Detailed information for compound 338867

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 512.394 | Formula: C29H22BrNO3
  • H donors: 0 H acceptors: 0 LogP: 6.67 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 2
  • SMILES: Brc1ccc2c(c1)[C@H]1O[C@@H](C[C@H]1c1c(O2)cccc1)Cn1oc2c1cc(cc2)c1ccccc1
  • InChi: 1S/C29H22BrNO3/c30-20-11-13-27-24(15-20)29-23(22-8-4-5-9-26(22)33-27)16-21(32-29)17-31-25-14-19(10-12-28(25)34-31)18-6-2-1-3-7-18/h1-15,21,23,29H,16-17H2/t21-,23-,29-/m0/s1
  • InChiKey: DAXVXFQMYFUFSM-PLIGCNLOSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Rattus norvegicus Nociceptin receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni neuropeptide F-like receptor Nociceptin receptor   367 aa 301 aa 19.6 %
Echinococcus granulosus thyrotropin releasing hormone receptor Nociceptin receptor   367 aa 320 aa 26.2 %
Echinococcus granulosus allatostatin A receptor Nociceptin receptor   367 aa 304 aa 29.9 %
Onchocerca volvulus Nociceptin receptor   367 aa 334 aa 25.4 %
Onchocerca volvulus Nociceptin receptor   367 aa 322 aa 26.4 %
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Nociceptin receptor   367 aa 301 aa 27.9 %
Schistosoma mansoni peptide (allatostatin)-like receptor Nociceptin receptor   367 aa 297 aa 33.0 %
Onchocerca volvulus Nociceptin receptor   367 aa 352 aa 24.7 %
Onchocerca volvulus Nociceptin receptor   367 aa 299 aa 23.7 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Nociceptin receptor   367 aa 328 aa 25.6 %
Loa Loa (eye worm) neuropeptide F receptor Nociceptin receptor   367 aa 311 aa 24.4 %
Onchocerca volvulus Nociceptin receptor   367 aa 294 aa 24.8 %
Onchocerca volvulus Nociceptin receptor   367 aa 341 aa 21.1 %
Echinococcus multilocularis allatostatin A receptor Nociceptin receptor   367 aa 315 aa 28.9 %
Onchocerca volvulus Phospholipase d-related homolog Nociceptin receptor   367 aa 317 aa 20.8 %
Echinococcus granulosus growth hormone secretagogue receptor type 1 Nociceptin receptor   367 aa 319 aa 22.9 %
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Nociceptin receptor   367 aa 303 aa 23.8 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Nociceptin receptor   367 aa 320 aa 25.9 %
Onchocerca volvulus Programmed cell death protein 5 homolog Nociceptin receptor   367 aa 334 aa 23.1 %
Brugia malayi ORL1-like opioid receptor Nociceptin receptor   367 aa 294 aa 25.5 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Nociceptin receptor   367 aa 380 aa 20.0 %
Schistosoma mansoni adenoreceptor Nociceptin receptor   367 aa 325 aa 23.7 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Nociceptin receptor   367 aa 349 aa 23.8 %
Onchocerca volvulus E3 ubiquitin-protein ligase rpm-1 homolog Nociceptin receptor   367 aa 315 aa 20.6 %
Brugia malayi GnHR receptor homolog Nociceptin receptor   367 aa 308 aa 19.5 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Nociceptin receptor   367 aa 396 aa 24.2 %
Brugia malayi putative neuropeptide receptor NPR1 Nociceptin receptor   367 aa 300 aa 26.7 %
Loa Loa (eye worm) hypothetical protein Nociceptin receptor   367 aa 313 aa 26.5 %
Onchocerca volvulus Nociceptin receptor   367 aa 342 aa 25.4 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Nociceptin receptor   367 aa 347 aa 22.5 %
Schistosoma japonicum Rhodopsin, putative Nociceptin receptor   367 aa 335 aa 23.9 %
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor Nociceptin receptor   367 aa 330 aa 21.8 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Nociceptin receptor   367 aa 366 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis centaurin beta, putative 0.0079 0.0092 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.01 0.0131 0.0104
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0073 0.0109
Leishmania major protein kinase, putative 0.0069 0.0073 0.0042
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni serine/threonine-protein kinase 0.01 0.0131 0.0122
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) TK/DDR protein kinase 0.0048 0.0033 0.0029
Trypanosoma cruzi aurora B kinase, putative 0.0061 0.0058 0.0026
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.0033 0.0035
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0069 0.0073 0.0082
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0061 0.0058 0.0068
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0079 0.0092 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Onchocerca volvulus Protein melted homolog 0.0079 0.0092 0.0425
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0084 0.0101 0.0091
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0161
Loa Loa (eye worm) cytohesin 3 0.0079 0.0092 0.0088
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0088
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Trichomonas vaginalis centaurin/arf, putative 0.0079 0.0092 0.0249
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus plexin a4 0.0917 0.1682 0.2006
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0048 0.0033 0.009
Entamoeba histolytica protein kinase, putative 0.0061 0.0058 0.0068
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0079 0.0092 0.0082
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1967 0.3675 1
Echinococcus granulosus Pleckstrin y 0.0079 0.0092 0.0105
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0079 0.0092 0.0062
Trypanosoma brucei rac serine-threonine kinase, putative 0.01 0.0131 0.0104
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni semaphorin 5-related 0.0327 0.0563 0.0553
Echinococcus multilocularis regulator of G protein signaling 0.0859 0.1573 0.1875
Loa Loa (eye worm) hypothetical protein 0.0446 0.0789 0.0786
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1573 0.4279
Echinococcus granulosus integrin linked protein kinase 0.0048 0.0033 0.0035
Echinococcus multilocularis DCC interacting protein 13 beta 0.0079 0.0092 0.0105
Brugia malayi Regulator of G protein signaling domain containing protein 0.0859 0.1573 0.1569
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni protein kinase 0.0069 0.0073 0.0063
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi hypothetical protein 0.0048 0.0033 0.0029
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0048 0.0033 0.0035
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0048 0.0033 0.0035
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0079 0.0092 0.0249
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.0033 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.5298 1 1
