Detailed information for compound 423760

Basic information

Technical information
  • TDR Targets ID: 423760
  • Name: 2-[2-[4-(trifluoromethyl)phenyl]pyridin-4-yl] -1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-on e
  • MW: 357.329 | Formula: C19H14F3N3O
  • H donors: 2 H acceptors: 2 LogP: 3.2 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1NCCc2c1cc([nH]2)c1ccnc(c1)c1ccc(cc1)C(F)(F)F
  • InChi: 1S/C19H14F3N3O/c20-19(21,22)13-3-1-11(2-4-13)16-9-12(5-7-23-16)17-10-14-15(25-17)6-8-24-18(14)26/h1-5,7,9-10,25H,6,8H2,(H,24,26)
  • InChiKey: IQFURFKRHVLOTG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-[2-[4-(trifluoromethyl)phenyl]-4-pyridyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus granulosus MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Schistosoma japonicum ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative Get druggable targets OG5_131483 All targets in OG5_131483
Echinococcus multilocularis MAP kinase activated protein kinase 2 Get druggable targets OG5_131483 All targets in OG5_131483
Brugia malayi map kinase activated protein kinase protein 2 Get druggable targets OG5_131483 All targets in OG5_131483
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase-activated protein kinase 2 370 aa 303 aa 26.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0147 0.0294
Loa Loa (eye worm) tubulin alpha-2 chain 0.0604 0.3658 0.7401
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.0025 0.0052
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0167 0.0956 0.1924
Leishmania major cathepsin L-like protease 0.0017 0.0028 0.0056
Brugia malayi Cathepsin L-like precursor 0.0017 0.0028 0.0056
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0034 0.0046
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0025 0.0076 0.0102
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0187 0.0375
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.0223 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1523 0.3078
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.0223 0.0221
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0161 0.0297
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Echinococcus granulosus roundabout 2 0.003 0.0109 0.0217
Entamoeba histolytica tubulin family protein 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Trichomonas vaginalis esterase, putative 0.0071 0.0365 0.0734
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0184 0.036
Echinococcus granulosus Tubulin beta 2C chain 0.0811 0.4943 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0146
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.0226 0.0453
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0417 0.0844
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Loa Loa (eye worm) tubulin alpha-3 chain 0.0357 0.2134 0.4318
Echinococcus multilocularis L aminoadipate semialdehyde 0.0167 0.0956 0.0955
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0215 0.0431
Echinococcus granulosus peroxisome assembly protein 26 0.0604 0.3658 0.74
Plasmodium falciparum alpha tubulin 2 0.0604 0.3658 0.7387
Toxoplasma gondii transporter, major facilitator family protein 0.0056 0.0271 0.0521
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0109 0.0596 0.2097
Brugia malayi hypothetical protein 0.0042 0.0184 0.0373
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0025 0.0076 0.0132
Brugia malayi Immunoglobulin I-set domain containing protein 0.0024 0.0072 0.0145
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.0223 0.0446
Echinococcus multilocularis neuropeptide receptor A26 0.0475 0.286 0.2858
Echinococcus multilocularis tubulin alpha chain 0.0604 0.3658 0.3657
Loa Loa (eye worm) hypothetical protein 0.0075 0.0389 0.0786
Echinococcus granulosus NCK adaptor protein 0.0013 0.0007 0.0009
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.0796 0.1607
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0156 0.0154
Schistosoma mansoni RAR-like nuclear receptor 0.008 0.0417 0.0832
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Loa Loa (eye worm) hypothetical protein 0.0033 0.0128 0.0259
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0048 0.0218 0.0708
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0215 0.0435
Echinococcus granulosus Tubulin beta 2C chain 0.0811 0.4943 1
Leishmania major eukaryotic initiation factor 4a, putative 0.0025 0.0076 0.0153
Schistosoma mansoni hypothetical protein 0.0034 0.0132 0.0254
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0047 0.0214 0.1768
Loa Loa (eye worm) hypothetical protein 0.0034 0.0134 0.0272
Echinococcus multilocularis tumor protein p63 0.034 0.2029 0.2028
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0156 0.0303
Plasmodium vivax vivapain-2 0.0017 0.0028 0.0034
Loa Loa (eye worm) hypothetical protein 0.0104 0.0566 0.1146
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0002 0.0004
Schistosoma mansoni organic anion transporter 0.0056 0.0271 0.0535
Loa Loa (eye worm) tubulin alpha 2 0.0396 0.2372 0.4798
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0039 0.0164 0.0281
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0154 0.0152
Schistosoma mansoni tyrosine kinase 0.0165 0.0946 0.1903
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.0271 0.0548
Plasmodium vivax ataxin-2 like protein, putative 0.0075 0.0389 0.0766
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0156 0.0303
Brugia malayi hypothetical protein 0.0225 0.1316 0.2662
Echinococcus granulosus tubulin alpha chain 0.0604 0.3658 0.74
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0417 0.0844
Echinococcus multilocularis tubulin subunit beta 0.0811 0.4943 0.4942
Brugia malayi map kinase activated protein kinase protein 2 0.0217 0.1269 0.2567
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Schistosoma mansoni DNA helicase recq5 0.0029 0.0102 0.0192
Schistosoma mansoni tyrosine kinase 0.0304 0.1806 0.3645
Echinococcus multilocularis epidermal growth factor receptor 0.0304 0.1806 0.1804
Echinococcus granulosus agrin 0.0038 0.0161 0.0321
Brugia malayi protein-tyrosine kinase 0.0042 0.0182 0.0367
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0365 0.0725
Schistosoma mansoni tubulin subunit alpha 0.0604 0.3658 0.7397
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 0.0417 0.0844
Schistosoma mansoni tyrosine kinase 0.01 0.0541 0.1083
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0154 0.0311
Trypanosoma cruzi alpha tubulin, putative 0.0604 0.3658 0.7401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0738
Plasmodium vivax tubulin epsilon chain, putative 0.0481 0.29 0.5857
Echinococcus multilocularis tubulin alpha chain 0.0604 0.3658 0.3657
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0146 0.0296
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0303 0.06
Trypanosoma cruzi tubulin delta chain 0.0376 0.225 0.4552
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0006 0.0011
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0217 0.1269 0.2564
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0156 0.0154
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0357 0.2134 0.4315
Brugia malayi Tubulin gamma chain 0.0481 0.2902 0.5871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0089 0.0176
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0154 0.0307
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0021 0.0054 0.0095
Brugia malayi Fibronectin type III domain containing protein 0.0024 0.0072 0.0145
Brugia malayi Smad1 0.0016 0.0024 0.0049
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0024 0.0036
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus granulosus lamin 0.0027 0.0091 0.0181
Echinococcus granulosus beta tubulin 0.0811 0.4943 1
Echinococcus granulosus cathepsin l1 0.0017 0.0028 0.0052
Loa Loa (eye worm) steroid hormone receptor 0.008 0.0417 0.0844
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0215 0.0435
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0321 0.0649
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0028 0.0005
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0056 0.0271 0.0548
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0146
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0215 0.0435
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0365 0.0734
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0156 0.0316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Onchocerca volvulus 0.0056 0.0271 0.186
Mycobacterium ulcerans beta-lactamase 0.0071 0.0365 0.3016
Trypanosoma brucei epsilon tubulin 0.0481 0.29 0.5866
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Onchocerca volvulus Protein ultraspiracle homolog 0.008 0.0417 0.2874
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.0041 0.0069
Loa Loa (eye worm) alpha-tubulin 0.0604 0.3658 0.7401
Mycobacterium tuberculosis Conserved protein 0.0071 0.0365 0.1248
Loa Loa (eye worm) TK/INSR protein kinase 0.01 0.0541 0.1095
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0021 0.0043
Schistosoma mansoni DNA helicase recq1 0.0029 0.0102 0.0192
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0223 0.0446
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Toxoplasma gondii cathepsin CPL 0.0017 0.0028 0.0027
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0006 0.0011
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0215 0.0435
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0281 0.2322
Schistosoma mansoni smad1 5 8 and 0.0016 0.0024 0.0036
Loa Loa (eye worm) hypothetical protein 0.0036 0.0146 0.0295
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0335 0.0665
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0533 0.3218 0.3217
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0118 0.0239
