Detailed information for compound 425770

Basic information

Technical information
  • TDR Targets ID: 425770
  • Name: 1-methyl-3-[(Z)-[1-(morpholin-4-ylmethyl)-5-n itro-2-oxoindol-3-ylidene]amino]thiourea
  • MW: 378.406 | Formula: C15H18N6O4S
  • H donors: 2 H acceptors: 3 LogP: 1.26 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNC(=S)N/N=C\1/c2cc(ccc2N(C1=O)CN1CCOCC1)[N+](=O)[O-]
  • InChi: 1S/C15H18N6O4S/c1-16-15(26)18-17-13-11-8-10(21(23)24)2-3-12(11)20(14(13)22)9-19-4-6-25-7-5-19/h2-3,8H,4-7,9H2,1H3,(H2,16,18,26)/b17-13-
  • InChiKey: NZYVTOAYVMMSGE-LGMDPLHJSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-methyl-3-[(Z)-[1-(morpholinomethyl)-5-nitro-2-oxo-indolin-3-ylidene]amino]thiourea
  • 1-methyl-3-[(Z)-[1-(morpholinomethyl)-5-nitro-2-oxo-3-indolinylidene]amino]thiourea
  • 1-methyl-3-[(Z)-[1-(morpholin-4-ylmethyl)-5-nitro-2-oxo-indol-3-ylidene]amino]thiourea
  • 1-[(Z)-[2-keto-1-(morpholinomethyl)-5-nitro-indolin-3-ylidene]amino]-3-methyl-thiourea
  • 1-[[2-keto-1-(morpholinomethyl)-5-nitro-indolin-3-ylidene]amino]-3-methyl-thiourea
  • 3-methyl-1-[[1-(morpholin-4-ylmethyl)-5-nitro-2-oxoindol-3-ylidene]amino]thiourea
  • 3-methyl-1-[[1-(morpholinomethyl)-5-nitro-2-oxo-indolin-3-ylidene]amino]thiourea
  • 3-methyl-1-[[1-(morpholinomethyl)-5-nitro-2-oxo-3-indolinylidene]amino]thiourea
  • 3-methyl-1-[[1-(morpholin-4-ylmethyl)-5-nitro-2-oxo-indol-3-ylidene]amino]thiourea
  • NCI60_040850
  • NSC718640

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0032 0.0115 0.0228
Echinococcus multilocularis tyrosine protein kinase Abl 0.0096 0.0522 0.0516
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0078 0.0407 0.0812
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0021
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.001 0.0004
Onchocerca volvulus 0.0026 0.0081 0.0449
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Echinococcus multilocularis agrin 0.0037 0.015 0.0144
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0041 0.0174 0.0167
Loa Loa (eye worm) hypothetical protein 0.0049 0.0221 0.0443
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0078 0.0407 0.0401
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.027 0.2157
Entamoeba histolytica hypothetical protein 0.0046 0.0203 0.0412
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Echinococcus granulosus FTZ F1 alpha 0.0078 0.0407 0.0812
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0143 0.0277
Echinococcus granulosus tubulin alpha 0.0443 0.2726 0.5515
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0014 0.0022
Brugia malayi Cell division protein ftsZ 0.0203 0.12 0.2427
Loa Loa (eye worm) acetyltransferase 0.0141 0.0811 0.1638
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0091 0.0155
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0203 0.12 0.2421
Onchocerca volvulus 0.0035 0.0137 0.0846
Loa Loa (eye worm) integrin beta-2 0.0308 0.1867 0.3777
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0155 0.0284
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Echinococcus multilocularis tubulin alpha chain 0.0588 0.3651 0.3647
Leishmania major hypothetical protein, conserved 0.0049 0.0226 0.0445
Echinococcus granulosus Tubulin alpha 1 chain 0.0588 0.3651 0.7392
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0274 0.0548
Echinococcus granulosus Tubulin alpha 1 chain 0.0588 0.3651 0.7392
Loa Loa (eye worm) hypothetical protein 0.0024 0.0062 0.012
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0081 0.0158
Brugia malayi Tubulin gamma chain 0.0469 0.2894 0.586
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0065 0.0102
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114 0.0634 0.128
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0193 0.0384
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0137 0.0673
Loa Loa (eye worm) Smad1 0.0016 0.0014 0.0022
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.031 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Mycobacterium leprae cell division protein FtsZ 0.0203 0.12 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0078 0.0407 0.0812
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0083 0.0438 0.0882
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0177 0.0351
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Brugia malayi conserved hypotetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) nuclear hormone receptor 0.0037 0.0146 0.029
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0137 0.1032
Echinococcus granulosus single minded 2 0.0035 0.0137 0.0265
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Mycobacterium ulcerans hypothetical protein 0.0023 0.006 0.0385
Schistosoma mansoni tubulin subunit delta 0.0203 0.12 0.2426
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.001 0.0008
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0024 0.0062 0.0119
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Mycobacterium leprae Probable lipase LipE 0.0035 0.0137 0.0673
Loa Loa (eye worm) hypothetical protein 0.0047 0.0209 0.0419
Echinococcus granulosus tubulin subunit beta 0.0791 0.4937 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0265
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1514 0.3057
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0015 0.0017
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0047 0.0212 0.0417
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0229 0.1366 0.2762
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0078 0.0407 0.082
Schistosoma mansoni thyroid hormone receptor 0.0201 0.1193 0.241
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0171 0.0334
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0143 0.0137
Trypanosoma brucei beta tubulin 0.0791 0.4937 1
Schistosoma mansoni tubulin subunit epsilon 0.0469 0.2892 0.5854
Leishmania major hypothetical protein, conserved 0.0035 0.0137 0.0265
Echinococcus multilocularis Tubulin beta 2C chain 0.0791 0.4937 0.4934
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0146 0.0907
Plasmodium falciparum tubulin beta chain 0.0791 0.4937 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Trypanosoma cruzi epsilon tubulin, putative 0.0469 0.2892 0.5854
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0017 0.0021
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Schistosoma mansoni DNA helicase recq5 0.0028 0.0091 0.0177
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.001
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0149
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Echinococcus granulosus tm gpcr rhodopsin 0.0519 0.3211 0.6498
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0124 0.0698 0.1402
Trypanosoma brucei alpha tubulin 0.0588 0.3651 0.7392
Leishmania major beta tubulin 0.0791 0.4937 1
Brugia malayi orphan nuclear receptor NR2E1 0.0037 0.0146 0.029
Leishmania major beta tubulin 0.0791 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0407 0.082
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0137 0.1032
Brugia malayi hypothetical protein 0.0023 0.0061 0.0118
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.006 0.0385
Trypanosoma brucei zeta tubulin 0.0477 0.2941 0.5951
Leishmania major beta tubulin 0.0791 0.4937 1
Entamoeba histolytica recQ family helicase, putative 0.0031 0.0107 0.0217
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Echinococcus multilocularis L aminoadipate semialdehyde 0.0163 0.0947 0.0941
Schistosoma mansoni alpha tubulin 0.0588 0.3651 0.7393
Giardia lamblia Delta tubulin 0.0203 0.12 0.2408
Toxoplasma gondii cathepsin CPL 0.0016 0.0017 0.0027
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0348 0.2126 0.4298
Echinococcus multilocularis epidermal growth factor receptor 0.0161 0.0936 0.093
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0177
Onchocerca volvulus 0.0035 0.0137 0.0846
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.001 0.0008
Schistosoma mansoni tubulin subunit beta 0.0791 0.4937 1
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0027
Echinococcus granulosus insulin receptor 0.0097 0.0531 0.1063
Brugia malayi Nuclear hormone receptor-like 1 0.0078 0.0407 0.082
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0015 0.003
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0046 0.0203 0.0405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Mycobacterium tuberculosis Probable reductase 0.0106 0.0585 0.4282
Echinococcus granulosus roundabout 2 0.0029 0.0098 0.0187
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Brugia malayi hypoxia-induced factor 1 0.0148 0.0852 0.1721
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0046 0.0203 1
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus granulosus histone acetyltransferase KAT2B 0.0137 0.0786 0.1581
