Detailed information for compound 792642

Basic information

Technical information
  • TDR Targets ID: 792642
  • Name: N-(2-carbamoylphenyl)-4-chloro-1-ethylpyrazol e-3-carboxamide
  • MW: 292.721 | Formula: C13H13ClN4O2
  • H donors: 2 H acceptors: 3 LogP: 1.76 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1cc(c(n1)C(=O)Nc1ccccc1C(=O)N)Cl
  • InChi: 1S/C13H13ClN4O2/c1-2-18-7-9(14)11(17-18)13(20)16-10-6-4-3-5-8(10)12(15)19/h3-7H,2H2,1H3,(H2,15,19)(H,16,20)
  • InChiKey: QHNNKLXMCBZVHB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-carbamoylphenyl)-4-chloro-1-ethyl-pyrazole-3-carboxamide
  • N-(2-carbamoylphenyl)-4-chloro-1-ethyl-3-pyrazolecarboxamide
  • N-(2-aminocarbonylphenyl)-4-chloro-1-ethyl-pyrazole-3-carboxamide
  • 1H-Pyrazole-3-carboxylic acid, 4-chloro-1-ethyl-, (2-carbamoylphenyl)amide
  • A3783/0160558
  • MLS000729388
  • N-[2-(aminocarbonyl)phenyl]-4-chloro-1-ethyl-1H-pyrazole-3-carboxamide
  • SMR000307666
  • ZINC01432214

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Cytochrome P450 121 Cyp121 0.003 0.0031 0.0068
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.015 0.4061
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0111 0.0311 0.1254
Mycobacterium ulcerans cytochrome P450 144A4 Cyp144A4 0.003 0.0031 0.02
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0194 0.4746
Plasmodium vivax heterochromatin protein 1, putative 0.0023 0.0006 0.0034
Brugia malayi hypothetical protein 0.0498 0.1638 0.1638
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Mycobacterium ulcerans cytochrome P450 187A5 Cyp187A5 0.003 0.0031 0.02
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0126 0.0126
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0498 0.1638 0.1638
Brugia malayi PAS domain containing protein 0.0101 0.0275 0.0275
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0099 0.2539
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0311
Mycobacterium tuberculosis Probable cytochrome P450 141 Cyp141 0.003 0.0031 0.0068
Schistosoma mansoni cpg binding protein 0.0058 0.0127 0.0127
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0318 0.1021 0.1021
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Brugia malayi Bromodomain containing protein 0.0031 0.0034 0.0034
Mycobacterium tuberculosis Possible cytochrome P450 135A1 Cyp135A1 0.003 0.0031 0.0068
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0127 0.0127
Echinococcus multilocularis transfer RNA-Lys 0.0075 0.0185 0.0185
Onchocerca volvulus 0.0023 0.0006 0.0006
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0026 0.0026
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0026 0.0026
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.003 0.0031 0.0313
Trichomonas vaginalis adenylate cyclase, type VII, putative 0.0026 0.0018 0.0311
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0029 0.0026 0.0526
Loa Loa (eye worm) hypothetical protein 0.004 0.0065 0.0065
Mycobacterium ulcerans cytochrome P450 189A7 Cyp189A7 0.003 0.0031 0.02
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0111 0.0311 0.0311
Schistosoma mansoni chromobox protein 0.0138 0.0403 0.0403
Loa Loa (eye worm) hypothetical protein 0.0029 0.0026 0.0026
Echinococcus multilocularis neuropeptide receptor A26 0.238 0.8103 0.8103
Trichomonas vaginalis adenylate cyclase, putative 0.0026 0.0018 0.0311
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0581 0.0581
Echinococcus multilocularis expressed protein 0.0025 0.0015 0.0015
Echinococcus granulosus chromobox protein 2 0.0023 0.0006 0.0006
Mycobacterium tuberculosis Conserved protein 0.0111 0.0311 0.1254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0581 0.0581
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0099 0.2362
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0094 0.0249 0.0249
Brugia malayi mbt repeat family protein 0.0058 0.0126 0.0126
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0064 0.1468
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0126 0.0126
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0123 0.035 0.035
Brugia malayi beta-lactamase family protein 0.0111 0.0311 0.0311
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0031 0.0408
Echinococcus granulosus sodium and chloride dependent glycine 0.0498 0.1638 0.1638
Mycobacterium ulcerans cytochrome P450 140A5 Cyp140A5 0.003 0.0031 0.02
Echinococcus multilocularis ferritin 0.0025 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0069 0.0166 0.0166
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0028 0.0023 0.0023
Mycobacterium tuberculosis Probable cytochrome P450 monooxygenase 142 Cyp142 0.003 0.0031 0.0068
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0006 0.0006
Plasmodium falciparum transporter, putative 0.0498 0.1638 1
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0153 0.0153
Mycobacterium tuberculosis Possible cytochrome P450 135B1 Cyp135B1 0.003 0.0031 0.0068