Brugia malayi A-kinase anchor protein 10, precursor 0.0859 0.1573 0.1569
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0033 0.0035
Brugia malayi Oxysterol binding protein 0.0079 0.0092 0.0088
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0092 0.0062
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0859 0.1573 0.1565
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0097
Loa Loa (eye worm) hypothetical protein 0.0088 0.0109 0.0105
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Plasmodium falciparum dihydroorotate dehydrogenase 0.5037 0.9503 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0131 0.027
Trypanosoma cruzi NIMA-related kinase, putative 0.01 0.0131 0.0104
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.0033 0.0029
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0069 0.0073 0.0042
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0079 0.0092 0.0105
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0033 0.0035
Echinococcus multilocularis tyrosine kinase 0.0048 0.0033 0.0035
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.0062
Trichomonas vaginalis protein tyrosine kinase, putative 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Fibronectin type III domain containing protein 0.0088 0.0109 0.0105
Echinococcus multilocularis plexin a4 0.0917 0.1682 0.2006
Brugia malayi integrin-linked kinase 0.0048 0.0033 0.0029
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0033 0.0023
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 0.5037 0.9503 0.5
Echinococcus granulosus pdz domain containing protein 0.0079 0.0092 0.0105
Brugia malayi hypothetical protein 0.0079 0.0092 0.0088
Toxoplasma gondii Oxysterol-binding protein 0.0079 0.0092 0.0062
Schistosoma mansoni vesicular amine transporter 0.0086 0.0105 0.0095
Loa Loa (eye worm) G protein-coupled receptor kinase 1 0.4439 0.8369 0.8368
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Brugia malayi Serotonin receptor 0.0564 0.1013 0.1009
Echinococcus granulosus protein tyrosine kinase 0.0048 0.0033 0.0035
Onchocerca volvulus 0.0079 0.0092 0.0425
Loa Loa (eye worm) oxysterol binding protein 0.0079 0.0092 0.0088
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Onchocerca volvulus 0.0079 0.0092 0.0425
Echinococcus multilocularis tyrosine protein kinase shark 0.0048 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1573 0.4279
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis aurora kinase A 0.0061 0.0058 0.0065
Echinococcus multilocularis hypothetical protein 0.0327 0.0563 0.0668
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni protein kinase 0.0069 0.0073 0.0063
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi Sema domain containing protein 0.0327 0.0563 0.0559
Trypanosoma cruzi NIMA-related kinase, putative 0.01 0.0131 0.0104
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Entamoeba histolytica hypothetical protein 0.0143 0.0214 0.0496
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.0033 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0092 0.0062
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.01 0.0131 0.0104
Echinococcus granulosus tyrosine protein kinase Blk 0.0048 0.0033 0.0035
Brugia malayi Protein kinase domain containing protein 0.01 0.0131 0.0127
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi regulator of G-protein signaling rgs-7 0.0859 0.1573 0.1569
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.1967 0.3675 0.3846
Schistosoma mansoni z-protein (S1r protein) 0.0859 0.1573 0.1565
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0033 0.0035
Brugia malayi bone morphogenetic protein type 1 receptor 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Echinococcus granulosus axis inhibition protein axin 0.0859 0.1573 0.1875
Brugia malayi Immunoglobulin I-set domain containing protein 0.0132 0.0192 0.0188
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Echinococcus granulosus regulator of G protein signaling 3 0.0859 0.1573 0.1875
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 0.5037 0.9503 0.5
Leishmania major dihydroorotate dehydrogenase 0.5037 0.9503 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0033 0.009
Echinococcus multilocularis regulator of G protein signaling 7 0.0859 0.1573 0.1875
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0048 0.0033 0.0035
Onchocerca volvulus Putative zinc finger protein 0.0079 0.0092 0.0425
Entamoeba histolytica protein kinase domain containing protein 0.0191 0.0305 0.0746
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1967 0.3675 1
Onchocerca volvulus 0.0773 0.141 1
Loa Loa (eye worm) Plekhf2 protein 0.0079 0.0092 0.0088
Echinococcus granulosus aurora kinase A 0.0061 0.0058 0.0065
Echinococcus multilocularis integrin linked protein kinase 0.0048 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0327 0.0563 0.0559
Echinococcus granulosus raf serine:threonine protein kinase 0.0048 0.0033 0.0035
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Entamoeba histolytica ARF GTPase activating protein, putative 0.0079 0.0092 0.0161
Toxoplasma gondii AtPH1 family protein 0.0079 0.0092 0.0062
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1967 0.3675 1
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0079 0.0092 0.0425
Entamoeba histolytica hypothetical protein 0.01 0.0131 0.027
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0079 0.0092 0.0105
Brugia malayi regulator of G-protein signaling egl-10 0.0859 0.1573 0.1569
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0033 0.0035
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0058 0.0158
Schistosoma mansoni serine/threonine protein kinase 0.5298 1 1
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0061 0.0058 0.0065
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0079 0.0092 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Immunoglobulin I-set domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis hypothetical protein 0.0079 0.0092 0.0249
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Schistosoma mansoni regulator of G protein signaling 0.0859 0.1573 0.1565
Toxoplasma gondii hypothetical protein 0.0079 0.0092 0.0062
Echinococcus granulosus receptor type guanylyl cyclase 0.0048 0.0033 0.0035
Schistosoma mansoni hypothetical protein 0.0048 0.0033 0.0023
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Trichomonas vaginalis kinesin light chain, putative 0.0079 0.0092 0.0249
Echinococcus multilocularis exocyst complex component 2 0.0143 0.0214 0.0251
