Detailed information for compound 442528

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 462.928 | Formula: C25H23ClN4O3
  • H donors: 3 H acceptors: 3 LogP: 3.57 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)n1ccccc1=O)NC(CNC(=O)c1ccc2c(c1)[nH]cc2Cl)(C)C
  • InChi: 1S/C25H23ClN4O3/c1-25(2,15-28-23(32)17-8-11-19-20(26)14-27-21(19)13-17)29-24(33)16-6-9-18(10-7-16)30-12-4-3-5-22(30)31/h3-14,27H,15H2,1-2H3,(H,28,32)(H,29,33)
  • InChiKey: XVTPOEYAYGAECC-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens coagulation factor X Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Schistosoma mansoni cpg binding protein 0.0028 0.0092 0.011
Schistosoma mansoni tubulin subunit alpha 0.0583 0.3652 0.4569
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0014
Loa Loa (eye worm) TK protein kinase 0.0104 0.058 0.1171
Trypanosoma cruzi tubulin delta chain 0.0363 0.2242 0.4536
Schistosoma mansoni alpha tubulin 0.0583 0.3652 0.4569
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.0201 0.1201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0146
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0038 0.0153 0.0281
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Giardia lamblia Gamma tubulin 0.0465 0.2895 0.585
Leishmania major beta tubulin 0.0783 0.4939 1
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0107 0.021
Schistosoma mansoni tubulin subunit delta 0.0201 0.1201 0.1499
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0265
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Brugia malayi sulfakinin receptor protein 0.0217 0.1307 0.2642
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0023 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Brugia malayi secreted modular calcium-binding protein 1 0.0037 0.015 0.0299
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0177
Loa Loa (eye worm) acetyltransferase 0.014 0.0811 0.1638
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Trichomonas vaginalis glutathione reductase, putative 0.0016 0.0015 0.0017
Trypanosoma brucei alpha tubulin, putative 0.0238 0.1438 0.2903
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0045 0.0203 0.0405
Brugia malayi hypothetical protein 0.0046 0.0209 0.0419
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Echinococcus multilocularis Niemann Pick C1 protein 0.0191 0.1137 0.1131
Echinococcus granulosus epidermal growth factor receptor 0.016 0.0936 0.1885
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0208
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0044 0.0193 0.0187
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0274 0.0548
Loa Loa (eye worm) hypothetical protein 0.0039 0.0164 0.0328
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Loa Loa (eye worm) tubulin gamma chain 0.0465 0.2895 0.586
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.0193 0.0386
Leishmania major gamma-tubulin 0.0465 0.2895 0.5857
Echinococcus multilocularis epidermal growth factor receptor 0.016 0.0936 0.093
Echinococcus granulosus tubulin epsilon chain 0.0464 0.2893 0.5852
Echinococcus multilocularis Solute carrier organic anion transporter family 0.0054 0.026 0.0254
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0027
Loa Loa (eye worm) alpha-tubulin 0.0583 0.3652 0.7394
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0138 0.08 0.1608
Loa Loa (eye worm) tubulin beta-1 chain 0.0783 0.4939 1
Loa Loa (eye worm) cysteine protease 0.0016 0.0017 0.0029
Onchocerca volvulus 0.0016 0.0017 0.0007
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0137 0.0273
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0201 0.1201 0.2421
Echinococcus granulosus tubulin alpha 3 chain 0.0583 0.3652 0.7392
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0221 0.0443
Echinococcus multilocularis epidermal growth factor receptor 0.0294 0.1798 0.1792
Leishmania major beta tubulin 0.0783 0.4939 1
Trichomonas vaginalis tubulin beta chain, putative 0.0583 0.3652 0.7392
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0143 0.0277
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.016 0.0936 0.1885
Echinococcus multilocularis tubulin alpha 3 chain 0.0583 0.3652 0.3648
Trichomonas vaginalis bromodomain-containing protein, putative 0.0041 0.0177 0.0345
Trypanosoma brucei beta tubulin 0.0783 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0221 0.0272
Echinococcus granulosus L aminoadipate semialdehyde 0.0161 0.0947 0.1906
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0143 0.0277
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0024 0.0065 0.0133
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.006 0.0343
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0249 0.1513 0.3061
Schistosoma mansoni RAR-like nuclear receptor 0.0138 0.08 0.0997
Brugia malayi MH2 domain containing protein 0.0231 0.1398 0.2826
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0028 0.0091 0.0085
Loa Loa (eye worm) Smad1 0.0016 0.0014 0.0022
Onchocerca volvulus 0.0035 0.0137 0.0852
Loa Loa (eye worm) hypothetical protein 0.0046 0.0209 0.0419
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0138 0.08 0.1608
Echinococcus multilocularis protein dispatched 1 0.0093 0.0512 0.0506
Giardia lamblia Beta tubulin 0.0783 0.4939 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0138 0.08 0.1615
Brugia malayi Tubulin beta chain 0.0238 0.1438 0.2909
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0044 0.0193 0.0378
Giardia lamblia GTOR 0.0044 0.0193 0.0362
Onchocerca volvulus 0.0054 0.026 0.1719
Toxoplasma gondii alpha tubulin TUBA1 0.0583 0.3652 0.7393
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0143 0.0261
Trichomonas vaginalis tubulin gamma chain, putative 0.0464 0.2893 0.5852
Echinococcus granulosus tubulin beta 4A class IVa 0.0783 0.4939 1
Onchocerca volvulus 0.0023 0.006 0.0313
Onchocerca volvulus 0.0016 0.0017 0.0007
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0331 0.0665
Onchocerca volvulus 0.0065 0.0331 0.2215
Loa Loa (eye worm) hypothetical protein 0.0345 0.2126 0.4302
Loa Loa (eye worm) hypothetical protein 0.0026 0.0082 0.016
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0137 0.0918
Echinococcus granulosus tubulin alpha chain 0.0583 0.3652 0.7392
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0381 0.0767
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0101 0.0562 0.0556
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.003 0.0033
Brugia malayi hypothetical protein 0.0065 0.0331 0.0665
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Brugia malayi prostaglandin transporter 0.0054 0.026 0.0522
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0125
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0023 0.0017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0138 0.08 0.0997
Echinococcus multilocularis integrin beta 2 0.0226 0.136 0.1355
Echinococcus multilocularis GPCR, family 2 0.0015 0.001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Echinococcus multilocularis geminin 0.0329 0.202 0.2015
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0015 0.0025
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0214
Brugia malayi hypoxia-induced factor 1 0.0146 0.0852 0.1721
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.003 0.0024
Mycobacterium ulcerans lipase LipD 0.0035 0.0137 0.1032
Toxoplasma gondii cathepsin CPL 0.0016 0.0017 0.0027
Loa Loa (eye worm) TK protein kinase 0.0034 0.0129 0.0255
Echinococcus multilocularis tubulin subunit TubB 0.0583 0.3652 0.3648
Echinococcus granulosus tyrosine protein kinase Src64B 0.0047 0.0212 0.0417
Brugia malayi hypothetical protein 0.007 0.036 0.0724
Plasmodium vivax tubulin gamma chain, putative 0.0465 0.2895 0.5862
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0113 0.0634 0.128
Onchocerca volvulus 0.0016 0.0017 0.0007
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0047 0.0212 0.0206
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1513 0.3055
Onchocerca volvulus 0.0065 0.0331 0.2215
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0065 0.0331 0.0665
Plasmodium falciparum tubulin beta chain 0.0783 0.4939 1
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.1201 0.2421
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Toxoplasma gondii transporter, major facilitator family protein 0.0054 0.026 0.0521
Trypanosoma cruzi target of rapamycin kinase 3 0.0035 0.0136 0.0268
Schistosoma mansoni egf-like domain protein 0.0016 0.0016 0.0016
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.003 0.0024
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0073 0.0381 0.0375
Loa Loa (eye worm) hypoxia-induced factor 1 0.0146 0.0852 0.1721
Echinococcus multilocularis roundabout 2 0.0029 0.0098 0.0092
Echinococcus granulosus tyrosine protein kinase Src42A 0.0035 0.0137 0.0264
Loa Loa (eye worm) SRC-1 0.0047 0.0212 0.0425
Entamoeba histolytica tubulin alpha chain, putative 0.0583 0.3652 0.7395
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0065 0.0119
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0271
Leishmania major beta tubulin 0.0783 0.4939 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0208 0.0413