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Schistosoma mansoni ferritin 0.0025 0.0015 0.0015
Mycobacterium tuberculosis Probable cytochrome P450 132 Cyp132 0.003 0.0031 0.0068
Echinococcus multilocularis peregrin 0.0031 0.0034 0.0034
Mycobacterium leprae Probable lipase LipE 0.0111 0.0311 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.0063 0.0063
Onchocerca volvulus 0.0498 0.1638 0.1638
Mycobacterium ulcerans cytochrome P450 136A2 Cyp136A2 0.003 0.0031 0.02
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0311 0.7675
Mycobacterium tuberculosis Probable cytochrome P450 138 Cyp138 0.003 0.0031 0.0068
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0063 0.1407
Schistosoma mansoni ap endonuclease 0.004 0.0064 0.0064
Echinococcus granulosus peregrin 0.0031 0.0034 0.0034
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0073 0.068
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0064 0.0064
Schistosoma mansoni ferritin light chain 0.0025 0.0015 0.0015
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0026 0.0159
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0064 0.1433
Loa Loa (eye worm) hypothetical protein 0.0051 0.0102 0.0102
Schistosoma mansoni hypothetical protein 0.0029 0.0026 0.0026
Echinococcus multilocularis Chromobox protein 3 0.0023 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0051 0.1134
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0063 0.1407
Leishmania major DNA polymerase kappa, putative 0.0039 0.0063 0.0561
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0051 0.1134
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0073 0.0073
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.019 0.0581 0.0581
Treponema pallidum sodium- and chloride- dependent transporter 0.2932 1 1
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0019 0.0048
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.0125
Schistosoma mansoni hypothetical protein 0.0101 0.0274 0.0274
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0126 0.0126
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.0039 0.0063 0.0063
Schistosoma mansoni hypothetical protein 0.0217 0.0675 0.0675
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.019 0.0581 0.0581
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0026 0.0018 0.0018
Onchocerca volvulus 0.2932 1 1
Trypanosoma brucei hypothetical protein, conserved 0.0111 0.0311 0.9108
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0065 0.015 0.1644
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0101 0.0274 0.0274
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.0063 0.0063
Echinococcus multilocularis dna polymerase eta 0.0039 0.0063 0.0063
Brugia malayi MH2 domain containing protein 0.0116 0.0328 0.0328
Loa Loa (eye worm) serotonin transporter b 0.2932 1 1
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0018 0.0311
Loa Loa (eye worm) CYP4Cod1 0.003 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.2932 1 1
Echinococcus multilocularis expressed protein 0.0364 0.1178 0.1178
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0064 0.1433
Onchocerca volvulus 0.0111 0.0311 0.0311
Mycobacterium ulcerans cytochrome p450 150 cyp150 0.003 0.0031 0.02
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0498 0.1638 0.1638
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0099 1
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0403 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.012 0.0339 1
Loa Loa (eye worm) hypoxia-induced factor 1 0.0312 0.1001 0.1001
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.0063 0.1726
Mycobacterium tuberculosis Probable cytochrome P450 144 Cyp144 0.003 0.0031 0.0068
Mycobacterium ulcerans lipase LipD 0.0111 0.0311 0.3661
Echinococcus multilocularis serotonin transporter 0.2932 1 1
Echinococcus multilocularis sodium and chloride dependent glycine 0.0498 0.1638 0.1638
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0064 0.0064
Schistosoma mansoni cytochrome P450 0.003 0.0031 0.0031
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0049
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0311 0.9117
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0073 0.0073
Loa Loa (eye worm) hypothetical protein 0.2932 1 1
Schistosoma mansoni sodium-dependent amino acid transporter 0.0498 0.1638 0.1638
Onchocerca volvulus 0.0051 0.0102 0.0102
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0051 0.1134
Trichomonas vaginalis myo inositol monophosphatase, putative 0.012 0.0339 0.8389
Loa Loa (eye worm) beta-lactamase 0.0111 0.0311 0.0311
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0073 0.6347
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.026 0.0822 0.3424
Echinococcus multilocularis inositol monophosphatase 1 0.012 0.0339 0.0339
Schistosoma mansoni zinc finger protein 0.0022 0.0005 0.0005
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.0015 0.0015
Mycobacterium tuberculosis Probable hydrolase 0.0111 0.0311 0.1254