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0078 0.0407 0.082
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0196 0.0384
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0137 0.0131
Schistosoma mansoni alpha tubulin 0.0588 0.3651 0.7393
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0065 0.0119
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0065 0.0378
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0207 0.0413
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0023 0.044
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0918
Brugia malayi alpha-tubulin 0.0588 0.3651 0.7394
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0081 0.0158
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0585 0.4282
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0269
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.027 0.0535
Trichomonas vaginalis tubulin epsilon chain, putative 0.0791 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0091 0.0155
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi Tubulin beta chain 0.0203 0.12 0.2427
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0023
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Schistosoma mansoni tyrosine kinase 0.0019 0.003 0.0054
Trichomonas vaginalis tubulin gamma chain, putative 0.0469 0.2894 0.5857
Loa Loa (eye worm) tubulin beta chain 0.0203 0.12 0.2427
Brugia malayi hypothetical protein 0.0047 0.0209 0.0419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0019 0.003 0.0024
Echinococcus multilocularis Niemann Pick C1 protein 0.0275 0.1663 0.1657
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0386 0.2363 0.478
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0121 0.0238
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Leishmania major beta tubulin 0.0791 0.4937 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0094 0.0178
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.027 0.0264
Brugia malayi Tyrosine-protein kinase abl-1 0.0125 0.0707 0.1428
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0047 0.0212 0.0206
Schistosoma mansoni hypothetical protein 0.0332 0.202 0.4088
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0137 0.0918
Leishmania major delta tubulin, putative 0.0367 0.2241 0.4532
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0171 0.0334
Onchocerca volvulus 0.0035 0.0137 0.0846
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) nuclear receptor NHR-67 0.0037 0.0146 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0078 0.0407 0.082
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0109 0.0216
Plasmodium vivax tubulin beta chain, putative 0.0791 0.4937 1
Echinococcus granulosus lamin 0.0026 0.0081 0.0151
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Schistosoma mansoni tubulin subunit beta 0.0791 0.4937 1
Echinococcus granulosus bloom syndrome protein 0.004 0.0169 0.033
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0107 0.0204
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0053 0.0095
Leishmania major beta tubulin 0.0791 0.4937 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni intermediate filament proteins 0.0026 0.0081 0.0157
Schistosoma mansoni tyrosine kinase 0.0097 0.0531 0.1069
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0196 0.0392
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0141 0.0811 0.1637
Onchocerca volvulus 0.0026 0.0081 0.0449
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0137 0.013
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0143 0.0137
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0006 0.0008
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0008
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0171 0.0165
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.0412
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0265
Echinococcus granulosus neuropeptide s receptor 0.0463 0.2852 0.5771
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0022
Trypanosoma brucei beta tubulin 0.0791 0.4937 1
Brugia malayi Steroid receptor seven-up type 2 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Plasmodium falciparum tubulin delta chain, putative 0.0203 0.12 0.2408
Echinococcus granulosus follistatin 0.0037 0.015 0.0291
Onchocerca volvulus 0.0163 0.0947 0.6543
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0155 0.0313
Loa Loa (eye worm) TK/EGFR protein kinase 0.0297 0.1797 0.3637
Trichomonas vaginalis tubulin alpha chain, putative 0.0791 0.4937 1
Trypanosoma brucei alpha tubulin, putative 0.024 0.1438 0.2903
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0137 0.0131
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Trypanosoma brucei zeta tubulin, putative 0.0477 0.2941 0.5951
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0225 0.045
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni follistatin 0.0037 0.015 0.0297
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0588 0.3651 0.7392
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0207 0.042
Echinococcus granulosus integrin alpha ps 0.0032 0.0117 0.0225
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0169 0.033
Brugia malayi Tubulin alpha-2 chain 0.0588 0.3651 0.7394
Trypanosoma brucei beta tubulin 0.0443 0.2726 0.5515
Toxoplasma gondii alpha-tubulin I, putative 0.0588 0.3651 0.7393
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0083 0.0438 0.0875
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Echinococcus granulosus sterol regulatory element binding protein 0.0083 0.0438 0.0875
Echinococcus multilocularis tumor protein p63 0.0332 0.2021 0.2016
Schistosoma mansoni zinc finger protein 0.0037 0.0146 0.0288
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Loa Loa (eye worm) cysteine protease 0.0016 0.0017 0.0029
Brugia malayi steroid hormone receptor 0.0078 0.0407 0.082
Brugia malayi Niemann-Pick C1 protein precursor 0.0193 0.1137 0.2299
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus granulosus integrin alpha 3 0.0115 0.0644 0.1293
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0078 0.0407 0.0401
Loa Loa (eye worm) hypothetical protein 0.0232 0.1388 0.2807
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0196 0.1156 0.2336
Trypanosoma brucei alpha tubulin 0.0588 0.3651 0.7392
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0055 0.026 0.0522
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Schistosoma mansoni tyrosine kinase 0.0156 0.0902 0.1821
Echinococcus multilocularis Tubulin beta 2C chain 0.0791 0.4937 0.4934
Schistosoma mansoni RAR-like nuclear receptor 0.0078 0.0407 0.0818
Echinococcus multilocularis tubulin alpha 3 chain 0.0588 0.3651 0.3647
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0661 0.4845
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0014 0.0015
Echinococcus granulosus alpha tubulin 0.0588 0.3651 0.7392
Trichomonas vaginalis DNA helicase recq, putative 0.0031 0.0107 0.0204
Echinococcus multilocularis Tubulin alpha 1 chain 0.0588 0.3651 0.3647
Schistosoma mansoni survival motor neuron protein 0.0047 0.0213 0.0425
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0585 0.4282
Echinococcus multilocularis Smad4 0.0016 0.0014 0.0007
Brugia malayi hypothetical protein 0.0055 0.026 0.0522
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0017 0.0034
Echinococcus granulosus tubulin alpha 3 chain 0.0588 0.3651 0.7392
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0017 0.0029
Schistosoma mansoni tyrosine kinase 0.0102 0.0562 0.1132
Loa Loa (eye worm) hypoxia-induced factor 1 0.0148 0.0852 0.1721
Entamoeba histolytica recQ family DNA helicase 0.0014 0.0003 0.0007
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.01 0.0549 0.0543
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0065 0.0102
Trypanosoma brucei epsilon tubulin 0.0469 0.2892 0.5852
Echinococcus granulosus tubulin alpha chain 0.0588 0.3651 0.7392
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0102 0.0562 0.0556
Onchocerca volvulus 0.0055 0.026 0.1713
Loa Loa (eye worm) alpha-tubulin 0.0588 0.3651 0.7394
Onchocerca volvulus Putative organic anion transporter 0.0055 0.026 0.1713
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.036 0.0354
Echinococcus multilocularis Tubulin beta 2C chain 0.0791 0.4937 0.4934
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0146 0.0139
Loa Loa (eye worm) TK protein kinase 0.0105 0.058 0.1171
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0179
Schistosoma mansoni tyrosine kinase 0.0156 0.0902 0.1821
Brugia malayi beta-tubulin, identical 0.0791 0.4937 1
Trichomonas vaginalis tubulin beta chain, putative 0.024 0.1438 0.2903
Brugia malayi beta-lactamase 0.0035 0.0137 0.0273
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0226 0.0429
Trichomonas vaginalis tubulin, putative 0.0229 0.1369 0.2763