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0311 0.0622
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Echinococcus granulosus sterol regulatory element binding protein 0.0082 0.0438 0.0875
Schistosoma mansoni tyrosine kinase 0.0294 0.1798 0.2247
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0044 0.0193 0.0378
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0015 0.0023
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Brugia malayi Tubulin gamma chain 0.0465 0.2895 0.586
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0161 0.0947 0.1181
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0014 0.0022
Echinococcus granulosus bloom syndrome protein 0.004 0.0169 0.033
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0124 0.0245
Leishmania major epsilon tubulin, putative 0.0464 0.2893 0.5852
Loa Loa (eye worm) alpha-tubulin 0.0583 0.3652 0.7394
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.08 0.1608
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0138 0.08 0.1615
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0044 0.0193 0.0237
Brugia malayi Kelch motif family protein 0.0046 0.0209 0.0419
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Echinococcus multilocularis tubulin subunit beta 0.0783 0.4939 0.4935
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0059 0.0293 0.0362
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0331 0.0325
Brugia malayi steroid hormone receptor 0.0138 0.08 0.1615
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.006 0.0122
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0196 0.019
Onchocerca volvulus Putative organic anion transporter 0.0054 0.026 0.1719
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0137 0.0265
Loa Loa (eye worm) isocitrate dehydrogenase 0.0031 0.0109 0.0216
Leishmania major beta tubulin 0.0783 0.4939 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0017
Brugia malayi hypothetical protein 0.0217 0.1307 0.2642
Loa Loa (eye worm) tubulin alpha-3 chain 0.0345 0.2126 0.4302
Loa Loa (eye worm) hypothetical protein 0.0028 0.0091 0.0179
Loa Loa (eye worm) hypothetical protein 0.0161 0.0947 0.1913
Leishmania major beta tubulin 0.0783 0.4939 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0138 0.08 0.1615
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0661 0.5265
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0208
Loa Loa (eye worm) tubulin alpha 2 0.0144 0.0838 0.1693
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0586 0.4282
Leishmania major cysteine peptidase A (CPA) 0.0016 0.0017 0.0021
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0226 0.0451
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0015 0.0017
Brugia malayi hypothetical protein 0.0159 0.0931 0.1881
Onchocerca volvulus 0.0054 0.026 0.1719
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni tubulin subunit beta 0.0783 0.4939 0.618
Echinococcus multilocularis follistatin 0.0037 0.015 0.0144
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.026 0.0522
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Schistosoma mansoni defective proboscis extension response (dpr)-related 0.002 0.0043 0.005
Brugia malayi Fibulin-1 precursor 0.0016 0.0016 0.0027
Plasmodium falciparum thioredoxin reductase 0.0046 0.0208 0.0392
Echinococcus granulosus tyrosine protein kinase Blk 0.004 0.0171 0.0334
Trichomonas vaginalis tubulin alpha chain, putative 0.0238 0.1438 0.2903
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Onchocerca volvulus Protein ultraspiracle homolog 0.0138 0.08 0.551
Loa Loa (eye worm) kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0299
Schistosoma mansoni hypothetical protein 0.0398 0.2465 0.3083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0196 0.0384
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0324 0.0645
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0082
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0283
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0016 0.0016 0.0016
Echinococcus granulosus tubulin subunit TubB 0.0583 0.3652 0.7392
Schistosoma mansoni cell adhesion molecule 0.0026 0.008 0.0096
Echinococcus multilocularis transfer RNA-Lys 0.0035 0.0137 0.0131
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0221 0.0443
Mycobacterium leprae conserved hypothetical protein 0.0045 0.0203 0.1254
Brugia malayi hypothetical protein 0.0073 0.0381 0.0767
Onchocerca volvulus 0.0238 0.1438 1
Schistosoma mansoni follistatin 0.0037 0.015 0.0184
Schistosoma mansoni tyrosine kinase 0.0206 0.1234 0.1541
Onchocerca volvulus Eukaryotic initiation factor 4A homolog 0.0024 0.0065 0.0345
Echinococcus granulosus Tubulin beta 2C chain 0.0783 0.4939 1
Plasmodium vivax RNA helicase-1, putative 0.0024 0.0065 0.0132
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.08 0.0794
Trichomonas vaginalis tubulin gamma chain, putative 0.0201 0.1201 0.2421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0226 0.0429
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0082
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Brugia malayi CHE-14 protein 0.0082 0.0438 0.0882
Onchocerca volvulus 0.0016 0.0017 0.0007
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0015 0.0017
Echinococcus granulosus expressed conserved protein 0.0179 0.1063 0.2142
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.0276 0.0552
Brugia malayi Steroid receptor seven-up type 2 0.0138 0.08 0.1615
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.026 0.0522
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0013
Brugia malayi photoreceptor-specific nuclear receptor 0.0138 0.08 0.1615
Plasmodium vivax delta tubulin, putative 0.0201 0.1201 0.2431
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0081 0.0158
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0311 0.0622
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0152 0.0295
Loa Loa (eye worm) phosphatidylinositol 3 0.0015 0.0006 0.0008
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0249 0.1513 0.3061
Schistosoma mansoni tyrosine kinase 0.016 0.0936 0.1168
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0311 0.0622
Echinococcus multilocularis survival motor neuron protein 1 0.023 0.1388 0.1383
Echinococcus granulosus c src tyrosine kinase 0.0018 0.003 0.0048
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0331 0.2215
Echinococcus granulosus smad 0.0016 0.0014 0.0014
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0045 0.0203 0.1591
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0208 0.0201
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.006 0.0385
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0041 0.0177 0.0345
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0045 0.0203 0.1415
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0047 0.0212 0.0417
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni organic anion transporter 0.0054 0.026 0.0322
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0027
Echinococcus multilocularis tubulin epsilon chain 0.0464 0.2893 0.2888
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0143 0.0175
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0017 0.0007
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0028 0.0091 0.0085
Echinococcus granulosus tm gpcr rhodopsin 0.0514 0.3212 0.6498
Schistosoma mansoni hypothetical protein 0.0101 0.0558 0.0694
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0023 0.0046
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0045 0.0078
Plasmodium falciparum eukaryotic initiation factor 4A 0.0024 0.0065 0.0102
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0137 0.0918
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Echinococcus granulosus Tolloid protein 1 0.0016 0.0016 0.0019
Brugia malayi tubulin alpha-2 chain 0.0583 0.3652 0.7394
Brugia malayi Tubulin beta-1 chain 0.0783 0.4939 1
Echinococcus granulosus beta tubulin 0.0783 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Brugia malayi nuclear receptor NHR-88 0.0138 0.08 0.1615
Echinococcus granulosus agrin 0.0037 0.015 0.0291
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0015 0.003
Onchocerca volvulus Putative organic anion transporter 0.0054 0.026 0.1719
Loa Loa (eye worm) DR-78 0.0065 0.0331 0.0665
Brugia malayi Tubulin alpha chain 0.0201 0.1201 0.2427
Trichomonas vaginalis tubulin epsilon chain, putative 0.0201 0.1201 0.2421
Echinococcus granulosus insulin receptor 0.0096 0.0531 0.1063
Loa Loa (eye worm) hypothetical protein 0.0032 0.0117 0.0233
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0045 0.0203 0.1591
Schistosoma mansoni alpha tubulin 0.0583 0.3652 0.4569
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0138 0.08 0.1615
Echinococcus multilocularis tyrosine protein kinase Fyn 0.004 0.0171 0.0165
Loa Loa (eye worm) hypothetical protein 0.0217 0.1307 0.2642
Brugia malayi nuclear receptor NHR-67 0.0065 0.0331 0.0665
Onchocerca volvulus 0.0016 0.0017 0.0007
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Onchocerca volvulus 0.0047 0.0213 0.1389
Echinococcus granulosus neuroglian 0.0023 0.0062 0.0112
Loa Loa (eye worm) integrin beta-2 0.0305 0.1867 0.3777
Schistosoma mansoni cathepsin F (C01 family) 0.0016 0.0017 0.0017
