Detailed information for compound 425649

Basic information

Technical information
  • TDR Targets ID: 425649
  • Name: 7-(2-dimethylaminoethyloxy)-8-methyl-4-pipera zin-1-ylchromen-2-one
  • MW: 331.409 | Formula: C18H25N3O3
  • H donors: 1 H acceptors: 1 LogP: 1.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOc1ccc2c(c1C)oc(=O)cc2N1CCNCC1)C
  • InChi: 1S/C18H25N3O3/c1-13-16(23-11-10-20(2)3)5-4-14-15(12-17(22)24-18(13)14)21-8-6-19-7-9-21/h4-5,12,19H,6-11H2,1-3H3
  • InChiKey: ILUUTXDPEAQXKO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 7-(2-dimethylaminoethyloxy)-8-methyl-4-piperazin-1-yl-chromen-2-one
  • 7-(2-dimethylaminoethyloxy)-8-methyl-4-(1-piperazinyl)-1-benzopyran-2-one
  • 7-(2-dimethylaminoethyloxy)-8-methyl-4-piperazino-coumarin
  • 7-(2-dimethylaminoethoxy)-8-methyl-4-piperazin-1-ylchromen-2-one
  • 7-(2-dimethylaminoethoxy)-8-methyl-4-piperazin-1-yl-chromen-2-one
  • 7-(2-dimethylaminoethoxy)-8-methyl-4-(1-piperazinyl)-2-chromenone
  • 7-(2-dimethylaminoethoxy)-8-methyl-4-piperazin-1-yl-coumarin

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0152 0.0295
Echinococcus granulosus tumor protein p63 0.0333 0.2021 0.4085
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.006 0.0343
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0023 0.044
Echinococcus multilocularis thyroid hormone receptor alpha 0.0202 0.1193 0.1187
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0179
Onchocerca volvulus 0.0049 0.0221 0.1436
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Brugia malayi Protein kinase domain containing protein 0.0098 0.0531 0.1071
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0273
Brugia malayi SPARC precursor 0.0038 0.015 0.0299
Trypanosoma brucei epsilon tubulin 0.0471 0.2892 0.5852
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.0407 0.082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0017 0.0017 0.0005
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.006 0.0385
Schistosoma mansoni tyrosine kinase 0.0047 0.0212 0.0423
Trypanosoma brucei tubulin delta chain 0.0368 0.2241 0.4532
Brugia malayi Tubulin gamma chain 0.0472 0.2894 0.586
Schistosoma mansoni integrin alpha-ps 0.0035 0.0135 0.0267
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0241 0.1438 0.2903
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0285
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0146 0.0907
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0438 0.0432
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0023 0.007
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0146 0.029
Loa Loa (eye worm) hypothetical protein 0.005 0.0226 0.0453
Echinococcus granulosus bloom syndrome protein 0.0041 0.0169 0.033
Brugia malayi hypothetical protein 0.0071 0.036 0.0724
Echinococcus granulosus tubulin alpha chain 0.0591 0.3651 0.7392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0151 0.0293
Echinococcus granulosus cathepsin l cysteine peptidase 0.0017 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0246
Leishmania major beta tubulin 0.0795 0.4937 1
Brugia malayi Tubulin beta-1 chain 0.0795 0.4937 1
Echinococcus granulosus insulin receptor 0.0098 0.0531 0.1063
Echinococcus granulosus tyrosine protein kinase Src64B 0.0047 0.0212 0.0417
Echinococcus granulosus tubulin beta 1 chain 0.0795 0.4937 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0071 0.036 0.0717
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0199
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0015 0.0017
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0078
Echinococcus multilocularis tubulin alpha chain 0.0591 0.3651 0.3647
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1388 0.1382
Trichomonas vaginalis tubulin beta chain, putative 0.0591 0.3651 0.7392
Echinococcus granulosus fibroblast growth factor receptor 4 0.0103 0.0562 0.1126
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0015 0.0023
Echinococcus multilocularis bloom syndrome protein 0.0041 0.0169 0.0163
Echinococcus multilocularis hypothetical protein 0.0591 0.3651 0.3647
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0065 0.0125
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0021
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0114 0.0634 0.128
Echinococcus granulosus tm gpcr rhodopsin 0.0522 0.3211 0.6498
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0146 0.0288
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0107 0.0204
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0179
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.027 0.1918
Leishmania major beta tubulin 0.0795 0.4937 1
Trypanosoma brucei zeta tubulin, putative 0.0479 0.2941 0.5951
Schistosoma mansoni patched 1 0.0083 0.0438 0.0881
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0006 0.0006
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0023
Leishmania major beta tubulin 0.0795 0.4937 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0137 0.0918
Onchocerca volvulus 0.0055 0.026 0.1713
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0065 0.0119
Loa Loa (eye worm) TK/INSR protein kinase 0.0098 0.0531 0.1071
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.031 0.0622
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0155 0.0313
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0062 0.0119
Onchocerca volvulus 0.0036 0.0137 0.0846
Trypanosoma cruzi MFS transporter, putative 0.0055 0.026 0.0521
Echinococcus granulosus tubulin subunit TubB 0.0591 0.3651 0.7392
Echinococcus granulosus beta tubulin 0.0795 0.4937 1
Schistosoma mansoni hypothetical protein 0.0048 0.0213 0.0425
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Schistosoma mansoni hypothetical protein 0.0071 0.036 0.0723
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0081 0.0158
Loa Loa (eye worm) TK protein kinase 0.0106 0.058 0.1171
Loa Loa (eye worm) agrin synaptic family protein 0.0038 0.015 0.0299
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0273
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0283
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0171 0.0334
Leishmania major hypothetical protein, conserved 0.005 0.0226 0.0445
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.0707 0.1428
Entamoeba histolytica tubulin alpha chain, putative 0.0591 0.3651 0.7395
Echinococcus granulosus tyrosine kinase 0.0041 0.0171 0.0334
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0062 0.0113
Plasmodium falciparum tubulin beta chain 0.0795 0.4937 1
Echinococcus granulosus tubulin alpha chain 0.0591 0.3651 0.7392
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.0407 0.0812
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0137 0.0265
Mycobacterium ulcerans cell division protein FtsZ 0.0204 0.12 1
Echinococcus granulosus tubulin alpha 3 chain 0.0591 0.3651 0.7392
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0023 0.0046
Echinococcus granulosus neuropeptide s receptor 0.0465 0.2852 0.5771
Echinococcus granulosus cathepsin L cysteine proteinase 0.0017 0.0017 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.027 0.2157
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0047 0.0212 0.0206
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Brugia malayi secreted modular calcium-binding protein 1 0.0038 0.015 0.0299
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0283
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Schistosoma mansoni thyroid hormone receptor 0.0202 0.1193 0.241
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0146
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.031 0.0622
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Echinococcus multilocularis tyrosine protein kinase Abl 0.0096 0.0522 0.0516
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Echinococcus multilocularis tubulin beta 1 chain 0.0795 0.4937 0.4934
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0017 0.0017 0.0029
Entamoeba histolytica hypothetical protein 0.0071 0.036 0.0729
Loa Loa (eye worm) TK protein kinase 0.0041 0.0171 0.0341
Plasmodium falciparum tubulin epsilon chain, putative 0.0471 0.2892 0.5845
Leishmania major beta tubulin 0.0795 0.4937 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0274 0.0548
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.026 0.0254
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0137 0.0265
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Echinococcus multilocularis geminin 0.0333 0.202 0.2015
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0015 0.0023
Echinococcus granulosus roundabout 2 0.0029 0.0098 0.0187
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Toxoplasma gondii protease inhibitor PI2 0.0038 0.015 0.0297
