosine protein kinase Srms 0.0034 0.0182 0.0182
Entamoeba histolytica hypothetical protein 0.0049 0.0287 0.2298
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Trypanosoma cruzi cAMP specific phosphodiesterase, putative 0.0041 0.023 0.0844
Leishmania major dihydroorotate dehydrogenase 0.0324 0.2295 0.8258
Echinococcus multilocularis somatostatin receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis multidrug resistance associated protein 7 0.0014 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Schistosoma mansoni histamine h1 receptor 0.0016 0.0052 0.0052
Echinococcus multilocularis geminin 0.0166 0.1141 0.1141
Trichomonas vaginalis calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative 0.006 0.0368 0.4205
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0016 0.0049 0.0168
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.0015 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Trichomonas vaginalis cGMP-dependent 3,5-cyclic phosphodiesterase, putative 0.006 0.0368 0.4205
Trypanosoma cruzi hypothetical protein, conserved 0.0376 0.2673 1
Schistosoma mansoni neurotransmitter gated ion channel 0.0153 0.1048 0.1048
Brugia malayi bZIP transcription factor family protein 0.0082 0.0532 0.0961
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0082 0.0532 0.0532
Loa Loa (eye worm) hypothetical protein 0.0038 0.0212 0.031
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0038 0.0212 0.0769
Trichomonas vaginalis PIKK family atypical protein kinase 0.0014 0.0038 0.0282
Trichomonas vaginalis PIKK family atypical protein kinase 0.0075 0.0479 0.5524
Schistosoma mansoni neuropeptide receptor 0.0016 0.0052 0.0052
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.0502 0.0502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061
Toxoplasma gondii hypothetical protein 0.0019 0.0072 0.0295
Brugia malayi Melibiase family protein 0.0067 0.042 0.0759
Schistosoma mansoni amine GPCR 0.0016 0.0052 0.0052
Loa Loa (eye worm) GABA receptor subunit 0.0153 0.1048 0.1612
Echinococcus granulosus tyrosine protein kinase HCK 0.003 0.0155 0.0155
Loa Loa (eye worm) hypothetical protein 0.0016 0.0052 0.0061

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.28 uM Inhibition of trypsin like activity of the proteasome purified from lymphoblastoid cell lines (in vitro) ChEMBL. 16033282
IC50 (binding) = 2.45 uM Inhibition of chymotrypsin like activity of the proteasome purified from lymphoblastoid cell lines (in vitro) ChEMBL. 16033282
IC50 (binding) > 10 uM Inhibition of post-acidic-like (PGPH) activity of the proteasome purified from lymphoblastoid cell lines (in vitro) ChEMBL. 16033282
T1/2 (ADMET) = 292 min Half-life of the compound was determined in human plasma by incubation at 370 C ChEMBL. 16033282
T1/2 (ADMET) > 360 min Half-life of the compound was determined in culturemedium (RPMI) in the presence of 10% foetal calf serum by incubation at 370 C ChEMBL. 16033282

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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