Detailed information for compound 406991

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1487.7 | Formula: C64H98N18O19S2
  • H donors: 21 H acceptors: 19 LogP: -11.36 Rotable bonds: 27
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@H]1NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](CCC(=O)N)NC(=O)[C@@H](C)NC(=O)[C@@H](CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](NC(=O)[C@@H](NC1=O)CCC(=O)O)[C@H](O)C)Cc1ccccc1)C(=O)O)N
  • InChi: 1S/C64H98N18O19S2/c1-34-52(89)73-42(21-24-48(68)84)58(95)79-45(30-36-14-5-3-6-15-36)60(97)76-41(20-13-29-71-64(69)70)56(93)74-39(18-9-11-27-65)54(91)77-43(22-25-49(85)86)57(94)75-40(19-10-12-28-66)55(92)78-44(23-26-50(87)88)59(96)82-51(35(2)83)62(99)80-46(31-37-16-7-4-8-17-37)61(98)81-47(63(100)101)33-103-102-32-38(67)53(90)72-34/h3-8,14-17,34-35,38-47,51,83H,9-13,18-33,65-67H2,1-2H3,(H2,68,84)(H,72,90)(H,73,89)(H,74,93)(H,75,94)(H,76,97)(H,77,91)(H,78,92)(H,79,95)(H,80,99)(H,81,98)(H,82,96)(H,85,86)(H,87,88)(H,100,101)(H4,69,70,71)/t34-,35-,38-,39-,40-,41+,42+,43+,44+,45-,46+,47+,51-/m1/s1
  • InChiKey: IYWWTDYPQATACO-BDUUBTEFSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0015 0.0031
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0064 0.0135
Echinococcus granulosus neurogenic locus protein delta 0.0043 0.0305 0.0437
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0476 0.212
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.1422 0.2984
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0238 0.034
Onchocerca volvulus 0.0411 0.4076 1
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0238 0.0498
Schistosoma mansoni notch 0.0043 0.0305 0.0305
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Echinococcus granulosus muscleblind protein 0.0151 0.1409 0.2014
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0306 0.1015
Echinococcus multilocularis protein jagged 1 0.0043 0.0305 0.0437
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0019 0.0064 0.0135
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0025 0.0024
Schistosoma mansoni microtubule-associated protein tau 0.0696 0.6997 0.6997
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Echinococcus multilocularis slit 2 protein 0.0043 0.0305 0.0437
Schistosoma mansoni sodium/chloride dependent transporter 0.0091 0.0803 0.0802
Brugia malayi hypothetical protein 0.0025 0.0126 0.0264
Schistosoma mansoni notch 0.0043 0.0305 0.0305
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0135
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Mycobacterium ulcerans beta-lactamase 0.0036 0.0238 4.0268e-17
Onchocerca volvulus Chorion peroxidase homolog 0.0411 0.4076 1
Schistosoma mansoni septate junction protein 0.0043 0.0305 0.0305
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0238 0.0777
Brugia malayi notch-like transmembrane receptor 0.0043 0.0305 0.0641
Loa Loa (eye worm) doublecortin family protein 0.004 0.0275 0.0577
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0083 0.0717 0.2393
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0064 0.0092
Schistosoma mansoni peroxidasin 0.0411 0.4076 0.4075
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0051 0.0126
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.0043 0.0305 0.0305
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0064
Brugia malayi hypothetical protein 0.0165 0.1552 0.3258
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Trichomonas vaginalis set domain proteins, putative 0.024 0.232 0.8029
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0571 0.0571
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0306 0.0437
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0083 0.0717 0.2393
Brugia malayi acetyltransferase, GNAT family protein 0.0146 0.1363 0.2862
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0083 0.0717 0.4348
Schistosoma mansoni hypothetical protein 0.0036 0.0237 0.0237
Schistosoma mansoni rab6-interacting 0.004 0.0275 0.0274
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0924 0.0924
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Onchocerca volvulus Neurogenic locus notch homolog 0.0043 0.0305 0.0693
Brugia malayi Animal haem peroxidase family protein 0.0411 0.4076 0.8556
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.0305 0.0437
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0015 0.0019 0.0017
Schistosoma mansoni polycystin 1-related 0.004 0.0275 0.0274
Loa Loa (eye worm) Notch2 0.0043 0.0305 0.0641
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0306 0.1338
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0234 0.2259 0.4743
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0144 0.0303
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0083 0.0717 0.4348
Echinococcus granulosus notch 0.0043 0.0305 0.0437
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0103 0.0924 0.1321
Onchocerca volvulus 0.0043 0.0305 0.0693
Onchocerca volvulus 0.0091 0.0803 0.1921
Onchocerca volvulus Slit protein homolog 0.0043 0.0305 0.0693
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0083 0.0717 0.2393
