Detailed information for compound 402285

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1965.26 | Formula: C90H141N29O21
  • H donors: 28 H acceptors: 22 LogP: -3.84 Rotable bonds: 77
    Rule of 5 violations (Lipinski): 4
  • SMILES: OC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N)Cc1ccc(cc1)O)CCCN=C(N)N)CCC(=O)N)CCCN=C(N)N)[C@H](O)C)C(C)C)CC(C)C)CC(=O)N)CC(C)C)Cc1cccc2c1cccc2)Cc1nc[nH]c1)CCCN=C(N)N)CC(C)C)NC(=O)[C@@H](NC(=O)C)C
  • InChi: 1S/C90H141N29O21/c1-44(2)34-62(113-85(138)68(42-120)117-74(127)48(9)105-50(11)122)79(132)107-58(23-16-32-102-89(96)97)77(130)115-66(39-54-41-100-43-104-54)82(135)114-65(38-53-20-14-19-52-18-12-13-21-56(52)53)81(134)111-63(35-45(3)4)80(133)116-67(40-70(92)125)83(136)112-64(36-46(5)6)84(137)118-71(47(7)8)86(139)119-72(49(10)121)87(140)109-59(24-17-33-103-90(98)99)75(128)108-60(29-30-69(91)124)78(131)106-57(22-15-31-101-88(94)95)76(129)110-61(73(93)126)37-51-25-27-55(123)28-26-51/h12-14,18-21,25-28,41,43-49,57-68,71-72,120-121,123H,15-17,22-24,29-40,42H2,1-11H3,(H2,91,124)(H2,92,125)(H2,93,126)(H,100,104)(H,105,122)(H,106,131)(H,107,132)(H,108,128)(H,109,140)(H,110,129)(H,111,134)(H,112,136)(H,113,138)(H,114,135)(H,115,130)(H,116,133)(H,117,127)(H,118,137)(H,119,139)(H4,94,95,101)(H4,96,97,102)(H4,98,99,103)/t48-,49+,57-,58-,59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,71-,72-/m0/s1
  • InChiKey: KJDWMBHDEAHCPN-OZWQXSJXSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Neuropeptide Y receptor type 2 Starlite/ChEMBL References
Homo sapiens neuropeptide Y receptor Y2 Starlite/ChEMBL References
Homo sapiens neuropeptide Y receptor Y1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus multilocularis G protein coupled receptor 139 Get druggable targets OG5_127863 All targets in OG5_127863
Echinococcus granulosus neuropeptide receptor Get druggable targets OG5_127863 All targets in OG5_127863
Schistosoma japonicum ko:K04209 neuropeptide Y receptor, invertebrate, putative Get druggable targets OG5_127863 All targets in OG5_127863
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Onchocerca volvulus Neuropeptide Y receptor type 2   381 aa 364 aa 24.5 %
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor Neuropeptide Y receptor type 2   381 aa 371 aa 20.8 %
Onchocerca volvulus Neuropeptide Y receptor type 2   381 aa 315 aa 23.5 %
Brugia malayi GnHR receptor homolog Neuropeptide Y receptor type 2   381 aa 346 aa 19.9 %
Onchocerca volvulus Neuropeptide Y receptor type 2   381 aa 308 aa 30.8 %
Onchocerca volvulus Neuropeptide Y receptor type 2   381 aa 307 aa 29.3 %
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Neuropeptide Y receptor type 2   381 aa 342 aa 23.7 %
Echinococcus multilocularis thyrotropin releasing hormone receptor Neuropeptide Y receptor type 2   381 aa 322 aa 25.8 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Neuropeptide Y receptor type 2   381 aa 353 aa 22.4 %
Echinococcus multilocularis growth hormone secretagogue receptor type 1 Neuropeptide Y receptor type 2   381 aa 313 aa 18.9 %
Echinococcus granulosus neuropeptide receptor Neuropeptide Y receptor type 2   381 aa 364 aa 22.8 %
Loa Loa (eye worm) follicle stimulating hormone receptor Neuropeptide Y receptor type 2   381 aa 321 aa 21.8 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor Neuropeptide Y receptor type 2   381 aa 370 aa 20.0 %
Brugia malayi follicle stimulating hormone receptor neuropeptide Y receptor Y1 384 aa 345 aa 22.0 %
Schistosoma japonicum ko:K04134 cholinergic receptor, invertebrate, putative Neuropeptide Y receptor type 2   381 aa 329 aa 22.5 %
Echinococcus granulosus pyroglutamylated rfamide peptide receptor neuropeptide Y receptor Y2 381 aa 388 aa 20.4 %
Echinococcus granulosus thyrotropin releasing hormone receptor Neuropeptide Y receptor type 2   381 aa 323 aa 25.7 %
Echinococcus multilocularis neuropeptide receptor fmrfamide receptor Neuropeptide Y receptor type 2   381 aa 361 aa 23.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum plasmepsin IX 0.0145 0.0211 0.0839
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Loa Loa (eye worm) hypothetical protein 0.0511 0.0843 0.1832
Brugia malayi calpain family protein 1 0.1029 0.1736 0.3784
Loa Loa (eye worm) programmed cell death protein 6 0.0049 0.0045 0.0088
Schistosoma mansoni adenoreceptor 0.0108 0.0146 0.0319
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0785 0.1315 0.2843
Echinococcus granulosus biogenic amine 5HT receptor 0.0108 0.0146 0.0146
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Trypanosoma brucei Component of motile flagella 41 0.0048 0.0044 0.0151
Echinococcus multilocularis hypothetical protein 0.0518 0.0854 0.0854
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0108 0.0146 0.0308
Giardia lamblia DINP protein human, muc B family 0.0039 0.0027 0.0088
Onchocerca volvulus 0.0108 0.0146 0.059
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0319 0.0511 0.2115
Toxoplasma gondii calcium-dependent protein kinase 0.0049 0.0045 0.0168
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 33 0.0048 0.0044 0.0151
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0007 0.0007
Leishmania major hypothetical protein, conserved 0.0048 0.0044 0.0108
Trypanosoma cruzi I/6 autoantigen, putative 0.0048 0.0044 0.0058
Loa Loa (eye worm) TK/ROR protein kinase 0.0134 0.0192 0.0408
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0123 0.0172 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0012 0.0016
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0031 0.0013 0.0027
Trichomonas vaginalis calmodulin-2, putative 0.0048 0.0044 0.0153
Brugia malayi Copper type II ascorbate-dependent monooxygenase, N-terminal domain containing protein 0.0316 0.0506 0.1095
Trypanosoma cruzi centrin, putative 0.0057 0.0058 0.0089
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0033 0.006
Giardia lamblia Hypothetical protein 0.0031 0.0013 0.0008
Trypanosoma cruzi prefoldin subunit, putative 0.0103 0.0138 0.0264
Brugia malayi Hypothetical RING finger protein F54G8.4 in chromosome III 0.0031 0.0013 0.0017
Leishmania major receptor-type adenylate cyclase a-like protein 0.0211 0.0324 0.125
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0233 0.0363 0.0783
Giardia lamblia Cysteine protease 0.0319 0.0511 0.2839
Echinococcus multilocularis musashi 0.0056 0.0057 0.0057
Onchocerca volvulus 0.0108 0.0146 0.059
Toxoplasma gondii 6-phosphofructokinase 0.003 0.0012 0.0027
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0319 0.0511 0.1115
Entamoeba histolytica cysteine proteinase, putative 0.076 0.1271 0.5303
Brugia malayi hypothetical protein 0.0051 0.0049 0.0095
Loa Loa (eye worm) hypothetical protein 0.0965 0.1626 0.3544
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0049 0.0069
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0027 0.0048
Onchocerca volvulus Cathepsin L homolog 0.0319 0.0511 0.2121
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0044 0.0044
Leishmania major cathepsin L-like protease 0.1406 0.2387 0.9661
Leishmania major hypothetical protein, conserved 0.0211 0.0324 0.125
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0073 0.0086 0.0187
Echinococcus granulosus Tolloid protein 1 0.0026 0.0005 0.0005
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0108 0.0146 0.0319
Toxoplasma gondii troponin c, isotype gamma, putative 0.0048 0.0044 0.0161
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0088 0.0155
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0079 0.0301
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Onchocerca volvulus 0.0042 0.0033 0.0115
Schistosoma mansoni hypothetical protein 0.0048 0.0044 0.0095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0001
Brugia malayi Serotonin receptor 0.0108 0.0146 0.0307
Entamoeba histolytica calmodulin, putative 0.0048 0.0044 0.0134
Trypanosoma cruzi calmodulin, putative 0.0048 0.0044 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Plasmodium falciparum serine repeat antigen 2 0.0319 0.0511 0.21
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0615 0.1022 0.4263
Brugia malayi B-box zinc finger family protein 0.0031 0.0013 0.0017
Trypanosoma brucei cysteine peptidase C (CPC) 0.1048 0.1769 0.7155
Plasmodium falciparum plasmepsin VIII, putative 0.0145 0.0211 0.0839
Echinococcus multilocularis neuropeptide receptor 0.0478 0.0785 0.0785
Giardia lamblia Cathepsin B precursor 0.0319 0.0511 0.2839
Echinococcus multilocularis programmed cell death protein 0.0057 0.0058 0.0058
Entamoeba histolytica hypothetical protein 0.0037 0.0024 0.0053
Echinococcus multilocularis peptidyl glycine alpha amidating monooxygenase 0.1174 0.1987 0.1987
Leishmania major cathepsin L-like protease 0.1406 0.2387 0.9661
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0075 0.0075
Schistosoma mansoni calcium binding atopy-related autoantigen 0.0049 0.0045 0.0099
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0363 0.0793
Trichomonas vaginalis calpain, putative 0.0262 0.0412 0.17
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Echinococcus multilocularis neuropeptide Y receptor 0.0108 0.0146 0.0146
Brugia malayi Tachykinin-like peptides receptor 99D 0.0108 0.0146 0.0307
Toxoplasma gondii aspartyl protease 0.0145 0.0211 0.0864
Schistosoma mansoni cathepsin F (C01 family) 0.1406 0.2387 0.5212
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0262 0.0412 0.17
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0319 0.0511 0.1105
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Onchocerca volvulus 0.0042 0.0033 0.0115
Plasmodium falciparum serine repeat antigen 9 0.0319 0.0511 0.21
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0108 0.0146 0.0319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0088 0.0181
Loa Loa (eye worm) calpain family protein 1 0.0773 0.1295 0.2819
Onchocerca volvulus 0.0048 0.0044 0.0161
Loa Loa (eye worm) CYP4Cod1 0.0033 0.0017 0.0027
Entamoeba histolytica calcium binding family protein 0.0048 0.0044 0.0134
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Schistosoma mansoni hypothetical protein 0.0066 0.0075 0.0164
Loa Loa (eye worm) hypothetical protein 0.0319 0.0511 0.1105
Echinococcus multilocularis allatostatin A receptor 0.0108 0.0146 0.0146
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0615 0.1022 0.2223
Toxoplasma gondii cathepsin CPC2 0.0319 0.0511 0.2121
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.0363 0.0363
Trichomonas vaginalis conserved hypothetical protein 0.0262 0.0412 0.17
Loa Loa (eye worm) hypothetical protein 0.2676 0.458 1
Onchocerca volvulus 0.0056 0.0057 0.0217
Onchocerca volvulus 0.1406 0.2387 1
Toxoplasma gondii microneme protein MIC4 0.0042 0.0033 0.0115
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0454 0.0744 0.2995
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0022
Echinococcus multilocularis neuropeptide Y receptor 0.0108 0.0146 0.0146
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0027 0.0027
Trypanosoma brucei Calpain-like protein 1.1 0.0817 0.1371 0.554
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0032 0.0111
Entamoeba histolytica cysteine proteinase, putative 0.1406 0.2387 1
Schistosoma mansoni hypothetical protein 0.0108 0.0146 0.0319
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0363 0.0793
Entamoeba histolytica calpain large subunit domain III containing protein 0.0256 0.0402 0.1642
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108 0.0146 0.0319
Echinococcus multilocularis programmed cell death protein 0.0057 0.0058 0.0058
Toxoplasma gondii kringle domain-containing protein 0.0134 0.0192 0.0782
Echinococcus granulosus calumenin 0.0049 0.0045 0.0045
Schistosoma mansoni cathepsin F (C01 family) 0.1406 0.2387 0.5212
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0428 0.0699 0.1518
Brugia malayi hypothetical protein 0.0145 0.0211 0.045