Echinococcus multilocularis oxysterol binding protein 1 0.0079 0.0092 0.0105
Trichomonas vaginalis centaurin/arf, putative 0.0079 0.0092 0.0249
Echinococcus granulosus tyrosine protein kinase ABL1 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0084 0.0101 0.0115
Schistosoma mansoni plexin 0.0446 0.0789 0.078
Loa Loa (eye worm) TK/EGFR protein kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis beta adrenergic receptor kinase 0.4061 0.7652 0.9142
Plasmodium vivax PH domain containing protein 0.0079 0.0092 0.0062
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.01 0.0131 0.0104
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0097
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Plasmodium falciparum PH domain-containing protein, putative 0.0079 0.0092 0.0062
Loa Loa (eye worm) sema domain-containing protein 0.0327 0.0563 0.0559
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0048 0.0033 0.0035
Loa Loa (eye worm) TK/ACK protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0079 0.0092 0.0082
Echinococcus granulosus tyrosine kinase 0.0048 0.0033 0.0035
Trypanosoma cruzi rac serine-threonine kinase, putative 0.01 0.0131 0.0104
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0061 0.0058 0.0065
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Onchocerca volvulus 0.0079 0.0092 0.0425
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis G protein coupled receptor kinase 1 0.3202 0.6021 0.7193
Echinococcus granulosus Oxysterol binding protein 11 0.0079 0.0092 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.0033 0.0035
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.01 0.0131 0.0358
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.5037 0.9503 0.9503
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0061 0.0058 0.0068
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.0033 0.0035
Echinococcus multilocularis Immunoglobulin 0.0084 0.0101 0.0115
Loa Loa (eye worm) SRC-1 0.0048 0.0033 0.0029
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0079 0.0092 0.0105
Brugia malayi probable spectrin beta chain 0.0079 0.0092 0.0088
Schistosoma mansoni protein tyrosine kinase 0.0048 0.0033 0.0023
Schistosoma mansoni cell adhesion molecule 0.0088 0.0109 0.0099
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative 0.5037 0.9503 1
Echinococcus granulosus oxysterol binding protein 3 0.0079 0.0092 0.0105
Echinococcus granulosus regulator of G protein signaling 7 0.0859 0.1573 0.1875
Schistosoma mansoni myotubularin-related protein 0.0079 0.0092 0.0082
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0048 0.0033 0.0029
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0131 0.027
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.5037 0.9503 0.9503
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0048 0.0033 0.0035
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0143 0.0214 0.0582
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0048 0.0033 0.0035
Echinococcus granulosus dynamin 1 0.0079 0.0092 0.0105
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0061 0.0058 0.0026
Echinococcus multilocularis activin receptor type 0.0069 0.0073 0.0082
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Loa Loa (eye worm) PXA domain-containing protein 0.0859 0.1573 0.1569
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis regulator of G protein signaling 7 0.0859 0.1573 0.1875
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0052 0.0041 0.0045
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0069 0.0073 0.0042
Entamoeba histolytica hypothetical protein 0.0143 0.0214 0.0496
Schistosoma mansoni vav2 0.0079 0.0092 0.0082
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni fibrocystin l 0.0143 0.0214 0.0204
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0079 0.0092 0.0249
Schistosoma mansoni goodpasture antigen-binding protein 0.0079 0.0092 0.0082
Trichomonas vaginalis protein kinase atn1, putative 0.0048 0.0033 0.009
Echinococcus granulosus tyrosine protein kinase Lyn 0.0069 0.0073 0.0082
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis alpha chimerin, putative 0.0079 0.0092 0.0249
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0033 0.0035
Brugia malayi Variant SH3 domain containing protein 0.0079 0.0092 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.4061 0.7652 0.7649
Echinococcus granulosus expressed protein 0.0859 0.1573 0.1875
Echinococcus granulosus protein kinase 0.0048 0.0033 0.0035
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0161
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1573 0.4279
Loa Loa (eye worm) TK/FAK protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1573 0.4279
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Echinococcus multilocularis neuroglian 0.0084 0.0101 0.0115
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.5037 0.9503 1
Echinococcus multilocularis GRB2 associated binding protein 3 0.0079 0.0092 0.0105
Echinococcus granulosus Pleckstrin y 0.0079 0.0092 0.0105
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0131 0.027
Schistosoma mansoni hypothetical protein 0.0143 0.0214 0.0204
Echinococcus granulosus regulator of G protein signaling 7 0.0859 0.1573 0.1875
Echinococcus multilocularis receptor type guanylyl cyclase 0.0048 0.0033 0.0035
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0161
Schistosoma mansoni tyrosine protein kinase 0.0048 0.0033 0.0023
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.01 0.0131 0.0104
Onchocerca volvulus 0.0327 0.0563 0.3845
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Echinococcus multilocularis cytohesin 1 0.0079 0.0092 0.0105
Trypanosoma cruzi Protein kinase B 0.01 0.0131 0.0104
Loa Loa (eye worm) hypothetical protein 0.0327 0.0563 0.0559
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi plexin A 0.0917 0.1682 0.1679
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0859 0.1573 0.1875
Echinococcus granulosus ephrin type A receptor 4 A 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) AGC/AKT protein kinase 0.01 0.0131 0.0127
Echinococcus multilocularis natriuretic peptide receptor 1 0.0048 0.0033 0.0035
Echinococcus granulosus serine/threonine protein kinase 0.01 0.0131 0.0152
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0161
Loa Loa (eye worm) hypothetical protein 0.0143 0.0214 0.021
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0058 0.0158
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus granulosus roundabout 2 0.0088 0.0109 0.0125