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Trichomonas vaginalis tubulin beta chain, putative 0.0604 0.3658 0.74
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0417 0.0844
Mycobacterium ulcerans lipase LipD 0.0071 0.0365 0.3016
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0071 0.0588
Echinococcus multilocularis Tubulin beta 2C chain 0.0811 0.4943 0.4942
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0187 0.0358
Plasmodium falciparum tubulin gamma chain 0.0481 0.2902 0.585
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.0025 0.1101
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Echinococcus granulosus tubulin alpha 1C chain 0.0604 0.3658 0.74
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0117 0.0644 0.1303
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0006 0.0011
Schistosoma mansoni blooms syndrome DNA helicase 0.0015 0.0014 0.0015
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0147 0.0145
Onchocerca volvulus 0.0049 0.0224 0.1535
Entamoeba histolytica tubulin family protein 0.0811 0.4943 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 0.0417 0.0844
Leishmania major eukaryotic initiation factor 4a, putative 0.0025 0.0076 0.0153
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0028 0.0042
Echinococcus multilocularis tubulin epsilon chain 0.0481 0.29 0.2898
Echinococcus granulosus FTZ F1 alpha 0.008 0.0417 0.0841
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0025 0.0076 0.0125
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0068
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0029 0.0102 0.0202
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0109
Schistosoma mansoni intermediate filament proteins 0.0027 0.0091 0.0172
Brugia malayi hypothetical protein 0.0038 0.0156 0.0316
Echinococcus granulosus fibroblast growth factor receptor 4 0.0105 0.0572 0.1153
Echinococcus multilocularis tyrosine protein kinase Srms 0.0042 0.0182 0.0179
Entamoeba histolytica cysteine protease, putative 0.0017 0.0028 0.0034
Mycobacterium tuberculosis Conserved protein 0.0071 0.0365 0.1248
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0148 0.0146
Schistosoma mansoni integrin alpha-ps 0.0069 0.0351 0.0697
Echinococcus granulosus Tubulin beta 2C chain 0.0811 0.4943 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0201 0.1166 0.2348
Leishmania major delta tubulin, putative 0.0376 0.225 0.4552
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0071 0.0122
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0389 0.0738
Plasmodium falciparum thioredoxin reductase 0.0048 0.0218 0.0392
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0021 0.0054 0.0095
Treponema pallidum cell division protein FtsZ 0.0208 0.121 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0417 0.0832
Trypanosoma cruzi cruzipain precursor, putative 0.0064 0.0321 0.0649
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1523 0.3078
Echinococcus granulosus beta LACTamase domain containing family member 0.0071 0.0365 0.0734
Schistosoma mansoni Smad4 0.0016 0.0024 0.0036
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0021 0.0043
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 0.0417 0.0415
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0071 0.0365 0.3016
Brugia malayi beta-lactamase family protein 0.0071 0.0365 0.0738
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0325
Onchocerca volvulus 0.0038 0.0156 0.1067
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0146 0.0296
Onchocerca volvulus 0.0036 0.0148 0.1008
Leishmania major beta tubulin 0.0811 0.4943 1
Echinococcus granulosus integrin alpha ps 0.0069 0.0351 0.0705
Echinococcus granulosus tubulin alpha chain 0.0604 0.3658 0.74
Echinococcus granulosus tyrosine kinase 0.0042 0.0182 0.0363
Schistosoma mansoni integrin beta subunit 0.0186 0.1073 0.216
Loa Loa (eye worm) TK protein kinase 0.0042 0.0182 0.0367
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0215 0.0435
Trichomonas vaginalis tubulin beta chain, putative 0.0604 0.3658 0.74
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0156 0.0316
Loa Loa (eye worm) hypothetical protein 0.0042 0.0184 0.0373
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0025 0.0076 0.0074
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0389 0.0786
Echinococcus multilocularis Tubulin beta 2C chain 0.0811 0.4943 0.4942
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0335 0.0677
Trichomonas vaginalis tubulin, putative 0.0246 0.1447 0.2925
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0028 0.0056
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0156 0.0312
Loa Loa (eye worm) fibroinase 0.0017 0.0028 0.0056
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0156 0.0316
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0161 0.0325
Loa Loa (eye worm) beta-tubulin 0.0811 0.4943 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0071 0.0144
Trichomonas vaginalis tubulin alpha chain, putative 0.0246 0.1447 0.2925
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Schistosoma mansoni tyrosine kinase 0.0105 0.0572 0.1145
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0335 0.0673
Schistosoma mansoni nuclear hormone receptor 0.008 0.0417 0.0832
Plasmodium falciparum tubulin epsilon chain, putative 0.0481 0.29 0.5845
Onchocerca volvulus 0.0017 0.0028 0.0177
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 0.0417 0.0844
Trichomonas vaginalis tubulin epsilon chain, putative 0.0811 0.4943 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0161 0.0297
Schistosoma mansoni tubulin subunit gamma 0.0481 0.2902 0.5866
Onchocerca volvulus Bile acid receptor homolog 0.008 0.0417 0.2874
Schistosoma mansoni hypothetical protein 0.0082 0.0429 0.0856
Brugia malayi conserved hypotetical protein 0.0038 0.0156 0.0316
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0007 0.0014
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 0.0417 0.0832
Echinococcus multilocularis thioredoxin glutathione reductase 0.0048 0.0218 0.0216
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0325
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.018 0.036
Plasmodium falciparum glutathione reductase 0.0048 0.0218 0.0392
Brugia malayi hypothetical protein 0.0042 0.0184 0.0373
Echinococcus multilocularis expressed protein 0.0038 0.0161 0.0159
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0335 0.0677
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0365 0.0738
Brugia malayi Tyrosine-protein kinase abl-1 0.0128 0.0717 0.1451
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0007 0.0005
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.121 0.2444
Brugia malayi eukaryotic initiation factor 4A 0.0025 0.0076 0.0153
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0071 0.0365 0.0738
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0056 0.0271 0.0544
Treponema pallidum ATP-dependent RNA helicase 0.0025 0.0076 0.0514
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0203 0.0412
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0105 0.0572 0.057
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0203 0.0412
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0203 0.0412
Loa Loa (eye worm) hypothetical protein 0.0048 0.022 0.0445
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 0.0417 0.0844
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0013 0.0027
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0071 0.0122
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.0271 0.0548
Schistosoma mansoni tubulin subunit alpha 0.0604 0.3658 0.7397
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0017 0.0035
Leishmania major beta tubulin 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0738
Schistosoma mansoni tubulin subunit beta 0.0811 0.4943 1
Plasmodium vivax hypothetical protein, conserved 0.0071 0.0365 0.0718
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0105 0.0572 0.1153
Schistosoma mansoni alpha tubulin 0.0604 0.3658 0.7397
Mycobacterium tuberculosis Conserved protein 0.0071 0.0365 0.1248
Brugia malayi hypothetical protein 0.0238 0.1397 0.2827
Echinococcus granulosus defective proboscis extension response 0.0021 0.0054 0.0105
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0203 0.0201
Loa Loa (eye worm) hypothetical protein 0.0396 0.2372 0.4798
Loa Loa (eye worm) hypothetical protein 0.0085 0.0448 0.0907
Echinococcus multilocularis hypothetical protein 0.0604 0.3658 0.3657
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.0041 0.0079
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0071 0.0365 0.0738
Echinococcus granulosus integrin alpha ps 0.0033 0.0128 0.0255
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0056 0.0271 0.0269
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0071 0.0365 0.1248
Leishmania major cathepsin L-like protease 0.0017 0.0028 0.0056
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0161 0.0325
Onchocerca volvulus Cathepsin F homolog 0.0017 0.0028 0.0177
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0025 0.0076 0.0153
Echinococcus granulosus ecdysone induced protein 78C 0.008 0.0417 0.0841
Echinococcus granulosus tubulin beta 1 chain 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0325
Brugia malayi Niemann-Pick C1 protein precursor 0.0198 0.1147 0.232
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0223 0.0446
Echinococcus granulosus Tubulin alpha 1 chain 0.0604 0.3658 0.74
Loa Loa (eye worm) tubulin alpha chain 0.0604 0.3658 0.7401
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0024 0.0022
Echinococcus granulosus Protein patched homolog 1 0.0085 0.0448 0.0903
Onchocerca volvulus 0.0017 0.0028 0.0177
Loa Loa (eye worm) hypothetical protein 0.0015 0.0014 0.0029
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0215 0.0414
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.008 0.0417 0.0841