Loa Loa (eye worm) hypothetical protein 0.0078 0.0194 0.0194
Brugia malayi PHD-finger family protein 0.0029 0.0026 0.0026
Toxoplasma gondii hypothetical protein 0.0498 0.1638 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0498 0.1638 0.1638
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0153 0.0153
Loa Loa (eye worm) CHromoDomain protein family member 0.0028 0.0023 0.0023
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0214 0.5254
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0073 0.1703
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0498 0.1638 0.1638
Onchocerca volvulus 0.0061 0.0137 0.0137
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0051 0.1134
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0095 0.0254 0.0254
Mycobacterium tuberculosis Probable cytochrome P450 143 Cyp143 0.003 0.0031 0.0068
Mycobacterium ulcerans cytochrome P450 188A3 Cyp188A3 0.003 0.0031 0.02
Schistosoma mansoni sodium/chloride dependent transporter 0.2932 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0051 0.1134
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0073 0.0073
Mycobacterium ulcerans hypothetical protein 0.0111 0.0311 0.3661
Loa Loa (eye worm) hypothetical protein 0.0465 0.1527 0.1527
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0006 0.0034
Echinococcus granulosus chromobox protein 1 0.0138 0.0403 0.0403
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0064 0.1751
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0064 0.0607
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0063 0.0597
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0111 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.2932 1 1
Mycobacterium tuberculosis Conserved protein 0.0111 0.0311 0.1254
Toxoplasma gondii cytochrome p450 superfamily protein 0.003 0.0031 0.0156
Mycobacterium tuberculosis Probable cytochrome P450 124 Cyp124 0.003 0.0031 0.0068
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0498 0.1638 1
Brugia malayi jmjC domain containing protein 0.004 0.0064 0.0064
Schistosoma mansoni hypothetical protein 0.0358 0.1158 0.1158
Brugia malayi hypoxia-induced factor 1 0.0312 0.1001 0.1001
Toxoplasma gondii hypothetical protein 0.0498 0.1638 1
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0057 0.0057
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0099 0.0575
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0101 0.0274 0.0274
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0101 0.0274 0.0274
Mycobacterium ulcerans cytochrome P450 191A3 Cyp191A3 0.003 0.0031 0.02
Echinococcus granulosus Chromobox protein 3 0.0023 0.0006 0.0006
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0064 0.0064
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0019 0.0048
Loa Loa (eye worm) hypothetical protein 0.0026 0.0018 0.0018
Schistosoma mansoni hypothetical protein 0.0825 0.2761 0.2761
Schistosoma mansoni apoferritin-2 0.0025 0.0015 0.0015
Echinococcus multilocularis GPCR, family 2 0.0101 0.0274 0.0274
Brugia malayi chromobox protein homolog 3 0.0078 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0023 0.0006 0.0034
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0116 0.2789
Loa Loa (eye worm) hypothetical protein 0.0111 0.0311 0.0311
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0094 0.0249 0.0249
Mycobacterium ulcerans cytochrome P450 143A3 Cyp143A3 0.003 0.0031 0.02
Trypanosoma brucei unspecified product 0.0039 0.0063 0.1321
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0006 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0126 0.0126
Schistosoma mansoni single-minded 0.0101 0.0275 0.0275
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0073 0.0073
Echinococcus multilocularis chromobox protein 2 0.0023 0.0006 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0031 0.0031
Schistosoma mansoni sodium/chloride dependent transporter 0.0498 0.1639 0.1639
Brugia malayi CHD4 protein 0.0028 0.0023 0.0023
Schistosoma mansoni cpg binding protein 0.0063 0.0145 0.0145
Echinococcus granulosus chromobox protein 1 0.0138 0.0403 0.0403
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0064 0.5163
Echinococcus granulosus dna polymerase kappa 0.0039 0.0063 0.0063
Loa Loa (eye worm) hypothetical protein 0.0061 0.0137 0.0137
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0498 0.1638 0.1638
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0822 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0581 0.0581
Mycobacterium tuberculosis Cytochrome P450 51 Cyp51 (CYPL1) (P450-L1A1) (sterol 14-alpha demethylase) (lanosterol 14-alpha demethylase) (P450-14DM) 0.003 0.0031 0.0068
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0083 0.0214 0.0214
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0078 0.0194 0.0194
Brugia malayi beta-lactamase 0.0111 0.0311 0.0311
Plasmodium falciparum phd finger protein, putative 0.0029 0.0026 0.0159
Loa Loa (eye worm) hypothetical protein 0.0217 0.0675 0.0675