Schistosoma mansoni plexin 0.0773 0.141 0.1402
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0033 0.0035
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0132 0.0192 0.0188
Echinococcus granulosus regulator of G protein signaling 3 0.0859 0.1573 0.1875
Brugia malayi SRC-1 0.0048 0.0033 0.0029
Entamoeba histolytica hypothetical protein, conserved 0.0079 0.0092 0.0161
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus tyrosine kinase 0.0048 0.0033 0.0035
Loa Loa (eye worm) sema domain-containing protein 0.0327 0.0563 0.0559
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis semaphorin 5B 0.0327 0.0563 0.0668
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0161
Echinococcus granulosus activin receptor type 0.0069 0.0073 0.0082
Brugia malayi serine/threonine protein kinase 6 0.0061 0.0058 0.0054
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus DCC interacting protein 13 beta 0.0079 0.0092 0.0105
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative 0.5037 0.9503 1
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis raf serine:threonine protein kinase 0.0048 0.0033 0.0035
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Echinococcus granulosus beta 1 syntrophin 0.0079 0.0092 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trypanosoma brucei protein kinase, putative 0.0069 0.0073 0.0042
Brugia malayi IPT/TIG domain containing protein 0.0143 0.0214 0.021
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.0033 0.0029
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus granulosus beta-adrenergic receptor kinase 0.4061 0.7652 0.9142
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Echinococcus granulosus axis inhibition protein axin 0.0859 0.1573 0.1875
Trichomonas vaginalis TK family protein kinase 0.0048 0.0033 0.009
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0161
Entamoeba histolytica PH domain containing protein 0.0079 0.0092 0.0161
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0079 0.0092 0.0105
Schistosoma mansoni ephrin receptor 0.0052 0.0041 0.0032
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0082
Brugia malayi hypothetical protein 0.0048 0.0033 0.0029
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1967 0.3675 0.4389
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) hypothetical protein 0.0088 0.0109 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Brugia malayi PXA domain containing protein 0.0859 0.1573 0.1569
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus tyrosine protein kinase Srms 0.0048 0.0033 0.0035
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0859 0.1573 0.1565
Brugia malayi Plekhf2 protein 0.0079 0.0092 0.0088
Brugia malayi TBC domain containing protein 0.0079 0.0092 0.0088
Entamoeba histolytica cell surface protease gp63, putative 0.0143 0.0214 0.0496
Echinococcus multilocularis oxysterol binding protein 9 0.0079 0.0092 0.0105
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0079 0.0092 0.0105
Echinococcus granulosus natriuretic peptide receptor 1 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0048 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0143 0.0214 0.021
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0033 0.0035
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD 0.5037 0.9503 0.5
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0052 0.0041 0.0045
Echinococcus granulosus Rho GTPase activating protein 24 0.0079 0.0092 0.0105
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0079 0.0092 0.0082
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.01 0.0131 0.0104
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trypanosoma cruzi dihydroorotate dehydrogenase, putative 0.5037 0.9503 1
Brugia malayi Tyrosine-protein kinase PR2 0.0048 0.0033 0.0029
Echinococcus granulosus semaphorin 5B 0.0327 0.0563 0.0668
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0327 0.0563 0.0559
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0859 0.1573 0.1875
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0048 0.0033 0.0035
Schistosoma mansoni growth factor receptor-bound protein 0.0079 0.0092 0.0082
Echinococcus multilocularis tyrosine protein kinase HCK 0.0048 0.0033 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Trypanosoma brucei PH domain containing protein, putative 0.0079 0.0092 0.0062
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Trichomonas vaginalis dihydropyrimidine dehydrogenase, putative 0.1967 0.3675 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0033 0.0035
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0079 0.0092 0.0105
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0048 0.0033 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni hypothetical protein 0.0446 0.0789 0.078
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.4439 0.8369 0.8368
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0079 0.0092 0.0161
Loa Loa (eye worm) hypothetical protein 0.0859 0.1573 0.1569
Brugia malayi Uncoordinated protein 104 0.0079 0.0092 0.0088
Schistosoma mansoni serine/threonine protein kinase 0.4061 0.7652 0.7649
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.01 0.0131 0.0104
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis regulator of G protein signaling 3 0.0859 0.1573 0.1875
Loa Loa (eye worm) uncoordinated protein 104 0.0079 0.0092 0.0088
Leishmania major hypothetical protein, conserved 0.0079 0.0092 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0859 0.1573 0.4279
Onchocerca volvulus 0.0079 0.0092 0.0425
Brugia malayi Dynamin 0.0079 0.0092 0.0088
Plasmodium falciparum protein kinase, putative 0.0069 0.0073 0.0042
Schistosoma mansoni ephrin receptor 0.0048 0.0033 0.0023
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0033 0.0035
Loa Loa (eye worm) TK/EPH protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis protein KINase family member (kin 25) 0.0048 0.0033 0.0035
Echinococcus multilocularis oxysterol binding protein 3 0.0079 0.0092 0.0105
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0859 0.1573 0.1565
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Onchocerca volvulus 0.0079 0.0092 0.0425
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0079 0.0092 0.0088
Plasmodium falciparum serine/threonine protein kinase, putative 0.0061 0.0058 0.0026
Brugia malayi Pleckstrin Homology Domain 0.0079 0.0092 0.0088
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0061 0.0058 0.0068