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0137 0.0918
Echinococcus granulosus tyrosine kinase 0.0041 0.0171 0.0334
Schistosoma mansoni nuclear receptor nhr-48 0.0037 0.0146 0.0288
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0161 0.0936 0.1885
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0169 0.0338
Echinococcus multilocularis tubulin beta 1 chain 0.0791 0.4937 0.4934
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0078 0.0407 0.0812
Brugia malayi protein-tyrosine kinase 0.0041 0.0171 0.0341
Leishmania major beta tubulin 0.0791 0.4937 1
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0081 0.0158
Echinococcus multilocularis bloom syndrome protein 0.004 0.0169 0.0163
Plasmodium vivax tubulin epsilon chain, putative 0.0469 0.2892 0.5857
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0152 0.0295
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0078 0.0407 0.082
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0137 0.0918
Echinococcus granulosus Niemann Pick C1 protein 0.0193 0.1137 0.2293
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0102 0.0562 0.1126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0196 0.0384
Trypanosoma cruzi tubulin gamma chain 0.0469 0.2894 0.5859
Onchocerca volvulus Bile acid receptor homolog 0.0078 0.0407 0.2745
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.1514 0.3062
Entamoeba histolytica tubulin alpha-1 chain 0.0588 0.3651 0.7395
Echinococcus granulosus tubulin alpha 3 chain 0.0588 0.3651 0.7392
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0196 0.019
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Loa Loa (eye worm) ctsf protein 0.0016 0.0017 0.0029
Schistosoma mansoni tyrosine kinase 0.0019 0.003 0.0054
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0047 0.0209 0.0419
Schistosoma mansoni vesicular amine transporter 0.0021 0.0043 0.008
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0407 0.0401
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.0324 0.065
Brugia malayi nuclear receptor NHR-88 0.0078 0.0407 0.082
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0163 0.0947 0.1912
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) transcription factor SMAD2 0.0234 0.1398 0.2827
Onchocerca volvulus 0.0055 0.026 0.1713
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0177 0.0345
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0015 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0037 0.0146 0.0282
Brugia malayi hypothetical protein 0.0055 0.026 0.0522
Loa Loa (eye worm) tubulin beta-4 chain 0.0791 0.4937 1
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.001
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Leishmania major trypanothione reductase 0.0046 0.0207 0.0408
Brugia malayi Latrophilin receptor protein 2 0.0015 0.001 0.0016
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0207 0.1446
Schistosoma mansoni hypothetical protein 0.0102 0.0558 0.1124
Loa Loa (eye worm) tubulin beta-2A chain 0.0791 0.4937 1
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.027 0.0541
Echinococcus multilocularis smad 0.0016 0.0014 0.0007
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.006 0.0122
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0143 0.0277
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0791 0.4937 0.4934
Echinococcus multilocularis dnaJ subfamily B 0.0402 0.2464 0.246
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0143 0.0285
Plasmodium falciparum tubulin epsilon chain, putative 0.0469 0.2892 0.5845
Leishmania major beta tubulin 0.0791 0.4937 1
Schistosoma mansoni tubulin subunit beta 0.0791 0.4937 1
Echinococcus multilocularis tubulin gamma 1 chain 0.0469 0.2894 0.289
Echinococcus granulosus beta tubulin 0.0791 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.1306 0.2642
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.001 0.0016
Toxoplasma gondii tubulin, putative 0.0026 0.0079 0.0152
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Loa Loa (eye worm) TK protein kinase 0.0034 0.0129 0.0255
Loa Loa (eye worm) beta-lactamase 0.0035 0.0137 0.0273
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0151 0.0293
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0271
Echinococcus multilocularis tubulin alpha chain 0.0588 0.3651 0.3647
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0078 0.0407 0.0818
Brugia malayi intermediate filament protein 0.0026 0.0081 0.0158
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.0588 0.3651 0.7394
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.027 0.0535
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0193 0.0384
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0146 0.029
Echinococcus multilocularis tubulin epsilon chain 0.0469 0.2892 0.2887
Brugia malayi glutathione reductase 0.0046 0.0207 0.0415
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0046 0.0203 0.1591
Brugia malayi CHE-14 protein 0.0083 0.0438 0.0882
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0046 0.0203 0.0383
Trypanosoma cruzi epsilon tubulin, putative 0.0469 0.2892 0.5854
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.0324 0.0652
Entamoeba histolytica tubulin alpha chain, putative 0.0588 0.3651 0.7395
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0215 0.1276 0.127
Echinococcus granulosus ecdysone induced protein 78C 0.0078 0.0407 0.0812
Brugia malayi nuclear receptor NHR-67 0.0037 0.0146 0.029
Loa Loa (eye worm) TK/INSR protein kinase 0.0097 0.0531 0.1071
Trypanosoma cruzi MFS transporter, putative 0.0055 0.026 0.0521
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0324 0.065
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0203 0.12 1
Brugia malayi Furin-like cysteine rich region family protein 0.0297 0.1797 0.3637
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0002
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0124 0.0246
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0226 0.0451
Echinococcus multilocularis GPCR, family 2 0.0015 0.001 0.0004
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.0324 0.0657
Trichomonas vaginalis tubulin gamma chain, putative 0.0203 0.12 0.2421
Loa Loa (eye worm) hypothetical protein 0.0083 0.0439 0.0884
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0193 0.0378
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0226 0.0451
Schistosoma mansoni cell adhesion molecule 0.0026 0.008 0.0155
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Leishmania major beta tubulin 0.0791 0.4937 1
Schistosoma mansoni thyroid hormone receptor 0.0201 0.1193 0.241
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0265
Echinococcus granulosus tubulin beta 4A class IVa 0.0791 0.4937 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0137 0.0265
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0193 0.0384
Echinococcus multilocularis integrin alpha ps 0.0032 0.0117 0.0111
Toxoplasma gondii transporter, major facilitator family protein 0.0055 0.026 0.0521
Echinococcus granulosus thyroid hormone receptor alpha 0.0037 0.0146 0.0282
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0107 0.0204
Plasmodium vivax tubulin alpha chain, putative 0.0588 0.3651 0.7395
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0141 0.0811 0.0805
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.006 0.0343
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Trypanosoma cruzi tubulin delta chain 0.0367 0.2241 0.4536
Echinococcus granulosus Tubulin beta 2C chain 0.0791 0.4937 1
Trypanosoma cruzi zeta tubulin, putative 0.0477 0.2941 0.5953
Loa Loa (eye worm) tubulin gamma chain 0.0469 0.2894 0.586
Trypanosoma brucei tubulin delta chain 0.0367 0.2241 0.4532
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0065 0.0059
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0027
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis tubulin subunit TubB 0.0588 0.3651 0.3647
Plasmodium vivax tubulin gamma chain, putative 0.0469 0.2894 0.5862
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.1591
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0083 0.0439 0.0884
Echinococcus multilocularis c src tyrosine kinase 0.0019 0.003 0.0024
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0283
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0065 0.0133
Echinococcus multilocularis Tubulin alpha 1 chain 0.0588 0.3651 0.3647
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0017 0.0021
Leishmania major beta tubulin 0.0791 0.4937 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0196 0.019
Echinococcus multilocularis FTZ F1 alpha 0.0078 0.0407 0.0401
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1514 0.3057
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0158