Trypanosoma cruzi calmodulin, putative 0.0048 0.0044 0.0058
Loa Loa (eye worm) hypothetical protein 0.0319 0.0511 0.1105
Onchocerca volvulus 0.0108 0.0146 0.059
Echinococcus multilocularis 6 phosphofructokinase 0.0111 0.0151 0.0151
Echinococcus granulosus brain tumor protein 0.0031 0.0013 0.0013
Echinococcus multilocularis cysteine protease 0.1406 0.2387 0.2387
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0088 0.0339
Brugia malayi hypothetical protein 0.0729 0.1219 0.2653
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1406 0.2387 1
Leishmania major hypothetical protein, conserved 0.0211 0.0324 0.125
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Schistosoma mansoni neuropeptide receptor 0.0108 0.0146 0.0319
Leishmania major DNA polymerase kappa, putative 0.0039 0.0027 0.004
Mycobacterium tuberculosis Probable conserved membrane protein 0.0031 0.0013 0.0058
Echinococcus granulosus cathepsin l1 0.0965 0.1626 0.1626
Schistosoma mansoni amine GPCR 0.0108 0.0146 0.0319
Echinococcus multilocularis Tolloid protein 1 0.0026 0.0005 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.0146 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0619 0.1028 0.2216
Trichomonas vaginalis Crustacean calcium-binding protein, putative 0.0048 0.0044 0.0153
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0088 0.1033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Echinococcus multilocularis fmrfamide receptor 0.0108 0.0146 0.0146
Schistosoma mansoni biogenic amine receptor 0.0108 0.0146 0.0319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.0511 0.1115
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0066 0.0145
Schistosoma mansoni neuropeptide F-like receptor 0.0108 0.0146 0.0319
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0319 0.0511 0.2115
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Schistosoma mansoni reticulocalbin 0.0048 0.0044 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Echinococcus multilocularis calumenin 0.0049 0.0045 0.0045
Schistosoma mansoni peptidylglycine monooxygenase 0.0624 0.1037 0.2263
Loa Loa (eye worm) hypothetical protein 0.0066 0.0075 0.0152
Brugia malayi RE15519p 0.0108 0.0146 0.0307
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0012 0.0018
Echinococcus granulosus serotonin receptor 0.0108 0.0146 0.0146
Brugia malayi chromobox protein homolog 3 0.0039 0.0027 0.0047
Echinococcus multilocularis cathepsin b 0.2676 0.458 0.458
Loa Loa (eye worm) hypothetical protein 0.1406 0.2387 0.5207
Echinococcus multilocularis cathepsin L 0.076 0.1271 0.1271
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Brugia malayi Papain family cysteine protease containing protein 0.1406 0.2387 0.5207
Brugia malayi Intermediate filament tail domain containing protein 0.0056 0.0057 0.0113
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Toxoplasma gondii microneme protein MIC17B 0.0042 0.0033 0.0115
Giardia lamblia Cathepsin L precursor 0.0319 0.0511 0.2839
Brugia malayi calpain 7 0.0518 0.0854 0.1854
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0049 0.0157
Onchocerca volvulus Cathepsin L homolog 0.1406 0.2387 1
Entamoeba histolytica calpain family cysteine protease, putative 0.0262 0.0412 0.1684
Brugia malayi B-box type zinc-finger protein ncl-1 0.0031 0.0013 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.1048 0.1769 0.7403
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0319 0.0511 0.21
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Trichomonas vaginalis calcium binding protein, putative 0.0048 0.0044 0.0153
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.007 0.014
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Echinococcus granulosus neuropeptides capa receptor 0.0108 0.0146 0.0146
Trypanosoma cruzi kinesin, putative 0.0256 0.0402 0.0843
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.076 0.1271 0.2776
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1077 0.182 0.3974
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0012 0.0018
Echinococcus granulosus calpain 5 0.0518 0.0854 0.0854
Leishmania major cathepsin L-like protease 0.1406 0.2387 0.9661
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.011 0.0151 0.1847
Trichomonas vaginalis conserved hypothetical protein 0.0319 0.0511 0.2115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0044 0.0084
Giardia lamblia Cathepsin B precursor 0.0319 0.0511 0.2839
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2676 0.458 1
Leishmania major hypothetical protein, conserved 0.0211 0.0324 0.125
Plasmodium falciparum plasmepsin V 0.0145 0.0211 0.0839
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0049 0.0069
Brugia malayi GnHR receptor homolog 0.0108 0.0146 0.0307
Schistosoma mansoni growth hormone secretagogue receptor 0.0108 0.0146 0.0319
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma cruzi mitochondrial calcium uptake 1, putative 0.0048 0.0044 0.0058
Schistosoma mansoni mitochondrial solute carrier 0.0048 0.0044 0.0095
Brugia malayi G protein-coupled receptor F59B2.13 0.0108 0.0146 0.0307
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0049 0.0157
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Trypanosoma brucei CAMK/CAMKL family protein kinase, putative 0.0048 0.0044 0.0151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0027 0.0027
Trypanosoma brucei protein I/6 0.0048 0.0044 0.0151
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0773 0.1295 0.521
Echinococcus granulosus programmed cell death protein 0.0057 0.0058 0.0058
Giardia lamblia Cathepsin L-like protease 0.0319 0.0511 0.2839
Trypanosoma brucei I/6 autoantigen 0.0048 0.0044 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0153
Echinococcus granulosus g protein coupled receptor 0.0108 0.0146 0.0146
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0454 0.0744 0.1593
Mycobacterium tuberculosis Probable oxidoreductase 0.0123 0.0172 0.2123
Leishmania major prefoldin subunit, putative 0.0103 0.0138 0.0491
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Onchocerca volvulus 0.0108 0.0146 0.059
Loa Loa (eye worm) papain family cysteine protease containing protein 0.1406 0.2387 0.5207
Brugia malayi neuropeptide F receptor 0.0108 0.0146 0.0307
Brugia malayi Hemopexin family protein 0.0033 0.0017 0.0024
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0151 0.0587
Trypanosoma cruzi cysteine peptidase, putative 0.0441 0.0721 0.1542
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0027 0.0065
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Plasmodium vivax unspecified product 0.0441 0.0721 0.2985
Entamoeba histolytica cysteine proteinase, putative 0.1406 0.2387 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.076 0.1271 0.2776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Schistosoma mansoni cathepsin S (C01 family) 0.0319 0.0511 0.1115
Schistosoma mansoni centrin 0.0048 0.0044 0.0095
Loa Loa (eye worm) cathepsin B 0.1048 0.1769 0.3856
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0108 0.0146 0.0146
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Schistosoma mansoni hypothetical protein 0.0053 0.0051 0.0112
Schistosoma mansoni chromobox protein 0.0069 0.0079 0.0173
Loa Loa (eye worm) G-protein coupled receptor 0.0108 0.0146 0.0308
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0319 0.0511 0.1115
Echinococcus multilocularis Mastin 0.0066 0.0075 0.0075
Trypanosoma cruzi cruzipain precursor, putative 0.1454 0.247 0.5376
Onchocerca volvulus 0.0108 0.0146 0.059
Mycobacterium ulcerans 6-phosphofructokinase 0.0111 0.0151 1
Echinococcus multilocularis serotonin receptor 0.0108 0.0146 0.0146
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0088 0.1033
Entamoeba histolytica cysteine proteinase 1, putative 0.076 0.1271 0.5303
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1048 0.1769 0.3863
Onchocerca volvulus 0.0108 0.0146 0.059
Echinococcus granulosus cathepsin l cysteine peptidase 0.1406 0.2387 0.2387
Echinococcus multilocularis dro:myosuppressin receptor 0.0108 0.0146 0.0146
Onchocerca volvulus 0.0108 0.0146 0.059
Leishmania major cytoskeleton-associated protein CAP5.5, putative,cysteine peptidase, Clan CA, family C2, putative 0.0472 0.0776 0.3091
Echinococcus multilocularis tripartite motif containing protein 3 0.0031 0.0013 0.0013
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0048 0.0044 0.0134
Leishmania major calcineurin B subunit, putative 0.0048 0.0044 0.0108
Giardia lamblia Encystation-specific protease 0.0319 0.0511 0.2839
Schistosoma mansoni chromobox protein 0.0069 0.0079 0.0173
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0029
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0049 0.0045 0.0062
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Echinococcus granulosus glycoprotein Antigen 5 0.0066 0.0075 0.0075
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0001
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0262 0.0412 0.17
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0319 0.0511 0.21
Loa Loa (eye worm) hypothetical protein 0.0325 0.0521 0.1129
Echinococcus granulosus enteropeptidase 0.0066 0.0075 0.0075
Schistosoma mansoni calmodulin 0.0048 0.0044 0.0095
Brugia malayi cathepsin L-like cysteine proteinase 0.0319 0.0511 0.1104
Brugia malayi Trypsin family protein 0.0066 0.0075 0.0152
Brugia malayi AKH receptor 0.0108 0.0146 0.0307
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.071 0.1186 0.2561
Echinococcus multilocularis family C2 unassigned peptidase (C02 family) 0.1077 0.182 0.182
Onchocerca volvulus 0.0056 0.0057 0.0217
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0027 0.0027
Schistosoma mansoni Sarcoplasmic calcium-binding protein (SCP). 0.0048 0.0044 0.0095
Toxoplasma gondii centrin 0.0048 0.0044 0.0161
Trypanosoma cruzi major cysteine proteinase, putative 0.0319 0.0511 0.1081
Echinococcus granulosus neuropeptides capa receptor 0.0108 0.0146 0.0146
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2676 0.458 1
Giardia lamblia Haloacid dehalogenase-like hydrolase family 0.0031 0.0013 0.0008
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0151 0.0604
Trypanosoma cruzi DNA polymerase eta, putative 0.0065 0.0072 0.012
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0151 0.0588
Echinococcus granulosus 7TM GPCR rhodopsin 0.0108 0.0146 0.0146
Plasmodium vivax glutathione reductase, putative 0.0048 0.0044 0.0134
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0319 0.0511 0.21
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0108 0.0146 0.0146
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Trypanosoma brucei centrin-3 0.0057 0.0058 0.0209
Leishmania major programmed cell death 6 protein-like protein 0.0048 0.0044 0.0108
Schistosoma mansoni cathepsin s 0.0441 0.0721 0.1574
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0233 0.0363 0.0782
Schistosoma mansoni amine GPCR 0.0108 0.0146 0.0319
Schistosoma mansoni neuronal calcium sensor 0.0048 0.0044 0.0095
Brugia malayi Cytochrome P450 family protein 0.0033 0.0017 0.0026
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0012 0.5
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0048 0.0044 0.0134
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0026 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0039 0.0027 0.0047
Onchocerca volvulus 0.0108 0.0146 0.059
Echinococcus multilocularis neuropeptide FF receptor 2 0.0108 0.0146 0.0146
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0042 0.0033 0.0115
Leishmania major DNA polymerase eta, putative 0.0065 0.0072 0.0224
Brugia malayi hypothetical protein 0.0124 0.0175 0.0371
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0324 0.0672
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0472 0.0776 0.1662
Loa Loa (eye worm) RING finger protein nhl-1 0.0031 0.0013 0.0017
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0308 0.0492 0.197