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0783 0.4939 0.4935
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0014 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0167
Echinococcus multilocularis tyrosine protein kinase Abl 0.0095 0.0522 0.0516
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0045 0.0203 0.0412
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0018 0.0029 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0138 0.08 0.1615
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0196 0.0241
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0137 0.0273
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0143 0.0277
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Entamoeba histolytica tubulin family protein 0.0783 0.4939 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.001 0.0004
Trypanosoma cruzi tubulin delta chain 0.0363 0.2242 0.4536
Leishmania major beta tubulin 0.0783 0.4939 1
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.007 0.036 0.0354
Plasmodium vivax tubulin alpha chain, putative 0.0583 0.3652 0.7395
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Loa Loa (eye worm) integrin alpha pat-2 0.0229 0.1384 0.2798
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0586 0.4282
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Brugia malayi hypothetical protein 0.0065 0.0331 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Schistosoma mansoni vesicular amine transporter 0.002 0.0043 0.005
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0015
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0155 0.0284
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus granulosus FTZ F1 alpha 0.0138 0.08 0.1608
Giardia lamblia Alpha-tubulin 0.0583 0.3652 0.7387
Mycobacterium ulcerans beta-lactamase 0.0035 0.0137 0.1032
Echinococcus multilocularis expressed conserved protein 0.0179 0.1063 0.1057
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0015 0.0023
Brugia malayi Tubulin alpha-2 chain 0.0583 0.3652 0.7394
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis integrin alpha ps 0.0067 0.034 0.0334
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0138 0.08 0.0997
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1513 0.3055
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Loa Loa (eye worm) sodium-independent organic anion transporter 0.0054 0.026 0.0522
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0041 0.0177 0.0358
Schistosoma mansoni nuclear receptor 0.0065 0.0331 0.041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0196 0.019
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0065 0.0331 0.0658
Loa Loa (eye worm) tubulin beta-2A chain 0.0783 0.4939 1
Echinococcus multilocularis tubulin alpha chain 0.0583 0.3652 0.3648
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0363 0.2242 0.4536
Brugia malayi tubulin alpha chain - mouse 0.0583 0.3652 0.7394
Schistosoma mansoni lamin 0.0026 0.0081 0.0097
Schistosoma mansoni aryl hydrocarbon receptor 0.0047 0.0216 0.0266
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0031 0.0109 0.0221
Loa Loa (eye worm) hypothetical protein 0.0082 0.0438 0.0882
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Onchocerca volvulus 0.0161 0.0947 0.6543
Trichomonas vaginalis tubulin, putative 0.0783 0.4939 1
Plasmodium vivax vivapain-2 0.0016 0.0017 0.0034
Leishmania major beta tubulin 0.0783 0.4939 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0177
Loa Loa (eye worm) TK/EGFR protein kinase 0.0294 0.1798 0.3637
Toxoplasma gondii protease inhibitor PI2 0.0037 0.015 0.0297
Loa Loa (eye worm) tubulin alpha-2 chain 0.0583 0.3652 0.7394
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0196 0.0392
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0044 0.0193 0.0391
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Echinococcus multilocularis Tubulin beta 2C chain 0.0783 0.4939 0.4935
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.001 0.0015
Leishmania major phosphopantetheinyl transferase-like protein 0.0045 0.0203 0.0399
Echinococcus multilocularis laminin 0.0016 0.0016 0.0009
Echinococcus multilocularis tubulin beta 1 chain 0.0783 0.4939 0.4935
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0028 0.0091 0.0172
Toxoplasma gondii eukaryotic initiation factor-4A, putative 0.0024 0.0065 0.0125
Toxoplasma gondii thioredoxin reductase 0.0046 0.0208 0.0413
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0016 0.0017 0.0029
Brugia malayi Bloom's syndrome protein homolog 0.004 0.0169 0.0338
Mycobacterium tuberculosis Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) 0.0024 0.0065 0.0378
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0065 0.0331 0.0665
Echinococcus granulosus tubulin subunit beta 0.0783 0.4939 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0661 0.4845
Giardia lamblia Delta tubulin 0.0201 0.1201 0.2408
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Echinococcus granulosus tubulin alpha 1C chain 0.0583 0.3652 0.7392
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0138 0.08 0.1615
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1513 0.3055
Trypanosoma brucei alpha tubulin 0.0583 0.3652 0.7392
Echinococcus multilocularis sterol regulatory element binding protein 0.0082 0.0438 0.0432
Echinococcus multilocularis beta tubulin 0.0783 0.4939 0.4935
Brugia malayi conserved hypotetical protein 0.0065 0.0331 0.0665
Trichomonas vaginalis tubulin gamma chain, putative 0.0783 0.4939 1
Leishmania major cathepsin L-like protease 0.0062 0.0311 0.0617
Plasmodium vivax glutathione reductase, putative 0.0046 0.0208 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0143 0.0137
Brugia malayi ecdysone receptor 0.0065 0.0331 0.0665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0331 0.0658
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0016 0.0025
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Echinococcus granulosus Tubulin beta 2C chain 0.0783 0.4939 1
Echinococcus granulosus tubulin alpha chain 0.0583 0.3652 0.7392
Loa Loa (eye worm) hypothetical protein 0.0082 0.0439 0.0884
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.027 0.0264
Brugia malayi Latrophilin receptor protein 2 0.0015 0.001 0.0015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0078 0.0152
Trypanosoma brucei tubulin gamma chain 0.0465 0.2895 0.5857
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0045 0.0203 0.1591
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0138 0.08 0.1615
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0143 0.0137
Toxoplasma gondii calcium binding egf domain-containing protein 0.0016 0.0016 0.0025
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0137 0.0265
Loa Loa (eye worm) TK/INSR protein kinase 0.0096 0.0531 0.1071
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0214
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0143 0.0277
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0017
Mycobacterium tuberculosis Cell division protein FtsZ 0.0201 0.1201 0.8894
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0151 0.0293
Trypanosoma cruzi zeta tubulin, putative 0.0472 0.2942 0.5953
Brugia malayi protein-tyrosine kinase 0.004 0.0171 0.0341
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0013
Trichomonas vaginalis tubulin beta chain, putative 0.0583 0.3652 0.7392
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Brugia malayi Cell division protein ftsZ 0.0201 0.1201 0.2427
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Schistosoma mansoni hypothetical protein 0.0079 0.0419 0.052
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.001 0.0008
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0226 0.0429
Echinococcus multilocularis organic anion transporting polypeptide 30B 0.0054 0.026 0.0254
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0017 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.027 0.2157
Treponema pallidum NADH oxidase 0.0016 0.0015 0.0094
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Echinococcus multilocularis integrin alpha ps 0.0032 0.0117 0.0111
Trypanosoma cruzi cysteine peptidase, putative 0.0016 0.0017 0.0027
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0586 0.4282
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0107 0.0204
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Schistosoma mansoni hypothetical protein 0.0079 0.0419 0.052
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Brugia malayi Calcium binding EGF domain containing protein 0.0016 0.0016 0.0027
Echinococcus multilocularis Tubulin alpha 1 chain 0.0583 0.3652 0.3648
Echinococcus multilocularis neuropeptide s receptor 0.0458 0.2853 0.2848
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.004 0.0171 0.0334
Echinococcus multilocularis integrin alpha 3 0.0114 0.0644 0.0638
Mycobacterium tuberculosis Probable reductase 0.0105 0.0586 0.4282
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.007 0.036 0.0717
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0324 0.065
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0918
Echinococcus granulosus Tubulin alpha 1 chain 0.0583 0.3652 0.7392