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Trichomonas vaginalis tubulin alpha chain, putative 0.024 0.1438 0.2903
Brugia malayi Smad1 0.0016 0.0014 0.0022
Echinococcus granulosus tubulin alpha 1C chain 0.0588 0.3651 0.7392
Schistosoma mansoni hypothetical protein 0.0402 0.2464 0.4988
Onchocerca volvulus 0.0035 0.0137 0.0846
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0037 0.0146 0.0139
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0037 0.0146 0.0907
Schistosoma mansoni nuclear receptor 0.0037 0.0146 0.0288
Loa Loa (eye worm) tubulin alpha 2 0.0386 0.2363 0.4784
Echinococcus granulosus Solute carrier organic anion transporter family 0.0055 0.026 0.0515
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Plasmodium falciparum thioredoxin reductase 0.0046 0.0207 0.0392
Loa Loa (eye worm) TK/ABL protein kinase 0.0215 0.1276 0.258
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0017 0.0005
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0171 0.0165
Giardia lamblia Epsilon tubulin 0.0229 0.1366 0.2746
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0407 0.082
Trypanosoma brucei beta tubulin 0.0791 0.4937 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0078 0.0407 0.082
Echinococcus granulosus dnaJ subfamily B 0.0402 0.2464 0.4985
Plasmodium vivax glutathione reductase, putative 0.0046 0.0207 0.042
Echinococcus granulosus tubulin subunit TubB 0.0588 0.3651 0.7392
Echinococcus multilocularis epidermal growth factor receptor 0.0297 0.1797 0.1792
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0091 0.0179
Toxoplasma gondii thioredoxin reductase 0.0046 0.0207 0.0413
Echinococcus multilocularis neuroglian 0.0023 0.0062 0.0055
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0119
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Schistosoma mansoni hypothetical protein 0.0124 0.0698 0.1407
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Loa Loa (eye worm) tubulin alpha 2 0.0146 0.0838 0.1693
Brugia malayi Fibronectin type III domain containing protein 0.0023 0.0061 0.0118
Plasmodium vivax tubulin alpha chain, putative 0.0588 0.3651 0.7395
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0193 0.0391
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Brugia malayi tubulin alpha chain - mouse 0.0588 0.3651 0.7394
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0324 0.0645
Toxoplasma gondii protease inhibitor PI2 0.0037 0.015 0.0297
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0136 0.0268
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.1514 0.3062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0407 0.0812
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0014 0.0022
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0078 0.0407 0.0812
Echinococcus multilocularis expressed protein 0.0037 0.015 0.0144
Mycobacterium ulcerans cell division protein FtsZ 0.0203 0.12 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0137 0.0918
Trichomonas vaginalis tubulin, putative 0.0791 0.4937 1
Echinococcus multilocularis tubulin alpha 1C chain 0.0588 0.3651 0.3647
Brugia malayi Immunoglobulin I-set domain containing protein 0.0105 0.058 0.1171
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.001 0.0004
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0037 0.0146 0.0139
Echinococcus multilocularis tubulin alpha 0.0443 0.2726 0.2721
Toxoplasma gondii beta-1 tubulin, putative 0.0791 0.4937 1
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0193 0.1137 0.2303
Echinococcus multilocularis integrin beta 2 0.0228 0.136 0.1355
Brugia malayi nuclear hormone receptor 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Echinococcus granulosus defective proboscis extension response 0.0021 0.0043 0.0074
Schistosoma mansoni tubulin subunit beta 0.0791 0.4937 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0137 0.0918
Entamoeba histolytica cysteine protease, putative 0.0016 0.0017 0.0034
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0046 0.0203 0.0405
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.006 0.0385
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0082
Echinococcus multilocularis insulin receptor 0.0097 0.0531 0.0525
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0109 0.0214
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Giardia lamblia Alpha-tubulin 0.0588 0.3651 0.7387
Onchocerca volvulus Putative organic anion transporter 0.0055 0.026 0.1713
Trichomonas vaginalis tubulin epsilon chain, putative 0.0588 0.3651 0.7392
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0265
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0082
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0015 0.0017
Onchocerca volvulus 0.0055 0.026 0.1713
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus granulosus intermediate filament protein 0.0026 0.0081 0.0151
Loa Loa (eye worm) BEN-1 protein 0.0791 0.4937 1
Toxoplasma gondii ABC1 family protein 0.0035 0.0137 0.0271
Onchocerca volvulus 0.0037 0.0146 0.0907
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.0324 0.0645
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0214
Echinococcus granulosus c src tyrosine kinase 0.0019 0.003 0.0048
Echinococcus granulosus L aminoadipate semialdehyde 0.0163 0.0947 0.1907
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0146 0.0288
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Leishmania major phosphopantetheinyl transferase-like protein 0.0046 0.0203 0.0399
Brugia malayi Tubulin alpha chain 0.0203 0.12 0.2427
Schistosoma mansoni integrin alpha 0.015 0.0867 0.1749
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0014 0.0021
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Trypanosoma cruzi cruzipain precursor, putative 0.0063 0.031 0.0622
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0265
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0214
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0143 0.0283
Schistosoma mansoni tubulin subunit alpha 0.0203 0.12 0.2426
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.12 0.2421
Onchocerca volvulus 0.0037 0.015 0.0936
Leishmania major beta tubulin 0.0791 0.4937 1
Schistosoma mansoni transcription factor LCR-F1 0.007 0.036 0.0723
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0061 0.0118
Onchocerca volvulus 0.0049 0.0221 0.1436
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Onchocerca volvulus 0.024 0.1438 1
Brugia malayi hypothetical protein 0.0049 0.0226 0.0453
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0015 0.0023
Brugia malayi Tubulin beta chain 0.024 0.1438 0.2909
Schistosoma mansoni nuclear hormone receptor 0.0037 0.0146 0.0288
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.018
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0193 0.0378
Echinococcus multilocularis thyroid hormone receptor alpha 0.0201 0.1193 0.1187
Echinococcus granulosus neuropeptide receptor A26 0.0463 0.2852 0.5771
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.001
Leishmania major beta tubulin 0.0791 0.4937 1
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0221 0.0441
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0047 0.0212 0.0206
Echinococcus granulosus cpg binding protein 0.003 0.0102 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1514 0.3057
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0191
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.0021 0.0043 0.008
Echinococcus multilocularis tubulin alpha chain 0.0588 0.3651 0.3647
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0047 0.0212 0.0206
Schistosoma mansoni hypothetical protein 0.0033 0.0124 0.0244
Brugia malayi nuclear hormone receptor 0.0037 0.0146 0.029
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0015 0.0017
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0193 0.0378
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0918
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0231
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0299
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0149
Brugia malayi nuclear receptor NHR-88 0.0037 0.0146 0.029
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0137 0.0264
Schistosoma mansoni nephrin 0.0026 0.008 0.0154
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.0179
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0146 0.0282
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0078
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.006 0.0385
Brugia malayi hypothetical protein 0.0037 0.0146 0.029
Echinococcus granulosus tyrosine protein kinase Src64B 0.0047 0.0212 0.0417
Mycobacterium leprae conserved hypothetical protein 0.0046 0.0203 0.1254
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0207 0.0415
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0226 0.0429