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0275 0.0393
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0163 0.0232
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0016 0.0025 0.0035
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0083 0.0717 0.4348
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0174
Toxoplasma gondii MAPEG family protein 0.0227 0.2188 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0162 0.0341
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0238 0.1636
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0548 0.6181
Brugia malayi follicle stimulating hormone receptor 0.0234 0.2259 0.4743
Loa Loa (eye worm) CHromoDomain protein family member 0.0013 0 0.0001
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0016 0.0025 0.0035
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0238 4.0268e-17
Echinococcus granulosus Regulator of G protein signaling 20 0.0019 0.0064 0.0092
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0144 0.0302
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0499
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0083 0.0717 0.2393
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0016 0.0025 0.0035
Loa Loa (eye worm) RGS-3 protein 0.0019 0.0064 0.0135
Brugia malayi Cytochrome P450 family protein 0.0083 0.0717 0.1506
Onchocerca volvulus 0.0036 0.0238 0.0526
Echinococcus granulosus histone acetyltransferase KAT2B 0.0142 0.1321 0.1888
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0083 0.0717 0.4348
Onchocerca volvulus 0.0029 0.0162 0.034
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0144 0.0303
Brugia malayi GCC2 and GCC3 family protein 0.0043 0.0305 0.0641
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0499
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1341 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.2886 1
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0025 0.0024
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0238 4.0268e-17
Loa Loa (eye worm) CYP4Cod1 0.0092 0.0808 0.1697
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0064 0.0135
Schistosoma mansoni lamin 0.0027 0.0144 0.0144
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0305 0.0641
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0025 0.0035
Loa Loa (eye worm) PXA domain-containing protein 0.0019 0.0064 0.0135
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0083 0.0717 0.2393
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.018 0.018
Loa Loa (eye worm) cytochrome P450 family protein 0.0122 0.1113 0.2336
Entamoeba histolytica hypothetical protein 0.0036 0.0237 0.0613
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0025 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Echinococcus multilocularis peroxidasin 0.0411 0.4076 0.5825
Brugia malayi Doublecortin family protein 0.004 0.0275 0.0576
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0083 0.0717 0.4348
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0083 0.0717 0.8667
Echinococcus multilocularis musashi 0.0027 0.0144 0.0206
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0051 0.0126
Echinococcus granulosus survival motor neuron protein 1 0.0478 0.4763 0.6807
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0083 0.0717 0.4348
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0083 0.0717 0.2393
Loa Loa (eye worm) cytochrome P450 family protein 0.0092 0.0808 0.1697
Loa Loa (eye worm) hypothetical protein 0.0031 0.018 0.0379
Echinococcus multilocularis 0.0083 0.0717 0.1025
Entamoeba histolytica hypothetical protein 0.0036 0.0237 0.0613
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0025 0.0035
Brugia malayi hypothetical protein 0.0016 0.0034 0.007
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Schistosoma mansoni sodium-dependent amino acid transporter 0.0016 0.0025 0.0024
Onchocerca volvulus 0.0027 0.0144 0.0295
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0025 0.0024
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0083 0.0717 0.4348
Schistosoma mansoni notch 0.0043 0.0305 0.0305
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0794 0.0794
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0083 0.0717 0.2393
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0103 0.0924 0.1321
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0499
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.2886 1
Brugia malayi Pre-SET motif family protein 0.0211 0.2023 0.4247
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0238 0.0237
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.0237 0.0339
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Schistosoma mansoni rab6-interacting 0.004 0.0275 0.0274
Mycobacterium leprae putative cytochrome p450 0.0083 0.0717 0.4348
Schistosoma mansoni notch 0.0043 0.0305 0.0305
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0571 0.1939
Echinococcus multilocularis geminin 0.0171 0.1617 0.2311
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0064 0.0064
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0275 1