Echinococcus multilocularis calpain 5 0.0518 0.0854 0.0854
Mycobacterium ulcerans hypothetical protein 0.0066 0.0075 0.4646
Echinococcus granulosus alpha 1A adrenergic receptor 0.0108 0.0146 0.0146
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0472 0.0776 0.1662
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Loa Loa (eye worm) phosphofructokinase 0.0111 0.0151 0.0319
Schistosoma mansoni neuronal calcium sensor 0.0048 0.0044 0.0095
Onchocerca volvulus 0.0325 0.0521 0.2167
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0048 0.0044 0.0058
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0088 0.1033
Brugia malayi beta-lactamase 0.0074 0.0088 0.0181
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.0146 0.0319
Echinococcus multilocularis calpain A 0.1078 0.1822 0.1822
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma brucei unspecified product 0.0211 0.0324 0.1288
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0017 0.0027
Brugia malayi calpain 5 0.0262 0.0412 0.0888
Giardia lamblia Cysteine protease 0.0319 0.0511 0.2839
Giardia lamblia Cysteine protease 0.0319 0.0511 0.2839
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0151 0.0604
Echinococcus granulosus g-protein coupled receptor 0.0108 0.0146 0.0146
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0267 0.0421 0.1683
Echinococcus granulosus cathepsin L 0.076 0.1271 0.1271
Schistosoma mansoni reticulocalbin 0.0049 0.0045 0.0099
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0029
Onchocerca volvulus 0.0511 0.0843 0.3517
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Trypanosoma cruzi I/6 autoantigen, putative 0.0048 0.0044 0.0058
Onchocerca volvulus 0.0066 0.0075 0.0292
Brugia malayi Matrixin family protein 0.0056 0.0056 0.0111
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0817 0.1371 0.554
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0084 0.0105 0.0105
Brugia malayi cathepsin F-like cysteine proteinase 0.0319 0.0511 0.1104
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.0511 0.2115
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0044 0.0153
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0518 0.0854 0.1833
Plasmodium falciparum serine repeat antigen 3 0.0319 0.0511 0.21
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0817 0.1371 0.552
Onchocerca volvulus Matrilysin homolog 0.0051 0.0048 0.0181
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Leishmania major protein kinase, putative 0.0048 0.0044 0.0108
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0075 0.0164
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0033 0.006
Toxoplasma gondii cathepsin CPL 0.1406 0.2387 1
Toxoplasma gondii aspartyl protease ASP3 0.0145 0.0211 0.0864
Loa Loa (eye worm) EF hand family protein 0.0048 0.0044 0.0084
Echinococcus multilocularis transmembrane protease serine 3 0.0066 0.0075 0.0075
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0075 0.0164
Leishmania major calpain protease-like protein 0.0262 0.0412 0.1609
Mycobacterium tuberculosis Putative ferredoxin reductase 0.011 0.0151 0.1847
Loa Loa (eye worm) hypothetical protein 0.0965 0.1626 0.3544
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.0146 0.0146
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0045 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0066 0.0145
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.0146 0.0146
Trypanosoma brucei hypothetical protein, conserved 0.0341 0.0549 0.2204
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0027 0.009
Echinococcus granulosus Mastin 0.0066 0.0075 0.0075
Schistosoma mansoni thyroid hormone receptor 0.0139 0.02 0.0437
Echinococcus multilocularis G protein coupled receptor 139 0.0478 0.0785 0.0785
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.2676 0.458 1
Onchocerca volvulus 0.0259 0.0407 0.1685
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0211 0.0324 0.0672
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0615 0.1022 0.1022
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0108 0.0146 0.0307
Giardia lamblia Cathepsin L precursor 0.0319 0.0511 0.2839
Echinococcus granulosus calmodulin 0.0048 0.0044 0.0044
Plasmodium falciparum cysteine proteinase falcipain 1 0.076 0.1271 0.5303
Loa Loa (eye worm) TYRA-2 protein 0.0108 0.0146 0.0308
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0084 0.0105 0.0105
Leishmania major hypothetical protein, conserved 0.0341 0.0549 0.2169
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0027 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0066 0.0145
Trypanosoma brucei glucosamine 6-phosphate n-acetyltransferase 0.0262 0.0412 0.1646
Entamoeba histolytica grainin, putative 0.0049 0.0045 0.0141
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0145 0.0211 0.0864
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0108 0.0146 0.0308
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.0012 0.0027
Brugia malayi Heterochromatin protein 1 0.0069 0.0079 0.0161
Giardia lamblia Cathepsin B precursor 0.1048 0.1769 1
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0026 0.0086
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0108 0.0146 0.0307
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0027 0.0084
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Leishmania major cysteine peptidase A (CPA) 0.1406 0.2387 0.9661
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Onchocerca volvulus 0.1406 0.2387 1
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.0179 0.0379
Schistosoma mansoni biogenic amine receptor 0.0108 0.0146 0.0319
Leishmania major small myristoylated protein-3, putative 0.0308 0.0492 0.1934
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Toxoplasma gondii cathepsin B 0.1048 0.1769 0.7405
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0088 0.557
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0713 0.1191 0.4787
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0211 0.0324 0.0672
Echinococcus granulosus neuronal calcium sensor 0.0048 0.0044 0.0044
Loa Loa (eye worm) calpain D 0.0262 0.0412 0.0889
Onchocerca volvulus 0.0033 0.0017 0.0047
Brugia malayi ImpB/MucB/SamB family protein 0.0065 0.0072 0.0146
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0066 0.0066
Brugia malayi cathepsin L precursor 0.0319 0.0511 0.1104
Brugia malayi hypothetical protein 0.0066 0.0075 0.0152
Echinococcus granulosus chromobox protein 1 0.0069 0.0079 0.0079
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Onchocerca volvulus 0.0145 0.0211 0.0864
Onchocerca volvulus 0.0108 0.0146 0.059
Leishmania major kinesin, putative 0.0256 0.0402 0.1568
Trichomonas vaginalis conserved hypothetical protein 0.0319 0.0511 0.2115
Brugia malayi Pre-SET motif family protein 0.0061 0.0066 0.0133
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0108 0.0146 0.059
Echinococcus multilocularis calmodulin 0.0048 0.0044 0.0044
Loa Loa (eye worm) matrixin family protein 0.0051 0.0048 0.0095
Brugia malayi G-protein coupled receptor 0.0108 0.0146 0.0307
Leishmania major small myristoylated protein-2 0.0662 0.1103 0.4428
Brugia malayi hypothetical protein 0.0145 0.0211 0.045
Echinococcus multilocularis sarcoplasmic calcium binding protein 0.0048 0.0044 0.0044
Schistosoma mansoni calpain-7 (C02 family) 0.0518 0.0854 0.1864
Onchocerca volvulus 0.0042 0.0033 0.0115
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0027 0.0038
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0043 0.0082
Echinococcus multilocularis tissue type plasminogen activator 0.0134 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0773 0.1295 0.2819
Echinococcus granulosus cathepsin L cysteine protease 0.076 0.1271 0.1271
Leishmania major small myristoylated protein-1 0.0363 0.0588 0.2325
Schistosoma mansoni myosin xvIII 0.0108 0.0146 0.0319
Brugia malayi Papain family cysteine protease containing protein 0.076 0.1271 0.2767
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0211 0.0324 0.1288
Echinococcus granulosus neuropeptide s receptor 0.0108 0.0146 0.0146
Schistosoma mansoni memapsin-2 (A01 family) 0.0145 0.0211 0.0461
Onchocerca volvulus 0.0108 0.0146 0.059
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Trypanosoma brucei small myristoylated protein 1-2 0.0363 0.0588 0.2359
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.0776 0.1662
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.0012 0.0027
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0044 0.0058
Plasmodium falciparum prefoldin subunit 6, putative 0.0103 0.0138 0.053
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Loa Loa (eye worm) calpain family protein 1 0.1029 0.1736 0.3784
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.2676 0.458 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0619 0.1028 0.2216
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0151 0.033
Trypanosoma brucei Calpain-like protein CALP1.3 0.0472 0.0776 0.3122
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1077 0.182 0.3974
Plasmodium falciparum cysteine repeat modular protein 1 0.0134 0.0192 0.0757
Schistosoma mansoni hypothetical protein 0.0048 0.0044 0.0095
Toxoplasma gondii EF hand domain-containing protein 0.0048 0.0044 0.0161
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0319 0.0511 0.21
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Entamoeba histolytica cysteine proteinase, putative 0.0965 0.1626 0.6797
Loa Loa (eye worm) hypothetical protein 0.0441 0.0721 0.1565
Echinococcus granulosus tissue type plasminogen activator 0.0134 0.0192 0.0192
Echinococcus granulosus 6 phosphofructokinase 0.0111 0.0151 0.0151
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0319 0.0511 0.1115
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.2676 0.458 1
Toxoplasma gondii hypothetical protein 0.0042 0.0033 0.0115
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.0146 0.0319
Onchocerca volvulus 0.0965 0.1626 0.6806
Trypanosoma brucei small myristoylated protein 1-1 0.0363 0.0588 0.2359
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0615 0.1022 0.1022
Schistosoma mansoni amine GPCR 0.0108 0.0146 0.0319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.0511 0.1115
Brugia malayi Cathepsin L-like precursor 0.1406 0.2387 0.5207
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0319 0.0511 0.21
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0319 0.0511 0.2115
Brugia malayi Dopamine receptor protein 1 0.0108 0.0146 0.0307
Brugia malayi programmed cell death protein 6 0.0048 0.0044 0.0084
Mycobacterium leprae Probable lipase LipE 0.0074 0.0088 0.4866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Brugia malayi Papain family cysteine protease containing protein 0.0319 0.0511 0.1104
Trypanosoma brucei calpain, putative 0.0529 0.0873 0.3517
Toxoplasma gondii aspartyl protease ASP1 0.0615 0.1022 0.4268
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Loa Loa (eye worm) hypothetical protein 0.0134 0.0192 0.0408
Trichomonas vaginalis chromobox protein, putative 0.0069 0.0079 0.0301
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0026 0.0019
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0012 0.0014
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0074 0.0088 0.0181
Echinococcus multilocularis calpain 0.0518 0.0854 0.0854
Onchocerca volvulus 0.1406 0.2387 1
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0319 0.0511 0.21
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.076 0.1271 0.5134
Echinococcus multilocularis calbindin 32 0.0049 0.0045 0.0045
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.1174 0.1987 0.4332
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0088 0.1033
Leishmania major hypothetical protein, conserved 0.0051 0.0049 0.0129
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0108 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trichomonas vaginalis set domain proteins, putative 0.0487 0.0802 0.3337