Trichomonas vaginalis DNA helicase recq1, putative 0.004 0.0169 0.033
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0094 0.0178
Echinococcus multilocularis fibrillin 1 0.0026 0.0079 0.0072
Trichomonas vaginalis mercuric reductase, putative 0.0016 0.0015 0.0017
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0138 0.08 0.1615
Mycobacterium leprae cell division protein FtsZ 0.0201 0.1201 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0015 0.0023
Trypanosoma brucei epsilon tubulin 0.0464 0.2893 0.5852
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.0767
Loa Loa (eye worm) RecQ helicase 0.004 0.0169 0.0338
Schistosoma mansoni hypothetical protein 0.0047 0.0213 0.0263
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0029 0.0096 0.019
Echinococcus multilocularis hypothetical protein 0.0583 0.3652 0.3648
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0015 0.0017
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.006 0.0385
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Loa Loa (eye worm) hypothetical protein 0.0023 0.0062 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0311 0.0622
Giardia lamblia Beta tubulin 0.0783 0.4939 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Trypanosoma cruzi beta tubulin, putative 0.0783 0.4939 1
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0022
Echinococcus multilocularis tubulin alpha 3 chain 0.0583 0.3652 0.3648
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0138 0.08 0.1615
Echinococcus granulosus survival motor neuron protein 1 0.023 0.1388 0.2801
Echinococcus granulosus fibroblast growth factor receptor 4 0.0101 0.0562 0.1126
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0138 0.08 0.1615
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0155 0.0284
Loa Loa (eye worm) fibroinase 0.0016 0.0017 0.0029
Echinococcus multilocularis neuroglian 0.0023 0.0062 0.0055
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0226 0.0451
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0213 0.0427
Trypanosoma brucei beta tubulin 0.0783 0.4939 1
Loa Loa (eye worm) TK protein kinase 0.004 0.0171 0.0341
Brugia malayi Nuclear hormone receptor-like 1 0.0138 0.08 0.1615
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0029
Echinococcus multilocularis Tolloid protein 1 0.0016 0.0016 0.0009
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.001
Echinococcus granulosus tyrosine kinase 0.004 0.0171 0.0334
Onchocerca volvulus Glucosylceramidase homolog 0.0164 0.0963 0.6657
Echinococcus granulosus nuclear receptor nhr 48 0.0065 0.0331 0.0658
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0138 0.08 0.1608
Loa Loa (eye worm) hypothetical protein 0.0035 0.0135 0.0269
Onchocerca volvulus 0.0054 0.026 0.1719
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.006 0.0385
Brugia malayi hypothetical protein 0.0032 0.0115 0.0227
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0031 0.0109 0.0707
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0015 0.0008
Schistosoma mansoni tyrosine kinase 0.0047 0.0212 0.0261
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0047 0.0212 0.0206
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0191 0.1137 0.2303
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0143 0.0277
Plasmodium falciparum tubulin delta chain, putative 0.0201 0.1201 0.2408
Schistosoma mansoni hypothetical protein 0.0079 0.0419 0.052
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0137 0.0265
Echinococcus granulosus Niemann Pick C1 protein 0.0191 0.1137 0.2292
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0331 0.0325
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0137 0.0271
Trypanosoma cruzi Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2465 0.4985
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0137 0.0131
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.001
Giardia lamblia Alpha-tubulin 0.0583 0.3652 0.7387
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0138 0.08 0.1615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0045 0.0203 0.0405
Brugia malayi Isocitrate dehydrogenase 0.0031 0.0109 0.0216
Echinococcus granulosus peroxisome assembly protein 26 0.0583 0.3652 0.7392
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2465 0.246
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0179
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0129 0.0122
Schistosoma mansoni single-minded 0.0047 0.0216 0.0266
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0031 0.0109 0.0191
Schistosoma mansoni tubulin subunit beta 0.0783 0.4939 0.618
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0046 0.0209 0.0419
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0022
Leishmania major eukaryotic initiation factor 4a, putative 0.0024 0.0065 0.0119
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0586 0.4282
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0006 0.0006
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Loa Loa (eye worm) tubulin beta chain 0.0201 0.1201 0.2427
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0031 0.0109 0.0132
Mycobacterium ulcerans hypothetical protein 0.0035 0.0137 0.1032
Trichomonas vaginalis tubulin beta chain, putative 0.0783 0.4939 1
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus granulosus tumor protein p63 0.0329 0.2021 0.4085
Echinococcus granulosus Tubulin alpha 1 chain 0.0583 0.3652 0.7392
Echinococcus granulosus neuropeptide receptor A26 0.0458 0.2853 0.5771
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0208 0.0415
Entamoeba histolytica DEAD/DEAH box helicase, putative 0.0024 0.0065 0.0132
Echinococcus multilocularis smad 0.0016 0.0014 0.0007
Schistosoma mansoni steroid hormone receptor ad4bp 0.0138 0.08 0.0997
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0023 0.0062 0.0119
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0138 0.08 0.1608
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0138 0.08 0.1615
Brugia malayi nuclear hormone receptor family member odr-7 0.0065 0.0331 0.0665
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0045 0.0203 0.1669
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0208 0.0408
Brugia malayi Smad1 0.0016 0.0014 0.0022
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Trypanosoma brucei beta tubulin 0.0783 0.4939 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Loa Loa (eye worm) hypothetical protein 0.0117 0.0662 0.1335
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis insulin receptor 0.0096 0.0531 0.0525
Echinococcus granulosus beta tubulin 0.0783 0.4939 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0047 0.0212 0.0417
Echinococcus granulosus tyrosine protein kinase ABL1 0.0213 0.1276 0.2574
Echinococcus granulosus tubulin alpha 3 chain 0.0583 0.3652 0.7392
Trypanosoma cruzi epsilon tubulin, putative 0.0464 0.2893 0.5854
Echinococcus granulosus cathepsin L cysteine proteinase 0.0016 0.0017 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0137 0.0918
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0382 0.2364 0.4784
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0208 0.1446
Echinococcus multilocularis Smad4 0.0016 0.0014 0.0007
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0031 0.0109 0.0208
Echinococcus multilocularis agrin 0.0037 0.015 0.0144
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0031 0.0109 0.0103
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0246 0.0494
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Brugia malayi SPARC precursor 0.0037 0.015 0.0299
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.001 0.0004
Echinococcus granulosus Smad4 0.0016 0.0014 0.0014
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0016 0.0017 0.0005
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0586 0.4606
Plasmodium falciparum tubulin gamma chain 0.0465 0.2895 0.585
Trypanosoma cruzi epsilon tubulin, putative 0.0464 0.2893 0.5854
Loa Loa (eye worm) BEN-1 protein 0.0783 0.4939 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0161 0.0947 0.1913
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.0443
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0047 0.0212 0.0206
Loa Loa (eye worm) beta-lactamase 0.0035 0.0137 0.0273
Schistosoma mansoni thyroid hormone receptor 0.0261 0.1585 0.1981
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Entamoeba histolytica tubulin gamma chain 0.0465 0.2895 0.5862
Schistosoma mansoni coup transcription factor 0.0138 0.08 0.0997
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.006 0.0385
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0138 0.08 0.0997
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0331 0.041
Trichomonas vaginalis conserved hypothetical protein 0.0201 0.1201 0.2421
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Loa Loa (eye worm) MH2 domain-containing protein 0.0231 0.1398 0.2826
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0123
Echinococcus granulosus Protein patched homolog 1 0.0082 0.0438 0.0875
Schistosoma mansoni cpg binding protein 0.003 0.0102 0.0123
Trypanosoma brucei zeta tubulin, putative 0.0472 0.2942 0.5951
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0016 0.0017 0.0005