Trypanosoma cruzi beta tubulin, putative 0.0791 0.4937 1
Brugia malayi isocitrate dehydrogenase 0.0031 0.0109 0.0216
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0177 0.0351
Echinococcus multilocularis Tubulin alpha 1 chain 0.0588 0.3651 0.3647
Trichomonas vaginalis tubulin, putative 0.024 0.1438 0.2903
Schistosoma mansoni Neurotrimin precursor (hNT) 0.0021 0.0043 0.008
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0065 0.0119
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0212 0.0417
Onchocerca volvulus 0.0023 0.006 0.0306
Brugia malayi ecdysone receptor 0.0037 0.0146 0.029
Loa Loa (eye worm) tubulin beta-1 chain 0.0791 0.4937 1
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.0324 0.0318
Echinococcus multilocularis expressed conserved protein 0.0181 0.1063 0.1057
Brugia malayi Nuclear hormone receptor E75 0.0037 0.0146 0.029
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0155 0.0284
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Leishmania major beta tubulin 0.0791 0.4937 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0407 0.082
Echinococcus granulosus cathepsin l1 0.0016 0.0017 0.0021
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.031 0.0622
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.006 0.0122
Toxoplasma gondii beta-tubulin, putative 0.0791 0.4937 1
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Trichomonas vaginalis tubulin epsilon chain, putative 0.0588 0.3651 0.7392
Trypanosoma brucei trypanothione reductase 0.0046 0.0207 0.0408
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Echinococcus multilocularis follistatin 0.0037 0.015 0.0144
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0143 0.0137
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Trichomonas vaginalis tubulin epsilon chain, putative 0.0791 0.4937 1
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0014 0.0007
Leishmania major epsilon tubulin, putative 0.0469 0.2892 0.5852
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0078 0.0407 0.0818
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0246 0.0494
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0102 0.0562 0.0556
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0078 0.0407 0.082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.006 0.0343
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.024 0.1438 0.2903
Loa Loa (eye worm) beta-tubulin 0.0791 0.4937 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0143 0.0261
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0273
Trichomonas vaginalis tubulin, putative 0.024 0.1438 0.2903
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Onchocerca volvulus 0.0055 0.026 0.1713
Echinococcus multilocularis Tubulin beta 2C chain 0.0791 0.4937 0.4934
Schistosoma mansoni integrin alpha-ps 0.0067 0.034 0.0682
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0065 0.0059
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0143 0.0283
Trichomonas vaginalis tubulin beta chain, putative 0.0588 0.3651 0.7392
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.015 0.0299
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.102 0.2055
Echinococcus granulosus tubulin alpha chain 0.0588 0.3651 0.7392
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0055 0.026 0.0254
Leishmania major beta tubulin 0.0791 0.4937 1
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Mycobacterium ulcerans beta-lactamase 0.0035 0.0137 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Leishmania major cathepsin L-like protease 0.0063 0.031 0.0617
Schistosoma mansoni organic anion transporter 0.0055 0.026 0.0521
Brugia malayi hypothetical protein 0.007 0.036 0.0724
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0014
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.027 0.1918
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1514 0.3057
Schistosoma mansoni single-minded 0.0048 0.0216 0.0431
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0078 0.0407 0.0818
Loa Loa (eye worm) hypothetical protein 0.0021 0.0043 0.0082
Trichomonas vaginalis tubulin epsilon chain, putative 0.0203 0.12 0.2421
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0196 0.039
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Echinococcus multilocularis Niemann Pick C1 protein 0.0193 0.1137 0.1131
Loa Loa (eye worm) tubulin alpha-3 chain 0.0348 0.2126 0.4302
Echinococcus granulosus Tubulin beta 2C chain 0.0791 0.4937 1
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0055 0.026 0.0254
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0208
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Echinococcus granulosus Smad4 0.0016 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Loa Loa (eye worm) hypothetical protein 0.0101 0.0556 0.1122
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0143 0.0277
Echinococcus granulosus lamin dm0 0.0026 0.0081 0.0151
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0019 0.003 0.0048
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0091 0.0085
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0015 0.0017
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0065 0.0119
Echinococcus multilocularis neuropeptide s receptor 0.0463 0.2852 0.2847
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0078 0.0407 0.082
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0021
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0065 0.0132
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0078 0.0407 0.082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis roundabout 2 0.0029 0.0098 0.0092
Giardia lamblia Beta tubulin 0.0791 0.4937 1
Schistosoma mansoni tyrosine kinase 0.0156 0.0902 0.1821
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0078 0.0407 0.0818
Brugia malayi acetyltransferase, GNAT family protein 0.0141 0.0811 0.1638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0078 0.0407 0.0812
Loa Loa (eye worm) RecQ helicase 0.004 0.0169 0.0338
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0083 0.0438 0.0882
Loa Loa (eye worm) tubulin alpha chain 0.0588 0.3651 0.7394
Echinococcus granulosus Tubulin alpha 1 chain 0.0588 0.3651 0.7392
Schistosoma mansoni integrin beta subunit 0.0181 0.1063 0.2148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Trichomonas vaginalis esterase, putative 0.0035 0.0137 0.0265
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0065 0.0119
Echinococcus granulosus tubulin beta 1 chain 0.0791 0.4937 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0078 0.0407 0.082
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0143 0.029
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0017 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0046 0.0203 0.1415
Brugia malayi prostaglandin transporter 0.0055 0.026 0.0522
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0199
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0023 0.0046
Echinococcus multilocularis hypothetical protein 0.0588 0.3651 0.3647
Schistosoma mansoni hypothetical protein 0.008 0.0419 0.0842
Trypanosoma cruzi tubulin delta chain 0.0367 0.2241 0.4536
Echinococcus multilocularis Immunoglobulin 0.0021 0.0043 0.0037
Schistosoma mansoni nuclear receptor 0.0037 0.0146 0.0288
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1388 0.2801
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Schistosoma mansoni alpha tubulin 0.0588 0.3651 0.7393
Echinococcus granulosus insulin growth factor 1 receptor beta 0.01 0.0549 0.11
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0293 0.0586
Schistosoma mansoni tubulin subunit beta 0.0791 0.4937 1
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.026 0.0522
Leishmania major beta tubulin 0.0791 0.4937 1
Schistosoma mansoni tubulin subunit alpha 0.0588 0.3651 0.7393
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0047 0.0212 0.0417
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.006 0.0122
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0193 0.0186
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0078 0.0407 0.082
Brugia malayi hypothetical protein 0.0037 0.0146 0.029
Brugia malayi Protein kinase domain containing protein 0.0097 0.0531 0.1071
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0047 0.0212 0.0206
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Leishmania major cathepsin L-like protease 0.0063 0.031 0.0617
Echinococcus multilocularis tubulin delta chain 0.0203 0.12 0.1195
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0024 0.0062 0.0113
Loa Loa (eye worm) hypothetical protein 0.0118 0.0662 0.1335
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Onchocerca volvulus Putative organic anion transporter 0.0055 0.026 0.1713
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0137 0.0273
Echinococcus granulosus agrin 0.0037 0.015 0.0291