Brugia malayi KE2 family protein 0.0103 0.0138 0.0289
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Trypanosoma cruzi cysteine peptidase, putative 0.076 0.1271 0.2749
Leishmania major calmodulin-like protein 0.0048 0.0044 0.0108
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Plasmodium falciparum plasmepsin VII 0.0145 0.0211 0.0839
Mycobacterium tuberculosis Conserved protein 0.0074 0.0088 0.1033
Brugia malayi Trypsin family protein 0.0325 0.0521 0.1128
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.0146 0.0146
Trypanosoma brucei DNA polymerase eta, putative 0.0065 0.0072 0.0267
Loa Loa (eye worm) hypothetical protein 0.0061 0.0066 0.0133
Echinococcus granulosus calpain 0.0518 0.0854 0.0854
Brugia malayi intermediate filament protein 0.0056 0.0057 0.0113
Trypanosoma cruzi programmed cell death 6 protein-like, putative 0.0048 0.0044 0.0058
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0026 0.0005 0.0001
Toxoplasma gondii hypothetical protein 0.0262 0.0412 0.1706
Schistosoma mansoni opsin-like receptor 0.0108 0.0146 0.0319
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0021 0.0034
Entamoeba histolytica hypothetical protein 0.0031 0.0013 0.0006
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0556 0.092 0.1978
Leishmania major centrin, putative,caltractin, putative 0.0048 0.0044 0.0108
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0049 0.0173
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0062 0.0062
Brugia malayi aspartic protease BmAsp-1, identical 0.0145 0.0211 0.045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Brugia malayi Cathepsin L-like precursor 0.1406 0.2387 0.5207
Echinococcus multilocularis cysteine protease 0.1406 0.2387 0.2387
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0027 0.0083
Echinococcus multilocularis laminin 0.0026 0.0005 0.0005
Plasmodium falciparum glutathione reductase 0.0048 0.0044 0.0134
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.011 0.0151 0.1847
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Onchocerca volvulus 0.0074 0.0088 0.0347
Echinococcus multilocularis dna polymerase eta 0.0065 0.0072 0.0072
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0066 0.0066
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0319 0.0511 0.2115
Echinococcus multilocularis sodium channel protein 0.0041 0.003 0.003
Echinococcus multilocularis calpain 7 (C02 family) 0.0518 0.0854 0.0854
Loa Loa (eye worm) B-box zinc finger family protein 0.0031 0.0013 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0027 0.0062
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0129 0.0182 0.0182
Leishmania major META domain containing protein 0.0211 0.0324 0.125
Echinococcus granulosus calcium uptake protein 1 0.0049 0.0045 0.0045
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Plasmodium falciparum serine repeat antigen 6 0.0319 0.0511 0.21
Echinococcus granulosus g protein coupled receptor 0.0108 0.0146 0.0146
Plasmodium falciparum serine repeat antigen 5 0.0319 0.0511 0.21
Schistosoma mansoni peptidyl-glycine monooxygenase 0.1174 0.1987 0.4338
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Schistosoma mansoni amine GPCR 0.0108 0.0146 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.0511 0.2115
Onchocerca volvulus 0.0108 0.0146 0.059
Trypanosoma brucei cysteine peptidase, putative 0.0472 0.0776 0.3122
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0028 0.0009 0.0007
Echinococcus granulosus EF HAND 1 calcium binding site 0.0048 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0262 0.0412 0.17
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0027 0.0048
Echinococcus granulosus calpain 7 C02 family 0.0518 0.0854 0.0854
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0084
Trypanosoma cruzi cytoskeleton-associated protein CAP5.5, putative 0.0472 0.0776 0.1662
Schistosoma mansoni intermediate filament proteins 0.0056 0.0057 0.0125
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0027 0.0062
Toxoplasma gondii calpain family cysteine protease domain-containing protein 0.0262 0.0412 0.1706
Echinococcus granulosus sarcoplasmic calcium binding protein 0.0048 0.0044 0.0044
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0319 0.0511 0.2115
Echinococcus multilocularis calcium uptake protein 1 0.0049 0.0045 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0063 0.007 0.0152
Brugia malayi 6-phosphofructokinase 0.0111 0.0151 0.0319
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS18 0.0031 0.0013 0.0058
Schistosoma mansoni hypothetical protein 0.0066 0.0075 0.0164
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0027 0.004
Echinococcus multilocularis brain tumor protein 0.0031 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0615 0.1022 0.2223
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0033 0.006
Trichomonas vaginalis calcium binding protein, putative 0.0048 0.0044 0.0153
Echinococcus granulosus somatostatin receptor 0.0108 0.0146 0.0146
Plasmodium vivax aspartyl proteinase, putative 0.0145 0.0211 0.0839
Toxoplasma gondii preprocathepsin c precursor, putative 0.0319 0.0511 0.2121
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0088 0.0192
Onchocerca volvulus 0.0488 0.0802 0.3344
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0319 0.0511 0.21
Giardia lamblia Hypothetical protein 0.0049 0.0045 0.0191
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0145 0.0211 0.045
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0082
Brugia malayi Papain family cysteine protease containing protein 0.0319 0.0511 0.1104
Plasmodium vivax aspartyl protease, putative 0.0145 0.0211 0.0839
Leishmania major phospholipase c-like protein 0.0048 0.0044 0.0108
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108 0.0146 0.0319
Brugia malayi putative neuropeptide receptor NPR1 0.0108 0.0146 0.0307
Echinococcus multilocularis glycoprotein Antigen 5 0.0066 0.0075 0.0075
Brugia malayi Melatonin receptor type 1A 0.0108 0.0146 0.0307
Onchocerca volvulus 0.0066 0.0075 0.0292
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Trypanosoma brucei calmodulin, putative 0.0048 0.0044 0.0151
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0027 0.0084
Trypanosoma cruzi Domain of unknown function (DUF1935), putative 0.0211 0.0324 0.0672
Plasmodium vivax SET domain protein, putative 0.0061 0.0066 0.0229
Plasmodium vivax aspartyl protease, putative 0.0145 0.0211 0.0839
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0518 0.0854 0.1833
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0032 0.0103
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0026 0.0005 0.0001
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.039 0.0633 0.135
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0027 0.1252
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0785 0.1315 0.5289
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0088 0.4866
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0026 0.0005 0.0012
Echinococcus granulosus EF hand domain containing family member A2 0.0048 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Toxoplasma gondii EFHC1, putative 0.0048 0.0044 0.0161
Trichomonas vaginalis DNA-dependent protein kinase catalytic subunit-interacting protein, putative 0.0048 0.0044 0.0153
Echinococcus multilocularis thyroid hormone receptor alpha 0.0139 0.02 0.02
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 33 0.0048 0.0044 0.0058
Mycobacterium tuberculosis Probable reductase 0.011 0.0151 0.1847
Echinococcus multilocularis lamin 0.0056 0.0057 0.0057
Trypanosoma cruzi cruzipain precursor, putative 0.0441 0.0721 0.1542
Trypanosoma cruzi unspecified product 0.0363 0.0588 0.125
Echinococcus granulosus lamin dm0 0.0056 0.0057 0.0057
Brugia malayi phosphofructokinase 0.0111 0.0151 0.0319
Giardia lamblia Cathepsin B precursor 0.0319 0.0511 0.2839
Schistosoma mansoni lamin 0.0056 0.0057 0.0125
Echinococcus multilocularis muscleblind protein 1 0.0154 0.0227 0.0227
Trypanosoma cruzi hypothetical protein, conserved 0.0341 0.0549 0.1166
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0012 0.0018
Onchocerca volvulus 0.0108 0.0146 0.059
Giardia lamblia Cathepsin B precursor 0.0319 0.0511 0.2839
Loa Loa (eye worm) hypothetical protein 0.0325 0.0521 0.1129
Brugia malayi TAR-binding protein 0.0063 0.007 0.014
Entamoeba histolytica hypothetical protein 0.0037 0.0024 0.0053
Schistosoma mansoni biogenic amine (5HT) receptor 0.0108 0.0146 0.0319
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Loa Loa (eye worm) hypothetical protein 0.0145 0.0211 0.045
Echinococcus granulosus hypothetical protein 0.0108 0.0146 0.0146
Leishmania major centrin, putative 0.0048 0.0044 0.0108
Plasmodium falciparum cysteine proteinase falcipain 2b 0.1406 0.2387 1
Onchocerca volvulus 0.0134 0.0192 0.0782
Echinococcus multilocularis centrin 2 0.0048 0.0044 0.0044
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0108 0.0146 0.0319
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0108 0.0146 0.0146
Entamoeba histolytica cysteine proteinase, putative 0.076 0.1271 0.5303
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0319 0.0511 0.2839
Leishmania major small myristoylated protein 4, putative 0.0573 0.0949 0.3798
Trypanosoma cruzi centrin-3 0.0057 0.0058 0.0089
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0033 0.0115
Schistosoma mansoni histamine h1 receptor 0.0108 0.0146 0.0319
Brugia malayi follicle stimulating hormone receptor 0.0108 0.0146 0.0307
Trypanosoma brucei calmodulin, putative 0.0049 0.0045 0.0158
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.0079 0.0162
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0473 0.0777 1
Entamoeba histolytica cysteine protease, putative 0.0319 0.0511 0.21
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0075 0.0164
Loa Loa (eye worm) calpain 0.0518 0.0854 0.1855
Echinococcus granulosus neuropeptide Y receptor 0.0108 0.0146 0.0146
Brugia malayi Cathepsin L-like precursor 0.1406 0.2387 0.5207
Trypanosoma brucei hypothetical protein 0.0529 0.0873 0.3517
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0308 0.0492 0.104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Schistosoma mansoni 6-phosphofructokinase 0.0111 0.0151 0.033
Echinococcus multilocularis g protein coupled receptor 0.0108 0.0146 0.0146
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0088 0.0339
Echinococcus granulosus peptidyl glycine alpha amidating monooxygenase 0.1174 0.1987 0.1987
Trichomonas vaginalis calcineurin B subunit, putative 0.0049 0.0045 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Schistosoma mansoni tar DNA-binding protein 0.0063 0.007 0.0152
Echinococcus granulosus muscleblind protein 0.0154 0.0227 0.0227
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0108 0.0146 0.0319
Entamoeba histolytica hypothetical protein 0.0037 0.0024 0.0053
Trypanosoma brucei Calpain-like protein 1.2 0.0619 0.1028 0.4148
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0027 0.008
Brugia malayi hypothetical protein 0.0037 0.0024 0.0042
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0319 0.0511 0.1105
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0441 0.0721 0.1564
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.076 0.1271 0.2776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.0363 0.0363
Schistosoma mansoni opsin-like receptor 0.0108 0.0146 0.0319
Brugia malayi glutathione reductase 0.0048 0.0044 0.0084
Loa Loa (eye worm) hypothetical protein 0.0441 0.0721 0.1565
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0017
Loa Loa (eye worm) hypothetical protein 0.0767 0.1285 0.2797
Echinococcus multilocularis lamin dm0 0.0056 0.0057 0.0057
Onchocerca volvulus Matrix metalloproteinase homolog 0.0051 0.0048 0.0181
Loa Loa (eye worm) hypothetical protein 0.0066 0.0075 0.0152