Echinococcus granulosus neuropeptide receptor A26 0.238 0.8103 0.8103
Loa Loa (eye worm) hypothetical protein 0.0339 0.1091 0.1091
Mycobacterium ulcerans cytochrome P450 143A4 Cyp143A4 0.003 0.0031 0.02
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0063 0.1407
Mycobacterium tuberculosis Probable cytochrome P450 139 Cyp139 0.003 0.0031 0.0068
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Toxoplasma gondii aldehyde dehydrogenase 0.026 0.0822 0.5005
Loa Loa (eye worm) hypothetical protein 0.0042 0.0073 0.0073
Leishmania major protein kinase, putative 0.0027 0.0019 0.0019
Mycobacterium tuberculosis Probable esterase LipL 0.0111 0.0311 0.1254
Loa Loa (eye worm) hypothetical protein 0.0111 0.0311 0.0311
Plasmodium falciparum heterochromatin protein 1 0.0023 0.0006 0.0034
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0101 0.0274 0.0274
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0065 0.015 0.015
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0131 0.0131
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.0015 0.0015
Schistosoma mansoni hypothetical protein 0.0095 0.0254 0.0254
Brugia malayi beta-lactamase family protein 0.0111 0.0311 0.0311
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0063 0.0063
Loa Loa (eye worm) cytochrome P450 family protein 0.0067 0.0159 0.0159
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0498 0.1638 0.1638
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0073 0.1703
Leishmania major cytochrome p450-like protein 0.003 0.0031 0.0163
Schistosoma mansoni ap endonuclease 0.004 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Plasmodium vivax amine transporter, putative 0.0498 0.1638 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.003 0.003 0.0609
Schistosoma mansoni inositol monophosphatase 0.012 0.0339 0.0339
Echinococcus granulosus aryl hydrocarbon receptor 0.0026 0.0018 0.0018
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.0015 0.0015
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.0063 0.1407
Mycobacterium ulcerans cytochrome P450 123A3 Cyp123A3 0.003 0.0031 0.02
Schistosoma mansoni chromobox protein 0.0023 0.0006 0.0006
Trichomonas vaginalis chromobox protein, putative 0.0138 0.0403 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0111 0.0311 0.3661
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0023 0.0006 0.0034
Brugia malayi PHD-finger family protein 0.0028 0.0023 0.0023
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0063 0.1321
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0073 0.0073
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0026 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0111 0.0311 0.0311
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0099 0.0099
Mycobacterium tuberculosis Probable cytochrome P450 137 Cyp137 0.003 0.0031 0.0068
Echinococcus multilocularis chromobox protein 1 0.0138 0.0403 0.0403
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.012 0.0339 1
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0031 0.0408
Echinococcus granulosus dna polymerase eta 0.0039 0.0063 0.0063
Leishmania major protein kinase, putative 0.0027 0.0019 0.0019
Brugia malayi Associated with TFs and helicases family protein 0.0023 0.0006 0.0006
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0064 0.0064
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Trichomonas vaginalis inositol monophosphatase, putative 0.012 0.0339 0.8389
Loa Loa (eye worm) helicase 0.0023 0.0006 0.0006
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0064 0.0064
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.019 0.0581 0.0581
Toxoplasma gondii histone lysine methyltransferase SET1 0.0112 0.0313 0.1882
Echinococcus granulosus sodium and chloride dependent glycine 0.0498 0.1638 0.1638
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0049
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0073 0.1621
Schistosoma mansoni ferritin light chain 0.0025 0.0015 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0311
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0311 0.0311
Brugia malayi hypothetical protein 0.0465 0.1527 0.1527
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0018 0.0311
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.012 0.0339 0.399
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0318 0.1021 0.1021
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0051 0.1134
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0099 0.2362
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.015 0.4119
Leishmania major cytochrome p450-like protein 0.003 0.0031 0.0163
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0018 0.0311
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0498 0.1638 0.1638
Mycobacterium tuberculosis Probable lipase LipE 0.0111 0.0311 0.1254
Loa Loa (eye worm) hypothetical protein 0.0318 0.1021 0.1021