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0196 0.039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0271
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0037 0.0146 0.029
Brugia malayi hypothetical protein 0.0041 0.0174 0.0347
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0078 0.0407 0.0818
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0277
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0078 0.0407 0.082
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Entamoeba histolytica tubulin gamma chain 0.0469 0.2894 0.5862
Echinococcus granulosus Niemann Pick C1 protein 0.0275 0.1663 0.3359
Echinococcus granulosus epidermal growth factor receptor 0.0297 0.1797 0.3632
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0091 0.0085
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni tyrosine kinase 0.0208 0.1234 0.2493
Echinococcus multilocularis tubulin subunit beta 0.0791 0.4937 0.4934
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0078 0.0407 0.082
Echinococcus granulosus tubulin alpha chain 0.0588 0.3651 0.7392
Brugia malayi hypothetical protein 0.0219 0.1306 0.2642
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0137 0.0265
Echinococcus multilocularis integrin alpha ps 0.0067 0.034 0.0334
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Brugia malayi hypothetical protein 0.016 0.0931 0.1881
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0137 0.0278
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus multilocularis nuclear receptor nhr 48 0.0037 0.0146 0.0139
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0367 0.2241 0.4536
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.0212 0.0206
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0015 0.003
Schistosoma mansoni tyrosine kinase 0.0097 0.0531 0.1069
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0137 0.0918
Brugia malayi Integrin beta pat-3 precursor 0.0308 0.1867 0.3777
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0214
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0151 0.0144
Echinococcus granulosus Tubulin beta 2C chain 0.0791 0.4937 1
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0065 0.0125
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0226 0.0451
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0196 0.039
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0199
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0109 0.0214
Schistosoma mansoni coup transcription factor 0.0078 0.0407 0.0818
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0124 0.0698 0.0692
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0078 0.0407 0.082
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.0324 0.065
Echinococcus multilocularis tubulin alpha chain 0.0588 0.3651 0.3647
Trichomonas vaginalis tubulin alpha chain, putative 0.0443 0.2726 0.5515
Giardia lamblia GTOR 0.0044 0.0193 0.0362
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0037 0.0146 0.0282
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0585 0.4606
Plasmodium falciparum alpha tubulin 2 0.0588 0.3651 0.7387
Echinococcus granulosus peroxisome assembly protein 26 0.0588 0.3651 0.7392
Loa Loa (eye worm) SRC-1 0.0047 0.0212 0.0425
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0153 0.0281
Echinococcus granulosus epidermal growth factor receptor 0.0161 0.0936 0.1885
Echinococcus granulosus geminin 0.0332 0.202 0.4084
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0078 0.0407 0.0401
Schistosoma mansoni steroid hormone receptor ad4bp 0.0078 0.0407 0.0818
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0207 0.0201
Echinococcus granulosus Tubulin beta 2C chain 0.0791 0.4937 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.006 0.0385
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.027 0.2157
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0271
Entamoeba histolytica tubulin family protein 0.0791 0.4937 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0143 0.0277
Brugia malayi hypothetical protein 0.0041 0.0174 0.0347
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1514 0.3057
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0208
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0174 0.0347
Echinococcus granulosus Nuclear hormone receptor HR96 0.0037 0.0146 0.0282
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Plasmodium falciparum glutathione reductase 0.0046 0.0207 0.0392
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0023 0.007
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0017 0.0021
Schistosoma mansoni tyrosine kinase 0.0161 0.0936 0.189
Loa Loa (eye worm) tubulin alpha-2 chain 0.0588 0.3651 0.7394
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0246
Entamoeba histolytica tubulin family protein 0.0791 0.4937 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0196 0.0392
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0109 0.0208
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0585 0.4282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus granulosus tubulin alpha 1C chain 0.0588 0.3651 0.7392
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0017 0.0021
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Leishmania major gamma-tubulin 0.0469 0.2894 0.5857
Echinococcus multilocularis Tubulin beta 2C chain 0.0791 0.4937 0.4934
Schistosoma mansoni organic anion transporter 0.0055 0.026 0.0521
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0037 0.0146 0.0288
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0053 0.0047
Schistosoma mansoni nuclear hormone receptor 0.0078 0.0407 0.0818
Trichomonas vaginalis tubulin beta chain, putative 0.0588 0.3651 0.7392
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0096 0.019
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0519 0.3211 0.3206
Onchocerca volvulus 0.0055 0.026 0.1713
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0109 0.0707
Echinococcus granulosus GPCR family 2 0.0015 0.001 0.0008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Loa Loa (eye worm) hypothetical protein 0.0041 0.0174 0.0347
Plasmodium vivax vivapain-2 0.0016 0.0017 0.0034
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0193 0.0386
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0006 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Echinococcus multilocularis 0.0091 0.0488 0.0482
Loa Loa (eye worm) alpha-tubulin 0.0588 0.3651 0.7394
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0023 0.0062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.036 0.0717
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Giardia lamblia Gamma tubulin 0.0469 0.2894 0.585
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0055 0.026 0.0515
Trypanosoma brucei hypothetical protein, conserved 0.0046 0.0203 0.0399
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0015 0.0025
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0283
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0171 0.0165
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.027 0.0543
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.0216 0.0431
Loa Loa (eye worm) TK protein kinase 0.0041 0.0171 0.0341
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Schistosoma mansoni smad 0.0016 0.0014 0.0021
Echinococcus granulosus beta tubulin 0.0791 0.4937 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0146
Echinococcus granulosus smad 0.0016 0.0014 0.0015
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0016
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Echinococcus multilocularis Immunoglobulin 0.0021 0.0043 0.0037
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0129 0.0122
Echinococcus multilocularis lamin dm0 0.0026 0.0081 0.0074
Schistosoma mansoni tubulin subunit gamma 0.0469 0.2894 0.5859
Echinococcus granulosus tumor protein p63 0.0332 0.2021 0.4085
Mycobacterium ulcerans lipase LipD 0.0035 0.0137 0.1032
Mycobacterium tuberculosis Cell division protein FtsZ 0.0203 0.12 0.8894
Loa Loa (eye worm) hypothetical protein 0.0348 0.2126 0.4302
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0213 0.0427
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0015 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus multilocularis tubulin alpha chain 0.0588 0.3651 0.3647
Echinococcus granulosus tubulin epsilon chain 0.0469 0.2892 0.5852
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.026 0.0522
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Trypanosoma cruzi alpha tubulin, putative 0.0588 0.3651 0.7393
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0137 0.0918
Brugia malayi Tyrosine-protein kinase abl-1 0.0096 0.0522 0.1053
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0078 0.0407 0.0401