Onchocerca volvulus 0.0055 0.026 0.1713
Leishmania major trypanothione reductase 0.0047 0.0207 0.0408
Loa Loa (eye worm) tubulin alpha-2 chain 0.0591 0.3651 0.7394
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0065 0.0059
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0203 0.0399
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.0407 0.082
Brugia malayi hypothetical protein 0.0221 0.1306 0.2642
Echinococcus granulosus cpg binding protein 0.003 0.0102 0.0193
Trichomonas vaginalis esterase, putative 0.0036 0.0137 0.0265
Entamoeba histolytica hypothetical protein 0.0071 0.036 0.0729
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.167
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0047 0.0212 0.0206
Brugia malayi Tubulin beta chain 0.0241 0.1438 0.2909
Brugia malayi acetyltransferase, GNAT family protein 0.0142 0.0811 0.1638
Toxoplasma gondii alpha tubulin TUBA1 0.0591 0.3651 0.7393
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0207 0.042
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0017
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0065 0.0119
Echinococcus multilocularis tubulin alpha chain 0.0591 0.3651 0.3647
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.0407 0.0818
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.015 0.0299
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0143 0.0277
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Leishmania major beta tubulin 0.0795 0.4937 1
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.0383
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0407 0.082
Echinococcus granulosus integrin alpha 3 0.0116 0.0644 0.1293
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0253 0.1514 0.3062
Plasmodium falciparum alpha tubulin 1 0.0591 0.3651 0.7387
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0017 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Trichomonas vaginalis tubulin epsilon chain, putative 0.0795 0.4937 1
Brugia malayi beta-lactamase family protein 0.0036 0.0137 0.0273
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0226 0.0429
Treponema pallidum cell division protein FtsZ 0.0204 0.12 1
Schistosoma mansoni integrin alpha-ps 0.0068 0.034 0.0682
Schistosoma mansoni tubulin subunit beta 0.0204 0.12 0.2426
Trichomonas vaginalis tubulin, putative 0.0241 0.1438 0.2903
Brugia malayi Bloom's syndrome protein homolog 0.0041 0.0169 0.0338
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0136 0.0262
Schistosoma mansoni follistatin 0.0038 0.015 0.0297
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0795 0.4937 0.4934
Loa Loa (eye worm) tubulin alpha 2 0.0388 0.2363 0.4784
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0008
Echinococcus granulosus Tubulin alpha 1 chain 0.0591 0.3651 0.7392
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.001 0.0004
Schistosoma mansoni tyrosine kinase 0.0156 0.0902 0.1821
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0146 0.0282
Loa Loa (eye worm) tubulin beta-1 chain 0.0795 0.4937 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.003 0.0054
Trichomonas vaginalis tubulin alpha chain, putative 0.0445 0.2726 0.5515
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.027 0.0535
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.026 0.0515
Toxoplasma gondii beta-tubulin, putative 0.0795 0.4937 1
Echinococcus granulosus tubulin alpha chain 0.0591 0.3651 0.7392
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0065 0.0125
Echinococcus granulosus lamin dm0 0.0027 0.0081 0.0151
Leishmania major cathepsin L-like protease 0.0063 0.031 0.0617
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0017 0.0017
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0585 0.4282
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0216 0.0431
Leishmania major hypothetical protein, conserved 0.0036 0.0137 0.0265
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0137 0.0673
Onchocerca volvulus Putative organic anion transporter 0.0055 0.026 0.1713
Echinococcus multilocularis tubulin alpha chain 0.0591 0.3651 0.3647
Trichomonas vaginalis tubulin beta chain, putative 0.0591 0.3651 0.7392
Loa Loa (eye worm) DR-78 0.0037 0.0146 0.029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0146 0.0139
Schistosoma mansoni nephrin 0.0026 0.008 0.0154
Echinococcus multilocularis beta tubulin 0.0795 0.4937 0.4934
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Mycobacterium ulcerans hypothetical protein 0.0036 0.0137 0.1032
Schistosoma mansoni smad 0.0016 0.0014 0.0021
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0299
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.027 0.0535
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0171 0.0165
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0246 0.0494
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0049 0.0221 0.0443
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.0407 0.2745
Trypanosoma cruzi tubulin delta chain 0.0368 0.2241 0.4536
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0193 0.0378
Brugia malayi Latrophilin receptor protein 2 0.0015 0.001 0.0016
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Brugia malayi Thioredoxin reductase 0.0047 0.0207 0.0415
Brugia malayi Fibronectin type III domain containing protein 0.0023 0.0061 0.0118
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Schistosoma mansoni organic anion transporter 0.0055 0.026 0.0521
Leishmania major beta tubulin 0.0795 0.4937 1
Schistosoma mansoni integrin beta subunit 0.0182 0.1063 0.2148
Echinococcus multilocularis tubulin alpha 3 chain 0.0591 0.3651 0.3647
Onchocerca volvulus 0.0028 0.0092 0.0526
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.031 0.0622
Brugia malayi Smad1 0.0016 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0047 0.0209 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Plasmodium falciparum glutathione reductase 0.0047 0.0207 0.0392
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0146 0.029
Echinococcus granulosus c src tyrosine kinase 0.0019 0.003 0.0048
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0146 0.0288
Giardia lamblia Epsilon tubulin 0.023 0.1366 0.2746
Schistosoma mansoni tyrosine kinase 0.0162 0.0936 0.189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0407 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Onchocerca volvulus Glucosylceramidase homolog 0.0166 0.0963 0.6658
Entamoeba histolytica tubulin family protein 0.0795 0.4937 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0795 0.4937 0.4934
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.027 0.0543
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0324 0.065
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.1591
Brugia malayi Furin-like cysteine rich region family protein 0.0298 0.1797 0.3637
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.015 0.0297
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0438 0.0882
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0065 0.0102
Brugia malayi hypothetical protein 0.0233 0.1388 0.2807
Onchocerca volvulus 0.0027 0.0081 0.0449
Brugia malayi beta-tubulin, identical 0.0795 0.4937 1
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0142 0.0811 0.1637
Loa Loa (eye worm) BEN-1 protein 0.0795 0.4937 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0137 0.0271
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.031 0.0622
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0082
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0585 0.4282
Brugia malayi Kelch motif family protein 0.0047 0.0209 0.0419
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0212 0.0417
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0021
Brugia malayi hypothetical protein 0.0047 0.0209 0.0419
Entamoeba histolytica tubulin family protein 0.0795 0.4937 1
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0053 0.0095
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Brugia malayi nuclear hormone receptor 0.0078 0.0407 0.082
Schistosoma mansoni lamin 0.0027 0.0081 0.0157
Echinococcus granulosus tubulin delta chain 0.0204 0.12 0.2421
Onchocerca volvulus 0.0023 0.006 0.0306
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0125
Schistosoma mansoni tyrosine kinase 0.0156 0.0902 0.1821
Schistosoma mansoni tubulin subunit beta 0.0795 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Schistosoma mansoni thyroid hormone receptor 0.0202 0.1193 0.241
Echinococcus granulosus tubulin alpha 0.0445 0.2726 0.5515
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0021
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0091 0.0172
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0017 0.0034
