Detailed information for compound 579904

Basic information

Technical information
  • TDR Targets ID: 579904
  • Name: bis(3'-5')cyclic diuridine monophosphate
  • MW: 612.332 | Formula: C18H22N4O16P2
  • H donors: 6 H acceptors: 10 LogP: -5.91 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 3
  • SMILES: O[C@@H]1[C@@H]2OP(=O)(O)OC[C@H]3O[C@H]([C@@H]([C@@H]3OP(=O)(OC[C@H]2O[C@H]1n1ccc(=O)[nH]c1=O)O)O)n1ccc(=O)[nH]c1=O
  • InChi: 1S/C18H22N4O16P2/c23-9-1-3-21(17(27)19-9)15-11(25)13-7(35-15)5-33-40(31,32)38-14-8(6-34-39(29,30)37-13)36-16(12(14)26)22-4-2-10(24)20-18(22)28/h1-4,7-8,11-16,25-26H,5-6H2,(H,29,30)(H,31,32)(H,19,23,27)(H,20,24,28)/t7-,8-,11-,12-,13-,14-,15-,16-/m1/s1
  • InChiKey: ADHSUZMEJHOWOL-NCOIDOBVSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 73120-97-5
  • Cyclic bis((3'-5')uridylic acid)
  • Cyclo(uridylyl-(3'-5')uridine monophosphate)
  • Cyclo-upup
  • 3'-Uridylic acid, uridylyl-(3'-5')-, cyclic nucleotide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0225 0.1481 0.1897
Loa Loa (eye worm) hypothetical protein 0.0225 0.1481 0.1897
Echinococcus multilocularis lamin 0.0027 0.0093 0.0082
Schistosoma mansoni hypothetical protein 0.0051 0.0256 0.0391
Brugia malayi Inositol-1 0.0039 0.0176 0.0226
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0176 0.0396
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0224 0.0287
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0126 0.0115
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0176 0.021
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.006 0.105
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0293 0.0361
Schistosoma mansoni smad1 5 8 and 0.0018 0.0029 0.0028
Loa Loa (eye worm) MBCTL1 0.0054 0.0277 0.0355
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0318 0.049
Echinococcus granulosus cpg binding protein 0.0032 0.0123 0.0112
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0637 0.2704
Entamoeba histolytica hypothetical protein 0.0024 0.0069 0.0038
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.0327 0.2195 0.2799
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.001
Loa Loa (eye worm) jmjC domain-containing protein 0.0043 0.0199 0.0255
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.016 0.026
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0224 0.0214
Schistosoma mansoni ap endonuclease 0.0037 0.016 0.0237
Leishmania major basic transcription factor 3a, putative 0.0038 0.0165 0.0196
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0019 0.0033 0.0021
Loa Loa (eye worm) hypothetical protein 0.0225 0.1481 0.1897
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.006 0.0061
Mycobacterium ulcerans lipase LipD 0.0225 0.1481 0.1884
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0272 0.026
Toxoplasma gondii hypothetical protein 0.0027 0.009 0.0355
Schistosoma mansoni lamin 0.0027 0.0093 0.013
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0225 0.1481 0.1471
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.012
Onchocerca volvulus Glucosylceramidase homolog 0.0183 0.1183 0.3534
Toxoplasma gondii exonuclease III APE 0.0037 0.016 0.0677
Brugia malayi mbt repeat family protein 0.0047 0.0231 0.0296
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0054 0.0277 0.0355
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0022 0.0046
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0278 0.1856 0.2376
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.0327 0.2195 0.2185
Schistosoma mansoni hypothetical protein 0.0903 0.6244 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0451 0.0704
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0054 0.0277 0.0268
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.008 0.0087
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0225 0.1481 0.2357
Loa Loa (eye worm) hypothetical protein 0.0051 0.0256 0.0328
Loa Loa (eye worm) hypothetical protein 0.0054 0.0277 0.0355
Schistosoma mansoni alpha-glucosidase 0.0142 0.0899 0.1423
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0012 0.0016
Echinococcus granulosus importin subunit beta 1 0.003 0.0108 0.0097
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.016 0.0205
Loa Loa (eye worm) hypothetical protein 0.0081 0.0468 0.06
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0158 0.0667
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.016 0.1006
Leishmania major GTP-binding protein, putative 0.0022 0.0053 0.0053
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Leishmania major cytochrome p450-like protein 0.1126 0.7809 1
Echinococcus granulosus geminin 0.0903 0.6244 0.6299
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.4615 0.4652
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0231 0.0296
Schistosoma mansoni hypothetical protein 0.0145 0.0918 0.1454
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0078 0.0451 0.0704
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0158 0.0202
Brugia malayi PHD-finger family protein 0.0032 0.0126 0.0161
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.006 0.0115
Echinococcus multilocularis zinc finger protein 0.0023 0.0064 0.0052
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0096 0.0202
Brugia malayi jmjC domain containing protein 0.0105 0.0638 0.0817
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0332 0.0513
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.006 0.0325
Echinococcus granulosus dnaJ subfamily B 0.0398 0.2695 0.2712
Mycobacterium tuberculosis Probable hydrolase 0.0225 0.1481 0.1471