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0331 0.041
Echinococcus granulosus histone acetyltransferase KAT2B 0.0041 0.0177 0.0345
Schistosoma mansoni tubulin subunit beta 0.0783 0.4939 0.618
Onchocerca volvulus Cathepsin L homolog 0.0016 0.0017 0.0007
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0035 0.0136 0.0262
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0073 0.0381 0.0473
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Echinococcus multilocularis thyroid hormone receptor alpha 0.0261 0.1585 0.158
Echinococcus granulosus tubulin delta chain 0.0201 0.1201 0.2421
Entamoeba histolytica recQ family DNA helicase 0.0014 0.0003 0.0007
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0015 0.003
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0028 0.0091 0.0179
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.0767
Echinococcus granulosus alpha tubulin 0.0583 0.3652 0.7392
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0065 0.0331 0.0325
Echinococcus multilocularis peroxisome assembly protein 26 0.0583 0.3652 0.3648
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0016 0.0016 0.0027
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0015 0.0006 0.0008
Echinococcus granulosus organic anion transporting polypeptide 30B 0.0054 0.026 0.0515
Echinococcus multilocularis tubulin alpha 1C chain 0.0583 0.3652 0.3648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0149
Brugia malayi PAS domain containing protein 0.0047 0.0216 0.0432
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis FTZ F1 alpha 0.0138 0.08 0.0794
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi Furin-like cysteine rich region family protein 0.0294 0.1798 0.3637
Brugia malayi acetyltransferase, GNAT family protein 0.014 0.0811 0.1638
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1513 0.3055
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0918
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0047 0.0212 0.0417
Schistosoma mansoni hypothetical protein 0.0033 0.0124 0.0151
Loa Loa (eye worm) hypothetical protein 0.0159 0.0931 0.1881
Onchocerca volvulus 0.0054 0.026 0.1719
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0324 0.0652
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0101 0.0562 0.1126
Brugia malayi hypothetical protein 0.0049 0.0226 0.0453
Toxoplasma gondii beta tubulin 0.0783 0.4939 1
Onchocerca volvulus Bile acid receptor homolog 0.0138 0.08 0.551
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0324 0.0645
Treponema pallidum cell division protein FtsZ 0.0201 0.1201 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0138 0.08 0.1615
Plasmodium falciparum alpha tubulin 1 0.0583 0.3652 0.7387
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Echinococcus multilocularis integrin alpha ps 0.0067 0.034 0.0334
Loa Loa (eye worm) BEN-1 protein 0.0783 0.4939 1
Echinococcus granulosus cathepsin l1 0.0016 0.0017 0.0021
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0044 0.0193 0.0384
Schistosoma mansoni Smad4 0.0016 0.0014 0.0013
Plasmodium falciparum cysteine proteinase falcipain 3 0.0016 0.0017 0.0005
Brugia malayi Tubulin alpha-2 chain 0.0583 0.3652 0.7394
Echinococcus granulosus tubulin beta 1 chain 0.0783 0.4939 1
Leishmania major trypanothione reductase 0.0046 0.0208 0.0408
Echinococcus multilocularis Tubulin beta 2C chain 0.0783 0.4939 0.4935
Loa Loa (eye worm) beta-tubulin 0.0783 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0023 0.0041
Entamoeba histolytica hypothetical protein 0.0045 0.0203 0.0412
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0023 0.0062 0.0113
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.001 0.0008
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Loa Loa (eye worm) hypothetical protein 0.023 0.1388 0.2807
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0138 0.08 0.1615
Mycobacterium ulcerans cell division protein FtsZ 0.0201 0.1201 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0783 0.4939 0.4935
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Echinococcus multilocularis nuclear receptor nhr 48 0.0065 0.0331 0.0325
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0138 0.08 0.1615
Echinococcus granulosus integrin beta 2 0.0226 0.136 0.2745
Loa Loa (eye worm) TK/ABL protein kinase 0.0213 0.1276 0.258
Echinococcus granulosus intermediate filament protein 0.0026 0.0081 0.0151
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0027
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0143 0.0175
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Toxoplasma gondii isocitrate dehydrogenase 0.0031 0.0109 0.0214
Schistosoma mansoni alpha tubulin 0.0583 0.3652 0.4569
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0137 0.0278
Trypanosoma brucei Eukaryotic initiation factor 4A-1 0.0024 0.0065 0.0119
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0073 0.0381 0.0473
Leishmania major beta tubulin 0.0783 0.4939 1
Schistosoma mansoni tubulin subunit beta 0.0783 0.4939 0.618
Schistosoma mansoni hypothetical protein 0.0329 0.202 0.2526
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0698 0.1402
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0045 0.0203 0.0383
Echinococcus granulosus tubulin alpha chain 0.0583 0.3652 0.7392
Trichomonas vaginalis tubulin epsilon chain, putative 0.0583 0.3652 0.7392
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0158
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0227 0.1367 0.2762
Trypanosoma brucei hypothetical protein, conserved 0.0045 0.0203 0.0399
Toxoplasma gondii tubulin, putative 0.0026 0.0079 0.0152
Brugia malayi Integrin beta pat-3 precursor 0.0305 0.1867 0.3777
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0514 0.3212 0.3207
Loa Loa (eye worm) tubulin alpha chain 0.0583 0.3652 0.7394
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0044 0.0193 0.0391
Loa Loa (eye worm) transcription factor SMAD2 0.0231 0.1398 0.2826
Trichomonas vaginalis tubulin, putative 0.0238 0.1438 0.2903
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0208 0.042
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0137 0.0918
Onchocerca volvulus 0.0048 0.0221 0.1442
Schistosoma mansoni tyrosine kinase 0.0154 0.0902 0.1125
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0056 0.027 0.0535
Entamoeba histolytica recQ family helicase, putative 0.003 0.0107 0.0217
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0031 0.0109 0.0208
Schistosoma mansoni smad 0.0016 0.0014 0.0013
Echinococcus granulosus geminin 0.0329 0.202 0.4083
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.1259 0.7989 1
Brugia malayi CXXC zinc finger family protein 0.0028 0.0092 0.018
Echinococcus multilocularis tumor protein p63 0.0329 0.2021 0.2016
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0143 0.0277
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0028 0.0091 0.0179
Toxoplasma gondii beta-1 tubulin, putative 0.0783 0.4939 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Brugia malayi nuclear hormone receptor family member nhr-6 0.0065 0.0331 0.0665
Brugia malayi hypothetical protein 0.0054 0.026 0.0522
Loa Loa (eye worm) glutathione reductase 0.0046 0.0208 0.0415
Entamoeba histolytica cysteine protease, putative 0.0016 0.0017 0.0034
Brugia malayi SRC-1 0.0047 0.0212 0.0425
Loa Loa (eye worm) tubulin alpha chain 0.0583 0.3652 0.7394
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0015 0.0023
Onchocerca volvulus 0.0016 0.0017 0.0007
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0137 0.0167
Schistosoma mansoni hypothetical protein 0.0079 0.0419 0.052
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0044 0.0193 0.0384
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0014 0.0022
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0583 0.3652 0.7392
Trichomonas vaginalis conserved hypothetical protein 0.0082 0.0438 0.0875
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.003 0.0048
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0041 0.0177 0.0351
Trichomonas vaginalis tubulin beta chain, putative 0.0583 0.3652 0.7392
Trypanosoma brucei zeta tubulin 0.0472 0.2942 0.5951
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0137 0.1032
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Onchocerca volvulus 0.0026 0.0081 0.0456
Echinococcus multilocularis tubulin alpha chain 0.0583 0.3652 0.3648
Schistosoma mansoni lamin 0.0026 0.0081 0.0097
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0586 0.4282
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0439 0.2727 0.5518
Giardia lamblia Epsilon tubulin 0.0227 0.1367 0.2746
Schistosoma mansoni transcription factor LCR-F1 0.007 0.036 0.0446
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0138 0.08 0.0997
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0138 0.08 0.0794
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0016 0.0027
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0035 0.0136 0.0262
Loa Loa (eye worm) hypothetical protein 0.0014 0.0003 0.0002
Echinococcus granulosus histone acetyltransferase KAT2B 0.0136 0.0786 0.158