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0079 0.0092 0.0062
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0069 0.0073 0.0082
Brugia malayi Cytohesin 3 0.0079 0.0092 0.0088
Schistosoma mansoni regulator of G protein signaling 0.0859 0.1573 0.1565
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0048 0.0033 0.0035
Loa Loa (eye worm) RGS-3 protein 0.0859 0.1573 0.1569
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD 0.5037 0.9503 0.5
Leishmania major serine/threonine-protein kinase a, putative 0.01 0.0131 0.0104
Brugia malayi Zinc finger, C2H2 type family protein 0.1967 0.3675 0.3673
Echinococcus multilocularis tyrosine protein kinase Blk 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus multilocularis Immunoglobulin 0.0084 0.0101 0.0115
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0079 0.0092 0.0062
Leishmania major protein kinase, putative 0.01 0.0131 0.0104
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1967 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0097
Brugia malayi Regulator of G protein signaling domain containing protein 0.0859 0.1573 0.1569
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0097
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0079 0.0092 0.0088
Echinococcus multilocularis Ras associated and pleckstrin y 0.0079 0.0092 0.0105
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) 0.5037 0.9503 1
Echinococcus granulosus tyrosine kinase 0.0048 0.0033 0.0035
Brugia malayi PXA domain containing protein 0.0859 0.1573 0.1569
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) TK/RYK protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0079 0.0092 0.0062
Echinococcus multilocularis transcription factor collier 0.0143 0.0214 0.0251
Trichomonas vaginalis centaurin alpha, putative 0.0079 0.0092 0.0249
Schistosoma mansoni zinc finger protein 0.0079 0.0092 0.0082
Echinococcus granulosus calcium dependent secretion activator 1 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Onchocerca volvulus 0.0079 0.0092 0.0425
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0048 0.0033 0.0035
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis Regulator of G protein signaling 20 0.0859 0.1573 0.1875
Schistosoma mansoni serine/threonine-protein kinase 0.01 0.0131 0.0122
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Schistosoma mansoni goodpasture antigen-binding protein 0.0079 0.0092 0.0082
Echinococcus multilocularis tyrosine protein kinase Srms 0.0048 0.0033 0.0035
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.01 0.0131 0.0104
Leishmania major folate/biopterin transporter, putative 0.01 0.0131 0.0104
Loa Loa (eye worm) hypothetical protein 0.0859 0.1573 0.1569
Onchocerca volvulus 0.0079 0.0092 0.0425
Echinococcus granulosus pleckstrin y domain containing family A 0.0079 0.0092 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Guanylyl cyclase protein 23 0.0048 0.0033 0.0029
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.01 0.0131 0.0104
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0069 0.0073 0.0042
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.0062
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0859 0.1573 0.1569
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Toxoplasma gondii aurora kinase 0.0061 0.0058 0.0026
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0058 0.0054
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) AUR protein kinase 0.0061 0.0058 0.0054
Loa Loa (eye worm) rho-GTPase-activating 0.0079 0.0092 0.0088
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0079 0.0092 0.0088
Echinococcus multilocularis heat shock protein 70 0.0048 0.0033 0.0035
Schistosoma mansoni dihydroorotate dehydrogenase 0.5037 0.9503 0.9503
Loa Loa (eye worm) protein kinase domain-containing protein 0.0048 0.0033 0.0029
Schistosoma mansoni axis inhibition protein axin 0.0859 0.1573 0.1565
Echinococcus granulosus exocyst complex component 2 0.0143 0.0214 0.0251
Echinococcus multilocularis tyrosine kinase 0.0048 0.0033 0.0035
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0048 0.0033 0.0035
Onchocerca volvulus outspread protein homolog 0.0079 0.0092 0.0425
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0082
Loa Loa (eye worm) hypothetical protein 0.0859 0.1573 0.1569
Echinococcus multilocularis regulator of G protein signaling 3 0.0859 0.1573 0.1875
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.01 0.0131 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0033 0.0035
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0327 0.0563 0.0559
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis ephrin type A receptor 4 A 0.0048 0.0033 0.0035
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Plasmodium falciparum oxysterol-binding protein, putative 0.0079 0.0092 0.0062
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0033 0.0035
Echinococcus multilocularis axis inhibition protein axin 0.0859 0.1573 0.1875
Echinococcus multilocularis tyrosine protein kinase pr2 0.0048 0.0033 0.0035
Echinococcus granulosus transcription factor collier 0.0143 0.0214 0.0251
Schistosoma mansoni protein kinase 0.0069 0.0073 0.0063
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0079 0.0092 0.0105
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK/ALK protein kinase 0.0241 0.0399 0.0395
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis AGC family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni rho gtpase activating protein 0.0079 0.0092 0.0082
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Brugia malayi Oxysterol-binding protein 0.0079 0.0092 0.0088
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.01 0.0131 0.0104
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.0062
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0079 0.0092 0.0249
Loa Loa (eye worm) TK/ROR protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus granulosus c src tyrosine kinase 0.0048 0.0033 0.0035
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0079 0.0092 0.0062
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.0058 0.0048
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni regulator of G protein signaling 0.0859 0.1573 0.1565
Echinococcus multilocularis tyrosine protein kinase Abl 0.0048 0.0033 0.0035
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0131 0.027
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0079 0.0092 0.0105
Toxoplasma gondii protein kinase domain-containing protein 0.01 0.0131 0.0104