Echinococcus multilocularis aurora kinase A 0.0069 0.0385 0.0377
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1061 0.106
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0165 0.0196
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.006 0.105
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0051 0.0256 0.0246
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.006 0.0219
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0224 0.0214
Loa Loa (eye worm) hypothetical protein 0.0109 0.0669 0.0856
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0176 0.021
Brugia malayi Bromodomain containing protein 0.0085 0.0496 0.0635
Trypanosoma brucei ISWI complex protein 0.0017 0.0019 0.0009
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0165 0.0369
Brugia malayi MH1 domain containing protein 0.0018 0.0029 0.0038
Brugia malayi Calcitonin receptor-like protein seb-1 0.016 0.1025 0.1312
Schistosoma mansoni inositol monophosphatase 0.0039 0.0176 0.0263
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.0327 0.2195 0.2185
Loa Loa (eye worm) hypothetical protein 0.0225 0.1481 0.1897
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0004 0.0005
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.008 0.031
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0468 0.06
Toxoplasma gondii ABC1 family protein 0.0225 0.1481 0.673
Schistosoma mansoni lamin 0.0027 0.0093 0.013
Loa Loa (eye worm) hypothetical protein 0.0225 0.1481 0.1897
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.0327 0.2195 0.2799
Echinococcus multilocularis 0.0327 0.2195 0.2206
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0199 0.03
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0193 0.1257 0.1258
Echinococcus multilocularis dnaJ subfamily B 0.0398 0.2695 0.2712
Echinococcus multilocularis thyroid hormone receptor alpha 0.0157 0.1 0.0998
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0022 0.0013
Schistosoma mansoni smad 0.0018 0.0029 0.0028
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0022 0.0069
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0176 0.0751
Echinococcus granulosus Smad4 0.0018 0.0029 0.0017
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0468 0.0732
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0126 0.0115
Trichomonas vaginalis ran, putative 0.0022 0.0053 0.0099
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0986 0.1249
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0272 0.0263
Entamoeba histolytica hypothetical protein 0.0151 0.0964 0.2221
Trichomonas vaginalis penicillin-binding protein, putative 0.0225 0.1481 0.3546
Trypanosoma brucei glucosidase, putative 0.0037 0.0158 0.0187
Brugia malayi hypothetical protein 0.0027 0.009 0.0115
Trypanosoma brucei hypothetical protein, conserved 0.0225 0.1481 0.1884
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0093 0.012
Schistosoma mansoni bromodomain containing protein 0.0072 0.0404 0.0629
Mycobacterium leprae putative cytochrome p450 0.0327 0.2195 1
Schistosoma mansoni hypothetical protein 0.0294 0.1965 0.3133
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.0327 0.2195 0.2799
Brugia malayi beta-lactamase family protein 0.0225 0.1481 0.1897
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0053 0.0053
Echinococcus multilocularis neuropeptide s receptor 0.0516 0.3527 0.3553
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0097 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0018 0.0029 0.0038
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.016 0.0357
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0069 0.0073
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0027 0.0087 0.0076
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.0327 0.2195 0.2799
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.0165 0.104
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.0777 0.3503
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0158 0.0147
Echinococcus granulosus mothers against decapentaplegic 5 0.0018 0.0029 0.0017
Plasmodium vivax glutathione reductase, putative 0.0046 0.0223 0.1437
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.1481 0.3546
Schistosoma mansoni importin beta-1 0.003 0.0108 0.0154
Trypanosoma brucei cytochrome P450, putative 0.1126 0.7809 1
Onchocerca volvulus 0.0027 0.0093 0.0012
Schistosoma mansoni alpha-glucosidase 0.0142 0.0899 0.1423
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0231 0.0221
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.0327 0.2195 0.2185
Brugia malayi Protein kinase domain containing protein 0.0088 0.0519 0.0664
Schistosoma mansoni hypothetical protein 0.0109 0.0669 0.1054
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1252 0.2993
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0158 0.0255
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.018 0.017
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0069 0.0385 0.0808
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0223 0.0213
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.0327 0.2195 0.2799
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0147 0.0409
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0351
Schistosoma mansoni hypothetical protein 0.0316 0.2119 0.3381
Schistosoma mansoni cytochrome P450 0.0327 0.2195 0.3502
Trypanosoma cruzi ISWI complex protein 0.0017 0.0019 0.0009
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0377 0.0368
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0637 0.0626