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0015 0.003
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0222 0.0444
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.0407 0.0401
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Leishmania major beta tubulin 0.0795 0.4937 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.0137 0.0918
Loa Loa (eye worm) cysteine protease 0.0017 0.0017 0.0029
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0029 0.0096 0.019
Brugia malayi PAS domain containing protein 0.0048 0.0216 0.0432
Plasmodium vivax tubulin gamma chain, putative 0.0472 0.2894 0.5862
Trichomonas vaginalis tubulin beta chain, putative 0.0795 0.4937 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0081 0.0151
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0137 0.0265
Trichomonas vaginalis DNA helicase recq, putative 0.0041 0.0169 0.033
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.035 0.2126 0.4298
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0158
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Brugia malayi tubulin alpha chain - mouse 0.0591 0.3651 0.7394
Echinococcus granulosus tubulin subunit beta 0.0795 0.4937 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0017 0.0017 0.0005
Echinococcus multilocularis cpg binding protein 0.003 0.0102 0.0095
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0143 0.0285
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0017 0.001
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0146 0.0288
Trypanosoma brucei alpha tubulin 0.0591 0.3651 0.7392
Brugia malayi nuclear receptor RXR 0.0037 0.0146 0.029
Toxoplasma gondii cathepsin CPL 0.0017 0.0017 0.0027
Onchocerca volvulus 0.0038 0.015 0.0936
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.015 0.0297
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.001 0.0008
Brugia malayi tailless protein 0.0037 0.0146 0.029
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.0407 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Trichomonas vaginalis tubulin gamma chain, putative 0.0472 0.2894 0.5857
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0109 0.0216
Trypanosoma brucei alpha tubulin 0.0591 0.3651 0.7392
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0522 0.3211 0.3206
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0137 0.0918
Echinococcus multilocularis roundabout 2 0.0029 0.0098 0.0092
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.012
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.102 0.2055
Trypanosoma brucei beta tubulin 0.0795 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0146 0.0282
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0061 0.0118
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0137 0.0271
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0137 0.0918
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0091 0.0179
Mycobacterium leprae cell division protein FtsZ 0.0204 0.12 1
Loa Loa (eye worm) tubulin gamma chain 0.0472 0.2894 0.586
Loa Loa (eye worm) hypothetical protein 0.0083 0.0438 0.0882
Brugia malayi hypothetical protein 0.0032 0.0115 0.0228
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.001 0.0004
Echinococcus multilocularis Immunoglobulin 0.0021 0.0043 0.0037
Brugia malayi steroid hormone receptor 0.0078 0.0407 0.082
Trichomonas vaginalis tubulin beta chain, putative 0.0241 0.1438 0.2903
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0324 0.0645
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.027 0.2157
Brugia malayi Tyrosine-protein kinase abl-1 0.0096 0.0522 0.1053
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0203 0.0405
Echinococcus granulosus FTZ F1 alpha 0.0078 0.0407 0.0812
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0107 0.021
Trypanosoma brucei epsilon tubulin 0.0471 0.2892 0.5852
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0065 0.0133
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0065 0.0339
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.003 0.0024
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0017 0.0017 0.0029
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Brugia malayi intermediate filament protein 0.0027 0.0081 0.0158
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.006 0.0385
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0103 0.0562 0.0556
Loa Loa (eye worm) TK protein kinase 0.0034 0.0129 0.0255
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0438 0.0875
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0143 0.0277
Echinococcus multilocularis smad 0.0016 0.0014 0.0007
Echinococcus multilocularis epidermal growth factor receptor 0.0162 0.0936 0.093
Echinococcus granulosus geminin 0.0333 0.202 0.4084
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0015 0.0023
Brugia malayi Tubulin alpha chain 0.0591 0.3651 0.7394
Echinococcus granulosus Tubulin beta 2C chain 0.0795 0.4937 1
Echinococcus granulosus tubulin gamma 1 chain 0.0472 0.2894 0.5857
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0698 0.1402
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.008 0.0149
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0324 0.0652
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0015 0.0017
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0017 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1514 0.3057
Loa Loa (eye worm) tubulin alpha chain 0.0591 0.3651 0.7394
Echinococcus multilocularis tubulin alpha 1C chain 0.0591 0.3651 0.3647
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0143 0.0283
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0208
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0227 0.1348 1
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0065 0.0132
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0029
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Loa Loa (eye worm) fibroinase 0.0017 0.0017 0.0029
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0143 0.0277
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0193 0.0378
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.0407 0.082
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0006 0.0008
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0022
Loa Loa (eye worm) SRC-1 0.0047 0.0212 0.0425
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Trypanosoma brucei zeta tubulin 0.0479 0.2941 0.5951
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0324 0.065
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0786 0.1581
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0081 0.0158
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.12 0.2421
Loa Loa (eye worm) hypothetical protein 0.0194 0.1137 0.2299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0146
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0137 0.0918
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0136 0.0262
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.0407 0.0818
Schistosoma mansoni tyrosine kinase 0.0098 0.0531 0.1069
Brugia malayi ecdysone receptor 0.0037 0.0146 0.029
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.0407 0.0818
Echinococcus granulosus Niemann Pick C1 protein 0.0277 0.1663 0.3359
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0109 0.0214
Echinococcus granulosus Tubulin beta 2C chain 0.0795 0.4937 1
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0146 0.0139
Echinococcus granulosus beta tubulin 0.0795 0.4937 1
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0091 0.0172
Loa Loa (eye worm) hypothetical protein 0.0388 0.2363 0.4784
Entamoeba histolytica tubulin gamma chain 0.0472 0.2894 0.5862
Trichomonas vaginalis tubulin alpha chain, putative 0.0795 0.4937 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.0407 0.0812
Brugia malayi prostaglandin transporter 0.0055 0.026 0.0522
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0015 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.0407 0.082
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1514 0.3057
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0137 0.0278
Echinococcus multilocularis Niemann Pick C1 protein 0.0194 0.1137 0.1131
Echinococcus granulosus dnaJ subfamily B 0.0404 0.2464 0.4985
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0193 0.0378
Leishmania major beta tubulin 0.0795 0.4937 1
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.026 0.0254
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0591 0.3651 0.7392
Brugia malayi protein-tyrosine kinase 0.0041 0.0171 0.0341
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0015 0.0017
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0146 0.0288