Brugia malayi Integrin alpha pat-2 precursor 0.0154 0.0876 0.1773
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.037 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-49 0.008 0.0417 0.0844
Echinococcus multilocularis epidermal growth factor receptor 0.0165 0.0946 0.0944
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0017 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0017 0.0031
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0004 0.0002
Giardia lamblia Beta tubulin 0.0811 0.4943 1
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0118 0.0217
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus multilocularis peroxisome assembly protein 26 0.0604 0.3658 0.3657
Echinococcus granulosus cpg binding protein 0.0031 0.0113 0.0223
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0207 0.0205
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0028 0.0056
Schistosoma mansoni hypothetical protein 0.0033 0.0128 0.0246
Giardia lamblia Beta tubulin 0.0811 0.4943 1
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0281 0.0568
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0013 0.0027
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 0.0417 0.0841
Schistosoma mansoni hypothetical protein 0.0082 0.0429 0.0856
Toxoplasma gondii alpha tubulin TUBA1 0.0604 0.3658 0.7393
Brugia malayi Tyrosine-protein kinase abl-1 0.0098 0.0533 0.1077
Echinococcus multilocularis Niemann Pick C1 protein 0.0198 0.1147 0.1145
Loa Loa (eye worm) hypothetical protein 0.0085 0.0449 0.0909
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0028 0.0177
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0154 0.029
Trypanosoma cruzi hypothetical protein, conserved 0.0071 0.0365 0.0738
Echinococcus multilocularis smad 0.0016 0.0024 0.0022
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0029 0.0102 0.0202
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1029 0.2079
Trypanosoma brucei alpha tubulin 0.0604 0.3658 0.7401
Echinococcus granulosus Tubulin beta 2C chain 0.0811 0.4943 1
Echinococcus granulosus tubulin alpha chain 0.0604 0.3658 0.74
Schistosoma mansoni lamin 0.0027 0.0091 0.0172
Onchocerca volvulus 0.0029 0.0102 0.0693
Loa Loa (eye worm) hypothetical protein 0.0238 0.1397 0.2827
Brugia malayi tubulin alpha-2 chain 0.0604 0.3658 0.7401
Echinococcus multilocularis protein dispatched 1 0.0097 0.0523 0.0521
Echinococcus granulosus twitchin 0.0025 0.0076 0.0149
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 0.0417 0.0844
Echinococcus granulosus tubulin alpha chain 0.0604 0.3658 0.74
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0054 0.0257 0.052
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.0821 0.1661
Loa Loa (eye worm) hypothetical protein 0.0357 0.2134 0.4318
Leishmania major beta tubulin 0.0811 0.4943 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0165 0.0284
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0215 0.0435
Loa Loa (eye worm) transcription factor SMAD2 0.024 0.1407 0.2846
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0223 0.0221
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0017 0.0035
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0146 0.0291
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1523 0.3078
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Loa Loa (eye worm) tubulin beta chain 0.0811 0.4943 1
Echinococcus granulosus expressed conserved protein 0.0186 0.1073 0.2167
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0102 0.0206
Echinococcus granulosus Solute carrier organic anion transporter family 0.0056 0.0271 0.0544
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0207 0.0418
Schistosoma mansoni hypothetical protein 0.0049 0.0224 0.044
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.0223 0.0221
Trichomonas vaginalis tubulin beta chain, putative 0.0604 0.3658 0.74
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0203 0.0412
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0738
Onchocerca volvulus 0.0071 0.0365 0.251
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Echinococcus multilocularis cysteine protease 0.0017 0.0028 0.0026
Schistosoma mansoni tubulin subunit epsilon 0.0481 0.29 0.5861
Schistosoma mansoni tyrosine kinase 0.0019 0.0041 0.0069
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0006 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.003 0.0107 0.0216
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0448 0.0903
Leishmania major beta tubulin 0.0811 0.4943 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.0223 0.0221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0058 0.0281 0.094
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0109
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0038
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.0025 0.003
Schistosoma mansoni hypothetical protein 0.0072 0.037 0.0737
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0132 0.0238
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0025 0.0076 0.0153
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0215 0.0213
Trichomonas vaginalis tubulin beta chain, putative 0.0604 0.3658 0.74
Toxoplasma gondii thioredoxin reductase 0.0048 0.0218 0.0413
Giardia lamblia GTOR 0.0045 0.0203 0.0362
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0071 0.0168
Leishmania major cathepsin L-like protease 0.0064 0.0321 0.0649
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0121 0.0671 0.2373
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0058 0.0281 0.0555
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0034 0.0017
Brugia malayi Tubulin alpha chain 0.0604 0.3658 0.7401
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0207 0.0405
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0127 0.0708 0.0706
Brugia malayi Cell division protein ftsZ 0.0208 0.121 0.2447
Echinococcus multilocularis tubulin alpha 3 chain 0.0604 0.3658 0.3657
Echinococcus granulosus L aminoadipate semialdehyde 0.0167 0.0956 0.1932
Loa Loa (eye worm) ctsf protein 0.0017 0.0028 0.0056
Entamoeba histolytica recQ family DNA helicase 0.0015 0.0014 0.0007
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 0.0417 0.0415
Echinococcus granulosus insulin receptor 0.01 0.0541 0.1091
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.0223 0.0446
Schistosoma mansoni hypothetical protein 0.0505 0.3051 0.6167
Trichomonas vaginalis tubulin alpha chain, putative 0.0246 0.1447 0.2925
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0073 0.0119
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Plasmodium vivax RNA helicase-1, putative 0.0025 0.0076 0.0132
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0321 0.0649
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0021 0.0043
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0156 0.0303
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0017 0.0035
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Echinococcus multilocularis beta tubulin 0.0811 0.4943 0.4942
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0284 0.0548
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0335 0.0677
Giardia lamblia Sgs1 DNA helicase, putative 0.0029 0.0102 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0074 0.0146
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0207 0.0418
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0207 0.0414
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.008 0.0417 0.0415
Toxoplasma gondii beta tubulin 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.0025 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Brugia malayi tailless protein 0.0038 0.0156 0.0316
Onchocerca volvulus 0.0246 0.1447 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Echinococcus granulosus intermediate filament protein 0.0027 0.0091 0.0181
Trichomonas vaginalis tubulin gamma chain, putative 0.0811 0.4943 1
Echinococcus multilocularis protein patched 0.0085 0.0448 0.0446
Brugia malayi hypothetical protein 0.0075 0.0389 0.0786
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0028 0.0026
Giardia lamblia Alpha-tubulin 0.0604 0.3658 0.7387
Echinococcus granulosus follistatin 0.0038 0.0161 0.0321
Giardia lamblia Beta tubulin 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0198 0.1147 0.232
Leishmania major hypothetical protein, conserved 0.0075 0.0389 0.0786
Loa Loa (eye worm) tubulin alpha chain 0.0604 0.3658 0.7401
Leishmania major zeta tubulin, putative 0.0489 0.2948 0.5965
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Echinococcus granulosus Immunoglobulin 0.0021 0.0054 0.0105
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0071 0.0588
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 0.0417 0.0844
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0156 0.0312
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0203 0.0391
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.0223 0.0221
Brugia malayi nuclear receptor RXR 0.0038 0.0156 0.0316
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Brugia malayi ecdysone receptor 0.0038 0.0156 0.0316
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0025 0.0052
Onchocerca volvulus 0.0071 0.0365 0.251
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0002 0.0004
Brugia malayi beta-lactamase 0.0071 0.0365 0.0738
Echinococcus multilocularis tyrosine protein kinase HCK 0.0035 0.0139 0.0137
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus granulosus tubulin epsilon chain 0.0481 0.29 0.5864
Brugia malayi MH1 domain containing protein 0.0016 0.0024 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0102 0.0207
Trypanosoma brucei beta tubulin 0.0811 0.4943 1
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0184 0.0182
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Brugia malayi Cathepsin L-like precursor 0.0017 0.0028 0.0056