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0033 0.0034
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.1126 0.7809 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0606 0.4155 1
Toxoplasma gondii hypothetical protein 0.0053 0.027 0.1182
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0224 0.0214
Schistosoma mansoni hypothetical protein 0.0051 0.0256 0.0391
Loa Loa (eye worm) MH1 domain-containing protein 0.0018 0.0029 0.0038
Leishmania major importin beta-1 subunit, putative 0.0024 0.0069 0.0073
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0225 0.1481 0.1884
Schistosoma mansoni cpg binding protein 0.0028 0.0097 0.0135
Entamoeba histolytica hypothetical protein 0.0038 0.0165 0.0272
Echinococcus granulosus methyl CpG binding domain protein 2 0.0019 0.0033 0.0021
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0272 0.026
Echinococcus granulosus smad 0.0018 0.0029 0.0017
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0223 0.0286
Schistosoma mansoni ran 0.0022 0.0053 0.0066
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.1481 0.3546
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0053 0.0053
Trypanosoma brucei trypanothione reductase 0.0046 0.0223 0.0271
Loa Loa (eye worm) cytochrome P450 family protein 0.1126 0.7809 1
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.0327 0.2195 0.2185
Echinococcus multilocularis smad 0.0018 0.0029 0.0017
Echinococcus multilocularis jumonji domain containing protein 0.0045 0.0214 0.0204
Mycobacterium ulcerans hypothetical protein 0.0225 0.1481 0.1884
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.016 0.3244
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.016 0.0189
Schistosoma mansoni smad1 5 8 and 0.0018 0.0029 0.0028
Brugia malayi F/Y-rich N-terminus family protein 0.0023 0.0064 0.0082
Echinococcus granulosus aurora kinase A 0.0069 0.0385 0.0377
Brugia malayi MH2 domain containing protein 0.0018 0.0029 0.0038
Echinococcus granulosus tumor protein p63 0.1424 0.9905 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0022 0.0222
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0365 0.0468
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0296 0.1979 0.2522
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.1481 0.1884
Brugia malayi serine/threonine kinase 12 0.0069 0.0385 0.0493
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0058 0.0306 0.1344
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.008 0.1484
Brugia malayi Bromodomain containing protein 0.0042 0.0199 0.0254
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0081 0.0468 0.046
Leishmania major protein kinase, putative 0.0069 0.0385 0.0478
Schistosoma mansoni protein kinase 0.0069 0.0385 0.0598
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0099
Giardia lamblia Aurora kinase 0.0069 0.0385 0.0899
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.0327 0.2195 0.2799
Plasmodium vivax importin-beta 2, putative 0.003 0.0108 0.0653
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0069 0.0137
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.0777 0.0773
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0069 0.0385 0.0808
Echinococcus multilocularis geminin 0.0903 0.6244 0.6299
Loa Loa (eye worm) TTK protein kinase 0.0088 0.0519 0.0664
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0296 0.1979 0.1969
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0468 0.2087
Brugia malayi Cytochrome P450 family protein 0.0327 0.2195 0.281
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.001
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0051 0.0256 0.0328
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0223 0.0211
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0022 0.0013
Toxoplasma gondii aurora kinase 0.0069 0.0385 0.1707
Schistosoma mansoni cpg binding protein 0.0032 0.0123 0.0177
Trypanosoma brucei aurora B kinase 0.0069 0.0385 0.0478
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0176 0.0166
Schistosoma mansoni hypothetical protein 0.0023 0.0061 0.0078
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0078 0.0451 0.0443
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Brugia malayi MH2 domain containing protein 0.027 0.1796 0.2299
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.0327 0.2195 0.2185
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1856 0.4449
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.016 0.0149
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.0327 0.2195 0.2185
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.0719 0.0708
Loa Loa (eye worm) hypothetical protein 0.0078 0.0451 0.0577
Brugia malayi intermediate filament protein 0.0027 0.0093 0.012
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0115
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0158 0.0147
Brugia malayi hypothetical protein 0.0384 0.2597 0.3326
Plasmodium falciparum thioredoxin reductase 0.0046 0.0223 0.4636
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0385 0.0899
Schistosoma mansoni cpg binding protein 0.0032 0.0123 0.0177
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.0327 0.2195 0.2799
Trichomonas vaginalis D-aminoacylase, putative 0.0225 0.1481 0.3546
Onchocerca volvulus 0.0047 0.0231 0.0457
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0231 0.0351
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0108 0.0123
Loa Loa (eye worm) hypothetical protein 0.016 0.1025 0.1312
Loa Loa (eye worm) hypothetical protein 0.0027 0.009 0.0115