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0088
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.01 0.0131 0.0104
Echinococcus granulosus twitchin 0.0105 0.014 0.0163
Echinococcus granulosus [G-protein-coupledreceptor] kinase 0.4439 0.8369 1
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Toxoplasma gondii phosphatidylinositol transfer protein 0.0079 0.0092 0.0062
Schistosoma mansoni axis inhibition protein axin 0.0859 0.1573 0.1565
Schistosoma mansoni oxysterol-binding protein 1 0.0079 0.0092 0.0082
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Echinococcus multilocularis kinase suppressor of Ras 1 0.0048 0.0033 0.0035
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0079 0.0092 0.0249
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Schistosoma mansoni protein kinase 0.0061 0.0058 0.0048
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0859 0.1573 0.1565
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.01 0.0131 0.0104
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Schistosoma mansoni dynamin 0.0079 0.0092 0.0082
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0048 0.0033 0.0035
Brugia malayi C-terminal src kinase protein 1 0.0048 0.0033 0.0029
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0079 0.0092 0.0105
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0079 0.0092 0.0249
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.0033 0.0035
Schistosoma mansoni centaurin alpha 0.0079 0.0092 0.0082
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.4439 0.8369 0.8368
Echinococcus granulosus oxysterol binding protein 1 0.0079 0.0092 0.0105
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0079 0.0092 0.0105
Echinococcus multilocularis rac serine:threonine kinase 0.01 0.0131 0.0152
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Schistosoma mansoni serine/threonine RGC 0.0048 0.0033 0.0023
Brugia malayi protein-tyrosine kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0079 0.0092 0.0105
Echinococcus multilocularis epidermal growth factor receptor 0.0048 0.0033 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis insulin receptor 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Giardia lamblia Aurora kinase 0.0061 0.0058 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0048 0.0033 0.0035
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0143 0.0214 0.0582
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Loa Loa (eye worm) hypothetical protein 0.0859 0.1573 0.1569
Trichomonas vaginalis STE family protein kinase 0.0048 0.0033 0.009
Brugia malayi serine/threonine-protein kinase 6 0.0061 0.0058 0.0054
Brugia malayi Sema domain containing protein 0.0327 0.0563 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Trypanosoma cruzi rac serine-threonine kinase, putative 0.01 0.0131 0.0104
Brugia malayi hypothetical protein 0.0327 0.0563 0.0559
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0033 0.009
Brugia malayi hypothetical protein 0.0088 0.0109 0.0105
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.017 0.0264 0.026
Echinococcus multilocularis c src tyrosine kinase 0.0048 0.0033 0.0035
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0079 0.0092 0.0062
Entamoeba histolytica p21-activated kinase 0.01 0.0131 0.027
Trypanosoma brucei protein kinase, putative 0.01 0.0131 0.0104
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus multilocularis roundabout 2 0.0088 0.0109 0.0125
Schistosoma mansoni hypothetical protein 0.0327 0.0563 0.0553
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0079 0.0092 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1573 0.4279
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0161
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0048 0.0033 0.0029
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi ephrin receptor 1 precursor 0.0048 0.0033 0.0029
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0079 0.0092 0.0161
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0773 0.141 0.1407
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0033 0.0029
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0033 0.0035
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Echinococcus multilocularis calcium dependent secretion activator 1 0.0079 0.0092 0.0105
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0048 0.0033 0.0023
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0161
Entamoeba histolytica tyrosin kinase, putative 0.0191 0.0305 0.0746
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0079 0.0092 0.0105
Echinococcus multilocularis protein kinase 0.0048 0.0033 0.0035
Entamoeba histolytica hypothetical protein 0.0859 0.1573 0.4227
Brugia malayi serine/threonine kinase 12 0.0061 0.0058 0.0054
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1967 0.3675 0.4389
Echinococcus granulosus tyrosine protein kinase pr2 0.0048 0.0033 0.0035
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0097
Echinococcus multilocularis transfer RNA-Thr 0.0048 0.0033 0.0035
Brugia malayi Dynamin 0.0079 0.0092 0.0088
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0079 0.0092 0.0105
Entamoeba histolytica protein kinase, putative 0.0061 0.0058 0.0068
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi hypothetical protein 0.0327 0.0563 0.0559
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Echinococcus granulosus defective proboscis extension response 0.0084 0.0101 0.0115
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Echinococcus multilocularis Oxysterol binding protein 11 0.0079 0.0092 0.0105
Schistosoma mansoni dynamin 0.0079 0.0092 0.0082
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.1967 0.3675 0.4389
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0048 0.0033 0.0035
Brugia malayi DNA-binding protein LAG-1 0.0143 0.0214 0.021
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0143 0.0214 0.0582
Echinococcus multilocularis protein kinase 0.0048 0.0033 0.0035
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0079 0.0092 0.0062
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0048 0.0033 0.009
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0079 0.0092 0.0105
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0033 0.0029
Echinococcus granulosus cytohesin 1 0.0079 0.0092 0.0105
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Schistosoma mansoni regulator of G protein signaling 0.0859 0.1573 0.1565
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0048 0.0033 0.0029