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0071 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0091 0.0179
Onchocerca volvulus 0.0017 0.0028 0.0177
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0156 0.0312
Loa Loa (eye worm) SRC-1 0.0048 0.0223 0.0451
Leishmania major cathepsin L-like protease 0.0017 0.0028 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0075 0.0389 0.0738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Toxoplasma gondii LsmAD domain-containing protein 0.0075 0.0389 0.0759
Mycobacterium tuberculosis Probable dehydrogenase 0.0109 0.0596 0.2097
Trypanosoma brucei alpha tubulin 0.0604 0.3658 0.7401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0215 0.0213
Brugia malayi sulfakinin receptor protein 0.0225 0.1316 0.2662
Trichomonas vaginalis tubulin, putative 0.0235 0.1378 0.2785
Loa Loa (eye worm) hypothetical protein 0.0013 0.0004 0.0009
Loa Loa (eye worm) BEN-1 protein 0.0811 0.4943 1
Brugia malayi Thioredoxin reductase 0.0048 0.0218 0.0441
Brugia malayi Cathepsin L-like precursor 0.0017 0.0028 0.0056
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0203 0.0391
Onchocerca volvulus 0.005 0.0232 0.1588
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0015 0.0017 0.0035
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0007 0.0009
Leishmania major protein kinase, putative 0.0013 0.0006 0.0011
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0014 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0417 0.0415
Schistosoma mansoni hypothetical protein 0.0412 0.2473 0.4996
Echinococcus multilocularis cysteine protease 0.0017 0.0028 0.0026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0071 0.0365 0.1248
Echinococcus multilocularis beta tubulin 0.0811 0.4943 0.4942
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0102 0.0206
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0047 0.0214 0.0405
Echinococcus granulosus neuropeptide receptor A26 0.0475 0.286 0.5784
Leishmania major phosphatidylinositol 3-kinase, putative 0.0015 0.0017 0.0035
Echinococcus granulosus dnaJ subfamily B 0.0412 0.2473 0.5
Brugia malayi Tubulin alpha-2 chain 0.0604 0.3658 0.7401
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0042 0.0182 0.0179
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.0025 0.021
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0223 0.0221
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0028 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0147
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Loa Loa (eye worm) thioredoxin reductase 0.0048 0.0218 0.0441
Schistosoma mansoni aryl hydrocarbon receptor 0.0049 0.0227 0.0445
Onchocerca volvulus 0.0027 0.0091 0.0618
Echinococcus multilocularis musashi 0.0027 0.0091 0.0089
Toxoplasma gondii protease inhibitor PI2 0.0038 0.0161 0.0297
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Brugia malayi photoreceptor-specific nuclear receptor 0.008 0.0417 0.0844
Brugia malayi Furin-like cysteine rich region family protein 0.0304 0.1806 0.3654
Trypanosoma brucei zeta tubulin, putative 0.0489 0.2948 0.5965
Brugia malayi Sex muscle abnormal protein 5 0.0013 0.0007 0.0014
Brugia malayi MH2 domain containing protein 0.024 0.1407 0.2846
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0017 0.0035
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0091 0.0185
Schistosoma mansoni tubulin subunit alpha 0.0208 0.121 0.2437
Plasmodium vivax tubulin gamma chain, putative 0.0481 0.2902 0.5862
Echinococcus granulosus geminin 0.0505 0.3051 0.617
Leishmania major cathepsin L-like protease 0.0017 0.0028 0.0056
Schistosoma mansoni tubulin subunit beta 0.0811 0.4943 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0481 0.2902 0.2901
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Plasmodium falciparum alpha tubulin 1 0.0604 0.3658 0.7387
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 0.0417 0.0841
Loa Loa (eye worm) hypothetical protein 0.0042 0.0184 0.0373
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0071 0.0122
Echinococcus granulosus tyrosine protein kinase ABL1 0.022 0.1285 0.2597
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0034 0.1493
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0118 0.0239
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0154 0.0261
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0137 0.0771 0.0769
Echinococcus multilocularis tubulin alpha 1C chain 0.0604 0.3658 0.3657
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0156 0.0316
Echinococcus multilocularis tubulin alpha 0.0454 0.2734 0.2732
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0017 0.0031
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0029 0.0102 0.01
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0015 0.0017 0.0035
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0154 0.0311
Trichomonas vaginalis tubulin beta chain, putative 0.0246 0.1447 0.2925
Leishmania major cathepsin L-like protease 0.0064 0.0321 0.0649
Echinococcus granulosus integrin alpha 3 0.0118 0.0654 0.1319
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0034 0.0132 0.013
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0208 0.121 1
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.1397 0.1395
Toxoplasma gondii ABC1 family protein 0.0071 0.0365 0.0711
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0156 0.0154
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0007 0.0014
Schistosoma mansoni tubulin subunit alpha 0.0604 0.3658 0.7397
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 0.0417 0.2874
Loa Loa (eye worm) hypothetical protein 0.0121 0.0672 0.1359
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0025 0.0076 0.0133
Mycobacterium leprae cell division protein FtsZ 0.0208 0.121 1
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0214 0.0383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0091 0.0179
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0058 0.0281 0.2322
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0029 0.0102 0.0155
Schistosoma mansoni tyrosine kinase 0.0019 0.0041 0.0069
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0121 0.0671 0.2373
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0224 0.0453
Echinococcus multilocularis integrin beta 2 0.0234 0.1369 0.1368
Loa Loa (eye worm) hypothetical protein 0.0013 0.0002 0.0004
Brugia malayi ecdysteroid receptor 0.008 0.0417 0.0844
Echinococcus granulosus Niemann Pick C1 protein 0.0198 0.1147 0.2317
Leishmania major beta tubulin 0.0811 0.4943 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0071 0.0571
Brugia malayi hypothetical protein 0.0164 0.0941 0.1903
Loa Loa (eye worm) hypothetical protein 0.0027 0.0088 0.0179
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Schistosoma mansoni hypothetical protein 0.0127 0.0708 0.1421
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0187 0.0351
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Echinococcus granulosus lamin dm0 0.0027 0.0091 0.0181
Brugia malayi Tubulin beta-1 chain 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0034 0.0132 0.0263
Schistosoma mansoni retinoic acid receptor RXR 0.0179 0.1032 0.2077
Brugia malayi Variant SH3 domain containing protein 0.0013 0.0007 0.0014
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0025 0.0076 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.0025 0.0052
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.018 0.0364
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0376 0.225 0.4536
Onchocerca volvulus 0.0038 0.0161 0.1097
Echinococcus multilocularis bloom syndrome protein 0.0041 0.018 0.0178
Leishmania major beta tubulin 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0003
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0028 0.0034
Trypanosoma brucei hypothetical protein, conserved 0.0071 0.0365 0.0738
Loa Loa (eye worm) TK/KIN16 protein kinase 0.003 0.0107 0.0216
Trichomonas vaginalis tubulin beta chain, putative 0.0604 0.3658 0.74
Echinococcus granulosus neuropeptide s receptor 0.0475 0.286 0.5784
Echinococcus multilocularis thyroid hormone receptor alpha 0.0207 0.1202 0.12
Schistosoma mansoni tyrosine kinase 0.0048 0.0223 0.0438
Onchocerca volvulus 0.0017 0.0028 0.0177
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 0.0417 0.0415
Trichomonas vaginalis tubulin beta chain, putative 0.0604 0.3658 0.74
Schistosoma mansoni tyrosine kinase 0.0165 0.0946 0.1903
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0038
Plasmodium vivax delta tubulin, putative 0.0208 0.121 0.2431
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.0025 0.0052
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0058 0.0281 0.0568
Trichomonas vaginalis tubulin beta chain, putative 0.0811 0.4943 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.0041 0.0039
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0456 0.2744 1
Brugia malayi Tubulin alpha-2 chain 0.0604 0.3658 0.7401
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0215 0.0407
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0146 0.0291
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0604 0.3658 0.74
Loa Loa (eye worm) hypothetical protein 0.005 0.0232 0.047
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0007 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0203 0.0407
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Trypanosoma brucei zeta tubulin 0.0489 0.2948 0.5965
Leishmania major hypothetical protein, conserved 0.0071 0.0365 0.0738
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0154 0.0311
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0246 0.1447 0.2925
Trichomonas vaginalis tubulin alpha chain, putative 0.0811 0.4943 1
Echinococcus granulosus epidermal growth factor receptor 0.0304 0.1806 0.3651
Entamoeba histolytica hypothetical protein 0.0047 0.0214 0.0412