Echinococcus granulosus jumonji domain containing protein 0.004 0.0064 0.0064
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0099 0.2465
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0036 0.0051 0.1134
Schistosoma mansoni survival motor neuron protein 0.0095 0.0254 0.0254
Echinococcus multilocularis chromobox protein 1 0.0138 0.0403 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.0063 0.1447
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0064 0.1513
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0063 0.1321
Plasmodium falciparum amino acid transporter, putative 0.0498 0.1638 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0822 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0028 0.0023 0.0023
Schistosoma mansoni inositol monophosphatase 0.012 0.0339 0.0339
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.0027 0.0027
Mycobacterium tuberculosis Probable cytochrome P450 123 Cyp123 0.003 0.0031 0.0068
Trichomonas vaginalis esterase, putative 0.0111 0.0311 0.7675
Toxoplasma gondii ABC1 family protein 0.0111 0.0311 0.1869
Loa Loa (eye worm) solute carrier family 6 member 4 0.2932 1 1
Loa Loa (eye worm) cytochrome P450 0.003 0.0031 0.0031
Trypanosoma cruzi cytochrome p450-like protein, putative 0.003 0.0031 0.0408
Echinococcus granulosus expressed protein 0.0364 0.1178 0.1178
Trypanosoma cruzi DNA polymerase eta, putative 0.0039 0.0063 0.1407
Schistosoma mansoni cpg binding protein 0.0063 0.0145 0.0145
Echinococcus granulosus cpg binding protein 0.0063 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0065 0.015 0.015
Onchocerca volvulus 0.0498 0.1638 0.1638
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0311 0.7675
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0498 0.1638 0.1638
Echinococcus multilocularis neuropeptide s receptor 0.238 0.8103 0.8103
Plasmodium vivax hypothetical protein, conserved 0.0111 0.0311 0.1897
Schistosoma mansoni hypothetical protein 0.0101 0.0274 0.0274
Echinococcus multilocularis sodium and chloride dependent glycine 0.0498 0.1638 0.1638
Mycobacterium ulcerans cytochrome P450 51B1 Cyp51B1 0.003 0.0031 0.02
Schistosoma mansoni hypothetical protein 0.0101 0.0274 0.0274
Leishmania major lanosterol 14-alpha-demethylase, putative 0.003 0.0031 0.0163
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0028 0.0023 0.0023
Mycobacterium ulcerans beta-lactamase 0.0111 0.0311 0.3661
Schistosoma mansoni sodium/chloride dependent transporter 0.0498 0.1638 0.1638
Leishmania major DNA polymerase eta, putative 0.0039 0.0063 0.0561
Brugia malayi Latrophilin receptor protein 2 0.0101 0.0274 0.0274
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.026 0.0822 0.0822
Schistosoma mansoni ferritin 0.0025 0.0015 0.0015
Loa Loa (eye worm) hypothetical protein 0.0038 0.0057 0.0057
Mycobacterium ulcerans cytochrome P450 150A6 Cyp150A6 0.003 0.0031 0.02
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0111 0.0311 0.0311
Schistosoma mansoni lipoxygenase 0.0088 0.023 0.023
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0498 0.1638 0.1638
Echinococcus multilocularis aryl hydrocarbon receptor 0.0026 0.0018 0.0018
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0153 0.0153
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0018 0.0311
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0153 0.0153
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0073 0.1687
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0126 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.0063 0.0063
Mycobacterium leprae putative cytochrome p450 0.003 0.0031 0.0545
Trichomonas vaginalis D-aminoacylase, putative 0.0111 0.0311 0.7675
Mycobacterium ulcerans cytochrome P450 105Q4 Cyp105Q4 0.003 0.0031 0.02
Brugia malayi M-phase phosphoprotein, mpp8 0.0023 0.0006 0.0006
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0111 0.0311 0.1254
Trichomonas vaginalis adenylate and guanylate cyclases, putative 0.0026 0.0018 0.0311
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.019 0.0581 0.0581
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Brugia malayi Heterochromatin protein 1 0.0138 0.0403 0.0403
Mycobacterium ulcerans cytochrome P450 124A1, Cyp124A1 0.003 0.0031 0.02
Mycobacterium leprae conserved hypothetical protein 0.0111 0.0311 1
Echinococcus multilocularis survival motor neuron protein 1 0.0465 0.1527 0.1527
Trypanosoma brucei cytochrome P450, putative 0.003 0.0031 0.0313
Trichomonas vaginalis conserved hypothetical protein 0.0078 0.0194 0.4746
Mycobacterium ulcerans cytochrome P450 142A3 Cyp142A3 0.003 0.0031 0.02
Mycobacterium ulcerans esterase/lipase LipP 0.0111 0.0311 0.3661
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.0063 0.0063
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0099 0.2539
Brugia malayi Bromodomain containing protein 0.0038 0.0057 0.0057
Echinococcus multilocularis cpg binding protein 0.0063 0.0145 0.0145
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0107 0.0296 0.1191