Schistosoma mansoni hypothetical protein 0.0098 0.0864 0.0864
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0275 0.0393
Brugia malayi hypoxia-induced factor 1 0.0152 0.1422 0.2984
Brugia malayi hypothetical protein 0.0478 0.4763 1
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0015 0.0031
Echinococcus granulosus delta-like protein 1 0.0043 0.0305 0.0437
Brugia malayi CXXC zinc finger family protein 0.0029 0.0162 0.034
Brugia malayi hypothetical protein 0.0036 0.0237 0.0498
Trichomonas vaginalis esterase, putative 0.0036 0.0238 0.0777
Echinococcus granulosus Ankyrin repeat domain containing protein 0.0091 0.0794 0.1135
Echinococcus multilocularis survival motor neuron protein 1 0.0478 0.4763 0.6807
Schistosoma mansoni hypothetical protein 0.0171 0.1617 0.1617
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0083 0.0717 0.4348
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0025 0.0024
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0025 0.0035
Mycobacterium ulcerans lipase LipD 0.0036 0.0238 4.0268e-17
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0064 0.0135
Loa Loa (eye worm) animal heme peroxidase 0.0411 0.4076 0.8556
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0064 0.0092
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0083 0.0717 0.2393
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0092 0.0808 0.5172
Toxoplasma gondii hypothetical protein 0.0016 0.0025 0.0043
Entamoeba histolytica hypothetical protein 0.0036 0.0237 0.0613
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Onchocerca volvulus 0.0042 0.0298 0.0676
Echinococcus granulosus single minded 2 0.0036 0.0238 0.034
Loa Loa (eye worm) hypothetical protein 0.0151 0.1409 0.2959
Echinococcus multilocularis RUN 0.004 0.0275 0.0393
Echinococcus granulosus protein jagged 2 0.0043 0.0305 0.0437
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0091 0.0803 0.0802
Echinococcus granulosus microsomal glutathione S transferase 3 0.0227 0.2188 0.3127
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Schistosoma mansoni hypothetical protein 0.0171 0.1617 0.1617
Echinococcus granulosus slit 2 protein 0.0043 0.0305 0.0437
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.2243 1
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0083 0.0717 0.4348
Brugia malayi cytochrome P450 0.0083 0.0717 0.1506
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0174
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.018 0.076
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0238 0.0237
Echinococcus multilocularis sodium and chloride dependent glycine 0.0016 0.0025 0.0035
Trypanosoma cruzi cytochrome P450, putative 0.0092 0.0808 1
Onchocerca volvulus Putative cubilin 0.0043 0.0305 0.0693
Brugia malayi beta-lactamase family protein 0.0036 0.0238 0.0498
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0126 0.3604
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Loa Loa (eye worm) cytochrome P450 family protein 0.0092 0.0808 0.1697
Brugia malayi PXA domain containing protein 0.0019 0.0064 0.0135
Onchocerca volvulus 0.0027 0.0144 0.0295
Echinococcus granulosus geminin 0.0171 0.1617 0.2311
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0238 0.0777
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1409 0.2014
Schistosoma mansoni lamin 0.0027 0.0144 0.0144
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.0305 0.0437
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.0043 0.0305 0.0641
Brugia malayi Cadherin domain containing protein 0.0043 0.0305 0.0641
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0083 0.0717 0.4348
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0083 0.0717 0.8667
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0067 0.0548 0.1149
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0924 0.0924
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0548 0.6181
Brugia malayi beta-lactamase 0.0036 0.0238 0.0498
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0067 0.0548 0.0547
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0238 0.0498
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0067 0.0548 0.1713
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0083 0.0717 0.4348
Onchocerca volvulus 0.004 0.0275 0.0617
Onchocerca volvulus 0.0411 0.4076 1
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0306 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0238 0.0499
Toxoplasma gondii ABC1 family protein 0.0036 0.0238 0.1023
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Echinococcus granulosus sodium and chloride dependent glycine 0.0016 0.0025 0.0035
Echinococcus multilocularis serotonin transporter 0.0091 0.0803 0.1147
Schistosoma mansoni loxhd1 0.004 0.0275 0.0274
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Onchocerca volvulus 0.0102 0.0912 0.2191
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0083 0.0717 0.8667
Brugia malayi regulator of G-protein signaling rgs-7 0.0019 0.0064 0.0135
Onchocerca volvulus 0.0043 0.0305 0.0693