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0167 0.0956 0.1935
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0187 0.0375
Schistosoma mansoni serine/threonine protein kinase 0.0217 0.1269 0.2557
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 0.0417 0.0844
Brugia malayi steroid hormone receptor 0.008 0.0417 0.0844
Trypanosoma brucei beta tubulin 0.0811 0.4943 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0481 0.2902 0.5869
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.0025 0.0052
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Loa Loa (eye worm) hypothetical protein 0.005 0.0232 0.0469
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0047 0.0214 0.1591
Schistosoma mansoni smad 0.0016 0.0024 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0028 0.0008
Onchocerca volvulus 0.0038 0.0156 0.1067
Schistosoma mansoni agrin 0.0038 0.0161 0.0312
Loa Loa (eye worm) hypothetical protein 0.0027 0.0092 0.0187
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0017 0.0031
Schistosoma mansoni integrin alpha 0.0154 0.0876 0.1762
Trypanosoma cruzi trypanothione reductase, putative 0.0048 0.0218 0.0441
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0029 0.0102 0.0206
Schistosoma mansoni hypothetical protein 0.0104 0.0568 0.1137
Loa Loa (eye worm) cysteine protease 0.0017 0.0028 0.0056
Leishmania major beta tubulin 0.0811 0.4943 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0017 0.0031
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0071 0.0588
Echinococcus granulosus tyrosine protein kinase HCK 0.0035 0.0139 0.0278
Schistosoma mansoni tubulin subunit beta 0.0811 0.4943 1
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0215 0.0407
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0091 0.0185
Plasmodium vivax tubulin beta chain, putative 0.0811 0.4943 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Brugia malayi nuclear receptor NHR-88 0.008 0.0417 0.0844
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0179 0.1032 0.2084
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0042 0.0182 0.0363
Loa Loa (eye worm) RecQ helicase 0.0041 0.018 0.0364
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0154 0.0307
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0215 0.0697
Loa Loa (eye worm) tubulin alpha 2 0.0396 0.2372 0.4798
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0154 0.0298
Trypanosoma cruzi tubulin delta chain 0.0376 0.225 0.4552
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.0821 0.165
Loa Loa (eye worm) beta-lactamase 0.0071 0.0365 0.0738
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0214
Leishmania major beta tubulin 0.0811 0.4943 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0071 0.0365 0.0363
Loa Loa (eye worm) hypothetical protein 0.0037 0.0154 0.0311
Trypanosoma brucei beta tubulin 0.0454 0.2734 0.5531
Echinococcus granulosus Niemann Pick C1 protein 0.0283 0.1672 0.3379
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0054 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0208 0.121 0.2444
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0028 0.0056
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0059 0.0286 0.0579
Echinococcus granulosus tubulin gamma 1 chain 0.0481 0.2902 0.5869
Loa Loa (eye worm) hypothetical protein 0.0021 0.0054 0.0109
Trypanosoma brucei PAB1-binding protein , putative 0.0075 0.0389 0.0786
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0028 0.0052
Schistosoma mansoni tyrosine kinase 0.0213 0.1243 0.2505
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.0025 0.0047
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0118 0.0234
Brugia malayi sodium-independent organic anion transporter family protein 0.0056 0.0271 0.0548
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0184 0.036
Trichomonas vaginalis tubulin epsilon chain, putative 0.0811 0.4943 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0365 0.0734
Echinococcus multilocularis follistatin 0.0038 0.0161 0.0159
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0109 0.0596 0.2097
Toxoplasma gondii tubulin, putative 0.0027 0.0089 0.0152
Brugia malayi alpha-tubulin 0.0604 0.3658 0.7401
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0156 0.0303
Echinococcus granulosus c src tyrosine kinase 0.0019 0.0041 0.0079
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0025 0.0076 0.014
Onchocerca volvulus 0.0056 0.0271 0.186
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0091 0.0185
Schistosoma mansoni alpha tubulin 0.0604 0.3658 0.7397
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0024 0.0022
Echinococcus multilocularis lamin dm0 0.0027 0.0091 0.0089
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0154 0.0311
Leishmania major trypanothione reductase 0.0048 0.0218 0.0441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.008 0.0417 0.0844
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0215 0.0435
Loa Loa (eye worm) hypothetical protein 0.0042 0.0184 0.0373
Trypanosoma cruzi tubulin gamma chain 0.0481 0.2902 0.5871
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0146 0.0291
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0047 0.0214 0.0412
Loa Loa (eye worm) hypothetical protein 0.0029 0.0102 0.0206
Leishmania major beta tubulin 0.0811 0.4943 1
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.0223 0.0221
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 0.0417 0.0832
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0047 0.0214 0.0405
Echinococcus multilocularis tubulin beta 1 chain 0.0811 0.4943 0.4942
Loa Loa (eye worm) hypothetical protein 0.0167 0.0956 0.1935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0203 0.0407
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0047 0.0214 0.0693
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0015 0.0017 0.0035
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0156 0.0303
Giardia lamblia Epsilon tubulin 0.0235 0.1376 0.2746
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0335 0.0657
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0085 0.0448 0.0907
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0156 0.0312
Trichomonas vaginalis tubulin alpha chain, putative 0.0246 0.1447 0.2925
Brugia malayi beta-tubulin, identical 0.0811 0.4943 1
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0165 0.0946 0.191
Loa Loa (eye worm) hypothetical protein 0.0013 0.0007 0.0014
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0102 0.0177
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0071 0.0365 0.1248
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0109 0.0596 0.2097
Brugia malayi nuclear receptor NHR-88 0.0038 0.0156 0.0316
Echinococcus multilocularis Tubulin beta 2C chain 0.0811 0.4943 0.4942
Trypanosoma cruzi PAB1-binding protein , putative 0.0075 0.0389 0.0786
Echinococcus multilocularis integrin alpha ps 0.0069 0.0351 0.0349
Loa Loa (eye worm) alpha-tubulin 0.0604 0.3658 0.7401
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0335 0.0677
Loa Loa (eye worm) TK protein kinase 0.0108 0.0591 0.1195
Echinococcus granulosus tubulin alpha chain 0.0604 0.3658 0.74
Trypanosoma cruzi zeta tubulin, putative 0.0489 0.2948 0.5965
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0025 0.0076 0.014
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0105 0.0572 0.057
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0024 0.0045
Schistosoma mansoni tyrosine kinase 0.016 0.0912 0.1833
Mycobacterium tuberculosis Probable reductase 0.0109 0.0596 0.2097
Brugia malayi Cathepsin L-like precursor 0.0017 0.0028 0.0056
Echinococcus granulosus tubulin alpha 3 chain 0.0604 0.3658 0.74
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0738
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Loa Loa (eye worm) hypothetical protein 0.0013 0.0001 0.0003
Onchocerca volvulus 0.0017 0.0028 0.0177
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Echinococcus multilocularis integrin alpha 3 0.0118 0.0654 0.0652
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0281 0.0564
Echinococcus multilocularis Tubulin alpha 1 chain 0.0604 0.3658 0.3657
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0028 0.0034
Echinococcus granulosus alpha tubulin 0.0604 0.3658 0.74
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0127 0.0708 0.1429
Echinococcus multilocularis tubulin alpha 3 chain 0.0604 0.3658 0.3657
Brugia malayi Steroid receptor seven-up type 2 0.008 0.0417 0.0844
Echinococcus multilocularis Tubulin beta 2C chain 0.0811 0.4943 0.4942
Echinococcus granulosus epidermal growth factor receptor 0.0165 0.0946 0.191
Mycobacterium tuberculosis Probable esterase LipL 0.0071 0.0365 0.1248
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0203 0.0398
Echinococcus multilocularis agrin 0.0038 0.0161 0.0159
Trypanosoma brucei alpha tubulin 0.0604 0.3658 0.7401
Mycobacterium tuberculosis Probable hydrolase 0.0071 0.0365 0.1248
Mycobacterium ulcerans cell division protein FtsZ 0.0208 0.121 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.1397 0.2823
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0025 0.0076 0.0149
Mycobacterium tuberculosis Probable oxidoreductase 0.0121 0.0671 0.2373
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Echinococcus multilocularis Smad4 0.0016 0.0024 0.0022
Echinococcus multilocularis tubulin delta chain 0.0208 0.121 0.1208
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0417 0.0844
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0028 0.0026
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0052
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0187 0.0375
Echinococcus granulosus tumor protein p63 0.034 0.2029 0.4103
Loa Loa (eye worm) hypothetical protein 0.0085 0.0449 0.0909
Echinococcus multilocularis tyrosine protein kinase Abl 0.0098 0.0533 0.0531