Schistosoma mansoni chromobox protein 0.0138 0.0403 0.0403
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0064 0.1347
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0099 0.0099
Brugia malayi Cytochrome P450 family protein 0.0067 0.0159 0.0159
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0111 0.0311 0.1254
Loa Loa (eye worm) latrophilin receptor protein 2 0.0101 0.0274 0.0274
Mycobacterium ulcerans putative regulatory protein 0.0075 0.0185 0.21
Leishmania major cytochrome p450-like protein 0.003 0.0031 0.0163
Echinococcus multilocularis dnaJ subfamily B 0.0825 0.2761 0.2761
Onchocerca volvulus 0.0111 0.0311 0.0311
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0153 0.0153
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Echinococcus granulosus Chromo domain 0.0023 0.0006 0.0006
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0064 0.0064
Brugia malayi mbt repeat family protein 0.0058 0.0126 0.0126
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0065 0.015 0.015
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0026 0.0125
Brugia malayi latrophilin 2 splice variant baaae 0.0217 0.0675 0.0675
Mycobacterium tuberculosis Probable cytochrome P450 140 Cyp140 0.003 0.0031 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0311 0.7675
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0064 0.0064
Brugia malayi Inositol-1 0.012 0.0339 0.0339
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0126 0.0126
Echinococcus granulosus tumor protein p63 0.0347 0.112 0.112
Loa Loa (eye worm) hypothetical protein 0.0111 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0101 0.0274 0.0274
Mycobacterium tuberculosis Probable lipase LipD 0.0111 0.0311 0.1254
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0498 0.1638 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0101 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0064 0.039
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0235 0.0735 0.0735
Mycobacterium leprae Possible regulatory protein 0.0026 0.0018 0.0102
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0064 0.039
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0065 0.015 0.015
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0498 0.1638 0.1638
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.0063 0.0204
Schistosoma mansoni cellular tumor antigen P53 0.0051 0.0102 0.0102
Echinococcus multilocularis microtubule associated protein 2 0.0733 0.2445 0.2445
Brugia malayi Cytochrome P450 family protein 0.003 0.0031 0.0031
Loa Loa (eye worm) norepinephrine transporter 0.2932 1 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0024 0.001 0.001
Brugia malayi MAP kinase sur-1 0.005 0.0099 0.0099
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0073 0.2011
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.0063 0.1321
Toxoplasma gondii exonuclease III APE 0.004 0.0064 0.0358
Loa Loa (eye worm) hypothetical protein 0.0049 0.0096 0.0096
Brugia malayi CXXC zinc finger family protein 0.0058 0.0127 0.0127
Echinococcus granulosus cytochrome P450 2K1 0.003 0.0031 0.0031
Schistosoma mansoni ferritin 0.0025 0.0015 0.0015
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0073 0.0073
Brugia malayi follicle stimulating hormone receptor 0.0519 0.171 0.171
Brugia malayi jmjC domain containing protein 0.0094 0.0249 0.0249
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0126 0.0126
Brugia malayi Cytochrome P450 family protein 0.003 0.0031 0.0031
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0099 0.0099
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0027 0.0019 0.0048
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.0063 0.0561
Mycobacterium tuberculosis Probable cytochrome P450 130 Cyp130 0.003 0.0031 0.0068
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0023 0.0006 0.0006
Brugia malayi hypothetical protein 0.0339 0.1091 0.1091
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.014 0.014
Schistosoma mansoni lipoxygenase 0.0126 0.036 0.036
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0101 0.0274 0.0274
Echinococcus granulosus microtubule associated protein 2 0.0733 0.2445 0.2445
Loa Loa (eye worm) cytochrome P450 family protein 0.003 0.0031 0.0031
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.012 0.0339 1
Loa Loa (eye worm) hypothetical protein 0.0111 0.0311 0.0311
Brugia malayi Cytochrome P450 family protein 0.003 0.0031 0.0031
Echinococcus granulosus zinc finger protein 0.0022 0.0005 0.0005
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0099 0.2539
Trypanosoma cruzi hypothetical protein, conserved 0.0111 0.0311 0.9117
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.0063 0.0204
Mycobacterium tuberculosis Possible cytochrome P450 126 Cyp126 0.003 0.0031 0.0068
Echinococcus granulosus inositol monophosphatase 1 0.012 0.0339 0.0339
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0073 0.0073
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0126 0.0126