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0028 0.0091 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0138 0.08 0.1615
Schistosoma mansoni integrin alpha 0.0149 0.0867 0.1081
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Echinococcus granulosus Tubulin beta 2C chain 0.0783 0.4939 1
Leishmania major cathepsin L-like protease 0.0062 0.0311 0.0617
Echinococcus granulosus tubulin alpha chain 0.0583 0.3652 0.7392
Loa Loa (eye worm) hypothetical protein 0.01 0.0556 0.1122
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Trichomonas vaginalis tubulin, putative 0.0238 0.1438 0.2903
Entamoeba histolytica tubulin alpha-1 chain 0.0583 0.3652 0.7395
Schistosoma mansoni smad1 5 8 and 0.0016 0.0014 0.0013
Brugia malayi ecdysteroid receptor 0.0138 0.08 0.1615
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0277
Leishmania major hypothetical protein, conserved 0.0035 0.0137 0.0265
Echinococcus granulosus Solute carrier organic anion transporter family 0.0054 0.026 0.0515
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0014 0.0007
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0129 0.0248
Schistosoma mansoni hypothetical protein 0.0032 0.0117 0.0143
Echinococcus multilocularis tubulin alpha chain 0.0583 0.3652 0.3648
Echinococcus granulosus laminin 0.0016 0.0016 0.0019
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0143 0.029
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0101 0.0562 0.0556
Echinococcus granulosus twitchin 0.0023 0.0062 0.0112
Brugia malayi nuclear receptor RXR 0.0065 0.0331 0.0665
Brugia malayi tailless protein 0.0065 0.0331 0.0665
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0045 0.0203 1
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.003 0.0107 0.0204
Trichomonas vaginalis tubulin, putative 0.0227 0.1369 0.2763
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1019 0.2054
Brugia malayi hypothetical protein 0.023 0.1388 0.2807
Echinococcus multilocularis 0.009 0.0489 0.0482
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0138 0.08 0.0997
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0017
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0158
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0047 0.0212 0.0206
Onchocerca volvulus 0.0037 0.015 0.0943
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0196 0.0392
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0027
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0137 0.1032
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0078 0.0146
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0121 0.0238
Echinococcus granulosus roundabout 2 0.0029 0.0098 0.0187
Schistosoma mansoni tyrosine kinase 0.0047 0.0212 0.0261
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0324 0.0318
Brugia malayi alpha-tubulin 0.0583 0.3652 0.7394
Schistosoma mansoni nuclear hormone receptor 0.0138 0.08 0.0997
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0155 0.0313
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0014 0.0013
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.014 0.0811 0.0805
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Onchocerca volvulus 0.0035 0.0137 0.0852
Loa Loa (eye worm) hypothetical protein 0.0113 0.0634 0.128
Brugia malayi Nuclear hormone receptor-like 1 0.0073 0.0381 0.0767
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0099 0.0549 0.11
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0073 0.0381 0.076
Mycobacterium tuberculosis Conserved protein 0.0035 0.0137 0.0918
Brugia malayi Thioredoxin reductase 0.0046 0.0208 0.0415
Trichomonas vaginalis glucosylceramidase, putative 0.0173 0.1019 0.2054
Leishmania major cathepsin L-like protease 0.0062 0.0311 0.0617
Schistosoma mansoni tyrosine kinase 0.0154 0.0902 0.1125
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0056 0.027 0.1918
Loa Loa (eye worm) nuclear hormone receptor 0.0065 0.0331 0.0665
Brugia malayi nuclear receptor RXR 0.0073 0.0381 0.0767
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Brugia malayi Immunoglobulin I-set domain containing protein 0.0029 0.0096 0.019
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0265
Brugia malayi nuclear hormone receptor 0.0138 0.08 0.1615
Trypanosoma brucei trypanothione reductase 0.0046 0.0208 0.0408
Entamoeba histolytica protein kinase, putative 0.0034 0.0129 0.0261
Schistosoma mansoni tubulin subunit gamma 0.0465 0.2895 0.3621
Echinococcus multilocularis Niemann Pick C1 protein 0.0273 0.1663 0.1657
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0065 0.0331 0.0325
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0065 0.0077
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.027 0.0543
Echinococcus multilocularis neuropeptide receptor A26 0.0458 0.2853 0.2848
Loa Loa (eye worm) hypothetical protein 0.0049 0.0226 0.0453
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0324 0.065
Brugia malayi hypothetical protein 0.0054 0.026 0.0522
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0661 0.4845
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Echinococcus granulosus single minded 2 0.0035 0.0137 0.0265
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0143 0.0277
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Brugia malayi bHLH-PAS transcription factor 0.0035 0.0137 0.0273
Schistosoma mansoni integrin alpha-ps 0.0035 0.0135 0.0165
Trypanosoma brucei beta tubulin 0.0783 0.4939 1
Schistosoma mansoni tubulin subunit alpha 0.0583 0.3652 0.4569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0138 0.08 0.1615
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0137 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.006 0.0109
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0016 0.0017 0.001
Brugia malayi Niemann-Pick C1 protein precursor 0.0191 0.1137 0.2299
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis eukaryotic initiation factor 4A 0.0024 0.0065 0.0059
Leishmania major hypothetical protein, conserved 0.0049 0.0226 0.0445
Schistosoma mansoni tyrosine kinase 0.0096 0.0531 0.0661
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0137 0.0918
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0121 0.0232
Schistosoma mansoni tyrosine kinase 0.0018 0.003 0.0033
Echinococcus granulosus epidermal growth factor receptor 0.0294 0.1798 0.3632
Onchocerca volvulus Putative organic anion transporter 0.0054 0.026 0.1719
Schistosoma mansoni Neurotrimin precursor (hNT) 0.002 0.0043 0.005
Loa Loa (eye worm) hypothetical protein 0.0583 0.3652 0.7394
Echinococcus granulosus neuropeptide s receptor 0.0458 0.2853 0.5771
Schistosoma mansoni integrin alpha-ps 0.0067 0.034 0.0422
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.0767
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0047 0.0212 0.0206
Onchocerca volvulus 0.0026 0.0081 0.0456
Leishmania major zeta tubulin, putative 0.0472 0.2942 0.5951
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0196 0.0384
Trypanosoma cruzi MFS transporter, putative 0.0054 0.026 0.0521
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0056 0.027 0.0334
Plasmodium vivax tubulin epsilon chain, putative 0.0464 0.2893 0.5857
Toxoplasma gondii Kazal-type serine protease inhibitor domain-containing protein 0.0037 0.015 0.0297
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.0767
Schistosoma mansoni agrin 0.0037 0.015 0.0184
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Schistosoma mansoni tyrosine kinase 0.016 0.0936 0.1168
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Entamoeba histolytica hypothetical protein 0.007 0.036 0.0729
Echinococcus granulosus Tubulin beta 2C chain 0.0783 0.4939 1
Echinococcus granulosus tubulin alpha chain 0.0583 0.3652 0.7392
Echinococcus granulosus tyrosine protein kinase Fyn 0.0047 0.0212 0.0417
Echinococcus multilocularis tubulin alpha chain 0.0583 0.3652 0.3648
Echinococcus multilocularis tubulin delta chain 0.0201 0.1201 0.1195
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0008
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1513 0.3055
Echinococcus multilocularis Tubulin beta 2C chain 0.0783 0.4939 0.4935
Brugia malayi Cathepsin L-like precursor 0.0016 0.0017 0.0029
Echinococcus multilocularis L aminoadipate semialdehyde 0.0161 0.0947 0.0941
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0226 0.0458
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Echinococcus multilocularis tyrosine protein kinase Blk 0.004 0.0171 0.0165
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi glutathione reductase 0.0046 0.0208 0.0415
Trichomonas vaginalis tubulin beta chain, putative 0.0583 0.3652 0.7392
Brugia malayi nuclear hormone receptor 0.0065 0.0331 0.0665
Echinococcus granulosus GPCR family 2 0.0015 0.001 0.0008
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Schistosoma mansoni zinc finger protein 0.0065 0.0331 0.041
Echinococcus multilocularis bloom syndrome protein 0.004 0.0169 0.0163
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0082
Loa Loa (eye worm) hypothetical protein 0.0048 0.0221 0.0443
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.0104 0.058 0.1171
Schistosoma mansoni nuclear receptor nhr-48 0.0065 0.0331 0.041
Onchocerca volvulus 0.0138 0.08 0.551
Schistosoma mansoni tubulin subunit beta 0.0783 0.4939 0.618