Echinococcus multilocularis 0.0093 0.0499 0.0497
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.0041 0.0039
Toxoplasma gondii alpha-tubulin I, putative 0.0604 0.3658 0.7393
Loa Loa (eye worm) integrin alpha pat-2 0.0237 0.1393 0.2817
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0058 0.0281 0.0279
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.0025 0.0052
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.1523 0.3081
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Brugia malayi hypothetical protein 0.0056 0.0271 0.0548
Echinococcus granulosus tubulin subunit beta 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0029
Plasmodium falciparum eukaryotic initiation factor 4A 0.0025 0.0076 0.0102
Brugia malayi Tubulin alpha chain 0.0208 0.121 0.2447
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0147
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Loa Loa (eye worm) hypothetical protein 0.0025 0.0076 0.0153
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0156 0.1067
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0156 0.0316
Loa Loa (eye worm) hypothetical protein 0.0042 0.0184 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0207 0.0405
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Loa Loa (eye worm) glutathione reductase 0.0048 0.0218 0.0441
Echinococcus granulosus sterol regulatory element binding protein 0.0085 0.0448 0.0903
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 0.0417 0.0832
Mycobacterium tuberculosis Cell division protein FtsZ 0.0208 0.121 0.4356
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0076 0.0149
Brugia malayi beta-lactamase family protein 0.0071 0.0365 0.0738
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Schistosoma mansoni tyrosine kinase 0.0048 0.0223 0.0438
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0121 0.0671 0.5536
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0185
Leishmania major cathepsin L-like protease 0.0017 0.0028 0.0056
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0417 0.0841
Leishmania major epsilon tubulin, putative 0.0481 0.29 0.5866
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0091 0.0179
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0025 0.0076 0.0074
Echinococcus granulosus Tubulin alpha 1 chain 0.0604 0.3658 0.74
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0071 0.0365 0.0725
Echinococcus granulosus Tubulin alpha 1 chain 0.0604 0.3658 0.74
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0335 0.0333
Schistosoma mansoni organic anion transporter 0.0056 0.0271 0.0535
Echinococcus multilocularis tubulin alpha chain 0.0604 0.3658 0.3657
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0215 0.0422
Brugia malayi Integrin beta pat-3 precursor 0.0316 0.1875 0.3794
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0154 0.0298
Giardia lamblia Delta tubulin 0.0208 0.121 0.2408
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0029 0.0102 0.0177
Brugia malayi hypoxia-induced factor 1 0.0152 0.0862 0.1743
Plasmodium falciparum tubulin delta chain, putative 0.0208 0.121 0.2408
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.0025 0.021
Echinococcus multilocularis neuropeptide s receptor 0.0475 0.286 0.2858
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0071 0.0144
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0161 0.0297
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 0.0417 0.0832
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0071 0.0144
Brugia malayi Cathepsin L-like precursor 0.0017 0.0028 0.0056
Brugia malayi hypothetical protein 0.0049 0.0224 0.0453
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0365 0.0734
Leishmania major cathepsin L-like protease 0.0064 0.0321 0.0649
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0417 0.0415
Brugia malayi isocitrate dehydrogenase 0.0047 0.0215 0.0435
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0165 0.0313
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0156 0.0154
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0185
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0024 0.0045
Plasmodium vivax vivapain-2 0.0017 0.0028 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Schistosoma mansoni coup transcription factor 0.008 0.0417 0.0832
Schistosoma mansoni tyrosine kinase 0.01 0.0541 0.1083
Echinococcus granulosus single minded 2 0.0036 0.0148 0.0295
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0215 0.0213
Loa Loa (eye worm) tubulin alpha 2 0.0149 0.0848 0.1715
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.0025 0.021
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0028 0.0005
Brugia malayi PAS domain containing protein 0.0049 0.0227 0.0458
Schistosoma mansoni tyrosine kinase 0.016 0.0912 0.1833
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0043
Echinococcus granulosus bloom syndrome protein 0.0041 0.018 0.036
Schistosoma mansoni cpg binding protein 0.0031 0.0113 0.0214
Loa Loa (eye worm) hypothetical protein 0.0117 0.0644 0.1303
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0024 0.0049
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0076 0.0149
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0232 0.047
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.0025 0.0023
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0417 0.0844
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0028 0.0042
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0103 0.0559 0.1127
Schistosoma mansoni tubulin subunit beta 0.0811 0.4943 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0154 0.0307
Schistosoma mansoni smad1 5 8 and 0.0016 0.0024 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0111 0.0221
Onchocerca volvulus 0.0167 0.0956 0.6604
Trypanosoma brucei tubulin delta chain 0.0376 0.225 0.4552
Brugia malayi Cathepsin L-like precursor 0.0017 0.0028 0.0056
Schistosoma mansoni tubulin subunit delta 0.0208 0.121 0.2437
Schistosoma mansoni alpha tubulin 0.0604 0.3658 0.7397
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0973 0.6717
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0025 0.0076 0.0149
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0132 0.0262
Echinococcus multilocularis GPCR, family 2 0.0016 0.0021 0.0019
Leishmania major beta tubulin 0.0811 0.4943 1
Schistosoma mansoni hypothetical protein 0.0505 0.3051 0.6167
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0145
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0002 0.0004
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0071 0.0144
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0156 0.1067
Schistosoma mansoni hypothetical protein 0.0082 0.0429 0.0856
Trypanosoma brucei hypothetical protein, conserved 0.0047 0.0214 0.0433
Leishmania major beta tubulin 0.0811 0.4943 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0203 0.0412
Leishmania major beta tubulin 0.0811 0.4943 1
Trypanosoma brucei alpha tubulin 0.0604 0.3658 0.7401
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.0821 0.0819
Echinococcus granulosus tm gpcr rhodopsin 0.0533 0.3218 0.6509
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.018 0.036
Echinococcus multilocularis sterol regulatory element binding protein 0.0085 0.0448 0.0446
Schistosoma mansoni cell adhesion molecule 0.0027 0.0091 0.017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0028 0.0008
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0184 0.0373
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Brugia malayi CXXC zinc finger family protein 0.0029 0.0102 0.0207
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Trypanosoma brucei epsilon tubulin 0.0481 0.29 0.5866
Echinococcus granulosus eukaryotic initiation factor 4A 0.0025 0.0076 0.0149
Plasmodium falciparum tubulin beta chain 0.0811 0.4943 1
Brugia malayi nuclear receptor NHR-67 0.0038 0.0156 0.0316
Echinococcus multilocularis Tubulin beta 2C chain 0.0811 0.4943 0.4942
Schistosoma mansoni zinc finger protein 0.0038 0.0156 0.0303
Trypanosoma cruzi epsilon tubulin, putative 0.0481 0.29 0.5866
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0161 0.0297
Trypanosoma brucei beta tubulin 0.0811 0.4943 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0215 0.0385
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0068
Trichomonas vaginalis tubulin epsilon chain, putative 0.0208 0.121 0.2444
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0417 0.0844
Onchocerca volvulus 0.0027 0.0091 0.0618
Echinococcus multilocularis Immunoglobulin 0.0021 0.0054 0.0052
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0004 0.0005
Schistosoma mansoni hypothetical protein 0.0034 0.0134 0.0259
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.1029 0.2079
Schistosoma mansoni integrin alpha-ps 0.0036 0.0146 0.0282
Entamoeba histolytica hypothetical protein 0.0072 0.037 0.0729
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0161 0.0325
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0156 0.0316
Schistosoma mansoni blooms syndrome DNA helicase 0.0027 0.0089 0.0166
Loa Loa (eye worm) BEN-1 protein 0.0811 0.4943 1
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0154 0.0152
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0028 0.0005
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0335 0.0677
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Onchocerca volvulus 0.0024 0.0071 0.0477
Trichomonas vaginalis tubulin epsilon chain, putative 0.0604 0.3658 0.74
Giardia lamblia Alpha-tubulin 0.0604 0.3658 0.7387
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0335 0.0677
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.004 0.008
Entamoeba histolytica protein kinase, putative 0.0035 0.0139 0.0261
Echinococcus granulosus GPCR family 2 0.0016 0.0021 0.0038