Leishmania major hypothetical protein, conserved 0.0111 0.0311 0.3638
Echinococcus multilocularis Chromo domain 0.0023 0.0006 0.0006
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0073 0.1687
Trypanosoma brucei protein kinase, putative 0.005 0.0099 0.2465
Echinococcus granulosus beta LACTamase domain containing family member 0.0111 0.0311 0.0311
Trichomonas vaginalis conserved hypothetical protein 0.003 0.003 0.0609
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0498 0.1638 0.1638
Echinococcus granulosus expressed protein 0.0025 0.0015 0.0015
Brugia malayi hypothetical protein 0.0023 0.0006 0.0006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.012 0.0339 0.4012
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0126 0.036 0.036
Schistosoma mansoni ferritin 0.0025 0.0015 0.0015
Echinococcus multilocularis 0.003 0.0031 0.0031
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.0063 0.0597
Schistosoma mansoni DNA polymerase eta 0.0039 0.0063 0.0063
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.026 0.0822 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0099 0.2362
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.0063 0.0063
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0498 0.1638 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Onchocerca volvulus Alhambra homolog 0.0029 0.0026 0.0026
Schistosoma mansoni bromodomain containing protein 0.0065 0.0152 0.0152
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0099 0.2362
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0498 0.1638 0.1638
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0107 0.0296 0.9502
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0099 0.0099
Loa Loa (eye worm) inositol-1 0.012 0.0339 0.0339
Echinococcus granulosus survival motor neuron protein 1 0.0465 0.1527 0.1527
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0064 0.0049
Loa Loa (eye worm) hypothetical protein 0.0498 0.1638 0.1638
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Loa Loa (eye worm) heterochromatin protein 1 0.0138 0.0403 0.0403
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0116 0.2789
Mycobacterium ulcerans cytochrome P450 126A3 Cyp126A3 0.003 0.0031 0.02
Mycobacterium tuberculosis Probable cytochrome P450 128 Cyp128 0.003 0.0031 0.0068
Onchocerca volvulus 0.0075 0.0185 0.0185
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.026 0.0822 0.0822
Mycobacterium leprae Conserved hypothetical protein 0.003 0.0031 0.0545
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0065 0.015 0.4338
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0822 0.0822
Trypanosoma brucei DNA polymerase eta, putative 0.0039 0.0063 0.1321
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0057 0.0057
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0581 0.0581
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0235 0.0735 0.0735
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0064 0.0064
Onchocerca volvulus 0.0095 0.0254 0.0254
Echinococcus granulosus dnaJ subfamily B 0.0825 0.2761 0.2761
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0065 0.015 0.4119
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0064 0.0572
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0064 0.1468
Mycobacterium ulcerans cytochrome P450 108B4 Cyp108B4 0.003 0.0031 0.02
Brugia malayi bHLH-PAS transcription factor 0.0075 0.0185 0.0185
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.003 0.0031 0.0408
Brugia malayi Calcitonin receptor-like protein seb-1 0.0318 0.1021 0.1021
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0099 0.1013
Trichomonas vaginalis chromobox protein, putative 0.0083 0.0214 0.5254
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.019 0.0581 0.0581
Schistosoma mansoni hypothetical protein 0.0101 0.0274 0.0274
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0023 0.0006 0.0006
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0036 0.0051 0.1134
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.2932 1 1
Giardia lamblia DINP protein human, muc B family 0.0039 0.0063 0.5049
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0065 0.015 0.015
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.012 0.0339 1
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0027 0.0019 0.0048
Trichomonas vaginalis guanylate cyclase, putative 0.0026 0.0018 0.0311
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 0.003 0.0031 0.0068
Trichomonas vaginalis penicillin-binding protein, putative 0.0111 0.0311 0.7675
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.014 0.014
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0026 0.0018 0.0018
Echinococcus granulosus GPCR family 2 0.0101 0.0274 0.0274
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.0063 0.1321
Echinococcus granulosus neuropeptide s receptor 0.238 0.8103 0.8103
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.012 0.0339 0.2043