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0027 0.0087 0.012
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.0088 0.0519 0.1387
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0022 0.0013
Loa Loa (eye worm) MH2 domain-containing protein 0.027 0.1796 0.2299
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.0986 0.1249
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0223 0.027
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.0777 0.0773
Trypanosoma cruzi aurora B kinase, putative 0.0069 0.0385 0.0478
Brugia malayi beta-lactamase 0.0225 0.1481 0.1897
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1856 0.4449
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0151 0.0964 0.0962
Schistosoma mansoni mixed-lineage leukemia protein mll 0.002 0.0038 0.0041
Echinococcus multilocularis lysosomal alpha glucosidase 0.0165 0.1061 0.106
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0145 0.0918 0.0916
Onchocerca volvulus 0.0096 0.0571 0.1557
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.0327 0.2195 0.2799
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0351
Loa Loa (eye worm) hypothetical protein 0.0043 0.0199 0.0255
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0637 0.0626
Loa Loa (eye worm) CYP4Cod1 0.1126 0.7809 1
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0069 0.0137
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.0327 0.2195 0.2799
Schistosoma mansoni transcription factor LCR-F1 0.0151 0.0964 0.1528
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.0327 0.2195 0.2185
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.016 0.0357
Loa Loa (eye worm) cytochrome P450 family protein 0.1126 0.7809 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0027 0.009 0.1702
Echinococcus granulosus intermediate filament protein 0.0027 0.0093 0.0082
Brugia malayi Cytochrome P450 family protein 0.1126 0.7809 1
Schistosoma mansoni hypothetical protein 0.0398 0.2695 0.4304
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0327 0.2195 0.2799
Giardia lamblia Fructose-bisphosphate aldolase 0.0606 0.4155 1
Schistosoma mansoni alpha glucosidase 0.0037 0.0158 0.0234
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.2194 0.2798
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 1
Loa Loa (eye worm) hypothetical protein 0.0208 0.1365 0.1748
Leishmania major hypothetical protein, conserved 0.0225 0.1481 0.1884
Loa Loa (eye worm) hypothetical protein 0.0225 0.1481 0.1897
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0519 0.1223
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Trichomonas vaginalis glucosylceramidase, putative 0.0192 0.1252 0.2993
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0223 0.0271
Onchocerca volvulus 0.0028 0.0097 0.0022
Loa Loa (eye worm) hypothetical protein 0.0047 0.0231 0.0296
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 0.0584
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0165 0.0369
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0108 0.044
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0316 0.2119 0.2714
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0225 0.1481 0.2357
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.016 0.0148
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0022 0.001
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.0777 0.098
Loa Loa (eye worm) pigment dispersing factor receptor c 0.016 0.1025 0.1312
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0296 0.1979 0.8989
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.016 0.0189
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0158 0.0351
Trichomonas vaginalis CAMK family protein kinase 0.0088 0.0519 0.1223
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.0327 0.2195 0.2799
Echinococcus multilocularis histone acetyltransferase MYST2 0.0054 0.0277 0.0268
Plasmodium falciparum glutathione reductase 0.0046 0.0223 0.4636
Schistosoma mansoni hypothetical protein 0.0051 0.0256 0.0391
Loa Loa (eye worm) hypothetical protein 0.0026 0.008 0.0102
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0068
Brugia malayi MH2 domain containing protein 0.0018 0.0029 0.0038
Schistosoma mansoni hypothetical protein 0.0151 0.0964 0.1528
Brugia malayi Bromodomain containing protein 0.0035 0.0144 0.0184
Brugia malayi glutathione reductase 0.0046 0.0223 0.0286
Loa Loa (eye worm) hypothetical protein 0.0225 0.1481 0.1897
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0053 0.0053
Leishmania major trypanothione reductase 0.0046 0.0223 0.0271
Schistosoma mansoni thyroid hormone receptor 0.0157 0.1 0.1585
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0788 0.544 0.5487
Echinococcus granulosus histone lysine methyltransferase setb 0.0078 0.0451 0.0443
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0223 0.027
Onchocerca volvulus 0.0225 0.1481 0.4497
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0176 0.03
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.0327 0.2195 0.2185
Brugia malayi latrophilin 2 splice variant baaae 0.0109 0.0669 0.0856
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0224 0.0339
Loa Loa (eye worm) latrophilin receptor protein 2 0.0051 0.0256 0.0328
Onchocerca volvulus Alhambra homolog 0.0032 0.0126 0.0116
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0165 0.1061 0.1358
Schistosoma mansoni Smad4 0.0018 0.0029 0.0028
Echinococcus multilocularis lysine specific demethylase 5A 0.0039 0.0173 0.0162
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0176 0.021