Brugia malayi Regulator of G protein signaling domain containing protein 0.0019 0.0064 0.0135
Leishmania major hypothetical protein, conserved 0.0036 0.0238 0.1636
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0019 0.0064 0.0092
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0083 0.0717 0.4348
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Echinococcus granulosus protein jagged 1 0.0043 0.0305 0.0437
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0064 0.0092
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0135
Schistosoma mansoni microsomal glutathione s-transferase 0.0227 0.2188 0.2188
Loa Loa (eye worm) solute carrier family 6 member 4 0.0091 0.0803 0.1685
Brugia malayi Cadherin domain containing protein 0.0043 0.0305 0.0641
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0275 0.0393
Schistosoma mansoni multiple ankyrin repeats single kh domain protein 0.0091 0.0794 0.0794
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0174
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.2886 1
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0083 0.0717 0.4348
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0083 0.0717 0.2393
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1341 0.5503
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0238 0.1636
Echinococcus granulosus neural cadherin 0.0043 0.0305 0.0437
Schistosoma mansoni cpg binding protein 0.0031 0.0179 0.0179
Brugia malayi PAS domain containing protein 0.0049 0.0368 0.0773
Echinococcus granulosus cytochrome P450 2K1 0.0083 0.0717 0.1025
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0027 0.0139 0.0292
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi intermediate filament protein 0.0027 0.0144 0.0302
Echinococcus granulosus dnaJ subfamily B 0.0413 0.4093 0.5849
Echinococcus multilocularis regulator of G protein signaling 0.0019 0.0064 0.0092
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0064 0.0064
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.018 0.018
Brugia malayi Animal haem peroxidase family protein 0.0411 0.4076 0.8556
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0016 0.0025 0.5
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0067 0.0548 0.0783
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0083 0.0717 0.8667
Brugia malayi beta-lactamase family protein 0.0036 0.0238 0.0498
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0083 0.0717 0.4348
Schistosoma mansoni cpg binding protein 0.0031 0.0179 0.0179
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0051 0.0126
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0064 0.0064
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 0.4055
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0083 0.0717 0.2393
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Echinococcus granulosus expressed protein 0.0378 0.3739 0.5343
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.0506 0.0506
Plasmodium vivax SET domain protein, putative 0.0031 0.018 0.554
Echinococcus granulosus intermediate filament protein 0.0027 0.0144 0.0206
Echinococcus multilocularis neural cadherin 0.0043 0.0305 0.0437
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0083 0.0717 0.4348
Onchocerca volvulus 0.0411 0.4076 1
Echinococcus multilocularis lamin 0.0027 0.0144 0.0206
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Schistosoma mansoni intermediate filament proteins 0.0027 0.0144 0.0144
Echinococcus multilocularis neurogenic locus notch protein 4 0.0043 0.0305 0.0437
Brugia malayi hypothetical protein 0.004 0.0275 0.0576
Mycobacterium leprae Conserved hypothetical protein 0.0083 0.0717 0.4348
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Echinococcus granulosus serotonin transporter 0.0091 0.0803 0.1147
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0016 0.0025 0.0024
Echinococcus granulosus fibropellin Ia 0.0043 0.0305 0.0437
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0146 0.1363 0.1363
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Onchocerca volvulus 0.0043 0.0305 0.0693
Brugia malayi hypothetical protein 0.0102 0.0912 0.1915
Schistosoma mansoni cell polarity protein 0.0043 0.0305 0.0305
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0064 0.0092
Brugia malayi Animal haem peroxidase family protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0016 0.0025 0.0035
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0368 0.0368
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0025 0.0024
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0238 0.034
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Loa Loa (eye worm) hypothetical protein 0.0091 0.0803 0.1685
Loa Loa (eye worm) hypothetical protein 0.0478 0.4763 1
Brugia malayi SET domain containing protein 0.0013 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0135
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi Cytochrome P450 family protein 0.0092 0.0808 0.1696
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.018 0.0258
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0015 0.0015