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0498 0.1638 1
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0026 0.0026
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0023 0.0006 0.0006
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.0063 0.0063
Echinococcus granulosus serotonin transporter 0.2932 1 1
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0099 0.0099
Schistosoma mansoni hypothetical protein 0.003 0.0031 0.0031
Brugia malayi cytochrome P450 0.003 0.0031 0.0031
Onchocerca volvulus 0.0498 0.1638 0.1638
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Entamoeba histolytica myo-inositol monophosphatase, putative 0.012 0.0339 1
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0183 0.0183
Onchocerca volvulus 0.0111 0.0311 0.0311
Schistosoma mansoni hypothetical protein 0.0023 0.0006 0.0006
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0519 0.171 0.171
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0064 0.0064
Brugia malayi SET domain containing protein 0.0024 0.001 0.001
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0023 0.0006 0.0006
Mycobacterium ulcerans aldehyde dehydrogenase 0.026 0.0822 1
Trichomonas vaginalis soluble guanylate cyclase gcy, putative 0.0026 0.0018 0.0311
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0064 0.0208
Onchocerca volvulus 0.0058 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0023 0.0006 0.0006
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0328 0.0328
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0073 0.0073
Echinococcus multilocularis dna polymerase kappa 0.0039 0.0063 0.0063
Mycobacterium tuberculosis Probable cytochrome P450 125 Cyp125 0.003 0.0031 0.0068
Echinococcus multilocularis beta LACTamase domain containing family member 0.0111 0.0311 0.0311
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0153 0.0153
Echinococcus multilocularis zinc finger protein 0.0022 0.0005 0.0005
Onchocerca volvulus 0.0023 0.0006 0.0006
Schistosoma mansoni aldehyde dehydrogenase 0.026 0.0822 0.0822
Plasmodium vivax hypothetical protein, conserved 0.0498 0.1638 1
Brugia malayi Valyl-tRNA synthetase 0.0023 0.0006 0.0006
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0023 0.0006 0.0006
Trichomonas vaginalis ferritin, putative 0.0025 0.0015 0.0235
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0328 0.0328
Echinococcus granulosus ferritin 0.0025 0.0015 0.0015
Brugia malayi Bromodomain containing protein 0.0077 0.0192 0.0192
Loa Loa (eye worm) hypothetical protein 0.0045 0.0083 0.0083
Mycobacterium ulcerans cytochrome P450 187A4 Cyp187A4 0.003 0.0031 0.02
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0498 0.1638 0.1638
Brugia malayi Protein cec-1. 0.0023 0.0006 0.0006
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0009 0.0009
Schistosoma mansoni microtubule-associated protein tau 0.0733 0.2445 0.2445
Loa Loa (eye worm) hypothetical protein 0.0111 0.0311 0.0311
Loa Loa (eye worm) hypothetical protein 0.0066 0.0153 0.0153
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0099 0.0099
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.0063 0.1447
Echinococcus granulosus single minded 2 0.0075 0.0185 0.0185
Trypanosoma cruzi cytochrome P450, putative 0.003 0.0031 0.0408
Schistosoma mansoni apoferritin-2 0.0025 0.0015 0.0015
Loa Loa (eye worm) MBCTL1 0.0066 0.0153 0.0153
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0126 0.036 0.036
Echinococcus multilocularis tumor protein p63 0.0347 0.112 0.112
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0498 0.1638 0.1638
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0099 0.2539
Schistosoma mansoni chromobox protein 0.0023 0.0006 0.0006
Mycobacterium ulcerans cytochrome P450 125A7 Cyp125A7 0.003 0.0031 0.02
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.003 0.0031 0.02
Trichomonas vaginalis myo inositol monophosphatase, putative 0.012 0.0339 0.8389
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0111 0.0311 0.1254
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0712 0.2373 1
Onchocerca volvulus 0.0024 0.001 0.001
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0126 0.0126
Loa Loa (eye worm) hypothetical protein 0.0058 0.0126 0.0126
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0047 0.0047
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0026 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0073 0.1687
Onchocerca volvulus 0.0058 0.0127 0.0127
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0099 0.1013
Onchocerca volvulus 0.0026 0.0018 0.0018

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.1 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 20.5878 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 50.1187 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] ChEMBL. No reference
Potency (functional) 79.4328 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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