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Schistosoma mansoni tubulin subunit alpha 0.0588 0.3651 0.7393
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0276 0.0552
Echinococcus granulosus nuclear receptor nhr 48 0.0037 0.0146 0.0282
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0137 0.0273
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0017 0.0005
Echinococcus granulosus tyrosine protein kinase ABL1 0.0215 0.1276 0.2574
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Plasmodium falciparum alpha tubulin 1 0.0588 0.3651 0.7387
Loa Loa (eye worm) steroid hormone receptor 0.0078 0.0407 0.082
Echinococcus multilocularis neuropeptide receptor A26 0.0463 0.2852 0.2847
Schistosoma mansoni tubulin subunit beta 0.0791 0.4937 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0015 0.0023
Trypanosoma cruzi zeta tubulin, putative 0.0477 0.2941 0.5953
Trypanosoma brucei epsilon tubulin 0.0469 0.2892 0.5852
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.12 0.2421
Echinococcus multilocularis musashi 0.0026 0.0081 0.0074
Loa Loa (eye worm) MH2 domain-containing protein 0.0234 0.1398 0.2827
Schistosoma mansoni tyrosine kinase 0.0297 0.1797 0.3635
Trypanosoma brucei tubulin gamma chain 0.0469 0.2894 0.5857
Echinococcus multilocularis ecdysone induced protein 78C 0.0078 0.0407 0.0401
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0285
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0125
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0065 0.0127
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.1591
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0177 0.0358
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0222 0.0444
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Brugia malayi nuclear receptor RXR 0.0041 0.0174 0.0347
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Brugia malayi Tubulin alpha-2 chain 0.0588 0.3651 0.7394
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0386 0.2363 0.4784
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0443 0.2726 0.5518
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0169 0.033
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0091 0.0172
Echinococcus multilocularis beta tubulin 0.0791 0.4937 0.4934
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0017 0.0029
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0386 0.2363 0.4784
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0078 0.0407 0.2745
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0207 0.0408
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0193 0.0378
Loa Loa (eye worm) BEN-1 protein 0.0791 0.4937 1
Echinococcus granulosus integrin beta 2 0.0228 0.136 0.2745
Brugia malayi sulfakinin receptor protein 0.0219 0.1306 0.2642
Echinococcus granulosus fibroblast growth factor receptor 4 0.0102 0.0562 0.1126
Brugia malayi nuclear hormone receptor family member odr-7 0.0037 0.0146 0.029
Trypanosoma brucei alpha tubulin 0.0588 0.3651 0.7392
Echinococcus multilocularis integrin alpha ps 0.0067 0.034 0.0334
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0017 0.0034
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.0324 0.0645
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0177 0.0345
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0273
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0158
Echinococcus granulosus Immunoglobulin 0.0021 0.0043 0.0074
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0022
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.001 0.0016
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0078 0.0151
Trypanosoma brucei beta tubulin 0.0791 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Trichomonas vaginalis tubulin gamma chain, putative 0.0469 0.2892 0.5852
Treponema pallidum NADH oxidase 0.0016 0.0015 0.0094
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0031 0.0107 0.021
Leishmania major cathepsin L-like protease 0.0063 0.031 0.0617
Trichomonas vaginalis tubulin beta chain, putative 0.0791 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Brugia malayi SRC-1 0.0047 0.0212 0.0425
Treponema pallidum cell division protein FtsZ 0.0203 0.12 1
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0021
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Loa Loa (eye worm) hypothetical protein 0.016 0.0931 0.1881
Trichomonas vaginalis tubulin beta chain, putative 0.0588 0.3651 0.7392
Onchocerca volvulus Protein ultraspiracle homolog 0.0078 0.0407 0.2745
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0193 0.0386
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0193 0.1137 0.2299
Trypanosoma brucei epsilon tubulin 0.0443 0.2726 0.5515
Trichomonas vaginalis tubulin beta chain, putative 0.0588 0.3651 0.7392
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0177
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0014 0.0015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Loa Loa (eye worm) DR-78 0.0037 0.0146 0.029
Leishmania major beta tubulin 0.0791 0.4937 1
Mycobacterium ulcerans hypothetical protein 0.0035 0.0137 0.1032
Schistosoma mansoni hypothetical protein 0.0332 0.202 0.4088
Loa Loa (eye worm) hypothetical protein 0.0037 0.0146 0.029
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0222 0.0444
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0017
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0065 0.0125
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0109 0.0221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Brugia malayi Tubulin beta-1 chain 0.0791 0.4937 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0146
Loa Loa (eye worm) hypothetical protein 0.0163 0.0947 0.1913
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0037 0.0146 0.0288
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.0963 0.6658
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0661 0.5265
Echinococcus multilocularis lamin 0.0026 0.0081 0.0074
Brugia malayi Integrin alpha pat-2 precursor 0.015 0.0867 0.1751
Echinococcus granulosus neuroglian 0.0023 0.0062 0.0112
Echinococcus granulosus expressed conserved protein 0.0181 0.1063 0.2142
Leishmania major beta tubulin 0.0791 0.4937 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0078 0.0407 0.082
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.1348 1
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0046 0.0203 0.167
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0585 0.4282
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0029 0.0045
Schistosoma mansoni DNA helicase recq1 0.0028 0.0091 0.0177
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.0212 0.0417
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0158
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0041 0.0174 0.0339
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Echinococcus granulosus tubulin delta chain 0.0203 0.12 0.2421
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0065 0.0514
Echinococcus multilocularis integrin alpha 3 0.0115 0.0644 0.0638
Schistosoma mansoni hypothetical protein 0.007 0.036 0.0723
Schistosoma mansoni tubulin subunit alpha 0.0588 0.3651 0.7393
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0137 0.1032
Loa Loa (eye worm) integrin alpha pat-2 0.0231 0.1383 0.2798
Trypanosoma cruzi cysteine peptidase, putative 0.0063 0.031 0.0622
Plasmodium vivax delta tubulin, putative 0.0203 0.12 0.2431
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0109 0.0103
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0585 0.4282
Loa Loa (eye worm) hypothetical protein 0.0049 0.0226 0.0453
Trichomonas vaginalis tubulin alpha chain, putative 0.024 0.1438 0.2903
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0918
Schistosoma mansoni lamin 0.0026 0.0081 0.0157
Loa Loa (eye worm) tubulin alpha 2 0.0386 0.2363 0.4784
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0143 0.0277
Echinococcus multilocularis tubulin alpha 1C chain 0.0588 0.3651 0.3647
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0661 0.4845
Entamoeba histolytica protein kinase, putative 0.0034 0.0129 0.0261
Echinococcus multilocularis cpg binding protein 0.003 0.0102 0.0095
Leishmania major beta tubulin 0.0791 0.4937 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0083 0.0438 0.0432
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0179
Echinococcus granulosus tubulin gamma 1 chain 0.0469 0.2894 0.5857
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0023 0.0017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Brugia malayi sodium-independent organic anion transporter family protein 0.0055 0.026 0.0522
Trichomonas vaginalis tubulin beta chain, putative 0.0588 0.3651 0.7392
Brugia malayi tailless protein 0.0037 0.0146 0.029
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0041 0.0174 0.0345