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.0327 0.2195 0.2799
Loa Loa (eye worm) ICD-1 protein 0.0038 0.0165 0.0211
Loa Loa (eye worm) hypothetical protein 0.0384 0.2597 0.3326
Schistosoma mansoni smad1 5 8 and 0.0018 0.0029 0.0028
Schistosoma mansoni methyl-cpg binding protein mbd 0.0019 0.0033 0.0034
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.006 0.0061
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0176 0.0396
Loa Loa (eye worm) hypothetical protein 0.0799 0.5515 0.7062
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0637 0.0626
Loa Loa (eye worm) hypothetical protein 0.0078 0.0451 0.0578
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0158 0.0255
Trypanosoma cruzi cytochrome P450, putative 0.1126 0.7809 1
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0105 0.0638 0.0633
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0126 0.0161
Onchocerca volvulus 0.0225 0.1481 0.4497
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0022 0.0016
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0272 0.0263
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.0165 0.0272
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0081 0.0468 0.2087
Schistosoma mansoni intermediate filament proteins 0.0027 0.0093 0.013
Loa Loa (eye worm) hypothetical protein 0.003 0.0108 0.0139
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0327 0.2195 0.2799
Echinococcus multilocularis musashi 0.0027 0.0093 0.0082
Plasmodium falciparum serine/threonine protein kinase, putative 0.0069 0.0385 0.8182
Toxoplasma gondii thioredoxin reductase 0.0046 0.0223 0.0967
Echinococcus granulosus microtubule associated protein 2 0.0671 0.4615 0.4652
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.008 0.1484
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0385 0.0493
Brugia malayi isocitrate dehydrogenase 0.0017 0.0022 0.0029
Brugia malayi beta-lactamase family protein 0.0225 0.1481 0.1897
Echinococcus multilocularis Smad4 0.0018 0.0029 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Brugia malayi hypothetical protein 0.0026 0.008 0.0102
Brugia malayi hypothetical protein 0.0151 0.0964 0.1235
Schistosoma mansoni zinc finger protein 0.0023 0.0064 0.0083
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.0327 0.2195 0.2185
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.0777 0.0765
Trypanosoma cruzi ISWI complex protein 0.0017 0.0019 0.0009
Plasmodium vivax hypothetical protein, conserved 0.0027 0.009 0.0528
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0069 0.0137
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0093 0.012
Mycobacterium ulcerans hypothetical protein 0.0172 0.1108 0.1406
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0326 0.2194 0.2798
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0385 0.0899
Mycobacterium leprae Conserved hypothetical protein 0.0327 0.2195 1
Echinococcus granulosus jumonji domain containing protein 0.0045 0.0214 0.0204
Loa Loa (eye worm) hypothetical protein 0.0055 0.0286 0.0367
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0053 0.0041
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.016 0.0357
Mycobacterium leprae conserved hypothetical protein 0.0225 0.1481 0.6657
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0225 0.1481 0.1471
Echinococcus granulosus neuropeptide receptor A26 0.0516 0.3527 0.3553
Leishmania major hypothetical protein, conserved 0.0026 0.008 0.0087
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0499 0.341 0.4366
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.016 0.0357
Mycobacterium tuberculosis Probable lipase LipE 0.0225 0.1481 0.1471
Giardia lamblia PHD finger protein 15 0.0032 0.0126 0.0274
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.0327 0.2195 0.2185
Leishmania major hypothetical protein, conserved 0.0017 0.0019 0.0009
Loa Loa (eye worm) transcription factor SMAD2 0.027 0.1796 0.2299
Echinococcus multilocularis beta LACTamase domain containing family member 0.0225 0.1481 0.1485
Loa Loa (eye worm) glutathione reductase 0.0046 0.0223 0.0286
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1856 0.4449
Brugia malayi hypothetical protein 0.0016 0.0016 0.0021
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 1
Entamoeba histolytica protein kinase , putative 0.0069 0.0385 0.0808
Schistosoma mansoni peptidase Clp (S14 family) 0.0081 0.0468 0.0731
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0061 0.0078
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0176 0.021
Brugia malayi Cytochrome P450 family protein 0.1126 0.7809 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0231 0.0221
Onchocerca volvulus 0.0027 0.0093 0.0012
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.0327 0.2195 0.2799
Entamoeba histolytica hypothetical protein 0.0151 0.0964 0.2221
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.016 0.0149
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0377 0.0368
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0777 0.098
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0223 0.0213
Brugia malayi PHD-finger family protein 0.0029 0.0106 0.0135
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0637 0.0626
Toxoplasma gondii cytochrome p450 superfamily protein 0.0327 0.2195 1
Brugia malayi Pre-SET motif family protein 0.0059 0.0318 0.0407
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0326 0.2194 0.2798
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0126 0.0771
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0096 0.0167