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0319 0.0511 0.21
Plasmodium vivax plasmepsin V, putative 0.0145 0.0211 0.0839
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0324 0.0672
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Toxoplasma gondii microneme protein, putative 0.0042 0.0033 0.0115
Brugia malayi aspartic protease BmAsp-2, identical 0.0145 0.0211 0.045
Brugia malayi larval opioid receptor 0.0108 0.0146 0.0307
Schistosoma mansoni neuropeptide F-like receptor 0.0108 0.0146 0.0319
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.0511 0.1115
Plasmodium vivax serine-repeat antigen (SERA) 0.0319 0.0511 0.21
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0211 0.0324 0.1288
Trypanosoma brucei unspecified product 0.0039 0.0027 0.0084
Schistosoma mansoni cathepsin F (C01 family) 0.0965 0.1626 0.3551
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0027 0.002
Schistosoma mansoni calmodulin related calcium binding protein 0.0048 0.0044 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Loa Loa (eye worm) hypothetical protein 0.0441 0.0721 0.1565
Brugia malayi beta-lactamase family protein 0.0074 0.0088 0.0181
Loa Loa (eye worm) hypothetical protein 0.0729 0.1219 0.2653
Echinococcus granulosus calpain A 0.0518 0.0854 0.0854
Loa Loa (eye worm) matrixin family protein 0.0056 0.0056 0.0112
Echinococcus multilocularis cathepsin b 0.2676 0.458 0.458
Onchocerca volvulus 0.0108 0.0146 0.059
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Brugia malayi MH2 domain containing protein 0.0127 0.0179 0.0378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Giardia lamblia Cathepsin B precursor 0.0319 0.0511 0.2839
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0027 0.0241
Loa Loa (eye worm) hypothetical protein 0.0965 0.1626 0.3544
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0267 0.0421 0.1683
Plasmodium vivax serine-repeat antigen (SERA) 0.0319 0.0511 0.21
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0066 0.0066
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Echinococcus granulosus dna polymerase eta 0.0065 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0048 0.0044 0.0084
Echinococcus multilocularis fibrillin 1 0.0026 0.0005 0.0005
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0262 0.0412 0.17
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0012 0.0018
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0033 0.0115
Trypanosoma brucei centrin, putative 0.0048 0.0044 0.0151
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0029
Echinococcus multilocularis G-protein coupled receptor, putative 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Schistosoma mansoni cathepsin C 0.0319 0.0511 0.1115
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108 0.0146 0.0146
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0108 0.0146 0.0308
Onchocerca volvulus 0.0066 0.0075 0.0292
Brugia malayi Papain family cysteine protease containing protein 0.076 0.1271 0.2767
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Schistosoma mansoni ap endonuclease 0.0038 0.0027 0.0058
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Brugia malayi B-box type zinc-finger protein ncl-1 0.0031 0.0013 0.0017
Toxoplasma gondii microneme protein MIC17C 0.0042 0.0033 0.0115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0454 0.0744 0.1593
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0044 0.0455
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Echinococcus granulosus cathepsin l1 0.1406 0.2387 0.2387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0033 0.0115
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Entamoeba histolytica prefoldin subunit 6, putative 0.0103 0.0138 0.053
Brugia malayi Kringle domain containing protein 0.0134 0.0192 0.0407
Echinococcus granulosus transmembrane protease serine 3 0.0066 0.0075 0.0075
Echinococcus multilocularis neuropeptide receptor 0.0108 0.0146 0.0146
Giardia lamblia Cathepsin L precursor 0.0319 0.0511 0.2839
Plasmodium vivax vivapain-2 0.1406 0.2387 1
Loa Loa (eye worm) hypothetical protein 0.0145 0.0211 0.045
Toxoplasma gondii exonuclease III APE 0.0038 0.0027 0.0088
Loa Loa (eye worm) fibroinase 0.1406 0.2387 0.5207
Schistosoma mansoni tar DNA-binding protein 0.0063 0.007 0.0152
Mycobacterium ulcerans beta-lactamase 0.0074 0.0088 0.557
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Loa Loa (eye worm) intermediate filament protein 0.0056 0.0057 0.0113
Schistosoma mansoni DNA polymerase eta 0.0065 0.0072 0.0158
Trypanosoma brucei antigen, putative 0.0518 0.0854 0.3438
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.076 0.1271 0.5312
Brugia malayi Cytochrome P450 family protein 0.0033 0.0017 0.0026
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0108 0.0146 0.0319
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0088 0.0088
Brugia malayi Trypsin family protein 0.0066 0.0075 0.0152
Loa Loa (eye worm) hypothetical protein 0.0066 0.0075 0.0152
Plasmodium falciparum plasmepsin II 0.0615 0.1022 0.4252
Onchocerca volvulus 0.1406 0.2387 1
Brugia malayi Papain family cysteine protease containing protein 0.0319 0.0511 0.1104
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.071 0.1186 0.4787
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0049 0.0183
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0108 0.0146 0.0146
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0088 0.557
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0033 0.0115
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.0776 0.1662
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0108 0.0146 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.1454 0.247 0.5376
Trichomonas vaginalis esterase, putative 0.0074 0.0088 0.0339
Plasmodium vivax vivapain-1 0.076 0.1271 0.5303
Schistosoma mansoni tar DNA-binding protein 0.0063 0.007 0.0152
Loa Loa (eye worm) hypothetical protein 0.0319 0.0511 0.1105
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0586 0.0972 0.2092
Schistosoma mansoni survival motor neuron protein 0.0048 0.0043 0.0094
Mycobacterium tuberculosis Probable dehydrogenase 0.011 0.0151 0.1847
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0027 0.13
Loa Loa (eye worm) hypothetical protein 0.0065 0.0072 0.0146
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0088 0.0155
Brugia malayi Trypsin family protein 0.0066 0.0075 0.0152
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0233 0.0363 0.0363
Schistosoma mansoni biogenic amine receptor 0.0108 0.0146 0.0319
Echinococcus granulosus calbindin 32 0.0049 0.0045 0.0045
Leishmania major i/6 autoantigen-like protein 0.0048 0.0044 0.0108
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0319 0.0511 0.1115
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Leishmania major hypothetical protein, conserved 0.0481 0.0791 0.3155
Plasmodium vivax vivapain-3 0.076 0.1271 0.5303
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0088 0.0192
Loa Loa (eye worm) trypsin family protein 0.0066 0.0075 0.0152
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0066 0.0075 0.0164
Onchocerca volvulus 0.0108 0.0146 0.059
Leishmania major calmodulin, putative 0.0048 0.0044 0.0108
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0088 0.0339
Loa Loa (eye worm) hypothetical protein 0.0051 0.0049 0.0096
Brugia malayi calpain D 0.0262 0.0412 0.0888
Echinococcus granulosus geminin 0.0356 0.0575 0.0575
Echinococcus multilocularis chromobox protein 1 0.0069 0.0079 0.0079
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0027 0.008
Trypanosoma brucei hypothetical protein, conserved 0.0048 0.0044 0.0151
Echinococcus granulosus cathepsin L cysteine proteinase 0.1406 0.2387 0.2387
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Onchocerca volvulus 0.016 0.0236 0.0969
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0022
Leishmania major hypothetical protein, conserved 0.0211 0.0324 0.125
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.1013 0.171 0.3709
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.007 0.0141
Schistosoma mansoni neuronal calcium sensor 0.0048 0.0044 0.0095
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Trypanosoma brucei calpain-like protein, putative 0.0518 0.0854 0.3438
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Brugia malayi beta-lactamase family protein 0.0074 0.0088 0.0181
Trichomonas vaginalis calcium binding protein, putative 0.0057 0.0058 0.0213
Mycobacterium ulcerans hypothetical protein 0.0074 0.0088 0.557
Schistosoma mansoni thyroid hormone receptor 0.0139 0.02 0.0437
Trypanosoma cruzi cysteine proteinase, putative 0.076 0.1271 0.2749
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0123 0.0172 0.2123
Plasmodium falciparum plasmepsin IV 0.0615 0.1022 0.4252
Loa Loa (eye worm) calpain 5 0.0256 0.0402 0.0867
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Loa Loa (eye worm) B-box zinc finger family protein 0.0031 0.0013 0.0017
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0586 0.0972 0.3892
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0033 0.006
Echinococcus granulosus chromobox protein 1 0.0069 0.0079 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.0511 0.2115
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0066 0.0075 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0319 0.0511 0.2115
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Onchocerca volvulus 0.1406 0.2387 1
Schistosoma mansoni egf-like domain protein 0.0026 0.0005 0.0012
Giardia lamblia Hypothetical protein 0.0103 0.0138 0.0716
Trichomonas vaginalis conserved hypothetical protein 0.0341 0.0549 0.2278
Loa Loa (eye worm) hypothetical protein 0.0154 0.0227 0.0484
Plasmodium falciparum plasmepsin III 0.0145 0.0211 0.0839
Echinococcus granulosus neuropeptide FF receptor 2 0.0108 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0048 0.0043 0.0094
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Loa Loa (eye worm) hypothetical protein 0.016 0.0236 0.0505
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0111 0.0151 1
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0066 0.0075 0.0152
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0773 0.1295 0.521
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0151 0.0319
Trypanosoma cruzi calpain cysteine peptidase, putative 0.0472 0.0776 0.1662
Brugia malayi Thioredoxin reductase 0.0048 0.0044 0.0084
Echinococcus granulosus cysteine protease 0.076 0.1271 0.1271
Giardia lamblia Cathepsin L precursor 0.0319 0.0511 0.2839
Entamoeba histolytica cysteine proteinase, putative 0.076 0.1271 0.5303
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0088 0.0331
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0027 0.0022
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0012 0.0015
Loa Loa (eye worm) hypothetical protein 0.0262 0.0412 0.0889
Loa Loa (eye worm) hypothetical protein 0.1029 0.1736 0.3784
Brugia malayi neuropeptide F receptor 0.0108 0.0146 0.0307
Leishmania major centrin, putative 0.0048 0.0044 0.0108
Echinococcus granulosus 7tm_1 domain containing protein 0.0108 0.0146 0.0146
Echinococcus granulosus dna polymerase kappa 0.0039 0.0027 0.0027
Trypanosoma cruzi calmodulin, putative 0.0048 0.0044 0.0058
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0134 0.0192 0.0757
Brugia malayi 6-phosphofructokinase 0.0111 0.0151 0.0319
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0441 0.0721 0.1565
Brugia malayi EF hand family protein 0.0049 0.0045 0.0087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0615 0.1022 0.2231
Leishmania major calpain family cysteine protease-like protein 0.0472 0.0776 0.3091
Entamoeba histolytica EF-hand calcium-binding domain containing protein 0.0048 0.0044 0.0134
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0151 0.0587
Schistosoma mansoni tar DNA-binding protein 0.0063 0.007 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0236 0.0367 0.0791