Schistosoma mansoni slit 0.0043 0.0305 0.0305
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0043
Brugia malayi M-phase phosphoprotein, mpp8 0.0102 0.0912 0.1915
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Loa Loa (eye worm) hypothetical protein 0.0102 0.0912 0.1915
Schistosoma mansoni hypothetical protein 0.0043 0.0305 0.0305
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0305 0.0641
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Trypanosoma brucei cytochrome P450, putative 0.0092 0.0808 1
Loa Loa (eye worm) serotonin transporter b 0.0091 0.0803 0.1685
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0064 0.0092
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0924 0.0924
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi Peroxidasin 0.0411 0.4076 0.8556
Echinococcus multilocularis transcription factor Dp 1 0.0039 0.026 0.0372
Brugia malayi hypothetical protein 0.0016 0.0025 0.0051
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0275 0.0577
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0135
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.018 0.0258
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0238 0.0777
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0064
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0051
Schistosoma mansoni peroxidasin 0.0411 0.4076 0.4075
Schistosoma mansoni hypothetical protein 0.0413 0.4093 0.4093
Brugia malayi Cytochrome P450 family protein 0.0122 0.1113 0.2335
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0083 0.0717 0.2393
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Onchocerca volvulus Neurogenic locus notch protein homolog 0.0043 0.0305 0.0693
Echinococcus multilocularis muscleblind protein 0.0151 0.1409 0.2014
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0083 0.0717 0.2393
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0083 0.0717 0.2393
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0269 0.9784
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0864 0.1814
Schistosoma mansoni laminin gamma-3 chain 0.0043 0.0305 0.0305
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0083 0.0717 0.8667
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0275 0.0393
Schistosoma mansoni serine/threonine protein kinase 0.0019 0.0064 0.0064
Echinococcus granulosus peroxidasin 0.0411 0.4076 0.5825
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0064 0.0092
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0016 0.0025 0.0024
Echinococcus granulosus transcription factor Dp 1 0.0039 0.026 0.0372
Schistosoma mansoni survival motor neuron protein 0.0098 0.0864 0.0864
Schistosoma mansoni notch 0.0043 0.0305 0.0305
Echinococcus granulosus cpg binding protein 0.0031 0.0179 0.0256
Echinococcus multilocularis Regulator of G protein signaling 20 0.0019 0.0064 0.0092
Schistosoma mansoni cytochrome P450 0.0083 0.0717 0.0717
Echinococcus granulosus beta-adrenergic receptor kinase 0.0019 0.0064 0.0092
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0064 0.0064
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0238 0.7569
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0083 0.0717 0.2393
Leishmania major cytochrome p450-like protein 0.0092 0.0808 1
Schistosoma mansoni axis inhibition protein axin 0.0019 0.0064 0.0064
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0275 0.8888
Loa Loa (eye worm) hypothetical protein 0.0025 0.0126 0.0265
Brugia malayi hypothetical protein 0.004 0.0275 0.0576
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0174
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0016 0.0025 0.0024
Onchocerca volvulus 0.0036 0.0238 0.0526
Echinococcus multilocularis regulator of G protein signaling 3 0.0019 0.0064 0.0092
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0019 0.0064 0.0064
Toxoplasma gondii hypothetical protein 0.0016 0.0025 0.0043
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.018 0.0258
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0135
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0019 0.0064 0.0135
Schistosoma mansoni lipoxygenase 0.0103 0.0926 0.0925
Echinococcus granulosus neurogenic locus notch protein 4 0.0043 0.0305 0.0437
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.0237 0.0237
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0083 0.0717 0.4348
Toxoplasma gondii melibiase subfamily protein 0.0103 0.0924 0.4183
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.004 0.0275 0.0577
Brugia malayi Muscleblind-like protein 0.0151 0.1409 0.2958
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0083 0.0717 0.4348
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2023 0.4247
Loa Loa (eye worm) acetyltransferase 0.0146 0.1363 0.2862
Schistosoma mansoni lipoxygenase 0.0175 0.1662 0.1662
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Trypanosoma cruzi cytochrome P450, putative 0.0092 0.0808 1
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0016 0.0025 0.0051
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0052
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0064 0.0064