Toxoplasma gondii hypothetical protein 0.0028 0.0096 0.0383
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.0327 0.2195 0.2185
Brugia malayi Probable ClpP-like protease 0.0081 0.0468 0.0599
Echinococcus granulosus lysine specific demethylase 5A 0.0043 0.0199 0.0189
Plasmodium falciparum phd finger protein, putative 0.0032 0.0126 0.2488
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0018 0.0029 0.0017
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0022 0.0029
Mycobacterium leprae Probable lipase LipE 0.0225 0.1481 0.6657
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0022 0.0013
Brugia malayi Pre-SET motif family protein 0.0411 0.2786 0.3567
Schistosoma mansoni cellular tumor antigen P53 0.0208 0.1365 0.217
Loa Loa (eye worm) cytochrome P450 0.0327 0.2195 0.281
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0158 0.0187
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0223 0.1437
Plasmodium vivax SET domain protein, putative 0.0059 0.0318 0.208
Loa Loa (eye worm) Smad1 0.0018 0.0029 0.0038
Echinococcus multilocularis importin subunit beta 1 0.003 0.0108 0.0097
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.0327 0.2195 0.2185
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0022 0.0013
Echinococcus multilocularis snurportin 1 0.0316 0.2119 0.213
Echinococcus granulosus lamin 0.0027 0.0093 0.0082
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.0327 0.2195 0.2799
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0225 0.1481 0.1471
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.0327 0.2195 0.2799
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.0719 0.0708
Echinococcus granulosus neuropeptide s receptor 0.0516 0.3527 0.3553
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.006 0.0061
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0158 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Echinococcus multilocularis transcription factor btf3 0.0038 0.0165 0.0154
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0158 0.0351
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0022 0.0029
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0022 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0777 0.098
Brugia malayi mbt repeat family protein 0.0047 0.0231 0.0296
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.008 0.0087
Onchocerca volvulus 0.0208 0.1365 0.4121
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0231 0.0221
Schistosoma mansoni ap endonuclease 0.0037 0.016 0.0237
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0223 0.027
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0351
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.0165 0.0196
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0777 0.1227
Echinococcus granulosus GPCR family 2 0.0051 0.0256 0.0246
Treponema pallidum fructose-bisphosphate aldolase 0.0606 0.4155 1
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1856 0.4449
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0096 0.0569
Echinococcus granulosus cytochrome P450 2K1 0.0327 0.2195 0.2206
Trypanosoma cruzi cytochrome P450, putative 0.1126 0.7809 1
Leishmania major cytochrome p450-like protein 0.0327 0.2195 0.2799
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1856 0.4449
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0318 0.14
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0193 0.1257 0.1258
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0298 0.0289
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0231 0.0221
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.0327 0.2195 0.2799
Echinococcus multilocularis tumor protein p63 0.1424 0.9905 1
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0096 0.1834
Echinococcus granulosus peregrin 0.0035 0.0144 0.0133
Mycobacterium tuberculosis Conserved protein 0.0225 0.1481 0.1471
Schistosoma mansoni serine/threonine protein kinase 0.0069 0.0385 0.0598
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 1
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.006 0.0048
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0081 0.0468 0.1909
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0176 0.0166
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.006 0.105
Giardia lamblia Kinase, TTK 0.0088 0.0519 0.1223
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0224 0.0339
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.0327 0.2195 0.2185
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0385 0.0493
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0158 0.0351
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.006 0.0219
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.016 0.0189
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.016 0.0189
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0161
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0606 0.4155 1
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0231 0.0351
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0468 0.0461
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0053 0.0068
Echinococcus granulosus snurportin 1 0.0316 0.2119 0.213
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0145 0.0918 0.0916
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.008 0.0087
Mycobacterium tuberculosis Conserved hypothetical protein 0.0172 0.1108 0.1098
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0054 0.0277 0.0268
Echinococcus granulosus lamin dm0 0.0027 0.0093 0.0082