Echinococcus granulosus kinase suppressor of Ras 1 0.0048 0.0033 0.0035
Echinococcus multilocularis actin binding protein anillin 0.0079 0.0092 0.0105
Echinococcus granulosus epidermal growth factor receptor 0.0048 0.0033 0.0035
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) TK/Met protein kinase 0.0048 0.0033 0.0029
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Echinococcus granulosus oxysterol binding protein 9 0.0079 0.0092 0.0105
Echinococcus multilocularis dynamin 1 0.0079 0.0092 0.0105
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0048 0.0033 0.0029
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Entamoeba histolytica hypothetical protein 0.0079 0.0092 0.0161
Leishmania major protein kinase, putative 0.0061 0.0058 0.0026
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0048 0.0033 0.0035
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0048 0.0033 0.0023
Echinococcus granulosus G protein coupled receptor kinase 1 0.3202 0.6021 0.7193
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0048 0.0033 0.0035
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0033 0.0023
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.01 0.0131 0.0104
Echinococcus multilocularis axis inhibition protein axin 0.0859 0.1573 0.1875
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0033 0.0023
Trypanosoma cruzi PH domain containing protein, putative 0.0079 0.0092 0.0062
Echinococcus granulosus fibroblast growth factor receptor 4 0.0048 0.0033 0.0035
Echinococcus multilocularis Pleckstrin y 0.0079 0.0092 0.0105
Echinococcus multilocularis beta 1 syntrophin 0.0079 0.0092 0.0105
Loa Loa (eye worm) serine/threonine protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0327 0.0563 0.0559
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0048 0.0033 0.0035
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Echinococcus granulosus semaphorin 1A 0.0327 0.0563 0.0668
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Trypanosoma cruzi serine/threonine protein kinase, putative 0.01 0.0131 0.0104
Schistosoma mansoni hypothetical protein 0.0327 0.0563 0.0553
Trichomonas vaginalis conserved hypothetical protein 0.0859 0.1573 0.4279
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.1967 0.3675 0.4389
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Brugia malayi SH2 domain containing protein 0.0048 0.0033 0.0029
Entamoeba histolytica hypothetical protein 0.0859 0.1573 0.4227
Brugia malayi Raf kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis Pleckstrin y 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0327 0.0563 0.0559
Entamoeba histolytica dihydropyrimidine dehydrogenase, putative 0.1967 0.3675 1
Loa Loa (eye worm) hypothetical protein 0.0859 0.1573 0.1569
Toxoplasma gondii hypothetical protein 0.0079 0.0092 0.0062
Loa Loa (eye worm) hypothetical protein 0.0084 0.0101 0.0097
Brugia malayi hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0058 0.0158
Loa Loa (eye worm) TK/INSR protein kinase 0.0048 0.0033 0.0029
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0859 0.1573 0.1569
Trichomonas vaginalis protein transport protein sec7, putative 0.0079 0.0092 0.0249
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0088
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Echinococcus multilocularis Pleckstrin y 0.0079 0.0092 0.0105
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Entamoeba histolytica hypothetical protein 0.01 0.0131 0.027
Echinococcus granulosus tyrosine protein kinase csk 0.0048 0.0033 0.0035
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Entamoeba histolytica hypothetical protein 0.0859 0.1573 0.4227
Echinococcus granulosus GRB2 associated binding protein 3 0.0079 0.0092 0.0105
Entamoeba histolytica PH domain containing protein 0.0079 0.0092 0.0161
Brugia malayi Tyrosine-protein kinase abl-1 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis pleckstrin y domain containing family A 0.0079 0.0092 0.0105
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Echinococcus granulosus tyrosine protein kinase HCK 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Variant SH3 domain containing protein 0.0079 0.0092 0.0088
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Schistosoma mansoni zinc finger protein 0.0079 0.0092 0.0082
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Loa Loa (eye worm) hypothetical protein 0.0143 0.0214 0.021
Plasmodium falciparum calcium-dependent protein kinase 7 0.01 0.0131 0.0104
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Loa Loa (eye worm) PH domain-containing protein 0.0079 0.0092 0.0088
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.01 0.0131 0.0104
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) syntrophin-1 0.0079 0.0092 0.0088
Leishmania major hypothetical protein, conserved 0.0079 0.0092 0.0062
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Schistosoma mansoni oxysterol-binding protein 1 0.0079 0.0092 0.0082
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Brugia malayi Immunoglobulin I-set domain containing protein 0.0088 0.0109 0.0105
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0131 0.027
Loa Loa (eye worm) hypothetical protein 0.0143 0.0214 0.021
Echinococcus granulosus Pleckstrin y 0.0079 0.0092 0.0105
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0033 0.0035
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Echinococcus granulosus Regulator of G protein signaling 20 0.0859 0.1573 0.1875
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi hypothetical protein 0.0859 0.1573 0.1569
Schistosoma mansoni syntrophin 0.0079 0.0092 0.0082
Trypanosoma brucei aurora B kinase 0.0061 0.0058 0.0026
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0082
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0143 0.0214 0.0582
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Entamoeba histolytica PH domain containing protein kinase, putative 0.01 0.0131 0.027
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0084 0.0101 0.0091
Echinococcus multilocularis protein tyrosine kinase 0.0048 0.0033 0.0035
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0048 0.0033 0.009
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.4061 0.7652 0.7651
Trichomonas vaginalis conserved hypothetical protein 0.0079 0.0092 0.0249
Echinococcus multilocularis tyrosine protein kinase csk 0.0048 0.0033 0.0035
Loa Loa (eye worm) TK/CSK protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0082