Onchocerca volvulus Peroxidasin homolog 0.0411 0.4076 1
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0083 0.0717 0.2393
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0083 0.0717 0.4348
Echinococcus multilocularis microtubule associated protein 2 0.0696 0.6997 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0016 0.0025 0.0035
Onchocerca volvulus 0.0043 0.0305 0.0693
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0083 0.0717 0.2393
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0067 0.0548 0.0783
Loa Loa (eye worm) animal heme peroxidase 0.0411 0.4076 0.8556
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0019 0.0017
Brugia malayi Delta serrate ligand family protein 0.0043 0.0305 0.0641
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0571 0.0571
Onchocerca volvulus Peroxidase homolog 0.0411 0.4076 1
Echinococcus granulosus lamin dm0 0.0027 0.0144 0.0206
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0306 0.1015
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Loa Loa (eye worm) hypothetical protein 0.0102 0.0912 0.1915
Echinococcus granulosus regulator of G protein signaling 3 0.0019 0.0064 0.0092
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0067 0.0548 0.6181
Schistosoma mansoni hypothetical protein 0.004 0.0275 0.0274
Loa Loa (eye worm) animal heme peroxidase 0.0411 0.4076 0.8556
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0499
Toxoplasma gondii EGF family domain-containing protein 0.0043 0.0305 0.1335
Echinococcus multilocularis fibropellin Ia 0.0043 0.0305 0.0437
Echinococcus granulosus neurogenic locus notch protein 0.0043 0.0305 0.0437
Onchocerca volvulus 0.004 0.0275 0.0617
Loa Loa (eye worm) hypothetical protein 0.0091 0.0803 0.1685
Echinococcus multilocularis lamin dm0 0.0027 0.0144 0.0206
Loa Loa (eye worm) hypothetical protein 0.0019 0.0064 0.0135
Loa Loa (eye worm) notch protein 0.0043 0.0305 0.0641
Leishmania major cytochrome p450-like protein 0.0083 0.0717 0.8667
Echinococcus granulosus microtubule associated protein 2 0.0696 0.6997 1
Echinococcus multilocularis protein jagged 2 0.0043 0.0305 0.0437
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.0305 0.0437
Echinococcus multilocularis protein jagged 1 0.0043 0.0305 0.0437
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0027 0.0144 0.0303
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0067 0.0548 0.6181
Brugia malayi PXA domain containing protein 0.0019 0.0064 0.0135
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi Calcium binding EGF domain containing protein 0.0043 0.0305 0.0641
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0051 0.0126
Onchocerca volvulus 0.0043 0.0305 0.0693
Brugia malayi Blistered cuticle protein 3 0.0411 0.4076 0.8556
Giardia lamblia High cysteine protein 0.0043 0.0305 0.0138
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0126 0.4055
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0175 0.1662 0.2376
Loa Loa (eye worm) animal heme peroxidase 0.0411 0.4076 0.8556
Onchocerca volvulus 0.0098 0.0864 0.2073
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0126 0.0509
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0083 0.0717 0.2393
Loa Loa (eye worm) hypothetical protein 0.0091 0.0803 0.1685
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0043
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.2886 1
Leishmania major cytochrome p450-like protein 0.0083 0.0717 0.8667
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0275 0.0393
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0275 0.0393
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) norepinephrine transporter 0.0091 0.0803 0.1685
Onchocerca volvulus 0.0036 0.0238 0.0526
Echinococcus multilocularis neurogenic locus notch protein 0.0043 0.0305 0.0437
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0052
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0051
Echinococcus granulosus protein jagged 1 0.0043 0.0305 0.0437
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0019 0.0064 0.0092
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0103 0.0924 0.0924
Brugia malayi A-kinase anchor protein 10, precursor 0.0019 0.0064 0.0135
Brugia malayi hypothetical protein 0.0019 0.0064 0.0135
Onchocerca volvulus 0.0102 0.0912 0.2191
Loa Loa (eye worm) hypothetical protein 0.0151 0.1409 0.2959
Echinococcus multilocularis dnaJ subfamily B 0.0413 0.4093 0.5849
Brugia malayi Animal haem peroxidase family protein 0.0411 0.4076 0.8556
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0083 0.0717 0.2393
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0499
Brugia malayi Cytochrome P450 family protein 0.0092 0.0808 0.1696
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0165 0.1552 0.3259
Mycobacterium ulcerans hypothetical protein 0.0036 0.0238 4.0268e-17
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0016 0.0025 0.0035
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0238 0.034
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0051 0.0126
Brugia malayi hypothetical protein 0.0019 0.0064 0.0135