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Giardia lamblia Beta tubulin 0.0795 0.4937 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0021
Loa Loa (eye worm) tubulin alpha-3 chain 0.035 0.2126 0.4302
Loa Loa (eye worm) glutathione reductase 0.0047 0.0207 0.0415
Echinococcus multilocularis Tubulin beta 2C chain 0.0795 0.4937 0.4934
Trichomonas vaginalis tubulin gamma chain, putative 0.0204 0.12 0.2421
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0047 0.0212 0.0417
Trypanosoma brucei trypanothione reductase 0.0047 0.0207 0.0408
Echinococcus granulosus neuropeptide receptor A26 0.0465 0.2852 0.5771
Trichomonas vaginalis tubulin beta chain, putative 0.0591 0.3651 0.7392
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0158
Echinococcus granulosus single minded 2 0.0036 0.0137 0.0265
Trypanosoma cruzi beta tubulin, putative 0.0795 0.4937 1
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0231
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0146 0.029
Schistosoma mansoni tubulin subunit delta 0.0204 0.12 0.2426
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0585 0.4282
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0193 0.0386
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0196 0.039
Loa Loa (eye worm) ctsf protein 0.0017 0.0017 0.0029
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0193 0.0378
Leishmania major beta tubulin 0.0795 0.4937 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.0852 0.1721
Echinococcus granulosus smad 0.0016 0.0014 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Onchocerca volvulus 0.0055 0.026 0.1713
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0022
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0071 0.036 0.0354
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0164 0.0947 0.1912
Brugia malayi MH2 domain containing protein 0.0235 0.1398 0.2827
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0171 0.0165
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Onchocerca volvulus Putative organic anion transporter 0.0055 0.026 0.1713
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.0212 0.0417
Leishmania major beta tubulin 0.0795 0.4937 1
Brugia malayi Papain family cysteine protease containing protein 0.0017 0.0017 0.0029
Echinococcus multilocularis Tubulin alpha 1 chain 0.0591 0.3651 0.3647
Onchocerca volvulus 0.0036 0.0137 0.0846
Brugia malayi hypothetical protein 0.0041 0.0174 0.0347
Echinococcus granulosus integrin beta 2 0.0229 0.136 0.2745
Loa Loa (eye worm) tubulin alpha chain 0.0591 0.3651 0.7394
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.015 0.0299
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0096 0.019
Schistosoma mansoni tyrosine kinase 0.0156 0.0902 0.1821
Echinococcus multilocularis cysteine protease 0.0017 0.0017 0.001
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0137 0.0273
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Mycobacterium tuberculosis Probable reductase 0.0106 0.0585 0.4282
Brugia malayi hypothetical protein 0.0055 0.026 0.0522
Giardia lamblia GTOR 0.0044 0.0193 0.0362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.0407 0.082
Echinococcus granulosus tubulin alpha chain 0.0591 0.3651 0.7392
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.003 0.0024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) hypothetical protein 0.0017 0.0017 0.0029
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0204 0.12 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.0412
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0177 0.0351
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.0407 0.0812
Schistosoma mansoni tubulin subunit alpha 0.0591 0.3651 0.7393
Echinococcus multilocularis lamin 0.0027 0.0081 0.0074
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0214
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0438 0.0875
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Loa Loa (eye worm) integrin beta-2 0.0309 0.1867 0.3777
Echinococcus multilocularis neuroglian 0.0024 0.0062 0.0055
Schistosoma mansoni tyrosine kinase 0.0019 0.003 0.0054
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.0212 0.0206
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0193 0.0391
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0101 0.0549 0.0543
Leishmania major delta tubulin, putative 0.0368 0.2241 0.4532
Plasmodium vivax tubulin epsilon chain, putative 0.0471 0.2892 0.5857
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0324 0.0645
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0137 0.0265
Brugia malayi conserved hypotetical protein 0.0037 0.0146 0.029
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.0407 0.082
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0014 0.0015
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.018
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.0407 0.082
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0137 0.0273
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0146 0.0288
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.015 0.0297
Brugia malayi tubulin alpha-2 chain 0.0591 0.3651 0.7394
Schistosoma mansoni Smad4 0.0016 0.0014 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0109 0.0103
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0109 0.0103
Trypanosoma brucei beta tubulin 0.0795 0.4937 1
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0207 0.0415
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0017
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0137 0.0918
Entamoeba histolytica cysteine proteinase, putative 0.0017 0.0017 0.0034
Schistosoma mansoni alpha tubulin 0.0591 0.3651 0.7393
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.0407 0.0401
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0143 0.0137
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0388 0.2363 0.478
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0585 0.4282
Trichomonas vaginalis tubulin epsilon chain, putative 0.0591 0.3651 0.7392
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.026 0.0521
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0038 0.015 0.0299
Brugia malayi hypothetical protein 0.0041 0.0174 0.0347
Echinococcus multilocularis tumor protein p63 0.0333 0.2021 0.2016
Echinococcus granulosus tyrosine protein kinase ABL1 0.0216 0.1276 0.2574
Schistosoma mansoni tubulin subunit beta 0.0795 0.4937 1
Schistosoma mansoni retinoic acid receptor RXR 0.0176 0.1022 0.2065
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.0407 0.0401
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0174 0.0347
Brugia malayi CHE-14 protein 0.0083 0.0438 0.0882
Schistosoma mansoni alpha tubulin 0.0591 0.3651 0.7393
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0277
Loa Loa (eye worm) hypothetical protein 0.0221 0.1306 0.2642
Echinococcus granulosus tubulin alpha chain 0.0591 0.3651 0.7392
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0174 0.0167
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0196 0.019
Trypanosoma cruzi tubulin delta chain 0.0368 0.2241 0.4536
Loa Loa (eye worm) tubulin beta chain 0.0795 0.4937 1
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0103 0.0562 0.0556
Brugia malayi nuclear receptor NHR-88 0.0037 0.0146 0.029
Leishmania major beta tubulin 0.0795 0.4937 1
Trypanosoma brucei beta tubulin 0.0795 0.4937 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0143 0.0283
Brugia malayi nuclear receptor NHR-88 0.0078 0.0407 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1514 0.3057
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0661 0.4845
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0065 0.0119
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0222 0.0444
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0015 0.0017
Loa Loa (eye worm) TK/EGFR protein kinase 0.0298 0.1797 0.3637
Leishmania major beta tubulin 0.0795 0.4937 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0203 0.0405
Schistosoma mansoni hypothetical protein 0.0102 0.0558 0.1124
Echinococcus granulosus defective proboscis extension response 0.0021 0.0043 0.0074
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.0407 0.082
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0152
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Onchocerca volvulus 0.0055 0.026 0.1713
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0407 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.001 0.0016
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0153 0.0281
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0021
Echinococcus multilocularis integrin alpha ps 0.0068 0.034 0.0334
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0017 0.0017 0.001