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.0025 0.0052
Brugia malayi Protein kinase domain containing protein 0.01 0.0541 0.1095
Brugia malayi MH1 domain containing protein 0.0016 0.0024 0.0049
Schistosoma mansoni vesicular amine transporter 0.0021 0.0054 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0145
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0232 0.0455
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0154 0.0311
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0015 0.0017 0.0015
Schistosoma mansoni tubulin subunit beta 0.0811 0.4943 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0071 0.0588
Echinococcus granulosus tyrosine protein kinase Blk 0.0042 0.0182 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 0.0417 0.0844
Echinococcus granulosus integrin beta 2 0.0234 0.1369 0.2767
Schistosoma mansoni thyroid hormone receptor 0.0207 0.1202 0.2421
Toxoplasma gondii beta-1 tubulin, putative 0.0811 0.4943 1
Trypanosoma brucei epsilon tubulin 0.0454 0.2734 0.5531
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0162 0.0325
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0038
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0144
Echinococcus multilocularis tubulin alpha 1C chain 0.0604 0.3658 0.3657
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0109 0.0596 0.2097
Trichomonas vaginalis tubulin, putative 0.0811 0.4943 1
Schistosoma mansoni nuclear receptor 0.0038 0.0156 0.0303
Trichomonas vaginalis tubulin gamma chain, putative 0.0208 0.121 0.2444
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0156 0.0316
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 0.0417 0.0832
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0028 0.0026
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0417 0.0841
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1523 0.3078
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0161 0.0323
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0203 0.0407
Brugia malayi tubulin alpha chain - mouse 0.0604 0.3658 0.7401
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.037 0.0737
Loa Loa (eye worm) hypothetical protein 0.0024 0.0072 0.0145
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.0223 0.0446
Trichomonas vaginalis PIKK family atypical protein kinase 0.0015 0.0017 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0021 0.0019
Plasmodium vivax tubulin alpha chain, putative 0.0604 0.3658 0.7395
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0071 0.0144
Schistosoma mansoni tyrosine kinase 0.016 0.0912 0.1833
Brugia malayi MH2 domain containing protein 0.0016 0.0024 0.0049
Loa Loa (eye worm) acetyltransferase 0.0145 0.0821 0.1661
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 0.0417 0.0844
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.0025 0.0052
Mycobacterium tuberculosis Probable lipase LipE 0.0071 0.0365 0.1248
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0144
Loa Loa (eye worm) hypothetical protein 0.0027 0.0091 0.0185
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0232 0.047
Schistosoma mansoni cpg binding protein 0.0029 0.0102 0.0194
Loa Loa (eye worm) TK/EGFR protein kinase 0.0304 0.1806 0.3654
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0232 0.047
Echinococcus granulosus tubulin subunit TubB 0.0604 0.3658 0.74
Echinococcus granulosus tubulin alpha 0.0454 0.2734 0.5529
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 0.0417 0.0844
Trypanosoma brucei beta tubulin 0.0811 0.4943 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 0.0417 0.0844
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0235 0.1376 0.2762
Mycobacterium leprae conserved hypothetical protein 0.0047 0.0214 0.1754
Loa Loa (eye worm) TK/ABL protein kinase 0.022 0.1285 0.26
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0068
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0056 0.0271 0.0269
Loa Loa (eye worm) Smad1 0.0016 0.0024 0.0049
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0147
Mycobacterium ulcerans hypothetical protein 0.0071 0.0365 0.3016
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.2473 0.2471
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0203 0.0412
Brugia malayi SPARC precursor 0.0038 0.0161 0.0325
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0156 0.0316
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0147
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0071 0.0571
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0154 0.0307
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0165 0.0284
Onchocerca volvulus Putative organic anion transporter 0.0056 0.0271 0.186
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.0161 0.0325
Trichomonas vaginalis tubulin epsilon chain, putative 0.0604 0.3658 0.74
Toxoplasma gondii beta-tubulin, putative 0.0811 0.4943 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0203 0.0412
Echinococcus granulosus neuroglian 0.0024 0.0072 0.0142
Mycobacterium leprae conserved hypothetical protein 0.0071 0.0365 0.3004
Treponema pallidum NADH oxidase 0.0017 0.0025 0.0094
Schistosoma mansoni hypothetical protein 0.0082 0.0429 0.0856
Leishmania major beta tubulin 0.0811 0.4943 1
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0047 0.0214 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0207 0.0205
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0198 0.1147 0.2303
Entamoeba histolytica hypothetical protein 0.0072 0.037 0.0729
Loa Loa (eye worm) tubulin beta-1 chain 0.0811 0.4943 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0207 0.0405
Brugia malayi hypothetical protein 0.0056 0.0271 0.0548
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0144
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0015 0.0014 0.0029
Echinococcus multilocularis lamin 0.0027 0.0091 0.0089
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0071 0.0588
Brugia malayi Tubulin beta chain 0.0246 0.1447 0.2928
Echinococcus multilocularis Tubulin alpha 1 chain 0.0604 0.3658 0.3657
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0048 0.022 0.0445
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0134 0.0272
Trypanosoma cruzi beta tubulin, putative 0.0811 0.4943 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Schistosoma mansoni survival motor neuron protein 0.0049 0.0224 0.044
Onchocerca volvulus 0.0071 0.0365 0.251
Trypanosoma cruzi major cysteine proteinase, putative 0.0051 0.0236 0.0477
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0013 0.0002 0.0004
Trypanosoma cruzi MFS transporter, putative 0.0056 0.0271 0.0548
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0203 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0075 0.0147
Echinococcus multilocularis neuroglian 0.0024 0.0072 0.007
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0184 0.0373
Echinococcus multilocularis roundabout 2 0.003 0.0109 0.0107
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0029 0.0102 0.01
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0215 0.0213
Schistosoma mansoni lamin 0.0027 0.0091 0.0172
Echinococcus multilocularis tyrosine protein kinase Blk 0.0042 0.0182 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0146 0.0291
Schistosoma mansoni nuclear receptor 0.0038 0.0156 0.0303
Brugia malayi SRC-1 0.0048 0.0223 0.0451
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0034 0.0279
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0146 0.0296
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0207 0.0414
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0154 0.0152
Echinococcus multilocularis tubulin alpha chain 0.0604 0.3658 0.3657
Mycobacterium ulcerans hypothetical protein 0.0024 0.0071 0.0588
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0118 0.0239
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1523 0.3078
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0148 0.0299
Echinococcus multilocularis integrin alpha ps 0.0033 0.0128 0.0126
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Leishmania major beta tubulin 0.0811 0.4943 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Loa Loa (eye worm) tubulin gamma chain 0.0481 0.2902 0.5871
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0028 0.0008
Echinococcus multilocularis cpg binding protein 0.0031 0.0113 0.011
Loa Loa (eye worm) tubulin beta chain 0.0208 0.121 0.2447
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.0223 0.0446
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0187 0.0351
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.0025 0.0023
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.1523 0.3081
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Trypanosoma brucei alpha tubulin, putative 0.0246 0.1447 0.2928
Leishmania major alpha tubulin 0.0604 0.3658 0.7401
Trypanosoma cruzi cysteine peptidase, putative 0.0064 0.0321 0.0649
Onchocerca volvulus 0.008 0.0417 0.2874
Brugia malayi hypothetical protein 0.0024 0.0072 0.0145
Leishmania major beta tubulin 0.0811 0.4943 1
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.0161 0.0325
Echinococcus granulosus tubulin delta chain 0.0208 0.121 0.2444
Brugia malayi Tubulin beta chain 0.0208 0.121 0.2447
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0156 0.0316
Loa Loa (eye worm) TK protein kinase 0.0035 0.0139 0.0282
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Loa Loa (eye worm) DR-78 0.0038 0.0156 0.0316
Mycobacterium leprae Probable lipase LipE 0.0071 0.0365 0.3004
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0156 0.0312
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.0025 0.0047
Loa Loa (eye worm) hypothetical protein 0.0164 0.0941 0.1903
Onchocerca volvulus Putative organic anion transporter 0.0056 0.0271 0.186
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0217 0.1269 0.1267