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.2786 0.3567
Echinococcus multilocularis GPCR, family 2 0.0051 0.0256 0.0246
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0176 0.0396
Mycobacterium ulcerans beta-lactamase 0.0225 0.1481 0.1884
Echinococcus multilocularis neuropeptide receptor A26 0.0516 0.3527 0.3553
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0225 0.1481 0.1897
Brugia malayi Latrophilin receptor protein 2 0.0051 0.0256 0.0328
Loa Loa (eye worm) inositol-1 0.0039 0.0176 0.0226
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0126 0.0519
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0165 0.0369
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.0327 0.2195 0.2185
Entamoeba histolytica hypothetical protein 0.0151 0.0964 0.2221
Toxoplasma gondii NAC domain-containing protein 0.0038 0.0165 0.07
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.0327 0.2195 0.2185
Mycobacterium ulcerans esterase/lipase LipP 0.0225 0.1481 0.1884
Echinococcus multilocularis lamin dm0 0.0027 0.0093 0.0082
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0051 0.0256 0.0246
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.0327 0.2195 0.2799
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0069 0.0385 0.0808
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0081 0.0468 0.31
Trichomonas vaginalis esterase, putative 0.0225 0.1481 0.3546
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.0327 0.2195 0.2185
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0327 0.2195 0.2799
Schistosoma mansoni hypothetical protein 0.0051 0.0256 0.0391
Plasmodium falciparum importin beta, putative 0.003 0.0108 0.2107
Brugia malayi Thioredoxin reductase 0.0046 0.0223 0.0286
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0053 0.0188
Echinococcus granulosus histone acetyltransferase MYST2 0.0054 0.0277 0.0268
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0051 0.0256 0.0246
Mycobacterium tuberculosis Conserved protein 0.0225 0.1481 0.1471
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0147 0.0135
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0053 0.0041
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.0088 0.0519 0.0512
Brugia malayi Smad1 0.0018 0.0029 0.0038
Brugia malayi follicle stimulating hormone receptor 0.0499 0.341 0.4366
Echinococcus multilocularis peregrin 0.0035 0.0144 0.0133
Entamoeba histolytica protein kinase domain containing protein 0.0069 0.0385 0.0808
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0017 0.0022 0.001
Echinococcus granulosus fetal alzheimer antigen falz 0.0027 0.0087 0.0076
Leishmania major cytochrome p450-like protein 0.0327 0.2195 0.2799
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0158 0.0351
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0176 0.021
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0486 0.0761
Schistosoma mansoni transcription factor btf3 0.0038 0.0165 0.0245
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.0327 0.2195 0.2185
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.0088 0.0519 0.0813
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.0327 0.2195 0.2799
Mycobacterium tuberculosis Probable lipase LipD 0.0225 0.1481 0.1471
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0224 0.0214
Brugia malayi Cytochrome P450 family protein 0.0347 0.2338 0.2994
Brugia malayi Importin beta-1 subunit 0.003 0.0108 0.0139
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0351
Echinococcus granulosus zinc finger protein 0.0023 0.0064 0.0052
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.016 0.0205
Schistosoma mansoni hypothetical protein 0.0032 0.0126 0.0182
Entamoeba histolytica hypothetical protein 0.0023 0.006 0.0016
Mycobacterium tuberculosis Probable reductase 0.0105 0.0637 0.0626
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0385 0.0899
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0986 0.1249
Mycobacterium tuberculosis Conserved protein 0.0225 0.1481 0.1471
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0224 0.0287
Loa Loa (eye worm) bromodomain containing protein 0.002 0.0038 0.0049
Onchocerca volvulus 0.0059 0.0318 0.0737
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.0088 0.0519 0.0512
Entamoeba histolytica protein kinase, putative 0.0069 0.0385 0.0808
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0158 0.0351
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0158 0.0187
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0318 0.0309
Trichomonas vaginalis penicillin-binding protein, putative 0.0225 0.1481 0.3546
Leishmania major mitochondrial DNA polymerase beta 0.0326 0.2194 0.2798
Schistosoma mansoni hypothetical protein 0.0327 0.2195 0.3502
Loa Loa (eye worm) beta-lactamase 0.0225 0.1481 0.1897
Loa Loa (eye worm) cytochrome P450 family protein 0.0347 0.2338 0.2994
Brugia malayi CXXC zinc finger family protein 0.0028 0.0097 0.0124
Echinococcus multilocularis mothers against decapentaplegic 5 0.0018 0.0029 0.0017
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.016 0.0189
Schistosoma mansoni thyroid hormone receptor 0.0157 0.1 0.1585
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0327 0.2195 0.2799
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 1
Trypanosoma cruzi hypothetical protein, conserved 0.0225 0.1481 0.1884
Loa Loa (eye worm) AUR protein kinase 0.0069 0.0385 0.0493
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0231 0.0351
Echinococcus granulosus TGF beta signal transducer SmadC 0.0018 0.0029 0.0017