Echinococcus multilocularis Smad4 0.0016 0.0014 0.0007
Trypanosoma cruzi epsilon tubulin, putative 0.0471 0.2892 0.5854
Giardia lamblia Alpha-tubulin 0.0591 0.3651 0.7387
Schistosoma mansoni tubulin subunit gamma 0.0472 0.2894 0.5859
Schistosoma mansoni tubulin subunit beta 0.0795 0.4937 1
Loa Loa (eye worm) Smad1 0.0016 0.0014 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0407 0.0401
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0065 0.0378
Loa Loa (eye worm) hypothetical protein 0.035 0.2126 0.4302
Echinococcus multilocularis follistatin 0.0038 0.015 0.0144
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Schistosoma mansoni tubulin subunit alpha 0.0591 0.3651 0.7393
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0661 0.4845
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0214
Trichomonas vaginalis tubulin alpha chain, putative 0.0241 0.1438 0.2903
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Entamoeba histolytica recQ family DNA helicase 0.0014 0.0003 0.0007
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.0634 0.128
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.023 0.1366 0.2762
Echinococcus multilocularis tubulin alpha 3 chain 0.0591 0.3651 0.3647
Echinococcus multilocularis insulin receptor 0.0098 0.0531 0.0525
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0047 0.0212 0.0206
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0038 0.015 0.0297
Echinococcus granulosus Tubulin beta 2C chain 0.0795 0.4937 1
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0091 0.0155
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0661 0.5265
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0143 0.0137
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.0444
Loa Loa (eye worm) beta-tubulin 0.0795 0.4937 1
Schistosoma mansoni tyrosine kinase 0.0098 0.0531 0.1069
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.026 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0137 0.1032
Echinococcus multilocularis Tubulin alpha 1 chain 0.0591 0.3651 0.3647
Echinococcus granulosus alpha tubulin 0.0591 0.3651 0.7392
Giardia lamblia Delta tubulin 0.0204 0.12 0.2408
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0177 0.0345
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0324 0.065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.0407 0.0812
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0065 0.0119
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0176 0.1022 0.206
Mycobacterium ulcerans lipase LipD 0.0036 0.0137 0.1032
Brugia malayi Integrin beta pat-3 precursor 0.0309 0.1867 0.3777
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Trichomonas vaginalis tubulin gamma chain, putative 0.0471 0.2892 0.5852
Echinococcus granulosus tubulin epsilon chain 0.0471 0.2892 0.5852
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Schistosoma mansoni hypothetical protein 0.0333 0.202 0.4088
Echinococcus granulosus lamin 0.0027 0.0081 0.0151
Trypanosoma brucei alpha tubulin 0.0591 0.3651 0.7392
Trichomonas vaginalis tubulin epsilon chain, putative 0.0795 0.4937 1
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0203 0.1591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0109 0.0208
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0047 0.0212 0.0417
Leishmania major cathepsin L-like protease 0.0063 0.031 0.0617
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0078 0.0151
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0137 0.0918
Schistosoma mansoni organic anion transporter 0.0055 0.026 0.0521
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0109 0.0221
Toxoplasma gondii ABC1 family protein 0.0036 0.0137 0.0271
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0438 0.0875
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0014 0.0022
Leishmania major beta tubulin 0.0795 0.4937 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.006 0.0385
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0174 0.0347
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.0407 0.0812
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0209 0.0419
Echinococcus granulosus tubulin beta 4A class IVa 0.0795 0.4937 1
Schistosoma mansoni tubulin subunit beta 0.0795 0.4937 1
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0137 0.0265
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0213 0.0427
Trypanosoma cruzi zeta tubulin, putative 0.0479 0.2941 0.5953
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Echinococcus multilocularis Tubulin beta 2C chain 0.0795 0.4937 0.4934
Echinococcus multilocularis expressed protein 0.0038 0.015 0.0144
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0222 0.0444
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0129 0.0122
Leishmania major beta tubulin 0.0795 0.4937 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0277 0.1663 0.1657
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0082
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0174 0.0339
Schistosoma mansoni tyrosine kinase 0.0162 0.0936 0.189
Loa Loa (eye worm) RecQ helicase 0.0041 0.0169 0.0338
Leishmania major beta tubulin 0.0795 0.4937 1
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Brugia malayi hypothetical protein 0.0055 0.026 0.0522
Schistosoma mansoni tubulin subunit alpha 0.0591 0.3651 0.7393
Echinococcus granulosus tubulin alpha 3 chain 0.0591 0.3651 0.7392
Echinococcus multilocularis dnaJ subfamily B 0.0404 0.2464 0.246
Loa Loa (eye worm) MH2 domain-containing protein 0.0235 0.1398 0.2827
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0146 0.029
Mycobacterium tuberculosis Conserved protein 0.0036 0.0137 0.0918
Echinococcus granulosus peroxisome assembly protein 26 0.0591 0.3651 0.7392
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0226 0.0445
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0142 0.0811 0.0805
Schistosoma mansoni tubulin subunit alpha 0.0204 0.12 0.2426
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0017 0.0017 0.0021
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0002
Giardia lamblia Beta tubulin 0.0795 0.4937 1
Echinococcus granulosus Tubulin alpha 1 chain 0.0591 0.3651 0.7392
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0193 0.0378
Schistosoma mansoni tubulin subunit epsilon 0.0471 0.2892 0.5854
Mycobacterium leprae Probable lipase LipE 0.0036 0.0137 0.0673
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0029
Plasmodium vivax tubulin alpha chain, putative 0.0591 0.3651 0.7395
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.0407 0.0818
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0015 0.0023
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Entamoeba histolytica hypothetical protein 0.0071 0.036 0.0729
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0193 0.0391
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0137 0.0271
Schistosoma mansoni vesicular amine transporter 0.0021 0.0043 0.008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0014 0.0007
Echinococcus granulosus L aminoadipate semialdehyde 0.0164 0.0947 0.1907
Schistosoma mansoni integrin alpha 0.0151 0.0867 0.1749
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0021
Trichomonas vaginalis tubulin epsilon chain, putative 0.0204 0.12 0.2421
Echinococcus multilocularis cysteine protease 0.0017 0.0017 0.001
Loa Loa (eye worm) tubulin beta-4 chain 0.0795 0.4937 1
Trypanosoma brucei beta tubulin 0.0795 0.4937 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.0407 0.082
Echinococcus granulosus Tubulin alpha 1 chain 0.0591 0.3651 0.7392
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0081 0.0158
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.0407 0.2745
Echinococcus multilocularis expressed conserved protein 0.0182 0.1063 0.1057
Trichomonas vaginalis tubulin beta chain, putative 0.0591 0.3651 0.7392
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0125
Onchocerca volvulus 0.0027 0.0081 0.0449
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Echinococcus multilocularis L aminoadipate semialdehyde 0.0164 0.0947 0.0941
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.003 0.0048
Echinococcus granulosus follistatin 0.0038 0.015 0.0291
Schistosoma mansoni tubulin subunit beta 0.0795 0.4937 1
Echinococcus granulosus tubulin alpha 1C chain 0.0591 0.3651 0.7392
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0146 0.029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0407 0.0812
Echinococcus multilocularis integrin alpha 3 0.0116 0.0644 0.0638
Loa Loa (eye worm) hypothetical protein 0.0161 0.0931 0.1881