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0161 0.0159
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0203 0.0407
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0047 0.0214 0.1768
Plasmodium vivax thioredoxin reductase, putative 0.0048 0.0218 0.042
Trichomonas vaginalis penicillin-binding protein, putative 0.0071 0.0365 0.0734
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0156 0.0154
Loa Loa (eye worm) hypothetical protein 0.0604 0.3658 0.7401
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0105 0.0209
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 0.0417 0.0832
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0156 0.0312
Echinococcus multilocularis tubulin alpha chain 0.0604 0.3658 0.3657
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0047 0.0214 0.167
Loa Loa (eye worm) hypothetical protein 0.0038 0.0156 0.0316
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0154 0.0307
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Onchocerca volvulus Cathepsin L homolog 0.0017 0.0028 0.0177
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0021 0.0019
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0028 0.0052
Schistosoma mansoni nephrin 0.0027 0.009 0.0169
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0029
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0034 0.003
Loa Loa (eye worm) hypothetical protein 0.0225 0.1316 0.2662
Echinococcus granulosus beta tubulin 0.0811 0.4943 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0481 0.29 0.5864
Schistosoma mansoni tubulin subunit beta 0.0811 0.4943 1
Leishmania major beta tubulin 0.0811 0.4943 1
Trypanosoma cruzi zeta tubulin, putative 0.0489 0.2948 0.5965
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.0161 0.0325
Trichomonas vaginalis tubulin alpha chain, putative 0.0454 0.2734 0.5529
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0811 0.4943 0.4942
Brugia malayi hypothetical protein 0.0038 0.0156 0.0316
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0073 0.0143
Onchocerca volvulus 0.0017 0.0028 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0071 0.0365 0.0734
Loa Loa (eye worm) tubulin beta-2A chain 0.0811 0.4943 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0109 0.0596 0.4914
Onchocerca volvulus 0.0056 0.0271 0.186
Brugia malayi MH2 domain containing protein 0.0016 0.0024 0.0049
Onchocerca volvulus Putative organic anion transporter 0.0056 0.0271 0.186
Loa Loa (eye worm) hypothetical protein 0.0018 0.0034 0.0068
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0028 0.0008
Loa Loa (eye worm) tubulin beta-4 chain 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0738
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0184 0.0373
Echinococcus granulosus thioredoxin glutathione reductase 0.0048 0.0218 0.0437
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0028 0.0056
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.0223 0.0221
Echinococcus multilocularis integrin alpha ps 0.0069 0.0351 0.0349
Loa Loa (eye worm) MH2 domain-containing protein 0.024 0.1407 0.2846
Loa Loa (eye worm) hypothetical protein 0.0042 0.0184 0.0373
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0973 0.1965
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0417 0.0844
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0007 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.037 0.0745
Loa Loa (eye worm) hypothetical protein 0.008 0.0417 0.0844
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0056 0.0113
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0071 0.0588
Brugia malayi prostaglandin transporter 0.0056 0.0271 0.0548
Brugia malayi Kelch motif family protein 0.0048 0.022 0.0445
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0028 0.0026
Mycobacterium tuberculosis Probable lipase LipD 0.0071 0.0365 0.1248
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0015 0.0017 0.0031
Echinococcus granulosus tubulin alpha 3 chain 0.0604 0.3658 0.74
Entamoeba histolytica tubulin alpha-1 chain 0.0604 0.3658 0.7395
Echinococcus multilocularis Niemann Pick C1 protein 0.0283 0.1672 0.167
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0071 0.0144
Echinococcus multilocularis FTZ F1 alpha 0.008 0.0417 0.0415
Trypanosoma brucei tubulin gamma chain 0.0481 0.2902 0.5871
Trypanosoma brucei trypanothione reductase 0.0048 0.0218 0.0441
Schistosoma mansoni thyroid hormone receptor 0.0207 0.1202 0.2421
Brugia malayi Immunoglobulin I-set domain containing protein 0.0108 0.0591 0.1195
Brugia malayi nuclear hormone receptor 0.008 0.0417 0.0844
Schistosoma mansoni follistatin 0.0038 0.0161 0.0312
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0454 0.2734 0.5518
Echinococcus granulosus tubulin alpha 1C chain 0.0604 0.3658 0.74
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.0025 0.0052
Leishmania major protein kinase, putative 0.0013 0.0006 0.0011
Trichomonas vaginalis tubulin, putative 0.0246 0.1447 0.2925
Echinococcus multilocularis expressed conserved protein 0.0186 0.1073 0.1071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0089 0.0176
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.1523 0.3078
Echinococcus multilocularis ecdysone induced protein 78C 0.008 0.0417 0.0415
Brugia malayi hypothetical protein 0.0048 0.022 0.0445
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.0025 0.0047
Leishmania major beta tubulin 0.0811 0.4943 1
Echinococcus multilocularis Tubulin alpha 1 chain 0.0604 0.3658 0.3657
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0025 0.0076 0.0153
Brugia malayi nuclear hormone receptor 0.0038 0.0156 0.0316
Echinococcus multilocularis Immunoglobulin 0.0021 0.0054 0.0052
Schistosoma mansoni patched 1 0.0085 0.0448 0.0895
Schistosoma mansoni hypothetical protein 0.0016 0.0021 0.0029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0028 0.0056
Onchocerca volvulus 0.0056 0.0271 0.186
Trypanosoma cruzi epsilon tubulin, putative 0.0481 0.29 0.5866
Echinococcus multilocularis tubulin subunit TubB 0.0604 0.3658 0.3657
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0028 0.0052
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0028 0.0052
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0025 0.0076 0.051
Entamoeba histolytica tubulin gamma chain 0.0481 0.2902 0.5862
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0396 0.2372 0.4796
Echinococcus multilocularis geminin 0.0505 0.3051 0.3049
Echinococcus granulosus Tubulin beta 2C chain 0.0811 0.4943 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0396 0.2372 0.4798
Leishmania major phosphopantetheinyl transferase-like protein 0.0047 0.0214 0.0433
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0071 0.0168
Loa Loa (eye worm) hypoxia-induced factor 1 0.0152 0.0862 0.1743
Plasmodium vivax tubulin alpha chain, putative 0.0604 0.3658 0.7395
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0148 0.1221
Schistosoma mansoni smad1 5 8 and 0.0016 0.0024 0.0036
Brugia malayi nuclear receptor RXR 0.0042 0.0184 0.0373
Mycobacterium ulcerans esterase/lipase LipP 0.0071 0.0365 0.3016
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0146 0.0291
Plasmodium vivax glutathione reductase, putative 0.0048 0.0218 0.042
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0024 0.0049
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.0161 0.0325
Echinococcus granulosus tubulin beta 4A class IVa 0.0811 0.4943 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0161 0.0325
Leishmania major beta tubulin 0.0811 0.4943 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0208 0.121 0.2444
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 0.0417 0.0844
Brugia malayi intermediate filament protein 0.0027 0.0091 0.0185
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Brugia malayi glutathione reductase 0.0048 0.0218 0.0441
Brugia malayi CHE-14 protein 0.0085 0.0448 0.0907
Schistosoma mansoni tubulin subunit beta 0.0208 0.121 0.2437
Entamoeba histolytica hypothetical protein 0.0072 0.037 0.0729
Echinococcus granulosus Smad4 0.0016 0.0024 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0064 0.0321 0.0649
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0154 0.0307
Echinococcus granulosus smad 0.0016 0.0024 0.0045
Loa Loa (eye worm) integrin beta-2 0.0316 0.1875 0.3794
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0217 0.1269 0.2567
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0184 0.0369
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.0223 0.0446
Brugia malayi hypothetical protein 0.0072 0.037 0.0749
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0738
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0215 0.0213
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0103 0.0559 0.0557
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 0.0417 0.0841
Echinococcus multilocularis tyrosine protein kinase ABL1 0.022 0.1285 0.1284
Entamoeba histolytica tubulin alpha chain, putative 0.0604 0.3658 0.7395
Entamoeba histolytica hypothetical protein 0.0072 0.037 0.0729
Leishmania major gamma-tubulin 0.0481 0.2902 0.5871
Loa Loa (eye worm) hypothetical protein 0.0056 0.0271 0.0548
Echinococcus multilocularis insulin receptor 0.01 0.0541 0.0539
Onchocerca volvulus 0.0017 0.0028 0.0177
Schistosoma mansoni single-minded 0.0049 0.0227 0.0445
Onchocerca volvulus 0.0056 0.0271 0.186
Giardia lamblia Gamma tubulin 0.0481 0.2902 0.585

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.171 uM Inhibition of MK2 ChEMBL. 17480064
IC50 (binding) = 0.171 uM Inhibition of MK2 ChEMBL. 17480064
IC50 (functional) = 3.8 uM Inhibition of TNFalpha production in U937 cells ChEMBL. 17480064
IC50 (functional) = 3.8 uM Inhibition of TNFalpha production in U937 cells ChEMBL. 17480064

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 17480064

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.