Schistosoma mansoni tubulin subunit beta 0.0201 0.1201 0.1499
Echinococcus multilocularis musashi 0.0026 0.0081 0.0074
Loa Loa (eye worm) tubulin alpha 2 0.0382 0.2364 0.4784
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Schistosoma mansoni tyrosine kinase 0.0018 0.003 0.0033
Trypanosoma cruzi alpha tubulin, putative 0.0583 0.3652 0.7393
Trypanosoma cruzi tubulin gamma chain 0.0465 0.2895 0.5859
Loa Loa (eye worm) tubulin beta chain 0.0783 0.4939 1
Entamoeba histolytica tubulin family protein 0.0783 0.4939 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Echinococcus multilocularis Tubulin alpha 1 chain 0.0583 0.3652 0.3648
Onchocerca volvulus Cathepsin F homolog 0.0016 0.0017 0.0007
Echinococcus multilocularis isocitrate dehydrogenase 0.0031 0.0109 0.0103
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0137 0.0918
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0016 0.0016 0.0027
Loa Loa (eye worm) hypothetical protein 0.0033 0.0124 0.0245
Leishmania major delta tubulin, putative 0.0363 0.2242 0.4532
Brugia malayi orphan nuclear receptor NR2E1 0.0065 0.0331 0.0665
Loa Loa (eye worm) tubulin beta-4 chain 0.0783 0.4939 1
Brugia malayi Tubulin beta chain 0.0201 0.1201 0.2427
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.006 0.0343
Echinococcus multilocularis cathepsin L cysteine protease 0.0016 0.0017 0.001
Echinococcus multilocularis basement membrane specific heparan sulfate 0.002 0.0043 0.0037
Trichomonas vaginalis tubulin beta chain, putative 0.0583 0.3652 0.7392
Loa Loa (eye worm) hypothetical protein 0.0065 0.0331 0.0665
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0324 0.0652
Trichomonas vaginalis tubulin epsilon chain, putative 0.0783 0.4939 1
Trichomonas vaginalis tubulin alpha chain, putative 0.0238 0.1438 0.2903
Schistosoma mansoni nuclear receptor 0.0065 0.0331 0.041
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus granulosus Niemann Pick C1 protein 0.0273 0.1663 0.3358
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0226 0.0445
Echinococcus granulosus tubulin gamma 1 chain 0.0465 0.2895 0.5857
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0081 0.0158
Schistosoma mansoni organic anion transporter 0.0054 0.026 0.0322
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0015 0.0017
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0092 0.018
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0324 0.0657
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0311 0.0617
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.014 0.0811 0.1011
Echinococcus multilocularis cpg binding protein 0.003 0.0102 0.0095
Plasmodium vivax tubulin alpha chain, putative 0.0583 0.3652 0.7395
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Schistosoma mansoni tyrosine kinase 0.0096 0.0531 0.0661
Brugia malayi AMP-binding enzyme family protein 0.0023 0.006 0.0117
Brugia malayi Protein kinase domain containing protein 0.0096 0.0531 0.1071
Brugia malayi eukaryotic initiation factor 4A 0.0024 0.0065 0.0127
Schistosoma mansoni DNA helicase recq5 0.0028 0.0091 0.011
Loa Loa (eye worm) hypothetical protein 0.0382 0.2364 0.4784
Schistosoma mansoni tubulin subunit epsilon 0.0464 0.2893 0.3618
Echinococcus granulosus integrin alpha 3 0.0114 0.0644 0.1293
Schistosoma mansoni survival motor neuron protein 0.0047 0.0213 0.0263
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0016 0.0017 0.0029
Loa Loa (eye worm) hypothetical protein 0.0191 0.1137 0.2299
Trypanosoma cruzi zeta tubulin, putative 0.0472 0.2942 0.5953
Echinococcus granulosus eukaryotic initiation factor 4A III 0.0024 0.0065 0.0119
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0324 0.0645
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0221 0.0443
Trypanosoma brucei alpha tubulin 0.0583 0.3652 0.7392
Echinococcus multilocularis cysteine protease 0.0016 0.0017 0.001
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Echinococcus granulosus eukaryotic initiation factor 4A 0.0024 0.0065 0.0119
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.006 0.0122
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0044 0.0193 0.0378
Schistosoma mansoni blooms syndrome DNA helicase 0.0026 0.0078 0.0094
Trypanosoma brucei tubulin delta chain 0.0363 0.2242 0.4532
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0213 0.1276 0.1271
Schistosoma mansoni hypothetical protein 0.0022 0.0053 0.0062
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0015 0.0023
Echinococcus multilocularis tubulin alpha 0.0439 0.2727 0.2722
Echinococcus granulosus defective proboscis extension response 0.002 0.0043 0.0074
Loa Loa (eye worm) hypothetical protein 0.0026 0.0081 0.0158
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Brugia malayi sodium-independent organic anion transporter family protein 0.0054 0.026 0.0522
Trichomonas vaginalis tubulin alpha chain, putative 0.0783 0.4939 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0053 0.0047
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0331 0.0658
Giardia lamblia Sgs1 DNA helicase, putative 0.0028 0.0091 0.0155
Treponema pallidum ATP-dependent RNA helicase 0.0024 0.0065 0.0514
Echinococcus granulosus tyrosine protein kinase Lyn 0.0047 0.0212 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0017 0.0017
Trichomonas vaginalis tubulin beta chain, putative 0.0238 0.1438 0.2903
Loa Loa (eye worm) hypothetical protein 0.0082 0.0439 0.0884
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0064 0.0116
Echinococcus granulosus Immunoglobulin 0.002 0.0043 0.0074
Mycobacterium ulcerans putative regulatory protein 0.0035 0.0137 0.1032
Toxoplasma gondii beta-tubulin, putative 0.0783 0.4939 1
Echinococcus granulosus lamin dm0 0.0026 0.0081 0.0151
Plasmodium falciparum tubulin epsilon chain, putative 0.0464 0.2893 0.5845
Schistosoma mansoni integrin beta subunit 0.0179 0.1063 0.1327
Brugia malayi beta-lactamase 0.0035 0.0137 0.0273
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0081 0.0158
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0016 0.0016 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0138 0.08 0.1615
Schistosoma mansoni hypothetical protein 0.0329 0.202 0.2526
Brugia malayi Kazal-type serine protease inhibitor domain containing protein 0.0037 0.015 0.0299
Brugia malayi Tubulin alpha chain 0.0583 0.3652 0.7394
Schistosoma mansoni thyroid hormone receptor 0.0261 0.1585 0.1981
Brugia malayi isocitrate dehydrogenase 0.0031 0.0109 0.0216
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0016 0.0017 0.0021
Brugia malayi Immunoglobulin I-set domain containing protein 0.0023 0.0061 0.0118
Schistosoma mansoni intermediate filament proteins 0.0026 0.0081 0.0097
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.006 0.0122
Trypanosoma brucei epsilon tubulin 0.0464 0.2893 0.5852
Schistosoma mansoni tubulin subunit alpha 0.0201 0.1201 0.1499
Trypanosoma brucei beta tubulin 0.0439 0.2727 0.5515
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0196 0.0241
Plasmodium vivax vivapain-2 0.0016 0.0017 0.0034
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0017 0.0034
Brugia malayi Integrin alpha pat-2 precursor 0.0149 0.0867 0.1751
Schistosoma mansoni DEAD box ATP-dependent RNA helicase 0.0024 0.0065 0.0077
Schistosoma mansoni hypothetical protein 0.007 0.036 0.0446
Schistosoma mansoni nephrin 0.0026 0.008 0.0095
Brugia malayi MH2 domain containing protein 0.0016 0.0014 0.0022
Brugia malayi nuclear receptor NHR-88 0.0065 0.0331 0.0665
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0053 0.0094
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0023 0.044
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0138 0.08 0.1615
Loa Loa (eye worm) hypothetical protein 0.0073 0.0381 0.0767
Echinococcus multilocularis tubulin alpha 1C chain 0.0583 0.3652 0.3648
Schistosoma mansoni hypothetical protein 0.0122 0.0698 0.087
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0143 0.0137
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0273
Onchocerca volvulus 0.0035 0.0137 0.0852
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0047 0.0212 0.0206
Echinococcus multilocularis tubulin gamma 1 chain 0.0465 0.2895 0.2891
Mycobacterium ulcerans hypothetical protein 0.0023 0.006 0.0385
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0135 0.0262
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Loa Loa (eye worm) steroid hormone receptor 0.0138 0.08 0.1615
Onchocerca volvulus 0.0035 0.0137 0.0852
Loa Loa (eye worm) hypothetical protein 0.0036 0.0143 0.0285
Echinococcus granulosus cathepsin l cysteine peptidase 0.0016 0.0017 0.0021
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0056 0.027 0.0535
Plasmodium falciparum alpha tubulin 2 0.0583 0.3652 0.7387
Trypanosoma brucei alpha tubulin 0.0583 0.3652 0.7392
Trichomonas vaginalis tubulin epsilon chain, putative 0.0783 0.4939 1
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0382 0.2364 0.478
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0014 0.0014
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0698 0.0692
Echinococcus granulosus integrin alpha ps 0.0032 0.0117 0.0225
Brugia malayi hypothetical protein 0.0023 0.0061 0.0118