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0137 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Schistosoma mansoni survival motor neuron protein 0.0048 0.0213 0.0425
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0407 0.082
Toxoplasma gondii alpha-tubulin I, putative 0.0591 0.3651 0.7393
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0171 0.0334
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0109 0.0192
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0698 0.0692
Schistosoma mansoni tyrosine kinase 0.0103 0.0562 0.1132
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0203 0.1415
Echinococcus multilocularis beta tubulin 0.0795 0.4937 0.4934
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.026 0.0515
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0177 0.0345
Schistosoma mansoni nuclear receptor 0.0037 0.0146 0.0288
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.0407 0.0401
Giardia lamblia Alpha-tubulin 0.0591 0.3651 0.7387
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0121 0.0238
Brugia malayi hypoxia-induced factor 1 0.0149 0.0852 0.1721
Echinococcus multilocularis protein dispatched 1 0.0095 0.0512 0.0506
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0407 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0164 0.0947 0.1913
Brugia malayi hypothetical protein 0.0161 0.0931 0.1881
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0143 0.0277
Echinococcus granulosus epidermal growth factor receptor 0.0162 0.0936 0.1885
Brugia malayi SRC-1 0.0047 0.0212 0.0425
Brugia malayi Niemann-Pick C1 protein precursor 0.0194 0.1137 0.2299
Trichomonas vaginalis tubulin alpha chain, putative 0.0241 0.1438 0.2903
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0585 0.4606
Echinococcus granulosus epidermal growth factor receptor 0.0298 0.1797 0.3632
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0196 0.0392
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Plasmodium vivax delta tubulin, putative 0.0204 0.12 0.2431
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0199
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0407 0.082
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0047 0.0212 0.0206
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0143 0.0277
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.006 0.0385
Trichomonas vaginalis tubulin epsilon chain, putative 0.0591 0.3651 0.7392
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0134 0.0761 0.0755
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0151 0.0144
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0388 0.2363 0.4784
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0203 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0014 0.0015
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0143 0.0137
Echinococcus granulosus Niemann Pick C1 protein 0.0194 0.1137 0.2293
Schistosoma mansoni zinc finger protein 0.0037 0.0146 0.0288
Loa Loa (eye worm) tubulin beta chain 0.0204 0.12 0.2427
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0021 0.0043 0.008
Loa Loa (eye worm) hypothetical protein 0.0027 0.0081 0.0158
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0065 0.0059
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0065 0.0514
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Brugia malayi hypothetical protein 0.0037 0.0146 0.029
Leishmania major epsilon tubulin, putative 0.0471 0.2892 0.5852
Brugia malayi Integrin alpha pat-2 precursor 0.0151 0.0867 0.1751
Toxoplasma gondii thioredoxin reductase 0.0047 0.0207 0.0413
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0017 0.0017
Echinococcus multilocularis musashi 0.0027 0.0081 0.0074
Loa Loa (eye worm) tubulin alpha 2 0.0146 0.0838 0.1693
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0324 0.0652
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0017 0.0017
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0146 0.0139
Echinococcus granulosus twitchin 0.0024 0.0062 0.0112
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0023 0.0062
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0299
Brugia malayi isocitrate dehydrogenase 0.0031 0.0109 0.0216
Echinococcus multilocularis cathepsin L cysteine protease 0.0017 0.0017 0.001
Echinococcus multilocularis Tubulin alpha 1 chain 0.0591 0.3651 0.3647
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Leishmania major gamma-tubulin 0.0472 0.2894 0.5857
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.0407 0.082
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0065 0.0125
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0146 0.0139
Brugia malayi hypothetical protein 0.0037 0.0146 0.029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Schistosoma mansoni tubulin subunit beta 0.0795 0.4937 1
Echinococcus multilocularis protein patched 0.0083 0.0438 0.0432
Brugia malayi alpha-tubulin 0.0591 0.3651 0.7394
Schistosoma mansoni tyrosine kinase 0.0298 0.1797 0.3635
Toxoplasma gondii beta tubulin 0.0795 0.4937 1
Loa Loa (eye worm) tubulin alpha 2 0.0388 0.2363 0.4784
Trypanosoma cruzi cysteine peptidase, putative 0.0017 0.0017 0.0027
Echinococcus granulosus integrin alpha ps 0.0068 0.034 0.0677
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.0407 0.0818
Schistosoma mansoni DNA helicase recq5 0.0028 0.0091 0.0177
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0661 0.4845
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0021
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0137 0.0265
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0146 0.0139
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus multilocularis tubulin alpha 0.0445 0.2726 0.2721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Leishmania major cathepsin L-like protease 0.0063 0.031 0.0617
Entamoeba histolytica hypothetical protein 0.0046 0.0203 0.0412
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Brugia malayi Tubulin alpha chain 0.0204 0.12 0.2427
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0194 0.1137 0.2303
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0146 0.029
Echinococcus multilocularis tubulin epsilon chain 0.0471 0.2892 0.2887
Echinococcus granulosus tubulin alpha 1C chain 0.0591 0.3651 0.7392
Echinococcus multilocularis peroxisome assembly protein 26 0.0591 0.3651 0.3647
Echinococcus granulosus Smad4 0.0016 0.0014 0.0015
Brugia malayi Tubulin beta chain 0.0204 0.12 0.2427
Brugia malayi sulfakinin receptor protein 0.0221 0.1306 0.2642
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0107 0.0204
Onchocerca volvulus Putative organic anion transporter 0.0055 0.026 0.1713
Plasmodium vivax vivapain-2 0.0017 0.0017 0.0034
Onchocerca volvulus 0.0241 0.1438 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0143 0.0277
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.001 0.0016
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0293 0.0586
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0015 0.0023
Trichomonas vaginalis tubulin, putative 0.0241 0.1438 0.2903
Onchocerca volvulus 0.0078 0.0407 0.2745
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0193 0.0384
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1514 0.3057
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0091 0.0085
Loa Loa (eye worm) tubulin beta-2A chain 0.0795 0.4937 1
Echinococcus multilocularis 0.0091 0.0488 0.0482
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0207 0.0201
Echinococcus multilocularis integrin alpha ps 0.0032 0.0117 0.0111
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0196 0.0392
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Schistosoma mansoni single-minded 0.0048 0.0216 0.0431
Onchocerca volvulus 0.0037 0.0146 0.0907
Leishmania major beta tubulin 0.0795 0.4937 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Leishmania major cysteine peptidase A (CPA) 0.0017 0.0017 0.0021
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0174 0.0345
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0146 0.0282
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0214
Mycobacterium tuberculosis Cell division protein FtsZ 0.0204 0.12 0.8894
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0109 0.0216
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.026 0.0522
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.0591 0.3651 0.7394
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.006 0.0122
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0022
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.0407 0.0818
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0273
Plasmodium vivax vivapain-2 0.0017 0.0017 0.0034
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Schistosoma mansoni alpha tubulin 0.0591 0.3651 0.7393