Loa Loa (eye worm) glutathione reductase 0.0046 0.0207 0.0415
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0047 0.0212 0.0206
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0091 0.0172
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.102 0.2055
Loa Loa (eye worm) tubulin beta chain 0.0791 0.4937 1
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.1514 0.3057
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0109 0.0192
Brugia malayi Nuclear hormone receptor-like 1 0.0041 0.0174 0.0347
Brugia malayi hypothetical protein 0.0232 0.1388 0.2807
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0041 0.0174 0.0347
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0037 0.0146 0.0139
Leishmania major beta tubulin 0.0791 0.4937 1
Echinococcus multilocularis geminin 0.0332 0.202 0.2015
Brugia malayi Thioredoxin reductase 0.0046 0.0207 0.0415
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0134 0.0761 0.0755
Echinococcus granulosus tubulin alpha chain 0.0588 0.3651 0.7392
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0078 0.0407 0.082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Echinococcus granulosus Protein patched homolog 1 0.0083 0.0438 0.0875
Brugia malayi tubulin alpha-2 chain 0.0588 0.3651 0.7394
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1388 0.1382
Schistosoma mansoni lamin 0.0026 0.0081 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0149
Echinococcus granulosus tubulin alpha chain 0.0588 0.3651 0.7392
Echinococcus granulosus Tubulin beta 2C chain 0.0791 0.4937 1
Trypanosoma brucei alpha tubulin 0.0588 0.3651 0.7392
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.0963 0.194
Onchocerca volvulus 0.0028 0.0092 0.0526
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0063 0.031 0.0617
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0129 0.0248
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0014 0.0007
Schistosoma mansoni patched 1 0.0083 0.0438 0.0881
Echinococcus multilocularis protein patched 0.0083 0.0438 0.0432
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0175 0.1022 0.206
Toxoplasma gondii alpha tubulin TUBA1 0.0588 0.3651 0.7393
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0078 0.0407 0.082
Loa Loa (eye worm) hypothetical protein 0.0078 0.0407 0.082
Schistosoma mansoni hypothetical protein 0.0047 0.0213 0.0425
Giardia lamblia Beta tubulin 0.0791 0.4937 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0109 0.0103
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0037 0.0146 0.029
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0029 0.0096 0.019
Echinococcus multilocularis peroxisome assembly protein 26 0.0588 0.3651 0.3647
Loa Loa (eye worm) hypothetical protein 0.0055 0.026 0.0522
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Onchocerca volvulus 0.0037 0.0146 0.0907
Schistosoma mansoni integrin alpha-ps 0.0035 0.0135 0.0267
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0022
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0143 0.0277
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0177 0.0345
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0136 0.0262
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0078 0.0407 0.0818
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0101
Echinococcus multilocularis basement membrane specific heparan sulfate 0.0021 0.0043 0.0037
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0226 0.0458
Plasmodium falciparum tubulin gamma chain 0.0469 0.2894 0.585
Loa Loa (eye worm) tubulin alpha chain 0.0588 0.3651 0.7394
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Schistosoma mansoni retinoic acid receptor RXR 0.0175 0.1022 0.2065
Giardia lamblia Beta tubulin 0.0791 0.4937 1
Giardia lamblia Alpha-tubulin 0.0588 0.3651 0.7387
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0271
Loa Loa (eye worm) fibroinase 0.0016 0.0017 0.0029
Echinococcus granulosus integrin alpha ps 0.0067 0.034 0.0677
Brugia malayi ecdysteroid receptor 0.0078 0.0407 0.082
Trichomonas vaginalis tubulin gamma chain, putative 0.0791 0.4937 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0152
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Brugia malayi MH2 domain containing protein 0.0234 0.1398 0.2827
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0143 0.0277
Plasmodium vivax vivapain-2 0.0016 0.0017 0.0034
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0017 0.0021
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0017 0.0005
Toxoplasma gondii beta tubulin 0.0791 0.4937 1
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0078 0.0407 0.0401
Brugia malayi nuclear hormone receptor family member nhr-6 0.0037 0.0146 0.029
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0163 0.0947 0.1913
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.015 0.0299
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.016
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0226 0.0445
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0222 0.0444
Schistosoma mansoni tyrosine kinase 0.0047 0.0212 0.0423
Echinococcus multilocularis beta tubulin 0.0791 0.4937 0.4934
Leishmania major alpha tubulin 0.0588 0.3651 0.7392
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0136 0.0262
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0006 0.0006
Brugia malayi PAS domain containing protein 0.0048 0.0216 0.0432
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0065 0.0132
Onchocerca volvulus 0.0047 0.0213 0.1382
Echinococcus granulosus twitchin 0.0023 0.0062 0.0112
Trichomonas vaginalis tubulin alpha chain, putative 0.024 0.1438 0.2903
Leishmania major zeta tubulin, putative 0.0477 0.2941 0.5951
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0193 0.0391
Echinococcus multilocularis protein dispatched 1 0.0094 0.0512 0.0506
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0015 0.0017
Onchocerca volvulus 0.0078 0.0407 0.2745
Schistosoma mansoni tyrosine kinase 0.0161 0.0936 0.189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis tubulin alpha 3 chain 0.0588 0.3651 0.3647
Schistosoma mansoni tubulin subunit beta 0.0203 0.12 0.2426
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0661 0.4845
Brugia malayi nuclear receptor RXR 0.0037 0.0146 0.029
Brugia malayi Tubulin alpha chain 0.0588 0.3651 0.7394
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Schistosoma mansoni tyrosine kinase 0.0047 0.0212 0.0423
Loa Loa (eye worm) hypothetical protein 0.0049 0.0222 0.0444
Loa Loa (eye worm) hypothetical protein 0.0114 0.0634 0.128
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0065 0.0339
Schistosoma mansoni agrin 0.0037 0.015 0.0297
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0193 0.0378
Trichomonas vaginalis tubulin beta chain, putative 0.0588 0.3651 0.7392
Brugia malayi SPARC precursor 0.0037 0.015 0.0299
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0065 0.0125
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0109 0.0216
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0015 0.0017
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.0324 0.0652
Schistosoma mansoni Smad4 0.0016 0.0014 0.0021
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0019 0.003 0.0054
Brugia malayi Kelch motif family protein 0.0047 0.0209 0.0419
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0041 0.0174 0.0345
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 96 % Growth inhibition of Mycobacterium tuberculosis H37Rv at 6.25 ug/mL by microplate alamar blue assay ChEMBL. 17561405
GI (functional) = 96 % Growth inhibition of Mycobacterium tuberculosis H37Rv at 6.25 ug/mL by microplate alamar blue assay ChEMBL. 17561405
GI50 (functional) -5.516 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.864 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.792 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.785 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.757 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.752 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.751 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.672 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.628 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.488 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.168 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (ADMET) = 7.61 ug ml-1 Cytotoxicity against Vero cells ChEMBL. 17561405
MIC (functional) > 6.25 ug ml-1 Antituberculosis activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay ChEMBL. 17561405
MIC (functional) > 6.25 ug ml-1 Antituberculosis activity against Mycobacterium tuberculosis H37Rv by microplate alamar blue assay ChEMBL. 17561405

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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