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Trichomonas vaginalis DNA helicase recq, putative 0.003 0.0107 0.0204
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0008
Trichomonas vaginalis tubulin gamma chain, putative 0.0465 0.2895 0.5857
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.006 0.0385
Echinococcus multilocularis lamin dm0 0.0026 0.0081 0.0074
Loa Loa (eye worm) hypothetical protein 0.0138 0.08 0.1615
Echinococcus multilocularis Immunoglobulin 0.002 0.0043 0.0037
Echinococcus multilocularis tyrosine protein kinase Srms 0.004 0.0171 0.0165
Trypanosoma brucei alpha tubulin 0.0583 0.3652 0.7392
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis expressed protein 0.0037 0.015 0.0144
Echinococcus granulosus tubulin alpha 1C chain 0.0583 0.3652 0.7392
Brugia malayi Fibronectin type III domain containing protein 0.0023 0.0061 0.0118
Loa Loa (eye worm) ctsf protein 0.0016 0.0017 0.0029
Trichomonas vaginalis DNA helicase recq, putative 0.004 0.0169 0.033
Echinococcus granulosus lamin 0.0026 0.0081 0.0151
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0149
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0056 0.027 0.2157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0138 0.08 0.1608
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0047 0.0212 0.0206
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0196 0.0241
Leishmania major cathepsin L-like protease 0.0016 0.0017 0.0021
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0016 0.0017 0.0021
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0015 0.0006 0.0004
Echinococcus granulosus cpg binding protein 0.003 0.0102 0.0193
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0143 0.0283
Loa Loa (eye worm) phosphatidylinositol 3 0.0044 0.0193 0.0386
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0065 0.0331 0.2215
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0138 0.08 0.551
Loa Loa (eye worm) tubulin alpha 2 0.0382 0.2364 0.4784
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0031 0.0109 0.0103
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Loa Loa (eye worm) hypothetical protein 0.0035 0.0137 0.0273
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0138 0.08 0.0794
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0138 0.08 0.0997
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0044 0.0193 0.0378
Plasmodium falciparum glutathione reductase 0.0046 0.0208 0.0392
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0023 0.007
Trichomonas vaginalis esterase, putative 0.0035 0.0137 0.0265
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0138 0.08 0.0794
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0194 0.1156 0.1443
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0138 0.08 0.1615
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0065 0.0331 0.041
Schistosoma mansoni tyrosine kinase 0.0154 0.0902 0.1125
Brugia malayi intermediate filament protein 0.0026 0.0081 0.0158
Toxoplasma gondii alpha-tubulin I, putative 0.0583 0.3652 0.7393
Echinococcus multilocularis ecdysone induced protein 78C 0.0138 0.08 0.0794
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0238 0.1438 0.2903
Echinococcus granulosus Nuclear hormone receptor HR96 0.0065 0.0331 0.0658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.008 0.0149
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0008
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0028 0.0091 0.0155
Echinococcus granulosus thyroid hormone receptor alpha 0.0065 0.0331 0.0658
Loa Loa (eye worm) hypothetical protein 0.0023 0.006 0.0117
Trypanosoma brucei epsilon tubulin 0.0439 0.2727 0.5515
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0127
Brugia malayi Nuclear hormone receptor E75 0.0065 0.0331 0.0665
Toxoplasma gondii ABC1 family protein 0.0035 0.0137 0.0271
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0161 0.0946 0.094
Trichomonas vaginalis tubulin beta chain, putative 0.0583 0.3652 0.7392
Echinococcus granulosus Tubulin beta 2C chain 0.0783 0.4939 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0661 0.4845
Echinococcus multilocularis beta tubulin 0.0783 0.4939 0.4935
Brugia malayi Tyrosine-protein kinase abl-1 0.0124 0.0707 0.1428
Trichomonas vaginalis tubulin alpha chain, putative 0.0439 0.2727 0.5515
Echinococcus granulosus ecdysone induced protein 78C 0.0138 0.08 0.1608
Schistosoma mansoni tubulin subunit alpha 0.0583 0.3652 0.4569
Echinococcus granulosus tubulin alpha 0.0439 0.2727 0.5515
Echinococcus multilocularis tubulin alpha chain 0.0583 0.3652 0.3648
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0015 0.0006 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0101 0.0191
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0137 0.0673
Echinococcus multilocularis lamin 0.0026 0.0081 0.0074
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0014 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0265
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0044 0.0193 0.0378
Brugia malayi beta-tubulin, identical 0.0783 0.4939 1
Echinococcus multilocularis eukaryotic initiation factor 4A III 0.0024 0.0065 0.0059
Echinococcus multilocularis protein patched 0.0082 0.0438 0.0432
Trichomonas vaginalis DEAD box ATP-dependent RNA helicase, putative 0.0024 0.0065 0.0119
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0138 0.08 0.0794
Trichomonas vaginalis glucosylceramidase, putative 0.0249 0.1513 0.3055
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0031 0.0109 0.0214
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0143 0.0285
Plasmodium vivax tubulin beta chain, putative 0.0783 0.4939 1
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0035 0.0137 0.013
Echinococcus multilocularis Tubulin beta 2C chain 0.0783 0.4939 0.4935
Trichomonas vaginalis PIKK family atypical protein kinase 0.0044 0.0193 0.0378
Echinococcus multilocularis Immunoglobulin 0.002 0.0043 0.0037
Leishmania major alpha tubulin 0.0583 0.3652 0.7392
Brugia malayi Tyrosine-protein kinase abl-1 0.0095 0.0522 0.1053
Brugia malayi beta-lactamase family protein 0.0035 0.0137 0.0273
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0138 0.08 0.0794
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0225 0.045
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0151 0.0145
Onchocerca volvulus 0.0016 0.0017 0.0007
Mycobacterium leprae Probable lipase LipE 0.0035 0.0137 0.0673
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0226 0.0451
Giardia lamblia Beta tubulin 0.0783 0.4939 1
Loa Loa (eye worm) hypothetical protein 0.0054 0.026 0.0522
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0041 0.0177 0.0351
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0073 0.0381 0.0767
Onchocerca volvulus 0.0054 0.026 0.1719
Schistosoma mansoni DNA helicase recq1 0.0028 0.0091 0.011
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0082 0.0438 0.0882
Entamoeba histolytica cysteine proteinase, putative 0.0016 0.0017 0.0034
Trichomonas vaginalis tubulin alpha chain, putative 0.0238 0.1438 0.2903
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0137 0.0265
Schistosoma mansoni hypothetical protein 0.0015 0.001 0.0008
Giardia lamblia Translation initiation factor eIF-4A, putative 0.0024 0.0065 0.0102
Trichomonas vaginalis tubulin epsilon chain, putative 0.0583 0.3652 0.7392
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0234 0.1415 0.2856
Brugia malayi MH1 domain containing protein 0.0016 0.0014 0.0022
Trichomonas vaginalis glucosylceramidase, putative 0.0164 0.0963 0.1939
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0017 0.0029
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0345 0.2126 0.4298
Echinococcus granulosus Tubulin alpha 1 chain 0.0583 0.3652 0.7392
Echinococcus granulosus follistatin 0.0037 0.015 0.0291
Leishmania major beta tubulin 0.0783 0.4939 1
Leishmania major beta tubulin 0.0783 0.4939 1
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0099 0.0549 0.0543
Onchocerca volvulus 0.0028 0.0092 0.0532
Schistosoma mansoni tyrosine kinase 0.0101 0.0562 0.0699
Loa Loa (eye worm) agrin synaptic family protein 0.0037 0.015 0.0299
Schistosoma mansoni retinoic acid receptor RXR 0.0234 0.1415 0.1767
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1348 1
Schistosoma mansoni tubulin subunit beta 0.0783 0.4939 0.618
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0324 0.0402
Brugia malayi hypothetical protein 0.0073 0.0381 0.0767
Echinococcus multilocularis Tubulin alpha 1 chain 0.0583 0.3652 0.3648
Loa Loa (eye worm) hypothetical protein 0.0037 0.015 0.0299
Loa Loa (eye worm) nuclear receptor NHR-67 0.0065 0.0331 0.0665
Schistosoma mansoni patched 1 0.0082 0.0438 0.0544
Echinococcus granulosus integrin alpha ps 0.0067 0.034 0.0677

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) 0 Anticoagulant activity in human plasma assessed as concentration required to double prothrombin time ChEMBL. 17588746
Ki (binding) = 4.8 nM Inhibition of human factor 10a ChEMBL. 17588746
Ki (binding) = 4.8 nM Inhibition of human factor 10a ChEMBL. 17588746

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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