Loa Loa (eye worm) hypothetical protein 0.0056 0.0057 0.0113
Trichomonas vaginalis centrin, putative 0.0048 0.0044 0.0153
Brugia malayi Cathepsin L-like precursor 0.1406 0.2387 0.5207
Trypanosoma cruzi caltractin, putative 0.0048 0.0044 0.0058
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1406 0.2387 0.2387
Entamoeba histolytica cysteine protease, putative 0.1406 0.2387 1
Echinococcus multilocularis calpain family protein 1, d 0.0773 0.1295 0.1295
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0033 0.0115
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Loa Loa (eye worm) RNA binding protein 0.0063 0.007 0.0141
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.076 0.1271 0.5312
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0088 0.1033
Trypanosoma cruzi conserved protein 0.0481 0.0791 0.1696
Plasmodium falciparum cysteine proteinase falcipain 3 0.1406 0.2387 1
Onchocerca volvulus 0.0042 0.0033 0.0115
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0027 0.0082
Entamoeba histolytica cysteine protease, putative 0.0319 0.0511 0.21
Entamoeba histolytica protein kinase, putative 0.0256 0.0402 0.1642
Giardia lamblia Cathepsin L-like protease 0.0319 0.0511 0.2839
Schistosoma mansoni centrin-related 0.0048 0.0044 0.0095
Echinococcus granulosus cathepsin b 0.2676 0.458 0.458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Trypanosoma brucei kinesin, putative 0.0256 0.0402 0.1605
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Onchocerca volvulus 0.0048 0.0044 0.0161
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.076 0.1271 0.5134
Onchocerca volvulus 0.0042 0.0033 0.0115
Onchocerca volvulus 0.0042 0.0033 0.0115
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Brugia malayi calcium-binding protein 0.0048 0.0044 0.0084
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0108 0.0146 0.0146
Trypanosoma brucei prefoldin subunit, putative 0.0103 0.0138 0.0533
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0044 0.0044
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0817 0.1371 0.2968
Leishmania major DNA polymerase eta, putative 0.0038 0.0026 0.0035
Leishmania major hypothetical protein, conserved 0.0049 0.0045 0.0115
Brugia malayi cathepsin F-like cysteine proteinase 0.0441 0.0721 0.1564
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0049 0.0157
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0529 0.0873 0.3517
Brugia malayi Cathepsin L-like precursor 0.0965 0.1626 0.3544
Brugia malayi Trypsin-like protease protein 5 0.0066 0.0075 0.0152
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Loa Loa (eye worm) G-protein coupled receptor 0.0108 0.0146 0.0308
Brugia malayi Cathepsin L-like precursor 0.0441 0.0721 0.1564
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Toxoplasma gondii ABC1 family protein 0.0074 0.0088 0.0347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.0511 0.2115
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Schistosoma mansoni cathepsin D (A01 family) 0.1675 0.2851 0.6225
Echinococcus granulosus allatostatin A receptor 0.0108 0.0146 0.0146
Brugia malayi sulfakinin receptor protein 0.0729 0.1219 0.2653
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1048 0.1769 0.384
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0233 0.0363 0.0363
Echinococcus granulosus g protein coupled receptor 0.0108 0.0146 0.0146
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0785 0.1315 0.5309
Loa Loa (eye worm) hypothetical protein 0.0028 0.0009 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0308 0.0492 0.197
Brugia malayi Muscleblind-like protein 0.0154 0.0227 0.0483
Leishmania major cathepsin L-like protease 0.1406 0.2387 0.9661
Schistosoma mansoni calpain C (C02 family) 0.0518 0.0854 0.1864
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0027 0.0027
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0529 0.0873 0.3488
Echinococcus granulosus neuropeptide receptor 0.0108 0.0146 0.0146
Plasmodium falciparum serine repeat antigen 8 0.0319 0.0511 0.21
Echinococcus multilocularis brain tumor protein 0.0031 0.0013 0.0013
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0262 0.0412 0.17
Mycobacterium tuberculosis PE-PGRS family protein PE_PGRS17 0.0031 0.0013 0.0058
Echinococcus multilocularis EF hand domain containing family member A2 0.0048 0.0044 0.0044
Toxoplasma gondii hypothetical protein 0.0042 0.0033 0.0115
Onchocerca volvulus 0.0042 0.0033 0.0115
Loa Loa (eye worm) hypothetical protein 0.0319 0.0511 0.1105
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0027 0.0084
Echinococcus granulosus tm gpcr rhodopsin 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0027 0.0007 0.0004
Trypanosoma brucei trypanothione reductase 0.0048 0.0044 0.0151
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0001
Mycobacterium tuberculosis Conserved protein 0.0074 0.0088 0.1033
Loa Loa (eye worm) neuropeptide F receptor 0.0108 0.0146 0.0308
Echinococcus multilocularis prefoldin subunit 6 0.0103 0.0138 0.0138
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0017
Trypanosoma brucei calpain-like protein, putative 0.0785 0.1315 0.5309
Entamoeba histolytica calmodulin, putative 0.0048 0.0044 0.0134
Brugia malayi Cytochrome P450 family protein 0.0035 0.0021 0.0033
Onchocerca volvulus 0.0108 0.0146 0.059
Plasmodium vivax plasmepsin IV, putative 0.0615 0.1022 0.4252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0013 0.0017
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0319 0.0511 0.21
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0075 0.0164
Toxoplasma gondii PAN domain-containing protein 0.0042 0.0033 0.0115
Echinococcus multilocularis cathepsin L 0.0319 0.0511 0.0511
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Leishmania major cathepsin L-like protease 0.1454 0.247 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0108 0.0146 0.0319
Echinococcus granulosus neurocalcin 0.0048 0.0044 0.0044
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0108 0.0146 0.0146
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Entamoeba histolytica hypothetical protein 0.0319 0.0511 0.21
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0111 0.0151 0.1855
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0319 0.0511 0.2115
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.1406 0.2387 0.5207
Echinococcus granulosus tar DNA binding protein 0.0063 0.007 0.007
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0027 0.0062
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0108 0.0146 0.0319
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Echinococcus multilocularis neuropeptides capa receptor 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma cruzi cysteine peptidase, putative 0.1454 0.247 0.5376
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0586 0.0972 0.2092
Mycobacterium tuberculosis Conserved protein 0.0074 0.0088 0.1033
Trypanosoma brucei mitochondrial calcium uptake 1 0.0048 0.0044 0.0151
Loa Loa (eye worm) hypothetical protein 0.0319 0.0511 0.1105
Trypanosoma brucei variant surface glycoprotein (VSG), putative 0.0267 0.0421 0.1683
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0129 0.0182 0.0182
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0041 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0037 0.0024 0.0053
Trypanosoma brucei flagellum-adhesion glycoprotein, putative 0.0031 0.0013 0.0027
Schistosoma mansoni neuropeptide receptor 0.0108 0.0146 0.0319
Trypanosoma brucei cytochrome P450, putative 0.0033 0.0017 0.0044
Schistosoma mansoni hypothetical protein 0.0134 0.0192 0.0419
Plasmodium vivax vivapain-2 0.1406 0.2387 1
Schistosoma mansoni ap endonuclease 0.0038 0.0027 0.0058
Leishmania major ATP-dependent phosphofructokinase 0.0111 0.0151 0.0546
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0319 0.0511 0.21
Onchocerca volvulus 0.1406 0.2387 1
Onchocerca volvulus 0.003 0.0012 0.0029
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0088 0.0321
Schistosoma mansoni hypothetical protein 0.0356 0.0575 0.1255
Echinococcus granulosus survival motor neuron protein 1 0.0236 0.0367 0.0367
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0012 0.0018
Loa Loa (eye worm) hypothetical protein 0.0074 0.0088 0.0181
Echinococcus multilocularis survival motor neuron protein 1 0.0236 0.0367 0.0367
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0573 0.0949 0.2042
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trichomonas vaginalis Clan CA, family C2, calpain-like cysteine peptidase 0.0262 0.0412 0.17
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Loa Loa (eye worm) cytochrome P450 family protein 0.0033 0.0017 0.0027
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.0012 0.0018
Entamoeba histolytica cysteine proteinase, putative 0.076 0.1271 0.5303
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0066 0.0075 0.0075
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0233 0.0363 0.0793
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0027 0.0059
Echinococcus granulosus nuclear factor of activated T cells 5 0.0075 0.009 0.009
Trichomonas vaginalis calcium binding proteins, putative 0.0048 0.0044 0.0153
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0027 0.1056
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Onchocerca volvulus Cathepsin F homolog 0.1406 0.2387 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0319 0.0511 0.21
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Giardia lamblia Cathepsin L precursor 0.0319 0.0511 0.2839
Giardia lamblia Cysteine protease 0.0319 0.0511 0.2839
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Trypanosoma cruzi cysteine peptidase, putative 0.1406 0.2387 0.5194
Brugia malayi cathepsin L-like precursor 0.0965 0.1626 0.3544
Brugia malayi Pre-SET motif family protein 0.0428 0.0699 0.1517
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1682 0.2864 0.2864
Echinococcus granulosus intermediate filament protein 0.0056 0.0057 0.0057
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.1406 0.2387 1
Echinococcus granulosus sex peptide receptor 0.0108 0.0146 0.0146
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0319 0.0511 0.21
Loa Loa (eye worm) TAR-binding protein 0.0063 0.007 0.0141
Loa Loa (eye worm) NCL-1 protein 0.0031 0.0013 0.0017
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0088 0.1033
Onchocerca volvulus 0.0042 0.0033 0.0115
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0024 0.0053
Trypanosoma cruzi cysteine protease, putative 0.076 0.1271 0.2749
Onchocerca volvulus 0.0066 0.0075 0.0292
Loa Loa (eye worm) hypothetical protein 0.0074 0.0088 0.0181
Echinococcus granulosus lamin 0.0056 0.0057 0.0057
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0088 0.0339
Schistosoma mansoni hypothetical protein 0.0108 0.0146 0.0319
Plasmodium vivax centrin-1, putative 0.0048 0.0044 0.0134
Loa Loa (eye worm) calmodulin-like protein 0.0048 0.0044 0.0084
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0066 0.0075 0.0075
Echinococcus granulosus family C2 unassigned peptidase C02 family 0.1077 0.182 0.182
Echinococcus granulosus neuropeptide receptor A26 0.0108 0.0146 0.0146
Onchocerca volvulus 0.0042 0.0033 0.0115
Echinococcus multilocularis fmrfamide receptor 0.0108 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0108 0.0146 0.059
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Entamoeba histolytica cysteine protease, putative 0.0319 0.0511 0.21
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0324 0.0672
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0027 0.0059
Echinococcus granulosus G protein coupled receptor 139 0.0108 0.0146 0.0146
Schistosoma mansoni hypothetical protein 0.0103 0.0138 0.03
Trichomonas vaginalis centrin, putative 0.0048 0.0044 0.0153
Schistosoma mansoni lamin 0.0056 0.0057 0.0125