Brugia malayi jmjC domain containing protein 0.0043 0.0199 0.0255
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0327 0.2195 0.2799
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.0327 0.2195 0.2799
Brugia malayi beta-NAC-like protein 0.0038 0.0165 0.0211
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.008 0.046
Brugia malayi serine/threonine-protein kinase 6 0.0069 0.0385 0.0493
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0278 0.1856 0.2376
Trichomonas vaginalis glucosylceramidase, putative 0.0278 0.1856 0.4449
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0272 0.0994
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0637 0.0626
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.4615 0.7386
Brugia malayi MH1 domain containing protein 0.0018 0.0029 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0224 0.0339
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0069 0.0385 0.0377
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.0327 0.2195 0.2185
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0231 0.0457
Schistosoma mansoni hypothetical protein 0.0903 0.6244 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0165 0.1061 0.1358
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0039 0.0176 0.3601
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0004 0.0005
Entamoeba histolytica hypothetical protein 0.0151 0.0964 0.2221
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0318 0.049
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0158 0.0187
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.0719 0.0708
Schistosoma mansoni inositol monophosphatase 0.0039 0.0176 0.0263
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.016 0.3244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 0.1099
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0151 0.0964 0.0962
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.0165 0.3355
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.0777 0.1227
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.0327 0.2195 0.2799
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0606 0.4155 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0051 0.0256 0.0246
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0022 0.0046
Onchocerca volvulus 0.0225 0.1481 0.4497
Trichomonas vaginalis AGC family protein kinase 0.0069 0.0385 0.0899
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.0719 0.3089
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0081 0.0468 0.0584
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.0165 0.0196
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Trichomonas vaginalis glucosylceramidase, putative 0.0183 0.1183 0.2827
Schistosoma mansoni ran 0.0022 0.0053 0.0066
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0108 0.0123
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.016 0.1025 0.1312
Trichomonas vaginalis set domain proteins, putative 0.0467 0.3184 0.7655
Echinococcus granulosus transcription factor btf3 0.0038 0.0165 0.0154
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0223 0.027
Loa Loa (eye worm) hypothetical protein 0.0045 0.0218 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0225 0.1481 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0123 0.0112
Brugia malayi RNA, U transporter 1 0.0084 0.0491 0.0629
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0022 0.001
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.0327 0.2195 0.2185
Schistosoma mansoni myelin transcription factor 1 myt1 0.0054 0.0277 0.0425
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.0777 0.098
Onchocerca volvulus 0.0467 0.3184 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0225 0.1481 0.1485
Loa Loa (eye worm) hypothetical protein 0.0081 0.0468 0.0599
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0069 0.0385 0.2536
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0069 0.0385 0.0377
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0468 0.0461
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.018 0.017
Loa Loa (eye worm) hypothetical protein 0.0049 0.0244 0.0312
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0053 0.0279
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0093 0.012
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.0327 0.2195 0.2799
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0081 0.0468 0.046
Entamoeba histolytica protein kinase, putative 0.0069 0.0385 0.0808
Schistosoma mansoni jumonji/arid domain-containing protein 0.0043 0.0199 0.03
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0126 0.0519
Brugia malayi serine/threonine protein kinase 6 0.0069 0.0385 0.0493
Mycobacterium tuberculosis Probable esterase LipL 0.0225 0.1481 0.1471
Schistosoma mansoni hypothetical protein 0.0017 0.0019 0.0012
Schistosoma mansoni zinc finger protein 0.0017 0.0019 0.0012
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0018 0.0029 0.0028
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.0327 0.2195 0.2185
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0105 0.0638 0.0633
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0126 0.0182
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.009 0.0187
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.006 0.0061
Echinococcus granulosus lysosomal alpha glucosidase 0.0165 0.1061 0.106
Onchocerca volvulus 0.0081 0.0468 0.1224
Brugia malayi cytochrome P450 0.0327 0.2195 0.281

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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