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0238 0.0777
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0269 0.0726
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0064 0.0092
Schistosoma mansoni hypothetical protein 0.0083 0.0717 0.0717
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0238 0.1636
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Onchocerca volvulus 0.0036 0.0238 0.0526
Echinococcus granulosus protein jagged 2 0.0043 0.0305 0.0437
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.0237 0.0339
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Brugia malayi Melibiase family protein 0.0069 0.0571 0.1199
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0051 0.0126
Loa Loa (eye worm) hypothetical protein 0.0016 0.0025 0.0052
Loa Loa (eye worm) blistered cuticle protein 3 0.0411 0.4076 0.8556
Echinococcus multilocularis cpg binding protein 0.0031 0.0179 0.0256
Loa Loa (eye worm) cytochrome P450 0.0083 0.0717 0.1506
Echinococcus multilocularis neurogenic locus protein delta 0.0043 0.0305 0.0437
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0083 0.0717 0.4348
Onchocerca volvulus Peroxidasin homolog 0.0411 0.4076 1
Schistosoma mansoni cpg binding protein 0.0029 0.0162 0.0162
Echinococcus multilocularis fat cadherin tumor suppressor 0.0043 0.0305 0.0437
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0091 0.0803 0.1684
Brugia malayi Animal haem peroxidase family protein 0.0411 0.4076 0.8556
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0083 0.0717 0.2393
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0019 0.0064 0.0135
Onchocerca volvulus 0.024 0.232 0.5666
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.0298 0.0298
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0018 0.0051 0.0126
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0238 0.0777
Echinococcus granulosus lamin 0.0027 0.0144 0.0206
Schistosoma mansoni notch 0.0043 0.0305 0.0305
Loa Loa (eye worm) beta-lactamase 0.0036 0.0238 0.0499
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0019 0.0064 0.0174
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0175 0.1662 0.2376
Brugia malayi hypothetical protein 0.0411 0.4076 0.8556
Echinococcus multilocularis Ankyrin repeat domain containing protein 0.0091 0.0794 0.1135
Toxoplasma gondii cytochrome p450 superfamily protein 0.0083 0.0717 0.3231
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0067 0.0548 0.115
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0174
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0083 0.0717 0.2393
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0227 0.2188 0.3127
Echinococcus granulosus axis inhibition protein axin 0.0019 0.0064 0.0092
Echinococcus granulosus RUN 0.004 0.0275 0.0393
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0103 0.0924 0.1321
Loa Loa (eye worm) hypothetical protein 0.0069 0.0571 0.12
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi Pre-SET motif family protein 0.0031 0.018 0.0378
Trichomonas vaginalis conserved hypothetical protein 0.0019 0.0064 0.0174
Schistosoma mansoni sodium/chloride dependent transporter 0.0016 0.0025 0.0024
Onchocerca volvulus Dual oxidase homolog 0.0411 0.4076 1
Onchocerca volvulus Peroxidase homolog 0.0411 0.4076 1
Echinococcus multilocularis notch 0.0043 0.0305 0.0437
Loa Loa (eye worm) hypothetical protein 0.0043 0.0305 0.0641
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Entamoeba histolytica hypothetical protein 0.0036 0.0237 0.0613
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0306 0.1338
Schistosoma mansoni single-minded 0.0049 0.0368 0.0368
Loa Loa (eye worm) hypothetical protein 0.0036 0.0238 0.0499
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.2886 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0016 0.0025 0.0051
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0083 0.0717 0.4348
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0018 0.0051 0.0126
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0146 0.1363 0.1948
Echinococcus multilocularis axis inhibition protein axin 0.0019 0.0064 0.0092
Brugia malayi EGF-like domain containing protein 0.0043 0.0305 0.0641
Echinococcus multilocularis expressed protein 0.0378 0.3739 0.5343
Loa Loa (eye worm) hypothetical protein 0.0411 0.4076 0.8556
Echinococcus multilocularis beta adrenergic receptor kinase 0.0019 0.0064 0.0092
Brugia malayi Muscle positioning protein 4 0.0043 0.0305 0.0641

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 35 % Percent inhibition of E-rossette formation in sheep red blood cells at 200 uM on preincubation with T-cells ChEMBL. 16190751
Inhibition (functional) = 35 % Percent inhibition of E-rossette formation in sheep red blood cells at 200 uM on preincubation with T-cells ChEMBL. 16190751
Inhibition (functional) = 50 % Percent inhibition of CD58 and CD2 interaction in caco-2 and Jurkat cell adhesion assay at 90 uM ChEMBL. 16190751

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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