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Brugia malayi hypothetical protein 0.005 0.0226 0.0453
Trypanosoma cruzi tubulin gamma chain 0.0472 0.2894 0.5859
Toxoplasma gondii tubulin, putative 0.0026 0.0079 0.0152
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0226 0.0429
Onchocerca volvulus 0.0037 0.0146 0.0907
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0047 0.0207 0.1446
Trypanosoma cruzi zeta tubulin, putative 0.0479 0.2941 0.5953
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0299
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) hypothetical protein 0.0233 0.1388 0.2807
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0177 0.0345
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0017 0.0027
Echinococcus granulosus integrin alpha ps 0.0032 0.0117 0.0225
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.0407 0.0818
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Brugia malayi Tubulin alpha-2 chain 0.0591 0.3651 0.7394
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0023 0.0017
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0276 0.0552
Onchocerca volvulus 0.0055 0.026 0.1713
Leishmania major cathepsin L-like protease 0.0017 0.0017 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0196 0.019
Schistosoma mansoni DNA helicase recq1 0.0028 0.0091 0.0177
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0107 0.0204
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0407 0.0812
Echinococcus multilocularis tubulin alpha 1C chain 0.0591 0.3651 0.3647
Onchocerca volvulus 0.0048 0.0213 0.1382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.008 0.0149
Echinococcus multilocularis neuropeptide s receptor 0.0465 0.2852 0.2847
Onchocerca volvulus 0.0036 0.0137 0.0846
Leishmania major beta tubulin 0.0795 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.0407 0.082
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0204 0.12 0.2421
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0101 0.0549 0.11
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0091 0.0155
Plasmodium vivax glutathione reductase, putative 0.0047 0.0207 0.042
Treponema pallidum NADH oxidase 0.0016 0.0015 0.0094
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0196 0.0384
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0015 0.003
Loa Loa (eye worm) hypothetical protein 0.0118 0.0662 0.1335
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0109 0.0214
Trypanosoma cruzi epsilon tubulin, putative 0.0471 0.2892 0.5854
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0174 0.0345
Loa Loa (eye worm) hypothetical protein 0.0036 0.0137 0.0273
Echinococcus multilocularis neuropeptide receptor A26 0.0465 0.2852 0.2847
Schistosoma mansoni agrin 0.0038 0.015 0.0297
Trypanosoma brucei beta tubulin 0.0445 0.2726 0.5515
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0146 0.0907
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0177 0.0351
Brugia malayi Tubulin alpha-2 chain 0.0591 0.3651 0.7394
Onchocerca volvulus 0.0164 0.0947 0.6543
Trichomonas vaginalis conserved hypothetical protein 0.0204 0.12 0.2421
Schistosoma mansoni intermediate filament proteins 0.0027 0.0081 0.0157
Schistosoma mansoni cell adhesion molecule 0.0026 0.008 0.0155
Brugia malayi hypothetical protein 0.0023 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Trypanosoma brucei epsilon tubulin 0.0445 0.2726 0.5515
Plasmodium falciparum alpha tubulin 2 0.0591 0.3651 0.7387
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Onchocerca volvulus 0.0036 0.0137 0.0846
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.026 0.0522
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0053 0.0047
Brugia malayi nuclear receptor RXR 0.0041 0.0174 0.0347
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0253 0.1514 0.3062
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Leishmania major zeta tubulin, putative 0.0479 0.2941 0.5951
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0233
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1388 0.2801
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0269
Echinococcus multilocularis tubulin subunit TubB 0.0591 0.3651 0.3647
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.0407 0.0401
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0226 0.0451
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0207 0.0413
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0107 0.0217
Loa Loa (eye worm) hypothetical protein 0.0083 0.0439 0.0884
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0164 0.0947 0.1913
Loa Loa (eye worm) hypothetical protein 0.0083 0.0439 0.0884
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0065 0.0127
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0226 0.0451
Echinococcus multilocularis lamin dm0 0.0027 0.0081 0.0074
Schistosoma mansoni coup transcription factor 0.0078 0.0407 0.0818
Echinococcus multilocularis agrin 0.0038 0.015 0.0144
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0203 0.1254
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0177 0.0358
Loa Loa (eye worm) TK/ABL protein kinase 0.0216 0.1276 0.258
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.008 0.0149
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0155 0.0284
Schistosoma mansoni tyrosine kinase 0.0047 0.0212 0.0423
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.006 0.0343
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0029 0.0045
Trypanosoma brucei alpha tubulin 0.0591 0.3651 0.7392
Entamoeba histolytica cysteine protease, putative 0.0017 0.0017 0.0034
Echinococcus multilocularis integrin alpha ps 0.0068 0.034 0.0334
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0368 0.2241 0.4536
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0143 0.029
Plasmodium falciparum tubulin delta chain, putative 0.0204 0.12 0.2408
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0109 0.0707
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0119
Toxoplasma gondii beta-1 tubulin, putative 0.0795 0.4937 1
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0174 0.0347
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0137 0.0264
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Schistosoma mansoni hypothetical protein 0.0124 0.0698 0.1407
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0082
Schistosoma mansoni tyrosine kinase 0.0209 0.1234 0.2493
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Schistosoma mansoni lamin 0.0027 0.0081 0.0157
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0129 0.0248
Trichomonas vaginalis tubulin, putative 0.023 0.1369 0.2763
Brugia malayi nuclear receptor NHR-67 0.0037 0.0146 0.029
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0208
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0047 0.0212 0.0206
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.016
Loa Loa (eye worm) integrin alpha pat-2 0.0233 0.1383 0.2798
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Brugia malayi beta-lactamase family protein 0.0036 0.0137 0.0273
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.0407 0.082
Echinococcus granulosus GPCR family 2 0.0015 0.001 0.0008
Plasmodium falciparum tubulin gamma chain 0.0472 0.2894 0.585
Trypanosoma brucei tubulin gamma chain 0.0472 0.2894 0.5857
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.026 0.0522
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0177
Loa Loa (eye worm) BEN-1 protein 0.0795 0.4937 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.0407 0.2745
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0136 0.0268
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0324 0.0657
Echinococcus granulosus neuroglian 0.0024 0.0062 0.0112
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0193 0.0384
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0203 0.0399
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0137 0.0918
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.0407 0.0818
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0137 0.0131
Echinococcus multilocularis Tubulin beta 2C chain 0.0795 0.4937 0.4934
Echinococcus multilocularis integrin beta 2 0.0229 0.136 0.1355
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0015 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Mycobacterium ulcerans beta-lactamase 0.0036 0.0137 0.1032
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Echinococcus granulosus Tubulin beta 2C chain 0.0795 0.4937 1
Trichomonas vaginalis glucosylceramidase, putative 0.0175 0.102 0.2055
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.0407 0.0401
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0137 0.1032