Leishmania major trypanothione reductase 0.0048 0.0044 0.0107
Brugia malayi ORL1-like opioid receptor 0.0108 0.0146 0.0307
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0108 0.0146 0.0319
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0319 0.0511 0.21
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.0511 0.1115
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0472 0.0776 0.1662
Echinococcus granulosus cathepsin L 0.0319 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0001
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trypanosoma cruzi centrin, putative 0.0057 0.0058 0.0089
Schistosoma mansoni hypothetical protein 0.0037 0.0024 0.0053
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Schistosoma mansoni hypothetical protein 0.0108 0.0146 0.0319
Toxoplasma gondii cathepsin CPC1 0.0319 0.0511 0.2121
Entamoeba histolytica cysteine protease, putative 0.0319 0.0511 0.21
Plasmodium vivax unspecified product 0.0319 0.0511 0.21
Schistosoma mansoni hypothetical protein 0.0031 0.0013 0.0029
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.0012 0.0018
Loa Loa (eye worm) glutathione reductase 0.0048 0.0044 0.0084
Trypanosoma brucei Calpain-like protein 2 0.0601 0.0997 0.4021
Schistosoma mansoni brat protein 0.0031 0.0013 0.0029
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Leishmania major calpain, putative,cysteine peptidase, Clan CA, family C2, putative 0.0518 0.0854 0.3409
Schistosoma mansoni neuropeptide receptor 0.0108 0.0146 0.0319
Brugia malayi Cathepsin L-like precursor 0.0965 0.1626 0.3544
Echinococcus multilocularis tachykinin peptides receptor 99D 0.5816 1 1
Onchocerca volvulus 0.0108 0.0146 0.059
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.071 0.1186 0.2561
Echinococcus multilocularis EF hand domain containing family member A2 0.0049 0.0045 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0027 0.0047
Echinococcus granulosus prefoldin subunit 6 0.0103 0.0138 0.0138
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Schistosoma mansoni hypothetical protein 0.0356 0.0575 0.1255
Onchocerca volvulus 0.0048 0.0043 0.0158
Entamoeba histolytica phosphofructokinase, putative 0.0111 0.0151 0.0587
Echinococcus multilocularis rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Brugia malayi Dopamine receptor 0.0108 0.0146 0.0307
Echinococcus multilocularis orexin receptor type 2 0.0108 0.0146 0.0146
Schistosoma mansoni ef hand domain family member A2 0.0048 0.0044 0.0095
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0027 0.0027
Loa Loa (eye worm) hypothetical protein 0.0055 0.0055 0.011
Leishmania major cathepsin L-like protease 0.1454 0.247 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0088 0.1033
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0624 0.1037 0.2254
Schistosoma mansoni peptidylglycine monooxygenase 0.0031 0.0013 0.0029
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0075 0.009 0.009
Toxoplasma gondii calmodulin CAM1 0.0049 0.0045 0.0168
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0965 0.1626 0.6803
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0151 0.0604
Trypanosoma brucei centrin, putative 0.0048 0.0044 0.0151
Brugia malayi G protein-coupled receptor 0.0108 0.0146 0.0307
Onchocerca volvulus 0.0145 0.0211 0.0864
Trypanosoma brucei calpain, putative 0.0262 0.0412 0.1646
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0518 0.0854 0.1833
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0066 0.0075 0.0152
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Trypanosoma brucei caltractin, putative 0.0057 0.0058 0.0209
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Brugia malayi Cathepsin L-like precursor 0.1406 0.2387 0.5207
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0108 0.0146 0.0307
Echinococcus multilocularis cathepsin L cysteine protease 0.1406 0.2387 0.2387
Onchocerca volvulus 0.0108 0.0146 0.059
Plasmodium falciparum plasmepsin X 0.0145 0.0211 0.0839
Schistosoma mansoni cathepsin B (C01 family) 0.0319 0.0511 0.1115
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0108 0.0146 0.0308
Toxoplasma gondii centrin, putative 0.0048 0.0044 0.0161
Loa Loa (eye worm) beta-lactamase 0.0074 0.0088 0.0181
Trypanosoma brucei calpain-like protein, putative 0.0518 0.0854 0.3438
Plasmodium falciparum serine repeat antigen 4 0.0319 0.0511 0.21
Schistosoma mansoni calpain (C02 family) 0.0518 0.0854 0.1864
Leishmania major hypothetical protein, conserved 0.0211 0.0324 0.125
Echinococcus granulosus fmrfamide receptor 0.0108 0.0146 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Leishmania major calpain-like protein, putative,cysteine peptidase, Clan CA, family C2, putative 0.0472 0.0776 0.3091
Toxoplasma gondii PAN/Apple domain-containing protein 0.0042 0.0033 0.0115
Loa Loa (eye worm) hypothetical protein 0.0324 0.052 0.1126
Brugia malayi Serotonin receptor 0.0108 0.0146 0.0307
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0088 0.0088
Plasmodium vivax calpain, putative 0.0518 0.0854 0.3544
Schistosoma mansoni family C2 unassigned peptidase (C02 family) 0.1029 0.1736 0.3791
Brugia malayi hypothetical protein 0.0108 0.0146 0.0307
Giardia lamblia Cathepsin B precursor 0.1048 0.1769 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0713 0.1191 0.4787
Giardia lamblia Hypothetical protein 0.0319 0.0511 0.2839
Trypanosoma cruzi cysteine peptidase, putative 0.1454 0.247 0.5376
Schistosoma mansoni cathepsin D (A01 family) 0.1675 0.2851 0.6225
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0267 0.0421 0.1683
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Onchocerca volvulus 0.0073 0.0086 0.0337
Onchocerca volvulus 0.1406 0.2387 1
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0785 0.1315 0.2843
Echinococcus multilocularis cathepsin L cysteine protease 0.1406 0.2387 0.2387
Schistosoma mansoni dopamine-beta-monooxygenase 0.0624 0.1037 0.2263
Loa Loa (eye worm) hypothetical protein 0.0074 0.0088 0.0181
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0027 0.002
Plasmodium vivax aspartyl proteinase, putative 0.0615 0.1022 0.4252
Trypanosoma cruzi hypothetical protein, conserved 0.0341 0.0549 0.1166
Leishmania major calmodulin, putative 0.0048 0.0044 0.0108
Loa Loa (eye worm) hypothetical protein 0.0624 0.1037 0.2255
Entamoeba histolytica cysteine protease, putative 0.0319 0.0511 0.21
Echinococcus granulosus cathepsin b 0.2676 0.458 0.458
Trichomonas vaginalis phosphofructokinase, putative 0.0111 0.0151 0.0604
Loa Loa (eye worm) hypothetical protein 0.0074 0.0088 0.0181
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0785 0.1315 0.5289
Leishmania major hypothetical protein, conserved 0.0134 0.0192 0.0711
Trichomonas vaginalis calcium binding protein, putative 0.0048 0.0044 0.0153
Trypanosoma cruzi small myristoylated protein 1-2 0.0363 0.0588 0.125
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0108 0.0146 0.0146
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.011 0.0151 0.1847
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Brugia malayi Protein kinase domain containing protein 0.0134 0.0192 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.1406 0.2387 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0027 0.0084
Echinococcus granulosus neuropeptide receptor 0.0478 0.0785 0.0785
Plasmodium falciparum serine repeat antigen 1 0.0319 0.0511 0.21
Giardia lamblia Hypothetical protein 0.0319 0.0511 0.2839
Trypanosoma brucei Domain of unknown function (DUF1935), putative 0.0211 0.0324 0.1288
Leishmania major cathepsin L-like protease 0.1454 0.247 1
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0111 0.0151 0.0294
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0319 0.0511 0.2115
Loa Loa (eye worm) hypothetical protein 0.0154 0.0227 0.0484
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.0179 0.0379
Entamoeba histolytica grainin 2 0.0057 0.0058 0.0194
Echinococcus granulosus tripartite motif containing protein 3 0.0031 0.0013 0.0013
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0033 0.0017 0.0605
Entamoeba histolytica hypothetical protein, conserved 0.0049 0.0045 0.0141
Schistosoma mansoni alpha-1 adrenergic receptor 0.0108 0.0146 0.0319
Plasmodium falciparum thioredoxin reductase 0.0048 0.0044 0.0134
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.1406 0.2387 1
Trichomonas vaginalis hypothetical protein 0.0262 0.0412 0.17
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0108 0.0146 0.0146
Brugia malayi calpain 5 0.0256 0.0402 0.0867
Trypanosoma brucei cytoskeleton-associated protein CAP5.5, putative 0.0472 0.0776 0.3122
Brugia malayi cathepsin Z-like cysteine proteinase 0.0319 0.0511 0.1104
Onchocerca volvulus 0.0066 0.0075 0.0292
Trichomonas vaginalis myosin light chain 1, putative 0.0048 0.0044 0.0153
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0319 0.0511 0.21
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.076 0.1271 0.2749
Loa Loa (eye worm) neuropeptide F receptor 0.0108 0.0146 0.0308
Plasmodium falciparum plasmepsin VI 0.0615 0.1022 0.4252
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Trichomonas vaginalis calmodulin, putative 0.0057 0.0058 0.0213
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0027 0.0083
Toxoplasma gondii prefoldin subunit 6, putative 0.0103 0.0138 0.0555
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0773 0.1295 0.521
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0319 0.0511 0.1105
Plasmodium vivax prefoldin subunit 6, putative 0.0103 0.0138 0.053
Leishmania major hypothetical protein, conserved 0.0211 0.0324 0.125
Trypanosoma brucei calpain-like protein, putative 0.0518 0.0854 0.3438
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0615 0.1022 0.4268
Brugia malayi Copper type II ascorbate-dependent monooxygenase, C-terminal domain containing protein 0.0307 0.049 0.106
Echinococcus multilocularis sex peptide receptor 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Echinococcus granulosus centrin 2 0.0048 0.0044 0.0044
Plasmodium falciparum cysteine proteinase falcipain 2a 0.1406 0.2387 1
Schistosoma mansoni amine GPCR 0.0108 0.0146 0.0319
Brugia malayi hypothetical protein 0.0236 0.0367 0.079
Toxoplasma gondii microneme protein MIC17A 0.0042 0.0033 0.0115
Entamoeba histolytica calcium-binding protein, putative 0.0048 0.0044 0.0134
Brugia malayi EF hand family protein 0.0048 0.0044 0.0084
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0817 0.1371 0.552
Trypanosoma cruzi hypothetical protein, conserved 0.0211 0.0324 0.0672
Loa Loa (eye worm) PAN domain-containing protein 0.0042 0.0033 0.006
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0027 0.0084
Echinococcus granulosus calpain A 0.1078 0.1822 0.1822
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0088 0.0181
Plasmodium falciparum calpain 0.0262 0.0412 0.1684
Echinococcus granulosus EF hand domain containing family member A2 0.0049 0.0045 0.0045
Trichomonas vaginalis calmodulin, putative 0.0048 0.0044 0.0153
Schistosoma mansoni neuropeptide receptor 0.0478 0.0785 0.1715
Leishmania major calmodulin-like protein 0.0048 0.0044 0.0108
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0472 0.0776 0.1662
Schistosoma mansoni calmodulin 0.0048 0.0044 0.0095
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0066 0.0075 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0027 0.0082
Trypanosoma cruzi CAMK/CAMKL family protein kinase, putative 0.0048 0.0044 0.0058
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0319 0.0511 0.1115
Onchocerca volvulus Cathepsin L homolog 0.1406 0.2387 1
Brugia malayi cathepsin B-like cysteine proteinase 0.2676 0.458 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Echinococcus granulosus orexin receptor type 2 0.0108 0.0146 0.0146
Loa Loa (eye worm) melatonin receptor type 1A 0.0108 0.0146 0.0308
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0319 0.0511 0.2839