Schistosoma mansoni protein kinase 0.0048 0.0033 0.0023
Entamoeba histolytica hypothetical protein 0.0143 0.0214 0.0496
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0069 0.0073 0.0042
Brugia malayi Cadps2 protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) plexin A 0.0917 0.1682 0.1679
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0079 0.0092 0.0425
Echinococcus multilocularis expressed protein 0.0859 0.1573 0.1875
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0048 0.0033 0.0035
Brugia malayi Probable exocyst complex component Sec5 0.0143 0.0214 0.021
Echinococcus granulosus Immunoglobulin 0.0084 0.0101 0.0115
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni hypothetical protein 0.0143 0.0214 0.0204
Loa Loa (eye worm) RGC/RGC protein kinase 0.0048 0.0033 0.0029
Schistosoma mansoni hypothetical protein 0.0079 0.0092 0.0082
Echinococcus granulosus retinal guanylyl cyclase 2 0.0048 0.0033 0.0035
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0084 0.0101 0.0115
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0033 0.0035
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0048 0.0033 0.0029
Echinococcus multilocularis Rho GTPase activating protein 24 0.0079 0.0092 0.0105
Brugia malayi hypothetical protein 0.0859 0.1573 0.1569
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi Protein kinase domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni nephrin 0.0088 0.0109 0.0099
Loa Loa (eye worm) TK/ABL protein kinase 0.0048 0.0033 0.0029
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0079 0.0092 0.0161
Trichomonas vaginalis centaurin gamma, putative 0.0079 0.0092 0.0249
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0079 0.0092 0.0088
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Brugia malayi Furin-like cysteine rich region family protein 0.0048 0.0033 0.0029
Echinococcus granulosus tyrosine protein kinase 0.0048 0.0033 0.0035
Brugia malayi MAX-1A 0.0079 0.0092 0.0088
Brugia malayi Syntrophin-1 0.0079 0.0092 0.0088
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.0058 0.0068
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0079 0.0092 0.0249
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Brugia malayi Protein kinase domain containing protein 0.0241 0.0399 0.0395
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative 0.5037 0.9503 1
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0048 0.0033 0.0029
Echinococcus granulosus tyrosine protein kinase shark 0.0048 0.0033 0.0035
Echinococcus granulosus myotubularin protein 13 0.0079 0.0092 0.0105
Loa Loa (eye worm) hypothetical protein 0.0048 0.0033 0.0029
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0079 0.0092 0.0082
Trichomonas vaginalis TKL family protein kinase 0.0048 0.0033 0.009
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus granulosus neuroglian 0.0084 0.0101 0.0115
Echinococcus multilocularis activated cdc42 kinase 1 0.0048 0.0033 0.0035
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0048 0.0033 0.0035
Entamoeba histolytica hypothetical protein 0.0143 0.0214 0.0496
Entamoeba histolytica protein kinase , putative 0.0061 0.0058 0.0068
Schistosoma mansoni serine/threonine protein kinase 0.0048 0.0033 0.0023
Echinococcus multilocularis tyrosine protein kinase 0.0048 0.0033 0.0035
Leishmania major protein kinase, putative 0.01 0.0131 0.0104
Brugia malayi Plexin repeat family protein 0.0773 0.141 0.1407
Echinococcus multilocularis FL cytokine receptor 0.0048 0.0033 0.0035
Trypanosoma cruzi hypothetical protein 0.0079 0.0092 0.0062
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0033 0.0035
Brugia malayi SH2 domain containing protein 0.0048 0.0033 0.0029
Trichomonas vaginalis Clan MA, family M8, leishmanolysin-like metallopeptidase 0.0143 0.0214 0.0582
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0048 0.0033 0.0023
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.01 0.0131 0.0358
Brugia malayi PH domain containing protein 0.0079 0.0092 0.0088
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0048 0.0033 0.0035
Entamoeba histolytica protein kinase, putative 0.01 0.0131 0.027
Schistosoma mansoni tyrosine kinase 0.0048 0.0033 0.0023
Loa Loa (eye worm) TK protein kinase 0.0048 0.0033 0.0029
Echinococcus multilocularis G protein coupled receptor kinase 6 0.4439 0.8369 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0033 0.0035
Echinococcus granulosus activated cdc42 kinase 1 0.0048 0.0033 0.0035
Trichomonas vaginalis dihydroorotate dehydrogenase, putative 0.1967 0.3675 1
Echinococcus multilocularis myotubularin protein 13 0.0079 0.0092 0.0105
Trichomonas vaginalis AGC family protein kinase 0.0061 0.0058 0.0158
Entamoeba histolytica PH domain containing protein 0.0079 0.0092 0.0161
Brugia malayi Receptor family ligand binding region containing protein 0.0048 0.0033 0.0029
Loa Loa (eye worm) TK/FER protein kinase 0.0048 0.0033 0.0029
Loa Loa (eye worm) hypothetical protein 0.0079 0.0092 0.0088
Loa Loa (eye worm) hypothetical protein 0.0088 0.0109 0.0105
Trichomonas vaginalis AGC family protein kinase 0.01 0.0131 0.0358
Echinococcus granulosus insulin receptor 0.0048 0.0033 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0143 0.0214 0.0582
Trichomonas vaginalis protein transport protein sec7, putative 0.0079 0.0092 0.0249
Echinococcus multilocularis pdz domain containing protein 0.0079 0.0092 0.0105
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0033 0.0035

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 183 nM In vitro binding affinity against 5-hydroxytryptamine 2C receptor using [3H]-mesulergine as radioligand expressed in CHO cells ChEMBL. 15911276
Ki (binding) = 183 nM In vitro binding affinity against 5-hydroxytryptamine 2C receptor using [3H]-mesulergine as radioligand expressed in CHO cells ChEMBL. 15911276
Ki (binding) = 307 nM In vitro binding affinity against 5-hydroxytryptamine 2A receptor using [125I]-R91150 as radioligand expressed in L929 cells ChEMBL. 15911276
Ki (binding) = 307 nM In vitro binding affinity against 5-hydroxytryptamine 2A receptor using [125I]-R91150 as radioligand expressed in L929 cells ChEMBL. 15911276
Ki (binding) = 4062 nM In vitro binding affinity against norepinephrin transpoter using [3H]-nisoxetine as radioligand ChEMBL. 15911276
Ki (binding) = 4062 nM In vitro binding affinity against norepinephrin transpoter using [3H]-nisoxetine as radioligand ChEMBL. 15911276

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.