Loa Loa (eye worm) beta-lactamase 0.0036 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Trichomonas vaginalis tubulin gamma chain, putative 0.0795 0.4937 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0193 0.0386
Loa Loa (eye worm) acetyltransferase 0.0142 0.0811 0.1638
Brugia malayi glutathione reductase 0.0047 0.0207 0.0415
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0225 0.045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0196 0.039
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0193 0.0186
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0127
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0137 0.1032
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0208
Mycobacterium ulcerans hypothetical protein 0.0023 0.006 0.0385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0017 0.0017 0.0021
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.018
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0146 0.0282
Trypanosoma brucei alpha tubulin, putative 0.0241 0.1438 0.2903
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0017 0.0017 0.0005
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0146 0.029
Echinococcus multilocularis Immunoglobulin 0.0021 0.0043 0.0037
Brugia malayi nuclear hormone receptor 0.0037 0.0146 0.029
Brugia malayi ecdysteroid receptor 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0179
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.006 0.0122
Brugia malayi beta-lactamase 0.0036 0.0137 0.0273
Trichomonas vaginalis tubulin beta chain, putative 0.0591 0.3651 0.7392
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.1591
Entamoeba histolytica tubulin alpha-1 chain 0.0591 0.3651 0.7395
Echinococcus granulosus cathepsin l1 0.0017 0.0017 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0094 0.0178
Echinococcus multilocularis tubulin alpha chain 0.0591 0.3651 0.3647
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0043 0.0037
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.0407 0.082
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0155 0.0284
Echinococcus multilocularis Tubulin beta 2C chain 0.0795 0.4937 0.4934
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0137 0.0131
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0226 0.0458
Leishmania major beta tubulin 0.0795 0.4937 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.027 0.0541
Echinococcus granulosus expressed conserved protein 0.0182 0.1063 0.2142
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0029
Trichomonas vaginalis tubulin beta chain, putative 0.0591 0.3651 0.7392
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0124 0.0246
Echinococcus multilocularis tubulin alpha chain 0.0591 0.3651 0.3647
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1514 0.3057
Schistosoma mansoni nuclear receptor 0.0037 0.0146 0.0288
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0021 0.0043 0.008
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0137 0.0273
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0324 0.0645
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0196 0.039
Echinococcus granulosus Tubulin beta 2C chain 0.0795 0.4937 1
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0006 0.0006
Plasmodium falciparum thioredoxin reductase 0.0047 0.0207 0.0392
Schistosoma mansoni tyrosine kinase 0.0019 0.003 0.0054
Schistosoma mansoni hypothetical protein 0.0333 0.202 0.4088
Plasmodium vivax tubulin alpha chain, putative 0.0591 0.3651 0.7395
Trichomonas vaginalis DNA helicase recq1, putative 0.0041 0.0169 0.033
Echinococcus multilocularis GPCR, family 2 0.0015 0.001 0.0004
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) alpha-tubulin 0.0591 0.3651 0.7394
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0221 0.0441
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0065 0.0132
Entamoeba histolytica protein kinase, putative 0.0034 0.0129 0.0261
Schistosoma mansoni cathepsin F (C01 family) 0.0017 0.0017 0.0027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0585 0.4282
Brugia malayi Cell division protein ftsZ 0.0204 0.12 0.2427
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0143 0.0277
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.015 0.0299
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0137 0.0918
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0216 0.1276 0.127
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0014 0.0021
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0196 0.0384
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0014 0.0022
Echinococcus granulosus Immunoglobulin 0.0021 0.0043 0.0074
Trichomonas vaginalis tubulin alpha chain, putative 0.0241 0.1438 0.2903
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0029
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0197 0.1156 0.2336
Entamoeba histolytica hypothetical protein 0.0071 0.036 0.0729
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0143 0.0261
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Loa Loa (eye worm) hypothetical protein 0.0102 0.0556 0.1122
Echinococcus granulosus agrin 0.0038 0.015 0.0291
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0065 0.0102
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0162 0.0936 0.1885
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0016
Brugia malayi Immunoglobulin I-set domain containing protein 0.0106 0.058 0.1171
Loa Loa (eye worm) transcription factor SMAD2 0.0235 0.1398 0.2827
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0137 0.0265
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0017 0.0017 0.0021
Echinococcus multilocularis tubulin gamma 1 chain 0.0472 0.2894 0.289
Leishmania major alpha tubulin 0.0591 0.3651 0.7392
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0006 0.0008
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0091 0.0085
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Schistosoma mansoni hypothetical protein 0.0404 0.2464 0.4988
Brugia malayi Cathepsin L-like precursor 0.0017 0.0017 0.0029
Echinococcus multilocularis tubulin subunit beta 0.0795 0.4937 0.4934
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0445 0.2726 0.5518
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0226 0.0451
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.027 0.0264
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0137 0.013
Plasmodium vivax tubulin beta chain, putative 0.0795 0.4937 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.006 0.0122
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Echinococcus multilocularis tubulin delta chain 0.0204 0.12 0.1195
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0146 0.029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0038 0.015 0.0299
Loa Loa (eye worm) alpha-tubulin 0.0591 0.3651 0.7394
Schistosoma mansoni hypothetical protein 0.0033 0.0124 0.0244
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Trichomonas vaginalis glucosylceramidase, putative 0.0253 0.1514 0.3057
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0146 0.0282
Schistosoma mansoni transcription factor LCR-F1 0.0071 0.036 0.0723
Trichomonas vaginalis tubulin, putative 0.0795 0.4937 1
Echinococcus multilocularis epidermal growth factor receptor 0.0298 0.1797 0.1792
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0146 0.029
Loa Loa (eye worm) hypothetical protein 0.0038 0.015 0.0299
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0324 0.0318
Giardia lamblia Beta tubulin 0.0795 0.4937 1
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0103 0.0562 0.1126
Trichomonas vaginalis glucosylceramidase, putative 0.0166 0.0963 0.194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0407 0.082
Giardia lamblia Gamma tubulin 0.0472 0.2894 0.585
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Trypanosoma cruzi alpha tubulin, putative 0.0591 0.3651 0.7393
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0193 0.0384
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0207 0.0408
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0146 0.0282
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0407 0.082
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0171 0.0165

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 3.4 uM Inhibition of ADP-induced platelet aggregation in human platelet rich plasma ChEMBL. 17500510
IC50 (functional) = 3.8 uM Inhibition of 5.0 ug/mL collagen-induced platelet aggregation in human platelet rich plasma ChEMBL. 17500510
IC50 (functional) = 13.7 uM Inhibition of A23187-induced platelet aggregation in human platelet rich plasma ChEMBL. 17500510

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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