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0108 0.0146 0.0319
Entamoeba histolytica cysteine proteinase 2 0.076 0.1271 0.5303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0965 0.1626 0.6803
Brugia malayi RNA binding protein 0.0063 0.007 0.014
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0619 0.1028 0.4122
Schistosoma mansoni hypothetical protein 0.0129 0.0182 0.0398
Echinococcus multilocularis tar DNA binding protein 0.0063 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0033 0.0017 0.0036
Echinococcus multilocularis g-protein coupled receptor 0.0108 0.0146 0.0146
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.0012 0.5
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Brugia malayi G-protein coupled receptor 0.0108 0.0146 0.0307
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0123 0.0172 0.2123
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0319 0.0511 0.2115
Schistosoma mansoni cercarial elastase (S01 family) 0.0066 0.0075 0.0164
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Schistosoma mansoni hypothetical protein 0.0108 0.0146 0.0319
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0785 0.1315 0.2843
Onchocerca volvulus 0.0074 0.0088 0.0347
Brugia malayi putative neuropeptide receptor 0.0108 0.0146 0.0307
Trypanosoma brucei cysteine peptidase, Clan CA, family C2, putative 0.0262 0.0412 0.1646
Trichomonas vaginalis calpain, putative 0.0262 0.0412 0.17
Loa Loa (eye worm) hypothetical protein 0.0042 0.0033 0.006
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0817 0.1371 0.2968
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.011 0.0151 0.8698
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.1048 0.1769 0.7142
Brugia malayi Cathepsin L-like precursor 0.1406 0.2387 0.5207
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-5 0.0211 0.0324 0.1288
Schistosoma mansoni hypothetical protein 0.0262 0.0412 0.0899
Trypanosoma cruzi major cysteine proteinase, putative 0.0367 0.0594 0.1263
Loa Loa (eye worm) ctsf protein 0.1406 0.2387 0.5207
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0027 0.13
Echinococcus granulosus dro:myosuppressin receptor 0.0108 0.0146 0.0146
Trypanosoma brucei calpain-like cysteine peptidase, putative 0.0267 0.0421 0.1683
Echinococcus granulosus biogenic amine 5HT receptor 0.0108 0.0146 0.0146
Plasmodium vivax unspecified product 0.076 0.1271 0.5303
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.0511 0.2115
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0308 0.0492 0.104
Echinococcus multilocularis neuropeptide s receptor 0.0108 0.0146 0.0146
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0319 0.0511 0.2839
Echinococcus granulosus peptide allatostatin:somatostatin 0.0108 0.0146 0.0146
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0027 0.0232
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0325 0.0521 0.1139
Onchocerca volvulus 0.0049 0.0045 0.0168
Brugia malayi hypothetical protein 0.0033 0.0018 0.0026
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0108 0.0146 0.0146
Echinococcus multilocularis cathepsin l cysteine peptidase 0.1406 0.2387 0.2387
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0319 0.0511 0.1104
Echinococcus multilocularis muscleblind protein 0.0154 0.0227 0.0227
Plasmodium vivax aspartyl protease, putative 0.0145 0.0211 0.0839
Trypanosoma cruzi small myristoylated protein 1-1 0.0363 0.0588 0.125
Echinococcus granulosus laminin 0.0026 0.0005 0.0005
Brugia malayi Eukaryotic aspartyl protease family protein 0.0145 0.0211 0.045
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0454 0.0744 0.2963
Brugia malayi Dopamine receptor protein 2 0.0108 0.0146 0.0307
Echinococcus multilocularis g protein coupled receptor 0.0108 0.0146 0.0146
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0267 0.0421 0.0885
Schistosoma mansoni calpain-2 (C02 family) 0.0262 0.0412 0.0899
Plasmodium falciparum plasmepsin I 0.0615 0.1022 0.4252
Trypanosoma cruzi cysteine proteinase, putative 0.076 0.1271 0.2749
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0108 0.0146 0.0307
Plasmodium falciparum serine repeat antigen 7 0.0319 0.0511 0.21
Echinococcus multilocularis g protein coupled receptor 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Trichomonas vaginalis conserved hypothetical protein 0.0103 0.0138 0.0547
Echinococcus granulosus sodium channel protein 0.0041 0.003 0.003
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0108 0.0146 0.0146
Trypanosoma brucei META domain/Domain of unknown function (DUF1935), putative 0.0211 0.0324 0.1288
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0308 0.0492 0.104
Loa Loa (eye worm) aspartyl protease 6 0.0145 0.0211 0.045
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0027 0.0241
Brugia malayi hypothetical protein 0.016 0.0236 0.0504
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0111 0.0151 0.8736
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0145 0.0211 0.0461
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Onchocerca volvulus 0.0042 0.0033 0.0115
Echinococcus multilocularis chromobox protein 1 0.0069 0.0079 0.0079
Echinococcus multilocularis neuronal calcium sensor 0.0048 0.0044 0.0044
Leishmania major hypothetical protein, conserved,calpain-like cysteine peptidase, Clan CA, family C2 0.0211 0.0324 0.125
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.1454 0.247 1
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Plasmodium falciparum centrin-1 0.0048 0.0044 0.0134
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0817 0.1371 0.2968
Echinococcus multilocularis neuropeptide receptor A26 0.0108 0.0146 0.0146
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0024 0.0024
Echinococcus multilocularis neurocalcin 0.0048 0.0044 0.0044
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0108 0.0146 0.0146
Brugia malayi B-box zinc finger family protein 0.0031 0.0013 0.0017
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0007 0.0007
Trypanosoma brucei conserved protein 0.022 0.0339 0.1352
Schistosoma mansoni neuronal calcium sensor 0.0048 0.0044 0.0095
Trypanosoma cruzi hypothetical protein, conserved 0.0134 0.0192 0.0382
Trypanosoma cruzi prefoldin subunit, putative 0.0103 0.0138 0.0264
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0108 0.0146 0.0319
Trypanosoma cruzi kinesin, putative 0.0256 0.0402 0.0843
Trichomonas vaginalis calpain, putative 0.0262 0.0412 0.17
Loa Loa (eye worm) hypothetical protein 0.0066 0.0075 0.0152
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0319 0.0511 0.2115
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0108 0.0146 0.0307
Echinococcus multilocularis enteropeptidase 0.0066 0.0075 0.0075
Mycobacterium ulcerans lipase LipD 0.0074 0.0088 0.557
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0056 0.0057 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0319 0.0511 0.2115
Brugia malayi cathepsin Z-like cysteine proteinase 0.0319 0.0511 0.1104
Trypanosoma cruzi cysteine peptidase, Clan CA, family C2, putative 0.0518 0.0854 0.1833
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0032 0.0103
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0454 0.0744 0.2963
Schistosoma mansoni calpain-7 (C02 family) 0.0518 0.0854 0.1864
Loa Loa (eye worm) 6-phosphofructokinase 0.0111 0.0151 0.0319
Loa Loa (eye worm) hypothetical protein 0.0103 0.0138 0.029
Echinococcus multilocularis neuropeptides capa receptor 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0074 0.0088 0.0181
Echinococcus multilocularis somatostatin receptor 0.0108 0.0146 0.0146
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0041 0.003 0.0053
Loa Loa (eye worm) hypothetical protein 0.0026 0.0005 0.0001
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0044 0.0134
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0108 0.0146 0.0319
Echinococcus granulosus neuropeptide Y receptor 0.0108 0.0146 0.0146
Brugia malayi Cathepsin L-like cysteine proteinase 0.0965 0.1626 0.3544
Onchocerca volvulus 0.0042 0.0033 0.0115
Schistosoma mansoni opsin-like receptor 0.0108 0.0146 0.0319
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0061 0.0066 0.0255
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0024 0.0024
Loa Loa (eye worm) hypothetical protein 0.0319 0.0511 0.1105
Brugia malayi calpain family protein 1 0.1029 0.1736 0.3784
Toxoplasma gondii thioredoxin reductase 0.0048 0.0044 0.016
Echinococcus multilocularis EF HAND 1, calcium binding site 0.0048 0.0044 0.0044
Schistosoma mansoni neuropeptide f receptor 76f 0.0108 0.0146 0.0319
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Onchocerca volvulus 0.0319 0.0511 0.2121
Schistosoma mansoni rab 0.0048 0.0044 0.0095
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0319 0.0511 0.21
Entamoeba histolytica cysteine protease, putative 0.0319 0.0511 0.21
Leishmania major hypothetical protein, unknown function 0.0262 0.0412 0.1609
Schistosoma mansoni Mername-AA248 (C02 family) 0.0518 0.0854 0.1864
Entamoeba histolytica cysteine protease, putative 0.076 0.1271 0.5303
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0319 0.0511 0.2839
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0088 0.0339
Echinococcus multilocularis calmodulin 0.0048 0.0044 0.0044
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0817 0.1371 0.552
Trypanosoma brucei Small kinetoplastid calpain-related protein 1-4 0.0211 0.0324 0.1288
Onchocerca volvulus 0.0074 0.0088 0.0347
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0108 0.0146 0.0146
Trypanosoma cruzi calpain-like cysteine peptidase, putative 0.0785 0.1315 0.2843
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0027 0.5
Echinococcus multilocularis serotonin receptor 0.0108 0.0146 0.0146
Brugia malayi PAN domain containing protein 0.0042 0.0033 0.006
Echinococcus multilocularis geminin 0.0356 0.0575 0.0575
Brugia malayi fibroinase precursor 0.0319 0.0511 0.1104
Giardia lamblia Cathepsin L precursor 0.0319 0.0511 0.2839
Leishmania major hypothetical protein, conserved 0.0074 0.0088 0.0289
Toxoplasma gondii subtilisin SUB12 0.0042 0.0033 0.0115
Trichomonas vaginalis calcineurin B subunit, putative 0.0048 0.0044 0.0153
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Brugia malayi Calmodulin-like protein 0.0048 0.0044 0.0084
Echinococcus granulosus rhodopsin orphan GPCR 0.0108 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.0108 0.0146 0.0308
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0325 0.0521 0.1139
Trichomonas vaginalis calmodulin, putative 0.0049 0.0045 0.016
Giardia lamblia Cathepsin B precursor 0.1048 0.1769 1
Leishmania major calpain-like cysteine peptidase, putative,cysteine peptidase, Clan CA, family C2, putative 0.0601 0.0997 0.3994
Loa Loa (eye worm) cysteine protease 0.1406 0.2387 0.5207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0319 0.0511 0.2115
Loa Loa (eye worm) hypothetical protein 0.1174 0.1987 0.4332
Leishmania major cathepsin L-like protease 0.1406 0.2387 0.9661
Brugia malayi Pepsin A precursor 0.0145 0.0211 0.045

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.6 nM Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. ChEMBL. 10978189
IC50 (binding) = 6.6 nM Antisecretory potency, affinity for intestinal PYY of rat jejunum by using short circuit current (SCC) method. ChEMBL. 10978189
IC50 (binding) = 7.08 nM Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line ChEMBL. 10978189
IC50 (binding) = 7.08 nM Affinity against Neuropeptide Y receptor Y2 in SK-N-BE2 cell line ChEMBL. 10978189
IC50 (binding) = 88.3 nM Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line ChEMBL. 10978189
IC50 (binding) = 88.3 nM Affinity against Neuropeptide Y receptor Y1 in SK-N-MC cell line ChEMBL. 10978189

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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